ID 5VP1A STANDARD; PRT; 345 AA. DT CONVERTED FROM PDB (SEQRES) 5VP1 DE cGMP-dependent 3',5'-cyclic phosphodiesterase OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.860 CC R-Factor 0.225 FT #SUB 136 710 ALA A 177 751 ARG B Protein B 3 FT #SUB 137 711 SER A 177 751 ARG B Protein B 2 FT #SUB 138 712 LYS A 177 751 ARG B Protein S 5 FT #SUB 138 712 LYS A 181 755 GLN B Protein S 5 FT #SUB 140 714 VAL A 161 735 ILE B Protein S 1 FT #SUB 140 714 VAL A 165 739 ASN B Protein S 4 FT #SUB 143 717 ALA A 157 731 PHE B Protein B 2 FT #SUB 143 717 ALA A 184 758 LEU B Protein S 1 FT #SUB 143 717 ALA A 188 762 ARG B Protein B 1 FT #SUB 144 718 LEU A 158 732 ALA B Protein S 2 FT #SUB 144 718 LEU A 161 735 ILE B Protein S 2 FT #SUB 147 721 SER A 188 762 ARG B Protein S 2 FT #SUB 148 722 GLU A 148 722 GLU B Protein S 9 FT #SUB 148 722 GLU A 154 728 ARG B Protein S 2 FT #SUB 154 728 ARG A 148 722 GLU B Protein S 3 FT #SUB 157 731 PHE A 143 717 ALA B Protein S 2 FT #SUB 158 732 ALA A 144 718 LEU B Protein B 1 FT #SUB 161 735 ILE A 140 714 VAL B Protein S 1 FT #SUB 165 739 ASN A 140 714 VAL B Protein S 4 FT #SUB 177 751 ARG A 138 712 LYS B Protein A 3 FT #SUB 177 751 ARG A 266 840 MET B Protein S 5 FT #SUB 177 751 ARG A 268 842 ASN B Protein S 2 FT #SUB 181 755 GLN A 138 712 LYS B Protein S 8 FT #SUB 184 758 LEU A 143 717 ALA B Protein S 1 FT #SUB 188 762 ARG A 143 717 ALA B Protein S 4 FT #SUB 266 840 MET A 177 751 ARG B Protein S 1 FT #SUB 167 741 HIS A 220 794 GLN C Protein S 14 FT #SUB 167 741 HIS A 223 797 ARG C Protein S 2 FT #HET 81 655 TYR A 4 1004 9GA A S 1 FT #HET 82 656 HIS A 4 1004 9GA A S 3 FT #HET 86 660 HIS A 1 1001 ZN A S 3 FT #HET 122 696 HIS A 1 1001 ZN A S 3 FT #HET 123 697 ASP A 1 1001 ZN A S 3 FT #HET 123 697 ASP A 2 1002 MG A S 3 FT #HET 194 768 THR A 4 1004 9GA A B 2 FT #HET 196 770 LEU A 4 1004 9GA A A 6 FT #HET 199 773 HIS A 4 1004 9GA A S 4 FT #HET 211 785 GLU A 3 1003 MG A A 4 FT #HET 231 805 THR A 4 1004 9GA A A 8 FT #HET 234 808 ASP A 1 1001 ZN A S 3 FT #HET 234 808 ASP A 4 1004 9GA A S 2 FT #HET 235 809 LEU A 4 1004 9GA A S 8 FT #HET 238 812 GLN A 4 1004 9GA A S 2 FT #HET 252 826 ILE A 4 1004 9GA A S 6 FT #HET 253 827 TYR A 4 1004 9GA A S 2 FT #HET 256 830 PHE A 4 1004 9GA A S 3 FT #HET 273 847 MET A 4 1004 9GA A S 9 FT #HET 284 858 LEU A 4 1004 9GA A A 3 FT #HET 285 859 GLN A 4 1004 9GA A S 3 FT #HET 288 862 PHE A 4 1004 9GA A S 36 FT #HET 292 866 ILE A 4 1004 9GA A S 1 FT #HET 296 870 ILE A 4 1004 9GA A S 1 FT DISORDER 1 4 FT DISORDER 343 345 CC SEQUENCE 338 AA (ATOM); CC DDEYTKLLHD GIQPVAAIDS NFASFTYTPR SLPEDDTSMA ILSMLQDMNF INNYKIDCPT CC LARFCLMVKK GYRDPPYHNW MHAFSVSHFC YLLYKNLELT NYLEDIEIFA LFISCMCHDL CC DHRGTNNSFQ VASKSVLAAL YSSEGSVMER HHFAQAIAIL NTHGCNIFDH FSRKDYQRML CC DLMRDIILAT DLAHHLRIFK DLQKMAEVGY DRNNKQHHRL LLCLLMTSCD LSDQTKGWKT CC TRKIAELIYK EFFSQGDLEK AMGNRPMEMM DREKAYIPEL QISFMEHIAM PIYKLLQDLF CC PKAAELYERV ASNREHWTKV SHKFTIRGLP SNNSLDFL CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GHASDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQ CC ATOM ----DDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQ CC ********************************************** CC SEQRES DMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKN CC ATOM DMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKN CC ************************************************** CC SEQRES LELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGS CC ATOM LELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGS CC ************************************************** CC SEQRES VMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL CC ATOM VMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL CC ************************************************** CC SEQRES RIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAE CC ATOM RIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAE CC ************************************************** CC SEQRES LIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLL CC ATOM LIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLL CC ************************************************** CC SEQRES QDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEE CC ATOM QDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFL--- CC ****************************************** SQ SEQUENCE 345 AA; MW; CN; GHASDDEYTK LLHDGIQPVA AIDSNFASFT YTPRSLPEDD TSMAILSMLQ DMNFINNYKI DCPTLARFCL MVKKGYRDPP YHNWMHAFSV SHFCYLLYKN LELTNYLEDI EIFALFISCM CHDLDHRGTN NSFQVASKSV LAALYSSEGS VMERHHFAQA IAILNTHGCN IFDHFSRKDY QRMLDLMRDI ILATDLAHHL RIFKDLQKMA EVGYDRNNKQ HHRLLLCLLM TSCDLSDQTK GWKTTRKIAE LIYKEFFSQG DLEKAMGNRP MEMMDREKAY IPELQISFME HIAMPIYKLL QDLFPKAAEL YERVASNREH WTKVSHKFTI RGLPSNNSLD FLDEE // ID 5VP1B STANDARD; PRT; 345 AA. DT CONVERTED FROM PDB (SEQRES) 5VP1 DE cGMP-dependent 3',5'-cyclic phosphodiesterase OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.860 CC R-Factor 0.225 FT #SUB 138 712 LYS B 177 751 ARG A Protein S 3 FT #SUB 138 712 LYS B 181 755 GLN A Protein S 8 FT #SUB 140 714 VAL B 161 735 ILE A Protein S 1 FT #SUB 140 714 VAL B 165 739 ASN A Protein S 4 FT #SUB 143 717 ALA B 157 731 PHE A Protein B 2 FT #SUB 143 717 ALA B 184 758 LEU A Protein S 1 FT #SUB 143 717 ALA B 188 762 ARG A Protein B 4 FT #SUB 144 718 LEU B 158 732 ALA A Protein S 1 FT #SUB 148 722 GLU B 148 722 GLU A Protein S 9 FT #SUB 148 722 GLU B 154 728 ARG A Protein S 3 FT #SUB 154 728 ARG B 148 722 GLU A Protein S 2 FT #SUB 157 731 PHE B 143 717 ALA A Protein S 2 FT #SUB 158 732 ALA B 144 718 LEU A Protein A 2 FT #SUB 161 735 ILE B 140 714 VAL A Protein S 1 FT #SUB 161 735 ILE B 144 718 LEU A Protein S 2 FT #SUB 165 739 ASN B 140 714 VAL A Protein S 4 FT #SUB 177 751 ARG B 136 710 ALA A Protein S 3 FT #SUB 177 751 ARG B 137 711 SER A Protein S 2 FT #SUB 177 751 ARG B 138 712 LYS A Protein S 5 FT #SUB 177 751 ARG B 266 840 MET A Protein S 1 FT #SUB 181 755 GLN B 138 712 LYS A Protein S 5 FT #SUB 184 758 LEU B 143 717 ALA A Protein S 1 FT #SUB 188 762 ARG B 143 717 ALA A Protein S 1 FT #SUB 188 762 ARG B 147 721 SER A Protein S 2 FT #SUB 266 840 MET B 177 751 ARG A Protein A 5 FT #SUB 268 842 ASN B 177 751 ARG A Protein S 2 FT #SUB 2 576 HIS B 105 679 ASN C Protein S 5 FT #SUB 2 576 HIS B 216 790 ARG C Protein S 10 FT #SUB 77 651 ARG B 212 786 VAL C Protein S 6 FT #SUB 77 651 ARG B 213 787 GLY C Protein S 1 FT #SUB 262 836 LEU B 211 785 GLU C Protein S 4 FT #HET 81 655 TYR B 7 1003 9GA B S 1 FT #HET 82 656 HIS B 7 1003 9GA B S 2 FT #HET 86 660 HIS B 5 1001 ZN B S 3 FT #HET 122 696 HIS B 5 1001 ZN B S 3 FT #HET 123 697 ASP B 5 1001 ZN B S 3 FT #HET 123 697 ASP B 6 1002 MG B S 3 FT #HET 194 768 THR B 7 1003 9GA B B 3 FT #HET 196 770 LEU B 7 1003 9GA B A 7 FT #HET 199 773 HIS B 7 1003 9GA B S 4 FT #HET 231 805 THR B 7 1003 9GA B A 10 FT #HET 234 808 ASP B 5 1001 ZN B S 3 FT #HET 234 808 ASP B 7 1003 9GA B S 2 FT #HET 235 809 LEU B 7 1003 9GA B S 8 FT #HET 238 812 GLN B 7 1003 9GA B S 2 FT #HET 252 826 ILE B 7 1003 9GA B S 6 FT #HET 253 827 TYR B 7 1003 9GA B S 2 FT #HET 256 830 PHE B 7 1003 9GA B S 2 FT #HET 273 847 MET B 7 1003 9GA B S 9 FT #HET 284 858 LEU B 7 1003 9GA B B 2 FT #HET 285 859 GLN B 7 1003 9GA B S 3 FT #HET 288 862 PHE B 7 1003 9GA B S 37 FT #HET 292 866 ILE B 7 1003 9GA B S 1 FT #HET 296 870 ILE B 7 1003 9GA B S 1 FT DISORDER 343 345 CC SEQUENCE 342 AA (ATOM); CC GHASDDEYTK LLHDGIQPVA AIDSNFASFT YTPRSLPEDD TSMAILSMLQ DMNFINNYKI CC DCPTLARFCL MVKKGYRDPP YHNWMHAFSV SHFCYLLYKN LELTNYLEDI EIFALFISCM CC CHDLDHRGTN NSFQVASKSV LAALYSSEGS VMERHHFAQA IAILNTHGCN IFDHFSRKDY CC QRMLDLMRDI ILATDLAHHL RIFKDLQKMA EVGYDRNNKQ HHRLLLCLLM TSCDLSDQTK CC GWKTTRKIAE LIYKEFFSQG DLEKAMGNRP MEMMDREKAY IPELQISFME HIAMPIYKLL CC QDLFPKAAEL YERVASNREH WTKVSHKFTI RGLPSNNSLD FL CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GHASDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQ CC ATOM GHASDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQ CC ************************************************** CC SEQRES DMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKN CC ATOM DMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKN CC ************************************************** CC SEQRES LELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGS CC ATOM LELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGS CC ************************************************** CC SEQRES VMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL CC ATOM VMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL CC ************************************************** CC SEQRES RIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAE CC ATOM RIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAE CC ************************************************** CC SEQRES LIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLL CC ATOM LIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLL CC ************************************************** CC SEQRES QDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEE CC ATOM QDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFL--- CC ****************************************** SQ SEQUENCE 345 AA; MW; CN; GHASDDEYTK LLHDGIQPVA AIDSNFASFT YTPRSLPEDD TSMAILSMLQ DMNFINNYKI DCPTLARFCL MVKKGYRDPP YHNWMHAFSV SHFCYLLYKN LELTNYLEDI EIFALFISCM CHDLDHRGTN NSFQVASKSV LAALYSSEGS VMERHHFAQA IAILNTHGCN IFDHFSRKDY QRMLDLMRDI ILATDLAHHL RIFKDLQKMA EVGYDRNNKQ HHRLLLCLLM TSCDLSDQTK GWKTTRKIAE LIYKEFFSQG DLEKAMGNRP MEMMDREKAY IPELQISFME HIAMPIYKLL QDLFPKAAEL YERVASNREH WTKVSHKFTI RGLPSNNSLD FLDEE // ID 5VP1C STANDARD; PRT; 345 AA. DT CONVERTED FROM PDB (SEQRES) 5VP1 DE cGMP-dependent 3',5'-cyclic phosphodiesterase OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.860 CC R-Factor 0.225 FT #SUB 220 794 GLN C 167 741 HIS A Protein S 14 FT #SUB 223 797 ARG C 167 741 HIS A Protein S 2 FT #SUB 105 679 ASN C 2 576 HIS B Protein A 5 FT #SUB 211 785 GLU C 262 836 LEU