ID	5WRNB	STANDARD;	PRT;	289	AA.
DT	CONVERTED FROM PDB (SEQRES) 5WRN
DE	Thymidylate synthase
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.390
CC	R-Factor	0.191
FT	#SUB	21	  45 	VAL	B	180	 204 	VAL	A	Protein	S	1
FT	#SUB	21	  45 	VAL	B	181	 205 	ASN	A	Protein	S	1
FT	#SUB	23	  47 	LYS	B	149	 173 	ASP	A	Protein	S	4
FT	#SUB	23	  47 	LYS	B	178	 202 	TYR	A	Protein	S	7
FT	#SUB	23	  47 	LYS	B	179	 203 	VAL	A	Protein	S	2
FT	#SUB	24	  48 	ASP	B	149	 173 	ASP	A	Protein	B	2
FT	#SUB	31	  55 	THR	B	151	 175 	ARG	A	Protein	S	1
FT	#SUB	33	  57 	SER	B	178	 202 	TYR	A	Protein	A	6
FT	#SUB	35	  59 	PHE	B	40	  64 	ARG	A	Protein	B	4
FT	#SUB	35	  59 	PHE	B	176	 200 	GLN	A	Protein	S	2
FT	#SUB	35	  59 	PHE	B	178	 202 	TYR	A	Protein	S	15
FT	#SUB	35	  59 	PHE	B	185	 209 	SER	A	Protein	S	1
FT	#SUB	35	  59 	PHE	B	186	 210 	CYS	A	Protein	S	2
FT	#SUB	35	  59 	PHE	B	187	 211 	GLN	A	Protein	S	3
FT	#SUB	35	  59 	PHE	B	225	 249 	ILE	A	Protein	A	4
FT	#SUB	36	  60 	GLY	B	38	  62 	GLN	A	Protein	B	2
FT	#SUB	36	  60 	GLY	B	40	  64 	ARG	A	Protein	B	3
FT	#SUB	36	  60 	GLY	B	187	 211 	GLN	A	Protein	B	1
FT	#SUB	37	  61 	MET	B	38	  62 	GLN	A	Protein	B	10
FT	#SUB	38	  62 	GLN	B	36	  60 	GLY	A	Protein	S	2
FT	#SUB	38	  62 	GLN	B	37	  61 	MET	A	Protein	S	8
FT	#SUB	38	  62 	GLN	B	38	  62 	GLN	A	Protein	A	8
FT	#SUB	38	  62 	GLN	B	227	 251 	THR	A	Protein	S	1
FT	#SUB	40	  64 	ARG	B	35	  59 	PHE	A	Protein	S	4
FT	#SUB	40	  64 	ARG	B	36	  60 	GLY	A	Protein	S	3
FT	#SUB	118	 142 	PHE	B	159	 183 	ASN	A	Protein	S	1
FT	#SUB	118	 142 	PHE	B	160	 184 	PRO	A	Protein	S	6
FT	#SUB	119	 143 	GLY	B	161	 185 	ARG	A	Protein	B	1
FT	#SUB	134	 158 	VAL	B	160	 184 	PRO	A	Protein	S	1
FT	#SUB	136	 160 	GLN	B	160	 184 	PRO	A	Protein	S	2
FT	#SUB	139	 163 	ARG	B	163	 187 	LEU	A	Protein	S	1
FT	#SUB	149	 173 	ASP	B	23	  47 	LYS	A	Protein	A	4
FT	#SUB	149	 173 	ASP	B	24	  48 	ASP	A	Protein	S	7
FT	#SUB	151	 175 	ARG	B	23	  47 	LYS	A	Protein	S	1
FT	#SUB	151	 175 	ARG	B	25	  49 	ASP	A	Protein	S	2
FT	#SUB	151	 175 	ARG	B	31	  55 	THR	A	Protein	S	1
FT	#SUB	151	 175 	ARG	B	191	 215 	ARG	A	Protein	A	6
FT	#SUB	151	 175 	ARG	B	192	 216 	SER	A	Protein	S	1
FT	#SUB	151	 175 	ARG	B	230	 254 	ASP	A	Protein	S	2
FT	#SUB	151	 175 	ARG	B	232	 256 	HIS	A	Protein	S	9
FT	#SUB	151	 175 	ARG	B	234	 258 	TYR	A	Protein	S	3
FT	#SUB	152	 176 	ARG	B	26	  50 	ARG	A	Protein	S	2
FT	#SUB	152	 176 	ARG	B	158	 182 	TRP	A	Protein	A	2
FT	#SUB	152	 176 	ARG	B	169	 193 	PRO	A	Protein	S	5
FT	#SUB	152	 176 	ARG	B	191	 215 	ARG	A	Protein	S	5
FT	#SUB	154	 178 	ILE	B	158	 182 	TRP	A	Protein	S	9
FT	#SUB	154	 178 	ILE	B	191	 215 	ARG	A	Protein	S	2
FT	#SUB	156	 180 	CYS	B	158	 182 	TRP	A	Protein	S	1
FT	#SUB	158	 182 	TRP	B	152	 176 	ARG	A	Protein	S	1
FT	#SUB	158	 182 	TRP	B	154	 178 	ILE	A	Protein	S	5
FT	#SUB	158	 182 	TRP	B	156	 180 	CYS	A	Protein	S	1
FT	#SUB	159	 183 	ASN	B	118	 142 	PHE	A	Protein	S	1
FT	#SUB	160	 184 	PRO	B	118	 142 	PHE	A	Protein	S	5
FT	#SUB	160	 184 	PRO	B	134	 158 	VAL	A	Protein	B	1
FT	#SUB	160	 184 	PRO	B	136	 160 	GLN	A	Protein	S	2
FT	#SUB	163	 187 	LEU	B	139	 163 	ARG	A	Protein	S	1
FT	#SUB	169	 193 	PRO	B	152	 176 	ARG	A	Protein	S	2
FT	#SUB	173	 197 	ALA	B	174	 198 	LEU	A	Protein	S	1
FT	#SUB	174	 198 	LEU	B	173	 197 	ALA	A	Protein	S	1
FT	#SUB	174	 198 	LEU	B	189	 213 	TYR	A	Protein	S	1
FT	#SUB	176	 200 	GLN	B	35	  59 	PHE	A	Protein	A	3
FT	#SUB	176	 200 	GLN	B	189	 213 	TYR	A	Protein	S	5
FT	#SUB	176	 200 	GLN	B	191	 215 	ARG	A	Protein	S	10
FT	#SUB	176	 200 	GLN	B	229	 253 	GLY	A	Protein	S	1
FT	#SUB	178	 202 	TYR	B	23	  47 	LYS	A	Protein	S	6
FT	#SUB	178	 202 	TYR	B	33	  57 	SER	A	Protein	S	6
FT	#SUB	178	 202 	TYR	B	35	  59 	PHE	A	Protein	S	18
FT	#SUB	178	 202 	TYR	B	230	 254 	ASP	A	Protein	S	2
FT	#SUB	179	 203 	VAL	B	23	  47 	LYS	A	Protein	B	2
FT	#SUB	180	 204 	VAL	B	21	  45 	VAL	A	Protein	S	1
FT	#SUB	180	 204 	VAL	B	22	  46 	ARG	A	Protein	S	1
FT	#SUB	181	 205 	ASN	B	21	  45 	VAL	A	Protein	S	1
FT	#SUB	185	 209 	SER	B	35	  59 	PHE	A	Protein	S	1
FT	#SUB	186	 210 	CYS	B	35	  59 	PHE	A	Protein	B	2
FT	#SUB	187	 211 	GLN	B	35	  59 	PHE	A	Protein	A	4
FT	#SUB	187	 211 	GLN	B	36	  60 	GLY	A	Protein	S	1
FT	#SUB	187	 211 	GLN	B	189	 213 	TYR	A	Protein	S	8
FT	#SUB	187	 211 	GLN	B	227	 251 	THR	A	Protein	S	1
FT	#SUB	187	 211 	GLN	B	228	 252 	LEU	A	Protein	S	4
FT	#SUB	187	 211 	GLN	B	229	 253 	GLY	A	Protein	S	2
FT	#SUB	189	 213 	TYR	B	174	 198 	LEU	A	Protein	S	1
FT	#SUB	189	 213 	TYR	B	176	 200 	GLN	A	Protein	S	6
FT	#SUB	189	 213 	TYR	B	187	 211 	GLN	A	Protein	S	9
FT	#SUB	189	 213 	TYR	B	189	 213 	TYR	A	Protein	S	1
FT	#SUB	191	 215 	ARG	B	151	 175 	ARG	A	Protein	A	8
FT	#SUB	191	 215 	ARG	B	152	 176 	ARG	A	Protein	S	5
FT	#SUB	191	 215 	ARG	B	154	 178 	ILE	A	Protein	S	2
FT	#SUB	191	 215 	ARG	B	176	 200 	GLN	A	Protein	A	8
FT	#SUB	192	 216 	SER	B	151	 175 	ARG	A	Protein	S	2
FT	#SUB	225	 249 	ILE	B	35	  59 	PHE	A	Protein	S	2
FT	#SUB	227	 251 	THR	B	38	  62 	GLN	A	Protein	S	1
FT	#SUB	227	 251 	THR	B	187	 211 	GLN	A	Protein	S	1
FT	#SUB	227	 251 	THR	B	227	 251 	THR	A	Protein	S	3
FT	#SUB	228	 252 	LEU	B	187	 211 	GLN	A	Protein	B	3
FT	#SUB	229	 253 	GLY	B	176	 200 	GLN	A	Protein	B	1
FT	#SUB	229	 253 	GLY	B	187	 211 	GLN	A	Protein	B	2
FT	#SUB	230	 254 	ASP	B	151	 175 	ARG	A	Protein	S	6
FT	#SUB	230	 254 	ASP	B	178	 202 	TYR	A	Protein	S	4
FT	#SUB	232	 256 	HIS	B	151	 175 	ARG	A	Protein	S	8
FT	#SUB	234	 258 	TYR	B	151	 175 	ARG	A	Protein	S	2
FT	#SUB	92	 116 	ASP	B	54	  78 	ARG	C	Protein	A	2
FT	#SUB	92	 116 	ASP	B	282	 306 	THR	C	Protein	S	1
FT	#SUB	95	 119 	ASP	B	54	  78 	ARG	C	Protein	S	1
FT	#SUB	96	 120 	SER	B	54	  78 	ARG	C	Protein	A	7
FT	#SUB	101	 125 	THR	B	103	 127 	GLU	E	Protein	S	1
FT	#SUB	121	 145 	GLU	B	121	 145 	GLU	E	Protein	S	5
FT	#SUB	121	 145 	GLU	B	123	 147 	ARG	E	Protein	S	1
FT	#SUB	124	 148 	ASP	B	101	 125 	THR	E	Protein	S	4
FT	#HET	151	 175 	ARG	B	2	400 	DC	A	S	11
FT	#HET	152	 176 	ARG	B	2	400 	DC	A	S	6
FT	#HET	171	 195 	CYS	B	1	400 	DC	B	S	4
FT	#HET	172	 196 	HIS	B	1	400 	DC	B	S	2
FT	#HET	190	 214 	GLN	B	1	400 	DC	B	S	3
FT	#HET	191	 215 	ARG	B	1	400 	DC	B	S	7
FT	#HET	192	 216 	SER	B	1	400 	DC	B	A	6
FT	#HET	193	 217 	GLY	B	1	400 	DC	B	B	2
FT	#HET	194	 218 	ASP	B	1	400 	DC	B	A	7
FT	#HET	198	 222 	GLY	B	1	400 	DC	B	B	1
FT	#HET	202	 226 	ASN	B	1	400 	DC	B	S	8
