ID 4V0IA STANDARD; PRT; 940 AA. DT CONVERTED FROM PDB (SEQRES) 4V0I DE PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOF DE ORM OS MUS MUSCULUS CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.540 CC R-Factor 0.266 FT #SUB 83 187 ASN A 82 186 SER B Protein S 4 FT #SUB 83 187 ASN A 83 187 ASN B Protein S 5 FT #SUB 83 187 ASN A 84 188 ARG B Protein S 1 FT #SUB 438 542 PHE A 906 1010 GLU B Protein S 1 FT #SUB 440 544 GLU A 905 1009 GLU B Protein S 8 FT #SUB 471 575 PRO A 905 1009 GLU B Protein S 1 FT #SUB 699 803 GLN A 858 962 ARG B Protein B 1 FT #SUB 700 804 GLU A 700 804 GLU B Protein A 2 FT #SUB 700 804 GLU A 858 962 ARG B Protein A 2 FT #SUB 766 870 ARG A 81 185 VAL B Protein S 1 FT #SUB 858 962 ARG A 699 803 GLN B Protein S 1 FT #SUB 858 962 ARG A 700 804 GLU B Protein S 1 FT #SUB 865 969 ARG A 865 969 ARG B Protein S 10 FT #SUB 904 1008 GLU A 865 969 ARG B Protein S 1 FT #SUB 905 1009 GLU A 440 544 GLU B Protein S 3 FT #SUB 906 1010 GLU A 438 542 PHE B Protein S 1 FT #HET 647 751 PHE A 1 1500 J82 A B 2 FT #HET 648 752 MET A 1 1500 J82 A A 7 FT #HET 654 758 PRO A 1 1500 J82 A A 4 FT #HET 655 759 LEU A 1 1500 J82 A B 1 FT #HET 656 760 TRP A 1 1500 J82 A A 10 FT #HET 673 777 ILE A 1 1500 J82 A S 6 FT #HET 675 779 LYS A 1 1500 J82 A S 2 FT #HET 709 813 TYR A 1 1500 J82 A S 7 FT #HET 721 825 ILE A 1 1500 J82 A S 2 FT #HET 722 826 GLU A 1 1500 J82 A B 3 FT #HET 723 827 VAL A 1 1500 J82 A B 2 FT #HET 724 828 VAL A 1 1500 J82 A A 8 FT #HET 796 900 MET A 1 1500 J82 A S 2 FT #HET 804 908 PHE A 1 1500 J82 A S 1 FT #HET 806 910 ILE A 1 1500 J82 A S 11 FT #HET 807 911 ASP A 1 1500 J82 A A 4 FT DISORDER 1 5 FT DISORDER 70 80 FT DISORDER 124 130 FT DISORDER 188 216 FT DISORDER 225 238 FT DISORDER 254 273 FT DISORDER 293 310 FT DISORDER 341 347 FT DISORDER 376 377 FT DISORDER 391 420 FT DISORDER 736 742 FT DISORDER 814 826 FT DISORDER 923 940 CC SEQUENCE 759 AA (ATOM); CC KKLINSQISL LIGKGLHEFD SLRDPEVNDF RTKMRQFCEE AAAHRQQLGW VEWLQYSFPL CC QLEPVSNRAL LVNVKFEGSE ESFTFQVSTK DMPLALMACA LRKKATVQPE EYALQVNGRH CC EYLYGNYPLC HFQYICSCLH SGLTPHLTMV HSSSILAMRD EQSNQPFSIE LIVQAGLFHG CC NEMLCKTDIS VCDLPRMARL CFALYADCPI AWANLMLFDY KDQLKTGERC LYMWPSLLNP CC AGTVRGNPNT ESAAALVIYL PEVAPVYFPA LEKILELEHE KDLVWKMRHE VQEHFPEALA CC RLLLVTKWNK HEDVAQMLYL LCSWPELPVL SALELLDFSF PDCYVGSFAI KSLRKLTDDE CC LFQYLLQLVQ VLKYESYLDC ELTKFLLGRA LANRKIGHFL FWHLRSEMHV PSVALRFGLI CC MEAYCRGSTH HMKVLMKQGE ALSKLKALND FVKVSSQKTT KPQTKEMMHM CMRQETYMEA CC LSHLQSPLDP STLLEEVCVE QCTFMDSKMK PLWIMYSSEE AGSAGNVGII FKNGDDLRQD CC MLTLQMIQLM DVLWKQEGLD LRMTPYGCLP TGDRTGLIEV VLHSDTIANI QLTAAFNKDA CC LLNWLKSKNP GEALDRAIEE FTLSCAGYCV ATYVLGIGDR HSDNIMIRES GQLFHIDFGH CC FLGPFILTYD FVHVIQQGKT NNSEKFERFR GYCERAYTIL RRHGLLFLHL FALMRAAGLP CC ELSCSKDIQY LKDSLALGKT EEEALKHFRV KFNEALRES CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GGDRVKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHR CC ATOM -----KKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHR CC ********************************************* CC SEQRES QQLGWVEWLQYSFPLQLEPSARGWRAGLLRVSNRALLVNVKFEGSEESFT CC ATOM QQLGWVEWLQYSFPLQLEP-----------VSNRALLVNVKFEGSEESFT CC ******************* ******************** CC SEQRES FQVSTKDMPLALMACALRKKATVFRQPLVEQPEEYALQVNGRHEYLYGNY CC ATOM FQVSTKDMPLALMACALRKKATV-------QPEEYALQVNGRHEYLYGNY CC *********************** ******************** CC SEQRES PLCHFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPP CC ATOM PLCHFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSN------------- CC ************************************* CC SEQRES PIPAKKPSSVSLWSLEQPFSIELIEGRKVNADERMKLVVQAGLFHGNEML CC ATOM ----------------QPFSIELI--------------VQAGLFHGNEML CC ******** ************ CC SEQRES CKTVSSSEVNVCSEPVWKQRLEFDISVCDLPRMARLCFALYAVVEKAKKA CC ATOM CKT--------------------DISVCDLPRMARLCFALYA-------- CC *** ******************* CC SEQRES RSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLN CC ATOM ----------DCPIAWANLMLFDYKDQLKTGERCLYMWPS-------LLN CC ****************************** *** CC SEQRES PAGTVRGNPNTESAAALVIYLPEVAPHPVYFPALEKILELGRHGERGRIT CC ATOM PAGTVRGNPNTESAAALVIYLPEVA--PVYFPALEKILEL---------- CC ************************* ************* CC SEQRES EEEQLQLREILERRGSGELYEHEKDLVWKMRHEVQEHFPEALARLLLVTK CC ATOM --------------------EHEKDLVWKMRHEVQEHFPEALARLLLVTK CC ****************************** CC SEQRES WNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLT CC ATOM WNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLT CC ************************************************** CC SEQRES DDELFQYLLQLVQVLKYESYLDCELTKFLLGRALANRKIGHFLFWHLRSE CC ATOM DDELFQYLLQLVQVLKYESYLDCELTKFLLGRALANRKIGHFLFWHLRSE CC ************************************************** CC SEQRES MHVPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQ CC ATOM MHVPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQ CC ************************************************** CC SEQRES KTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTLLEEVCVEQCTFMDS CC ATOM KTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTLLEEVCVEQCTFMDS CC ************************************************** CC SEQRES KMKPLWIMYSSEEAGSAGNVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQE CC ATOM KMKPLWIMYSSEEAGSAGNVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQE CC ************************************************** CC SEQRES GLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDA CC ATOM GLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQL-------TAAFNKDA CC *********************************** ******** CC SEQRES LLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRES CC ATOM LLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRES CC ************************************************** CC SEQRES GQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFE CC ATOM GQLFHIDFGHFLG-------------PFILTYDFVHVIQQGKTNNSEKFE