ID 5BTRA STANDARD; PRT; 397 AA. DT CONVERTED FROM PDB (SEQRES) 5BTR DE NAD-dependent protein deacetylase sirtuin-1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 3.200 CC R-Factor 0.209 FT #SUB 4 144 ASP A 78 218 MET B Protein S 1 FT #SUB 5 145 ASN A 78 218 MET B Protein B 2 FT #SUB 6 146 LEU A 45 185 TYR B Protein A 4 FT #SUB 6 146 LEU A 48 188 VAL B Protein S 3 FT #SUB 6 146 LEU A 49 189 GLN B Protein S 1 FT #SUB 6 146 LEU A 52 192 LEU B Protein S 3 FT #SUB 6 146 LEU A 78 218 MET B Protein A 2 FT #SUB 6 146 LEU A 81 221 TRP B Protein S 1 FT #SUB 8 148 PHE A 82 222 GLN B Protein S 7 FT #SUB 11 151 GLU A 45 185 TYR B Protein S 4 FT #SUB 34 174 SER A 283 423 HIS B Protein S 2 FT #SUB 34 174 SER A 284 424 ARG B Protein S 2 FT #SUB 34 174 SER A 287 427 LYS B Protein A 4 FT #SUB 35 175 ASP A 287 427 LYS B Protein A 8 FT #SUB 36 176 TRP A 282 422 PHE B Protein S 4 FT #SUB 36 176 TRP A 283 423 HIS B Protein S 7 FT #SUB 36 176 TRP A 286 426 MET B Protein S 4 FT #SUB 36 176 TRP A 290 430 LYS B Protein B 2 FT #SUB 36 176 TRP A 307 447 PRO B Protein S 1 FT #SUB 36 176 TRP A 314 454 SER B Protein A 4 FT #SUB 37 177 THR A 314 454 SER B Protein S 2 FT #SUB 39 179 ARG A 15 155 ASN B Protein B 1 FT #SUB 40 180 PRO A 15 155 ASN B Protein B 1 FT #SUB 40 180 PRO A 45 185 TYR B Protein S 1 FT #SUB 40 180 PRO A 89 229 SER B Protein S 1 FT #SUB 41 181 ARG A 15 155 ASN B Protein A 6 FT #SUB 42 182 ILE A 45 185 TYR B Protein S 2 FT #SUB 46 186 THR A 45 185 TYR B Protein S 1 FT #SUB 46 186 THR A 46 186 THR B Protein S 2 FT #SUB 46 186 THR A 49 189 GLN B Protein A 3 FT #SUB 50 190 GLN A 49 189 GLN B Protein A 6 FT #SUB 53 193 MET A 52 192 LEU B Protein S 1 FT #SUB 45 185 TYR A 6 146 LEU C Protein S 4 FT #SUB 45 185 TYR A 7 147 LEU C Protein S 1 FT #SUB 45 185 TYR A 11 151 GLU C Protein S 4 FT #SUB 45 185 TYR A 40 180 PRO C Protein S 1 FT #SUB 45 185 TYR A 42 182 ILE C Protein S 3 FT #SUB 45 185 TYR A 46 186 THR C Protein S 1 FT #SUB 48 188 VAL A 6 146 LEU C Protein S 2 FT #SUB 49 189 GLN A 50 190 GLN C Protein S 5 FT #SUB 49 189 GLN A 53 193 MET C Protein S 5 FT #SUB 52 192 LEU A 6 146 LEU C Protein S 1 FT #SUB 52 192 LEU A 53 193 MET C Protein S 1 FT #SUB 78 218 MET A 5 145 ASN C Protein S 2 FT #SUB 78 218 MET A 6 146 LEU C Protein S 3 FT #SUB 82 222 GLN A 8 148 PHE C Protein S 7 FT #SUB 85 225 ILE A 6 146 LEU C Protein S 1 FT #SUB 282 422 PHE A 36 176 TRP C Protein S 2 FT #SUB 283 423 HIS A 35 175 ASP C Protein S 1 FT #SUB 283 423 HIS A 36 176 TRP C Protein A 8 FT #SUB 286 426 MET A 36 176 TRP C Protein S 6 FT #SUB 287 427 LYS A 35 175 ASP C Protein S 14 FT #SUB 290 430 LYS A 35 175 ASP C Protein S 1 FT #SUB 290 430 LYS A 36 176 TRP C Protein S 1 FT #SUB 307 447 PRO A 36 176 TRP C Protein B 1 FT #SUB 314 454 SER A 36 176 TRP C Protein S 3 FT #SUB 45 185 TYR A 2 1 ARG D Protein S 1 FT #SUB 66 206 LEU A 5 4 FDL D Protein S 1 FT #SUB 69 209 THR A 5 4 FDL D Protein S 3 FT #SUB 82 222 GLN A 2 1 ARG D Protein S 2 FT #SUB 86 226 ASN A 2 1 ARG D Protein S 5 FT #SUB 134 274 ARG A 5 4 FDL D Protein S 5 FT #SUB 157 297 PHE A 5 4 FDL D Protein S 2 FT #SUB 223 363 HIS A 5 4 FDL D Protein S 11 FT #SUB 272 412 VAL A 5 4 FDL D Protein A 7 FT #SUB 273 413 PHE A 5 4 FDL D Protein B 3 FT #SUB 274 414 PHE A 5 4 FDL D Protein A 6 FT #SUB 275 415 GLY A 4 3 LYS D Protein B 2 FT #SUB 275 415 GLY A 5 4 FDL D Protein B 2 FT #SUB 276 416 GLU A 4 3 LYS D Protein B 3 FT #SUB 276 416 GLU A 5 4 FDL D Protein B 3 FT #SUB 277 417 ASN A 1 0 ACE D Protein S 2 FT #SUB 277 417 ASN A 4 3 LYS D Protein S 3 FT #SUB 278 418 LEU A 5 