ID 6A2LA STANDARD; PRT; 608 AA. DT CONVERTED FROM PDB (SEQRES) 6A2L DE Bifunctional dihydrofolate reductase-thymidylate synthase OS Plasmodium falciparum CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.380 CC R-Factor 0.200 FT #SUB 10 10 ASP A 285 285 GLU B Protein S 1 FT #SUB 12 12 TYR A 285 285 GLU B Protein S 5 FT #SUB 53 53 LEU A 295 295 PHE B Protein A 4 FT #SUB 53 53 LEU A 296 296 ASN B Protein S 3 FT #SUB 56 56 LYS A 295 295 PHE B Protein S 1 FT #SUB 56 56 LYS A 296 296 ASN B Protein S 3 FT #SUB 57 57 TYR A 292 292 TYR B Protein S 2 FT #SUB 57 57 TYR A 293 293 PHE B Protein S 1 FT #SUB 57 57 TYR A 295 295 PHE B Protein A 10 FT #SUB 60 60 ALA A 295 295 PHE B Protein S 1 FT #SUB 61 61 VAL A 292 292 TYR B Protein S 3 FT #SUB 64 64 TYR A 288 288 ASP B Protein S 2 FT #SUB 64 64 TYR A 291 291 VAL B Protein S 2 FT #SUB 64 64 TYR A 292 292 TYR B Protein S 1 FT #SUB 69 69 LYS A 284 284 ASP B Protein S 6 FT #SUB 69 69 LYS A 287 287 GLU B Protein S 2 FT #SUB 69 69 LYS A 288 288 ASP B Protein S 4 FT #SUB 72 72 LYS A 284 284 ASP B Protein S 3 FT #SUB 159 159 TYR A 288 288 ASP B Protein S 5 FT #SUB 160 160 LYS A 288 288 ASP B Protein S 4 FT #SUB 160 160 LYS A 292 292 TYR B Protein S 2 FT #SUB 180 180 LYS A 285 285 GLU B Protein S 6 FT #SUB 181 181 LYS A 285 285 GLU B Protein S 1 FT #SUB 181 181 LYS A 286 286 GLU B Protein S 4 FT #SUB 181 181 LYS A 289 289 ASP B Protein S 4 FT #SUB 183 183 TYR A 289 289 ASP B Protein S 5 FT #SUB 183 183 TYR A 292 292 TYR B Protein S 6 FT #SUB 209 209 SER A 293 293 PHE B Protein S 2 FT #SUB 210 210 VAL A 293 293 PHE B Protein B 2 FT #SUB 211 211 SER A 293 293 PHE B Protein A 3 FT #SUB 214 214 TYR A 295 295 PHE B Protein S 1 FT #SUB 223 223 PHE A 293 293 PHE B Protein B 2 FT #SUB 223 223 PHE A 295 295 PHE B Protein S 3 FT #SUB 225 225 ILE A 289 289 ASP B Protein S 5 FT #SUB 225 225 ILE A 293 293 PHE B Protein S 2 FT #SUB 227 227 LYS A 286 286 GLU B Protein S 5 FT #SUB 284 284 ASP A 69 69 LYS B Protein B 2 FT #SUB 284 284 ASP A 72 72 LYS B Protein S 1 FT #SUB 285 285 GLU A 181 181 LYS B Protein A 4 FT #SUB 286 286 GLU A 181 181 LYS B Protein S 2 FT #SUB 286 286 GLU A 208 208 ILE B Protein S 1 FT #SUB 286 286 GLU A 227 227 LYS B Protein S 1 FT #SUB 286 286 GLU A 320 320 TYR B Protein B 2 FT #SUB 288 288 ASP A 64 64 TYR B Protein S 2 FT #SUB 288 288 ASP A 69 69 LYS B Protein S 3 FT #SUB 288 288 ASP A 159 159 TYR B Protein S 5 FT #SUB 288 288 ASP A 160 160 LYS B Protein S 2 FT #SUB 289 289 ASP A 181 181 LYS B Protein S 4 FT #SUB 289 289 ASP A 183 183 TYR B Protein S 5 FT #SUB 289 289 ASP A 225 225 ILE B Protein S 4 FT #SUB 290 290 PHE A 320 320 TYR B Protein A 3 FT #SUB 290 290 PHE A 322 322 TYR B Protein S 2 FT #SUB 291 291 VAL A 64 64 TYR B Protein S 1 FT #SUB 292 292 TYR A 57 57 TYR B Protein B 1 FT #SUB 292 292 TYR A 61 61 VAL B Protein S 7 FT #SUB 292 292 TYR A 183 183 TYR B Protein S 4 FT #SUB 293 293 PHE A 57 57 TYR B Protein S 1 FT #SUB 293 293 PHE A 209 209 SER B Protein S 2 FT #SUB 293 293 PHE A 210 210 VAL B Protein S 2 FT #SUB 293 293 PHE A 211 211 SER B Protein S 1 FT #SUB 293 293 PHE A 223 223 PHE B Protein S 3 FT #SUB 293 293 PHE A 225 225 ILE B Protein S 2 FT #SUB 293 293 PHE A 322 322 TYR B Protein S 2 FT #SUB 295 295 PHE A 53 53 LEU B Protein S 6 FT #SUB 295 295 PHE A 56 56 LYS B Protein B 2 FT #SUB 295 295 PHE A 57 57 TYR B Protein S 9 FT #SUB 295 295 PHE A 223 223 PHE B Protein S 3 FT #SUB 296 296 ASN A 53 53 LEU B Protein S 3 FT #SUB 296 296 ASN A 56 56 LYS B Protein S 3 FT #SUB 320 320 TYR A 286 286 GLU B Protein