CC ************* ************************ CC SEQRES RFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLAL CC ATOM RFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLAL CC ************************************************** CC SEQRES GKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ CC ATOM GKTEEEALKHFRVKFNEALRES------------------ CC ********************** SQ SEQUENCE 940 AA; MW; CN; GGDRVKKLIN SQISLLIGKG LHEFDSLRDP EVNDFRTKMR QFCEEAAAHR QQLGWVEWLQ YSFPLQLEPS ARGWRAGLLR VSNRALLVNV KFEGSEESFT FQVSTKDMPL ALMACALRKK ATVFRQPLVE QPEEYALQVN GRHEYLYGNY PLCHFQYICS CLHSGLTPHL TMVHSSSILA MRDEQSNPAP QVQKPRAKPP PIPAKKPSSV SLWSLEQPFS IELIEGRKVN ADERMKLVVQ AGLFHGNEML CKTVSSSEVN VCSEPVWKQR LEFDISVCDL PRMARLCFAL YAVVEKAKKA RSTKKKSKKA DCPIAWANLM LFDYKDQLKT GERCLYMWPS VPDEKGELLN PAGTVRGNPN TESAAALVIY LPEVAPHPVY FPALEKILEL GRHGERGRIT EEEQLQLREI LERRGSGELY EHEKDLVWKM RHEVQEHFPE ALARLLLVTK WNKHEDVAQM LYLLCSWPEL PVLSALELLD FSFPDCYVGS FAIKSLRKLT DDELFQYLLQ LVQVLKYESY LDCELTKFLL GRALANRKIG HFLFWHLRSE MHVPSVALRF GLIMEAYCRG STHHMKVLMK QGEALSKLKA LNDFVKVSSQ KTTKPQTKEM MHMCMRQETY MEALSHLQSP LDPSTLLEEV CVEQCTFMDS KMKPLWIMYS SEEAGSAGNV GIIFKNGDDL RQDMLTLQMI QLMDVLWKQE GLDLRMTPYG CLPTGDRTGL IEVVLHSDTI ANIQLNKSNM AATAAFNKDA LLNWLKSKNP GEALDRAIEE FTLSCAGYCV ATYVLGIGDR HSDNIMIRES GQLFHIDFGH FLGNFKTKFG INRERVPFIL TYDFVHVIQQ GKTNNSEKFE RFRGYCERAY TILRRHGLLF LHLFALMRAA GLPELSCSKD IQYLKDSLAL GKTEEEALKH FRVKFNEALR ESWKTKVNWL AHNVSKDNRQ // ID 4V0IB STANDARD; PRT; 940 AA. DT CONVERTED FROM PDB (SEQRES) 4V0I DE PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOF DE ORM OS MUS MUSCULUS CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.540 CC R-Factor 0.266 FT #SUB 81 185 VAL B 766 870 ARG A Protein S 1 FT #SUB 82 186 SER B 83 187 ASN A Protein S 4 FT #SUB 83 187 ASN B 83 187 ASN A Protein A 5 FT #SUB 84 188 ARG B 83 187 ASN A Protein S 1 FT #SUB 438 542 PHE B 906 1010 GLU A Protein S 1 FT #SUB 440 544 GLU B 905 1009 GLU A Protein S 3 FT #SUB 699 803 GLN B 858 962 ARG A Protein B 1 FT #SUB 700 804 GLU B 700 804 GLU A Protein A 2 FT #SUB 700 804 GLU B 858 962 ARG A Protein B 1 FT #SUB 858 962 ARG B 699 803 GLN A Protein S 1 FT #SUB 858 962 ARG B 700 804 GLU A Protein S 2 FT #SUB 865 969 ARG B 865 969 ARG A Protein S 10 FT #SUB 865 969 ARG B 904 1008 GLU A Protein S 1 FT #SUB 905 1009 GLU B 440 544 GLU A Protein A 8 FT #SUB 905 1009 GLU B 471 575 PRO A Protein S 1 FT #SUB 906 1010 GLU B 438 542 PHE A Protein S 1 FT #HET 647 751 PHE B 2 1500 J82 B B 2 FT #HET 648 752 MET B 2 1500 J82 B A 7 FT #HET 654 758 PRO B 2 1500 J82 B A 5 FT #HET 656 760 TRP B 2 1500 J82 B A 10 FT #HET 673 777 ILE B 2 1500 J82 B S 7 FT #HET 675 779 LYS B 2 1500 J82 B S 4 FT #HET 709 813 TYR B 2 1500 J82 B S 7 FT #HET 721 825 ILE B 2 1500 J82 B S 3 FT #HET 722 826 GLU B 2 1500 J82 B B 3 FT #HET 723 827 VAL B 2 1500 J82 B B 2 FT #HET 724 828 VAL B 2 1500 J82 B A 8 FT #HET 796 900 MET B 2 1500 J82 