ID	5VEUA	STANDARD;	PRT;	480	AA.
DT	CONVERTED FROM PDB (SEQRES) 5VEU
DE	Cytochrome P450 3A5
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.910
CC	R-Factor	0.216
FT	#SUB	309	 330 	LYS	A	384	 405 	PRO	C	Protein	S	4
FT	#SUB	309	 330 	LYS	A	385	 406 	LYS	C	Protein	S	4
FT	#SUB	312	 333 	LYS	A	388	 409 	THR	C	Protein	S	1
FT	#SUB	313	 334 	GLU	A	389	 410 	GLU	C	Protein	S	4
FT	#SUB	317	 338 	VAL	A	389	 410 	GLU	C	Protein	S	1
FT	#SUB	331	 352 	GLN	A	389	 410 	GLU	C	Protein	B	1
FT	#SUB	332	 353 	MET	A	389	 410 	GLU	C	Protein	B	1
FT	#SUB	333	 354 	GLU	A	389	 410 	GLU	C	Protein	B	2
FT	#SUB	385	 406 	LYS	A	46	  67 	LYS	C	Protein	B	2
FT	#SUB	386	 407 	TYR	A	46	  67 	LYS	C	Protein	B	2
FT	#SUB	388	 409 	THR	A	46	  67 	LYS	C	Protein	S	4
FT	#SUB	388	 409 	THR	A	47	  68 	TYR	C	Protein	S	2
FT	#SUB	396	 417 	GLU	A	45	  66 	LYS	C	Protein	B	4
FT	#SUB	397	 418 	ARG	A	45	  66 	LYS	C	Protein	B	5
FT	#SUB	399	 420 	SER	A	45	  66 	LYS	C	Protein	S	1
FT	#SUB	401	 422 	LYS	A	391	 412 	GLU	C	Protein	S	2
FT	#SUB	404	 425 	SER	A	38	  59 	LYS	C	Protein	S	1
FT	#SUB	404	 425 	SER	A	42	  63 	GLU	C	Protein	S	6
FT	#SUB	404	 425 	SER	A	45	  66 	LYS	C	Protein	S	1
FT	#SUB	179	 200 	GLN	A	234	 255 	ARG	D	Protein	S	2
FT	#SUB	184	 205 	GLU	A	230	 251 	LYS	D	Protein	S	2
FT	#SUB	188	 209 	LYS	A	226	 247 	ASN	D	Protein	S	1
FT	#SUB	197	 218 	PRO	A	215	 236 	LEU	D	Protein	B	2
FT	#SUB	198	 219 	LEU	A	215	 236 	LEU	D	Protein	B	2
FT	#SUB	212	 233 	PHE	A	215	 236 	LEU	D	Protein	S	2
FT	#SUB	214	 235 	ALA	A	197	 218 	PRO	D	Protein	B	2
FT	#SUB	215	 236 	LEU	A	197	 218 	PRO	D	Protein	S	2
FT	#SUB	215	 236 	LEU	A	198	 219 	LEU	D	Protein	S	2
FT	#SUB	215	 236 	LEU	A	212	 233 	PHE	D	Protein	S	2
FT	#SUB	217	 238 	VAL	A	217	 238 	VAL	D	Protein	S	1
FT	#SUB	223	 244 	ASP	A	223	 244 	ASP	D	Protein	A	3
FT	#SUB	223	 244 	ASP	A	226	 247 	ASN	D	Protein	S	3
FT	#SUB	226	 247 	ASN	A	188	 209 	LYS	D	Protein	S	2
FT	#SUB	226	 247 	ASN	A	223	 244 	ASP	D	Protein	S	6
FT	#SUB	230	 251 	LYS	A	184	 205 	GLU	D	Protein	S	3
FT	#SUB	234	 255 	ARG	A	179	 200 	GLN	D	Protein	S	4
FT	#SUB	207	 228 	PHE	A	210	 231 	PRO	E	Protein	S	5
FT	#SUB	207	 228 	PHE	A	211	 232 	VAL	E	Protein	S	5
FT	#SUB	207	 228 	PHE	A	214	 235 	ALA	E	Protein	S	2
FT	#SUB	211	 232 	VAL	A	207	 228 	PHE	E	Protein	A	6
FT	#SUB	214	 235 	ALA	A	207	 228 	PHE	E	Protein	S	2
FT	#SUB	13	  34 	LYS	A	389	 410 	GLU	G	Protein	A	6
FT	#SUB	13	  34 	LYS	A	392	 413 	GLU	G	Protein	S	2
FT	#SUB	14	  35 	ARG	A	388	 409 	THR	G	Protein	S	1
FT	#SUB	14	  35 	ARG	A	389	 410 	GLU	G	Protein	B	6
FT	#SUB	14	  35 	ARG	A	390	 411 	PRO	G	Protein	B	1
FT	#SUB	15	  36 	LEU	A	384	 405 	PRO	G	Protein	B	4
FT	#SUB	15	  36 	LEU	A	390	 411 	PRO	G	Protein	B	1
FT	#SUB	16	  37 	GLY	A	390	 411 	PRO	G	Protein	B	1
FT	#SUB	49	  70 	LYS	A	42	  63 	GLU	G	Protein	S	1
FT	#SUB	65	  86 	ASP	A	46	  67 	LYS	G	Protein	S	2
FT	#SUB	67	  88 	ASP	A	46	  67 	LYS	G	Protein	S	3
FT	#SUB	363	 384 	ASN	A	45	  66 	LYS	G	Protein	A	10
FT	#SUB	364	 385 	GLY	A	45	  66 	LYS	G	Protein	B	1
FT	#SUB	364	 385 	GLY	A	385	 406 	LYS	G	Protein	B	1
FT	#SUB	365	 386 	VAL	A	384	 405 	PRO	G	Protein	S	1
FT	#SUB	366	 387 	PHE	A	385	 406 	LYS	G	Protein	S	3
FT	#SUB	23	  44 	LEU	A	30	  51 	LEU	I	Protein	S	1
FT	#SUB	24	  45 	PRO	A	195	 216 	LEU	I	Protein	S	5
FT	#SUB	25	  46 	LEU	A	201	 222 	SER	I	Protein	S	2
FT	#SUB	25	  46 	LEU	A	204	 225 	LEU	I	Protein	S	1
FT	#SUB	26	  47 	LEU	A	26	  47 	LEU	I	Protein	S	1
FT	#SUB	26	  47 	LEU	A	204	 225 	LEU	I	Protein	S	1
FT	#SUB	30	  51 	LEU	A	23	  44 	LEU	I	Protein	S	1
FT	#SUB	30	  51 	LEU	A	26	  47 	LEU	I	Protein	S	2
FT	#SUB	33	  54 	ARG	A	23	  44 	LEU	I	Protein	S	3
FT	#SUB	33	  54 	ARG	A	24	  45 	PRO	I	Protein	S	3
FT	#SUB	195	 216 	LEU	A	25	  46 	LEU	I	Protein	S	1
FT	#SUB	200	 221 	LEU	A	25	  46 	LEU	I	Protein	S	1
FT	#SUB	204	 225 	LEU	A	204	 225 	LEU	I	Protein	S	1
FT	#SUB	204	 225 	LEU	A	205	 226 	PHE	I	Protein	S	2
FT	#SUB	205	 226 	PHE	A	205	 226 	PHE	I	Protein	S	1
FT	#HET	84	 105 	ARG	A	1	601 	HEM	A	S	9
FT	#HET	84	 105 	ARG	A	2	602 	RIT	A	S	1
FT	#HET	85	 106 	ARG	A	2	602 	RIT	A	S	3
FT	#HET	97	 118 	ILE	A	1	601 	HEM	A	A	5
FT	#HET	98	 119 	SER	A	1	601 	HEM	A	A	2
FT	#HET	98	 119 	SER	A	2	602 	RIT	A	A	4
FT	#HET	99	 120 	LEU	A	2	602 	RIT	A	S	2
FT	#HET	105	 126 	TRP	A	1	601 	HEM	A	S	5
FT	#HET	109	 130 	ARG	A	1	601 	HEM	A	S	4
FT	#HET	163	 184 	ILE	A	1	601 	HEM	A	S	1
FT	#HET	189	 210 	PHE	A	2	602 	RIT	A	A	8
FT	#HET	192	 213 	PHE	A	2	602 	RIT	A	A	8
FT	#HET	194	 215 	PHE	A	2	602 	RIT	A	S	2
FT	#HET	199	 220 	PHE	A	2	602 	RIT	A	S	1
FT	#HET	219	 240 	LEU	A	2	602 	RIT	A	B	1
FT	#HET	220	 241 	PHE	A	2	602 	RIT	A	S	7
FT	#HET	280	 301 	ILE	A	1	601 	HEM	A	S	1
FT	#HET	280	 301 	ILE	A	2	602 	RIT	A	S	2
FT	#HET	281	 302 	PHE	A	1	601 	HEM	A	S	4
FT	#HET	283	 304 	PHE	A	2	602 	RIT	A	S	10
FT	#HET	284	 305 	ALA	A	1	601 	HEM	A	A	7
FT	#HET	284	 305 	ALA	A	2	602 	RIT	A	S	1
FT	#HET	285	 306 	GLY	A	1	601 	HEM	A	B	2
FT	#HET	288	 309 	THR	A	1	601 	HEM	A	S	8
FT	#HET	288	 309 	THR	A	2	602 	RIT	A	S	2
FT	#HET	292	 313 	VAL	A	1	601 	HEM	A	S	1
FT	#HET	343	 364 	LEU	A	1	601 	HEM	A	S	1
FT	#HET	348	 369 	VAL	A	1	601 	HEM	A	S	1
FT	#HET	349	 370 	ALA	A	1	601 	HEM	A	S	1
FT	#HET	349	 370 	ALA	A	2	602 	RIT	A	S	2
FT	#HET	352	 373 	LEU	A	1	601 	HEM	A	S	3
FT	#HET	354	 375 	ARG	A	1	601 	HEM	A	S	9
FT	#HET	412	 433 	PRO	A	1	601 	HEM	A	B	4
FT	#HET	413	 434 	PHE	A	1	601 	HEM	A	A	13
FT	#HET	414	 435 	GLY	A	1	601 	HEM	A	B	5
FT	#HET	415	 436 	THR	A	1	601 	HEM	A	B	1
FT	#HET	418	 439 	ARG	A	1	601 	HEM	A	A	12
FT	#HET	419	 440 	ASN	A	1	601 	HEM	A	B	4
FT	#HET	420	 441 	CYS	A	1	601 	HEM	A	A	24
FT	#HET	421	 442 	ILE	A	1	601 	HEM	A	A	5
FT	#HET	425	 446 	PHE	A	1	601 	HEM	A	S	2
FT	#HET	426	 447 	ALA	A	1	601 	HEM	A	S	2
FT	#HET	430	 451 	MET	A	1	601 	HEM	A	S	1
FT	#HET	459	 480 	GLY	A	2	602 	RIT	A	B	3
FT	#HET	460	 481 	LEU	A	2	602 	RIT	A	S	1
FT	DISORDER	1	5
FT	DISORDER	261	267
FT	DISORDER	475	480
CC	SEQUENCE	462 AA (ATOM);
CC	TRTHGLFKRL GIPGPTPLPL LGNVLSYRQG LWKFDTECYK KYGKMWGTYE GQLPVLAITD
CC	PDVIRTVLVK ECYSVFTNRR SLGPVGFMKS AISLAEDEEW KRIRSLLSPT FTSGKLKEMF
CC	PIIAQYGDVL VRNLRREAEK GKPVTLKDIF GAYSMDVITG TSFGVNIDSL NNPQDPFVES
CC	TKKFLKFGFL DPLFLSIILF PFLTPVFEAL NVSLFPKDTI NFLSKSVNRM KKSRLNDKQK
CC	HRLDFLQLMI DSQNSALSDL ELAAQSIIFI FAGYETTSSV LSFTLYELAT HPDVQQKLQK
CC	EIDAVLPNKA PPTYDAVVQM EYLDMVVNET LRLFPVAIRL ERTCKKDVEI NGVFIPKGSM
CC	VVIPTYALHH DPKYWTEPEE FRPERFSKKK DSIDPYIYTP FGTGPRNCIG MRFALMNMKL
CC	ALIRVLQNFS FKPCKETQIP LKLDTQGLLQ PEKPIVLKVD SR
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MALYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	ATOM   -----TRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	            *********************************************
CC	SEQRES WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	ATOM   WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	       **************************************************
CC	SEQRES EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	ATOM   EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	       **************************************************
CC	SEQRES LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	ATOM   LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	       **************************************************
CC	SEQRES SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	ATOM   SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	       **************************************************
CC	SEQRES LQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	ATOM   LQLMIDSQNS-------ALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	       **********       *********************************
CC	SEQRES ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	ATOM   ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	       **************************************************
CC	SEQRES RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK
CC	ATOM   RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK
CC	       **************************************************
CC	SEQRES KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	ATOM   KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	       **************************************************
CC	SEQRES IPLKLDTQGLLQPEKPIVLKVDSRDGHHHH
CC	ATOM   IPLKLDTQGLLQPEKPIVLKVDSR------
CC	       ************************      
SQ	SEQUENCE	480 AA;      MW;         CN;
	MALYGTRTHG LFKRLGIPGP TPLPLLGNVL SYRQGLWKFD TECYKKYGKM WGTYEGQLPV
	LAITDPDVIR TVLVKECYSV FTNRRSLGPV GFMKSAISLA EDEEWKRIRS LLSPTFTSGK
	LKEMFPIIAQ YGDVLVRNLR REAEKGKPVT LKDIFGAYSM DVITGTSFGV NIDSLNNPQD
	PFVESTKKFL KFGFLDPLFL SIILFPFLTP VFEALNVSLF PKDTINFLSK SVNRMKKSRL
	NDKQKHRLDF LQLMIDSQNS KETESHKALS DLELAAQSII FIFAGYETTS SVLSFTLYEL
	ATHPDVQQKL QKEIDAVLPN KAPPTYDAVV QMEYLDMVVN ETLRLFPVAI RLERTCKKDV
	EINGVFIPKG SMVVIPTYAL HHDPKYWTEP EEFRPERFSK KKDSIDPYIY TPFGTGPRNC
	IGMRFALMNM KLALIRVLQN FSFKPCKETQ IPLKLDTQGL LQPEKPIVLK VDSRDGHHHH
//
ID	5VEUB	STANDARD;	PRT;	480	AA.