S 4 FT #SUB 320 320 TYR A 290 290 PHE B Protein S 2 FT #SUB 320 320 TYR A 293 293 PHE B Protein S 1 FT #SUB 322 322 TYR A 290 290 PHE B Protein S 2 FT #SUB 322 322 TYR A 293 293 PHE B Protein S 3 FT #SUB 340 340 ASN A 497 497 TYR B Protein S 5 FT #SUB 340 340 ASN A 499 499 PHE B Protein S 13 FT #SUB 341 341 LYS A 499 499 PHE B Protein B 2 FT #SUB 342 342 GLN A 497 497 TYR B Protein S 3 FT #SUB 342 342 GLN A 498 498 VAL B Protein S 3 FT #SUB 342 342 GLN A 499 499 PHE B Protein S 2 FT #SUB 343 343 SER A 468 468 THR B Protein A 5 FT #SUB 344 344 ASP A 470 470 ARG B Protein S 5 FT #SUB 345 345 ARG A 471 471 ARG B Protein S 2 FT #SUB 352 352 SER A 497 497 TYR B Protein A 6 FT #SUB 354 354 PHE A 359 359 LYS B Protein B 1 FT #SUB 354 354 PHE A 495 495 GLN B Protein S 5 FT #SUB 354 354 PHE A 496 496 PHE B Protein S 2 FT #SUB 354 354 PHE A 497 497 TYR B Protein S 14 FT #SUB 354 354 PHE A 504 504 SER B Protein S 3 FT #SUB 354 354 PHE A 505 505 CYS B Protein S 2 FT #SUB 354 354 PHE A 506 506 ILE B Protein S 7 FT #SUB 354 354 PHE A 544 544 ILE B Protein A 2 FT #SUB 355 355 GLY A 359 359 LYS B Protein B 3 FT #SUB 355 355 GLY A 506 506 ILE B Protein B 1 FT #SUB 357 357 ILE A 357 357 ILE B Protein S 1 FT #SUB 359 359 LYS A 354 354 PHE B Protein S 1 FT #SUB 359 359 LYS A 355 355 GLY B Protein S 3 FT #SUB 416 416 ARG A 471 471 ARG B Protein S 1 FT #SUB 437 437 PHE A 478 478 ASN B Protein S 2 FT #SUB 437 437 PHE A 479 479 VAL B Protein S 11 FT #SUB 437 437 PHE A 480 480 LYS B Protein S 2 FT #SUB 438 438 GLY A 480 480 LYS B Protein B 1 FT #SUB 453 453 VAL A 479 479 VAL B Protein S 2 FT #SUB 455 455 GLN A 479 479 VAL B Protein S 4 FT #SUB 468 468 THR A 343 343 SER B Protein S 4 FT #SUB 470 470 ARG A 344 344 ASP B Protein S 5 FT #SUB 470 470 ARG A 510 510 ARG B Protein A 7 FT #SUB 470 470 ARG A 511 511 SER B Protein S 2 FT #SUB 470 470 ARG A 549 549 ASN B Protein S 5 FT #SUB 470 470 ARG A 551 551 HIS B Protein S 9 FT #SUB 470 470 ARG A 553 553 TYR B Protein S 3 FT #SUB 471 471 ARG A 345 345 ARG B Protein S 3 FT #SUB 471 471 ARG A 416 416 ARG B Protein S 1 FT #SUB 471 471 ARG A 488 488 PRO B Protein S 3 FT #SUB 471 471 ARG A 510 510 ARG B Protein S 1 FT #SUB 473 473 LEU A 477 477 TRP B Protein S 2 FT #SUB 473 473 LEU A 492 492 ILE B Protein S 2 FT #SUB 473 473 LEU A 510 510 ARG B Protein S 2 FT #SUB 475 475 CYS A 477 477 TRP B Protein S 2 FT #SUB 475 475 CYS A 479 479 VAL B Protein S 1 FT #SUB 477 477 TRP A 473 473 LEU B Protein S 1 FT #SUB 477 477 TRP A 475 475 CYS B Protein S 1 FT #SUB 478 478 ASN A 437 437 PHE B Protein S 1 FT #SUB 479 479 VAL A 437 437 PHE B Protein A 12 FT #SUB 479 479 VAL A 453 453 VAL B Protein S 2 FT #SUB 479 479 VAL A 455 455 GLN B Protein S 4 FT #SUB 480 480 LYS A 437 437 PHE B Protein B 2 FT #SUB 480 480 LYS A 438 438 GLY B Protein S 1 FT #SUB 488 488 PRO A 471 471 ARG B Protein S 8 FT #SUB 492 492 ILE A 473 473 LEU B Protein S 1 FT #SUB 492 492 ILE A 493 493 LEU B Protein S 1 FT #SUB 493 493 LEU A 492 492 ILE B Protein S 1 FT #SUB 493 493 LEU A 493 493 LEU B Protein S 1 FT #SUB 495 495 GLN A 354 354 PHE B Protein A 4 FT #SUB 495 495 GLN A 508 508 TYR B Protein S 5 FT #SUB 495 495 GLN A 510 510 ARG B Protein S 10 FT #SUB 495 495 GLN A 548 548 GLY B Protein S 1 FT #SUB 496 496 PHE A 354 354 PHE B Protein B 2 FT #SUB 497 497 TYR A 340 340 ASN B Protein S 5 FT #SUB 497 497 TYR A 342 342 GLN B Protein S 4 FT #SUB 497 497 TYR A 352 352 SER B Protein S 6 FT #SUB 497 497 TYR A 354 354 PHE B Protein S 14 FT #SUB 497 497 TYR A 549 549 ASN B Protein S 2 FT #SUB 498 