4 FDL D Protein S 3 FT #SUB 283 423 HIS A 3 2 HIS D Protein S 1 FT #SUB 304 444 LYS A 5 4 FDL D Protein B 1 FT #SUB 305 445 VAL A 5 4 FDL D Protein S 3 FT #SUB 306 446 ARG A 4 3 LYS D Protein B 1 FT #SUB 306 446 ARG A 5 4 FDL D Protein B 7 FT #SUB 307 447 PRO A 4 3 LYS D Protein S 1 FT #SUB 8 148 PHE A 1 0 ACE E Protein S 5 FT #SUB 8 148 PHE A 2 1 ARG E Protein S 2 FT #SUB 10 150 ASP A 2 1 ARG E Protein S 7 FT #SUB 37 177 THR A 3 2 HIS E Protein S 2 FT #SUB 40 180 PRO A 2 1 ARG E Protein S 6 FT #HET 62 202 LEU A 9 101 STL D S 1 FT #HET 66 206 LEU A 9 101 STL D S 2 FT #HET 69 209 THR A 2 702 STL A S 3 FT #HET 70 210 ILE A 9 101 STL D B 1 FT #HET 71 211 PRO A 9 101 STL D A 5 FT #HET 72 212 PRO A 2 702 STL A S 4 FT #HET 72 212 PRO A 10 102 STL D S 1 FT #HET 74 214 GLU A 10 102 STL D S 2 FT #HET 75 215 LEU A 10 102 STL D S 3 FT #HET 79 219 THR A 10 102 STL D S 1 FT #HET 82 222 GLN A 10 102 STL D S 5 FT #HET 83 223 ILE A 9 101 STL D S 5 FT #HET 83 223 ILE A 10 102 STL D S 1 FT #HET 86 226 ASN A 9 101 STL D A 6 FT #HET 86 226 ASN A 10 102 STL D S 4 FT #HET 90 230 GLU A 9 101 STL D S 5 FT #HET 152 292 ASP A 2 702 STL A S 5 FT #HET 154 294 GLN A 2 702 STL A S 5 FT #HET 155 295 ALA A 2 702 STL A A 5 FT #HET 158 298 ASP A 2 702 STL A S 6 FT #HET 158 298 ASP A 10 102 STL D S 2 FT #HET 160 300 GLU A 10 102 STL D S 1 FT #HET 231 371 CYS A 1 701 ZN A S 2 FT #HET 234 374 CYS A 1 701 ZN A A 3 FT #HET 255 395 CYS A 1 701 ZN A S 2 FT #HET 258 398 CYS A 1 701 ZN A A 4 FT #HET 274 414 PHE A 2 702 STL A S 1 FT #HET 274 414 PHE A 10 102 STL D A 6 FT #HET 275 415 GLY A 10 102 STL D B 6 FT #HET 304 444 LYS A 2 702 STL A A 3 FT #HET 305 445 VAL A 2 702 STL A S 1 FT #HET 306 446 ARG A 9 101 STL D S 5 FT #HET 307 447 PRO A 9 101 STL D A 4 FT #HET 310 450 LEU A 9 101 STL D S 1 FT DISORDER 1 3 FT DISORDER 17 33 FT DISORDER 391 397 CC SEQUENCE 370 AA (ATOM); CC DNLLFGDEII TNGSDWTPRP RIGPYTFVQQ HLMIGTDPRT ILKDLLPETI PPPELDDMTL CC WQIVINILSE PPKRKKRKDI NTIEDAVKLL QESKKIIVLT GAGVSVSSGI PDFRSRDGIY CC ARLAVDFPDL PDPQAMFDIE YFRKDPRPFF KFAKEIYPGQ FQPSLCHKFI ALSDKEGKLL CC RNYTQNIDTL EQVAGIQRII QCHGSFATAS CLICKYKVDC EAVRGDIFNQ VVPRCPRCPA CC DEPLAIMKPE IVFFGENLPE QFHRAMKYDK DEVDLLIVIG SSLKVRPVAL IPSSIPHEVP CC QILINREPLP HLHFDVELLG DCDVIINELC HRLGGEYAKL SSNPVKLSEI TEQYLFLPPN CC RYIFHGAEVY CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTFVQQ CC ATOM ---DNLLFGDEIITNG-----------------SDWTPRPRIGPYTFVQQ CC ************* ***************** CC SEQRES HLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI CC ATOM HLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI CC ************************************************** CC SEQRES NTIEDAVKLLQESKKIIVLTGAGVSVSSGIPDFRSRDGIYARLAVDFPDL CC ATOM NTIEDAVKLLQESKKIIVLTGAGVSVSSGIPDFRSRDGIYARLAVDFPDL CC ************************************************** CC SEQRES PDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLL CC ATOM PDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLL CC ************************************************** CC SEQRES RNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQ CC ATOM RNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQ CC ************************************************** CC SEQRES VVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIG CC ATOM VVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIG CC ************************************************** CC SEQRES SSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELC CC ATOM SSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELC CC ************************************************** CC