B Protein S 4 FT #SUB 212 786 VAL C 77 651 ARG B Protein A 6 FT #SUB 213 787 GLY C 77 651 ARG B Protein B 1 FT #SUB 216 790 ARG C 2 576 HIS B Protein S 10 FT #HET 81 655 TYR C 10 1003 9GA C S 1 FT #HET 82 656 HIS C 10 1003 9GA C S 3 FT #HET 86 660 HIS C 8 1001 ZN C S 3 FT #HET 122 696 HIS C 8 1001 ZN C S 3 FT #HET 123 697 ASP C 8 1001 ZN C S 3 FT #HET 123 697 ASP C 9 1002 MG C S 3 FT #HET 194 768 THR C 10 1003 9GA C B 2 FT #HET 196 770 LEU C 10 1003 9GA C A 6 FT #HET 199 773 HIS C 10 1003 9GA C S 4 FT #HET 231 805 THR C 10 1003 9GA C A 7 FT #HET 234 808 ASP C 8 1001 ZN C S 3 FT #HET 234 808 ASP C 10 1003 9GA C S 2 FT #HET 235 809 LEU C 10 1003 9GA C S 8 FT #HET 238 812 GLN C 10 1003 9GA C S 2 FT #HET 252 826 ILE C 10 1003 9GA C S 7 FT #HET 253 827 TYR C 10 1003 9GA C S 2 FT #HET 256 830 PHE C 10 1003 9GA C S 1 FT #HET 273 847 MET C 10 1003 9GA C S 5 FT #HET 284 858 LEU C 10 1003 9GA C B 2 FT #HET 285 859 GLN C 10 1003 9GA C S 4 FT #HET 288 862 PHE C 10 1003 9GA C S 31 FT #HET 292 866 ILE C 10 1003 9GA C S 1 FT #HET 296 870 ILE C 10 1003 9GA C S 1 FT DISORDER 1 15 FT DISORDER 135 148 FT DISORDER 343 345 CC SEQUENCE 313 AA (ATOM); CC IQPVAAIDSN FASFTYTPRS LPEDDTSMAI LSMLQDMNFI NNYKIDCPTL ARFCLMVKKG CC YRDPPYHNWM HAFSVSHFCY LLYKNLELTN YLEDIEIFAL FISCMCHDLD HRGTNNSFQG CC SVMERHHFAQ AIAILNTHGC NIFDHFSRKD YQRMLDLMRD IILATDLAHH LRIFKDLQKM CC AEVGYDRNNK QHHRLLLCLL MTSCDLSDQT KGWKTTRKIA ELIYKEFFSQ GDLEKAMGNR CC PMEMMDREKA YIPELQISFM EHIAMPIYKL LQDLFPKAAE LYERVASNRE HWTKVSHKFT CC IRGLPSNNSL DFL CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GHASDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQ CC ATOM ---------------IQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQ CC *********************************** CC SEQRES DMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKN CC ATOM DMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKN CC ************************************************** CC SEQRES LELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGS CC ATOM LELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQ--------------GS CC ********************************** ** CC SEQRES VMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL CC ATOM VMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL CC ************************************************** CC SEQRES RIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAE CC ATOM RIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAE CC ************************************************** CC SEQRES LIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLL CC ATOM LIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLL CC ************************************************** CC SEQRES QDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEE CC ATOM QDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFL--- CC ****************************************** SQ SEQUENCE 345 AA; MW; CN; GHASDDEYTK LLHDGIQPVA AIDSNFASFT YTPRSLPEDD TSMAILSMLQ DMNFINNYKI DCPTLARFCL MVKKGYRDPP YHNWMHAFSV SHFCYLLYKN LELTNYLEDI EIFALFISCM CHDLDHRGTN NSFQVASKSV LAALYSSEGS VMERHHFAQA IAILNTHGCN IFDHFSRKDY QRMLDLMRDI ILATDLAHHL RIFKDLQKMA EVGYDRNNKQ HHRLLLCLLM TSCDLSDQTK GWKTTRKIAE LIYKEFFSQG DLEKAMGNRP MEMMDREKAY IPELQISFME HIAMPIYKLL QDLFPKAAEL YERVASNREH WTKVSHKFTI RGLPSNNSLD FLDEE //