B S 3 FT #HET 804 908 PHE B 2 1500 J82 B S 1 FT #HET 806 910 ILE B 2 1500 J82 B S 9 FT #HET 807 911 ASP B 2 1500 J82 B A 4 FT DISORDER 1 6 FT DISORDER 72 80 FT DISORDER 124 130 FT DISORDER 188 215 FT DISORDER 232 234 FT DISORDER 293 310 FT DISORDER 341 347 FT DISORDER 376 377 FT DISORDER 391 420 FT DISORDER 736 742 FT DISORDER 814 826 FT DISORDER 923 940 CC SEQUENCE 792 AA (ATOM); CC KLINSQISLL IGKGLHEFDS LRDPEVNDFR TKMRQFCEEA AAHRQQLGWV EWLQYSFPLQ CC LEPSAVSNRA LLVNVKFEGS EESFTFQVST KDMPLALMAC ALRKKATVQP EEYALQVNGR CC HEYLYGNYPL CHFQYICSCL HSGLTPHLTM VHSSSILAMR DEQSNEQPFS IELIEGRKVN CC AMKLVVQAGL FHGNEMLCKT VSSSEVNVCS EPVWKQRLEF DISVCDLPRM ARLCFALYAD CC CPIAWANLML FDYKDQLKTG ERCLYMWPSL LNPAGTVRGN PNTESAAALV IYLPEVAPVY CC FPALEKILEL EHEKDLVWKM RHEVQEHFPE ALARLLLVTK WNKHEDVAQM LYLLCSWPEL CC PVLSALELLD FSFPDCYVGS FAIKSLRKLT DDELFQYLLQ LVQVLKYESY LDCELTKFLL CC GRALANRKIG HFLFWHLRSE MHVPSVALRF GLIMEAYCRG STHHMKVLMK QGEALSKLKA CC LNDFVKVSSQ KTTKPQTKEM MHMCMRQETY MEALSHLQSP LDPSTLLEEV CVEQCTFMDS CC KMKPLWIMYS SEEAGSAGNV GIIFKNGDDL RQDMLTLQMI QLMDVLWKQE GLDLRMTPYG CC CLPTGDRTGL IEVVLHSDTI ANIQLTAAFN KDALLNWLKS KNPGEALDRA IEEFTLSCAG CC YCVATYVLGI GDRHSDNIMI RESGQLFHID FGHFLGPFIL TYDFVHVIQQ GKTNNSEKFE CC RFRGYCERAY TILRRHGLLF LHLFALMRAA GLPELSCSKD IQYLKDSLAL GKTEEEALKH CC FRVKFNEALR ES CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GGDRVKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHR CC ATOM ------KLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHR CC ******************************************** CC SEQRES QQLGWVEWLQYSFPLQLEPSARGWRAGLLRVSNRALLVNVKFEGSEESFT CC ATOM QQLGWVEWLQYSFPLQLEPSA---------VSNRALLVNVKFEGSEESFT CC ********************* ******************** CC SEQRES FQVSTKDMPLALMACALRKKATVFRQPLVEQPEEYALQVNGRHEYLYGNY CC ATOM FQVSTKDMPLALMACALRKKATV-------QPEEYALQVNGRHEYLYGNY CC *********************** ******************** CC SEQRES PLCHFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPP CC ATOM PLCHFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSN------------- CC ************************************* CC SEQRES PIPAKKPSSVSLWSLEQPFSIELIEGRKVNADERMKLVVQAGLFHGNEML CC ATOM ---------------EQPFSIELIEGRKVNA---MKLVVQAGLFHGNEML CC **************** **************** CC SEQRES CKTVSSSEVNVCSEPVWKQRLEFDISVCDLPRMARLCFALYAVVEKAKKA CC ATOM CKTVSSSEVNVCSEPVWKQRLEFDISVCDLPRMARLCFALYA-------- CC ****************************************** CC SEQRES RSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLN CC ATOM ----------DCPIAWANLMLFDYKDQLKTGERCLYMWPS-------LLN CC ****************************** *** CC SEQRES PAGTVRGNPNTESAAALVIYLPEVAPHPVYFPALEKILELGRHGERGRIT CC ATOM PAGTVRGNPNTESAAALVIYLPEVA--PVYFPALEKILEL---------- CC ************************* ************* CC SEQRES EEEQLQLREILERRGSGELYEHEKDLVWKMRHEVQEHFPEALARLLLVTK CC ATOM --------------------EHEKDLVWKMRHEVQEHFPEALARLLLVTK CC ****************************** CC SEQRES WNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLT CC ATOM WNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLT CC ************************************************** CC SEQRES DDELFQYLLQLVQVLKYESYLDCELTKFLLGRALANRKIGHFLFWHLRSE CC ATOM DDELFQYLLQLVQVLKYESYLDCELTKFLLGRALANRKIGHFLFWHLRSE CC ************************************************** CC SEQRES MHVPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQ CC ATOM MHVPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQ CC ************************************************** CC SEQRES KTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTLLEEVCVEQCTFMDS CC ATOM KTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTLLEEVCVEQCTFMDS CC ************************************************** CC SEQRES KMKPLWIMYSSEEAGSAGNVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQE CC ATOM KMKPLWIMYSSEEAGSAGNVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQE CC ************************************************** CC SEQRES GLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDA CC ATOM GLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQL-------TAAFNKDA CC *********************************** ******** CC SEQRES LLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRES CC ATOM LLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRES CC ************************************************** CC SEQRES GQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFE CC ATOM GQLFHIDFGHFLG-------------PFILTYDFVHVIQQGKTNNSEKFE CC ************* ************************ CC SEQRES RFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLAL CC ATOM RFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLAL CC ************************************************** CC SEQRES GKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ CC ATOM GKTEEEALKHFRVKFNEALRES------------------ CC ********************** SQ SEQUENCE 940 AA; MW; CN; GGDRVKKLIN SQISLLIGKG LHEFDSLRDP EVNDFRTKMR QFCEEAAAHR QQLGWVEWLQ YSFPLQLEPS ARGWRAGLLR VSNRALLVNV KFEGSEESFT FQVSTKDMPL ALMACALRKK ATVFRQPLVE QPEEYALQVN GRHEYLYGNY PLCHFQYICS CLHSGLTPHL TMVHSSSILA MRDEQSNPAP QVQKPRAKPP PIPAKKPSSV SLWSLEQPFS IELIEGRKVN ADERMKLVVQ AGLFHGNEML CKTVSSSEVN VCSEPVWKQR LEFDISVCDL PRMARLCFAL YAVVEKAKKA RSTKKKSKKA DCPIAWANLM LFDYKDQLKT GERCLYMWPS VPDEKGELLN PAGTVRGNPN TESAAALVIY LPEVAPHPVY FPALEKILEL GRHGERGRIT EEEQLQLREI LERRGSGELY EHEKDLVWKM RHEVQEHFPE ALARLLLVTK WNKHEDVAQM LYLLCSWPEL PVLSALELLD FSFPDCYVGS FAIKSLRKLT DDELFQYLLQ LVQVLKYESY LDCELTKFLL GRALANRKIG HFLFWHLRSE MHVPSVALRF GLIMEAYCRG STHHMKVLMK QGEALSKLKA LNDFVKVSSQ KTTKPQTKEM MHMCMRQETY MEALSHLQSP LDPSTLLEEV CVEQCTFMDS KMKPLWIMYS SEEAGSAGNV GIIFKNGDDL RQDMLTLQMI QLMDVLWKQE GLDLRMTPYG CLPTGDRTGL IEVVLHSDTI ANIQLNKSNM AATAAFNKDA LLNWLKSKNP GEALDRAIEE FTLSCAGYCV ATYVLGIGDR HSDNIMIRES GQLFHIDFGH FLGNFKTKFG INRERVPFIL TYDFVHVIQQ GKTNNSEKFE RFRGYCERAY TILRRHGLLF LHLFALMRAA GLPELSCSKD IQYLKDSLAL GKTEEEALKH FRVKFNEALR ESWKTKVNWL AHNVSKDNRQ //