SEQRES HRLGGEYAKLSSNPVKLSEITEQYLFLPPNRYIFHGAEVYSDSEDDV CC ATOM HRLGGEYAKLSSNPVKLSEITEQYLFLPPNRYIFHGAEVY------- CC **************************************** SQ SEQUENCE 397 AA; MW; CN; GSRDNLLFGD EIITNGFHSC ESDEEDRASH ASSSDWTPRP RIGPYTFVQQ HLMIGTDPRT ILKDLLPETI PPPELDDMTL WQIVINILSE PPKRKKRKDI NTIEDAVKLL QESKKIIVLT GAGVSVSSGI PDFRSRDGIY ARLAVDFPDL PDPQAMFDIE YFRKDPRPFF KFAKEIYPGQ FQPSLCHKFI ALSDKEGKLL RNYTQNIDTL EQVAGIQRII QCHGSFATAS CLICKYKVDC EAVRGDIFNQ VVPRCPRCPA DEPLAIMKPE IVFFGENLPE QFHRAMKYDK DEVDLLIVIG SSLKVRPVAL IPSSIPHEVP QILINREPLP HLHFDVELLG DCDVIINELC HRLGGEYAKL SSNPVKLSEI TEQYLFLPPN RYIFHGAEVY SDSEDDV // ID 5BTRB STANDARD; PRT; 397 AA. DT CONVERTED FROM PDB (SEQRES) 5BTR DE NAD-dependent protein deacetylase sirtuin-1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 3.200 CC R-Factor 0.209 FT #SUB 15 155 ASN B 39 179 ARG A Protein S 1 FT #SUB 15 155 ASN B 40 180 PRO A Protein S 1 FT #SUB 15 155 ASN B 41 181 ARG A Protein A 6 FT #SUB 45 185 TYR B 6 146 LEU A Protein S 4 FT #SUB 45 185 TYR B 11 151 GLU A Protein S 4 FT #SUB 45 185 TYR B 40 180 PRO A Protein S 1 FT #SUB 45 185 TYR B 42 182 ILE A Protein S 2 FT #SUB 45 185 TYR B 46 186 THR A Protein S 1 FT #SUB 46 186 THR B 46 186 THR A Protein S 2 FT #SUB 48 188 VAL B 6 146 LEU A Protein S 3 FT #SUB 49 189 GLN B 6 146 LEU A Protein B 1 FT #SUB 49 189 GLN B 46 186 THR A Protein S 3 FT #SUB 49 189 GLN B 50 190 GLN A Protein S 6 FT #SUB 52 192 LEU B 6 146 LEU A Protein S 3 FT #SUB 52 192 LEU B 53 193 MET A Protein S 1 FT #SUB 78 218 MET B 4 144 ASP A Protein S 1 FT #SUB 78 218 MET B 5 145 ASN A Protein S 2 FT #SUB 78 218 MET B 6 146 LEU A Protein S 2 FT #SUB 81 221 TRP B 6 146 LEU A Protein S 1 FT #SUB 82 222 GLN B 8 148 PHE A Protein S 7 FT #SUB 89 229 SER B 40 180 PRO A Protein S 1 FT #SUB 282 422 PHE B 36 176 TRP A Protein S 4 FT #SUB 283 423 HIS B 34 174 SER A Protein B 2 FT #SUB 283 423 HIS B 36 176 TRP A Protein A 7 FT #SUB 284 424 ARG B 34 174 SER A Protein B 2 FT #SUB 286 426 MET B 36 176 TRP A Protein S 4 FT #SUB 287 427 LYS B 34 174 SER A Protein S 4 FT #SUB 287 427 LYS B 35 175 ASP A Protein S 8 FT #SUB 290 430 LYS B 36 176 TRP A Protein S 2 FT #SUB 307 447 PRO B 36 176 TRP A Protein B 1 FT #SUB 314 454 SER B 36 176 TRP A Protein S 4 FT #SUB 314 454 SER B 37 177 THR A Protein S 2 FT #SUB 3 143 ARG B 78 218 MET C Protein B 2 FT #SUB 4 144 ASP B 78 218 MET C Protein B 3 FT #SUB 5 145 ASN B 78 218 MET C Protein B 3 FT #SUB 6 146 LEU B 45 185 TYR C Protein A 2 FT #SUB 6 146 LEU B 48 188 VAL C Protein S 3 FT #SUB 6 146 LEU B 49 189 GLN C Protein S 1 FT #SUB 6 146 LEU B 52 192 LEU C Protein S 2 FT #SUB 6 146 LEU B 78 218 MET C Protein A 2 FT #SUB 6 146 LEU B 81 221 TRP C Protein S 1 FT #SUB 6 146 LEU B 85 225 ILE C Protein S 1 FT #SUB 7 147 LEU B 45 185 TYR C Protein S 1 FT #SUB 8 148 PHE B 82 222 GLN C Protein S 5 FT #SUB 11 151 GLU B 45 185 TYR C Protein S 6 FT #SUB 34 174 SER B 283 423 HIS C Protein A 3 FT #SUB 34 174 SER B 284 424 ARG C Protein S 3 FT #SUB 34 174 SER B 287 427 LYS C Protein A 3 FT #SUB 35 175 ASP B 287 427 LYS C Protein B 4 FT #SUB 36 176 TRP B 283 423 HIS C Protein S 5 FT #SUB 36 176 TRP B 286 426 MET C Protein S 8 FT #SUB 36 176 TRP B 287 427 LYS C Protein S 2 FT #SUB 36 176 TRP B 290 430 LYS C Protein B 3 FT #SUB 36 176 TRP B 307 447 PRO C Protein S 1 FT #SUB 36 176 TRP B 314 454 SER C Protein S 2 FT #SUB 37 177 THR B 314 454 SER C Protein S 2 FT #SUB 40 180 PRO B 45 185 TYR C Protein S 3 FT #SUB 42 182 ILE B 45 185 TYR C Protein S 3 FT #SUB 46 186 THR B 46 186 THR C