DT	CONVERTED FROM PDB (SEQRES) 5VEU
DE	Cytochrome P450 3A5
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.910
CC	R-Factor	0.216
FT	#SUB	119	 140 	GLY	B	67	  88 	ASP	E	Protein	B	5
FT	#SUB	122	 143 	LYS	B	49	  70 	LYS	E	Protein	S	1
FT	#SUB	122	 143 	LYS	B	65	  86 	ASP	E	Protein	S	1
FT	#SUB	123	 144 	GLU	B	70	  91 	ARG	E	Protein	S	1
FT	#SUB	123	 144 	GLU	B	71	  92 	THR	E	Protein	S	1
FT	#SUB	184	 205 	GLU	B	230	 251 	LYS	F	Protein	S	2
FT	#SUB	188	 209 	LYS	B	226	 247 	ASN	F	Protein	S	1
FT	#SUB	197	 218 	PRO	B	215	 236 	LEU	F	Protein	B	1
FT	#SUB	198	 219 	LEU	B	215	 236 	LEU	F	Protein	B	2
FT	#SUB	212	 233 	PHE	B	215	 236 	LEU	F	Protein	S	2
FT	#SUB	214	 235 	ALA	B	197	 218 	PRO	F	Protein	B	2
FT	#SUB	215	 236 	LEU	B	197	 218 	PRO	F	Protein	S	1
FT	#SUB	215	 236 	LEU	B	201	 222 	SER	F	Protein	S	1
FT	#SUB	215	 236 	LEU	B	212	 233 	PHE	F	Protein	S	2
FT	#SUB	217	 238 	VAL	B	217	 238 	VAL	F	Protein	S	3
FT	#SUB	223	 244 	ASP	B	226	 247 	ASN	F	Protein	S	4
FT	#SUB	226	 247 	ASN	B	223	 244 	ASP	F	Protein	S	1
FT	#SUB	230	 251 	LYS	B	184	 205 	GLU	F	Protein	S	2
FT	#SUB	207	 228 	PHE	B	210	 231 	PRO	H	Protein	S	1
FT	#SUB	207	 228 	PHE	B	211	 232 	VAL	H	Protein	S	1
FT	#SUB	207	 228 	PHE	B	214	 235 	ALA	H	Protein	S	2
FT	#SUB	210	 231 	PRO	B	207	 228 	PHE	H	Protein	S	1
FT	#SUB	211	 232 	VAL	B	207	 228 	PHE	H	Protein	A	3
FT	#SUB	214	 235 	ALA	B	207	 228 	PHE	H	Protein	S	2
FT	#SUB	23	  44 	LEU	B	30	  51 	LEU	L	Protein	S	1
FT	#SUB	24	  45 	PRO	B	195	 216 	LEU	L	Protein	S	5
FT	#SUB	25	  46 	LEU	B	200	 221 	LEU	L	Protein	A	3
FT	#SUB	25	  46 	LEU	B	201	 222 	SER	L	Protein	S	1
FT	#SUB	26	  47 	LEU	B	204	 225 	LEU	L	Protein	S	2
FT	#SUB	30	  51 	LEU	B	26	  47 	LEU	L	Protein	S	1
FT	#SUB	33	  54 	ARG	B	24	  45 	PRO	L	Protein	S	2
FT	#SUB	195	 216 	LEU	B	24	  45 	PRO	L	Protein	S	1
FT	#SUB	195	 216 	LEU	B	25	  46 	LEU	L	Protein	S	2
FT	#SUB	200	 221 	LEU	B	25	  46 	LEU	L	Protein	S	1
FT	#SUB	200	 221 	LEU	B	205	 226 	PHE	L	Protein	S	1
FT	#SUB	204	 225 	LEU	B	204	 225 	LEU	L	Protein	S	1
FT	#SUB	205	 226 	PHE	B	205	 226 	PHE	L	Protein	S	1
FT	#HET	84	 105 	ARG	B	3	601 	HEM	B	S	9
FT	#HET	85	 106 	ARG	B	4	602 	RIT	B	S	8
FT	#HET	97	 118 	ILE	B	3	601 	HEM	B	A	4
FT	#HET	98	 119 	SER	B	3	601 	HEM	B	A	2
FT	#HET	98	 119 	SER	B	4	602 	RIT	B	S	1
FT	#HET	99	 120 	LEU	B	4	602 	RIT	B	S	1
FT	#HET	105	 126 	TRP	B	3	601 	HEM	B	S	6
FT	#HET	109	 130 	ARG	B	3	601 	HEM	B	S	5
FT	#HET	163	 184 	ILE	B	3	601 	HEM	B	S	1
FT	#HET	189	 210 	PHE	B	4	602 	RIT	B	S	9
FT	#HET	194	 215 	PHE	B	4	602 	RIT	B	S	4
FT	#HET	220	 241 	PHE	B	4	602 	RIT	B	S	5
FT	#HET	280	 301 	ILE	B	4	602 	RIT	B	S	2
FT	#HET	281	 302 	PHE	B	3	601 	HEM	B	A	2
FT	#HET	283	 304 	PHE	B	4	602 	RIT	B	S	12
FT	#HET	284	 305 	ALA	B	3	601 	HEM	B	A	5
FT	#HET	284	 305 	ALA	B	4	602 	RIT	B	S	3
FT	#HET	285	 306 	GLY	B	3	601 	HEM	B	B	2
FT	#HET	288	 309 	THR	B	3	601 	HEM	B	S	6
FT	#HET	288	 309 	THR	B	4	602 	RIT	B	S	2
FT	#HET	292	 313 	VAL	B	3	601 	HEM	B	S	1
FT	#HET	343	 364 	LEU	B	3	601 	HEM	B	S	1
FT	#HET	348	 369 	VAL	B	3	601 	HEM	B	S	4
FT	#HET	349	 370 	ALA	B	3	601 	HEM	B	S	1
FT	#HET	349	 370 	ALA	B	4	602 	RIT	B	S	2
FT	#HET	350	 371 	ILE	B	4	602 	RIT	B	S	1
FT	#HET	352	 373 	LEU	B	3	601 	HEM	B	S	5
FT	#HET	353	 374 	GLU	B	4	602 	RIT	B	S	3
FT	#HET	354	 375 	ARG	B	3	601 	HEM	B	S	8
FT	#HET	412	 433 	PRO	B	3	601 	HEM	B	B	6
FT	#HET	413	 434 	PHE	B	3	601 	HEM	B	A	17
FT	#HET	414	 435 	GLY	B	3	601 	HEM	B	B	2
FT	#HET	415	 436 	THR	B	3	601 	HEM	B	B	1
FT	#HET	418	 439 	ARG	B	3	601 	HEM	B	A	11
FT	#HET	419	 440 	ASN	B	3	601 	HEM	B	B	2
FT	#HET	420	 441 	CYS	B	3	601 	HEM	B	A	24
FT	#HET	421	 442 	ILE	B	3	601 	HEM	B	A	4
FT	#HET	422	 443 	GLY	B	3	601 	HEM	B	B	4
FT	#HET	425	 446 	PHE	B	3	601 	HEM	B	S	1
FT	#HET	426	 447 	ALA	B	3	601 	HEM	B	S	2
FT	#HET	430	 451 	MET	B	3	601 	HEM	B	S	1
FT	#HET	459	 480 	GLY	B	4	602 	RIT	B	B	5
FT	#HET	460	 481 	LEU	B	4	602 	RIT	B	B	1
FT	DISORDER	1	5
FT	DISORDER	261	267
FT	DISORDER	400	403
FT	DISORDER	475	480
CC	SEQUENCE	458 AA (ATOM);
CC	TRTHGLFKRL GIPGPTPLPL LGNVLSYRQG LWKFDTECYK KYGKMWGTYE GQLPVLAITD
CC	PDVIRTVLVK ECYSVFTNRR SLGPVGFMKS AISLAEDEEW KRIRSLLSPT FTSGKLKEMF
CC	PIIAQYGDVL VRNLRREAEK GKPVTLKDIF GAYSMDVITG TSFGVNIDSL NNPQDPFVES
CC	TKKFLKFGFL DPLFLSIILF PFLTPVFEAL NVSLFPKDTI NFLSKSVNRM KKSRLNDKQK
CC	HRLDFLQLMI DSQNSALSDL ELAAQSIIFI FAGYETTSSV LSFTLYELAT HPDVQQKLQK
CC	EIDAVLPNKA PPTYDAVVQM EYLDMVVNET LRLFPVAIRL ERTCKKDVEI NGVFIPKGSM
CC	VVIPTYALHH DPKYWTEPEE FRPERFSSID PYIYTPFGTG PRNCIGMRFA LMNMKLALIR
CC	VLQNFSFKPC KETQIPLKLD TQGLLQPEKP IVLKVDSR
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MALYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	ATOM   -----TRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	            *********************************************
CC	SEQRES WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	ATOM   WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	       **************************************************
CC	SEQRES EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	ATOM   EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	       **************************************************
CC	SEQRES LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	ATOM   LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	       **************************************************
CC	SEQRES SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	ATOM   SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	       **************************************************
CC	SEQRES LQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	ATOM   LQLMIDSQNS-------ALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	       **********       *********************************
CC	SEQRES ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	ATOM   ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	       **************************************************
CC	SEQRES RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK
CC	ATOM   RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-
CC	       ************************************************* 
CC	SEQRES KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	ATOM   ---SIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	          ***********************************************
CC	SEQRES IPLKLDTQGLLQPEKPIVLKVDSRDGHHHH
CC	ATOM   IPLKLDTQGLLQPEKPIVLKVDSR------
CC	       ************************      
SQ	SEQUENCE	480 AA;      MW;         CN;
	MALYGTRTHG LFKRLGIPGP TPLPLLGNVL SYRQGLWKFD TECYKKYGKM WGTYEGQLPV
	LAITDPDVIR TVLVKECYSV FTNRRSLGPV GFMKSAISLA EDEEWKRIRS LLSPTFTSGK
	LKEMFPIIAQ YGDVLVRNLR REAEKGKPVT LKDIFGAYSM DVITGTSFGV NIDSLNNPQD
	PFVESTKKFL KFGFLDPLFL SIILFPFLTP VFEALNVSLF PKDTINFLSK SVNRMKKSRL
	NDKQKHRLDF LQLMIDSQNS KETESHKALS DLELAAQSII FIFAGYETTS SVLSFTLYEL
	ATHPDVQQKL QKEIDAVLPN KAPPTYDAVV QMEYLDMVVN ETLRLFPVAI RLERTCKKDV
	EINGVFIPKG SMVVIPTYAL HHDPKYWTEP EEFRPERFSK KKDSIDPYIY TPFGTGPRNC
	IGMRFALMNM KLALIRVLQN FSFKPCKETQ IPLKLDTQGL LQPEKPIVLK VDSRDGHHHH
//
ID	5VEUC	STANDARD;	PRT;	480	AA.
