ID 5Y8MA STANDARD; PRT; 295 AA. DT CONVERTED FROM PDB (SEQRES) 5Y8M DE Probable 3-hydroxyisobutyrate dehydrogenase OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.040 CC R-Factor 0.154 FT #SUB 101 100 ARG A 193 192 LEU B Protein S 5 FT #SUB 159 158 CYS A 195 194 LEU B Protein B 1 FT #SUB 159 158 CYS A 199 198 SER B Protein B 2 FT #SUB 159 158 CYS A 203 202 VAL B Protein S 1 FT #SUB 164 163 ALA A 195 194 LEU B Protein B 1 FT #SUB 167 166 ALA A 193 192 LEU B Protein S 1 FT #SUB 167 166 ALA A 195 194 LEU B Protein B 1 FT #SUB 168 167 ALA A 195 194 LEU B Protein B 2 FT #SUB 171 170 CYS A 186 185 ALA B Protein S 1 FT #SUB 171 170 CYS A 200 199 LEU B Protein S 1 FT #SUB 172 171 ASN A 204 203 ILE B Protein S 3 FT #SUB 172 171 ASN A 207 206 ALA B Protein S 2 FT #SUB 172 171 ASN A 208 207 THR B Protein S 3 FT #SUB 172 171 ASN A 209 208 GLY B Protein S 4 FT #SUB 174 173 MET A 189 188 LEU B Protein S 1 FT #SUB 175 174 VAL A 182 181 ALA B Protein S 1 FT #SUB 175 174 VAL A 183 182 ILE B Protein S 1 FT #SUB 175 174 VAL A 186 185 ALA B Protein S 1 FT #SUB 175 174 VAL A 209 208 GLY B Protein S 1 FT #SUB 176 175 LEU A 208 207 THR B Protein S 1 FT #SUB 178 177 VAL A 178 177 VAL B Protein S 1 FT #SUB 178 177 VAL A 182 181 ALA B Protein S 1 FT #SUB 178 177 VAL A 262 261 LEU B Protein A 3 FT #SUB 179 178 GLN A 208 207 THR B Protein S 1 FT #SUB 179 178 GLN A 209 208 GLY B Protein S 6 FT #SUB 179 178 GLN A 211 210 CYS B Protein S 2 FT #SUB 181 180 ILE A 262 261 LEU B Protein S 3 FT #SUB 182 181 ALA A 175 174 VAL B Protein B 1 FT #SUB 182 181 ALA A 178 177 VAL B Protein S 2 FT #SUB 185 184 GLU A 260 259 ALA B Protein S 9 FT #SUB 185 184 GLU A 261 260 PRO B Protein S 9 FT #SUB 185 184 GLU A 262 261 LEU B Protein S 9 FT #SUB 185 184 GLU A 263 262 GLY B Protein S 4 FT #SUB 186 185 ALA A 171 170 CYS B Protein B 1 FT #SUB 186 185 ALA A 175 174 VAL B Protein S 1 FT #SUB 189 188 LEU A 174 173 MET B Protein S 1 FT #SUB 189 188 LEU A 252 251 ALA B Protein S 2 FT #SUB 189 188 LEU A 256 255 THR B Protein S 1 FT #SUB 189 188 LEU A 258 257 ALA B Protein S 1 FT #SUB 192 191 LYS A 256 255 THR B Protein A 5 FT #SUB 192 191 LYS A 258 257 ALA B Protein S 2 FT #SUB 193 192 LEU A 101 100 ARG B Protein B 4 FT #SUB 193 192 LEU A 167 166 ALA B Protein S 1 FT #SUB 193 192 LEU A 256 255 THR B Protein S 2 FT #SUB 195 194 LEU A 159 158 CYS B Protein S 1 FT #SUB 195 194 LEU A 167 166 ALA B Protein S 2 FT #SUB 195 194 LEU A 168 167 ALA B Protein S 2 FT #SUB 199 198 SER A 159 158 CYS B Protein S 3 FT #SUB 200 199 