ID	5IE1A	STANDARD;	PRT;	411	AA.
DT	CONVERTED FROM PDB (SEQRES) 5IE1
DE	Beta-secretase 1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.300
CC	R-Factor	0.216
FT	#HET	28	   9 	LYS	A	5	405 	GOL	A	B	2
FT	#HET	29	  10 	SER	A	5	405 	GOL	A	B	1
FT	#HET	30	  11 	GLY	A	5	405 	GOL	A	B	4
FT	#HET	31	  12 	GLN	A	5	405 	GOL	A	B	1
FT	#HET	32	  13 	GLY	A	5	405 	GOL	A	B	6
FT	#HET	33	  14 	TYR	A	5	405 	GOL	A	S	3
FT	#HET	51	  32 	ASP	A	7	407 	6BS	A	S	11
FT	#HET	53	  34 	GLY	A	7	407 	6BS	A	B	9
FT	#HET	54	  35 	SER	A	7	407 	6BS	A	A	3
FT	#HET	69	  50 	ARG	A	6	406 	GOL	A	A	3
FT	#HET	70	  51 	TYR	A	6	406 	GOL	A	A	6
FT	#HET	72	  53 	GLN	A	6	406 	GOL	A	S	7
FT	#HET	88	  69 	VAL	A	7	407 	6BS	A	B	1
FT	#HET	90	  71 	TYR	A	7	407 	6BS	A	S	14
FT	#HET	93	  74 	GLY	A	7	407 	6BS	A	B	1
FT	#HET	94	  75 	LYS	A	7	407 	6BS	A	B	6
FT	#HET	95	  76 	TRP	A	7	407 	6BS	A	A	6
FT	#HET	115	  96 	ARG	A	3	403 	IOD	A	B	1
FT	#HET	122	 103 	THR	A	1	401 	IOD	A	B	2
FT	#HET	123	 104 	GLU	A	1	401 	IOD	A	B	3
FT	#HET	124	 105 	SER	A	1	401 	IOD	A	A	2
FT	#HET	126	 107 	LYS	A	2	402 	IOD	A	B	1
FT	#HET	126	 107 	LYS	A	7	407 	6BS	A	B	1
FT	#HET	127	 108 	PHE	A	7	407 	6BS	A	S	7
FT	#HET	137	 118 	ILE	A	7	407 	6BS	A	S	1
FT	#HET	147	 128 	ARG	A	7	407 	6BS	A	S	4
FT	#HET	189	 170 	VAL	A	5	405 	GOL	A	S	1
FT	#HET	217	 198 	TYR	A	7	407 	6BS	A	S	6
FT	#HET	247	 228 	ASP	A	7	407 	6BS	A	S	6
FT	#HET	248	 229 	SER	A	5	405 	GOL	A	B	1
FT	#HET	249	 230 	GLY	A	5	405 	GOL	A	B	1
FT	#HET	250	 231 	THR	A	5	405 	GOL	A	B	2
FT	#HET	250	 231 	THR	A	7	407 	6BS	A	S	1
FT	#HET	251	 232 	THR	A	5	405 	GOL	A	A	7
FT	#HET	354	 335 	ALA	A	5	405 	GOL	A	S	3
FT	#HET	358	 339 	GLU	A	5	405 	GOL	A	S	1
FT	#HET	368	 349 	ARG	A	4	404 	IOD	A	S	2
FT	#HET	370	 351 	ARG	A	4	404 	IOD	A	S	1
FT	DISORDER	1	17
FT	DISORDER	176	186
FT	DISORDER	291	297
FT	DISORDER	329	336
FT	DISORDER	405	411
CC	SEQUENCE	361 AA (ATOM);
CC	FVEMVDNLRG KSGQGYYVEM TVGSPPQTLN ILVDTGSSNF AVGAAPHPFL HRYYQRQLSS
CC	TYRDLRKGVY VPYTQGKWEG ELGTDLVSIP HGPNVTVRAN IAAITESDKF FINGSNWEGI
CC	LGLAYAEIAR PDDSLEPFFD SLVKQTHVPN LFSLQLCGAS VGGSMIIGGI DHSLYTGSLW
CC	YTPIRREWYY EVIIVRVEIN GQDLKMDCKE YNYDKSIVDS GTTNLRLPKK VFEAAVKSIK
CC	AASSTEKFPD GFWLGEQLVC WQIFPVISLY LMGEVTNQSF RITILPQQYL RPVDCYKFAI
CC	SQSSTGTVMG AVIMEGFYVV FDRARKRIGF AVSACHVHDE FRTAAVEGPF VTLDMEDCGY
CC	N
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES LPRETDEEPEEPGKKGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILV
CC	ATOM   -----------------FVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILV
CC	                        *********************************
CC	SEQRES DTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELG
CC	ATOM   DTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELG
CC	       **************************************************
CC	SEQRES TDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDD
CC	ATOM   TDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDD
CC	       **************************************************
CC	SEQRES SLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDH
CC	ATOM   SLEPFFDSLVKQTHVPNLFSLQLCG-----------ASVGGSMIIGGIDH
CC	       *************************           **************
CC	SEQRES SLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGT
CC	ATOM   SLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGT
CC	       **************************************************
CC	SEQRES TNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFP
CC	ATOM   TNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQ-------IFP
CC	       ****************************************       ***
CC	SEQRES VISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGT
CC	ATOM   VISLYLMGEVTNQSFRITILPQQYLRPV--------DCYKFAISQSSTGT
CC	       ****************************        **************
CC	SEQRES VMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMED
CC	ATOM   VMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMED
CC	       **************************************************
CC	SEQRES CGYNIPQTDES
CC	ATOM   CGYN-------
CC	       ****       
SQ	SEQUENCE	411 AA;      MW;         CN;
	LPRETDEEPE EPGKKGSFVE MVDNLRGKSG QGYYVEMTVG SPPQTLNILV DTGSSNFAVG
	AAPHPFLHRY YQRQLSSTYR DLRKGVYVPY TQGKWEGELG TDLVSIPHGP NVTVRANIAA
	ITESDKFFIN GSNWEGILGL AYAEIARPDD SLEPFFDSLV KQTHVPNLFS LQLCGAGFPL
	NQSEVLASVG GSMIIGGIDH SLYTGSLWYT PIRREWYYEV IIVRVEINGQ DLKMDCKEYN
	YDKSIVDSGT TNLRLPKKVF EAAVKSIKAA SSTEKFPDGF WLGEQLVCWQ AGTTPWNIFP
	VISLYLMGEV TNQSFRITIL PQQYLRPVED VATSQDDCYK FAISQSSTGT VMGAVIMEGF
	YVVFDRARKR IGFAVSACHV HDEFRTAAVE GPFVTLDMED CGYNIPQTDE S
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