FT	#HET	232	 256 	HIS	B	1	400 	DC	B	S	6
FT	#HET	234	 258 	TYR	B	1	400 	DC	B	S	3
FT	DISORDER	25	28
FT	DISORDER	287	289
CC	SEQUENCE	282 AA (ATOM);
CC	MPPHGELQYL GQIQHILRCG VRKDTGTLSV FGMQARYSLR DEFPLLTTKR VFWKGVLEEL
CC	LWFIKGSTNA KELSSKGVKI WDANGSRDFL DSLGFSTREE GDLGPVYGFQ WRHFGAEYRD
CC	MESDYSGQGV DQLQRVIDTI KTNPDDRRII MCAWNPRDLP LMALPPCHAL CQFYVVNSEL
CC	SCQLYQRSGD MGLGVPFNIA SYALLTYMIA HITGLKPGDF IHTLGDAHIY LNHIEPLKIQ
CC	LQREPRPFPK LRILRKVEKI DDFKAEDFQI EGYNPHPTIK ME
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLL
CC	ATOM   MPPHGELQYLGQIQHILRCGVRKD----TGTLSVFGMQARYSLRDEFPLL
CC	       ************************    **********************
CC	SEQRES TTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFS
CC	ATOM   TTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFS
CC	       **************************************************
CC	SEQRES TREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDD
CC	ATOM   TREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDD
CC	       **************************************************
CC	SEQRES RRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVP
CC	ATOM   RRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVP
CC	       **************************************************
CC	SEQRES FNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPR
CC	ATOM   FNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPR
CC	       **************************************************
CC	SEQRES PFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV
CC	ATOM   PFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKME---
CC	       ************************************   
SQ	SEQUENCE	289 AA;      MW;         CN;
	MPPHGELQYL GQIQHILRCG VRKDDRTGTG TLSVFGMQAR YSLRDEFPLL TTKRVFWKGV
	LEELLWFIKG STNAKELSSK GVKIWDANGS RDFLDSLGFS TREEGDLGPV YGFQWRHFGA
	EYRDMESDYS GQGVDQLQRV IDTIKTNPDD RRIIMCAWNP RDLPLMALPP CHALCQFYVV
	NSELSCQLYQ RSGDMGLGVP FNIASYALLT YMIAHITGLK PGDFIHTLGD AHIYLNHIEP
	LKIQLQREPR PFPKLRILRK VEKIDDFKAE DFQIEGYNPH PTIKMEMAV
//
ID	5WRNA	STANDARD;	PRT;	289	AA.
DT	CONVERTED FROM PDB (SEQRES) 5WRN
DE	Thymidylate synthase
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.390
CC	R-Factor	0.191
FT	#SUB	21	  45 	VAL	A	180	 204 	VAL	B	Protein	S	1
FT	#SUB	21	  45 	VAL	A	181	 205 	ASN	B	Protein	S	1
FT	#SUB	22	  46 	ARG	A	180	 204 	VAL	B	Protein	B	1
FT	#SUB	23	  47 	LYS	A	149	 173 	ASP	B	Protein	S	4
FT	#SUB	23	  47 	LYS	A	151	 175 	ARG	B	Protein	S	1
FT	#SUB	23	  47 	LYS	A	178	 202 	TYR	B	Protein	S	6
FT	#SUB	23	  47 	LYS	A	179	 203 	VAL	B	Protein	S	2
FT	#SUB	24	  48 	ASP	A	149	 173 	ASP	B	Protein	A	7
FT	#SUB	25	  49 	ASP	A	151	 175 	ARG	B	Protein	S	2
FT	#SUB	26	  50 	ARG	A	152	 176 	ARG	B	Protein	S	2
FT	#SUB	31	  55 	THR	A	151	 175 	ARG	B	Protein	S	1
FT	#SUB	33	  57 	SER	A	178	 202 	TYR	B	Protein	A	6
FT	#SUB	35	  59 	PHE	A	40	  64 	ARG	B	Protein	B	4
FT	#SUB	35	  59 	PHE	A	176	 200 	GLN	B	Protein	S	3
FT	#SUB	35	  59 	PHE	A	178	 202 	TYR	B	Protein	S	18
FT	#SUB	35	  59 	PHE	A	185	 209 	SER	B	Protein	S	1
FT	#SUB	35	  59 	PHE	A	186	 210 	CYS	B	Protein	S	2
FT	#SUB	35	  59 	PHE	A	187	 211 	GLN	B	Protein	S	4
FT	#SUB	35	  59 	PHE	A	225	 249 	ILE	B	Protein	A	2
FT	#SUB	36	  60 	GLY	A	38	  62 	GLN	B	Protein	B	2
FT	#SUB	36	  60 	GLY	A	40	  64 	ARG	B	Protein	B	3
FT	#SUB	36	  60 	GLY	A	187	 211 	GLN	B	Protein	B	1
FT	#SUB	37	  61 	MET	A	38	  62 	GLN	B	Protein	B	8
FT	#SUB	38	  62 	GLN	A	36	  60 	GLY	B	Protein	S	2
FT	#SUB	38	  62 	GLN	A	37	  61 	MET	B	Protein	S	10
FT	#SUB	38	  62 	GLN	A	38	  62 	GLN	B	Protein	A	8
FT	#SUB	38	  62 	GLN	A	227	 251 	THR	B	Protein	S	1
FT	#SUB	40	  64 	ARG	A	35	  59 	PHE	B	Protein	S	4
FT	#SUB	40	  64 	ARG	A	36	  60 	GLY	B	Protein	S	3
FT	#SUB	118	 142 	PHE	A	159	 183 	ASN	B	Protein	S	1
FT	#SUB	118	 142 	PHE	A	160	 184 	PRO	B	Protein	S	5
FT	#SUB	134	 158 	VAL	A	160	 184 	PRO	B	Protein	S	1
FT	#SUB	136	 160 	GLN	A	160	 184 	PRO	B	Protein	S	2
FT	#SUB	139	 163 	ARG	A	163	 187 	LEU	B	Protein	S	1
FT	#SUB	149	 173 	ASP	A	23	  47 	LYS	B	Protein	A	4
FT	#SUB	149	 173 	ASP	A	24	  48 	ASP	B	Protein	S	2
FT	#SUB	151	 175 	ARG	A	31	  55 	THR	B	Protein	S	1
FT	#SUB	151	 175 	ARG	A	191	 215 	ARG	B	Protein	A	8
FT	#SUB	151	 175 	ARG	A	192	 216 	SER	B	Protein	S	2
FT	#SUB	151	 175 	ARG	A	230	 254 	ASP	B	Protein	S	6
FT	#SUB	151	 175 	ARG	A	232	 256 	HIS	B	Protein	S	8
FT	#SUB	151	 175 	ARG	A	234	 258 	TYR	B	Protein	S	2
FT	#SUB	152	 176 	ARG	A	158	 182 	TRP	B	Protein	S	1
FT	#SUB	152	 176 	ARG	A	169	 193 	PRO	B	Protein	S	2
FT	#SUB	152	 176 	ARG	A	191	 215 	ARG	B	Protein	S	5
FT	#SUB	154	 178 	ILE	A	158	 182 	TRP	B	Protein	S	5
FT	#SUB	154	 178 	ILE	A	191	 215 	ARG	B	Protein	S	2
FT	#SUB	156	 180 	CYS	A	158	 182 	TRP	B	Protein	S	1
FT	#SUB	158	 182 	TRP	A	152	 176 	ARG	B	Protein	S	2
FT	#SUB	158	 182 	TRP	A	154	 178 	ILE	B	Protein	S	9
FT	#SUB	158	 182 	TRP	A	156	 180 	CYS	B	Protein	S	1
FT	#SUB	159	 183 	ASN	A	118	 142 	PHE	B	Protein	S	1
FT	#SUB	160	 184 	PRO	A	118	 142 	PHE	B	Protein	S	6
FT	#SUB	160	 184 	PRO	A	134	 158 	VAL	B	Protein	B	1
FT	#SUB	160	 184 	PRO	A	136	 160 	GLN	B	Protein	S	2
FT	#SUB	161	 185 	ARG	A	119	 143 	GLY	B	Protein	S	1
FT	#SUB	163	 187 	LEU	A	139	 163 	ARG	B	Protein	S	1
FT	#SUB	169	 193 	PRO	A	152	 176 	ARG	B	Protein	S	5
FT	#SUB	173	 197 	ALA	A	174	 198 	LEU	B	Protein	S	1
FT	#SUB	174	 198 	LEU	A	173	 197 	ALA	B	Protein	S	1
FT	#SUB	174	 198 	LEU	A	189	 213 	TYR	B	Protein	S	1
FT	#SUB	176	 200 	GLN	A	35	  59 	PHE	B	Protein	A	2
FT	#SUB	176	 200 	GLN	A	189	 213 	TYR	B	Protein	S	6
FT	#SUB	176	 200 	GLN	A	191	 215 	ARG	B	Protein	S	8
FT	#SUB	176	 200 	GLN	A	229	 253 	GLY	B	Protein	S	1
FT	#SUB	178	 202 	TYR	A	23	  47 	LYS	B	Protein	S	7
FT	#SUB	178	 202 	TYR	A	33	  57 	SER	B	Protein	S	6
FT	#SUB	178	 202 	TYR	A	35	  59 	PHE	B	Protein	S	15
FT	#SUB	178	 202 	TYR	A	230	 254 	ASP	B	Protein	S	4
FT	#SUB	179	 203 	VAL	A	23	  47 	LYS	B	Protein	B	2
FT	#SUB	180	 204 	VAL	A	21	  45 	VAL	B	Protein	S	1
FT	#SUB	181	 205 	ASN	A	21	  45 	VAL	B	Protein	S	1
FT	#SUB	185	 209 	SER	A	35	  59 	PHE	B	Protein	S	1
FT	#SUB	186	 210 	CYS	A	35	  59 	PHE	B	Protein	B	2
FT	#SUB	187	 211 	GLN	A	35	  59 	PHE	B	Protein	A	3
FT	#SUB	187	 211 	GLN	A	36	  60 	GLY	B	Protein	S	1
FT	#SUB	187	 211 	GLN	A	189	 213 	TYR	B	Protein	S	9
FT	#SUB	187	 211 	GLN	A	227	 251 	THR	B	Protein	S	1
