ID 5VILA STANDARD; PRT; 293 AA. DT CONVERTED FROM PDB (SEQRES) 5VIL DE Mitogen-activated protein kinase kinase kinase 5 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.640 CC R-Factor 0.182 FT #SUB 14 672 GLU A 120 778 GLN B Protein S 1 FT #SUB 18 676 GLU A 111 769 LYS B Protein S 1 FT #SUB 42 700 LEU A 118 776 ASN B Protein B 3 FT #SUB 42 700 LEU A 121 779 THR B Protein B 1 FT #SUB 43 701 SER A 120 778 GLN B Protein A 8 FT #SUB 43 701 SER A 121 779 THR B Protein B 5 FT #SUB 44 702 ASN A 121 779 THR B Protein B 3 FT #SUB 44 702 ASN A 124 782 PHE B Protein S 5 FT #SUB 44 702 ASN A 125 783 TYR B Protein B 4 FT #SUB 45 703 GLN A 112 770 TRP B Protein S 7 FT #SUB 45 703 GLN A 118 776 ASN B Protein S 1 FT #SUB 45 703 GLN A 121 779 THR B Protein S 2 FT #SUB 46 704 VAL A 125 783 TYR B Protein S 1 FT #SUB 46 704 VAL A 155 813 THR B Protein A 3 FT #SUB 46 704 VAL A 156 814 TYR B Protein S 2 FT #SUB 46 704 VAL A 158 816 GLY B Protein S 2 FT #SUB 47 705 ARG A 111 769 LYS B Protein S 1 FT #SUB 47 705 ARG A 155 813 THR B Protein A 8 FT #SUB 47 705 ARG A 156 814 TYR B Protein S 7 FT #SUB 98 756 GLN A 156 814 TYR B Protein B 2 FT #SUB 100 758 PRO A 100 758 PRO B Protein S 1 FT #SUB 100 758 PRO A 156 814 TYR B Protein A 13 FT #SUB 111 769 LYS A 18 676 GLU B Protein S 2 FT #SUB 111 769 LYS A 47 705 ARG B Protein S 2 FT #SUB 112 770 TRP A 45 703 GLN B Protein S 5 FT #SUB 118 776 ASN A 42 700 LEU B Protein S 3 FT #SUB 118 776 ASN A 45 703 GLN B Protein S 2 FT #SUB 120 778 GLN A 43 701 SER B Protein A 8 FT #SUB 121 779 THR A 42 700 LEU B Protein S 1 FT #SUB 121 779 THR A 43 701 SER B Protein A 5 FT #SUB 121 779 THR A 44 702 ASN B Protein S 3 FT #SUB 121 779 THR A 45 703 GLN B Protein S 3 FT #SUB 124 782 PHE A 44 702 ASN B Protein S 7 FT #SUB 125 783 TYR A 44 702 ASN B Protein S 4 FT #SUB 125 783 TYR A 46 704 VAL B Protein S 1 FT #SUB 155 813 THR A 46 704 VAL B Protein B 3 FT #SUB 155 813 THR A 47 705 ARG B Protein A 7 FT #SUB 156 814 TYR A 46 704 VAL B Protein B 2 FT #SUB 156 814 TYR A 47 705 ARG B Protein S 7 FT #SUB 156 814 TYR A 98 756 GLN B Protein S 3 FT #SUB 156 814 TYR A 100 758 PRO B Protein S 12 FT #SUB 158 816 GLY A 46 704 VAL B Protein B 2 FT #SUB 267 925 LYS A 264 922 ASP C Protein S 2 FT #SUB 267 925 LYS A 266 924 ASP C Protein S 1 FT #SUB 267 925 LYS A 267 925 LYS C Protein B 2 FT #HET 18 676 GLU A 4 1002 DMS B S 9 FT #HET 28 686 LEU A 1 1001 9E1 A A 13 FT #HET 29 687 GLY A 1 1001 9E1 A B 9 FT #HET 30 688 LYS A 1 1001 9E1 A B 14 FT #HET 31 689 GLY A 1 1001 9E1 A B 5 FT #HET 36 694 VAL A 1 1001 9E1 A S 11 FT #HET 40 698 ARG A 4 1002 DMS B S 5 FT #HET 45 703 GLN A 4 1002 DMS B A 10 FT #HET 47 705 ARG A 4 1002 DMS B S 3 FT #HET 49 707 ALA A 1 1001 9E1 A S 3 FT #HET 51 709 LYS A 1 1001 9E1 A S 6 FT #HET 80 738 VAL A 1 1001 9E1 A S 4 FT #HET 96 754 MET A 1 1001 9E1 A S 5 FT #HET 97 755 GLU A 1 1001 9E1 A B 6 FT #HET 98 756 GLN A 1 1001 9E1 A A 16 FT #HET 99 757 VAL A 1 1001 9E1 A A 19 FT #HET 100 758 PRO A 1 1001 9E1 A B 4 FT #HET 