DT	CONVERTED FROM PDB (SEQRES) 5VEU
DE	Cytochrome P450 3A5
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.910
CC	R-Factor	0.216
FT	#SUB	38	  59 	LYS	C	404	 425 	SER	A	Protein	S	1
FT	#SUB	42	  63 	GLU	C	404	 425 	SER	A	Protein	S	6
FT	#SUB	45	  66 	LYS	C	396	 417 	GLU	A	Protein	A	4
FT	#SUB	45	  66 	LYS	C	397	 418 	ARG	A	Protein	A	5
FT	#SUB	45	  66 	LYS	C	399	 420 	SER	A	Protein	S	1
FT	#SUB	45	  66 	LYS	C	404	 425 	SER	A	Protein	S	1
FT	#SUB	46	  67 	LYS	C	385	 406 	LYS	A	Protein	S	2
FT	#SUB	46	  67 	LYS	C	386	 407 	TYR	A	Protein	S	2
FT	#SUB	46	  67 	LYS	C	388	 409 	THR	A	Protein	A	4
FT	#SUB	47	  68 	TYR	C	388	 409 	THR	A	Protein	S	2
FT	#SUB	384	 405 	PRO	C	309	 330 	LYS	A	Protein	B	4
FT	#SUB	385	 406 	LYS	C	309	 330 	LYS	A	Protein	B	4
FT	#SUB	388	 409 	THR	C	312	 333 	LYS	A	Protein	S	1
FT	#SUB	389	 410 	GLU	C	313	 334 	GLU	A	Protein	S	4
FT	#SUB	389	 410 	GLU	C	317	 338 	VAL	A	Protein	S	1
FT	#SUB	389	 410 	GLU	C	331	 352 	GLN	A	Protein	S	1
FT	#SUB	389	 410 	GLU	C	332	 353 	MET	A	Protein	S	1
FT	#SUB	389	 410 	GLU	C	333	 354 	GLU	A	Protein	S	2
FT	#SUB	391	 412 	GLU	C	401	 422 	LYS	A	Protein	S	2
FT	#SUB	23	  44 	LEU	C	33	  54 	ARG	G	Protein	S	2
FT	#SUB	24	  45 	PRO	C	33	  54 	ARG	G	Protein	S	2
FT	#SUB	24	  45 	PRO	C	195	 216 	LEU	G	Protein	S	2
FT	#SUB	25	  46 	LEU	C	200	 221 	LEU	G	Protein	S	1
FT	#SUB	26	  47 	LEU	C	26	  47 	LEU	G	Protein	S	2
FT	#SUB	30	  51 	LEU	C	23	  44 	LEU	G	Protein	S	4
FT	#SUB	195	 216 	LEU	C	24	  45 	PRO	G	Protein	A	5
FT	#SUB	197	 218 	PRO	C	25	  46 	LEU	G	Protein	S	1
FT	#SUB	204	 225 	LEU	C	25	  46 	LEU	G	Protein	S	1
FT	#SUB	204	 225 	LEU	C	26	  47 	LEU	G	Protein	S	2
FT	#SUB	204	 225 	LEU	C	204	 225 	LEU	G	Protein	S	1
FT	#SUB	205	 226 	PHE	C	200	 221 	LEU	G	Protein	S	2
FT	#SUB	205	 226 	PHE	C	204	 225 	LEU	G	Protein	S	2
FT	#SUB	205	 226 	PHE	C	205	 226 	PHE	G	Protein	S	1
FT	#SUB	207	 228 	PHE	C	211	 232 	VAL	J	Protein	S	3
FT	#SUB	207	 228 	PHE	C	214	 235 	ALA	J	Protein	S	2
FT	#SUB	211	 232 	VAL	C	207	 228 	PHE	J	Protein	S	3
FT	#SUB	211	 232 	VAL	C	211	 232 	VAL	J	Protein	S	1
FT	#SUB	214	 235 	ALA	C	207	 228 	PHE	J	Protein	S	3
FT	#SUB	179	 200 	GLN	C	234	 255 	ARG	K	Protein	A	6
FT	#SUB	184	 205 	GLU	C	234	 255 	ARG	K	Protein	S	5
FT	#SUB	212	 233 	PHE	C	215	 236 	LEU	K	Protein	S	3
FT	#SUB	215	 236 	LEU	C	212	 233 	PHE	K	Protein	S	1
FT	#SUB	215	 236 	LEU	C	215	 236 	LEU	K	Protein	S	1
FT	#SUB	223	 244 	ASP	C	223	 244 	ASP	K	Protein	S	2
FT	#SUB	223	 244 	ASP	C	226	 247 	ASN	K	Protein	S	4
FT	#SUB	226	 247 	ASN	C	223	 244 	ASP	K	Protein	S	3
FT	#SUB	230	 251 	LYS	C	184	 205 	GLU	K	Protein	S	1
FT	#SUB	234	 255 	ARG	C	179	 200 	GLN	K	Protein	S	1
FT	#SUB	234	 255 	ARG	C	184	 205 	GLU	K	Protein	S	3
FT	#HET	84	 105 	ARG	C	5	601 	HEM	C	S	8
FT	#HET	97	 118 	ILE	C	5	601 	HEM	C	A	5
FT	#HET	98	 119 	SER	C	5	601 	HEM	C	B	1
FT	#HET	105	 126 	TRP	C	5	601 	HEM	C	S	6
FT	#HET	109	 130 	ARG	C	5	601 	HEM	C	S	6
FT	#HET	163	 184 	ILE	C	5	601 	HEM	C	S	1
FT	#HET	281	 302 	PHE	C	5	601 	HEM	C	A	4
FT	#HET	284	 305 	ALA	C	5	601 	HEM	C	A	8
FT	#HET	285	 306 	GLY	C	5	601 	HEM	C	B	2
FT	#HET	288	 309 	THR	C	5	601 	HEM	C	S	9
FT	#HET	292	 313 	VAL	C	5	601 	HEM	C	S	1
FT	#HET	348	 369 	VAL	C	5	601 	HEM	C	S	1
FT	#HET	349	 370 	ALA	C	5	601 	HEM	C	S	2
FT	#HET	352	 373 	LEU	C	5	601 	HEM	C	S	4
FT	#HET	354	 375 	ARG	C	5	601 	HEM	C	S	9
FT	#HET	412	 433 	PRO	C	5	601 	HEM	C	B	3
FT	#HET	413	 434 	PHE	C	5	601 	HEM	C	A	13
FT	#HET	414	 435 	GLY	C	5	601 	HEM	C	B	2
FT	#HET	418	 439 	ARG	C	5	601 	HEM	C	A	14
FT	#HET	419	 440 	ASN	C	5	601 	HEM	C	B	5
FT	#HET	420	 441 	CYS	C	5	601 	HEM	C	A	24
FT	#HET	421	 442 	ILE	C	5	601 	HEM	C	A	5
FT	#HET	422	 443 	GLY	C	5	601 	HEM	C	B	4
FT	#HET	425	 446 	PHE	C	5	601 	HEM	C	S	1
FT	#HET	426	 447 	ALA	C	5	601 	HEM	C	S	2
FT	#HET	430	 451 	MET	C	5	601 	HEM	C	S	1
FT	DISORDER	1	5
FT	DISORDER	475	480
CC	SEQUENCE	469 AA (ATOM);
CC	TRTHGLFKRL GIPGPTPLPL LGNVLSYRQG LWKFDTECYK KYGKMWGTYE GQLPVLAITD
CC	PDVIRTVLVK ECYSVFTNRR SLGPVGFMKS AISLAEDEEW KRIRSLLSPT FTSGKLKEMF
CC	PIIAQYGDVL VRNLRREAEK GKPVTLKDIF GAYSMDVITG TSFGVNIDSL NNPQDPFVES
CC	TKKFLKFGFL DPLFLSIILF PFLTPVFEAL NVSLFPKDTI NFLSKSVNRM KKSRLNDKQK
CC	HRLDFLQLMI DSQNSKETES HKALSDLELA AQSIIFIFAG YETTSSVLSF TLYELATHPD
CC	VQQKLQKEID AVLPNKAPPT YDAVVQMEYL DMVVNETLRL FPVAIRLERT CKKDVEINGV
CC	FIPKGSMVVI PTYALHHDPK YWTEPEEFRP ERFSKKKDSI DPYIYTPFGT GPRNCIGMRF
CC	ALMNMKLALI RVLQNFSFKP CKETQIPLKL DTQGLLQPEK PIVLKVDSR
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MALYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	ATOM   -----TRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	            *********************************************
CC	SEQRES WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	ATOM   WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	       **************************************************
CC	SEQRES EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	ATOM   EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	       **************************************************
CC	SEQRES LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	ATOM   LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	       **************************************************
CC	SEQRES SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	ATOM   SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	       **************************************************
CC	SEQRES LQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	ATOM   LQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	       **************************************************
CC	SEQRES ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	ATOM   ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	       **************************************************
CC	SEQRES RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK
CC	ATOM   RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK
CC	       **************************************************
CC	SEQRES KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	ATOM   KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	       **************************************************
CC	SEQRES IPLKLDTQGLLQPEKPIVLKVDSRDGHHHH
CC	ATOM   IPLKLDTQGLLQPEKPIVLKVDSR------
CC	       ************************      
SQ	SEQUENCE	480 AA;      MW;         CN;
	MALYGTRTHG LFKRLGIPGP TPLPLLGNVL SYRQGLWKFD TECYKKYGKM WGTYEGQLPV
	LAITDPDVIR TVLVKECYSV FTNRRSLGPV GFMKSAISLA EDEEWKRIRS LLSPTFTSGK
	LKEMFPIIAQ YGDVLVRNLR REAEKGKPVT LKDIFGAYSM DVITGTSFGV NIDSLNNPQD
	PFVESTKKFL KFGFLDPLFL SIILFPFLTP VFEALNVSLF PKDTINFLSK SVNRMKKSRL
	NDKQKHRLDF LQLMIDSQNS KETESHKALS DLELAAQSII FIFAGYETTS SVLSFTLYEL
	ATHPDVQQKL QKEIDAVLPN KAPPTYDAVV QMEYLDMVVN ETLRLFPVAI RLERTCKKDV
	EINGVFIPKG SMVVIPTYAL HHDPKYWTEP EEFRPERFSK KKDSIDPYIY TPFGTGPRNC
	IGMRFALMNM KLALIRVLQN FSFKPCKETQ IPLKLDTQGL LQPEKPIVLK VDSRDGHHHH
//
ID	5VEUD	STANDARD;	PRT;	480	AA.
DT	CONVERTED FROM PDB (SEQRES) 5VEU
DE	Cytochrome P450 3A5
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.910
CC	R-Factor	0.216
FT	#SUB	179	 200 	GLN	D	234	 255 	ARG	A	Protein	S	4
FT	#SUB	184	 205 	GLU	D	230	 251 	LYS	A	Protein	S	3
FT	#SUB	188	 209 	LYS	D	226	 247 	ASN	A	Protein	S	2
FT	#SUB	197	 218 	PRO	D	214	 235 	ALA	A	Protein	S	2
FT	#SUB	197	 218 	PRO	D	215	 236 	LEU	A	Protein	B	2
FT	#SUB	198	 219 	LEU	D	215	 236 	LEU	A	Protein	B	2
FT	#SUB	212	 233 	PHE	D	215	 236 	LEU	A	Protein	S	2
FT	#SUB	215	 236 	LEU	D	197	 218 	PRO	A	Protein	S	2
FT	#SUB	215	 236 	LEU	D	198	 219 	LEU	A	Protein	S	2
FT	#SUB	215	 236 	LEU	D	212	 233 	PHE	A	Protein	S	2
FT	#SUB	217	 238 	VAL	D	217	 238 	VAL	A	Protein	S	1
FT	#SUB	223	 244 	ASP	D	223	 244 	ASP	A	Protein	A	3
FT	#SUB	223	 244 	ASP	D	226	 247 	ASN	A	Protein	S	6
FT	#SUB	226	 247 	ASN	D	188	 209 	LYS	A	Protein	S	1
FT	#SUB	226	 247 	ASN	D	223	 244 	ASP	A	Protein	S	3
FT	#SUB	230	 251 	LYS	D	184	 205 	GLU	A	Protein	S	2
FT	#SUB	234	 255 	ARG	D	179	 200 	GLN	A	Protein	S	2
FT	#SUB	23	  44 	LEU	D	30	  51 	LEU	E	Protein	S	1
FT	#SUB	24	  45 	PRO	D	195	 216 	LEU	E	Protein	S	3
FT	#SUB	24	  45 	PRO	D	200	 221 	LEU	E	Protein	S	1
FT	#SUB	25	  46 	LEU	D	200	 221 	LEU	E	Protein	A	2
FT	#SUB	25	  46 	LEU	D	201	 222 	SER	E	Protein	S	3
FT	#SUB	25	  46 	LEU	D	204	 225 	LEU	E	Protein	S	1
FT	#SUB	26	  47 	LEU	D	26	  47 	LEU	E	Protein	S	1
FT	#SUB	26	  47 	LEU	D	204	 225 	LEU	E	Protein	S	1
FT	#SUB	30	  51 	LEU	D	24	  45 	PRO	E	Protein	S	2
FT	#SUB	33	  54 	ARG	D	24	  45 	PRO	E	Protein	S	2
FT	#SUB	195	 216 	LEU	D	25	  46 	LEU	E	Protein	S	1
FT	#SUB	200	 221 	LEU	D	25	  46 	LEU	E	Protein	S	1
FT	#SUB	204	 225 	LEU	D	205	 226 	PHE	E	Protein	S	2
FT	#SUB	207	 228 	PHE	D	211	 232 	VAL	I	Protein	S	4
FT	#SUB	207	 228 	PHE	D	214	 235 	ALA	I	Protein	S	2
FT	#SUB	211	 232 	VAL	D	211	 232 	VAL	I	Protein	S	1
FT	#SUB	214	 235 	ALA	D	207	 228 	PHE	I	Protein	S	2
FT	#HET	84	 105 	ARG	D	6	601 	HEM	D	S	10
FT	#HET	97	 118 	ILE	D	6	601 	HEM	D	A	2
FT	#HET	98	 119 	SER	D	6	601 	HEM	D	A	3
FT	#HET	105	 126 	TRP	D	6	601 	HEM	D	S	5
FT	#HET	109	 130 	ARG	D	6	601 	HEM	D	S	4
FT	#HET	116	 137 	PHE	D	6	601 	HEM	D	S	2
FT	#HET	163	 184 	ILE	D	6	601 	HEM	D	S	1
FT	#HET	281	 302 	PHE	D	6	601 	HEM	D	S	2
FT	#HET	284	 305 	ALA	D	6	601 	HEM	D	A	6
FT	#HET	285	 306 	GLY	D	6	601 	HEM	D	B	2
FT	#HET	288	 309 	THR	D	6	601 	HEM	D	S	9
FT	#HET	292	 313 	VAL	D	6	601 	HEM	D	S	1
FT	#HET	343	 364 	LEU	D	6	601 	HEM	D	S	1
FT	#HET	349	 370 	ALA	D	6	601 	HEM	D	S	1
FT	#HET	352	 373 	LEU	D	6	601 	HEM	D	S	4
FT	#HET	354	 375 	ARG	D	6	601 	HEM	D	S	9
FT	#HET	412	 433 	PRO	D	6	601 	HEM	D	B	3
FT	#HET	413	 434 	PHE	D	6	601 	HEM	D	A	12
FT	#HET	414	 435 	GLY	D	6	601 	HEM	D	B	1
FT	#HET	418	 439 	ARG	D	6	601 	HEM	D	A	11
FT	#HET	419	 440 	ASN	D	6	601 	HEM	D	B	3
FT	#HET	420	 441 	CYS	D	6	601 	HEM	D	A	25
FT	#HET	421	 442 	ILE	D	6	601 	HEM	D	S	3
FT	#HET	422	 443 	GLY	D	6	601 	HEM	D	B	1
FT	#HET	425	 446 	PHE	D	6	601 	HEM	D	S	3
FT	#HET	426	 447 	ALA	D	6	601 	HEM	D	S	2
FT	DISORDER	1	5
FT	DISORDER	261	267
FT	DISORDER	400	402
FT	DISORDER	475	480
CC	SEQUENCE	459 AA (ATOM);
CC	TRTHGLFKRL GIPGPTPLPL LGNVLSYRQG LWKFDTECYK KYGKMWGTYE GQLPVLAITD
CC	PDVIRTVLVK ECYSVFTNRR SLGPVGFMKS AISLAEDEEW KRIRSLLSPT FTSGKLKEMF
CC	PIIAQYGDVL VRNLRREAEK GKPVTLKDIF GAYSMDVITG TSFGVNIDSL NNPQDPFVES
CC	TKKFLKFGFL DPLFLSIILF PFLTPVFEAL NVSLFPKDTI NFLSKSVNRM KKSRLNDKQK
CC	HRLDFLQLMI DSQNSALSDL ELAAQSIIFI FAGYETTSSV LSFTLYELAT HPDVQQKLQK
CC	EIDAVLPNKA PPTYDAVVQM EYLDMVVNET LRLFPVAIRL ERTCKKDVEI NGVFIPKGSM
CC	VVIPTYALHH DPKYWTEPEE FRPERFSDSI DPYIYTPFGT GPRNCIGMRF ALMNMKLALI
CC	RVLQNFSFKP CKETQIPLKL DTQGLLQPEK PIVLKVDSR
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MALYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	ATOM   -----TRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	            *********************************************
CC	SEQRES WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	ATOM   WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	       **************************************************
CC	SEQRES EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	ATOM   EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	       **************************************************
CC	SEQRES LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	ATOM   LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	       **************************************************
CC	SEQRES SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	ATOM   SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	       **************************************************
CC	SEQRES LQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	ATOM   LQLMIDSQNS-------ALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	       **********       *********************************
CC	SEQRES ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	ATOM   ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	       **************************************************
CC	SEQRES RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK
CC	ATOM   RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-
CC	       ************************************************* 
CC	SEQRES KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	ATOM   --DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	         ************************************************
CC	SEQRES IPLKLDTQGLLQPEKPIVLKVDSRDGHHHH
CC	ATOM   IPLKLDTQGLLQPEKPIVLKVDSR------
CC	       ************************      
SQ	SEQUENCE	480 AA;      MW;         CN;
	MALYGTRTHG LFKRLGIPGP TPLPLLGNVL SYRQGLWKFD TECYKKYGKM WGTYEGQLPV
	LAITDPDVIR TVLVKECYSV FTNRRSLGPV GFMKSAISLA EDEEWKRIRS LLSPTFTSGK
	LKEMFPIIAQ YGDVLVRNLR REAEKGKPVT LKDIFGAYSM DVITGTSFGV NIDSLNNPQD
	PFVESTKKFL KFGFLDPLFL SIILFPFLTP VFEALNVSLF PKDTINFLSK SVNRMKKSRL
	NDKQKHRLDF LQLMIDSQNS KETESHKALS DLELAAQSII FIFAGYETTS SVLSFTLYEL
	ATHPDVQQKL QKEIDAVLPN KAPPTYDAVV QMEYLDMVVN ETLRLFPVAI RLERTCKKDV
	EINGVFIPKG SMVVIPTYAL HHDPKYWTEP EEFRPERFSK KKDSIDPYIY TPFGTGPRNC
	IGMRFALMNM KLALIRVLQN FSFKPCKETQ IPLKLDTQGL LQPEKPIVLK VDSRDGHHHH
//
ID	5VEUE	STANDARD;	PRT;	480	AA.