498 VAL A 342 342 GLN B Protein B 2 FT #SUB 499 499 PHE A 340 340 ASN B Protein S 14 FT #SUB 499 499 PHE A 341 341 LYS B Protein S 1 FT #SUB 499 499 PHE A 342 342 GLN B Protein A 3 FT #SUB 504 504 SER A 354 354 PHE B Protein S 1 FT #SUB 505 505 CYS A 354 354 PHE B Protein B 1 FT #SUB 506 506 ILE A 354 354 PHE B Protein A 7 FT #SUB 506 506 ILE A 355 355 GLY B Protein S 2 FT #SUB 506 506 ILE A 508 508 TYR B Protein S 4 FT #SUB 506 506 ILE A 548 548 GLY B Protein S 1 FT #SUB 508 508 TYR A 495 495 GLN B Protein S 5 FT #SUB 508 508 TYR A 506 506 ILE B Protein S 4 FT #SUB 510 510 ARG A 470 470 ARG B Protein S 6 FT #SUB 510 510 ARG A 471 471 ARG B Protein S 2 FT #SUB 510 510 ARG A 473 473 LEU B Protein S 2 FT #SUB 510 510 ARG A 495 495 GLN B Protein A 11 FT #SUB 511 511 SER A 470 470 ARG B Protein S 3 FT #SUB 544 544 ILE A 354 354 PHE B Protein S 2 FT #SUB 546 546 VAL A 546 546 VAL B Protein S 1 FT #SUB 548 548 GLY A 495 495 GLN B Protein B 1 FT #SUB 548 548 GLY A 506 506 ILE B Protein B 1 FT #SUB 549 549 ASN A 470 470 ARG B Protein S 4 FT #SUB 549 549 ASN A 497 497 TYR B Protein S 2 FT #SUB 551 551 HIS A 470 470 ARG B Protein S 8 FT #SUB 553 553 TYR A 470 470 ARG B Protein S 3 FT #HET 14 14 ILE A 1 701 9QO A A 8 FT #HET 15 15 CYS A 1 701 9QO A B 11 FT #HET 15 15 CYS A 2 702 NAP A A 3 FT #HET 16 16 ALA A 1 701 9QO A A 6 FT #HET 16 16 ALA A 2 702 NAP A A 10 FT #HET 40 40 LEU A 2 702 NAP A A 11 FT #HET 41 41 GLY A 2 702 NAP A B 2 FT #HET 42 42 ASN A 2 702 NAP A B 1 FT #HET 44 44 GLY A 2 702 NAP A B 6 FT #HET 45 45 VAL A 2 702 NAP A B 7 FT #HET 46 46 LEU A 1 701 9QO A S 2 FT #HET 46 46 LEU A 2 702 NAP A A 4 FT #HET 48 48 TRP A 2 702 NAP A S 1 FT #HET 54 54 ASP A 1 701 9QO A S 12 FT #HET 55 55 MET A 1 701 9QO A S 6 FT #HET 58 58 PHE A 1 701 9QO A S 13 FT #HET 105 105 GLY A 2 702 NAP A B 7 FT #HET 106 106 ARG A 2 702 NAP A A 18 FT #HET 107 107 THR A 2 702 NAP A A 13 FT #HET 108 108 ASN A 1 701 9QO A S 1 FT #HET 108 108 ASN A 2 702 NAP A A 9 FT #HET 111 111 SER A 1 701 9QO A B 2 FT #HET 111 111 SER A 2 702 NAP A S 1 FT #HET 112 112 ILE A 1 701 9QO A S 1 FT #HET 113 113 PRO A 1 701 9QO A S 2 FT #HET 116 116 PHE A 1 701 9QO A S 21 FT #HET 119 119 LEU A 1 701 9QO A S 2 FT #HET 127 127 LEU A 2 702 NAP A A 11 FT #HET 128 128 SER A 2 702 NAP A A 10 FT #HET 129 129 ARG A 2 702 NAP A A 11 FT #HET 130 130 THR A 2 702 NAP A A 8 FT #HET 144 144 ASN A 2 702 NAP A B 4 FT #HET 146 146 VAL A 2 702 NAP A A 2 FT #HET 164 164 LEU A 1 701 9QO A B 3 FT #HET 164 164 LEU A 2 702 NAP A B 2 FT #HET 165 165 GLY A 2 702 NAP A B 2 FT #HET 166 166 GLY A 2 702 NAP A B 11 FT #HET 167 167 SER A 2 702 NAP A A 7 FT #HET 168 168 VAL A 2 702 NAP A A 11 FT #HET 169 169 VAL A 2 702 NAP A A 2 FT #HET 170 170 TYR A 1 701 9QO A S 1 FT #HET 170 170 TYR A 2 702 NAP A S 2 FT #HET 172 172 GLU A 2 702 NAP A S 10 FT #HET 185 185 THR A 1 701 9QO A S 1 FT #HET 195 195 VAL A 2 702 NAP A S 2 FT #HET 345 345 ARG A 3 703 UMP A S 10 FT #HET 470 470 ARG A 6 703 UMP B S 12 FT #HET 471 471 ARG A 6 703 UMP B S 8 FT #HET 490 490 CYS A 3 703 UMP A S 4 FT #HET 491 491 HIS A 3 703 UMP A S 6 FT #HET 509 509 GLN A 3 703 UMP A S 3 FT #HET 510 510 ARG A 3 703 UMP A S 8 FT #HET 511 511 SER A 3 703 UMP A A 8 FT #HET 512 512 CYS A 3 703 UMP A B 2 FT #HET 513 513 ASP A 3 703 UMP A A 7 FT #HET 517 517 GLY A 3 703 UMP A B 1 FT #HET 521 521 ASN A 3 703 UMP A S 10 FT #HET 551 551 HIS A 3 703 UMP A S 7 FT #HET 553 553 TYR A 3 703 UMP A S 4 FT DISORDER 24 27 FT DISORDER 86 95 FT DISORDER 232 282 FT DISORDER 299 309 FT DISORDER 606 608 CC SEQUENCE 529 