100 758 PRO A 2 1002 DMS A A 7 FT #HET 101 759 GLY A 1 1001 9E1 A B 3 FT #HET 101 759 GLY A 2 1002 DMS A B 7 FT #HET 102 760 GLY A 1 1001 9E1 A B 8 FT #HET 103 761 SER A 1 1001 9E1 A A 4 FT #HET 111 769 LYS A 5 1003 DMS B S 8 FT #HET 112 770 TRP A 5 1003 DMS B S 11 FT #HET 149 807 ASP A 1 1001 9E1 A B 5 FT #HET 150 808 ASN A 1 1001 9E1 A A 7 FT #HET 152 810 LEU A 1 1001 9E1 A S 10 FT #HET 155 813 THR A 5 1003 DMS B A 7 FT #HET 156 814 TYR A 2 1002 DMS A S 7 FT #HET 156 814 TYR A 3 1001 9E1 B S 6 FT #HET 156 814 TYR A 6 1004 DMS B S 1 FT #HET 163 821 SER A 1 1001 9E1 A S 6 FT #HET 164 822 ASP A 1 1001 9E1 A A 13 FT DISORDER 1 11 FT DISORDER 283 293 CC SEQUENCE 271 AA (ATOM); CC LLEYDYEYDE NGDRVVLGKG TYGIVYAGRD LSNQVRIAIK EIPERDSRYS QPLHEEIALH CC KHLKHKNIVQ YLGSFSENGF IKIFMEQVPG GSLSALLRSK WGPLKDNEQT IGFYTKQILE CC GLKYLHDNQI VHRDIKGDNV LINTYSGVLK ISDFGTSKRL AGINPCTETF TGTLQYMAPE CC IIDKGPRGYG KAADIWSLGC TIIEMATGKP PFYELGEPQA AMFKVGMFKV HPEIPESMSA CC EAKAFILKCF EPDPDKRACA NDLLVDEFLK V CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES RSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAI CC ATOM -----------LLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAI CC *************************************** CC SEQRES KEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVP CC ATOM KEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVP CC ************************************************** CC SEQRES GGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDN CC ATOM GGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDN CC ************************************************** CC SEQRES VLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGY CC ATOM VLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGY CC ************************************************** CC SEQRES GKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMS CC ATOM GKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMS CC ************************************************** CC SEQRES AEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKL CC ATOM AEAKAFILKCFEPDPDKRACANDLLVDEFLKV----------- CC ******************************** SQ SEQUENCE 293 AA; MW; CN; RSTEEGDCES DLLEYDYEYD ENGDRVVLGK GTYGIVYAGR DLSNQVRIAI KEIPERDSRY SQPLHEEIAL HKHLKHKNIV QYLGSFSENG FIKIFMEQVP GGSLSALLRS KWGPLKDNEQ TIGFYTKQIL EGLKYLHDNQ IVHRDIKGDN VLINTYSGVL KISDFGTSKR LAGINPCTET FTGTLQYMAP EIIDKGPRGY GKAADIWSLG CTIIEMATGK PPFYELGEPQ AAMFKVGMFK VHPEIPESMS AEAKAFILKC FEPDPDKRAC ANDLLVDEFL KVSSKKKKTQ PKL // ID 5VILB STANDARD; PRT; 293 AA. DT CONVERTED FROM PDB (SEQRES) 5VIL DE Mitogen-activated protein kinase kinase kinase 5 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.640 CC R-Factor 0.182 FT #SUB 18 676 GLU B 111 769 LYS A Protein S 2 FT #SUB 42 700 LEU B 118 776 ASN A Protein B 3 FT #SUB 42 700 LEU B 121 779 THR A Protein B 1 FT #SUB 43 701 SER B 120 778 GLN A Protein A 8 FT #SUB 43 701 SER B 121 779 THR A Protein B 5 FT #SUB 44 702 ASN B 121 779 THR A Protein B 3 FT #SUB 44 702 ASN B 124 782 PHE A Protein S 7 FT #SUB 44 702 ASN B 125 783 TYR A Protein B 4 FT #SUB 45 703 GLN B 112 770 TRP A Protein S 5 FT #SUB 45 703 GLN B 118 776 ASN A Protein S 2 FT #SUB 45 703 GLN B 121 779 THR A Protein S 3 FT #SUB 46 704 VAL B 125 783 TYR A Protein S 1 FT #SUB 46 704 VAL B 155 813 THR A Protein A 3 FT #SUB 46 704 VAL B 156 814 TYR A Protein S 2 FT #SUB 46 704 VAL B 158 816 GLY A Protein S 2 FT #SUB 47 705 ARG B 111 769 LYS A Protein S 2 FT #SUB 47 705 ARG B 155 813 THR A Protein A 7 FT #SUB 47 705 ARG B 156 814 TYR A Protein S 7 FT #SUB 98 756 GLN B 156 814 TYR A Protein A 3 FT #SUB 100 758 PRO B 100 758 PRO A Protein S 1 FT #SUB 100 758 PRO B 156 814 TYR A Protein A 12 FT #SUB 111 769 LYS B 18 676 GLU A Protein S 1 FT #SUB 111 769 LYS B 47 705 ARG A Protein S 1 FT #SUB 112 770 TRP B 45 703 GLN A Protein S 7 FT #SUB 118 776 ASN B 42 700 LEU A Protein S 3 FT #SUB 118 776 ASN B 45 703 GLN A Protein S 1 FT #SUB 120 778 GLN B 14 672 GLU A Protein S 1 FT #SUB 120 778 GLN B 43 701 SER A Protein A 8 FT #SUB 121 779 THR B 42 700 LEU A Protein S 1 FT #SUB 121 779 THR B 43 701 SER A Protein A 5 FT #SUB 121 779 THR B 44 702 ASN A Protein S 3 FT #SUB 121 779 THR B 45 703 GLN A Protein S 2 FT #SUB 124 782 PHE B 44 702 ASN A Protein S 5 FT #SUB 125 783 TYR B 44 702 ASN A Protein S 4 FT #SUB 125 783 TYR B 46 704 VAL A Protein S 1 FT #SUB 155 813 THR B 46 704 VAL A Protein B 3 FT #SUB 155 813 THR B 47 705 ARG A Protein A 8 FT #SUB 156 814 TYR B 46 704 VAL A Protein B 2 FT #SUB 156 814 TYR B 47 705 ARG A Protein S 7 FT #SUB 156 814 TYR B 98 756 GLN A Protein S 2 FT #SUB 156 814 TYR B 100 758 PRO A Protein S 13 FT #SUB 158 816 GLY B 46 704 VAL A Protein B 2 FT #HET 18 676 GLU B 5 1003 DMS B S 10 FT #HET 28 686 LEU B 3 1001 9E1 B A 16 FT #HET 29 687 GLY B 3 1001 9E1 B B 8 FT #HET 30 688 LYS B 3 1001 9E1 B B 7 FT #HET 31 689 GLY B 3 1001 9E1 B B 4 FT #HET 36 694 VAL B 3 1001 9E1 B S 11 FT #HET 40 698 ARG B 5 1003 DMS B S 9 FT #HET 45 703 GLN B 5 1003 DMS B A 13 FT #HET 47 705 ARG B 5 1003 DMS B S 10 FT #HET 49 707 ALA B 3 1001 9E1 B S 4 FT #HET 51 709 LYS B 3 1001 9E1 B S 5 FT #HET 80 738 VAL B 3 1001 9E1 B S 4 FT #HET 96 754 MET B 3 1001 9E1 B S 6 FT #HET 97 755 GLU B 3 1001 9E1 B B 6 FT #HET 98 756 GLN B 3 1001 9E1 B A 17 FT #HET 99 757 VAL B 3 1001 9E1 B A 19 FT #HET 100 758 PRO B 3 1001 9E1 B B 4 FT #HET 101 759 GLY B 3 1001 9E1 B B 3 FT #HET 101 759 GLY B 6 1004 DMS B B 6 FT #HET 102 760 GLY B 3 1001 9E1 B B 9 FT #HET 103 761 SER B 3 1001 9E1 B A 4 FT #HET 107 765 LEU B 4 1002 DMS B S 1 FT #HET 111 769 LYS B 4 1002 DMS B S 5 FT #HET 112 770 TRP B 4 1002 DMS B S 14 FT #HET 149 807 ASP B 3 1001 9E1 B B 5 FT #HET 150 808 ASN B 3 1001 9E1 B A 9 FT #HET 152 810 LEU B 3 1001 9E1 B S 12 FT #HET 155 813 THR B 4 1002 DMS B S 4 FT #HET 156 814 TYR B 1 1001 9E1 A S 6 FT #HET 156 814 TYR B 2 1002 DMS A S 10 FT #HET 156 814 TYR B 6 1004 DMS B S 5 FT #HET 163 821 SER B 3 1001 9E1 B S 8 FT #HET 164 822 ASP B 3 1001 9E1 B A 12 FT