DT	CONVERTED FROM PDB (SEQRES) 5VEU
DE	Cytochrome P450 3A5
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.910
CC	R-Factor	0.216
FT	#SUB	207	 228 	PHE	E	211	 232 	VAL	A	Protein	A	6
FT	#SUB	207	 228 	PHE	E	214	 235 	ALA	A	Protein	S	2
FT	#SUB	210	 231 	PRO	E	207	 228 	PHE	A	Protein	A	5
FT	#SUB	211	 232 	VAL	E	207	 228 	PHE	A	Protein	A	5
FT	#SUB	214	 235 	ALA	E	207	 228 	PHE	A	Protein	S	2
FT	#SUB	49	  70 	LYS	E	122	 143 	LYS	B	Protein	S	1
FT	#SUB	65	  86 	ASP	E	122	 143 	LYS	B	Protein	S	1
FT	#SUB	67	  88 	ASP	E	119	 140 	GLY	B	Protein	S	5
FT	#SUB	70	  91 	ARG	E	123	 144 	GLU	B	Protein	S	1
FT	#SUB	71	  92 	THR	E	123	 144 	GLU	B	Protein	S	1
FT	#SUB	24	  45 	PRO	E	30	  51 	LEU	D	Protein	S	2
FT	#SUB	24	  45 	PRO	E	33	  54 	ARG	D	Protein	S	2
FT	#SUB	25	  46 	LEU	E	195	 216 	LEU	D	Protein	S	1
FT	#SUB	25	  46 	LEU	E	200	 221 	LEU	D	Protein	S	1
FT	#SUB	26	  47 	LEU	E	26	  47 	LEU	D	Protein	S	1
FT	#SUB	30	  51 	LEU	E	23	  44 	LEU	D	Protein	S	1
FT	#SUB	195	 216 	LEU	E	24	  45 	PRO	D	Protein	A	3
FT	#SUB	200	 221 	LEU	E	24	  45 	PRO	D	Protein	S	1
FT	#SUB	200	 221 	LEU	E	25	  46 	LEU	D	Protein	S	2
FT	#SUB	201	 222 	SER	E	25	  46 	LEU	D	Protein	A	3
FT	#SUB	204	 225 	LEU	E	25	  46 	LEU	D	Protein	S	1
FT	#SUB	204	 225 	LEU	E	26	  47 	LEU	D	Protein	S	1
FT	#SUB	205	 226 	PHE	E	204	 225 	LEU	D	Protein	S	2
FT	#SUB	212	 233 	PHE	E	215	 236 	LEU	I	Protein	S	1
FT	#SUB	215	 236 	LEU	E	212	 233 	PHE	I	Protein	S	3
FT	#SUB	215	 236 	LEU	E	215	 236 	LEU	I	Protein	S	1
FT	#SUB	226	 247 	ASN	E	223	 244 	ASP	I	Protein	S	3
FT	#SUB	234	 255 	ARG	E	179	 200 	GLN	I	Protein	S	8
FT	#HET	84	 105 	ARG	E	7	601 	HEM	E	S	12
FT	#HET	97	 118 	ILE	E	7	601 	HEM	E	A	4
FT	#HET	98	 119 	SER	E	7	601 	HEM	E	B	1
FT	#HET	105	 126 	TRP	E	7	601 	HEM	E	S	6
FT	#HET	109	 130 	ARG	E	7	601 	HEM	E	S	4
FT	#HET	163	 184 	ILE	E	7	601 	HEM	E	S	1
FT	#HET	281	 302 	PHE	E	7	601 	HEM	E	S	4
FT	#HET	284	 305 	ALA	E	7	601 	HEM	E	A	6
FT	#HET	285	 306 	GLY	E	7	601 	HEM	E	B	2
FT	#HET	288	 309 	THR	E	7	601 	HEM	E	A	8
FT	#HET	292	 313 	VAL	E	7	601 	HEM	E	S	1
FT	#HET	343	 364 	LEU	E	7	601 	HEM	E	S	1
FT	#HET	349	 370 	ALA	E	7	601 	HEM	E	S	1
FT	#HET	352	 373 	LEU	E	7	601 	HEM	E	S	1
FT	#HET	354	 375 	ARG	E	7	601 	HEM	E	S	9
FT	#HET	412	 433 	PRO	E	7	601 	HEM	E	B	5
FT	#HET	413	 434 	PHE	E	7	601 	HEM	E	A	10
FT	#HET	414	 435 	GLY	E	7	601 	HEM	E	B	2
FT	#HET	418	 439 	ARG	E	7	601 	HEM	E	A	10
FT	#HET	419	 440 	ASN	E	7	601 	HEM	E	B	3
FT	#HET	420	 441 	CYS	E	7	601 	HEM	E	A	25
FT	#HET	421	 442 	ILE	E	7	601 	HEM	E	A	4
FT	#HET	426	 447 	ALA	E	7	601 	HEM	E	S	1
FT	#HET	430	 451 	MET	E	7	601 	HEM	E	S	1
FT	DISORDER	1	5
FT	DISORDER	145	147
FT	DISORDER	242	247
FT	DISORDER	259	267
FT	DISORDER	400	404
FT	DISORDER	470	480
CC	SEQUENCE	441 AA (ATOM);
CC	TRTHGLFKRL GIPGPTPLPL LGNVLSYRQG LWKFDTECYK KYGKMWGTYE GQLPVLAITD
CC	PDVIRTVLVK ECYSVFTNRR SLGPVGFMKS AISLAEDEEW KRIRSLLSPT FTSGKLKEMF
CC	PIIAQYGDVL VRNLRREAEP VTLKDIFGAY SMDVITGTSF GVNIDSLNNP QDPFVESTKK
CC	FLKFGFLDPL FLSIILFPFL TPVFEALNVS LFPKDTINFL SKSVNRMKKS RLNLDFLQLM
CC	IDSQALSDLE LAAQSIIFIF AGYETTSSVL SFTLYELATH PDVQQKLQKE IDAVLPNKAP
CC	PTYDAVVQME YLDMVVNETL RLFPVAIRLE RTCKKDVEIN GVFIPKGSMV VIPTYALHHD
CC	PKYWTEPEEF RPERFSIDPY IYTPFGTGPR NCIGMRFALM NMKLALIRVL QNFSFKPCKE
CC	TQIPLKLDTQ GLLQPEKPIV L
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MALYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	ATOM   -----TRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	            *********************************************
CC	SEQRES WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	ATOM   WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	       **************************************************
CC	SEQRES EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	ATOM   EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAE---PVT
CC	       ********************************************   ***
CC	SEQRES LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	ATOM   LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	       **************************************************
CC	SEQRES SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	ATOM   SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLN------LDF
CC	       *****************************************      ***
CC	SEQRES LQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	ATOM   LQLMIDSQ---------ALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	       ********         *********************************
CC	SEQRES ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	ATOM   ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	       **************************************************
CC	SEQRES RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK
CC	ATOM   RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-
CC	       ************************************************* 
CC	SEQRES KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	ATOM   ----IDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	           **********************************************
CC	SEQRES IPLKLDTQGLLQPEKPIVLKVDSRDGHHHH
CC	ATOM   IPLKLDTQGLLQPEKPIVL-----------
CC	       *******************           
SQ	SEQUENCE	480 AA;      MW;         CN;
	MALYGTRTHG LFKRLGIPGP TPLPLLGNVL SYRQGLWKFD TECYKKYGKM WGTYEGQLPV
	LAITDPDVIR TVLVKECYSV FTNRRSLGPV GFMKSAISLA EDEEWKRIRS LLSPTFTSGK
	LKEMFPIIAQ YGDVLVRNLR REAEKGKPVT LKDIFGAYSM DVITGTSFGV NIDSLNNPQD
	PFVESTKKFL KFGFLDPLFL SIILFPFLTP VFEALNVSLF PKDTINFLSK SVNRMKKSRL
	NDKQKHRLDF LQLMIDSQNS KETESHKALS DLELAAQSII FIFAGYETTS SVLSFTLYEL
	ATHPDVQQKL QKEIDAVLPN KAPPTYDAVV QMEYLDMVVN ETLRLFPVAI RLERTCKKDV
	EINGVFIPKG SMVVIPTYAL HHDPKYWTEP EEFRPERFSK KKDSIDPYIY TPFGTGPRNC
	IGMRFALMNM KLALIRVLQN FSFKPCKETQ IPLKLDTQGL LQPEKPIVLK VDSRDGHHHH
//
ID	5VEUF	STANDARD;	PRT;	480	AA.
DT	CONVERTED FROM PDB (SEQRES) 5VEU
DE	Cytochrome P450 3A5
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.910
CC	R-Factor	0.216
FT	#SUB	184	 205 	GLU	F	230	 251 	LYS	B	Protein	S	2
FT	#SUB	197	 218 	PRO	F	214	 235 	ALA	B	Protein	S	2
FT	#SUB	197	 218 	PRO	F	215	 236 	LEU	B	Protein	B	1
FT	#SUB	201	 222 	SER	F	215	 236 	LEU	B	Protein	S	1
FT	#SUB	212	 233 	PHE	F	215	 236 	LEU	B	Protein	S	2
FT	#SUB	215	 236 	LEU	F	197	 218 	PRO	B	Protein	S	1
FT	#SUB	215	 236 	LEU	F	198	 219 	LEU	B	Protein	S	2
FT	#SUB	215	 236 	LEU	F	212	 233 	PHE	B	Protein	S	2
FT	#SUB	217	 238 	VAL	F	217	 238 	VAL	B	Protein	S	3
FT	#SUB	223	 244 	ASP	F	226	 247 	ASN	B	Protein	S	1
FT	#SUB	226	 247 	ASN	F	188	 209 	LYS	B	Protein	S	1
FT	#SUB	226	 247 	ASN	F	223	 244 	ASP	B	Protein	S	4
FT	#SUB	230	 251 	LYS	F	184	 205 	GLU	B	Protein	S	2
FT	#SUB	23	  44 	LEU	F	30	  51 	LEU	H	Protein	S	2
FT	#SUB	24	  45 	PRO	F	195	 216 	LEU	H	Protein	S	4
FT	#SUB	25	  46 	LEU	F	200	 221 	LEU	H	Protein	S	1
FT	#SUB	26	  47 	LEU	F	25	  46 	LEU	H	Protein	S	1
FT	#SUB	26	  47 	LEU	F	26	  47 	LEU	H	Protein	S	1
FT	#SUB	26	  47 	LEU	F	204	 225 	LEU	H	Protein	S	1
FT	#SUB	30	  51 	LEU	F	26	  47 	LEU	H	Protein	S	2
FT	#SUB	195	 216 	LEU	F	24	  45 	PRO	H	Protein	S	2
FT	#SUB	200	 221 	LEU	F	25	  46 	LEU	H	Protein	S	1
FT	#SUB	315	 336 	ASP	F	110	 131 	SER	K	Protein	B	1
FT	#SUB	319	 340 	PRO	F	110	 131 	SER	K	Protein	S	5
FT	#SUB	319	 340 	PRO	F	111	 132 	LEU	K	Protein	S	2
FT	#SUB	320	 341 	ASN	F	111	 132 	LEU	K	Protein	S	1
FT	#SUB	320	 341 	ASN	F	257	 278 	SER	K	Protein	S	1
FT	#SUB	320	 341 	ASN	F	268	 289 	ALA	K	Protein	S	3
FT	#SUB	207	 228 	PHE	F	214	 235 	ALA	L	Protein	S	6
FT	#SUB	210	 231 	PRO	F	207	 228 	PHE	L	Protein	B	1
FT	#SUB	211	 232 	VAL	F	207	 228 	PHE	L	Protein	A	2
FT	#SUB	211	 232 	VAL	F	211	 232 	VAL	L	Protein	S	1
FT	#SUB	214	 235 	ALA	F	207	 228 	PHE	L	Protein	S	4
FT	#HET	84	 105 	ARG	F	8	601 	HEM	F	S	9
FT	#HET	97	 118 	ILE	F	8	601 	HEM	F	A	4
FT	#HET	98	 119 	SER	F	8	601 	HEM	F	B	1
FT	#HET	105	 126 	TRP	F	8	601 	HEM	F	S	4
FT	#HET	109	 130 	ARG	F	8	601 	HEM	F	S	4
FT	#HET	116	 137 	PHE	F	8	601 	HEM	F	S	2
FT	#HET	163	 184 	ILE	F	8	601 	HEM	F	S	1
FT	#HET	281	 302 	PHE	F	8	601 	HEM	F	A	3
FT	#HET	284	 305 	ALA	F	8	601 	HEM	F	A	11
FT	#HET	285	 306 	GLY	F	8	601 	HEM	F	B	2
FT	#HET	288	 309 	THR	F	8	601 	HEM	F	S	9
FT	#HET	292	 313 	VAL	F	8	601 	HEM	F	S	1
FT	#HET	349	 370 	ALA	F	8	601 	HEM	F	S	1
FT	#HET	352	 373 	LEU	F	8	601 	HEM	F	S	4
FT	#HET	354	 375 	ARG	F	8	601 	HEM	F	S	9
FT	#HET	412	 433 	PRO	F	8	601 	HEM	F	B	6
FT	#HET	413	 434 	PHE	F	8	601 	HEM	F	A	15
FT	#HET	418	 439 	ARG	F	8	601 	HEM	F	A	10
FT	#HET	419	 440 	ASN	F	8	601 	HEM	F	B	5
FT	#HET	420	 441 	CYS	F	8	601 	HEM	F	A	21
FT	#HET	421	 442 	ILE	F	8	601 	HEM	F	S	2
FT	#HET	422	 443 	GLY	F	8	601 	HEM	F	B	1
FT	#HET	425	 446 	PHE	F	8	601 	HEM	F	S	1
FT	#HET	426	 447 	ALA	F	8	601 	HEM	F	S	3
FT	#HET	430	 451 	MET	F	8	601 	HEM	F	S	1
FT	DISORDER	1	7
FT	DISORDER	261	267
FT	DISORDER	400	403
FT	DISORDER	475	480
CC	SEQUENCE	456 AA (ATOM);
CC	THGLFKRLGI PGPTPLPLLG NVLSYRQGLW KFDTECYKKY GKMWGTYEGQ LPVLAITDPD
CC	VIRTVLVKEC YSVFTNRRSL GPVGFMKSAI SLAEDEEWKR IRSLLSPTFT SGKLKEMFPI
CC	IAQYGDVLVR NLRREAEKGK PVTLKDIFGA YSMDVITGTS FGVNIDSLNN PQDPFVESTK
CC	KFLKFGFLDP LFLSIILFPF LTPVFEALNV SLFPKDTINF LSKSVNRMKK SRLNDKQKHR
CC	LDFLQLMIDS QNSALSDLEL AAQSIIFIFA GYETTSSVLS FTLYELATHP DVQQKLQKEI
CC	DAVLPNKAPP TYDAVVQMEY LDMVVNETLR LFPVAIRLER TCKKDVEING VFIPKGSMVV
CC	IPTYALHHDP KYWTEPEEFR PERFSSIDPY IYTPFGTGPR NCIGMRFALM NMKLALIRVL
CC	QNFSFKPCKE TQIPLKLDTQ GLLQPEKPIV LKVDSR
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MALYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	ATOM   -------THGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	              *******************************************
CC	SEQRES WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	ATOM   WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	       **************************************************
CC	SEQRES EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	ATOM   EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	       **************************************************
CC	SEQRES LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	ATOM   LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	       **************************************************
CC	SEQRES SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	ATOM   SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	       **************************************************
CC	SEQRES LQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	ATOM   LQLMIDSQNS-------ALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	       **********       *********************************
CC	SEQRES ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	ATOM   ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	       **************************************************
CC	SEQRES RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK
CC	ATOM   RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-
CC	       ************************************************* 
CC	SEQRES KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	ATOM   ---SIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	          ***********************************************
CC	SEQRES IPLKLDTQGLLQPEKPIVLKVDSRDGHHHH
CC	ATOM   IPLKLDTQGLLQPEKPIVLKVDSR------
CC	       ************************      
SQ	SEQUENCE	480 AA;      MW;         CN;
	MALYGTRTHG LFKRLGIPGP TPLPLLGNVL SYRQGLWKFD TECYKKYGKM WGTYEGQLPV
	LAITDPDVIR TVLVKECYSV FTNRRSLGPV GFMKSAISLA EDEEWKRIRS LLSPTFTSGK
	LKEMFPIIAQ YGDVLVRNLR REAEKGKPVT LKDIFGAYSM DVITGTSFGV NIDSLNNPQD
	PFVESTKKFL KFGFLDPLFL SIILFPFLTP VFEALNVSLF PKDTINFLSK SVNRMKKSRL
	NDKQKHRLDF LQLMIDSQNS KETESHKALS DLELAAQSII FIFAGYETTS SVLSFTLYEL
	ATHPDVQQKL QKEIDAVLPN KAPPTYDAVV QMEYLDMVVN ETLRLFPVAI RLERTCKKDV
	EINGVFIPKG SMVVIPTYAL HHDPKYWTEP EEFRPERFSK KKDSIDPYIY TPFGTGPRNC
	IGMRFALMNM KLALIRVLQN FSFKPCKETQ IPLKLDTQGL LQPEKPIVLK VDSRDGHHHH
//
ID	5VEUG	STANDARD;	PRT;	480	AA.