LEU A 171 170 CYS B Protein S 1 FT #SUB 202 201 ASP A 157 156 ILE B Protein S 1 FT #SUB 203 202 VAL A 157 156 ILE B Protein A 2 FT #SUB 203 202 VAL A 159 158 CYS B Protein S 1 FT #SUB 203 202 VAL A 168 167 ALA B Protein S 1 FT #SUB 204 203 ILE A 172 171 ASN B Protein A 3 FT #SUB 204 203 ILE A 175 174 VAL B Protein S 1 FT #SUB 207 206 ALA A 172 171 ASN B Protein S 2 FT #SUB 208 207 THR A 172 171 ASN B Protein A 2 FT #SUB 208 207 THR A 176 175 LEU B Protein S 1 FT #SUB 208 207 THR A 179 178 GLN B Protein B 1 FT #SUB 208 207 THR A 212 211 TRP B Protein A 6 FT #SUB 209 208 GLY A 172 171 ASN B Protein B 4 FT #SUB 209 208 GLY A 175 174 VAL B Protein B 1 FT #SUB 209 208 GLY A 179 178 GLN B Protein B 6 FT #SUB 210 209 ASN A 211 210 CYS B Protein B 2 FT #SUB 211 210 CYS A 179 178 GLN B Protein S 2 FT #SUB 211 210 CYS A 210 209 ASN B Protein A 2 FT #SUB 212 211 TRP A 208 207 THR B Protein S 4 FT #SUB 252 251 ALA A 189 188 LEU B Protein B 1 FT #SUB 256 255 THR A 189 188 LEU B Protein S 1 FT #SUB 256 255 THR A 192 191 LYS B Protein A 5 FT #SUB 256 255 THR A 193 192 LEU B Protein S 1 FT #SUB 258 257 ALA A 192 191 LYS B Protein A 3 FT #SUB 259 258 THR A 289 288 LEU B Protein A 4 FT #SUB 260 259 ALA A 185 184 GLU B Protein A 9 FT #SUB 261 260 PRO A 185 184 GLU B Protein A 7 FT #SUB 261 260 PRO A 265 264 HIS B Protein A 3 FT #SUB 261 260 PRO A 269 268 ILE B Protein S 1 FT #SUB 261 260 PRO A 289 288 LEU B Protein S 1 FT #SUB 262 261 LEU A 178 177 VAL B Protein S 3 FT #SUB 262 261 LEU A 181 180 ILE B Protein S 3 FT #SUB 262 261 LEU A 185 184 GLU B Protein A 9 FT #SUB 262 261 LEU A 265 264 HIS B Protein S 3 FT #SUB 263 262 GLY A 185 184 GLU B Protein B 4 FT #SUB 265 264 HIS A 261 260 PRO B Protein S 3 FT #SUB 265 264 HIS A 262 261 LEU B Protein S 4 FT #SUB 265 264 HIS A 265 264 HIS B Protein S 5 FT #SUB 289 288 LEU A 259 258 THR B Protein A 7 FT #SUB 290 289 ARG A 257 256 GLY B Protein S 4 FT #SUB 290 289 ARG A 259 258 THR B Protein A 3 FT #HET 11 10 GLY A 3 303 GOL A B 2 FT #HET 12 11 ASN A 3 303 GOL A A 11 FT #HET 13 12 MET A 2 302 GOL A S 1 FT #HET 13 12 MET A 3 303 GOL A S 2 FT #HET 22 21 VAL A 1 301 GOL A S 1 FT #HET 26 25 HIS A 1 301 GOL A B 2 FT #HET 27 26 VAL A 1 301 GOL A A 7 FT #HET 28 27 VAL A 1 301 GOL A A 5 FT #HET 45 44 GLY A 1 301 GOL A B 4 FT #HET 59 58 ALA A 4 304 AKR A B 3 FT #HET 60 59 ASP A 4 304 AKR A A 7 FT #HET 65 64 MET A 2 302 GOL A S 3 FT #HET 66 65 LEU A 2 302 GOL A B 1 FT #HET 84 83 ARG A 4 304 AKR A A 11 FT #HET 85 84 PRO A 4 304 AKR A B 3 FT #HET 86 85 ALA