ID 5EAFA STANDARD; PRT; 539 AA. DT CONVERTED FROM PDB (SEQRES) 5EAF DE Lanosterol 14-alpha demethylase OS Saccharomyces cerevisiae CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.650 CC R-Factor 0.212 FT #SUB 335 335 ASP A 441 441 VAL B Protein A 3 FT #SUB 338 338 GLN A 439 439 TYR B Protein S 1 FT #SUB 338 338 GLN A 457 457 SER B Protein S 2 FT #SUB 338 338 GLN A 458 458 SER B Protein S 5 FT #SUB 338 338 GLN A 459 459 PRO B Protein S 2 FT #SUB 341 341 TYR A 418 418 GLU B Protein S 4 FT #SUB 341 341 TYR A 419 419 TYR B Protein S 1 FT #SUB 342 342 GLU A 107 107 LYS B Protein S 7 FT #SUB 342 342 GLU A 419 419 TYR B Protein S 1 FT #SUB 345 345 MET A 418 418 GLU B Protein S 1 FT #SUB 524 524 ARG A 421 421 PRO B Protein B 2 FT #SUB 525 525 ASN A 421 421 PRO B Protein A 7 FT #HET 113 113 PHE A 1 601 HEM A S 1 FT #HET 126 126 TYR A 1 601 HEM A S 3 FT #HET 126 126 TYR A 2 602 FQC A S 6 FT #HET 129 129 LEU A 2 602 FQC A S 1 FT #HET 130 130 THR A 2 602 FQC A S 1 FT #HET 134 134 PHE A 2 602 FQC A S 3 FT #HET 139 139 ILE A 2 602 FQC A S 1 FT #HET 140 140 TYR A 1 601 HEM A S 5 FT #HET 140 140 TYR A 2 602 FQC A S 2 FT #HET 147 147 LEU A 1 601 HEM A S 4 FT #HET 151 151 LYS A 1 601 HEM A S 6 FT #HET 236 236 PHE A 2 602 FQC A S 1 FT #HET 241 241 PHE A 2 602 FQC A S 1 FT #HET 310 310 GLY A 2 602 FQC A B 4 FT #HET 311 311 VAL A 1 601 HEM A A 3 FT #HET 311 311 VAL A 2 602 FQC A B 1 FT #HET 314 314 GLY A 2 602 FQC A B 10 FT #HET 315 315 GLY A 1 601 HEM A B 2 FT #HET 318 318 THR A 1 601 HEM A S 7 FT #HET 318 318 THR A 2 602 FQC A S 1 FT #HET 322 322 THR A 1 601 HEM A S 1 FT #HET 374 374 LEU A 1 601 HEM A S 2 FT #HET 378 378 HIS A 1 601 HEM A S 1 FT #HET 379 379 PRO A 1 601 HEM A S 2 FT #HET 380 380 LEU A 2 602 FQC A S 6 FT #HET 383 383 LEU A 1 601 HEM A S 7 FT #HET 383 383 LEU A 2 602 FQC A S 1 FT #HET 385 385 ARG A 1 601 HEM A S 8 FT #HET 462 462 PRO A 1 601 HEM A B 3 FT #HET 463 463 PHE A 1 601 HEM A A 9 FT #HET 464 464 GLY A 1 601 HEM A B 1 FT #HET 468 468 HIS A 1 601 HEM A A 24 FT #HET 469 469 ARG A 1 601 HEM A B 1 FT #HET 470 470 CYS A 1 601 HEM A A 24 FT #HET 471 471 ILE A 1 601 HEM A S 1 FT #HET 472 472 GLY A 1 601 HEM A B 3 FT #HET 475 475 PHE A 1 601 HEM A S 1 FT #HET 476 476 ALA A 1 601 HEM A S 1 FT #HET 509 509 MET A 2 602 FQC A S 1 FT DISORDER 1 7 FT DISORDER 536 539 CC SEQUENCE 528 AA (ATOM); CC VGEALEYVNI GLSHFLALPL AQRISLIIII PFIYNIVWQL LYSLRKDRPP LVFYWIPWVG CC SAVVYGMKPY EFFEECQKKY GDIFSFVLLG RVMTVYLGPK GHEFVFNAKL ADVSAEAAYA CC HLTTPVFGKG VIYDCPNSRL MEQKKFVKGA LTKEAFKSYV PLIAEEVYKY FRDSKNFRLN CC ERTTGTIDVM VTQPEMTIFT ASRSLLGKEM RAKLDTDFAY LYSDLDKGFT PINFVFPNLP CC LEHYRKRDHA QKAISGTYMS LIKERRKNND IQDRDLIDSL MKNSTYKDGV KMTDQEIANL CC LIGVLMGGQH TSAATSAWIL LHLAERPDVQ QELYEEQMRV LDGGKKELTY DLLQEMPLLN CC QTIKETLRMH HPLHSLFRKV MKDMHVPNTS YAIPAGYHVL