FT	#SUB	187	 211 	GLN	A	228	 252 	LEU	B	Protein	S	3
FT	#SUB	187	 211 	GLN	A	229	 253 	GLY	B	Protein	S	2
FT	#SUB	189	 213 	TYR	A	174	 198 	LEU	B	Protein	S	1
FT	#SUB	189	 213 	TYR	A	176	 200 	GLN	B	Protein	S	5
FT	#SUB	189	 213 	TYR	A	187	 211 	GLN	B	Protein	S	8
FT	#SUB	189	 213 	TYR	A	189	 213 	TYR	B	Protein	S	1
FT	#SUB	191	 215 	ARG	A	151	 175 	ARG	B	Protein	S	6
FT	#SUB	191	 215 	ARG	A	152	 176 	ARG	B	Protein	S	5
FT	#SUB	191	 215 	ARG	A	154	 178 	ILE	B	Protein	S	2
FT	#SUB	191	 215 	ARG	A	176	 200 	GLN	B	Protein	A	10
FT	#SUB	192	 216 	SER	A	151	 175 	ARG	B	Protein	S	1
FT	#SUB	225	 249 	ILE	A	35	  59 	PHE	B	Protein	S	4
FT	#SUB	227	 251 	THR	A	38	  62 	GLN	B	Protein	S	1
FT	#SUB	227	 251 	THR	A	187	 211 	GLN	B	Protein	S	1
FT	#SUB	227	 251 	THR	A	227	 251 	THR	B	Protein	S	3
FT	#SUB	228	 252 	LEU	A	187	 211 	GLN	B	Protein	B	4
FT	#SUB	229	 253 	GLY	A	176	 200 	GLN	B	Protein	B	1
FT	#SUB	229	 253 	GLY	A	187	 211 	GLN	B	Protein	B	2
FT	#SUB	230	 254 	ASP	A	151	 175 	ARG	B	Protein	S	2
FT	#SUB	230	 254 	ASP	A	178	 202 	TYR	B	Protein	S	2
FT	#SUB	232	 256 	HIS	A	151	 175 	ARG	B	Protein	S	9
FT	#SUB	234	 258 	TYR	A	151	 175 	ARG	B	Protein	S	3
FT	#SUB	101	 125 	THR	A	124	 148 	ASP	F	Protein	S	4
FT	#SUB	103	 127 	GLU	A	101	 125 	THR	F	Protein	S	1
FT	#SUB	121	 145 	GLU	A	121	 145 	GLU	F	Protein	S	3
FT	#HET	26	  50 	ARG	A	2	400 	DC	A	S	4
FT	#HET	151	 175 	ARG	A	1	400 	DC	B	S	7
FT	#HET	152	 176 	ARG	A	1	400 	DC	B	S	8
FT	#HET	171	 195 	CYS	A	2	400 	DC	A	S	7
FT	#HET	172	 196 	HIS	A	2	400 	DC	A	S	2
FT	#HET	190	 214 	GLN	A	2	400 	DC	A	S	3
FT	#HET	191	 215 	ARG	A	2	400 	DC	A	S	8
FT	#HET	192	 216 	SER	A	2	400 	DC	A	A	5
FT	#HET	193	 217 	GLY	A	2	400 	DC	A	B	2
FT	#HET	194	 218 	ASP	A	2	400 	DC	A	A	6
FT	#HET	198	 222 	GLY	A	2	400 	DC	A	B	1
FT	#HET	202	 226 	ASN	A	2	400 	DC	A	S	7
FT	#HET	232	 256 	HIS	A	2	400 	DC	A	S	6
FT	#HET	234	 258 	TYR	A	2	400 	DC	A	S	3
FT	DISORDER	285	289
CC	SEQUENCE	284 AA (ATOM);
CC	MPPHGELQYL GQIQHILRCG VRKDDRTGTG TLSVFGMQAR YSLRDEFPLL TTKRVFWKGV
CC	LEELLWFIKG STNAKELSSK GVKIWDANGS RDFLDSLGFS TREEGDLGPV YGFQWRHFGA
CC	EYRDMESDYS GQGVDQLQRV IDTIKTNPDD RRIIMCAWNP RDLPLMALPP CHALCQFYVV
CC	NSELSCQLYQ RSGDMGLGVP FNIASYALLT YMIAHITGLK PGDFIHTLGD AHIYLNHIEP
CC	LKIQLQREPR PFPKLRILRK VEKIDDFKAE DFQIEGYNPH PTIK
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLL
CC	ATOM   MPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLL
CC	       **************************************************
CC	SEQRES TTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFS
CC	ATOM   TTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFS
CC	       **************************************************
CC	SEQRES TREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDD
CC	ATOM   TREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDD
CC	       **************************************************
CC	SEQRES RRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVP
CC	ATOM   RRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVP
CC	       **************************************************
CC	SEQRES FNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPR
CC	ATOM   FNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPR
CC	       **************************************************
CC	SEQRES PFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV
CC	ATOM   PFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIK-----
CC	       **********************************     
SQ	SEQUENCE	289 AA;      MW;         CN;
	MPPHGELQYL GQIQHILRCG VRKDDRTGTG TLSVFGMQAR YSLRDEFPLL TTKRVFWKGV
	LEELLWFIKG STNAKELSSK GVKIWDANGS RDFLDSLGFS TREEGDLGPV YGFQWRHFGA
	EYRDMESDYS GQGVDQLQRV IDTIKTNPDD RRIIMCAWNP RDLPLMALPP CHALCQFYVV
	NSELSCQLYQ RSGDMGLGVP FNIASYALLT YMIAHITGLK PGDFIHTLGD AHIYLNHIEP
	LKIQLQREPR PFPKLRILRK VEKIDDFKAE DFQIEGYNPH PTIKMEMAV
//
ID	5WRNC	STANDARD;	PRT;	289	AA.
DT	CONVERTED FROM PDB (SEQRES) 5WRN
DE	Thymidylate synthase
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.390
CC	R-Factor	0.191
FT	#SUB	54	  78 	ARG	C	92	 116 	ASP	B	Protein	S	2
FT	#SUB	54	  78 	ARG	C	95	 119 	ASP	B	Protein	S	1
FT	#SUB	54	  78 	ARG	C	96	 120 	SER	B	Protein	S	7
FT	#SUB	282	 306 	THR	C	92	 116 	ASP	B	Protein	S	1
FT	#SUB	21	  45 	VAL	C	180	 204 	VAL	D	Protein	S	1
FT	#SUB	21	  45 	VAL	C	181	 205 	ASN	D	Protein	S	1
FT	#SUB	22	  46 	ARG	C	180	 204 	VAL	D	Protein	B	1
FT	#SUB	23	  47 	LYS	C	149	 173 	ASP	D	Protein	S	3
FT	#SUB	23	  47 	LYS	C	178	 202 	TYR	D	Protein	S	8
FT	#SUB	23	  47 	LYS	C	179	 203 	VAL	D	Protein	S	2
FT	#SUB	23	  47 	LYS	C	180	 204 	VAL	D	Protein	S	1
FT	#SUB	24	  48 	ASP	C	149	 173 	ASP	D	Protein	A	8
FT	#SUB	25	  49 	ASP	C	151	 175 	ARG	D	Protein	S	6
FT	#SUB	26	  50 	ARG	C	151	 175 	ARG	D	Protein	S	1
FT	#SUB	26	  50 	ARG	C	152	 176 	ARG	D	Protein	S	2
FT	#SUB	33	  57 	SER	C	178	 202 	TYR	D	Protein	A	6
FT	#SUB	35	  59 	PHE	C	40	  64 	ARG	D	Protein	B	4
FT	#SUB	35	  59 	PHE	C	176	 200 	GLN	D	Protein	S	5
FT	#SUB	35	  59 	PHE	C	178	 202 	TYR	D	Protein	S	16
FT	#SUB	35	  59 	PHE	C	185	 209 	SER	D	Protein	S	1
FT	#SUB	35	  59 	PHE	C	186	 210 	CYS	D	Protein	S	1
FT	#SUB	35	  59 	PHE	C	187	 211 	GLN	D	Protein	S	4
FT	#SUB	35	  59 	PHE	C	225	 249 	ILE	D	Protein	A	4
FT	#SUB	36	  60 	GLY	C	38	  62 	GLN	D	Protein	B	2
FT	#SUB	36	  60 	GLY	C	40	  64 	ARG	D	Protein	B	3
FT	#SUB	36	  60 	GLY	C	187	 211 	GLN	D	Protein	B	1
FT	#SUB	37	  61 	MET	C	38	  62 	GLN	D	Protein	B	9
FT	#SUB	38	  62 	GLN	C	36	  60 	GLY	D	Protein	S	2
FT	#SUB	38	  62 	GLN	C	37	  61 	MET	D	Protein	S	8
FT	#SUB	38	  62 	GLN	C	38	  62 	GLN	D	Protein	A	8
FT	#SUB	38	  62 	GLN	C	227	 251 	THR	D	Protein	S	1
FT	#SUB	40	  64 	ARG	C	35	  59 	PHE	D	Protein	S	4
FT	#SUB	40	  64 	ARG	C	36	  60 	GLY	D	Protein	S	4
FT	#SUB	118	 142 	PHE	C	159	 183 	ASN	D	Protein	S	1
FT	#SUB	118	 142 	PHE	C	160	 184 	PRO	D	Protein	S	5
FT	#SUB	134	 158 	VAL	C	160	 184 	PRO	D	Protein	S	1
FT	#SUB	136	 160 	GLN	C	160	 184 	PRO	D	Protein	S	2
FT	#SUB	149	 173 	ASP	C	23	  47 	LYS	D	Protein	A	8
FT	#SUB	151	 175 	ARG	C	31	  55 	THR	D	Protein	S	1
FT	#SUB	151	 175 	ARG	C	191	 215 	ARG	D	Protein	A	7
FT	#SUB	151	 175 	ARG	C	192	 216 	SER	D	Protein	S	1
FT	#SUB	151	 175 	ARG	C	230	 254 	ASP	D	Protein	S	2
FT	#SUB	151	 175 	ARG	C	232	 256 	HIS	D	Protein	S	6
FT	#SUB	151	 175 	ARG	C	234	 258 	TYR	D	Protein	S	1