A 4 304 AKR A B 2 FT #HET 87 86 THR A 4 304 AKR A A 8 FT #HET 94 93 THR A 2 302 GOL A S 1 FT #HET 119 118 VAL A 2 302 GOL A A 2 FT #HET 144 143 ARG A 4 304 AKR A S 1 FT #HET 146 145 ARG A 5 305 9ON A S 5 FT #HET 150 149 GLU A 5 305 9ON A A 8 FT #HET 153 152 ALA A 5 305 9ON A B 8 FT #HET 154 153 GLY A 5 305 9ON A B 3 FT #HET 155 154 LYS A 5 305 9ON A B 3 FT #HET 156 155 ILE A 5 305 9ON A B 1 FT #HET 169 168 LYS A 2 302 GOL A S 1 FT #HET 208 207 THR A 7 302 HIU B S 1 FT #HET 244 243 LYS A 2 302 GOL A S 2 FT DISORDER 1 2 FT DISORDER 292 295 CC SEQUENCE 289 AA (ATOM); CC TTIAFLGLGN MGAPMSANLV GAGHVVRGFD PAPTAASGAA AHGVAVFRSA PEAVAEADVV CC ITMLPTGEVV RRCYTDVLAA ARPATLFIDS STISVTDARE VHALAESHGM LQLDAPVSGG CC VKGAAAATLA FMVGGDESTL RRARPVLEPM AGKIIHCGAA GAGQAAKVCN NMVLAVQQIA CC IAEAFVLAEK LGLSAQSLFD VITGATGNCW AVHTNCPVPG PVPTSPANND FKPGFSTALM CC NKDLGLAMDA VAATGATAPL GSHAADIYAK FAADHADLDF SAVIHTLRA CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MMTTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAVFR CC ATOM --TTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAVFR CC ************************************************ CC SEQRES SAPEAVAEADVVITMLPTGEVVRRCYTDVLAAARPATLFIDSSTISVTDA CC ATOM SAPEAVAEADVVITMLPTGEVVRRCYTDVLAAARPATLFIDSSTISVTDA CC ************************************************** CC SEQRES REVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRRARPVLE CC ATOM REVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRRARPVLE CC ************************************************** CC SEQRES PMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLGLSAQSL CC ATOM PMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLGLSAQSL CC ************************************************** CC SEQRES FDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTALMNKDLGLAM CC ATOM FDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTALMNKDLGLAM CC ************************************************** CC SEQRES DAVAATGATAPLGSHAADIYAKFAADHADLDFSAVIHTLRARADA CC ATOM DAVAATGATAPLGSHAADIYAKFAADHADLDFSAVIHTLRA---- CC ***************************************** SQ SEQUENCE 295 AA; MW; CN; MMTTIAFLGL GNMGAPMSAN LVGAGHVVRG FDPAPTAASG AAAHGVAVFR SAPEAVAEAD VVITMLPTGE VVRRCYTDVL AAARPATLFI DSSTISVTDA REVHALAESH GMLQLDAPVS GGVKGAAAAT LAFMVGGDES TLRRARPVLE PMAGKIIHCG AAGAGQAAKV CNNMVLAVQQ IAIAEAFVLA EKLGLSAQSL FDVITGATGN CWAVHTNCPV PGPVPTSPAN NDFKPGFSTA LMNKDLGLAM DAVAATGATA PLGSHAADIY AKFAADHADL DFSAVIHTLR ARADA // ID 5Y8MB STANDARD; PRT; 295 AA. DT CONVERTED FROM PDB (SEQRES) 5Y8M DE