DISORDER 1 11 FT DISORDER 283 293 CC SEQUENCE 271 AA (ATOM); CC LLEYDYEYDE NGDRVVLGKG TYGIVYAGRD LSNQVRIAIK EIPERDSRYS QPLHEEIALH CC KHLKHKNIVQ YLGSFSENGF IKIFMEQVPG GSLSALLRSK WGPLKDNEQT IGFYTKQILE CC GLKYLHDNQI VHRDIKGDNV LINTYSGVLK ISDFGTSKRL AGINPCTETF TGTLQYMAPE CC IIDKGPRGYG KAADIWSLGC TIIEMATGKP PFYELGEPQA AMFKVGMFKV HPEIPESMSA CC EAKAFILKCF EPDPDKRACA NDLLVDEFLK V CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES RSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAI CC ATOM -----------LLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAI CC *************************************** CC SEQRES KEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVP CC ATOM KEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVP CC ************************************************** CC SEQRES GGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDN CC ATOM GGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDN CC ************************************************** CC SEQRES VLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGY CC ATOM VLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGY CC ************************************************** CC SEQRES GKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMS CC ATOM GKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMS CC ************************************************** CC SEQRES AEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKL CC ATOM AEAKAFILKCFEPDPDKRACANDLLVDEFLKV----------- CC ******************************** SQ SEQUENCE 293 AA; MW; CN; RSTEEGDCES DLLEYDYEYD ENGDRVVLGK GTYGIVYAGR DLSNQVRIAI KEIPERDSRY SQPLHEEIAL HKHLKHKNIV QYLGSFSENG FIKIFMEQVP GGSLSALLRS KWGPLKDNEQ TIGFYTKQIL EGLKYLHDNQ IVHRDIKGDN VLINTYSGVL KISDFGTSKR LAGINPCTET FTGTLQYMAP EIIDKGPRGY GKAADIWSLG CTIIEMATGK PPFYELGEPQ AAMFKVGMFK VHPEIPESMS AEAKAFILKC FEPDPDKRAC ANDLLVDEFL KVSSKKKKTQ PKL // ID 5VILC STANDARD; PRT; 293 AA. DT CONVERTED FROM PDB (SEQRES) 5VIL DE Mitogen-activated protein kinase kinase kinase 5 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.640 CC R-Factor 0.182 FT #SUB 264 922 ASP C 267 925 LYS A Protein S 2 FT #SUB 266 924 ASP C 267 925 LYS A Protein S 1 FT #SUB 267 925 LYS C 267 925 LYS A Protein S 2 FT #SUB 14 672 GLU C 120 778 GLN D Protein S 1 FT #SUB 42 700 LEU C 118 776 ASN D Protein B 3 FT #SUB 42 700 LEU C 121 779 THR D Protein B 1 FT #SUB 43 701 SER C 120 778 GLN D Protein A 9 FT #SUB 43 701 SER C 121 779 THR D Protein B 5 FT #SUB 44 702 ASN C 121 779 THR D Protein B 3 FT #SUB 44 702 ASN C 124 782 PHE D Protein S 7 FT #SUB 44 702 ASN C 125 783 TYR D Protein B 4 FT #SUB 45 703 GLN C 112 770 TRP D Protein S 5 FT #SUB 45 703 GLN C 118 776 ASN D Protein S 2 FT #SUB 45 703 GLN C 121 779 THR D Protein S 4 FT #SUB 46 704 VAL C 125 783 TYR D Protein S 1 FT #SUB 46 704 VAL C 155 813 THR D Protein A 3 FT #SUB 46 704 VAL C 156 814 TYR D Protein S 2 FT #SUB 46 704 VAL C 157 815 SER D Protein S 1 FT #SUB 46 704 VAL C 158 816 GLY D Protein S 2 FT #SUB 47 705 