VSPGYTHLRD EYFPNAHQFN CC IHRWNNDSAS SYSVGEEVDY GFGAISKGVS SPYLPFGGGR HRCIGEHFAY CQLGVLMSIF CC IRTLKWHYPE GKTVPPPDFT SMVTLPTGPA KIIWEKRNPE QKIGGRHH CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MSATKSIVGEALEYVNIGLSHFLALPLAQRISLIIIIPFIYNIVWQLLYS CC ATOM -------VGEALEYVNIGLSHFLALPLAQRISLIIIIPFIYNIVWQLLYS CC ******************************************* CC SEQRES LRKDRPPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVM CC ATOM LRKDRPPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVM CC ************************************************** CC SEQRES TVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQ CC ATOM TVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQ CC ************************************************** CC SEQRES KKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQ CC ATOM KKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQ CC ************************************************** CC SEQRES PEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEH CC ATOM PEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEH CC ************************************************** CC SEQRES YRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMT CC ATOM YRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMT CC ************************************************** CC SEQRES DQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDG CC ATOM DQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDG CC ************************************************** CC SEQRES GKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYAI CC ATOM GKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYAI CC ************************************************** CC SEQRES PAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFG CC ATOM PAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFG CC ************************************************** CC SEQRES AISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKT CC ATOM AISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKT CC ************************************************** CC SEQRES VPPPDFTSMVTLPTGPAKIIWEKRNPEQKIGGRHHHHHH CC ATOM VPPPDFTSMVTLPTGPAKIIWEKRNPEQKIGGRHH---- CC *********************************** SQ SEQUENCE 539 AA; MW; CN; MSATKSIVGE ALEYVNIGLS HFLALPLAQR ISLIIIIPFI YNIVWQLLYS LRKDRPPLVF YWIPWVGSAV VYGMKPYEFF EECQKKYGDI FSFVLLGRVM TVYLGPKGHE FVFNAKLADV SAEAAYAHLT TPVFGKGVIY DCPNSRLMEQ KKFVKGALTK EAFKSYVPLI AEEVYKYFRD SKNFRLNERT TGTIDVMVTQ PEMTIFTASR SLLGKEMRAK LDTDFAYLYS DLDKGFTPIN FVFPNLPLEH YRKRDHAQKA ISGTYMSLIK ERRKNNDIQD RDLIDSLMKN STYKDGVKMT DQEIANLLIG VLMGGQHTSA ATSAWILLHL AERPDVQQEL YEEQMRVLDG GKKELTYDLL QEMPLLNQTI KETLRMHHPL HSLFRKVMKD MHVPNTSYAI PAGYHVLVSP GYTHLRDEYF PNAHQFNIHR WNNDSASSYS VGEEVDYGFG AISKGVSSPY LPFGGGRHRC IGEHFAYCQL GVLMSIFIRT LKWHYPEGKT VPPPDFTSMV