FT	#SUB	152	 176 	ARG	C	158	 182 	TRP	D	Protein	A	3
FT	#SUB	152	 176 	ARG	C	169	 193 	PRO	D	Protein	S	3
FT	#SUB	152	 176 	ARG	C	191	 215 	ARG	D	Protein	S	2
FT	#SUB	154	 178 	ILE	C	158	 182 	TRP	D	Protein	S	10
FT	#SUB	154	 178 	ILE	C	191	 215 	ARG	D	Protein	S	2
FT	#SUB	156	 180 	CYS	C	158	 182 	TRP	D	Protein	S	1
FT	#SUB	158	 182 	TRP	C	152	 176 	ARG	D	Protein	S	3
FT	#SUB	158	 182 	TRP	C	154	 178 	ILE	D	Protein	S	6
FT	#SUB	158	 182 	TRP	C	156	 180 	CYS	D	Protein	S	1
FT	#SUB	159	 183 	ASN	C	118	 142 	PHE	D	Protein	S	1
FT	#SUB	160	 184 	PRO	C	118	 142 	PHE	D	Protein	S	5
FT	#SUB	160	 184 	PRO	C	134	 158 	VAL	D	Protein	B	2
FT	#SUB	160	 184 	PRO	C	136	 160 	GLN	D	Protein	S	2
FT	#SUB	161	 185 	ARG	C	119	 143 	GLY	D	Protein	S	1
FT	#SUB	169	 193 	PRO	C	152	 176 	ARG	D	Protein	S	5
FT	#SUB	173	 197 	ALA	C	174	 198 	LEU	D	Protein	S	1
FT	#SUB	174	 198 	LEU	C	173	 197 	ALA	D	Protein	S	1
FT	#SUB	176	 200 	GLN	C	35	  59 	PHE	D	Protein	A	3
FT	#SUB	176	 200 	GLN	C	189	 213 	TYR	D	Protein	S	5
FT	#SUB	176	 200 	GLN	C	191	 215 	ARG	D	Protein	S	10
FT	#SUB	176	 200 	GLN	C	229	 253 	GLY	D	Protein	S	1
FT	#SUB	178	 202 	TYR	C	23	  47 	LYS	D	Protein	S	3
FT	#SUB	178	 202 	TYR	C	33	  57 	SER	D	Protein	S	6
FT	#SUB	178	 202 	TYR	C	35	  59 	PHE	D	Protein	S	17
FT	#SUB	178	 202 	TYR	C	230	 254 	ASP	D	Protein	S	3
FT	#SUB	179	 203 	VAL	C	23	  47 	LYS	D	Protein	B	2
FT	#SUB	180	 204 	VAL	C	21	  45 	VAL	D	Protein	S	1
FT	#SUB	181	 205 	ASN	C	21	  45 	VAL	D	Protein	S	1
FT	#SUB	185	 209 	SER	C	35	  59 	PHE	D	Protein	S	1
FT	#SUB	186	 210 	CYS	C	35	  59 	PHE	D	Protein	B	1
FT	#SUB	187	 211 	GLN	C	35	  59 	PHE	D	Protein	A	4
FT	#SUB	187	 211 	GLN	C	36	  60 	GLY	D	Protein	S	1
FT	#SUB	187	 211 	GLN	C	189	 213 	TYR	D	Protein	S	9
FT	#SUB	187	 211 	GLN	C	227	 251 	THR	D	Protein	S	1
FT	#SUB	187	 211 	GLN	C	228	 252 	LEU	D	Protein	S	4
FT	#SUB	187	 211 	GLN	C	229	 253 	GLY	D	Protein	S	2
FT	#SUB	189	 213 	TYR	C	174	 198 	LEU	D	Protein	S	1
FT	#SUB	189	 213 	TYR	C	176	 200 	GLN	D	Protein	S	5
FT	#SUB	189	 213 	TYR	C	187	 211 	GLN	D	Protein	S	8
FT	#SUB	189	 213 	TYR	C	189	 213 	TYR	D	Protein	S	1
FT	#SUB	191	 215 	ARG	C	151	 175 	ARG	D	Protein	A	7
FT	#SUB	191	 215 	ARG	C	152	 176 	ARG	D	Protein	S	3
FT	#SUB	191	 215 	ARG	C	154	 178 	ILE	D	Protein	S	2
FT	#SUB	191	 215 	ARG	C	176	 200 	GLN	D	Protein	A	9
FT	#SUB	192	 216 	SER	C	151	 175 	ARG	D	Protein	S	2
FT	#SUB	225	 249 	ILE	C	35	  59 	PHE	D	Protein	S	3
FT	#SUB	227	 251 	THR	C	38	  62 	GLN	D	Protein	S	1
FT	#SUB	227	 251 	THR	C	187	 211 	GLN	D	Protein	S	1
FT	#SUB	227	 251 	THR	C	227	 251 	THR	D	Protein	S	3
FT	#SUB	228	 252 	LEU	C	187	 211 	GLN	D	Protein	B	4
FT	#SUB	229	 253 	GLY	C	176	 200 	GLN	D	Protein	B	1
FT	#SUB	229	 253 	GLY	C	187	 211 	GLN	D	Protein	B	2
FT	#SUB	230	 254 	ASP	C	151	 175 	ARG	D	Protein	S	5
FT	#SUB	230	 254 	ASP	C	178	 202 	TYR	D	Protein	S	3
FT	#SUB	232	 256 	HIS	C	151	 175 	ARG	D	Protein	S	3
FT	#SUB	234	 258 	TYR	C	151	 175 	ARG	D	Protein	S	3
FT	#SUB	58	  82 	LYS	C	126	 150 	GLU	E	Protein	S	1
FT	#SUB	73	  97 	ASN	C	79	 103 	SER	E	Protein	S	3
FT	#SUB	75	  99 	LYS	C	79	 103 	SER	E	Protein	A	4
FT	#SUB	76	 100 	GLU	C	79	 103 	SER	E	Protein	A	4
FT	#SUB	76	 100 	GLU	C	80	 104 	LYS	E	Protein	S	5
FT	#SUB	78	 102 	SER	C	75	  99 	LYS	E	Protein	B	2
FT	#SUB	79	 103 	SER	C	73	  97 	ASN	E	Protein	B	2
FT	#SUB	79	 103 	SER	C	75	  99 	LYS	E	Protein	A	2
FT	#SUB	79	 103 	SER	C	76	 100 	GLU	E	Protein	S	4
FT	#SUB	83	 107 	LYS	C	75	  99 	LYS	E	Protein	S	1
FT	#SUB	126	 150 	GLU	C	58	  82 	LYS	E	Protein	S	1
FT	#SUB	126	 150 	GLU	C	79	 103 	SER	E	Protein	S	1
FT	#SUB	126	 150 	GLU	C	80	 104 	LYS	E	Protein	S	2
FT	#SUB	126	 150 	GLU	C	81	 105 	GLY	E	Protein	S	1
FT	#SUB	128	 152 	ASP	C	270	 294 	GLU	E	Protein	S	2
FT	#SUB	270	 294 	GLU	C	128	 152 	ASP	E	Protein	S	2
FT	#HET	26	  50 	ARG	C	3	400 	DC	C	S	11
FT	#HET	151	 175 	ARG	C	4	400 	DC	D	S	11
FT	#HET	152	 176 	ARG	C	4	400 	DC	D	S	5
FT	#HET	171	 195 	CYS	C	3	400 	DC	C	S	3
FT	#HET	172	 196 	HIS	C	3	400 	DC	C	S	2
FT	#HET	190	 214 	GLN	C	3	400 	DC	C	S	2
FT	#HET	191	 215 	ARG	C	3	400 	DC	C	S	8
FT	#HET	192	 216 	SER	C	3	400 	DC	C	A	6
FT	#HET	193	 217 	GLY	C	3	400 	DC	C	B	2
FT	#HET	194	 218 	ASP	C	3	400 	DC	C	A	8
FT	#HET	198	 222 	GLY	C	3	400 	DC	C	B	2
FT	#HET	202	 226 	ASN	C	3	400 	DC	C	S	9
FT	#HET	232	 256 	HIS	C	3	400 	DC	C	S	7
FT	#HET	234	 258 	TYR	C	3	400 	DC	C	S	4
FT	DISORDER	283	289
CC	SEQUENCE	282 AA (ATOM);
CC	MPPHGELQYL GQIQHILRCG VRKDDRTGTG TLSVFGMQAR YSLRDEFPLL TTKRVFWKGV
CC	LEELLWFIKG STNAKELSSK GVKIWDANGS RDFLDSLGFS TREEGDLGPV YGFQWRHFGA
CC	EYRDMESDYS GQGVDQLQRV IDTIKTNPDD RRIIMCAWNP RDLPLMALPP CHALCQFYVV
CC	NSELSCQLYQ RSGDMGLGVP FNIASYALLT YMIAHITGLK PGDFIHTLGD AHIYLNHIEP
CC	LKIQLQREPR PFPKLRILRK VEKIDDFKAE DFQIEGYNPH PT
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLL
CC	ATOM   MPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLL
CC	       **************************************************
CC	SEQRES TTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFS
CC	ATOM   TTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFS
CC	       **************************************************
CC	SEQRES TREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDD
CC	ATOM   TREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDD
CC	       **************************************************
CC	SEQRES RRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVP
CC	ATOM   RRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVP
CC	       **************************************************
CC	SEQRES FNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPR
CC	ATOM   FNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPR
CC	       **************************************************
CC	SEQRES PFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV
CC	ATOM   PFPKLRILRKVEKIDDFKAEDFQIEGYNPHPT-------
CC	       ********************************       
SQ	SEQUENCE	289 AA;      MW;         CN;
	MPPHGELQYL GQIQHILRCG VRKDDRTGTG TLSVFGMQAR YSLRDEFPLL TTKRVFWKGV
	LEELLWFIKG STNAKELSSK GVKIWDANGS RDFLDSLGFS TREEGDLGPV YGFQWRHFGA
	EYRDMESDYS GQGVDQLQRV IDTIKTNPDD RRIIMCAWNP RDLPLMALPP CHALCQFYVV
	NSELSCQLYQ RSGDMGLGVP FNIASYALLT YMIAHITGLK PGDFIHTLGD AHIYLNHIEP
	LKIQLQREPR PFPKLRILRK VEKIDDFKAE DFQIEGYNPH PTIKMEMAV
//
ID	5WRND	STANDARD;	PRT;	289	AA.