DT	CONVERTED FROM PDB (SEQRES) 5VEU
DE	Cytochrome P450 3A5
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.910
CC	R-Factor	0.216
FT	#SUB	42	  63 	GLU	G	49	  70 	LYS	A	Protein	S	1
FT	#SUB	45	  66 	LYS	G	363	 384 	ASN	A	Protein	A	10
FT	#SUB	45	  66 	LYS	G	364	 385 	GLY	A	Protein	B	1
FT	#SUB	46	  67 	LYS	G	65	  86 	ASP	A	Protein	S	2
FT	#SUB	46	  67 	LYS	G	67	  88 	ASP	A	Protein	S	3
FT	#SUB	384	 405 	PRO	G	15	  36 	LEU	A	Protein	S	4
FT	#SUB	384	 405 	PRO	G	365	 386 	VAL	A	Protein	S	1
FT	#SUB	385	 406 	LYS	G	364	 385 	GLY	A	Protein	S	1
FT	#SUB	385	 406 	LYS	G	366	 387 	PHE	A	Protein	S	3
FT	#SUB	388	 409 	THR	G	14	  35 	ARG	A	Protein	S	1
FT	#SUB	389	 410 	GLU	G	13	  34 	LYS	A	Protein	A	6
FT	#SUB	389	 410 	GLU	G	14	  35 	ARG	A	Protein	A	6
FT	#SUB	390	 411 	PRO	G	14	  35 	ARG	A	Protein	S	1
FT	#SUB	390	 411 	PRO	G	15	  36 	LEU	A	Protein	S	1
FT	#SUB	390	 411 	PRO	G	16	  37 	GLY	A	Protein	S	1
FT	#SUB	392	 413 	GLU	G	13	  34 	LYS	A	Protein	S	2
FT	#SUB	23	  44 	LEU	G	30	  51 	LEU	C	Protein	S	4
FT	#SUB	24	  45 	PRO	G	195	 216 	LEU	C	Protein	S	5
FT	#SUB	25	  46 	LEU	G	197	 218 	PRO	C	Protein	S	1
FT	#SUB	25	  46 	LEU	G	204	 225 	LEU	C	Protein	S	1
FT	#SUB	26	  47 	LEU	G	26	  47 	LEU	C	Protein	S	2
FT	#SUB	26	  47 	LEU	G	204	 225 	LEU	C	Protein	S	2
FT	#SUB	33	  54 	ARG	G	23	  44 	LEU	C	Protein	S	2
FT	#SUB	33	  54 	ARG	G	24	  45 	PRO	C	Protein	S	2
FT	#SUB	195	 216 	LEU	G	24	  45 	PRO	C	Protein	S	2
FT	#SUB	200	 221 	LEU	G	25	  46 	LEU	C	Protein	S	1
FT	#SUB	200	 221 	LEU	G	205	 226 	PHE	C	Protein	S	2
FT	#SUB	204	 225 	LEU	G	204	 225 	LEU	C	Protein	S	1
FT	#SUB	204	 225 	LEU	G	205	 226 	PHE	C	Protein	S	2
FT	#SUB	205	 226 	PHE	G	205	 226 	PHE	C	Protein	S	1
FT	#SUB	474	 495 	ARG	G	447	 468 	LYS	I	Protein	A	5
FT	#SUB	179	 200 	GLN	G	234	 255 	ARG	J	Protein	S	1
FT	#SUB	188	 209 	LYS	G	226	 247 	ASN	J	Protein	S	1
FT	#SUB	197	 218 	PRO	G	214	 235 	ALA	J	Protein	S	1
FT	#SUB	197	 218 	PRO	G	215	 236 	LEU	J	Protein	A	3
FT	#SUB	198	 219 	LEU	G	215	 236 	LEU	J	Protein	B	1
FT	#SUB	212	 233 	PHE	G	215	 236 	LEU	J	Protein	S	2
FT	#SUB	214	 235 	ALA	G	197	 218 	PRO	J	Protein	B	2
FT	#SUB	215	 236 	LEU	G	197	 218 	PRO	J	Protein	S	3
FT	#SUB	215	 236 	LEU	G	198	 219 	LEU	J	Protein	S	1
FT	#SUB	215	 236 	LEU	G	212	 233 	PHE	J	Protein	S	2
FT	#SUB	217	 238 	VAL	G	217	 238 	VAL	J	Protein	S	2
FT	#SUB	222	 243 	LYS	G	222	 243 	LYS	J	Protein	S	1
FT	#SUB	223	 244 	ASP	G	223	 244 	ASP	J	Protein	S	1
FT	#SUB	223	 244 	ASP	G	226	 247 	ASN	J	Protein	S	6
FT	#SUB	226	 247 	ASN	G	223	 244 	ASP	J	Protein	S	7
FT	#SUB	230	 251 	LYS	G	184	 205 	GLU	J	Protein	S	2
FT	#SUB	234	 255 	ARG	G	179	 200 	GLN	J	Protein	S	3
FT	#SUB	207	 228 	PHE	G	210	 231 	PRO	K	Protein	S	5
FT	#SUB	207	 228 	PHE	G	211	 232 	VAL	K	Protein	S	4
FT	#SUB	207	 228 	PHE	G	214	 235 	ALA	K	Protein	S	2
FT	#SUB	211	 232 	VAL	G	207	 228 	PHE	K	Protein	A	3
FT	#SUB	211	 232 	VAL	G	211	 232 	VAL	K	Protein	S	1
FT	#SUB	214	 235 	ALA	G	207	 228 	PHE	K	Protein	S	2
FT	#HET	84	 105 	ARG	G	9	601 	HEM	G	S	10
FT	#HET	97	 118 	ILE	G	9	601 	HEM	G	A	6
FT	#HET	98	 119 	SER	G	9	601 	HEM	G	A	3
FT	#HET	105	 126 	TRP	G	9	601 	HEM	G	S	5
FT	#HET	109	 130 	ARG	G	9	601 	HEM	G	S	5
FT	#HET	163	 184 	ILE	G	9	601 	HEM	G	S	1
FT	#HET	281	 302 	PHE	G	9	601 	HEM	G	S	3
FT	#HET	284	 305 	ALA	G	9	601 	HEM	G	S	5
FT	#HET	285	 306 	GLY	G	9	601 	HEM	G	B	1
FT	#HET	288	 309 	THR	G	9	601 	HEM	G	A	7
FT	#HET	292	 313 	VAL	G	9	601 	HEM	G	S	1
FT	#HET	348	 369 	VAL	G	9	601 	HEM	G	S	1
FT	#HET	349	 370 	ALA	G	9	601 	HEM	G	S	1
FT	#HET	352	 373 	LEU	G	9	601 	HEM	G	S	4
FT	#HET	354	 375 	ARG	G	9	601 	HEM	G	S	8
FT	#HET	412	 433 	PRO	G	9	601 	HEM	G	B	3
FT	#HET	413	 434 	PHE	G	9	601 	HEM	G	A	12
FT	#HET	414	 435 	GLY	G	9	601 	HEM	G	B	2
FT	#HET	415	 436 	THR	G	9	601 	HEM	G	B	1
FT	#HET	418	 439 	ARG	G	9	601 	HEM	G	A	13
FT	#HET	419	 440 	ASN	G	9	601 	HEM	G	B	5
FT	#HET	420	 441 	CYS	G	9	601 	HEM	G	A	27
FT	#HET	421	 442 	ILE	G	9	601 	HEM	G	S	2
FT	#HET	422	 443 	GLY	G	9	601 	HEM	G	B	1
FT	#HET	425	 446 	PHE	G	9	601 	HEM	G	S	2
FT	#HET	426	 447 	ALA	G	9	601 	HEM	G	S	2
FT	#HET	430	 451 	MET	G	9	601 	HEM	G	S	1
FT	DISORDER	1	5
FT	DISORDER	244	246
FT	DISORDER	261	267
FT	DISORDER	400	403
FT	DISORDER	475	480
CC	SEQUENCE	455 AA (ATOM);
CC	TRTHGLFKRL GIPGPTPLPL LGNVLSYRQG LWKFDTECYK KYGKMWGTYE GQLPVLAITD
CC	PDVIRTVLVK ECYSVFTNRR SLGPVGFMKS AISLAEDEEW KRIRSLLSPT FTSGKLKEMF
CC	PIIAQYGDVL VRNLRREAEK GKPVTLKDIF GAYSMDVITG TSFGVNIDSL NNPQDPFVES
CC	TKKFLKFGFL DPLFLSIILF PFLTPVFEAL NVSLFPKDTI NFLSKSVNRM KKSRLNDKRL
CC	DFLQLMIDSQ NSALSDLELA AQSIIFIFAG YETTSSVLSF TLYELATHPD VQQKLQKEID
CC	AVLPNKAPPT YDAVVQMEYL DMVVNETLRL FPVAIRLERT CKKDVEINGV FIPKGSMVVI
CC	PTYALHHDPK YWTEPEEFRP ERFSSIDPYI YTPFGTGPRN CIGMRFALMN MKLALIRVLQ
CC	NFSFKPCKET QIPLKLDTQG LLQPEKPIVL KVDSR
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MALYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	ATOM   -----TRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	            *********************************************
CC	SEQRES WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	ATOM   WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	       **************************************************
CC	SEQRES EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	ATOM   EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	       **************************************************
CC	SEQRES LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	ATOM   LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	       **************************************************
CC	SEQRES SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	ATOM   SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDK---RLDF
CC	       *******************************************   ****
CC	SEQRES LQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	ATOM   LQLMIDSQNS-------ALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	       **********       *********************************
CC	SEQRES ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	ATOM   ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	       **************************************************
CC	SEQRES RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK
CC	ATOM   RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-
CC	       ************************************************* 
CC	SEQRES KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	ATOM   ---SIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	          ***********************************************
CC	SEQRES IPLKLDTQGLLQPEKPIVLKVDSRDGHHHH
CC	ATOM   IPLKLDTQGLLQPEKPIVLKVDSR------
CC	       ************************      
SQ	SEQUENCE	480 AA;      MW;         CN;
	MALYGTRTHG LFKRLGIPGP TPLPLLGNVL SYRQGLWKFD TECYKKYGKM WGTYEGQLPV
	LAITDPDVIR TVLVKECYSV FTNRRSLGPV GFMKSAISLA EDEEWKRIRS LLSPTFTSGK
	LKEMFPIIAQ YGDVLVRNLR REAEKGKPVT LKDIFGAYSM DVITGTSFGV NIDSLNNPQD
	PFVESTKKFL KFGFLDPLFL SIILFPFLTP VFEALNVSLF PKDTINFLSK SVNRMKKSRL
	NDKQKHRLDF LQLMIDSQNS KETESHKALS DLELAAQSII FIFAGYETTS SVLSFTLYEL
	ATHPDVQQKL QKEIDAVLPN KAPPTYDAVV QMEYLDMVVN ETLRLFPVAI RLERTCKKDV
	EINGVFIPKG SMVVIPTYAL HHDPKYWTEP EEFRPERFSK KKDSIDPYIY TPFGTGPRNC
	IGMRFALMNM KLALIRVLQN FSFKPCKETQ IPLKLDTQGL LQPEKPIVLK VDSRDGHHHH
//
ID	5VEUH	STANDARD;	PRT;	480	AA.