Protein S 1 FT #SUB 50 190 GLN B 49 189 GLN C Protein S 4 FT #SUB 53 193 MET B 49 189 GLN C Protein S 4 FT #SUB 66 206 LEU B 5 4 FDL E Protein S 1 FT #SUB 72 212 PRO B 5 4 FDL E Protein S 1 FT #SUB 86 226 ASN B 2 1 ARG E Protein S 9 FT #SUB 157 297 PHE B 5 4 FDL E Protein S 2 FT #SUB 223 363 HIS B 5 4 FDL E Protein S 10 FT #SUB 272 412 VAL B 5 4 FDL E Protein A 7 FT #SUB 273 413 PHE B 5 4 FDL E Protein B 2 FT #SUB 274 414 PHE B 5 4 FDL E Protein A 7 FT #SUB 275 415 GLY B 4 3 LYS E Protein B 4 FT #SUB 275 415 GLY B 5 4 FDL E Protein B 3 FT #SUB 276 416 GLU B 4 3 LYS E Protein B 3 FT #SUB 276 416 GLU B 5 4 FDL E Protein B 4 FT #SUB 277 417 ASN B 4 3 LYS E Protein S 2 FT #SUB 278 418 LEU B 5 4 FDL E Protein S 3 FT #SUB 304 444 LYS B 5 4 FDL E Protein B 1 FT #SUB 305 445 VAL B 5 4 FDL E Protein S 3 FT #SUB 306 446 ARG B 4 3 LYS E Protein B 1 FT #SUB 306 446 ARG B 5 4 FDL E Protein B 7 FT #SUB 307 447 PRO B 3 2 HIS E Protein S 2 FT #SUB 307 447 PRO B 4 3 LYS E Protein S 1 FT #SUB 307 447 PRO B 5 4 FDL E Protein S 1 FT #SUB 8 148 PHE B 1 0 ACE F Protein S 3 FT #SUB 8 148 PHE B 2 1 ARG F Protein S 2 FT #SUB 10 150 ASP B 2 1 ARG F Protein S 7 FT #SUB 36 176 TRP B 3 2 HIS F Protein S 1 FT #SUB 37 177 THR B 3 2 HIS F Protein S 3 FT #SUB 40 180 PRO B 2 1 ARG F Protein S 2 FT #HET 66 206 LEU B 11 101 STL E S 2 FT #HET 71 211 PRO B 11 101 STL E A 4 FT #HET 72 212 PRO B 4 702 STL B S 1 FT #HET 72 212 PRO B 5 703 STL B S 2 FT #HET 75 215 LEU B 5 703 STL B S 3 FT #HET 79 219 THR B 5 703 STL B S 1 FT #HET 82 222 GLN B 5 703 STL B S 5 FT #HET 83 223 ILE B 5 703 STL B S 3 FT #HET 83 223 ILE B 11 101 STL E S 7 FT #HET 86 226 ASN B 5 703 STL B S 2 FT #HET 86 226 ASN B 11 101 STL E A 12 FT #HET 90 230 GLU B 11 101 STL E S 5 FT #HET 134 274 ARG B 4 702 STL B S 4 FT #HET 152 292 ASP B 4 702 STL B S 5 FT #HET 154 294 GLN B 4 702 STL B S 6 FT #HET 155 295 ALA B 4 702 STL B A 6 FT #HET 158 298 ASP B 4 702 STL B A 8 FT #HET 158 298 ASP B 5 703 STL B S 2 FT #HET 231 371 CYS B 3 701 ZN B S 2 FT #HET 234 374 CYS B 3 701 ZN B A 3 FT #HET 255 395 CYS B 3 701 ZN B S 2 FT #HET 258 398 CYS B 3 701 ZN B A 4 FT #HET 274 414 PHE B 4 702 STL B S 2 FT #HET 274 414 PHE B 5 703 STL B A 3 FT #HET 275 415 GLY B 5 703 STL B B 5 FT #HET 304 444 LYS B 4 702 STL B A 4 FT #HET 306 446 ARG B 11 101 STL E S 5 FT #HET 307 447 PRO B 11 101 STL E A 4 FT #HET 310 450 LEU B 11 101 STL E S 1 FT DISORDER 1 1 FT DISORDER 17 33 FT DISORDER 364 369 FT DISORDER 391 397 CC SEQUENCE 366 AA (ATOM); CC SRDNLLFGDE IITNGSDWTP RPRIGPYTFV QQHLMIGTDP RTILKDLLPE TIPPPELDDM CC TLWQIVINIL SEPPKRKKRK DINTIEDAVK LLQESKKIIV LTGAGVSVSS GIPDFRSRDG CC IYARLAVDFP DLPDPQAMFD IEYFRKDPRP FFKFAKEIYP GQFQPSLCHK FIALSDKEGK CC LLRNYTQNID TLEQVAGIQR IIQCHGSFAT ASCLICKYKV DCEAVRGDIF NQVVPRCPRC CC PADEPLAIMK PEIVFFGENL PEQFHRAMKY DKDEVDLLIV IGSSLKVRPV ALIPSSIPHE CC VPQILINREP LPHLHFDVEL LGDCDVIINE LCHRLGGEYA KLSSNITEQY LFLPPNRYIF CC HGAEVY CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTFVQQ CC ATOM -SRDNLLFGDEIITNG-----------------SDWTPRPRIGPYTFVQQ CC *************** ***************** CC SEQRES HLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI CC ATOM HLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI CC ************************************************** CC SEQRES NTIEDAVKLLQESKKIIVLTGAGVSVSSGIPDFRSRDGIYARLAVDFPDL CC ATOM NTIEDAVKLLQESKKIIVLTGAGVSVSSGIPDFRSRDGIYARLAVDFPDL CC ************************************************** CC SEQRES PDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLL CC ATOM PDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLL CC ************************************************** CC SEQRES RNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQ CC ATOM RNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQ CC ************************************************** CC SEQRES VVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIG CC ATOM VVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIG CC ************************************************** CC SEQRES SSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELC CC ATOM SSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELC CC ************************************************** CC SEQRES HRLGGEYAKLSSNPVKLSEITEQYLFLPPNRYIFHGAEVYSDSEDDV CC ATOM HRLGGEYAKLSSN------ITEQYLFLPPNRYIFHGAEVY------- CC ************* ********************* SQ SEQUENCE 397 AA; MW; CN; GSRDNLLFGD EIITNGFHSC ESDEEDRASH ASSSDWTPRP RIGPYTFVQQ HLMIGTDPRT ILKDLLPETI PPPELDDMTL WQIVINILSE PPKRKKRKDI NTIEDAVKLL QESKKIIVLT GAGVSVSSGI PDFRSRDGIY ARLAVDFPDL PDPQAMFDIE YFRKDPRPFF KFAKEIYPGQ FQPSLCHKFI ALSDKEGKLL RNYTQNIDTL EQVAGIQRII QCHGSFATAS CLICKYKVDC EAVRGDIFNQ VVPRCPRCPA DEPLAIMKPE IVFFGENLPE QFHRAMKYDK DEVDLLIVIG SSLKVRPVAL IPSSIPHEVP QILINREPLP HLHFDVELLG DCDVIINELC HRLGGEYAKL SSNPVKLSEI TEQYLFLPPN RYIFHGAEVY SDSEDDV // ID 5BTRC STANDARD; PRT; 397 AA. DT CONVERTED FROM PDB (SEQRES) 5BTR DE NAD-dependent protein deacetylase sirtuin-1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 3.200 CC R-Factor 0.209 FT #SUB 5 145 ASN C 78 218 MET A Protein B 2 FT #SUB 6 146 LEU C 45 185 TYR A Protein A 4 FT #SUB 6 146 LEU C 48 188 VAL A Protein S 2 FT #SUB 6 146 LEU C 52 192 LEU A Protein S 1 FT #SUB 6 146 LEU C 78 218 MET A Protein A 3 FT #SUB 6 146 LEU C 85 225 ILE A Protein S 1 FT #SUB 7 147 LEU C 45 185 TYR A Protein S 1 FT #SUB 8 148 PHE C 82 222 GLN A Protein S 7 FT #SUB 11 151 GLU C 45 185 TYR A Protein S 4 FT #SUB 35 175 ASP C 283 423 HIS A Protein S 1 FT #SUB 35 175 ASP C 287 427 LYS A Protein A 14 FT #SUB 35 175 ASP C 290 430 LYS A Protein B 1 FT #SUB 36 176 TRP C 282 422 PHE A Protein S 2 FT #SUB 36 176 TRP C 283 423 HIS A Protein S 8 FT #SUB 36 176 TRP C 286 426 MET A Protein S 6 FT #SUB 36 176 TRP C 290 430 LYS A Protein B 1 FT #SUB 36 176 TRP C 307 447 PRO A Protein S 1 FT #SUB 36 176 TRP C 314 454 SER A Protein S 3 FT #SUB 40 180 PRO C 45 185 TYR A Protein S 1 FT #SUB 42 182 ILE C 45 185 TYR A Protein S 3 FT #SUB 46 186 THR C 45 185 TYR A Protein S 1 FT #SUB 50 190 GLN C 49 189 GLN A Protein S 5 FT #SUB 53 193 MET C 49 189 GLN A Protein S 5 FT #SUB 53 193 MET C 52 192 LEU A Protein S 1 FT #SUB 45 185 TYR C 6 146 LEU B Protein A 2 FT #SUB 45 185 TYR C 7 147 LEU B Protein S 1 FT #SUB 45 185 TYR C 11 151 GLU B Protein S 6 FT #SUB 45 185 TYR C 40 180 PRO B Protein S 3 FT #SUB 45 185 TYR C 42 182 ILE B Protein S 3 FT #SUB 46 186 THR C 46 186 THR B Protein S 1 FT #SUB 48 188 VAL C 6 146 LEU B Protein S 3 FT #SUB 49 189 GLN C 6 146 LEU B Protein B 1 FT #SUB 49 189 GLN C 50 190 GLN B Protein S 4 FT #SUB 49 189 GLN C 53 193 MET B Protein S 4 FT #SUB 52 192 LEU C 6 146 LEU B Protein S 2 FT #SUB 78 218 MET C 3 143 ARG B Protein S 2 FT #SUB 78 218 MET C 4 144 ASP B Protein S 3 FT #SUB 78 218 MET C 5 145 ASN B Protein S 3 FT #SUB 78 218 MET C 6 146 LEU B Protein S 2 FT #SUB 81 221 TRP C 6 146 LEU B Protein S 1 FT #SUB 82 222 GLN C 8 148 PHE B Protein S 5 FT #SUB 85 225 ILE C 6 146 LEU B Protein S 1 FT #SUB 283 423 HIS C 34 174 SER B Protein A 3 FT #SUB 283 423 HIS C 36 176 TRP B Protein A 5 FT #SUB 284 424 ARG C 34 174 SER B Protein A 3 FT #SUB 286 426 MET C 36 176 TRP B