DT	CONVERTED FROM PDB (SEQRES) 5WRN
DE	Thymidylate synthase
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.390
CC	R-Factor	0.191
FT	#SUB	21	  45 	VAL	D	180	 204 	VAL	C	Protein	S	1
FT	#SUB	21	  45 	VAL	D	181	 205 	ASN	C	Protein	S	1
FT	#SUB	23	  47 	LYS	D	149	 173 	ASP	C	Protein	A	8
FT	#SUB	23	  47 	LYS	D	178	 202 	TYR	C	Protein	S	3
FT	#SUB	23	  47 	LYS	D	179	 203 	VAL	C	Protein	S	2
FT	#SUB	31	  55 	THR	D	151	 175 	ARG	C	Protein	S	1
FT	#SUB	33	  57 	SER	D	178	 202 	TYR	C	Protein	A	6
FT	#SUB	35	  59 	PHE	D	40	  64 	ARG	C	Protein	B	4
FT	#SUB	35	  59 	PHE	D	176	 200 	GLN	C	Protein	S	3
FT	#SUB	35	  59 	PHE	D	178	 202 	TYR	C	Protein	S	17
FT	#SUB	35	  59 	PHE	D	185	 209 	SER	C	Protein	S	1
FT	#SUB	35	  59 	PHE	D	186	 210 	CYS	C	Protein	S	1
FT	#SUB	35	  59 	PHE	D	187	 211 	GLN	C	Protein	S	4
FT	#SUB	35	  59 	PHE	D	225	 249 	ILE	C	Protein	A	3
FT	#SUB	36	  60 	GLY	D	38	  62 	GLN	C	Protein	B	2
FT	#SUB	36	  60 	GLY	D	40	  64 	ARG	C	Protein	B	4
FT	#SUB	36	  60 	GLY	D	187	 211 	GLN	C	Protein	B	1
FT	#SUB	37	  61 	MET	D	38	  62 	GLN	C	Protein	B	8
FT	#SUB	38	  62 	GLN	D	36	  60 	GLY	C	Protein	S	2
FT	#SUB	38	  62 	GLN	D	37	  61 	MET	C	Protein	S	9
FT	#SUB	38	  62 	GLN	D	38	  62 	GLN	C	Protein	A	8
FT	#SUB	38	  62 	GLN	D	227	 251 	THR	C	Protein	S	1
FT	#SUB	40	  64 	ARG	D	35	  59 	PHE	C	Protein	S	4
FT	#SUB	40	  64 	ARG	D	36	  60 	GLY	C	Protein	S	3
FT	#SUB	118	 142 	PHE	D	159	 183 	ASN	C	Protein	S	1
FT	#SUB	118	 142 	PHE	D	160	 184 	PRO	C	Protein	S	5
FT	#SUB	119	 143 	GLY	D	161	 185 	ARG	C	Protein	B	1
FT	#SUB	134	 158 	VAL	D	160	 184 	PRO	C	Protein	S	2
FT	#SUB	136	 160 	GLN	D	160	 184 	PRO	C	Protein	S	2
FT	#SUB	149	 173 	ASP	D	23	  47 	LYS	C	Protein	A	3
FT	#SUB	149	 173 	ASP	D	24	  48 	ASP	C	Protein	S	8
FT	#SUB	151	 175 	ARG	D	25	  49 	ASP	C	Protein	S	6
FT	#SUB	151	 175 	ARG	D	26	  50 	ARG	C	Protein	S	1
FT	#SUB	151	 175 	ARG	D	191	 215 	ARG	C	Protein	A	7
FT	#SUB	151	 175 	ARG	D	192	 216 	SER	C	Protein	S	2
FT	#SUB	151	 175 	ARG	D	230	 254 	ASP	C	Protein	S	5
FT	#SUB	151	 175 	ARG	D	232	 256 	HIS	C	Protein	S	3
FT	#SUB	151	 175 	ARG	D	234	 258 	TYR	C	Protein	S	3
FT	#SUB	152	 176 	ARG	D	26	  50 	ARG	C	Protein	S	2
FT	#SUB	152	 176 	ARG	D	158	 182 	TRP	C	Protein	A	3
FT	#SUB	152	 176 	ARG	D	169	 193 	PRO	C	Protein	S	5
FT	#SUB	152	 176 	ARG	D	191	 215 	ARG	C	Protein	S	3
FT	#SUB	154	 178 	ILE	D	158	 182 	TRP	C	Protein	S	6
FT	#SUB	154	 178 	ILE	D	191	 215 	ARG	C	Protein	S	2
FT	#SUB	156	 180 	CYS	D	158	 182 	TRP	C	Protein	S	1
FT	#SUB	158	 182 	TRP	D	152	 176 	ARG	C	Protein	S	3
FT	#SUB	158	 182 	TRP	D	154	 178 	ILE	C	Protein	S	10
FT	#SUB	158	 182 	TRP	D	156	 180 	CYS	C	Protein	S	1
FT	#SUB	159	 183 	ASN	D	118	 142 	PHE	C	Protein	S	1
FT	#SUB	160	 184 	PRO	D	118	 142 	PHE	C	Protein	S	5
FT	#SUB	160	 184 	PRO	D	134	 158 	VAL	C	Protein	B	1
FT	#SUB	160	 184 	PRO	D	136	 160 	GLN	C	Protein	S	2
FT	#SUB	169	 193 	PRO	D	152	 176 	ARG	C	Protein	S	3
FT	#SUB	173	 197 	ALA	D	174	 198 	LEU	C	Protein	S	1
FT	#SUB	174	 198 	LEU	D	173	 197 	ALA	C	Protein	S	1
FT	#SUB	174	 198 	LEU	D	189	 213 	TYR	C	Protein	S	1
FT	#SUB	176	 200 	GLN	D	35	  59 	PHE	C	Protein	A	5
FT	#SUB	176	 200 	GLN	D	189	 213 	TYR	C	Protein	S	5
FT	#SUB	176	 200 	GLN	D	191	 215 	ARG	C	Protein	S	9
FT	#SUB	176	 200 	GLN	D	229	 253 	GLY	C	Protein	S	1
FT	#SUB	178	 202 	TYR	D	23	  47 	LYS	C	Protein	S	8
FT	#SUB	178	 202 	TYR	D	33	  57 	SER	C	Protein	S	6
FT	#SUB	178	 202 	TYR	D	35	  59 	PHE	C	Protein	S	16
FT	#SUB	178	 202 	TYR	D	230	 254 	ASP	C	Protein	S	3
FT	#SUB	179	 203 	VAL	D	23	  47 	LYS	C	Protein	B	2
FT	#SUB	180	 204 	VAL	D	21	  45 	VAL	C	Protein	S	1
FT	#SUB	180	 204 	VAL	D	22	  46 	ARG	C	Protein	S	1
FT	#SUB	180	 204 	VAL	D	23	  47 	LYS	C	Protein	S	1
FT	#SUB	181	 205 	ASN	D	21	  45 	VAL	C	Protein	S	1
FT	#SUB	185	 209 	SER	D	35	  59 	PHE	C	Protein	S	1
FT	#SUB	186	 210 	CYS	D	35	  59 	PHE	C	Protein	B	1
FT	#SUB	187	 211 	GLN	D	35	  59 	PHE	C	Protein	A	4
FT	#SUB	187	 211 	GLN	D	36	  60 	GLY	C	Protein	S	1
FT	#SUB	187	 211 	GLN	D	189	 213 	TYR	C	Protein	S	8
FT	#SUB	187	 211 	GLN	D	227	 251 	THR	C	Protein	S	1
FT	#SUB	187	 211 	GLN	D	228	 252 	LEU	C	Protein	S	4
FT	#SUB	187	 211 	GLN	D	229	 253 	GLY	C	Protein	S	2
FT	#SUB	189	 213 	TYR	D	176	 200 	GLN	C	Protein	S	5
FT	#SUB	189	 213 	TYR	D	187	 211 	GLN	C	Protein	S	9
FT	#SUB	189	 213 	TYR	D	189	 213 	TYR	C	Protein	S	1
FT	#SUB	191	 215 	ARG	D	151	 175 	ARG	C	Protein	S	7
FT	#SUB	191	 215 	ARG	D	152	 176 	ARG	C	Protein	S	2
FT	#SUB	191	 215 	ARG	D	154	 178 	ILE	C	Protein	S	2
FT	#SUB	191	 215 	ARG	D	176	 200 	GLN	C	Protein	A	10
FT	#SUB	192	 216 	SER	D	151	 175 	ARG	C	Protein	S	1
FT	#SUB	225	 249 	ILE	D	35	  59 	PHE	C	Protein	S	4
FT	#SUB	227	 251 	THR	D	38	  62 	GLN	C	Protein	S	1
FT	#SUB	227	 251 	THR	D	187	 211 	GLN	C	Protein	S	1
FT	#SUB	227	 251 	THR	D	227	 251 	THR	C	Protein	S	3
FT	#SUB	228	 252 	LEU	D	187	 211 	GLN	C	Protein	B	4
FT	#SUB	229	 253 	GLY	D	176	 200 	GLN	C	Protein	B	1
FT	#SUB	229	 253 	GLY	D	187	 211 	GLN	C	Protein	B	2
FT	#SUB	230	 254 	ASP	D	151	 175 	ARG	C	Protein	S	2
FT	#SUB	230	 254 	ASP	D	178	 202 	TYR	C	Protein	S	3
FT	#SUB	232	 256 	HIS	D	151	 175 	ARG	C	Protein	S	6
FT	#SUB	234	 258 	TYR	D	151	 175 	ARG	C	Protein	S	1
FT	#HET	151	 175 	ARG	D	3	400 	DC	C	S	14
FT	#HET	152	 176 	ARG	D	3	400 	DC	C	S	6
FT	#HET	171	 195 	CYS	D	4	400 	DC	D	S	5
FT	#HET	172	 196 	HIS	D	4	400 	DC	D	S	2
FT	#HET	190	 214 	GLN	D	4	400 	DC	D	S	3
FT	#HET	191	 215 	ARG	D	4	400 	DC	D	S	8