AA (ATOM); CC MMEQVCDVFD IYAICACCKV ESKKNEVFNN YTFRGLGNKG VLPWKCISLD MKYFRAVTTY CC VNESKYEKLK YKRCKYLNKE TKKLQNVVVM GRTNWESIPK KFKPLSNRIN VILSRTLKKE CC DFDEDVYIIN KVEDLIVLLG KLNYYKCFIL GGSVVYQEFL EKKLIKKIYF TRINSTYECD CC VFFPEINENE YQIISVSDVY TSNNTTLDFI IYKKTNNDDE EEDDFVYFNF NKENDFQIYN CC SLKYKYHPEY QYLNIIYDIM MNGNKQSDRT GVGVLSKFGY IMKFDLSQYF PLLTTKKLFL CC RGIIEELLWF IRGETNGNTL LNKNVRIWEA NGTREFLDNR KLFHREVNDL GPIYGFQWRH CC FGAEYTNMYD NYENKGVDQL KNIINLIKND PTSRRILLCA WNVKDLDQMA LPPCHILCQF CC YVFDGKLSCI MYQRSCDLGL GVPFNIASYS IFTHMIAQVC NLQPAQFIHV LGNAHVYNNH CC IDSLKIQLNR IPYPFPTLKL NPDIKNIEDF TISDFTIQNY VHHEKISMD CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MMEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKC CC ATOM MMEQVCDVFDIYAICACCKVESK----KNEVFNNYTFRGLGNKGVLPWKC CC *********************** *********************** CC SEQRES ISLDMKYFRAVTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKLQN CC ATOM ISLDMKYFRAVTTYVNESKYEKLKYKRCKYLNKET----------KKLQN CC *********************************** ***** CC SEQRES VVVMGRTNWESIPKKFKPLSNRINVILSRTLKKEDFDEDVYIINKVEDLI CC ATOM VVVMGRTNWESIPKKFKPLSNRINVILSRTLKKEDFDEDVYIINKVEDLI CC ************************************************** CC SEQRES VLLGKLNYYKCFILGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEI CC ATOM VLLGKLNYYKCFILGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEI CC ************************************************** CC SEQRES NENEYQIISVSDVYTSNNTTLDFIIYKKTNNKMLNEQNCIKGEEKNNDMP CC ATOM NENEYQIISVSDVYTSNNTTLDFIIYKKTNN------------------- CC ******************************* CC SEQRES LKNDDKDTCHMKKLTEFYKNVDKYKINYENDDDDEEEDDFVYFNFNKEKE CC ATOM --------------------------------DDEEEDDFVYFNFNKE-- CC **************** CC SEQRES EKNKNSIHPNDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGV CC ATOM ---------NDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGV CC ***************************************** CC SEQRES LSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKN CC ATOM LSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKN CC ************************************************** CC SEQRES VRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYEN CC ATOM VRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYEN CC ************************************************** CC SEQRES KGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFD CC ATOM KGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFD CC ************************************************** CC SEQRES GKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNA CC ATOM GKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNA CC ************************************************** CC SEQRES HVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHE CC ATOM HVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHE CC ************************************************** CC SEQRES KISMDMAA CC ATOM KISMD--- CC ***** SQ SEQUENCE 608 AA; MW; CN; MMEQVCDVFD IYAICACCKV ESKNEGKKNE VFNNYTFRGL GNKGVLPWKC ISLDMKYFRA VTTYVNESKY EKLKYKRCKY LNKETVDNVN DMPNSKKLQN VVVMGRTNWE SIPKKFKPLS NRINVILSRT LKKEDFDEDV YIINKVEDLI VLLGKLNYYK CFILGGSVVY QEFLEKKLIK KIYFTRINST YECDVFFPEI NENEYQIISV SDVYTSNNTT LDFIIYKKTN NKMLNEQNCI KGEEKNNDMP LKNDDKDTCH MKKLTEFYKN VDKYKINYEN DDDDEEEDDF VYFNFNKEKE EKNKNSIHPN DFQIYNSLKY KYHPEYQYLN IIYDIMMNGN KQSDRTGVGV LSKFGYIMKF DLSQYFPLLT TKKLFLRGII EELLWFIRGE TNGNTLLNKN VRIWEANGTR EFLDNRKLFH REVNDLGPIY GFQWRHFGAE YTNMYDNYEN KGVDQLKNII NLIKNDPTSR RILLCAWNVK DLDQMALPPC HILCQFYVFD GKLSCIMYQR SCDLGLGVPF NIASYSIFTH MIAQVCNLQP AQFIHVLGNA