Protein A 8 FT #SUB 287 427 LYS C 34 174 SER B Protein S 3 FT #SUB 287 427 LYS C 35 175 ASP B Protein S 4 FT #SUB 287 427 LYS C 36 176 TRP B Protein B 2 FT #SUB 290 430 LYS C 36 176 TRP B Protein S 3 FT #SUB 307 447 PRO C 36 176 TRP B Protein B 1 FT #SUB 314 454 SER C 36 176 TRP B Protein S 2 FT #SUB 314 454 SER C 37 177 THR B Protein S 2 FT #SUB 8 148 PHE C 1 0 ACE D Protein S 2 FT #SUB 8 148 PHE C 2 1 ARG D Protein S 3 FT #SUB 10 150 ASP C 2 1 ARG D Protein S 10 FT #SUB 11 151 GLU C 2 1 ARG D Protein S 1 FT #SUB 37 177 THR C 3 2 HIS D Protein S 2 FT #SUB 40 180 PRO C 2 1 ARG D Protein S 6 FT #SUB 45 185 TYR C 2 1 ARG F Protein S 2 FT #SUB 66 206 LEU C 5 4 FDL F Protein S 2 FT #SUB 69 209 THR C 5 4 FDL F Protein S 3 FT #SUB 86 226 ASN C 2 1 ARG F Protein S 6 FT #SUB 157 297 PHE C 5 4 FDL F Protein S 6 FT #SUB 223 363 HIS C 5 4 FDL F Protein S 10 FT #SUB 272 412 VAL C 5 4 FDL F Protein A 4 FT #SUB 273 413 PHE C 5 4 FDL F Protein B 3 FT #SUB 274 414 PHE C 5 4 FDL F Protein A 7 FT #SUB 275 415 GLY C 4 3 LYS F Protein B 2 FT #SUB 275 415 GLY C 5 4 FDL F Protein B 3 FT #SUB 276 416 GLU C 4 3 LYS F Protein B 2 FT #SUB 276 416 GLU C 5 4 FDL F Protein B 2 FT #SUB 277 417 ASN C 1 0 ACE F Protein S 1 FT #SUB 277 417 ASN C 4 3 LYS F Protein S 3 FT #SUB 278 418 LEU C 3 2 HIS F Protein S 1 FT #SUB 283 423 HIS C 3 2 HIS F Protein S 1 FT #SUB 304 444 LYS C 5 4 FDL F Protein B 3 FT #SUB 305 445 VAL C 5 4 FDL F Protein S 3 FT #SUB 306 446 ARG C 4 3 LYS F Protein B 1 FT #SUB 306 446 ARG C 5 4 FDL F Protein A 10 FT #SUB 307 447 PRO C 3 2 HIS F Protein S 4 FT #SUB 307 447 PRO C 4 3 LYS F Protein S 1 FT #HET 62 202 LEU C 12 101 STL F S 1 FT #HET 66 206 LEU C 12 101 STL F S 2 FT #HET 69 209 THR C 7 702 STL C S 2 FT #HET 71 211 PRO C 12 101 STL F A 3 FT #HET 72 212 PRO C 7 702 STL C S 4 FT #HET 72 212 PRO C 8 703 STL C S 1 FT #HET 74 214 GLU C 8 703 STL C S 2 FT #HET 75 215 LEU C 8 703 STL C S 3 FT #HET 79 219 THR C 8 703 STL C S 2 FT #HET 82 222 GLN C 8 703 STL C S 5 FT #HET 83 223 ILE C 8 703 STL C S 6 FT #HET 83 223 ILE C 12 101 STL F S 7 FT #HET 86 226 ASN C 8 703 STL C S 2 FT #HET 86 226 ASN C 12 101 STL F A 8 FT #HET 90 230 GLU C 12 101 STL F S 5 FT #HET 152 292 ASP C 7 702 STL C S 9 FT #HET 154 294 GLN C 7 702 STL C S 5 FT #HET 158 298 ASP C 7 702 STL C A 7 FT #HET 158 298 ASP C 8 703 STL C S 1 FT #HET 231 371 CYS C 6 701 ZN C S 1 FT #HET 233 373 ILE C 6 701 ZN C S 1 FT #HET 234 374 CYS C 6 701 ZN C A 2 FT #HET 255 395 CYS C 6 701 ZN C S 2 FT #HET 265 405 ALA C 6 701 ZN C S 1 FT #HET 274 414 PHE C 8 703 STL C S 4 FT #HET 275 415 GLY C 8 703 STL C B 6 FT #HET 304 444 LYS C 7 702 STL C A 3 FT #HET 305 445 VAL C 7 702 STL C S 2 FT #HET 306 446 ARG C 12 101 STL F A 7 FT #HET 307 447 PRO C 12 101 STL F A 8 FT #HET 310 450 LEU C 12 101 STL F S 3 FT DISORDER 1 3 FT DISORDER 16 34 FT DISORDER 122 139 FT DISORDER 256 264 FT DISORDER 362 375 FT DISORDER 386 397 CC SEQUENCE 322 AA (ATOM); CC DNLLFGDEII TNDWTPRPRI GPYTFVQQHL MIGTDPRTIL KDLLPETIPP PELDDMTLWQ CC IVINILSEPP KRKKRKDINT IEDAVKLLQE SKKIIVLTGY ARLAVDFPDL PDPQAMFDIE CC YFRKDPRPFF KFAKEIYPGQ FQPSLCHKFI ALSDKEGKLL RNYTQNIDTL EQVAGIQRII CC QCHGSFATAS CLICKYKVDC EAVRGDIFNQ VVPRCAIMKP EIVFFGENLP EQFHRAMKYD CC KDEVDLLIVI GSSLKVRPVA LIPSSIPHEV PQILINREPL PHLHFDVELL GDCDVIINEL CC CHRLGGEYAK LSFLPPNRYI FH CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTFVQQ CC ATOM ---DNLLFGDEIITN-------------------DWTPRPRIGPYTFVQQ CC ************ **************** CC SEQRES HLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI CC ATOM HLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI CC ************************************************** CC SEQRES NTIEDAVKLLQESKKIIVLTGAGVSVSSGIPDFRSRDGIYARLAVDFPDL CC ATOM NTIEDAVKLLQESKKIIVLTG------------------YARLAVDFPDL CC ********************* *********** CC SEQRES PDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLL CC ATOM PDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLL CC ************************************************** CC SEQRES RNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQ CC ATOM RNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQ CC ************************************************** CC SEQRES VVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIG CC ATOM VVPRC---------AIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIG CC ***** ************************************ CC SEQRES SSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELC CC ATOM SSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELC CC ************************************************** CC SEQRES HRLGGEYAKLSSNPVKLSEITEQYLFLPPNRYIFHGAEVYSDSEDDV CC ATOM HRLGGEYAKLS--------------FLPPNRYIFH------------ CC *********** ********** SQ SEQUENCE 397 AA; MW; CN; GSRDNLLFGD EIITNGFHSC ESDEEDRASH ASSSDWTPRP RIGPYTFVQQ HLMIGTDPRT ILKDLLPETI PPPELDDMTL WQIVINILSE PPKRKKRKDI NTIEDAVKLL QESKKIIVLT GAGVSVSSGI PDFRSRDGIY ARLAVDFPDL PDPQAMFDIE YFRKDPRPFF KFAKEIYPGQ FQPSLCHKFI ALSDKEGKLL RNYTQNIDTL EQVAGIQRII QCHGSFATAS CLICKYKVDC EAVRGDIFNQ VVPRCPRCPA DEPLAIMKPE IVFFGENLPE QFHRAMKYDK DEVDLLIVIG SSLKVRPVAL IPSSIPHEVP QILINREPLP HLHFDVELLG DCDVIINELC HRLGGEYAKL SSNPVKLSEI TEQYLFLPPN RYIFHGAEVY SDSEDDV // ID 5BTRD STANDARD; PRT; 5 AA. DT CONVERTED FROM PDB (SEQRES) 5BTR DE AMC-containing peptide OS syntetic CC EXPDTA X-RAY DIFFRACTION CC RESOLU 3.200 CC R-Factor 0.209 FT #SUB 1 0 ACE D 277 417 ASN A Protein A 2 FT #SUB 2 1 ARG D 45 185 TYR A Protein S 1 FT #SUB 2 1 ARG D 82 222 GLN A Protein A 2 FT #SUB 2 1 ARG D 86 226 ASN A Protein A 5 FT #SUB 3 2 HIS D 283 423 HIS A Protein S 1 FT #SUB 4 3 LYS D 275 415 GLY A Protein S 2 FT #SUB 4 3 LYS D 276 416 GLU A Protein A 3 FT #SUB 4 3 LYS D 277 417 ASN A Protein S 3 FT #SUB 4 3 LYS D 306 446 ARG A Protein B 1 FT #SUB 4 3 LYS D 307 447 PRO A Protein B 1 FT #SUB 5 4 FDL D 66 206 LEU A Protein S 1 FT #SUB 5 4 FDL D 69 209 THR A Protein S 3 FT #SUB 5 4 FDL D 134 274 ARG A Protein S 5 FT #SUB 5 4 FDL D 157 297 PHE A Protein S 2 FT #SUB 5 4 FDL D 223 363 HIS A Protein S 11 FT #SUB 5 4 FDL D 272 412 VAL A Protein S 7 FT #SUB 5 4 FDL D 273 413 PHE A Protein S 3 FT #SUB 5 4 FDL D 274 414 PHE A Protein A 6 FT #SUB 5 4 FDL D 275 415 GLY A Protein B 2 FT #SUB 5 4 FDL D 276 416 GLU A Protein A 3 FT #SUB 5 4 FDL D 278 418 LEU A Protein A 3 FT #SUB 5 4 FDL D 304 444 LYS A Protein S 1 FT #SUB 5 4 FDL D 305 445 VAL A Protein S 3 FT #SUB 5 4 FDL D 306 446 ARG A Protein A 7 FT #SUB 1 0 ACE D 8 148 PHE C Protein A 2 FT #SUB 2 1 ARG D 8 148 PHE C Protein A 3 FT #SUB 2 1 ARG D 10 150 ASP C Protein S 10 FT #SUB 2 1 ARG D 11 151 GLU C Protein S 1 FT #SUB 2 1 ARG D 40 180 PRO C Protein S 6 FT #SUB 3 2 HIS D 37 177 THR C Protein S 2 FT #HET 2 1 ARG D 9 101 STL D B 1 FT #HET 2 1 ARG D 10 102 STL D B 6 FT #HET 3 2 HIS D 9 101 STL D A 4 FT #HET 4 3 LYS D 9 101 STL D B 5 FT #HET 4 3 LYS D 10 102 STL D A 7 FT #HET 5 4 FDL D 2 702 STL A S 17 FT #HET 5 4 FDL D 9 101 STL D S 30 FT #HET 5 4 FDL D 10 102 STL D S 4 CC SEQUENCE 5 AA (ATOM); CC XRHKX CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES XRHKX CC ATOM XRHKX CC ***** SQ SEQUENCE 5 AA; MW; CN; XRHKX // ID 5BTRE STANDARD; PRT; 