Probable 3-hydroxyisobutyrate dehydrogenase OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.040 CC R-Factor 0.154 FT #SUB 101 100 ARG B 193 192 LEU A Protein S 4 FT #SUB 157 156 ILE B 202 201 ASP A Protein S 1 FT #SUB 157 156 ILE B 203 202 VAL A Protein S 2 FT #SUB 159 158 CYS B 195 194 LEU A Protein B 1 FT #SUB 159 158 CYS B 199 198 SER A Protein B 3 FT #SUB 159 158 CYS B 203 202 VAL A Protein S 1 FT #SUB 167 166 ALA B 193 192 LEU A Protein S 1 FT #SUB 167 166 ALA B 195 194 LEU A Protein A 2 FT #SUB 168 167 ALA B 195 194 LEU A Protein B 2 FT #SUB 168 167 ALA B 203 202 VAL A Protein S 1 FT #SUB 171 170 CYS B 186 185 ALA A Protein S 1 FT #SUB 171 170 CYS B 200 199 LEU A Protein S 1 FT #SUB 172 171 ASN B 204 203 ILE A Protein S 3 FT #SUB 172 171 ASN B 207 206 ALA A Protein S 2 FT #SUB 172 171 ASN B 208 207 THR A Protein S 2 FT #SUB 172 171 ASN B 209 208 GLY A Protein S 4 FT #SUB 174 173 MET B 189 188 LEU A Protein S 1 FT #SUB 175 174 VAL B 182 181 ALA A Protein S 1 FT #SUB 175 174 VAL B 186 185 ALA A Protein S 1 FT #SUB 175 174 VAL B 204 203 ILE A Protein S 1 FT #SUB 175 174 VAL B 209 208 GLY A Protein S 1 FT #SUB 176 175 LEU B 208 207 THR A Protein S 1 FT #SUB 178 177 VAL B 178 177 VAL A Protein S 1 FT #SUB 178 177 VAL B 182 181 ALA A Protein S 2 FT #SUB 178 177 VAL B 262 261 LEU A Protein A 3 FT #SUB 179 178 GLN B 208 207 THR A Protein S 1 FT #SUB 179 178 GLN B 209 208 GLY A Protein S 6 FT #SUB 179 178 GLN B 211 210 CYS A Protein S 2 FT #SUB 181 180 ILE B 262 261 LEU A Protein S 3 FT #SUB 182 181 ALA B 175 174 VAL A Protein B 1 FT #SUB 182 181 ALA B 178 177 VAL A Protein S 1 FT #SUB 183 182 ILE B 175 174 VAL A Protein S 1 FT #SUB 185 184 GLU B 260 259 ALA A Protein S 9 FT #SUB 185 184 GLU B 261 260 PRO A Protein S 7 FT #SUB 185 184 GLU B 262 261 LEU A Protein S 9 FT #SUB 185 184 GLU B 263 262 GLY A Protein S 4 FT #SUB 186 185 ALA B 171 170 CYS A Protein B 1 FT #SUB 186 185 ALA B 175 174 VAL A Protein S 1 FT #SUB 189 188 LEU B 174 173 MET A Protein S 1 FT #SUB 189 188 LEU B 252 251 ALA A Protein S 1 FT #SUB 189 188 LEU B 256 255 THR A Protein S 1 FT #SUB 192 191 LYS B 256 255 THR A Protein A 5 FT #SUB 192 191 LYS B 258 257 ALA A Protein S 3 FT #SUB 193 192 LEU B 101 100 ARG A Protein B 5 FT #SUB 193 192 LEU B 167 166 ALA A Protein S 1 FT #SUB 193 192 LEU B 256 255 THR A Protein S 1 FT #SUB 195 194 LEU B 159 158 CYS A Protein S 1 FT #SUB 195 194 LEU B 164 163 ALA A Protein S 1 FT #SUB 195 194 LEU B 167 166 ALA A Protein S 1 FT #SUB 195 194 LEU B 168 167 ALA A Protein