FT	#HET	192	 216 	SER	D	4	400 	DC	D	A	7
FT	#HET	193	 217 	GLY	D	4	400 	DC	D	B	2
FT	#HET	194	 218 	ASP	D	4	400 	DC	D	A	7
FT	#HET	198	 222 	GLY	D	4	400 	DC	D	B	1
FT	#HET	202	 226 	ASN	D	4	400 	DC	D	S	9
FT	#HET	232	 256 	HIS	D	4	400 	DC	D	S	7
FT	#HET	234	 258 	TYR	D	4	400 	DC	D	S	5
FT	DISORDER	287	289
CC	SEQUENCE	286 AA (ATOM);
CC	MPPHGELQYL GQIQHILRCG VRKDDRTGTG TLSVFGMQAR YSLRDEFPLL TTKRVFWKGV
CC	LEELLWFIKG STNAKELSSK GVKIWDANGS RDFLDSLGFS TREEGDLGPV YGFQWRHFGA
CC	EYRDMESDYS GQGVDQLQRV IDTIKTNPDD RRIIMCAWNP RDLPLMALPP CHALCQFYVV
CC	NSELSCQLYQ RSGDMGLGVP FNIASYALLT YMIAHITGLK PGDFIHTLGD AHIYLNHIEP
CC	LKIQLQREPR PFPKLRILRK VEKIDDFKAE DFQIEGYNPH PTIKME
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLL
CC	ATOM   MPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLL
CC	       **************************************************
CC	SEQRES TTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFS
CC	ATOM   TTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFS
CC	       **************************************************
CC	SEQRES TREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDD
CC	ATOM   TREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDD
CC	       **************************************************
CC	SEQRES RRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVP
CC	ATOM   RRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVP
CC	       **************************************************
CC	SEQRES FNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPR
CC	ATOM   FNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPR
CC	       **************************************************
CC	SEQRES PFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV
CC	ATOM   PFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKME---
CC	       ************************************   
SQ	SEQUENCE	289 AA;      MW;         CN;
	MPPHGELQYL GQIQHILRCG VRKDDRTGTG TLSVFGMQAR YSLRDEFPLL TTKRVFWKGV
	LEELLWFIKG STNAKELSSK GVKIWDANGS RDFLDSLGFS TREEGDLGPV YGFQWRHFGA
	EYRDMESDYS GQGVDQLQRV IDTIKTNPDD RRIIMCAWNP RDLPLMALPP CHALCQFYVV
	NSELSCQLYQ RSGDMGLGVP FNIASYALLT YMIAHITGLK PGDFIHTLGD AHIYLNHIEP
	LKIQLQREPR PFPKLRILRK VEKIDDFKAE DFQIEGYNPH PTIKMEMAV
//
ID	5WRNE	STANDARD;	PRT;	289	AA.
DT	CONVERTED FROM PDB (SEQRES) 5WRN
DE	Thymidylate synthase
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.390
CC	R-Factor	0.191
FT	#SUB	101	 125 	THR	E	124	 148 	ASP	B	Protein	S	4
FT	#SUB	103	 127 	GLU	E	101	 125 	THR	B	Protein	S	1
FT	#SUB	121	 145 	GLU	E	121	 145 	GLU	B	Protein	S	5
FT	#SUB	123	 147 	ARG	E	121	 145 	GLU	B	Protein	S	1
FT	#SUB	58	  82 	LYS	E	126	 150 	GLU	C	Protein	S	1
FT	#SUB	73	  97 	ASN	E	79	 103 	SER	C	Protein	S	2
FT	#SUB	75	  99 	LYS	E	78	 102 	SER	C	Protein	S	2
FT	#SUB	75	  99 	LYS	E	79	 103 	SER	C	Protein	A	2
FT	#SUB	75	  99 	LYS	E	83	 107 	LYS	C	Protein	S	1
FT	#SUB	76	 100 	GLU	E	79	 103 	SER	C	Protein	A	4
FT	#SUB	79	 103 	SER	E	73	  97 	ASN	C	Protein	B	3
FT	#SUB	79	 103 	SER	E	75	  99 	LYS	C	Protein	A	4
FT	#SUB	79	 103 	SER	E	76	 100 	GLU	C	Protein	S	4
FT	#SUB	79	 103 	SER	E	126	 150 	GLU	C	Protein	B	1
FT	#SUB	80	 104 	LYS	E	76	 100 	GLU	C	Protein	S	5
FT	#SUB	80	 104 	LYS	E	126	 150 	GLU	C	Protein	B	2
FT	#SUB	81	 105 	GLY	E	126	 150 	GLU	C	Protein	B	1
FT	#SUB	126	 150 	GLU	E	58	  82 	LYS	C	Protein	S	1
FT	#SUB	128	 152 	ASP	E	270	 294 	GLU	C	Protein	S	2
FT	#SUB	270	 294 	GLU	E	128	 152 	ASP	C	Protein	S	2
FT	#SUB	21	  45 	VAL	E	180	 204 	VAL	F	Protein	S	1
FT	#SUB	21	  45 	VAL	E	181	 205 	ASN	F	Protein	S	2
FT	#SUB	23	  47 	LYS	E	149	 173 	ASP	F	Protein	S	6
FT	#SUB	23	  47 	LYS	E	178	 202 	TYR	F	Protein	S	4
FT	#SUB	23	  47 	LYS	E	179	 203 	VAL	F	Protein	S	2
FT	#SUB	24	  48 	ASP	E	149	 173 	ASP	F	Protein	A	6
FT	#SUB	25	  49 	ASP	E	151	 175 	ARG	F	Protein	S	1
FT	#SUB	31	  55 	THR	E	151	 175 	ARG	F	Protein	S	1
FT	#SUB	33	  57 	SER	E	178	 202 	TYR	F	Protein	A	6
FT	#SUB	35	  59 	PHE	E	40	  64 	ARG	F	Protein	B	4
FT	#SUB	35	  59 	PHE	E	176	 200 	GLN	F	Protein	S	3
FT	#SUB	35	  59 	PHE	E	178	 202 	TYR	F	Protein	S	18
FT	#SUB	35	  59 	PHE	E	185	 209 	SER	F	Protein	S	1
FT	#SUB	35	  59 	PHE	E	186	 210 	CYS	F	Protein	S	2
FT	#SUB	35	  59 	PHE	E	187	 211 	GLN	F	Protein	S	4
FT	#SUB	35	  59 	PHE	E	225	 249 	ILE	F	Protein	S	1
FT	#SUB	36	  60 	GLY	E	38	  62 	GLN	F	Protein	B	2
FT	#SUB	36	  60 	GLY	E	40	  64 	ARG	F	Protein	B	2
FT	#SUB	36	  60 	GLY	E	187	 211 	GLN	F	Protein	B	1
FT	#SUB	37	  61 	MET	E	38	  62 	GLN	F	Protein	B	9
FT	#SUB	38	  62 	GLN	E	36	  60 	GLY	F	Protein	S	2
FT	#SUB	38	  62 	GLN	E	37	  61 	MET	F	Protein	S	9
FT	#SUB	38	  62 	GLN	E	38	  62 	GLN	F	Protein	A	7
FT	#SUB	38	  62 	GLN	E	227	 251 	THR	F	Protein	S	1
FT	#SUB	40	  64 	ARG	E	35	  59 	PHE	F	Protein	S	4
FT	#SUB	40	  64 	ARG	E	36	  60 	GLY	F	Protein	S	2
FT	#SUB	118	 142 	PHE	E	159	 183 	ASN	F	Protein	S	1
FT	#SUB	118	 142 	PHE	E	160	 184 	PRO	F	Protein	S	7
FT	#SUB	134	 158 	VAL	E	160	 184 	PRO	F	Protein	S	1
FT	#SUB	136	 160 	GLN	E	160	 184 	PRO	F	Protein	S	3
FT	#SUB	148	 172 	PRO	E	23	  47 	LYS	F	Protein	B	1
FT	#SUB	149	 173 	ASP	E	23	  47 	LYS	F	Protein	A	4
FT	#SUB	151	 175 	ARG	E	31	  55 	THR	F	Protein	S	1
FT	#SUB	151	 175 	ARG	E	191	 215 	ARG	F	Protein	A	7
FT	#SUB	151	 175 	ARG	E	192	 216 	SER	F	Protein	S	2
FT	#SUB	151	 175 	ARG	E	230	 254 	ASP	F	Protein	S	6
FT	#SUB	151	 175 	ARG	E	232	 256 	HIS	F	Protein	S	8
FT	#SUB	151	 175 	ARG	E	234	 258 	TYR	F	Protein	S	2
FT	#SUB	152	 176 	ARG	E	158	 182 	TRP	F	Protein	B	1