HVYNNHIDSL KIQLNRIPYP FPTLKLNPDI KNIEDFTISD FTIQNYVHHE KISMDMAA // ID 6A2LB STANDARD; PRT; 608 AA. DT CONVERTED FROM PDB (SEQRES) 6A2L DE Bifunctional dihydrofolate reductase-thymidylate synthase OS Plasmodium falciparum CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.380 CC R-Factor 0.200 FT #SUB 53 53 LEU B 295 295 PHE A Protein A 6 FT #SUB 53 53 LEU B 296 296 ASN A Protein S 3 FT #SUB 56 56 LYS B 295 295 PHE A Protein S 2 FT #SUB 56 56 LYS B 296 296 ASN A Protein S 3 FT #SUB 57 57 TYR B 292 292 TYR A Protein S 1 FT #SUB 57 57 TYR B 293 293 PHE A Protein S 1 FT #SUB 57 57 TYR B 295 295 PHE A Protein A 9 FT #SUB 61 61 VAL B 292 292 TYR A Protein A 7 FT #SUB 64 64 TYR B 288 288 ASP A Protein S 2 FT #SUB 64 64 TYR B 291 291 VAL A Protein S 1 FT #SUB 69 69 LYS B 284 284 ASP A Protein S 2 FT #SUB 69 69 LYS B 288 288 ASP A Protein S 3 FT #SUB 72 72 LYS B 284 284 ASP A Protein S 1 FT #SUB 159 159 TYR B 288 288 ASP A Protein S 5 FT #SUB 160 160 LYS B 288 288 ASP A Protein S 2 FT #SUB 181 181 LYS B 285 285 GLU A Protein S 4 FT #SUB 181 181 LYS B 286 286 GLU A Protein S 2 FT #SUB 181 181 LYS B 289 289 ASP A Protein S 4 FT #SUB 183 183 TYR B 289 289 ASP A Protein S 5 FT #SUB 183 183 TYR B 292 292 TYR A Protein S 4 FT #SUB 208 208 ILE B 286 286 GLU A Protein S 1 FT #SUB 209 209 SER B 293 293 PHE A Protein S 2 FT #SUB 210 210 VAL B 293 293 PHE A Protein B 2 FT #SUB 211 211 SER B 293 293 PHE A Protein S 1 FT #SUB 223 223 PHE B 293 293 PHE A Protein A 3 FT #SUB 223 223 PHE B 295 295 PHE A Protein S 3 FT #SUB 225 225 ILE B 289 289 ASP A Protein S 4 FT #SUB 225 225 ILE B 293 293 PHE A Protein S 2 FT #SUB 227 227 LYS B 286 286 GLU A Protein S 1 FT #SUB 284 284 ASP B 69 69 LYS A Protein A 6 FT #SUB 284 284 ASP B 72 72 LYS A Protein S 3 FT #SUB 285 285 GLU B 10 10 ASP A Protein S 1 FT #SUB 285 285 GLU B 12 12 TYR A Protein S 5 FT #SUB 285 285 GLU B 180 180 LYS A Protein S 6 FT #SUB 285 285 GLU B 181 181 LYS A Protein B 1 FT #SUB 286 286 GLU B 181 181 LYS A Protein S 4 FT #SUB 286 286 GLU B 227 227 LYS A Protein S 5 FT #SUB 286 286 GLU B 320 320 TYR A Protein B 4 FT #SUB 287 287 GLU B 69 69 LYS A Protein S 2 FT #SUB 288 288 ASP B 64 64 TYR A Protein S 2 FT #SUB 288 288 ASP B 69 69 LYS A Protein A 4 FT #SUB 288 288 ASP B 159 159 TYR A Protein S 5 FT #SUB 288 288 ASP B 160 160 LYS A Protein S 4 FT #SUB 289 289 ASP B 181 181 LYS A Protein S 4 FT #SUB 289 289 ASP B 183 183 TYR A Protein S 5 FT #SUB 289 289 ASP B 225 225 ILE A Protein S 5 FT #SUB 290 290 PHE B 320 320 TYR A Protein S 2 FT #SUB 290 290 PHE B 322 322 TYR A Protein S 2 FT #SUB 291 291 VAL B 64 64 TYR A Protein S 2 FT #SUB 292 292 TYR B 57 57 TYR A Protein B 2 FT #SUB 292 292 TYR B 61 61 VAL A Protein S 3 FT #SUB 292 292 TYR B 64 64 TYR A Protein S 1 FT #SUB 292 292 TYR B 160 160 LYS A Protein S 2 FT #SUB 292 292 TYR B 183 183 TYR A Protein S 6 FT #SUB 293 293 PHE B 57 57 TYR A Protein S 1 FT #SUB 293 293 PHE B 209 209 SER A Protein S 2 FT #SUB 293 293 PHE B 210 210 VAL A Protein S 2 FT #SUB 293 293 PHE B 211 211 SER A Protein S 3 FT #SUB 293 293 PHE B 223 223 PHE A Protein S 2 FT #SUB 293 293 PHE B 225 225 ILE A Protein S 2 FT #SUB 293 293 PHE B 320 320 TYR A Protein S 1 FT #SUB 293 293 PHE B 322 322 TYR A Protein S 3 FT #SUB 295 295 PHE B 53 53 LEU A Protein S 4 FT #SUB 295 295 PHE B 56 56 LYS A Protein B 1 FT #SUB 295 295 PHE B 57 57 TYR A Protein S 10 FT #SUB 295 295 PHE B 60 60 ALA A Protein S 1 FT #SUB 295 295 PHE B 214 214 TYR A Protein S 1 FT #SUB 295 295 PHE B 223 223 PHE A Protein S 3 FT #SUB 296 296 ASN