TLPTGPAKII WEKRNPEQKI GGRHHHHHH // ID 5EAFB STANDARD; PRT; 539 AA. DT CONVERTED FROM PDB (SEQRES) 5EAF DE Lanosterol 14-alpha demethylase OS Saccharomyces cerevisiae CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.650 CC R-Factor 0.212 FT #SUB 107 107 LYS B 342 342 GLU A Protein S 7 FT #SUB 418 418 GLU B 341 341 TYR A Protein B 4 FT #SUB 418 418 GLU B 345 345 MET A Protein S 1 FT #SUB 419 419 TYR B 341 341 TYR A Protein S 1 FT #SUB 419 419 TYR B 342 342 GLU A Protein S 1 FT #SUB 421 421 PRO B 524 524 ARG A Protein S 2 FT #SUB 421 421 PRO B 525 525 ASN A Protein S 7 FT #SUB 439 439 TYR B 338 338 GLN A Protein S 1 FT #SUB 441 441 VAL B 335 335 ASP A Protein S 3 FT #SUB 457 457 SER B 338 338 GLN A Protein B 2 FT #SUB 458 458 SER B 338 338 GLN A Protein B 5 FT #SUB 459 459 PRO B 338 338 GLN A Protein S 2 FT #HET 113 113 PHE B 3 601 HEM B S 1 FT #HET 126 126 TYR B 3 601 HEM B S 4 FT #HET 126 126 TYR B 4 602 FQC B S 8 FT #HET 129 129 LEU B 4 602 FQC B S 1 FT #HET 130 130 THR B 4 602 FQC B S 1 FT #HET 134 134 PHE B 4 602 FQC B S 4 FT #HET 139 139 ILE B 4 602 FQC B S 1 FT #HET 140 140 TYR B 3 601 HEM B S 5 FT #HET 140 140 TYR B 4 602 FQC B S 2 FT #HET 147 147 LEU B 3 601 HEM B S 4 FT #HET 151 151 LYS B 3 601 HEM B S 6 FT #HET 236 236 PHE B 4 602 FQC B S 2 FT #HET 241 241 PHE B 4 602 FQC B S 1 FT #HET 310 310 GLY B 4 602 FQC B B 4 FT #HET 311 311 VAL B 3 601 HEM B A 4 FT #HET 311 311 VAL B 4 602 FQC B B 1 FT #HET 314 314 GLY B 4 602 FQC B B 9 FT #HET 315 315 GLY B 3 601 HEM B B 2 FT #HET 318 318 THR B 3 601 HEM B S 7 FT #HET 322 322 THR B 3 601 HEM B S 1 FT #HET 374 374 LEU B 3 601 HEM B S 2 FT #HET 378 378 HIS B 3 601 HEM B S 2 FT #HET 379 379 PRO B 3 601 HEM B S 2 FT #HET 380 380 LEU B 3 601 HEM B S 1 FT #HET 380 380 LEU B 4 602 FQC B S 6 FT #HET 383 383 LEU B 3 601 HEM B S 13 FT #HET 385 385 ARG B 3 601 HEM B S 8 FT #HET 462 462 PRO B 3 601 HEM B B 3 FT #HET 463 463 PHE B 3 601 HEM B A 9 FT #HET 464 464 GLY B 3 601 HEM B B 1 FT #HET 468 468 HIS B 3 601 HEM B A 22 FT #HET 469 469 ARG B 3 601 HEM B B 1 FT #HET 470 470 CYS B 3 601 HEM B A 24 FT #HET 471 471 ILE B 3 601 HEM B S 1 FT #HET 472 472 GLY B 3 601 HEM B B 7 FT #HET 475 475 PHE B 3 601 HEM B S 1 FT #HET 476 476 ALA B 3 601 HEM B S 1 FT DISORDER 1 6 FT DISORDER 535 539 CC SEQUENCE 528 AA (ATOM); CC IVGEALEYVN IGLSHFLALP LAQRISLIII IPFIYNIVWQ LLYSLRKDRP PLVFYWIPWV CC GSAVVYGMKP YEFFEECQKK YGDIFSFVLL GRVMTVYLGP KGHEFVFNAK LADVSAEAAY CC AHLTTPVFGK GVIYDCPNSR LMEQKKFVKG ALTKEAFKSY VPLIAEEVYK YFRDSKNFRL CC NERTTGTIDV MVTQPEMTIF TASRSLLGKE MRAKLDTDFA YLYSDLDKGF TPINFVFPNL CC PLEHYRKRDH AQKAISGTYM SLIKERRKNN DIQDRDLIDS LMKNSTYKDG VKMTDQEIAN CC LLIGVLMGGQ HTSAATSAWI LLHLAERPDV QQELYEEQMR VLDGGKKELT YDLLQEMPLL CC NQTIKETLRM HHPLHSLFRK VMKDMHVPNT SYAIPAGYHV LVSPGYTHLR DEYFPNAHQF CC NIHRWNNDSA