ID	5HESA	STANDARD;	PRT;	307	AA.
DT	CONVERTED FROM PDB (SEQRES) 5HES
DE	Mitogen-activated protein kinase kinase kinase MLT
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.140
CC	R-Factor	0.180
FT	#SUB	18	  20 	GLU	A	279	 281 	ALA	B	Protein	S	1
FT	#SUB	21	  23 	GLY	A	286	 288 	GLU	B	Protein	B	3
FT	#SUB	22	  24 	GLY	A	286	 288 	GLU	B	Protein	B	3
FT	#SUB	22	  24 	GLY	A	287	 289 	ALA	B	Protein	B	3
FT	#SUB	22	  24 	GLY	A	290	 292 	GLU	B	Protein	B	1
FT	#SUB	24	  26 	SER	A	290	 292 	GLU	B	Protein	A	6
FT	#SUB	93	  95 	ASN	A	205	 207 	LYS	B	Protein	B	1
FT	#SUB	94	  96 	SER	A	205	 207 	LYS	B	Protein	B	1
FT	#SUB	95	  97 	ASN	A	89	  91 	TYR	B	Protein	S	3
FT	#SUB	95	  97 	ASN	A	93	  95 	ASN	B	Protein	S	6
FT	#SUB	206	 208 	GLY	A	208	 210 	GLU	B	Protein	B	1
FT	#SUB	279	 281 	ALA	A	22	  24 	GLY	B	Protein	S	1
FT	#SUB	279	 281 	ALA	A	23	  25 	GLY	B	Protein	S	1
FT	#HET	21	  23 	GLY	A	1	401 	032	A	B	2
FT	#HET	25	  27 	PHE	A	1	401 	032	A	S	5
FT	#HET	28	  30 	VAL	A	1	401 	032	A	S	4
FT	#HET	41	  43 	ALA	A	1	401 	032	A	A	5
FT	#HET	42	  44 	VAL	A	1	401 	032	A	B	2
FT	#HET	43	  45 	LYS	A	1	401 	032	A	A	4
FT	#HET	61	  63 	ARG	A	2	402 	EDO	A	A	4
FT	#HET	64	  66 	ILE	A	1	401 	032	A	A	6
FT	#HET	66	  68 	PHE	A	1	401 	032	A	S	1
FT	#HET	78	  80 	ILE	A	1	401 	032	A	A	3
FT	#HET	80	  82 	THR	A	1	401 	032	A	S	7
FT	#HET	81	  83 	GLU	A	1	401 	032	A	B	4
FT	#HET	82	  84 	TYR	A	1	401 	032	A	A	8
FT	#HET	83	  85 	ALA	A	1	401 	032	A	A	7
FT	#HET	87	  89 	SER	A	1	401 	032	A	S	1
FT	#HET	90	  92 	ASP	A	1	401 	032	A	S	1
FT	#HET	138	 140 	VAL	A	1	401 	032	A	S	1
FT	#HET	142	 144 	ASP	A	2	402 	EDO	A	S	4
FT	#HET	144	 146 	VAL	A	2	402 	EDO	A	S	3
FT	#HET	146	 148 	LYS	A	2	402 	EDO	A	S	4
FT	#HET	148	 150 	CYS	A	1	401 	032	A	A	3
FT	#HET	149	 151 	ASP	A	1	401 	032	A	A	11
FT	#HET	150	 152 	PHE	A	1	401 	032	A	A	7
FT	#HET	151	 153 	GLY	A	1	401 	032	A	B	2
FT	DISORDER	1	3
FT	DISORDER	160	165
FT	DISORDER	298	307
CC	SEQUENCE	288 AA (ATOM);
CC	ASFVQIKFDD LQFFENCGGG SFGSVYRAKW ISQDKEVAVK KLLKIEKEAE ILSVLSHRNI
CC	IQFYGVILEP PNYGIVTEYA SLGSLYDYIN SNRSEEMDMD HIMTWATDVA KGMHYLHMEA
CC	PVKVIHRDLK SRNVVIAADG VLKICDFGAS RFHNHXGTFP WMAPEVIQSL PVSETCDTYS
CC	YGVVLWEMLT REVPFKGLEG LQVAWLVVEK NERLTIPSSC PRSFAELLHQ CWEADAKKRP
CC	SFKQIISILE SMSNDTSLPD KCNSFLHNKA EWRCEIEATL ERLKKLER
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES SMGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEK
CC	ATOM   ---ASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEK
CC	          ***********************************************
CC	SEQRES EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEM
CC	ATOM   EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEM
CC	       **************************************************
CC	SEQRES DMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDF
CC	ATOM   DMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDF
CC	       **************************************************
CC	SEQRES GASRFHNHXTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTR
CC	ATOM   GASRFHNHX------GTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTR
CC	       *********      ***********************************
CC	SEQRES EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPS
CC	ATOM   EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPS
CC	       **************************************************
CC	SEQRES FKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLS
CC	ATOM   FKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLER---
CC	       ***********************************************   
CC	SEQRES FKEQELK
CC	ATOM   -------
CC	              
SQ	SEQUENCE	307 AA;      MW;         CN;
	SMGASFVQIK FDDLQFFENC GGGSFGSVYR AKWISQDKEV AVKKLLKIEK EAEILSVLSH
	RNIIQFYGVI LEPPNYGIVT EYASLGSLYD YINSNRSEEM DMDHIMTWAT DVAKGMHYLH
	MEAPVKVIHR DLKSRNVVIA ADGVLKICDF GASRFHNHXT HMSLVGTFPW MAPEVIQSLP
	VSETCDTYSY GVVLWEMLTR EVPFKGLEGL QVAWLVVEKN ERLTIPSSCP RSFAELLHQC
	WEADAKKRPS FKQIISILES MSNDTSLPDK CNSFLHNKAE WRCEIEATLE RLKKLERDLS
	FKEQELK
//
ID	5HESB	STANDARD;	PRT;	307	AA.
DT	CONVERTED FROM PDB (SEQRES) 5HES
DE	Mitogen-activated protein kinase kinase kinase MLT
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.140
CC	R-Factor	0.180
FT	#SUB	22	  24 	GLY	B	279	 281 	ALA	A	Protein	B	1
FT	#SUB	23	  25 	GLY	B	279	 281 	ALA	A	Protein	B	1
FT	#SUB	89	  91 	TYR	B	95	  97 	ASN	A	Protein	S	3
FT	#SUB	93	  95 	ASN	B	95	  97 	ASN	A	Protein	A	6
FT	#SUB	205	 207 	LYS	B	93	  95 	ASN	A	Protein	S	1
FT	#SUB	205	 207 	LYS	B	94	  96 	SER	A	Protein	S	1
FT	#SUB	208	 210 	GLU	B	206	 208 	GLY	A	Protein	S	1
FT	#SUB	279	 281 	ALA	B	18	  20 	GLU	A	Protein	B	1
FT	#SUB	286	 288 	GLU	B	21	  23 	GLY	A	Protein	S	3
FT	#SUB	286	 288 	GLU	B	22	  24 	GLY	A	Protein	A	3
FT	#SUB	287	 289 	ALA	B	22	  24 	GLY	A	Protein	A	3
FT	#SUB	290	 292 	GLU	B	22	  24 	GLY	A	Protein	S	1
FT	#SUB	290	 292 	GLU	B	24	  26 	SER	A	Protein	S	6
FT	#HET	20	  22 	CYS	B	3	401 	032	B	S	1
FT	#HET	21	  23 	GLY	B	3	401 	032	B	B	2
FT	#HET	25	  27 	PHE	B	3	401 	032	B	S	5
FT	#HET	28	  30 	VAL	B	3	401 	032	B	S	3
FT	#HET	41	  43 	ALA	B	3	401 	032	B	A	5
FT	#HET	42	  44 	VAL	B	3	401 	032	B	B	1
FT	#HET	43	  45 	LYS	B	3	401 	032	B	A	8
FT	#HET	61	  63 	ARG	B	4	402 	EDO	B	S	2
FT	#HET	64	  66 	ILE	B	3	401 	032	B	A	6
FT	#HET	78	  80 	ILE	B	3	401 	032	B	A	3
FT	#HET	80	  82 	THR	B	3	401 	032	B	S	7