B 53 53 LEU A Protein S 3 FT #SUB 296 296 ASN B 56 56 LYS A Protein S 3 FT #SUB 320 320 TYR B 286 286 GLU A Protein S 2 FT #SUB 320 320 TYR B 290 290 PHE A Protein S 3 FT #SUB 322 322 TYR B 290 290 PHE A Protein S 2 FT #SUB 322 322 TYR B 293 293 PHE A Protein S 2 FT #SUB 340 340 ASN B 497 497 TYR A Protein S 5 FT #SUB 340 340 ASN B 499 499 PHE A Protein S 14 FT #SUB 341 341 LYS B 499 499 PHE A Protein B 1 FT #SUB 342 342 GLN B 497 497 TYR A Protein S 4 FT #SUB 342 342 GLN B 498 498 VAL A Protein S 2 FT #SUB 342 342 GLN B 499 499 PHE A Protein S 3 FT #SUB 343 343 SER B 468 468 THR A Protein A 4 FT #SUB 344 344 ASP B 470 470 ARG A Protein S 5 FT #SUB 345 345 ARG B 471 471 ARG A Protein S 3 FT #SUB 352 352 SER B 497 497 TYR A Protein A 6 FT #SUB 354 354 PHE B 359 359 LYS A Protein B 1 FT #SUB 354 354 PHE B 495 495 GLN A Protein S 4 FT #SUB 354 354 PHE B 496 496 PHE A Protein S 2 FT #SUB 354 354 PHE B 497 497 TYR A Protein S 14 FT #SUB 354 354 PHE B 504 504 SER A Protein S 1 FT #SUB 354 354 PHE B 505 505 CYS A Protein S 1 FT #SUB 354 354 PHE B 506 506 ILE A Protein S 7 FT #SUB 354 354 PHE B 544 544 ILE A Protein A 2 FT #SUB 355 355 GLY B 359 359 LYS A Protein B 3 FT #SUB 355 355 GLY B 506 506 ILE A Protein B 2 FT #SUB 357 357 ILE B 357 357 ILE A Protein S 1 FT #SUB 359 359 LYS B 354 354 PHE A Protein S 1 FT #SUB 359 359 LYS B 355 355 GLY A Protein S 3 FT #SUB 416 416 ARG B 471 471 ARG A Protein S 1 FT #SUB 437 437 PHE B 478 478 ASN A Protein S 1 FT #SUB 437 437 PHE B 479 479 VAL A Protein S 12 FT #SUB 437 437 PHE B 480 480 LYS A Protein S 2 FT #SUB 438 438 GLY B 480 480 LYS A Protein B 1 FT #SUB 453 453 VAL B 479 479 VAL A Protein S 2 FT #SUB 455 455 GLN B 479 479 VAL A Protein S 4 FT #SUB 468 468 THR B 343 343 SER A Protein S 5 FT #SUB 470 470 ARG B 344 344 ASP A Protein S 5 FT #SUB 470 470 ARG B 510 510 ARG A Protein A 6 FT #SUB 470 470 ARG B 511 511 SER A Protein S 3 FT #SUB 470 470 ARG B 549 549 ASN A Protein S 4 FT #SUB 470 470 ARG B 551 551 HIS A Protein S 8 FT #SUB 470 470 ARG B 553 553 TYR A Protein S 3 FT #SUB 471 471 ARG B 345 345 ARG A Protein S 2 FT #SUB 471 471 ARG B 416 416 ARG A Protein S 1 FT #SUB 471 471 ARG B 488 488 PRO A Protein S 8 FT #SUB 471 471 ARG B 510 510 ARG A Protein S 2 FT #SUB 473 473 LEU B 477 477 TRP A Protein S 1 FT #SUB 473 473 LEU B 492 492 ILE A Protein S 1 FT #SUB 473 473 LEU B 510 510 ARG A Protein S 2 FT #SUB 475 475 CYS B 477 477 TRP A Protein S 1 FT #SUB 477 477 TRP B 473 473 LEU A Protein S 2 FT #SUB 477 477 TRP B 475 475 CYS A Protein S 2 FT #SUB 478 478 ASN B 437 437 PHE A Protein S 2 FT #SUB 479 479 VAL B 437 437 PHE A Protein A 11 FT #SUB 479 479 VAL B 453 453 VAL A Protein S 2 FT #SUB 479 479 VAL B 455 455 GLN A Protein S 4 FT #SUB 479 479 VAL B 475 475 CYS A Protein S 1 FT #SUB 480 480 LYS B 437 437 PHE A Protein B 2 FT #SUB 480 480 LYS B 438 438 GLY A Protein S 1 FT #SUB 488 488 PRO B 471 471 ARG A Protein S 3 FT #SUB 492 492 ILE B 473 473 LEU A Protein S 2 FT #SUB 492 492 ILE B 493 493 LEU A Protein S 1 FT #SUB 493 493 LEU B 492 492 ILE A Protein S 1 FT #SUB 493 493 LEU B 493 493 LEU A Protein S 1 FT #SUB 495 495 GLN B 354 354 PHE A Protein A 5 FT #SUB 495 495 GLN B 508 508 TYR A Protein S 5 FT #SUB 495 495 GLN B 510 510 ARG A Protein S 11 FT #SUB 495 495 GLN B 548 548 GLY A Protein S 1 FT #SUB 496 496 PHE B 354 354 PHE A Protein B 2 FT #SUB 497 497 TYR B 340 340 ASN A Protein S 5 FT #SUB 497 497 TYR B 342 342 GLN A Protein S 3 FT #SUB 497 497 TYR B 352 352 SER A Protein S 6 FT #SUB 497 497 TYR B 354 354 PHE A Protein