ARG C 111 769 LYS D Protein S 4 FT #SUB 47 705 ARG C 155 813 THR D Protein A 7 FT #SUB 47 705 ARG C 156 814 TYR D Protein A 7 FT #SUB 98 756 GLN C 156 814 TYR D Protein A 5 FT #SUB 100 758 PRO C 100 758 PRO D Protein S 1 FT #SUB 100 758 PRO C 156 814 TYR D Protein A 13 FT #SUB 111 769 LYS C 18 676 GLU D Protein S 1 FT #SUB 112 770 TRP C 45 703 GLN D Protein S 5 FT #SUB 118 776 ASN C 42 700 LEU D Protein S 3 FT #SUB 118 776 ASN C 45 703 GLN D Protein S 1 FT #SUB 120 778 GLN C 14 672 GLU D Protein S 1 FT #SUB 120 778 GLN C 43 701 SER D Protein A 7 FT #SUB 121 779 THR C 42 700 LEU D Protein S 1 FT #SUB 121 779 THR C 43 701 SER D Protein A 5 FT #SUB 121 779 THR C 44 702 ASN D Protein S 3 FT #SUB 121 779 THR C 45 703 GLN D Protein S 3 FT #SUB 124 782 PHE C 44 702 ASN D Protein S 6 FT #SUB 125 783 TYR C 44 702 ASN D Protein S 4 FT #SUB 125 783 TYR C 46 704 VAL D Protein S 1 FT #SUB 155 813 THR C 46 704 VAL D Protein B 3 FT #SUB 155 813 THR C 47 705 ARG D Protein A 8 FT #SUB 156 814 TYR C 46 704 VAL D Protein B 2 FT #SUB 156 814 TYR C 47 705 ARG D Protein S 7 FT #SUB 156 814 TYR C 98 756 GLN D Protein S 3 FT #SUB 156 814 TYR C 100 758 PRO D Protein S 13 FT #SUB 157 815 SER C 46 704 VAL D Protein B 1 FT #SUB 158 816 GLY C 46 704 VAL D Protein B 2 FT #HET 28 686 LEU C 7 4000 9E1 C A 11 FT #HET 29 687 GLY C 7 4000 9E1 C B 4 FT #HET 30 688 LYS C 7 4000 9E1 C B 9 FT #HET 31 689 GLY C 7 4000 9E1 C B 4 FT #HET 36 694 VAL C 7 4000 9E1 C S 10 FT #HET 49 707 ALA C 7 4000 9E1 C S 4 FT #HET 51 709 LYS C 7 4000 9E1 C S 5 FT #HET 80 738 VAL C 7 4000 9E1 C S 3 FT #HET 96 754 MET C 7 4000 9E1 C S 6 FT #HET 97 755 GLU C 7 4000 9E1 C B 6 FT #HET 98 756 GLN C 7 4000 9E1 C A 11 FT #HET 99 757 VAL C 7 4000 9E1 C A 18 FT #HET 100 758 PRO C 7 4000 9E1 C B 4 FT #HET 101 759 GLY C 7 4000 9E1 C B 3 FT #HET 102 760 GLY C 7 4000 9E1 C B 9 FT #HET 103 761 SER C 7 4000 9E1 C A 5 FT #HET 149 807 ASP C 7 4000 9E1 C B 5 FT #HET 150 808 ASN C 7 4000 9E1 C A 8 FT #HET 152 810 LEU C 7 4000 9E1 C S 14 FT #HET 156 814 TYR C 8 4000 9E1 D S 8 FT #HET 163 821 SER C 7 4000 9E1 C S 3 FT #HET 164 822 ASP C 7 4000 9E1 C A 19 FT DISORDER 1 11 FT DISORDER 283 293 CC SEQUENCE 271 AA (ATOM); CC LLEYDYEYDE NGDRVVLGKG TYGIVYAGRD LSNQVRIAIK EIPERDSRYS QPLHEEIALH CC KHLKHKNIVQ YLGSFSENGF IKIFMEQVPG GSLSALLRSK WGPLKDNEQT IGFYTKQILE CC GLKYLHDNQI VHRDIKGDNV LINTYSGVLK ISDFGTSKRL AGINPCTETF TGTLQYMAPE CC IIDKGPRGYG KAADIWSLGC TIIEMATGKP PFYELGEPQA AMFKVGMFKV HPEIPESMSA CC EAKAFILKCF EPDPDKRACA NDLLVDEFLK V CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES RSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAI CC ATOM -----------LLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAI CC *************************************** CC SEQRES KEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVP CC ATOM KEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVP CC ************************************************** CC SEQRES GGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDN CC ATOM GGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDN CC ************************************************** CC SEQRES VLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGY CC ATOM VLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGY CC ************************************************** CC SEQRES GKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMS CC ATOM GKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMS CC ************************************************** CC SEQRES AEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKL CC ATOM AEAKAFILKCFEPDPDKRACANDLLVDEFLKV----------- CC ******************************** SQ SEQUENCE 293 AA; MW; CN; RSTEEGDCES DLLEYDYEYD ENGDRVVLGK GTYGIVYAGR DLSNQVRIAI KEIPERDSRY SQPLHEEIAL HKHLKHKNIV QYLGSFSENG FIKIFMEQVP GGSLSALLRS KWGPLKDNEQ TIGFYTKQIL EGLKYLHDNQ IVHRDIKGDN VLINTYSGVL KISDFGTSKR LAGINPCTET FTGTLQYMAP EIIDKGPRGY GKAADIWSLG CTIIEMATGK PPFYELGEPQ AAMFKVGMFK VHPEIPESMS AEAKAFILKC FEPDPDKRAC ANDLLVDEFL KVSSKKKKTQ PKL // ID 5VILD STANDARD; PRT; 293 AA. DT CONVERTED FROM PDB (SEQRES) 5VIL DE Mitogen-activated protein kinase kinase kinase 5 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.640 CC R-Factor 0.182 FT #SUB 14 672 GLU D 120 778 GLN C Protein S 1 FT #SUB 18 676 GLU D 111 769 LYS C Protein S 1 FT #SUB 42 700 LEU D 118 776 ASN C Protein B 3 FT #SUB 42 700 LEU D 121 779 THR C Protein B 1 FT #SUB 43 701 SER D 120 778 GLN C Protein A 7 FT #SUB 43 701 SER D 121 779 THR C Protein B 5 FT #SUB 44 702 ASN D 121 779 THR C Protein B 3 FT #SUB 44 702 ASN D 124 782 PHE C Protein S 6 FT #SUB 44 702 ASN D 125 783 TYR C Protein B 4 FT #SUB 45 703 GLN D 112 770 TRP C Protein S 5 FT #SUB 45 703 GLN D 118 776 ASN C Protein S 1 FT #SUB 45 703 GLN D 121 779 THR C Protein S 3 FT #SUB 46 704 VAL D 125 783 TYR C Protein S 1 FT #SUB 46 704 VAL D 155 813 THR C Protein A 3 FT #SUB 46 704 VAL D 156 814 TYR C Protein S 2 FT #SUB 46 704 VAL D 157 815 SER C Protein S 1 FT #SUB 46 704 VAL D 158 816 GLY C Protein S 2 FT #SUB 47 705 ARG D 155 813 THR C Protein A 8 FT #SUB 47 705 ARG D 156 814 TYR C Protein S 7 FT #SUB 98 756 GLN D 156 814 TYR C Protein A 3 FT #SUB 100 758 PRO D 100 758 PRO C Protein S 1 FT #SUB 100 758 PRO D 156 814 TYR C Protein A 13 FT #SUB 111 769 LYS D 47 705 ARG C Protein S 4 FT #SUB 112 770 TRP D 45 703 GLN C Protein S 5 FT #SUB 118 776 ASN D 42 700 LEU C Protein S 3 FT #SUB 118 776 ASN D 45 703 GLN C Protein S 2 FT #SUB 120 778 GLN D 14 672 GLU C Protein S 1 FT #SUB 120 778 GLN D 43 701 SER C Protein A 9 FT #SUB 121 779 THR D 42 700 LEU C Protein S 1 FT #SUB 121 779 THR D 43 701 SER C Protein A 5 FT #SUB 121 779 THR D 44 702 ASN C Protein S 3 FT #SUB 121 779 THR D 45 703 GLN C Protein S 4 FT #SUB 124 782 PHE D 44 702 ASN C Protein S 7 FT #SUB 125 783 TYR D 44 702 ASN C Protein S 4 FT #SUB 125 783 TYR D 46 704 VAL C Protein S 1 FT #SUB 155 813 THR D 46 704 VAL C Protein B 3 FT #SUB 155 813 THR D 47 705 ARG C Protein A 7 FT #SUB 156 814 TYR D 46 704 VAL