FT	#SUB	152	 176 	ARG	E	169	 193 	PRO	F	Protein	S	4
FT	#SUB	152	 176 	ARG	E	191	 215 	ARG	F	Protein	S	4
FT	#SUB	154	 178 	ILE	E	158	 182 	TRP	F	Protein	S	7
FT	#SUB	154	 178 	ILE	E	191	 215 	ARG	F	Protein	S	2
FT	#SUB	156	 180 	CYS	E	156	 180 	CYS	F	Protein	S	1
FT	#SUB	156	 180 	CYS	E	158	 182 	TRP	F	Protein	S	1
FT	#SUB	158	 182 	TRP	E	152	 176 	ARG	F	Protein	S	2
FT	#SUB	158	 182 	TRP	E	154	 178 	ILE	F	Protein	S	7
FT	#SUB	158	 182 	TRP	E	156	 180 	CYS	F	Protein	S	1
FT	#SUB	159	 183 	ASN	E	118	 142 	PHE	F	Protein	S	1
FT	#SUB	160	 184 	PRO	E	118	 142 	PHE	F	Protein	S	6
FT	#SUB	160	 184 	PRO	E	134	 158 	VAL	F	Protein	B	2
FT	#SUB	160	 184 	PRO	E	136	 160 	GLN	F	Protein	S	2
FT	#SUB	169	 193 	PRO	E	152	 176 	ARG	F	Protein	S	4
FT	#SUB	173	 197 	ALA	E	174	 198 	LEU	F	Protein	S	1
FT	#SUB	174	 198 	LEU	E	173	 197 	ALA	F	Protein	S	1
FT	#SUB	174	 198 	LEU	E	189	 213 	TYR	F	Protein	S	1
FT	#SUB	176	 200 	GLN	E	35	  59 	PHE	F	Protein	A	5
FT	#SUB	176	 200 	GLN	E	189	 213 	TYR	F	Protein	S	6
FT	#SUB	176	 200 	GLN	E	191	 215 	ARG	F	Protein	S	10
FT	#SUB	176	 200 	GLN	E	229	 253 	GLY	F	Protein	S	1
FT	#SUB	178	 202 	TYR	E	23	  47 	LYS	F	Protein	S	6
FT	#SUB	178	 202 	TYR	E	33	  57 	SER	F	Protein	S	6
FT	#SUB	178	 202 	TYR	E	35	  59 	PHE	F	Protein	S	17
FT	#SUB	178	 202 	TYR	E	230	 254 	ASP	F	Protein	S	3
FT	#SUB	179	 203 	VAL	E	23	  47 	LYS	F	Protein	B	4
FT	#SUB	180	 204 	VAL	E	21	  45 	VAL	F	Protein	S	1
FT	#SUB	181	 205 	ASN	E	21	  45 	VAL	F	Protein	S	1
FT	#SUB	185	 209 	SER	E	35	  59 	PHE	F	Protein	S	1
FT	#SUB	186	 210 	CYS	E	35	  59 	PHE	F	Protein	B	1
FT	#SUB	187	 211 	GLN	E	35	  59 	PHE	F	Protein	A	4
FT	#SUB	187	 211 	GLN	E	36	  60 	GLY	F	Protein	S	1
FT	#SUB	187	 211 	GLN	E	189	 213 	TYR	F	Protein	S	9
FT	#SUB	187	 211 	GLN	E	227	 251 	THR	F	Protein	S	1
FT	#SUB	187	 211 	GLN	E	228	 252 	LEU	F	Protein	S	3
FT	#SUB	187	 211 	GLN	E	229	 253 	GLY	F	Protein	S	2
FT	#SUB	189	 213 	TYR	E	174	 198 	LEU	F	Protein	S	1
FT	#SUB	189	 213 	TYR	E	176	 200 	GLN	F	Protein	S	5
FT	#SUB	189	 213 	TYR	E	187	 211 	GLN	F	Protein	S	8
FT	#SUB	191	 215 	ARG	E	151	 175 	ARG	F	Protein	S	6
FT	#SUB	191	 215 	ARG	E	152	 176 	ARG	F	Protein	S	4
FT	#SUB	191	 215 	ARG	E	154	 178 	ILE	F	Protein	S	2
FT	#SUB	191	 215 	ARG	E	176	 200 	GLN	F	Protein	A	9
FT	#SUB	192	 216 	SER	E	151	 175 	ARG	F	Protein	S	1
FT	#SUB	225	 249 	ILE	E	35	  59 	PHE	F	Protein	S	4
FT	#SUB	227	 251 	THR	E	38	  62 	GLN	F	Protein	S	1
FT	#SUB	227	 251 	THR	E	187	 211 	GLN	F	Protein	S	1
FT	#SUB	227	 251 	THR	E	227	 251 	THR	F	Protein	S	3
FT	#SUB	228	 252 	LEU	E	187	 211 	GLN	F	Protein	B	4
FT	#SUB	229	 253 	GLY	E	176	 200 	GLN	F	Protein	B	1
FT	#SUB	229	 253 	GLY	E	187	 211 	GLN	F	Protein	B	1
FT	#SUB	230	 254 	ASP	E	151	 175 	ARG	F	Protein	S	4
FT	#SUB	230	 254 	ASP	E	178	 202 	TYR	F	Protein	S	3
FT	#SUB	232	 256 	HIS	E	151	 175 	ARG	F	Protein	S	8
FT	#SUB	234	 258 	TYR	E	151	 175 	ARG	F	Protein	S	5
FT	#HET	151	 175 	ARG	E	6	400 	DC	F	S	9
FT	#HET	152	 176 	ARG	E	6	400 	DC	F	S	5
FT	#HET	171	 195 	CYS	E	5	400 	DC	E	S	5
FT	#HET	172	 196 	HIS	E	5	400 	DC	E	S	2
FT	#HET	190	 214 	GLN	E	5	400 	DC	E	S	3
FT	#HET	191	 215 	ARG	E	5	400 	DC	E	S	8
FT	#HET	192	 216 	SER	E	5	400 	DC	E	S	4
FT	#HET	193	 217 	GLY	E	5	400 	DC	E	B	1
FT	#HET	194	 218 	ASP	E	5	400 	DC	E	A	7
FT	#HET	198	 222 	GLY	E	5	400 	DC	E	B	1
FT	#HET	202	 226 	ASN	E	5	400 	DC	E	S	6
FT	#HET	232	 256 	HIS	E	5	400 	DC	E	S	7
FT	#HET	234	 258 	TYR	E	5	400 	DC	E	S	4
FT	DISORDER	287	289
CC	SEQUENCE	286 AA (ATOM);
CC	MPPHGELQYL GQIQHILRCG VRKDDRTGTG TLSVFGMQAR YSLRDEFPLL TTKRVFWKGV
CC	LEELLWFIKG STNAKELSSK GVKIWDANGS RDFLDSLGFS TREEGDLGPV YGFQWRHFGA
CC	EYRDMESDYS GQGVDQLQRV IDTIKTNPDD RRIIMCAWNP RDLPLMALPP CHALCQFYVV
CC	NSELSCQLYQ RSGDMGLGVP FNIASYALLT YMIAHITGLK PGDFIHTLGD AHIYLNHIEP
CC	LKIQLQREPR PFPKLRILRK VEKIDDFKAE DFQIEGYNPH PTIKME
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLL
CC	ATOM   MPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLL
CC	       **************************************************
CC	SEQRES TTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFS
CC	ATOM   TTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFS
CC	       **************************************************
CC	SEQRES TREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDD
CC	ATOM   TREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDD
CC	       **************************************************
CC	SEQRES RRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVP
CC	ATOM   RRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVP
CC	       **************************************************
CC	SEQRES FNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPR
CC	ATOM   FNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPR
CC	       **************************************************
CC	SEQRES PFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV
CC	ATOM   PFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKME---
CC	       ************************************   
SQ	SEQUENCE	289 AA;      MW;         CN;
	MPPHGELQYL GQIQHILRCG VRKDDRTGTG TLSVFGMQAR YSLRDEFPLL TTKRVFWKGV
	LEELLWFIKG STNAKELSSK GVKIWDANGS RDFLDSLGFS TREEGDLGPV YGFQWRHFGA
	EYRDMESDYS GQGVDQLQRV IDTIKTNPDD RRIIMCAWNP RDLPLMALPP CHALCQFYVV
	NSELSCQLYQ RSGDMGLGVP FNIASYALLT YMIAHITGLK PGDFIHTLGD AHIYLNHIEP
	LKIQLQREPR PFPKLRILRK VEKIDDFKAE DFQIEGYNPH PTIKMEMAV
//
ID	5WRNF	STANDARD;	PRT;	289	AA.