S 14 FT #SUB 497 497 TYR B 549 549 ASN A Protein S 2 FT #SUB 498 498 VAL B 342 342 GLN A Protein B 3 FT #SUB 499 499 PHE B 340 340 ASN A Protein S 13 FT #SUB 499 499 PHE B 341 341 LYS A Protein S 2 FT #SUB 499 499 PHE B 342 342 GLN A Protein S 2 FT #SUB 504 504 SER B 354 354 PHE A Protein A 3 FT #SUB 505 505 CYS B 354 354 PHE A Protein B 2 FT #SUB 506 506 ILE B 354 354 PHE A Protein A 7 FT #SUB 506 506 ILE B 355 355 GLY A Protein S 1 FT #SUB 506 506 ILE B 508 508 TYR A Protein S 4 FT #SUB 506 506 ILE B 548 548 GLY A Protein S 1 FT #SUB 508 508 TYR B 495 495 GLN A Protein S 5 FT #SUB 508 508 TYR B 506 506 ILE A Protein S 4 FT #SUB 510 510 ARG B 470 470 ARG A Protein S 7 FT #SUB 510 510 ARG B 471 471 ARG A Protein S 1 FT #SUB 510 510 ARG B 473 473 LEU A Protein S 2 FT #SUB 510 510 ARG B 495 495 GLN A Protein A 10 FT #SUB 511 511 SER B 470 470 ARG A Protein S 2 FT #SUB 544 544 ILE B 354 354 PHE A Protein S 2 FT #SUB 546 546 VAL B 546 546 VAL A Protein S 1 FT #SUB 548 548 GLY B 495 495 GLN A Protein B 1 FT #SUB 548 548 GLY B 506 506 ILE A Protein B 1 FT #SUB 549 549 ASN B 470 470 ARG A Protein S 5 FT #SUB 549 549 ASN B 497 497 TYR A Protein S 2 FT #SUB 551 551 HIS B 470 470 ARG A Protein S 9 FT #SUB 553 553 TYR B 470 470 ARG A Protein S 3 FT #HET 14 14 ILE B 4 701 9QO B A 7 FT #HET 15 15 CYS B 4 701 9QO B B 8 FT #HET 15 15 CYS B 5 702 NAP B A 3 FT #HET 16 16 ALA B 4 701 9QO B A 6 FT #HET 16 16 ALA B 5 702 NAP B B 7 FT #HET 40 40 LEU B 5 702 NAP B A 8 FT #HET 41 41 GLY B 5 702 NAP B B 1 FT #HET 42 42 ASN B 5 702 NAP B B 1 FT #HET 44 44 GLY B 5 702 NAP B B 6 FT #HET 45 45 VAL B 5 702 NAP B B 8 FT #HET 46 46 LEU B 4 701 9QO B S 1 FT #HET 46 46 LEU B 5 702 NAP B A 2 FT #HET 48 48 TRP B 4 701 9QO B S 1 FT #HET 54 54 ASP B 4 701 9QO B S 11 FT #HET 55 55 MET B 4 701 9QO B S 4 FT #HET 58 58 PHE B 4 701 9QO B S 12 FT #HET 105 105 GLY B 5 702 NAP B B 4 FT #HET 106 106 ARG B 5 702 NAP B A 16 FT #HET 107 107 THR B 5 702 NAP B A 15 FT #HET 108 108 ASN B 4 701 9QO B S 3 FT #HET 108 108 ASN B 5 702 NAP B A 8 FT #HET 111 111 SER B 4 701 9QO B S 1 FT #HET 112 112 ILE B 4 701 9QO B S 2 FT #HET 116 116 PHE B 4 701 9QO B S 13 FT #HET 119 119 LEU B 4 701 9QO B S 1 FT #HET 127 127 LEU B 5 702 NAP B A 10 FT #HET 128 128 SER B 5 702 NAP B A 8 FT #HET 129 129 ARG B 5 702 NAP B A 18 FT #HET 130 130 THR B 5 702 NAP B A 9 FT #HET 144 144 ASN B 5 702 NAP B B 3 FT #HET 164 164 LEU B 4 701 9QO B A 3 FT #HET 164 164 LEU B 5 702 NAP B B 2 FT #HET 165 165 GLY B 5 702 NAP B B 5 FT #HET 166 166 GLY B 5 702 NAP B B 13 FT #HET 167 167 SER B 5 702 NAP B A 8 FT #HET 168 168 VAL B 5 702 NAP B A 7 FT #HET 169 169 VAL B 5 702 NAP B A 3 FT #HET 170 170 TYR B 4 701 9QO B S 1 FT #HET 170 170 TYR B 5 702 NAP B S 2 FT #HET 172 172 GLU B 5 702 NAP B S 9 FT #HET 185 185 THR B 4 701 9QO B S 1 FT #HET 195 195 VAL B 5 702 NAP B S 1 FT #HET 345 345 ARG B 6 703 UMP B S 9 FT #HET 470 470 ARG B 3 703 UMP A S 14 FT #HET 471 471 ARG B 3 703 UMP A S 8 FT #HET 490 490 CYS B 6 703 UMP B S 4 FT #HET 491 491 HIS B 6 703 UMP B S 4 FT #HET 509 509 GLN B 6 703 UMP B S 3 FT #HET 510 510 ARG B 6 703 UMP B S 6 FT #HET 511 511 SER B 6 703 UMP B A 8 FT #HET 512 512 CYS B 6 703 UMP B B 2 FT #HET 513 513 ASP B 6 703 UMP B A 8 FT #HET 517 517 GLY B 6 703 UMP B B 2 FT #HET 521 521 ASN B 6 703 UMP B S 10 FT #HET 551 551 HIS B 6 703 UMP B S 6 FT #HET 553 553 TYR B 6 703 UMP B S 4 FT DISORDER 22 28 FT DISORDER 81 95 FT DISORDER 232 282 FT DISORDER 299 309 FT DISORDER 606 608 CC SEQUENCE 521 AA (ATOM); CC MMEQVCDVFD IYAICACCKV ENEVFNNYTF