S 2 FT #SUB 199 198 SER B 159 158 CYS A Protein S 2 FT #SUB 200 199 LEU B 171 170 CYS A Protein S 1 FT #SUB 203 202 VAL B 159 158 CYS A Protein S 1 FT #SUB 204 203 ILE B 172 171 ASN A Protein A 3 FT #SUB 207 206 ALA B 172 171 ASN A Protein S 2 FT #SUB 208 207 THR B 172 171 ASN A Protein A 3 FT #SUB 208 207 THR B 176 175 LEU A Protein S 1 FT #SUB 208 207 THR B 179 178 GLN A Protein B 1 FT #SUB 208 207 THR B 212 211 TRP A Protein A 4 FT #SUB 209 208 GLY B 172 171 ASN A Protein B 4 FT #SUB 209 208 GLY B 175 174 VAL A Protein B 1 FT #SUB 209 208 GLY B 179 178 GLN A Protein B 6 FT #SUB 210 209 ASN B 211 210 CYS A Protein B 2 FT #SUB 211 210 CYS B 179 178 GLN A Protein S 2 FT #SUB 211 210 CYS B 210 209 ASN A Protein A 2 FT #SUB 212 211 TRP B 208 207 THR A Protein S 6 FT #SUB 252 251 ALA B 189 188 LEU A Protein B 2 FT #SUB 256 255 THR B 189 188 LEU A Protein S 1 FT #SUB 256 255 THR B 192 191 LYS A Protein A 5 FT #SUB 256 255 THR B 193 192 LEU A Protein S 2 FT #SUB 257 256 GLY B 290 289 ARG A Protein B 4 FT #SUB 258 257 ALA B 189 188 LEU A Protein S 1 FT #SUB 258 257 ALA B 192 191 LYS A Protein A 2 FT #SUB 259 258 THR B 289 288 LEU A Protein A 7 FT #SUB 259 258 THR B 290 289 ARG A Protein S 3 FT #SUB 260 259 ALA B 185 184 GLU A Protein A 9 FT #SUB 261 260 PRO B 185 184 GLU A Protein A 9 FT #SUB 261 260 PRO B 265 264 HIS A Protein A 3 FT #SUB 262 261 LEU B 178 177 VAL A Protein S 3 FT #SUB 262 261 LEU B 181 180 ILE A Protein S 3 FT #SUB 262 261 LEU B 185 184 GLU A Protein A 9 FT #SUB 262 261 LEU B 265 264 HIS A Protein S 4 FT #SUB 263 262 GLY B 185 184 GLU A Protein B 4 FT #SUB 265 264 HIS B 261 260 PRO A Protein S 3 FT #SUB 265 264 HIS B 262 261 LEU A Protein S 3 FT #SUB 265 264 HIS B 265 264 HIS A Protein S 5 FT #SUB 269 268 ILE B 261 260 PRO A Protein S 1 FT #SUB 289 288 LEU B 259 258 THR A Protein A 4 FT #SUB 289 288 LEU B 261 260 PRO A Protein S 1 FT #HET 8 7 LEU B 6 301 NAD B B 1 FT #HET 9 8 GLY B 6 301 NAD B B 4 FT #HET 11 10 GLY B 6 301 NAD B B 8 FT #HET 12 11 ASN B 6 301 NAD B A 9 FT #HET 13 12 MET B 6 301 NAD B A 16 FT #HET 14 13 GLY B 6 301 NAD B B 1 FT #HET 31 30 PHE B 6 301 NAD B A 6 FT #HET 32 31 ASP B 6 301 NAD B A 18 FT #HET 33 32 PRO B 6 301 NAD B S 9 FT #HET 34 33 ALA B 6 301 NAD B A 2 FT #HET 37 36 ALA B 6 301 NAD B S 1 FT #HET 65 64 MET B 6 301 NAD B A 6 FT #HET 66 65 LEU B 6 301 NAD B A 15 FT #HET 67 66 PRO B 6 301 NAD B B 2 FT #HET 71 70 VAL B 6 301 NAD B S 2 FT #HET 75 74 CYS B 6 301 NAD B S 1 FT #HET 93 92 SER B 6 301 NAD B A 3 FT #HET 94 93 THR B 6 