DT	CONVERTED FROM PDB (SEQRES) 5WRN
DE	Thymidylate synthase
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.390
CC	R-Factor	0.191
FT	#SUB	101	 125 	THR	F	103	 127 	GLU	A	Protein	S	1
FT	#SUB	121	 145 	GLU	F	121	 145 	GLU	A	Protein	S	3
FT	#SUB	124	 148 	ASP	F	101	 125 	THR	A	Protein	S	4
FT	#SUB	21	  45 	VAL	F	180	 204 	VAL	E	Protein	S	1
FT	#SUB	21	  45 	VAL	F	181	 205 	ASN	E	Protein	S	1
FT	#SUB	23	  47 	LYS	F	148	 172 	PRO	E	Protein	S	1
FT	#SUB	23	  47 	LYS	F	149	 173 	ASP	E	Protein	S	4
FT	#SUB	23	  47 	LYS	F	178	 202 	TYR	E	Protein	S	6
FT	#SUB	23	  47 	LYS	F	179	 203 	VAL	E	Protein	S	4
FT	#SUB	31	  55 	THR	F	151	 175 	ARG	E	Protein	S	1
FT	#SUB	33	  57 	SER	F	178	 202 	TYR	E	Protein	A	6
FT	#SUB	35	  59 	PHE	F	40	  64 	ARG	E	Protein	B	4
FT	#SUB	35	  59 	PHE	F	176	 200 	GLN	E	Protein	S	5
FT	#SUB	35	  59 	PHE	F	178	 202 	TYR	E	Protein	S	17
FT	#SUB	35	  59 	PHE	F	185	 209 	SER	E	Protein	S	1
FT	#SUB	35	  59 	PHE	F	186	 210 	CYS	E	Protein	S	1
FT	#SUB	35	  59 	PHE	F	187	 211 	GLN	E	Protein	S	4
FT	#SUB	35	  59 	PHE	F	225	 249 	ILE	E	Protein	A	4
FT	#SUB	36	  60 	GLY	F	38	  62 	GLN	E	Protein	B	2
FT	#SUB	36	  60 	GLY	F	40	  64 	ARG	E	Protein	B	2
FT	#SUB	36	  60 	GLY	F	187	 211 	GLN	E	Protein	B	1
FT	#SUB	37	  61 	MET	F	38	  62 	GLN	E	Protein	B	9
FT	#SUB	38	  62 	GLN	F	36	  60 	GLY	E	Protein	S	2
FT	#SUB	38	  62 	GLN	F	37	  61 	MET	E	Protein	S	9
FT	#SUB	38	  62 	GLN	F	38	  62 	GLN	E	Protein	A	7
FT	#SUB	38	  62 	GLN	F	227	 251 	THR	E	Protein	S	1
FT	#SUB	40	  64 	ARG	F	35	  59 	PHE	E	Protein	S	4
FT	#SUB	40	  64 	ARG	F	36	  60 	GLY	E	Protein	S	2
FT	#SUB	118	 142 	PHE	F	159	 183 	ASN	E	Protein	S	1
FT	#SUB	118	 142 	PHE	F	160	 184 	PRO	E	Protein	S	6
FT	#SUB	134	 158 	VAL	F	160	 184 	PRO	E	Protein	S	2
FT	#SUB	136	 160 	GLN	F	160	 184 	PRO	E	Protein	S	2
FT	#SUB	149	 173 	ASP	F	23	  47 	LYS	E	Protein	A	6
FT	#SUB	149	 173 	ASP	F	24	  48 	ASP	E	Protein	S	6
FT	#SUB	151	 175 	ARG	F	25	  49 	ASP	E	Protein	S	1
FT	#SUB	151	 175 	ARG	F	31	  55 	THR	E	Protein	S	1
FT	#SUB	151	 175 	ARG	F	191	 215 	ARG	E	Protein	A	6
FT	#SUB	151	 175 	ARG	F	192	 216 	SER	E	Protein	S	1
FT	#SUB	151	 175 	ARG	F	230	 254 	ASP	E	Protein	S	4
FT	#SUB	151	 175 	ARG	F	232	 256 	HIS	E	Protein	S	8
FT	#SUB	151	 175 	ARG	F	234	 258 	TYR	E	Protein	S	5
FT	#SUB	152	 176 	ARG	F	158	 182 	TRP	E	Protein	A	2
FT	#SUB	152	 176 	ARG	F	169	 193 	PRO	E	Protein	S	4
FT	#SUB	152	 176 	ARG	F	191	 215 	ARG	E	Protein	S	4
FT	#SUB	154	 178 	ILE	F	158	 182 	TRP	E	Protein	S	7
FT	#SUB	154	 178 	ILE	F	191	 215 	ARG	E	Protein	S	2
FT	#SUB	156	 180 	CYS	F	156	 180 	CYS	E	Protein	S	1
FT	#SUB	156	 180 	CYS	F	158	 182 	TRP	E	Protein	S	1
FT	#SUB	158	 182 	TRP	F	152	 176 	ARG	E	Protein	S	1
FT	#SUB	158	 182 	TRP	F	154	 178 	ILE	E	Protein	S	7
FT	#SUB	158	 182 	TRP	F	156	 180 	CYS	E	Protein	S	1
FT	#SUB	159	 183 	ASN	F	118	 142 	PHE	E	Protein	S	1
FT	#SUB	160	 184 	PRO	F	118	 142 	PHE	E	Protein	S	7
FT	#SUB	160	 184 	PRO	F	134	 158 	VAL	E	Protein	B	1
FT	#SUB	160	 184 	PRO	F	136	 160 	GLN	E	Protein	S	3
FT	#SUB	169	 193 	PRO	F	152	 176 	ARG	E	Protein	S	4
FT	#SUB	173	 197 	ALA	F	174	 198 	LEU	E	Protein	S	1
FT	#SUB	174	 198 	LEU	F	173	 197 	ALA	E	Protein	S	1
FT	#SUB	174	 198 	LEU	F	189	 213 	TYR	E	Protein	S	1
FT	#SUB	176	 200 	GLN	F	35	  59 	PHE	E	Protein	A	3
FT	#SUB	176	 200 	GLN	F	189	 213 	TYR	E	Protein	S	5
FT	#SUB	176	 200 	GLN	F	191	 215 	ARG	E	Protein	S	9
FT	#SUB	176	 200 	GLN	F	229	 253 	GLY	E	Protein	S	1
FT	#SUB	178	 202 	TYR	F	23	  47 	LYS	E	Protein	S	4
FT	#SUB	178	 202 	TYR	F	33	  57 	SER	E	Protein	S	6
FT	#SUB	178	 202 	TYR	F	35	  59 	PHE	E	Protein	S	18
FT	#SUB	178	 202 	TYR	F	230	 254 	ASP	E	Protein	S	3
FT	#SUB	179	 203 	VAL	F	23	  47 	LYS	E	Protein	B	2
FT	#SUB	180	 204 	VAL	F	21	  45 	VAL	E	Protein	S	1
FT	#SUB	181	 205 	ASN	F	21	  45 	VAL	E	Protein	S	2
FT	#SUB	185	 209 	SER	F	35	  59 	PHE	E	Protein	S	1
FT	#SUB	186	 210 	CYS	F	35	  59 	PHE	E	Protein	B	2
FT	#SUB	187	 211 	GLN	F	35	  59 	PHE	E	Protein	A	4
FT	#SUB	187	 211 	GLN	F	36	  60 	GLY	E	Protein	S	1
FT	#SUB	187	 211 	GLN	F	189	 213 	TYR	E	Protein	S	8
FT	#SUB	187	 211 	GLN	F	227	 251 	THR	E	Protein	S	1
FT	#SUB	187	 211 	GLN	F	228	 252 	LEU	E	Protein	S	4
FT	#SUB	187	 211 	GLN	F	229	 253 	GLY	E	Protein	S	1
FT	#SUB	189	 213 	TYR	F	174	 198 	LEU	E	Protein	S	1
FT	#SUB	189	 213 	TYR	F	176	 200 	GLN	E	Protein	S	6
FT	#SUB	189	 213 	TYR	F	187	 211 	GLN	E	Protein	S	9
FT	#SUB	191	 215 	ARG	F	151	 175 	ARG	E	Protein	A	7
FT	#SUB	191	 215 	ARG	F	152	 176 	ARG	E	Protein	S	4
FT	#SUB	191	 215 	ARG	F	154	 178 	ILE	E	Protein	S	2
FT	#SUB	191	 215 	ARG	F	176	 200 	GLN	E	Protein	A	10
FT	#SUB	192	 216 	SER	F	151	 175 	ARG	E	Protein	S	2
FT	#SUB	225	 249 	ILE	F	35	  59 	PHE	E	Protein	S	1
FT	#SUB	227	 251 	THR	F	38	  62 	GLN	E	Protein	S	1
FT	#SUB	227	 251 	THR	F	187	 211 	GLN	E	Protein	S	1
FT	#SUB	227	 251 	THR	F	227	 251 	THR	E	Protein	S	3
FT	#SUB	228	 252 	LEU	F	187	 211 	GLN	E	Protein	B	3
FT	#SUB	229	 253 	GLY	F	176	 200 	GLN	E	Protein	B	1
FT	#SUB	229	 253 	GLY	F	187	 211 	GLN	E	Protein	B	2
FT	#SUB	230	 254 	ASP	F	151	 175 	ARG	E	Protein	S	6
FT	#SUB	230	 254 	ASP	F	178	 202 	TYR	E	Protein	S	3
FT	#SUB	232	 256 	HIS	F	151	 175 	ARG	E	Protein	S	8
FT	#SUB	234	 258 	TYR	F	151	 175 	ARG	E	Protein	S	2
FT	#HET	151	 175 	ARG	F	5	400 	DC	E	S	9
FT	#HET	152	 176 	ARG	F	5	400 	DC	E	S	6
FT	#HET	171	 195 	CYS	F	6	400 	DC	F	S	4
FT	#HET	172	 196 	HIS	F	6	400 	DC	F	S	2
FT	#HET	190	 214 	GLN	F	6	400 	DC	F	S	2
FT	#HET	191	 215 	ARG	F	6	400 	DC	F	S	8
FT	#HET	192	 216 	SER	F	6	400 	DC	F	A	6
FT	#HET	193	 217 	GLY	F	6	400 	DC	F	B	2
FT	#HET	194	 218 	ASP	F	6	400 	DC	F	A	9
FT	#HET	198	 222 	GLY	F	6	400 	DC	F	B	2
FT	#HET	202	 226 	ASN	F	6	400 	DC	F	S	9
FT	#HET	232	 256 	HIS	F	6	400 	DC	F	S	7
FT	#HET	234	 258 	TYR	F	6	400 	DC	F	S	3
FT	DISORDER	25	29
FT	DISORDER	283	289
CC	SEQUENCE	277 AA (ATOM);
CC	MPPHGELQYL GQIQHILRCG VRKDGTLSVF GMQARYSLRD EFPLLTTKRV FWKGVLEELL
CC	WFIKGSTNAK ELSSKGVKIW DANGSRDFLD SLGFSTREEG DLGPVYGFQW RHFGAEYRDM
CC	ESDYSGQGVD QLQRVIDTIK TNPDDRRIIM CAWNPRDLPL MALPPCHALC QFYVVNSELS
CC	CQLYQRSGDM GLGVPFNIAS YALLTYMIAH ITGLKPGDFI HTLGDAHIYL NHIEPLKIQL
CC	QREPRPFPKL RILRKVEKID DFKAEDFQIE GYNPHPT
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLL
CC	ATOM   MPPHGELQYLGQIQHILRCGVRKD-----GTLSVFGMQARYSLRDEFPLL
CC	       ************************     *********************
CC	SEQRES TTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFS
CC	ATOM   TTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFS
CC	       **************************************************
CC	SEQRES TREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDD
CC	ATOM   TREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDD
CC	       **************************************************
CC	SEQRES RRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVP
CC	ATOM   RRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVP
CC	       **************************************************
CC	SEQRES FNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPR
CC	ATOM   FNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPR
CC	       **************************************************
CC	SEQRES PFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV
CC	ATOM   PFPKLRILRKVEKIDDFKAEDFQIEGYNPHPT-------
CC	       ********************************       
SQ	SEQUENCE	289 AA;      MW;         CN;
	MPPHGELQYL GQIQHILRCG VRKDDRTGTG TLSVFGMQAR YSLRDEFPLL TTKRVFWKGV
	LEELLWFIKG STNAKELSSK GVKIWDANGS RDFLDSLGFS TREEGDLGPV YGFQWRHFGA
	EYRDMESDYS GQGVDQLQRV IDTIKTNPDD RRIIMCAWNP RDLPLMALPP CHALCQFYVV
	NSELSCQLYQ RSGDMGLGVP FNIASYALLT YMIAHITGLK PGDFIHTLGD AHIYLNHIEP
	LKIQLQREPR PFPKLRILRK VEKIDDFKAE DFQIEGYNPH PTIKMEMAV
//