RGLGNKGVLP WKCISLDMKY FRAVTTYVNE CC SKYEKLKYKR CKYKKLQNVV VMGRTNWESI PKKFKPLSNR INVILSRTLK KEDFDEDVYI CC INKVEDLIVL LGKLNYYKCF ILGGSVVYQE FLEKKLIKKI YFTRINSTYE CDVFFPEINE CC NEYQIISVSD VYTSNNTTLD FIIYKKTNND DEEEDDFVYF NFNKENDFQI YNSLKYKYHP CC EYQYLNIIYD IMMNGNKQSD RTGVGVLSKF GYIMKFDLSQ YFPLLTTKKL FLRGIIEELL CC WFIRGETNGN TLLNKNVRIW EANGTREFLD NRKLFHREVN DLGPIYGFQW RHFGAEYTNM CC YDNYENKGVD QLKNIINLIK NDPTSRRILL CAWNVKDLDQ MALPPCHILC QFYVFDGKLS CC CIMYQRSCDL GLGVPFNIAS YSIFTHMIAQ VCNLQPAQFI HVLGNAHVYN NHIDSLKIQL CC NRIPYPFPTL KLNPDIKNIE DFTISDFTIQ NYVHHEKISM D CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MMEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKC CC ATOM MMEQVCDVFDIYAICACCKVE-------NEVFNNYTFRGLGNKGVLPWKC CC ********************* ********************** CC SEQRES ISLDMKYFRAVTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKLQN CC ATOM ISLDMKYFRAVTTYVNESKYEKLKYKRCKY---------------KKLQN CC ****************************** ***** CC SEQRES VVVMGRTNWESIPKKFKPLSNRINVILSRTLKKEDFDEDVYIINKVEDLI CC ATOM VVVMGRTNWESIPKKFKPLSNRINVILSRTLKKEDFDEDVYIINKVEDLI CC ************************************************** CC SEQRES VLLGKLNYYKCFILGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEI CC ATOM VLLGKLNYYKCFILGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEI CC ************************************************** CC SEQRES NENEYQIISVSDVYTSNNTTLDFIIYKKTNNKMLNEQNCIKGEEKNNDMP CC ATOM NENEYQIISVSDVYTSNNTTLDFIIYKKTNN------------------- CC ******************************* CC SEQRES LKNDDKDTCHMKKLTEFYKNVDKYKINYENDDDDEEEDDFVYFNFNKEKE CC ATOM --------------------------------DDEEEDDFVYFNFNKE-- CC **************** CC SEQRES EKNKNSIHPNDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGV CC ATOM ---------NDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGV CC ***************************************** CC SEQRES LSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKN CC ATOM LSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKN CC ************************************************** CC SEQRES VRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYEN CC ATOM VRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYEN CC ************************************************** CC SEQRES KGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFD CC ATOM KGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFD CC ************************************************** CC SEQRES GKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNA CC ATOM GKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNA CC ************************************************** CC SEQRES HVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHE CC ATOM HVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHE CC ************************************************** CC SEQRES KISMDMAA CC ATOM KISMD--- CC ***** SQ SEQUENCE 608 AA; MW; CN; MMEQVCDVFD IYAICACCKV ESKNEGKKNE VFNNYTFRGL GNKGVLPWKC ISLDMKYFRA VTTYVNESKY EKLKYKRCKY LNKETVDNVN DMPNSKKLQN VVVMGRTNWE SIPKKFKPLS NRINVILSRT LKKEDFDEDV YIINKVEDLI VLLGKLNYYK CFILGGSVVY QEFLEKKLIK KIYFTRINST YECDVFFPEI NENEYQIISV SDVYTSNNTT LDFIIYKKTN NKMLNEQNCI KGEEKNNDMP LKNDDKDTCH MKKLTEFYKN VDKYKINYEN DDDDEEEDDF VYFNFNKEKE EKNKNSIHPN DFQIYNSLKY KYHPEYQYLN IIYDIMMNGN KQSDRTGVGV LSKFGYIMKF DLSQYFPLLT TKKLFLRGII EELLWFIRGE TNGNTLLNKN VRIWEANGTR EFLDNRKLFH REVNDLGPIY GFQWRHFGAE YTNMYDNYEN KGVDQLKNII NLIKNDPTSR RILLCAWNVK DLDQMALPPC HILCQFYVFD GKLSCIMYQR SCDLGLGVPF NIASYSIFTH MIAQVCNLQP AQFIHVLGNA HVYNNHIDSL KIQLNRIPYP FPTLKLNPDI KNIEDFTISD FTIQNYVHHE KISMDMAA //