FT	#HET	81	  83 	GLU	B	3	401 	032	B	B	4
FT	#HET	82	  84 	TYR	B	3	401 	032	B	A	9
FT	#HET	83	  85 	ALA	B	3	401 	032	B	A	7
FT	#HET	86	  88 	GLY	B	3	401 	032	B	B	1
FT	#HET	90	  92 	ASP	B	3	401 	032	B	S	1
FT	#HET	142	 144 	ASP	B	4	402 	EDO	B	S	4
FT	#HET	144	 146 	VAL	B	4	402 	EDO	B	S	5
FT	#HET	146	 148 	LYS	B	4	402 	EDO	B	S	4
FT	#HET	148	 150 	CYS	B	3	401 	032	B	S	2
FT	#HET	149	 151 	ASP	B	3	401 	032	B	B	9
FT	#HET	150	 152 	PHE	B	3	401 	032	B	A	7
FT	#HET	151	 153 	GLY	B	3	401 	032	B	B	3
FT	#HET	286	 288 	GLU	B	1	401 	032	A	S	1
FT	DISORDER	1	4
FT	DISORDER	152	165
FT	DISORDER	297	307
CC	SEQUENCE	278 AA (ATOM);
CC	SFVQIKFDDL QFFENCGGGS FGSVYRAKWI SQDKEVAVKK LLKIEKEAEI LSVLSHRNII
CC	QFYGVILEPP NYGIVTEYAS LGSLYDYINS NRSEEMDMDH IMTWATDVAK GMHYLHMEAP
CC	VKVIHRDLKS RNVVIAADGV LKICDFGGTF PWMAPEVIQS LPVSETCDTY SYGVVLWEML
CC	TREVPFKGLE GLQVAWLVVE KNERLTIPSS CPRSFAELLH QCWEADAKKR PSFKQIISIL
CC	ESMSNDTSLP DKCNSFLHNK AEWRCEIEAT LERLKKLE
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES SMGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEK
CC	ATOM   ----SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEK
CC	           **********************************************
CC	SEQRES EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEM
CC	ATOM   EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEM
CC	       **************************************************
CC	SEQRES DMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDF
CC	ATOM   DMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDF
CC	       **************************************************
CC	SEQRES GASRFHNHXTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTR
CC	ATOM   G--------------GTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTR
CC	       *              ***********************************
CC	SEQRES EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPS
CC	ATOM   EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPS
CC	       **************************************************
CC	SEQRES FKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLS
CC	ATOM   FKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLE----
CC	       **********************************************    
CC	SEQRES FKEQELK
CC	ATOM   -------
CC	              
SQ	SEQUENCE	307 AA;      MW;         CN;
	SMGASFVQIK FDDLQFFENC GGGSFGSVYR AKWISQDKEV AVKKLLKIEK EAEILSVLSH
	RNIIQFYGVI LEPPNYGIVT EYASLGSLYD YINSNRSEEM DMDHIMTWAT DVAKGMHYLH
	MEAPVKVIHR DLKSRNVVIA ADGVLKICDF GASRFHNHXT HMSLVGTFPW MAPEVIQSLP
	VSETCDTYSY GVVLWEMLTR EVPFKGLEGL QVAWLVVEKN ERLTIPSSCP RSFAELLHQC
	WEADAKKRPS FKQIISILES MSNDTSLPDK CNSFLHNKAE WRCEIEATLE RLKKLERDLS
	FKEQELK
//