C Protein B 2 FT #SUB 156 814 TYR D 47 705 ARG C Protein A 7 FT #SUB 156 814 TYR D 98 756 GLN C Protein S 5 FT #SUB 156 814 TYR D 100 758 PRO C Protein S 13 FT #SUB 157 815 SER D 46 704 VAL C Protein B 1 FT #SUB 158 816 GLY D 46 704 VAL C Protein B 2 FT #HET 28 686 LEU D 8 4000 9E1 D A 14 FT #HET 29 687 GLY D 8 4000 9E1 D B 12 FT #HET 30 688 LYS D 8 4000 9E1 D B 5 FT #HET 31 689 GLY D 8 4000 9E1 D B 4 FT #HET 36 694 VAL D 8 4000 9E1 D S 8 FT #HET 49 707 ALA D 8 4000 9E1 D S 4 FT #HET 51 709 LYS D 8 4000 9E1 D S 3 FT #HET 80 738 VAL D 8 4000 9E1 D S 5 FT #HET 96 754 MET D 8 4000 9E1 D S 7 FT #HET 97 755 GLU D 8 4000 9E1 D B 7 FT #HET 98 756 GLN D 8 4000 9E1 D A 18 FT #HET 99 757 VAL D 8 4000 9E1 D A 17 FT #HET 100 758 PRO D 8 4000 9E1 D B 4 FT #HET 101 759 GLY D 8 4000 9E1 D B 3 FT #HET 102 760 GLY D 8 4000 9E1 D B 8 FT #HET 103 761 SER D 8 4000 9E1 D A 4 FT #HET 149 807 ASP D 8 4000 9E1 D B 5 FT #HET 150 808 ASN D 8 4000 9E1 D A 3 FT #HET 152 810 LEU D 8 4000 9E1 D S 13 FT #HET 156 814 TYR D 7 4000 9E1 C S 6 FT #HET 163 821 SER D 8 4000 9E1 D S 5 FT #HET 164 822 ASP D 8 4000 9E1 D A 14 FT DISORDER 1 11 FT DISORDER 283 293 CC SEQUENCE 271 AA (ATOM); CC LLEYDYEYDE NGDRVVLGKG TYGIVYAGRD LSNQVRIAIK EIPERDSRYS QPLHEEIALH CC KHLKHKNIVQ YLGSFSENGF IKIFMEQVPG GSLSALLRSK WGPLKDNEQT IGFYTKQILE CC GLKYLHDNQI VHRDIKGDNV LINTYSGVLK ISDFGTSKRL AGINPCTETF TGTLQYMAPE CC IIDKGPRGYG KAADIWSLGC TIIEMATGKP PFYELGEPQA AMFKVGMFKV HPEIPESMSA CC EAKAFILKCF EPDPDKRACA NDLLVDEFLK V CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES RSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAI CC ATOM -----------LLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAI CC *************************************** CC SEQRES KEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVP CC ATOM KEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVP CC ************************************************** CC SEQRES GGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDN CC ATOM GGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDN CC ************************************************** CC SEQRES VLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGY CC ATOM VLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGY CC ************************************************** CC SEQRES GKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMS CC ATOM GKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMS CC ************************************************** CC SEQRES AEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKL CC ATOM AEAKAFILKCFEPDPDKRACANDLLVDEFLKV----------- CC ******************************** SQ SEQUENCE 293 AA; MW; CN; RSTEEGDCES DLLEYDYEYD ENGDRVVLGK GTYGIVYAGR DLSNQVRIAI KEIPERDSRY SQPLHEEIAL HKHLKHKNIV QYLGSFSENG FIKIFMEQVP GGSLSALLRS KWGPLKDNEQ TIGFYTKQIL EGLKYLHDNQ IVHRDIKGDN VLINTYSGVL KISDFGTSKR LAGINPCTET FTGTLQYMAP EIIDKGPRGY GKAADIWSLG CTIIEMATGK PPFYELGEPQ AAMFKVGMFK VHPEIPESMS AEAKAFILKC FEPDPDKRAC ANDLLVDEFL KVSSKKKKTQ PKL //