301 NAD B A 8 FT #HET 119 118 VAL B 6 301 NAD B B 2 FT #HET 120 119 SER B 7 302 HIU B A 3 FT #HET 121 120 GLY B 7 302 HIU B B 2 FT #HET 122 121 GLY B 6 301 NAD B B 3 FT #HET 123 122 VAL B 6 301 NAD B B 1 FT #HET 129 128 ALA B 8 303 9ON B B 1 FT #HET 150 149 GLU B 8 303 9ON B A 6 FT #HET 153 152 ALA B 8 303 9ON B A 11 FT #HET 154 153 GLY B 8 303 9ON B B 4 FT #HET 155 154 LYS B 8 303 9ON B B 2 FT #HET 169 168 LYS B 6 301 NAD B S 2 FT #HET 212 211 TRP B 7 302 HIU B S 1 FT #HET 237 236 PHE B 7 302 HIU B S 2 FT #HET 241 240 LEU B 6 301 NAD B S 5 FT #HET 244 243 LYS B 6 301 NAD B S 6 FT DISORDER 1 1 FT DISORDER 291 295 CC SEQUENCE 289 AA (ATOM); CC MTTIAFLGLG NMGAPMSANL VGAGHVVRGF DPAPTAASGA AAHGVAVFRS APEAVAEADV CC VITMLPTGEV VRRCYTDVLA AARPATLFID SSTISVTDAR EVHALAESHG MLQLDAPVSG CC GVKGAAAATL AFMVGGDEST LRRARPVLEP MAGKIIHCGA AGAGQAAKVC NNMVLAVQQI CC AIAEAFVLAE KLGLSAQSLF DVITGATGNC WAVHTNCPVP GPVPTSPANN DFKPGFSTAL CC MNKDLGLAMD AVAATGATAP LGSHAADIYA KFAADHADLD FSAVIHTLR CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MMTTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAVFR CC ATOM -MTTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAVFR CC ************************************************* CC SEQRES SAPEAVAEADVVITMLPTGEVVRRCYTDVLAAARPATLFIDSSTISVTDA CC ATOM SAPEAVAEADVVITMLPTGEVVRRCYTDVLAAARPATLFIDSSTISVTDA CC ************************************************** CC SEQRES REVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRRARPVLE CC ATOM REVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRRARPVLE CC ************************************************** CC SEQRES PMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLGLSAQSL CC ATOM PMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLGLSAQSL CC ************************************************** CC SEQRES FDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTALMNKDLGLAM CC ATOM FDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTALMNKDLGLAM CC ************************************************** CC SEQRES DAVAATGATAPLGSHAADIYAKFAADHADLDFSAVIHTLRARADA CC ATOM DAVAATGATAPLGSHAADIYAKFAADHADLDFSAVIHTLR----- CC **************************************** SQ SEQUENCE 295 AA; MW; CN; MMTTIAFLGL GNMGAPMSAN LVGAGHVVRG FDPAPTAASG AAAHGVAVFR SAPEAVAEAD VVITMLPTGE VVRRCYTDVL AAARPATLFI DSSTISVTDA REVHALAESH GMLQLDAPVS GGVKGAAAAT LAFMVGGDES TLRRARPVLE PMAGKIIHCG AAGAGQAAKV CNNMVLAVQQ IAIAEAFVLA EKLGLSAQSL FDVITGATGN CWAVHTNCPV PGPVPTSPAN NDFKPGFSTA LMNKDLGLAM DAVAATGATA PLGSHAADIY AKFAADHADL DFSAVIHTLR ARADA //