5 AA. DT CONVERTED FROM PDB (SEQRES) 5BTR DE AMC-containing peptide OS syntetic CC EXPDTA X-RAY DIFFRACTION CC RESOLU 3.200 CC R-Factor 0.209 FT #SUB 1 0 ACE E 8 148 PHE A Protein A 5 FT #SUB 2 1 ARG E 8 148 PHE A Protein A 2 FT #SUB 2 1 ARG E 10 150 ASP A Protein S 7 FT #SUB 2 1 ARG E 40 180 PRO A Protein S 6 FT #SUB 3 2 HIS E 37 177 THR A Protein S 2 FT #SUB 2 1 ARG E 86 226 ASN B Protein A 9 FT #SUB 3 2 HIS E 307 447 PRO B Protein B 2 FT #SUB 4 3 LYS E 275 415 GLY B Protein S 4 FT #SUB 4 3 LYS E 276 416 GLU B Protein A 3 FT #SUB 4 3 LYS E 277 417 ASN B Protein S 2 FT #SUB 4 3 LYS E 306 446 ARG B Protein B 1 FT #SUB 4 3 LYS E 307 447 PRO B Protein B 1 FT #SUB 5 4 FDL E 66 206 LEU B Protein S 1 FT #SUB 5 4 FDL E 72 212 PRO B Protein S 1 FT #SUB 5 4 FDL E 157 297 PHE B Protein S 2 FT #SUB 5 4 FDL E 223 363 HIS B Protein S 10 FT #SUB 5 4 FDL E 272 412 VAL B Protein S 7 FT #SUB 5 4 FDL E 273 413 PHE B Protein S 2 FT #SUB 5 4 FDL E 274 414 PHE B Protein A 7 FT #SUB 5 4 FDL E 275 415 GLY B Protein B 3 FT #SUB 5 4 FDL E 276 416 GLU B Protein A 4 FT #SUB 5 4 FDL E 278 418 LEU B Protein A 3 FT #SUB 5 4 FDL E 304 444 LYS B Protein S 1 FT #SUB 5 4 FDL E 305 445 VAL B Protein S 3 FT #SUB 5 4 FDL E 306 446 ARG B Protein A 7 FT #SUB 5 4 FDL E 307 447 PRO B Protein B 1 FT #HET 2 1 ARG E 5 703 STL B B 5 FT #HET 3 2 HIS E 11 101 STL E A 5 FT #HET 4 3 LYS E 5 703 STL B A 5 FT #HET 4 3 LYS E 11 101 STL E B 5 FT #HET 5 4 FDL E 4 702 STL B S 13 FT #HET 5 4 FDL E 5 703 STL B S 4 FT #HET 5 4 FDL E 11 101 STL E S 29 CC SEQUENCE 5 AA (ATOM); CC XRHKX CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES XRHKX CC ATOM XRHKX CC ***** SQ SEQUENCE 5 AA; MW; CN; XRHKX // ID 5BTRF STANDARD; PRT; 5 AA. DT CONVERTED FROM PDB (SEQRES) 5BTR DE AMC-containing peptide OS syntetic CC EXPDTA X-RAY DIFFRACTION CC RESOLU 3.200 CC R-Factor 0.209 FT #SUB 1 0 ACE F 8 148 PHE B Protein B 3 FT #SUB 2 1 ARG F 8 148 PHE B Protein A 2 FT #SUB 2 1 ARG F 10 150 ASP B Protein S 7 FT #SUB 2 1 ARG F 40 180 PRO B Protein S 2 FT #SUB 3 2 HIS F 36 176 TRP B Protein S 1 FT #SUB 3 2 HIS F 37 177 THR B Protein S 3 FT #SUB 1 0 ACE F 277 417 ASN C Protein S 1 FT #SUB 2 1 ARG F 45 185 TYR C Protein S 2 FT #SUB 2 1 ARG F 86 226 ASN C Protein A 6 FT #SUB 3 2 HIS F 278 418 LEU C Protein B 1 FT #SUB 3 2 HIS F 283 423 HIS C Protein S 1 FT #SUB 3 2 HIS F 307 447 PRO C Protein A 4 FT #SUB 4 3 LYS F 275 415 GLY C Protein S 2 FT #SUB 4 3 LYS F 276 416 GLU C Protein B 2 FT #SUB 4 3 LYS F 277 417 ASN C Protein S 3 FT #SUB 4 3 LYS F 306 446 ARG C Protein B 1 FT #SUB 4 3 LYS F 307 447 PRO C Protein B 1 FT #SUB 5 4 FDL F 66 206 LEU C Protein S 2 FT #SUB 5 4 FDL F 69 209 THR C Protein S 3 FT #SUB 5 4 FDL F 157 297 PHE C Protein S 6 FT #SUB 5 4 FDL F 223 363 HIS C Protein S 10 FT #SUB 5 4 FDL F 272 412 VAL C Protein S 4 FT #SUB 5 4 FDL F 273 413 PHE C Protein S 3 FT #SUB 5 4 FDL F 274 414 PHE C Protein A 7 FT #SUB 5 4 FDL F 275 415 GLY C Protein A 3 FT #SUB 5 4 FDL F 276 416 GLU C Protein A 2 FT #SUB 5 4 FDL F 304 444 LYS C Protein S 3 FT #SUB 5 4 FDL F 305 445 VAL C Protein S 3 FT #SUB 5 4 FDL F 306 446 ARG C Protein A 10 FT #HET 1 0 ACE F 8 703 STL C B 1 FT #HET 2 1 ARG F 8 703 STL C B 4 FT #HET 3 2 HIS F 12 101 STL F A 4 FT #HET 4 3 LYS F 8 703 STL C A 5 FT #HET 4 3 LYS F 12 101 STL F B 5 FT #HET 5 4 FDL F 7 702 STL C S 11 FT #HET 5 4 FDL F 8 703 STL C A 7 FT #HET 5 4 FDL F 12 101 STL F S 27 CC SEQUENCE 5 AA (ATOM); CC XRHKX CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES XRHKX CC ATOM XRHKX CC ***** SQ SEQUENCE 5 AA; MW; CN; XRHKX //