SSYSVGEEVD YGFGAISKGV SSPYLPFGGG RHRCIGEHFA YCQLGVLMSI CC FIRTLKWHYP EGKTVPPPDF TSMVTLPTGP AKIIWEKRNP EQKIGGRH CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MSATKSIVGEALEYVNIGLSHFLALPLAQRISLIIIIPFIYNIVWQLLYS CC ATOM ------IVGEALEYVNIGLSHFLALPLAQRISLIIIIPFIYNIVWQLLYS CC ******************************************** CC SEQRES LRKDRPPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVM CC ATOM LRKDRPPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVM CC ************************************************** CC SEQRES TVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQ CC ATOM TVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQ CC ************************************************** CC SEQRES KKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQ CC ATOM KKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQ CC ************************************************** CC SEQRES PEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEH CC ATOM PEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEH CC ************************************************** CC SEQRES YRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMT CC ATOM YRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMT CC ************************************************** CC SEQRES DQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDG CC ATOM DQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDG CC ************************************************** CC SEQRES GKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYAI CC ATOM GKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYAI CC ************************************************** CC SEQRES PAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFG CC ATOM PAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFG CC ************************************************** CC SEQRES AISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKT CC ATOM AISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKT CC ************************************************** CC SEQRES VPPPDFTSMVTLPTGPAKIIWEKRNPEQKIGGRHHHHHH CC ATOM VPPPDFTSMVTLPTGPAKIIWEKRNPEQKIGGRH----- CC ********************************** SQ SEQUENCE 539 AA; MW; CN; MSATKSIVGE ALEYVNIGLS HFLALPLAQR ISLIIIIPFI YNIVWQLLYS LRKDRPPLVF YWIPWVGSAV VYGMKPYEFF EECQKKYGDI FSFVLLGRVM TVYLGPKGHE FVFNAKLADV SAEAAYAHLT TPVFGKGVIY DCPNSRLMEQ KKFVKGALTK EAFKSYVPLI AEEVYKYFRD SKNFRLNERT TGTIDVMVTQ PEMTIFTASR SLLGKEMRAK LDTDFAYLYS DLDKGFTPIN FVFPNLPLEH YRKRDHAQKA ISGTYMSLIK ERRKNNDIQD RDLIDSLMKN STYKDGVKMT DQEIANLLIG VLMGGQHTSA ATSAWILLHL AERPDVQQEL YEEQMRVLDG GKKELTYDLL QEMPLLNQTI KETLRMHHPL HSLFRKVMKD MHVPNTSYAI PAGYHVLVSP GYTHLRDEYF PNAHQFNIHR WNNDSASSYS VGEEVDYGFG AISKGVSSPY LPFGGGRHRC IGEHFAYCQL GVLMSIFIRT LKWHYPEGKT VPPPDFTSMV TLPTGPAKII WEKRNPEQKI GGRHHHHHH //