DT	CONVERTED FROM PDB (SEQRES) 5VEU
DE	Cytochrome P450 3A5
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.910
CC	R-Factor	0.216
FT	#SUB	207	 228 	PHE	H	210	 231 	PRO	B	Protein	S	1
FT	#SUB	207	 228 	PHE	H	211	 232 	VAL	B	Protein	S	3
FT	#SUB	207	 228 	PHE	H	214	 235 	ALA	B	Protein	S	2
FT	#SUB	210	 231 	PRO	H	207	 228 	PHE	B	Protein	S	1
FT	#SUB	211	 232 	VAL	H	207	 228 	PHE	B	Protein	S	1
FT	#SUB	214	 235 	ALA	H	207	 228 	PHE	B	Protein	S	2
FT	#SUB	24	  45 	PRO	H	195	 216 	LEU	F	Protein	S	2
FT	#SUB	25	  46 	LEU	H	26	  47 	LEU	F	Protein	S	1
FT	#SUB	25	  46 	LEU	H	200	 221 	LEU	F	Protein	S	1
FT	#SUB	26	  47 	LEU	H	26	  47 	LEU	F	Protein	S	1
FT	#SUB	26	  47 	LEU	H	30	  51 	LEU	F	Protein	S	2
FT	#SUB	30	  51 	LEU	H	23	  44 	LEU	F	Protein	S	2
FT	#SUB	195	 216 	LEU	H	24	  45 	PRO	F	Protein	A	4
FT	#SUB	200	 221 	LEU	H	25	  46 	LEU	F	Protein	S	1
FT	#SUB	204	 225 	LEU	H	26	  47 	LEU	F	Protein	S	1
FT	#SUB	212	 233 	PHE	H	215	 236 	LEU	L	Protein	S	1
FT	#SUB	215	 236 	LEU	H	212	 233 	PHE	L	Protein	S	1
FT	#SUB	215	 236 	LEU	H	215	 236 	LEU	L	Protein	S	1
FT	#SUB	217	 238 	VAL	H	215	 236 	LEU	L	Protein	S	1
FT	#HET	84	 105 	ARG	H	10	601 	HEM	H	S	11
FT	#HET	84	 105 	ARG	H	11	602 	RIT	H	S	8
FT	#HET	85	 106 	ARG	H	11	602 	RIT	H	S	1
FT	#HET	97	 118 	ILE	H	10	601 	HEM	H	S	3
FT	#HET	98	 119 	SER	H	10	601 	HEM	H	B	1
FT	#HET	98	 119 	SER	H	11	602 	RIT	H	S	2
FT	#HET	99	 120 	LEU	H	11	602 	RIT	H	S	1
FT	#HET	105	 126 	TRP	H	10	601 	HEM	H	S	3
FT	#HET	109	 130 	ARG	H	10	601 	HEM	H	S	5
FT	#HET	163	 184 	ILE	H	10	601 	HEM	H	S	1
FT	#HET	189	 210 	PHE	H	11	602 	RIT	H	S	5
FT	#HET	192	 213 	PHE	H	11	602 	RIT	H	A	5
FT	#HET	193	 214 	GLY	H	11	602 	RIT	H	B	1
FT	#HET	199	 220 	PHE	H	11	602 	RIT	H	S	3
FT	#HET	219	 240 	LEU	H	11	602 	RIT	H	A	6
FT	#HET	220	 241 	PHE	H	11	602 	RIT	H	S	2
FT	#HET	280	 301 	ILE	H	11	602 	RIT	H	S	3
FT	#HET	281	 302 	PHE	H	10	601 	HEM	H	A	6
FT	#HET	283	 304 	PHE	H	11	602 	RIT	H	S	12
FT	#HET	284	 305 	ALA	H	10	601 	HEM	H	A	8
FT	#HET	284	 305 	ALA	H	11	602 	RIT	H	S	4
FT	#HET	285	 306 	GLY	H	10	601 	HEM	H	B	2
FT	#HET	288	 309 	THR	H	10	601 	HEM	H	S	7
FT	#HET	288	 309 	THR	H	11	602 	RIT	H	S	2
FT	#HET	292	 313 	VAL	H	10	601 	HEM	H	S	1
FT	#HET	343	 364 	LEU	H	10	601 	HEM	H	S	1
FT	#HET	348	 369 	VAL	H	10	601 	HEM	H	S	4
FT	#HET	349	 370 	ALA	H	10	601 	HEM	H	S	1
FT	#HET	352	 373 	LEU	H	10	601 	HEM	H	S	5
FT	#HET	353	 374 	GLU	H	11	602 	RIT	H	S	3
FT	#HET	354	 375 	ARG	H	10	601 	HEM	H	S	7
FT	#HET	412	 433 	PRO	H	10	601 	HEM	H	B	6
FT	#HET	413	 434 	PHE	H	10	601 	HEM	H	A	9
FT	#HET	414	 435 	GLY	H	10	601 	HEM	H	B	1
FT	#HET	418	 439 	ARG	H	10	601 	HEM	H	A	13
FT	#HET	420	 441 	CYS	H	10	601 	HEM	H	A	24
FT	#HET	421	 442 	ILE	H	10	601 	HEM	H	S	4
FT	#HET	422	 443 	GLY	H	10	601 	HEM	H	B	1
FT	#HET	425	 446 	PHE	H	10	601 	HEM	H	S	1
FT	#HET	426	 447 	ALA	H	10	601 	HEM	H	S	2
FT	#HET	430	 451 	MET	H	10	601 	HEM	H	S	1
FT	#HET	459	 480 	GLY	H	11	602 	RIT	H	B	4
FT	#HET	460	 481 	LEU	H	11	602 	RIT	H	A	5
FT	DISORDER	1	5
FT	DISORDER	261	267
FT	DISORDER	400	402
FT	DISORDER	475	480
CC	SEQUENCE	459 AA (ATOM);
CC	TRTHGLFKRL GIPGPTPLPL LGNVLSYRQG LWKFDTECYK KYGKMWGTYE GQLPVLAITD
CC	PDVIRTVLVK ECYSVFTNRR SLGPVGFMKS AISLAEDEEW KRIRSLLSPT FTSGKLKEMF
CC	PIIAQYGDVL VRNLRREAEK GKPVTLKDIF GAYSMDVITG TSFGVNIDSL NNPQDPFVES
CC	TKKFLKFGFL DPLFLSIILF PFLTPVFEAL NVSLFPKDTI NFLSKSVNRM KKSRLNDKQK
CC	HRLDFLQLMI DSQNSALSDL ELAAQSIIFI FAGYETTSSV LSFTLYELAT HPDVQQKLQK
CC	EIDAVLPNKA PPTYDAVVQM EYLDMVVNET LRLFPVAIRL ERTCKKDVEI NGVFIPKGSM
CC	VVIPTYALHH DPKYWTEPEE FRPERFSDSI DPYIYTPFGT GPRNCIGMRF ALMNMKLALI
CC	RVLQNFSFKP CKETQIPLKL DTQGLLQPEK PIVLKVDSR
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MALYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	ATOM   -----TRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	            *********************************************
CC	SEQRES WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	ATOM   WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	       **************************************************
CC	SEQRES EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	ATOM   EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	       **************************************************
CC	SEQRES LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	ATOM   LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	       **************************************************
CC	SEQRES SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	ATOM   SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	       **************************************************
CC	SEQRES LQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	ATOM   LQLMIDSQNS-------ALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	       **********       *********************************
CC	SEQRES ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	ATOM   ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	       **************************************************
CC	SEQRES RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK
CC	ATOM   RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-
CC	       ************************************************* 
CC	SEQRES KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	ATOM   --DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	         ************************************************
CC	SEQRES IPLKLDTQGLLQPEKPIVLKVDSRDGHHHH
CC	ATOM   IPLKLDTQGLLQPEKPIVLKVDSR------
CC	       ************************      
SQ	SEQUENCE	480 AA;      MW;         CN;
	MALYGTRTHG LFKRLGIPGP TPLPLLGNVL SYRQGLWKFD TECYKKYGKM WGTYEGQLPV
	LAITDPDVIR TVLVKECYSV FTNRRSLGPV GFMKSAISLA EDEEWKRIRS LLSPTFTSGK
	LKEMFPIIAQ YGDVLVRNLR REAEKGKPVT LKDIFGAYSM DVITGTSFGV NIDSLNNPQD
	PFVESTKKFL KFGFLDPLFL SIILFPFLTP VFEALNVSLF PKDTINFLSK SVNRMKKSRL
	NDKQKHRLDF LQLMIDSQNS KETESHKALS DLELAAQSII FIFAGYETTS SVLSFTLYEL
	ATHPDVQQKL QKEIDAVLPN KAPPTYDAVV QMEYLDMVVN ETLRLFPVAI RLERTCKKDV
	EINGVFIPKG SMVVIPTYAL HHDPKYWTEP EEFRPERFSK KKDSIDPYIY TPFGTGPRNC
	IGMRFALMNM KLALIRVLQN FSFKPCKETQ IPLKLDTQGL LQPEKPIVLK VDSRDGHHHH
//
ID	5VEUI	STANDARD;	PRT;	480	AA.
DT	CONVERTED FROM PDB (SEQRES) 5VEU
DE	Cytochrome P450 3A5
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.910
CC	R-Factor	0.216
FT	#SUB	23	  44 	LEU	I	30	  51 	LEU	A	Protein	S	1
FT	#SUB	23	  44 	LEU	I	33	  54 	ARG	A	Protein	S	3
FT	#SUB	24	  45 	PRO	I	33	  54 	ARG	A	Protein	S	3
FT	#SUB	25	  46 	LEU	I	195	 216 	LEU	A	Protein	S	1
FT	#SUB	25	  46 	LEU	I	200	 221 	LEU	A	Protein	S	1
FT	#SUB	26	  47 	LEU	I	26	  47 	LEU	A	Protein	S	1
FT	#SUB	26	  47 	LEU	I	30	  51 	LEU	A	Protein	S	2
FT	#SUB	30	  51 	LEU	I	23	  44 	LEU	A	Protein	S	1
FT	#SUB	195	 216 	LEU	I	24	  45 	PRO	A	Protein	A	5
FT	#SUB	201	 222 	SER	I	25	  46 	LEU	A	Protein	B	2
FT	#SUB	204	 225 	LEU	I	25	  46 	LEU	A	Protein	S	1
FT	#SUB	204	 225 	LEU	I	26	  47 	LEU	A	Protein	S	1
FT	#SUB	204	 225 	LEU	I	204	 225 	LEU	A	Protein	S	1
FT	#SUB	205	 226 	PHE	I	204	 225 	LEU	A	Protein	S	2
FT	#SUB	205	 226 	PHE	I	205	 226 	PHE	A	Protein	S	1
FT	#SUB	207	 228 	PHE	I	214	 235 	ALA	D	Protein	S	2
FT	#SUB	211	 232 	VAL	I	207	 228 	PHE	D	Protein	A	4
FT	#SUB	211	 232 	VAL	I	211	 232 	VAL	D	Protein	S	1
FT	#SUB	214	 235 	ALA	I	207	 228 	PHE	D	Protein	S	2
FT	#SUB	179	 200 	GLN	I	234	 255 	ARG	E	Protein	S	8
FT	#SUB	212	 233 	PHE	I	215	 236 	LEU	E	Protein	S	3
FT	#SUB	215	 236 	LEU	I	212	 233 	PHE	E	Protein	S	1
FT	#SUB	215	 236 	LEU	I	215	 236 	LEU	E	Protein	S	1
FT	#SUB	223	 244 	ASP	I	226	 247 	ASN	E	Protein	S	3
FT	#SUB	447	 468 	LYS	I	474	 495 	ARG	G	Protein	S	5
FT	#HET	84	 105 	ARG	I	12	601 	HEM	I	S	12
FT	#HET	97	 118 	ILE	I	12	601 	HEM	I	A	4
FT	#HET	98	 119 	SER	I	12	601 	HEM	I	B	1
FT	#HET	105	 126 	TRP	I	12	601 	HEM	I	S	6
FT	#HET	109	 130 	ARG	I	12	601 	HEM	I	S	5
FT	#HET	163	 184 	ILE	I	12	601 	HEM	I	S	1
FT	#HET	281	 302 	PHE	I	12	601 	HEM	I	A	5
FT	#HET	284	 305 	ALA	I	12	601 	HEM	I	A	8
FT	#HET	285	 306 	GLY	I	12	601 	HEM	I	B	2
FT	#HET	288	 309 	THR	I	12	601 	HEM	I	S	7
FT	#HET	292	 313 	VAL	I	12	601 	HEM	I	S	1
FT	#HET	348	 369 	VAL	I	12	601 	HEM	I	S	1
FT	#HET	349	 370 	ALA	I	12	601 	HEM	I	S	1
FT	#HET	352	 373 	LEU	I	12	601 	HEM	I	S	2
FT	#HET	354	 375 	ARG	I	12	601 	HEM	I	S	9
FT	#HET	412	 433 	PRO	I	12	601 	HEM	I	B	3
FT	#HET	413	 434 	PHE	I	12	601 	HEM	I	A	9
FT	#HET	414	 435 	GLY	I	12	601 	HEM	I	B	2
FT	#HET	415	 436 	THR	I	12	601 	HEM	I	B	1
FT	#HET	418	 439 	ARG	I	12	601 	HEM	I	A	13
FT	#HET	419	 440 	ASN	I	12	601 	HEM	I	B	6
FT	#HET	420	 441 	CYS	I	12	601 	HEM	I	A	25
FT	#HET	421	 442 	ILE	I	12	601 	HEM	I	A	5
FT	#HET	422	 443 	GLY	I	12	601 	HEM	I	B	1
FT	#HET	425	 446 	PHE	I	12	601 	HEM	I	S	1
FT	#HET	426	 447 	ALA	I	12	601 	HEM	I	S	2
FT	#HET	430	 451 	MET	I	12	601 	HEM	I	S	1
FT	DISORDER	1	5
FT	DISORDER	400	404
FT	DISORDER	475	480
CC	SEQUENCE	464 AA (ATOM);
CC	TRTHGLFKRL GIPGPTPLPL LGNVLSYRQG LWKFDTECYK KYGKMWGTYE GQLPVLAITD
CC	PDVIRTVLVK ECYSVFTNRR SLGPVGFMKS AISLAEDEEW KRIRSLLSPT FTSGKLKEMF
CC	PIIAQYGDVL VRNLRREAEK GKPVTLKDIF GAYSMDVITG TSFGVNIDSL NNPQDPFVES
CC	TKKFLKFGFL DPLFLSIILF PFLTPVFEAL NVSLFPKDTI NFLSKSVNRM KKSRLNDKQK
CC	HRLDFLQLMI DSQNSKETES HKALSDLELA AQSIIFIFAG YETTSSVLSF TLYELATHPD
CC	VQQKLQKEID AVLPNKAPPT YDAVVQMEYL DMVVNETLRL FPVAIRLERT CKKDVEINGV
CC	FIPKGSMVVI PTYALHHDPK YWTEPEEFRP ERFSIDPYIY TPFGTGPRNC IGMRFALMNM
CC	KLALIRVLQN FSFKPCKETQ IPLKLDTQGL LQPEKPIVLK VDSR
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MALYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	ATOM   -----TRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	            *********************************************
CC	SEQRES WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	ATOM   WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	       **************************************************
CC	SEQRES EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	ATOM   EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	       **************************************************
CC	SEQRES LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	ATOM   LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	       **************************************************
CC	SEQRES SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	ATOM   SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	       **************************************************
CC	SEQRES LQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	ATOM   LQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	       **************************************************
CC	SEQRES ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	ATOM   ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	       **************************************************
CC	SEQRES RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK
CC	ATOM   RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-
CC	       ************************************************* 
CC	SEQRES KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	ATOM   ----IDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	           **********************************************
CC	SEQRES IPLKLDTQGLLQPEKPIVLKVDSRDGHHHH
CC	ATOM   IPLKLDTQGLLQPEKPIVLKVDSR------
CC	       ************************      
SQ	SEQUENCE	480 AA;      MW;         CN;
	MALYGTRTHG LFKRLGIPGP TPLPLLGNVL SYRQGLWKFD TECYKKYGKM WGTYEGQLPV
	LAITDPDVIR TVLVKECYSV FTNRRSLGPV GFMKSAISLA EDEEWKRIRS LLSPTFTSGK
	LKEMFPIIAQ YGDVLVRNLR REAEKGKPVT LKDIFGAYSM DVITGTSFGV NIDSLNNPQD
	PFVESTKKFL KFGFLDPLFL SIILFPFLTP VFEALNVSLF PKDTINFLSK SVNRMKKSRL
	NDKQKHRLDF LQLMIDSQNS KETESHKALS DLELAAQSII FIFAGYETTS SVLSFTLYEL
	ATHPDVQQKL QKEIDAVLPN KAPPTYDAVV QMEYLDMVVN ETLRLFPVAI RLERTCKKDV
	EINGVFIPKG SMVVIPTYAL HHDPKYWTEP EEFRPERFSK KKDSIDPYIY TPFGTGPRNC
	IGMRFALMNM KLALIRVLQN FSFKPCKETQ IPLKLDTQGL LQPEKPIVLK VDSRDGHHHH
//
ID	5VEUJ	STANDARD;	PRT;	480	AA.
DT	CONVERTED FROM PDB (SEQRES) 5VEU
DE	Cytochrome P450 3A5
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.910
CC	R-Factor	0.216
FT	#SUB	207	 228 	PHE	J	211	 232 	VAL	C	Protein	A	3
FT	#SUB	207	 228 	PHE	J	214	 235 	ALA	C	Protein	S	3
FT	#SUB	211	 232 	VAL	J	207	 228 	PHE	C	Protein	A	3
FT	#SUB	211	 232 	VAL	J	211	 232 	VAL	C	Protein	S	1
FT	#SUB	214	 235 	ALA	J	207	 228 	PHE	C	Protein	S	2
FT	#SUB	179	 200 	GLN	J	234	 255 	ARG	G	Protein	S	3
FT	#SUB	184	 205 	GLU	J	230	 251 	LYS	G	Protein	S	2
FT	#SUB	197	 218 	PRO	J	214	 235 	ALA	G	Protein	S	2
FT	#SUB	197	 218 	PRO	J	215	 236 	LEU	G	Protein	A	3
FT	#SUB	198	 219 	LEU	J	215	 236 	LEU	G	Protein	B	1
FT	#SUB	212	 233 	PHE	J	215	 236 	LEU	G	Protein	S	2
FT	#SUB	214	 235 	ALA	J	197	 218 	PRO	G	Protein	B	1
FT	#SUB	215	 236 	LEU	J	197	 218 	PRO	G	Protein	S	3
FT	#SUB	215	 236 	LEU	J	198	 219 	LEU	G	Protein	S	1
FT	#SUB	215	 236 	LEU	J	212	 233 	PHE	G	Protein	S	2
FT	#SUB	217	 238 	VAL	J	217	 238 	VAL	G	Protein	S	2
FT	#SUB	222	 243 	LYS	J	222	 243 	LYS	G	Protein	S	1
FT	#SUB	223	 244 	ASP	J	223	 244 	ASP	G	Protein	B	1
FT	#SUB	223	 244 	ASP	J	226	 247 	ASN	G	Protein	S	7
FT	#SUB	226	 247 	ASN	J	188	 209 	LYS	G	Protein	S	1
FT	#SUB	226	 247 	ASN	J	223	 244 	ASP	G	Protein	S	6
FT	#SUB	234	 255 	ARG	J	179	 200 	GLN	G	Protein	S	1
FT	#SUB	24	  45 	PRO	J	195	 216 	LEU	K	Protein	S	2
FT	#SUB	24	  45 	PRO	J	200	 221 	LEU	K	Protein	S	1
FT	#SUB	25	  46 	LEU	J	200	 221 	LEU	K	Protein	S	1
FT	#SUB	25	  46 	LEU	J	201	 222 	SER	K	Protein	S	3
FT	#SUB	25	  46 	LEU	J	204	 225 	LEU	K	Protein	S	1
FT	#SUB	26	  47 	LEU	J	25	  46 	LEU	K	Protein	S	1
FT	#SUB	26	  47 	LEU	J	26	  47 	LEU	K	Protein	S	1
FT	#SUB	26	  47 	LEU	J	204	 225 	LEU	K	Protein	S	1
FT	#SUB	30	  51 	LEU	J	24	  45 	PRO	K	Protein	S	3
FT	#SUB	33	  54 	ARG	J	24	  45 	PRO	K	Protein	S	6
FT	#SUB	200	 221 	LEU	J	25	  46 	LEU	K	Protein	S	1
FT	#SUB	204	 225 	LEU	J	205	 226 	PHE	K	Protein	S	1
FT	#HET	84	 105 	ARG	J	13	601 	HEM	J	S	9
FT	#HET	97	 118 	ILE	J	13	601 	HEM	J	A	2
FT	#HET	98	 119 	SER	J	13	601 	HEM	J	A	2
FT	#HET	105	 126 	TRP	J	13	601 	HEM	J	S	6
FT	#HET	109	 130 	ARG	J	13	601 	HEM	J	S	4
FT	#HET	116	 137 	PHE	J	13	601 	HEM	J	S	2
FT	#HET	163	 184 	ILE	J	13	601 	HEM	J	S	1
FT	#HET	281	 302 	PHE	J	13	601 	HEM	J	A	2
FT	#HET	284	 305 	ALA	J	13	601 	HEM	J	A	7
FT	#HET	285	 306 	GLY	J	13	601 	HEM	J	B	2
FT	#HET	288	 309 	THR	J	13	601 	HEM	J	S	12
FT	#HET	292	 313 	VAL	J	13	601 	HEM	J	S	1
FT	#HET	348	 369 	VAL	J	13	601 	HEM	J	S	1
FT	#HET	349	 370 	ALA	J	13	601 	HEM	J	S	1
FT	#HET	352	 373 	LEU	J	13	601 	HEM	J	S	6
FT	#HET	354	 375 	ARG	J	13	601 	HEM	J	S	9
FT	#HET	412	 433 	PRO	J	13	601 	HEM	J	B	3
FT	#HET	413	 434 	PHE	J	13	601 	HEM	J	A	12
FT	#HET	414	 435 	GLY	J	13	601 	HEM	J	B	2
FT	#HET	415	 436 	THR	J	13	601 	HEM	J	B	1
FT	#HET	418	 439 	ARG	J	13	601 	HEM	J	A	14
FT	#HET	419	 440 	ASN	J	13	601 	HEM	J	B	5
FT	#HET	420	 441 	CYS	J	13	601 	HEM	J	A	28
FT	#HET	421	 442 	ILE	J	13	601 	HEM	J	S	2
FT	#HET	422	 443 	GLY	J	13	601 	HEM	J	B	1
FT	#HET	425	 446 	PHE	J	13	601 	HEM	J	S	1
FT	#HET	426	 447 	ALA	J	13	601 	HEM	J	S	2
FT	#HET	430	 451 	MET	J	13	601 	HEM	J	S	1
FT	DISORDER	1	5
FT	DISORDER	261	267
FT	DISORDER	400	403
FT	DISORDER	475	480
CC	SEQUENCE	458 AA (ATOM);
CC	TRTHGLFKRL GIPGPTPLPL LGNVLSYRQG LWKFDTECYK KYGKMWGTYE GQLPVLAITD
CC	PDVIRTVLVK ECYSVFTNRR SLGPVGFMKS AISLAEDEEW KRIRSLLSPT FTSGKLKEMF
CC	PIIAQYGDVL VRNLRREAEK GKPVTLKDIF GAYSMDVITG TSFGVNIDSL NNPQDPFVES
CC	TKKFLKFGFL DPLFLSIILF PFLTPVFEAL NVSLFPKDTI NFLSKSVNRM KKSRLNDKQK
CC	HRLDFLQLMI DSQNSALSDL ELAAQSIIFI FAGYETTSSV LSFTLYELAT HPDVQQKLQK
CC	EIDAVLPNKA PPTYDAVVQM EYLDMVVNET LRLFPVAIRL ERTCKKDVEI NGVFIPKGSM
CC	VVIPTYALHH DPKYWTEPEE FRPERFSSID PYIYTPFGTG PRNCIGMRFA LMNMKLALIR
CC	VLQNFSFKPC KETQIPLKLD TQGLLQPEKP IVLKVDSR
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MALYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	ATOM   -----TRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	            *********************************************
CC	SEQRES WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	ATOM   WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	       **************************************************
CC	SEQRES EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	ATOM   EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	       **************************************************
CC	SEQRES LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	ATOM   LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	       **************************************************
CC	SEQRES SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	ATOM   SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	       **************************************************
CC	SEQRES LQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	ATOM   LQLMIDSQNS-------ALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	       **********       *********************************
CC	SEQRES ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	ATOM   ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	       **************************************************
CC	SEQRES RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK
CC	ATOM   RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-
CC	       ************************************************* 
CC	SEQRES KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	ATOM   ---SIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	          ***********************************************
CC	SEQRES IPLKLDTQGLLQPEKPIVLKVDSRDGHHHH
CC	ATOM   IPLKLDTQGLLQPEKPIVLKVDSR------
CC	       ************************      
SQ	SEQUENCE	480 AA;      MW;         CN;
	MALYGTRTHG LFKRLGIPGP TPLPLLGNVL SYRQGLWKFD TECYKKYGKM WGTYEGQLPV
	LAITDPDVIR TVLVKECYSV FTNRRSLGPV GFMKSAISLA EDEEWKRIRS LLSPTFTSGK
	LKEMFPIIAQ YGDVLVRNLR REAEKGKPVT LKDIFGAYSM DVITGTSFGV NIDSLNNPQD
	PFVESTKKFL KFGFLDPLFL SIILFPFLTP VFEALNVSLF PKDTINFLSK SVNRMKKSRL
	NDKQKHRLDF LQLMIDSQNS KETESHKALS DLELAAQSII FIFAGYETTS SVLSFTLYEL
	ATHPDVQQKL QKEIDAVLPN KAPPTYDAVV QMEYLDMVVN ETLRLFPVAI RLERTCKKDV
	EINGVFIPKG SMVVIPTYAL HHDPKYWTEP EEFRPERFSK KKDSIDPYIY TPFGTGPRNC
	IGMRFALMNM KLALIRVLQN FSFKPCKETQ IPLKLDTQGL LQPEKPIVLK VDSRDGHHHH
//
ID	5VEUK	STANDARD;	PRT;	480	AA.
DT	CONVERTED FROM PDB (SEQRES) 5VEU
DE	Cytochrome P450 3A5
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.910
CC	R-Factor	0.216
FT	#SUB	179	 200 	GLN	K	234	 255 	ARG	C	Protein	S	1
FT	#SUB	184	 205 	GLU	K	230	 251 	LYS	C	Protein	S	1
FT	#SUB	184	 205 	GLU	K	234	 255 	ARG	C	Protein	S	3
FT	#SUB	212	 233 	PHE	K	215	 236 	LEU	C	Protein	S	1
FT	#SUB	215	 236 	LEU	K	212	 233 	PHE	C	Protein	S	3
FT	#SUB	215	 236 	LEU	K	215	 236 	LEU	C	Protein	S	1
FT	#SUB	223	 244 	ASP	K	223	 244 	ASP	C	Protein	A	2
FT	#SUB	223	 244 	ASP	K	226	 247 	ASN	C	Protein	S	3
FT	#SUB	226	 247 	ASN	K	223	 244 	ASP	C	Protein	S	4
FT	#SUB	234	 255 	ARG	K	179	 200 	GLN	C	Protein	S	6
FT	#SUB	234	 255 	ARG	K	184	 205 	GLU	C	Protein	S	5
FT	#SUB	110	 131 	SER	K	315	 336 	ASP	F	Protein	S	1
FT	#SUB	110	 131 	SER	K	319	 340 	PRO	F	Protein	A	5
FT	#SUB	111	 132 	LEU	K	319	 340 	PRO	F	Protein	B	2
FT	#SUB	111	 132 	LEU	K	320	 341 	ASN	F	Protein	S	1
FT	#SUB	257	 278 	SER	K	320	 341 	ASN	F	Protein	S	1
FT	#SUB	268	 289 	ALA	K	320	 341 	ASN	F	Protein	B	3
FT	#SUB	207	 228 	PHE	K	211	 232 	VAL	G	Protein	A	3
FT	#SUB	207	 228 	PHE	K	214	 235 	ALA	G	Protein	S	2
FT	#SUB	210	 231 	PRO	K	207	 228 	PHE	G	Protein	A	5
FT	#SUB	211	 232 	VAL	K	207	 228 	PHE	G	Protein	A	4
FT	#SUB	211	 232 	VAL	K	211	 232 	VAL	G	Protein	S	1
FT	#SUB	214	 235 	ALA	K	207	 228 	PHE	G	Protein	S	2
FT	#SUB	24	  45 	PRO	K	30	  51 	LEU	J	Protein	S	3
FT	#SUB	24	  45 	PRO	K	33	  54 	ARG	J	Protein	S	6
FT	#SUB	25	  46 	LEU	K	26	  47 	LEU	J	Protein	S	1
FT	#SUB	25	  46 	LEU	K	200	 221 	LEU	J	Protein	S	1
FT	#SUB	26	  47 	LEU	K	26	  47 	LEU	J	Protein	S	1
FT	#SUB	195	 216 	LEU	K	24	  45 	PRO	J	Protein	S	2
FT	#SUB	200	 221 	LEU	K	24	  45 	PRO	J	Protein	S	1
FT	#SUB	200	 221 	LEU	K	25	  46 	LEU	J	Protein	S	1
FT	#SUB	201	 222 	SER	K	25	  46 	LEU	J	Protein	A	3
FT	#SUB	204	 225 	LEU	K	25	  46 	LEU	J	Protein	S	1
FT	#SUB	204	 225 	LEU	K	26	  47 	LEU	J	Protein	S	1
FT	#SUB	205	 226 	PHE	K	204	 225 	LEU	J	Protein	S	1
FT	#HET	84	 105 	ARG	K	14	601 	HEM	K	S	10
FT	#HET	97	 118 	ILE	K	14	601 	HEM	K	A	5
FT	#HET	98	 119 	SER	K	14	601 	HEM	K	B	1
FT	#HET	105	 126 	TRP	K	14	601 	HEM	K	S	6
FT	#HET	109	 130 	ARG	K	14	601 	HEM	K	S	5
FT	#HET	163	 184 	ILE	K	14	601 	HEM	K	S	1
FT	#HET	281	 302 	PHE	K	14	601 	HEM	K	S	3
FT	#HET	284	 305 	ALA	K	14	601 	HEM	K	A	7
FT	#HET	288	 309 	THR	K	14	601 	HEM	K	A	7
FT	#HET	292	 313 	VAL	K	14	601 	HEM	K	S	1
FT	#HET	348	 369 	VAL	K	14	601 	HEM	K	S	1
FT	#HET	349	 370 	ALA	K	14	601 	HEM	K	S	1
FT	#HET	352	 373 	LEU	K	14	601 	HEM	K	S	6
FT	#HET	354	 375 	ARG	K	14	601 	HEM	K	S	9
FT	#HET	412	 433 	PRO	K	14	601 	HEM	K	B	6
FT	#HET	413	 434 	PHE	K	14	601 	HEM	K	A	14
FT	#HET	414	 435 	GLY	K	14	601 	HEM	K	B	2
FT	#HET	418	 439 	ARG	K	14	601 	HEM	K	A	10
FT	#HET	419	 440 	ASN	K	14	601 	HEM	K	B	2
FT	#HET	420	 441 	CYS	K	14	601 	HEM	K	A	25
FT	#HET	421	 442 	ILE	K	14	601 	HEM	K	S	2
FT	#HET	422	 443 	GLY	K	14	601 	HEM	K	B	1
FT	#HET	425	 446 	PHE	K	14	601 	HEM	K	S	1
FT	#HET	426	 447 	ALA	K	14	601 	HEM	K	S	2
FT	#HET	430	 451 	MET	K	14	601 	HEM	K	S	1
FT	DISORDER	1	5
FT	DISORDER	260	267
FT	DISORDER	400	402
FT	DISORDER	475	480
CC	SEQUENCE	458 AA (ATOM);
CC	TRTHGLFKRL GIPGPTPLPL LGNVLSYRQG LWKFDTECYK KYGKMWGTYE GQLPVLAITD
CC	PDVIRTVLVK ECYSVFTNRR SLGPVGFMKS AISLAEDEEW KRIRSLLSPT FTSGKLKEMF
CC	PIIAQYGDVL VRNLRREAEK GKPVTLKDIF GAYSMDVITG TSFGVNIDSL NNPQDPFVES
CC	TKKFLKFGFL DPLFLSIILF PFLTPVFEAL NVSLFPKDTI NFLSKSVNRM KKSRLNDKQK
CC	HRLDFLQLMI DSQNALSDLE LAAQSIIFIF AGYETTSSVL SFTLYELATH PDVQQKLQKE
CC	IDAVLPNKAP PTYDAVVQME YLDMVVNETL RLFPVAIRLE RTCKKDVEIN GVFIPKGSMV
CC	VIPTYALHHD PKYWTEPEEF RPERFSDSID PYIYTPFGTG PRNCIGMRFA LMNMKLALIR
CC	VLQNFSFKPC KETQIPLKLD TQGLLQPEKP IVLKVDSR
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MALYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	ATOM   -----TRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	            *********************************************
CC	SEQRES WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	ATOM   WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	       **************************************************
CC	SEQRES EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	ATOM   EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	       **************************************************
CC	SEQRES LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	ATOM   LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	       **************************************************
CC	SEQRES SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	ATOM   SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	       **************************************************
CC	SEQRES LQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	ATOM   LQLMIDSQN--------ALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	       *********        *********************************
CC	SEQRES ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	ATOM   ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	       **************************************************
CC	SEQRES RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK
CC	ATOM   RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-
CC	       ************************************************* 
CC	SEQRES KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	ATOM   --DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	         ************************************************
CC	SEQRES IPLKLDTQGLLQPEKPIVLKVDSRDGHHHH
CC	ATOM   IPLKLDTQGLLQPEKPIVLKVDSR------
CC	       ************************      
SQ	SEQUENCE	480 AA;      MW;         CN;
	MALYGTRTHG LFKRLGIPGP TPLPLLGNVL SYRQGLWKFD TECYKKYGKM WGTYEGQLPV
	LAITDPDVIR TVLVKECYSV FTNRRSLGPV GFMKSAISLA EDEEWKRIRS LLSPTFTSGK
	LKEMFPIIAQ YGDVLVRNLR REAEKGKPVT LKDIFGAYSM DVITGTSFGV NIDSLNNPQD
	PFVESTKKFL KFGFLDPLFL SIILFPFLTP VFEALNVSLF PKDTINFLSK SVNRMKKSRL
	NDKQKHRLDF LQLMIDSQNS KETESHKALS DLELAAQSII FIFAGYETTS SVLSFTLYEL
	ATHPDVQQKL QKEIDAVLPN KAPPTYDAVV QMEYLDMVVN ETLRLFPVAI RLERTCKKDV
	EINGVFIPKG SMVVIPTYAL HHDPKYWTEP EEFRPERFSK KKDSIDPYIY TPFGTGPRNC
	IGMRFALMNM KLALIRVLQN FSFKPCKETQ IPLKLDTQGL LQPEKPIVLK VDSRDGHHHH
//
ID	5VEUL	STANDARD;	PRT;	480	AA.
DT	CONVERTED FROM PDB (SEQRES) 5VEU
DE	Cytochrome P450 3A5
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.910
CC	R-Factor	0.216
FT	#SUB	24	  45 	PRO	L	33	  54 	ARG	B	Protein	S	2
FT	#SUB	24	  45 	PRO	L	195	 216 	LEU	B	Protein	S	1
FT	#SUB	25	  46 	LEU	L	195	 216 	LEU	B	Protein	S	2
FT	#SUB	25	  46 	LEU	L	200	 221 	LEU	B	Protein	S	1
FT	#SUB	26	  47 	LEU	L	30	  51 	LEU	B	Protein	S	1
FT	#SUB	30	  51 	LEU	L	23	  44 	LEU	B	Protein	S	1
FT	#SUB	195	 216 	LEU	L	24	  45 	PRO	B	Protein	A	5
FT	#SUB	200	 221 	LEU	L	25	  46 	LEU	B	Protein	S	3
FT	#SUB	201	 222 	SER	L	25	  46 	LEU	B	Protein	B	1
FT	#SUB	204	 225 	LEU	L	26	  47 	LEU	B	Protein	S	2
FT	#SUB	204	 225 	LEU	L	204	 225 	LEU	B	Protein	S	1
FT	#SUB	205	 226 	PHE	L	200	 221 	LEU	B	Protein	S	1
FT	#SUB	205	 226 	PHE	L	205	 226 	PHE	B	Protein	S	1
FT	#SUB	207	 228 	PHE	L	210	 231 	PRO	F	Protein	S	1
FT	#SUB	207	 228 	PHE	L	211	 232 	VAL	F	Protein	A	2
FT	#SUB	207	 228 	PHE	L	214	 235 	ALA	F	Protein	S	4
FT	#SUB	211	 232 	VAL	L	211	 232 	VAL	F	Protein	S	1
FT	#SUB	214	 235 	ALA	L	207	 228 	PHE	F	Protein	S	6
FT	#SUB	212	 233 	PHE	L	215	 236 	LEU	H	Protein	S	1
FT	#SUB	215	 236 	LEU	L	212	 233 	PHE	H	Protein	S	1
FT	#SUB	215	 236 	LEU	L	215	 236 	LEU	H	Protein	S	1
FT	#SUB	215	 236 	LEU	L	217	 238 	VAL	H	Protein	B	1
FT	#HET	84	 105 	ARG	L	15	601 	HEM	L	S	14
FT	#HET	97	 118 	ILE	L	15	601 	HEM	L	A	4
FT	#HET	98	 119 	SER	L	15	601 	HEM	L	A	4
FT	#HET	105	 126 	TRP	L	15	601 	HEM	L	S	6
FT	#HET	109	 130 	ARG	L	15	601 	HEM	L	S	5
FT	#HET	116	 137 	PHE	L	15	601 	HEM	L	S	2
FT	#HET	163	 184 	ILE	L	15	601 	HEM	L	S	1
FT	#HET	281	 302 	PHE	L	15	601 	HEM	L	S	7
FT	#HET	284	 305 	ALA	L	15	601 	HEM	L	A	7
FT	#HET	285	 306 	GLY	L	15	601 	HEM	L	B	2
FT	#HET	288	 309 	THR	L	15	601 	HEM	L	A	10
FT	#HET	292	 313 	VAL	L	15	601 	HEM	L	S	1
FT	#HET	348	 369 	VAL	L	15	601 	HEM	L	S	1
FT	#HET	349	 370 	ALA	L	15	601 	HEM	L	S	1
FT	#HET	352	 373 	LEU	L	15	601 	HEM	L	S	3
FT	#HET	354	 375 	ARG	L	15	601 	HEM	L	S	9
FT	#HET	412	 433 	PRO	L	15	601 	HEM	L	B	3
FT	#HET	413	 434 	PHE	L	15	601 	HEM	L	A	14
FT	#HET	414	 435 	GLY	L	15	601 	HEM	L	B	1
FT	#HET	418	 439 	ARG	L	15	601 	HEM	L	A	9
FT	#HET	419	 440 	ASN	L	15	601 	HEM	L	B	5
FT	#HET	420	 441 	CYS	L	15	601 	HEM	L	A	22
FT	#HET	421	 442 	ILE	L	15	601 	HEM	L	S	1
FT	#HET	425	 446 	PHE	L	15	601 	HEM	L	S	1
FT	#HET	426	 447 	ALA	L	15	601 	HEM	L	S	2
FT	#HET	430	 451 	MET	L	15	601 	HEM	L	S	1
FT	DISORDER	1	5
FT	DISORDER	242	249
FT	DISORDER	261	267
FT	DISORDER	400	404
FT	DISORDER	474	480
CC	SEQUENCE	448 AA (ATOM);
CC	TRTHGLFKRL GIPGPTPLPL LGNVLSYRQG LWKFDTECYK KYGKMWGTYE GQLPVLAITD
CC	PDVIRTVLVK ECYSVFTNRR SLGPVGFMKS AISLAEDEEW KRIRSLLSPT FTSGKLKEMF
CC	PIIAQYGDVL VRNLRREAEK GKPVTLKDIF GAYSMDVITG TSFGVNIDSL NNPQDPFVES
CC	TKKFLKFGFL DPLFLSIILF PFLTPVFEAL NVSLFPKDTI NFLSKSVNRM KKSRLNFLQL
CC	MIDSQNSALS DLELAAQSII FIFAGYETTS SVLSFTLYEL ATHPDVQQKL QKEIDAVLPN
CC	KAPPTYDAVV QMEYLDMVVN ETLRLFPVAI RLERTCKKDV EINGVFIPKG SMVVIPTYAL
CC	HHDPKYWTEP EEFRPERFSI DPYIYTPFGT GPRNCIGMRF ALMNMKLALI RVLQNFSFKP
CC	CKETQIPLKL DTQGLLQPEK PIVLKVDS
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MALYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	ATOM   -----TRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM
CC	            *********************************************
CC	SEQRES WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	ATOM   WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA
CC	       **************************************************
CC	SEQRES EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	ATOM   EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
CC	       **************************************************
CC	SEQRES LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	ATOM   LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL
CC	       **************************************************
CC	SEQRES SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF
CC	ATOM   SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLN--------F
CC	       *****************************************        *
CC	SEQRES LQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	ATOM   LQLMIDSQNS-------ALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL
CC	       **********       *********************************
CC	SEQRES ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	ATOM   ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI
CC	       **************************************************
CC	SEQRES RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK
CC	ATOM   RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-
CC	       ************************************************* 
CC	SEQRES KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	ATOM   ----IDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ
CC	           **********************************************
CC	SEQRES IPLKLDTQGLLQPEKPIVLKVDSRDGHHHH
CC	ATOM   IPLKLDTQGLLQPEKPIVLKVDS-------
CC	       ***********************       
SQ	SEQUENCE	480 AA;      MW;         CN;
	MALYGTRTHG LFKRLGIPGP TPLPLLGNVL SYRQGLWKFD TECYKKYGKM WGTYEGQLPV
	LAITDPDVIR TVLVKECYSV FTNRRSLGPV GFMKSAISLA EDEEWKRIRS LLSPTFTSGK
	LKEMFPIIAQ YGDVLVRNLR REAEKGKPVT LKDIFGAYSM DVITGTSFGV NIDSLNNPQD
	PFVESTKKFL KFGFLDPLFL SIILFPFLTP VFEALNVSLF PKDTINFLSK SVNRMKKSRL
	NDKQKHRLDF LQLMIDSQNS KETESHKALS DLELAAQSII FIFAGYETTS SVLSFTLYEL
	ATHPDVQQKL QKEIDAVLPN KAPPTYDAVV QMEYLDMVVN ETLRLFPVAI RLERTCKKDV
	EINGVFIPKG SMVVIPTYAL HHDPKYWTEP EEFRPERFSK KKDSIDPYIY TPFGTGPRNC
	IGMRFALMNM KLALIRVLQN FSFKPCKETQ IPLKLDTQGL LQPEKPIVLK VDSRDGHHHH
//