ID 4NLDA STANDARD; PRT; 574 AA. DT CONVERTED FROM PDB (SEQRES) 4NLD DE RNA-directed RNA polymerase OS Hepatitis C virus CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.750 CC R-Factor 0.215 FT #HET 147 146 CYS A 7 607 BOG A B 1 FT #HET 148 147 VAL A 7 607 BOG A B 2 FT #HET 149 148 GLN A 7 607 BOG A A 12 FT #HET 151 150 GLU A 7 607 BOG A S 5 FT #HET 193 192 GLY A 2 602 2N5 A B 1 FT #HET 194 193 PHE A 2 602 2N5 A S 7 FT #HET 198 197 PRO A 2 602 2N5 A A 3 FT #HET 201 200 ARG A 2 602 2N5 A S 29 FT #HET 205 204 LEU A 2 602 2N5 A S 9 FT #HET 206 205 VAL A 8 608 BOG A S 1 FT #HET 210 209 LYS A 8 608 BOG A S 5 FT #HET 315 314 LEU A 2 602 2N5 A A 17 FT #HET 316 315 VAL A 2 602 2N5 A B 4 FT #HET 317 316 CYS A 2 602 2N5 A A 9 FT #HET 320 319 ASP A 2 602 2N5 A B 4 FT #HET 321 320 LEU A 2 602 2N5 A B 3 FT #HET 322 321 VAL A 2 602 2N5 A A 11 FT #HET 361 360 LEU A 2 602 2N5 A S 1 FT #HET 362 361 GLU A 8 608 BOG A A 3 FT #HET 364 363 ILE A 2 602 2N5 A A 6 FT #HET 366 365 SER A 2 602 2N5 A A 26 FT #HET 367 366 CYS A 2 602 2N5 A S 14 FT #HET 369 368 SER A 2 602 2N5 A A 17 FT #HET 370 369 ASN A 2 602 2N5 A B 2 FT #HET 371 370 VAL A 8 608 BOG A S 1 FT #HET 373 372 VAL A 8 608 BOG A S 1 FT #HET 375 374 HIS A 3 603 SO4 A S 6 FT #HET 381 380 ARG A 3 603 SO4 A S 10 FT #HET 381 380 ARG A 8 608 BOG A S 4 FT #HET 383 382 TYR A 8 608 BOG A S 6 FT #HET 385 384 LEU A 2 602 2N5 A S 6 FT #HET 393 392 LEU A 1 601 2N7 A A 19 FT #HET 394 393 ALA A 1 601 2N7 A A 8 FT #HET 395 394 ARG A 5 605 SO4 A S 9 FT #HET 396 395 ALA A 1 601 2N7 A A 13 FT #HET 397 396 ALA A 1 601 2N7 A A 25 FT #HET 398 397 TRP A 7 607 BOG A A 11 FT #HET 400 399 THR A 1 601 2N7 A A 13 FT #HET 401 400 ALA A 1 601 2N7 A A 3 FT #HET 401 400 ALA A 7 607 BOG A S 1 FT #HET 402 401 ARG A 7 607 BOG A S 8 FT #HET 415 414 MET A 2 602 2N5 A A 10 FT #HET 416 415 TYR A 2 602 2N5 A S 18 FT #HET 425 424 ILE A 1 601 2N7 A S 6 FT #HET 426 425 LEU A 1 601 2N7 A S 2 FT #HET 429 428 HIS A 1 601 2N7 A S 27 FT #HET 430 429 PHE A 1 601 2N7 A S 6 FT #HET 449 448 TYR A 2 602 2N5 A S 32 FT #HET 493 492 LEU A 1 601 2N7 A A 13 FT #HET 494 493 GLY A 1 601 2N7 A B 9 FT #HET 495 494 VAL A 1 601 2N7 A A 12 FT #HET 496 495 PRO A 1 601 2N7 A S 12 FT #HET 500 499 VAL A 4 604 SO4 A S 2 FT #HET 501 500 TRP A 1 601 2N7 A S 10 FT #HET 503 502 HIS A 4 604 SO4 A S 1 FT #HET 504 503 ARG A 1 601 2N7 A S 9 FT #HET 504 503 ARG A 4 604 SO4 A S 11 FT #HET 506 505 ARG A 6 606 SO4 A S 6 FT #HET 531 530 VAL A 6 606 SO4 A A 5 FT #HET 532 531 ARG A 6 606 SO4 A A 10 FT #HET 533 532 THR A 6 606 SO4 A A 9 FT DISORDER 1 54 FT DISORDER 270 274 FT DISORDER 560 574 CC SEQUENCE 500 AA (ATOM); CC FDRLQVLDDH YRDVLKEMKA KASTVKAKLL SVEEACKLTP PHSARSKFGY GAKDVRNLSS CC KAVNHIRSVW KDLLEDTETP IDTTIMAKNE VFCVQPEKGG RKPARLIVFP DLGVRVCEKM CC ALYDVVSTLP QAVMGSSYGF QYSPGQRVEF LVNAWKAKKC PMGFAYDTRC FDSTVTENDI CC RVEESIYQCC DLAPEARQAI RSLTERLYIG GPLTNCGYRR CRASGVLTTS CGNTLTCYLK CC AAAACRAAKL QDCTMLVCGD DLVVICESAG TQEDEASLRA FTEAMTRYSA PPGDPPKPEY CC DLELITSCSS NVSVAHDASG KRVYYLTRDP TTPLARAAWE TARHTPVNSW LGNIIMYAPT CC LWARMILMTH FFSILLAQEQ LEKALDCQIY GACYSIEPLD LPQIIQRLHG LSAFSLHSYS CC PGEINRVASC LRKLGVPPLR VWRHRARSVR ARLLSQGGRA ATCGKYLFNW AVRTKLKLTP CC IPAASQLDLS SWFVAGYSGG CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MSMSYTWTGALITPCAAEETKLPINALSNSLLRHHNLVYATTSRSASLRQ CC ATOM -------------------------------------------------- CC CC SEQRES KKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSARS CC ATOM ----FDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSARS CC ********************************************** CC SEQRES KFGYGAKDVRNLSSKAVNHIRSVWKDLLEDTETPIDTTIMAKNEVFCVQP CC ATOM KFGYGAKDVRNLSSKAVNHIRSVWKDLLEDTETPIDTTIMAKNEVFCVQP CC ************************************************** CC SEQRES EKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPGQ CC ATOM EKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPGQ CC ************************************************** CC SEQRES RVEFLVNAWKAKKCPMGFAYDTRCFDSTVTENDIRVEESIYQCCDLAPEA CC ATOM RVEFLVNAWKAKKCPMGFAYDTRCFDSTVTENDIRVEESIYQCCDLAPEA CC ************************************************** CC SEQRES RQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKA CC ATOM RQAIRSLTERLYIGGPLTN-----CGYRRCRASGVLTTSCGNTLTCYLKA CC ******************* ************************** CC SEQRES AAACRAAKLQDCTMLVCGDDLVVICESAGTQEDEASLRAFTEAMTRYSAP CC ATOM AAACRAAKLQDCTMLVCGDDLVVICESAGTQEDEASLRAFTEAMTRYSAP CC ************************************************** CC SEQRES PGDPPKPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWET CC ATOM PGDPPKPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWET CC ************************************************** CC SEQRES ARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYG CC ATOM ARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYG CC ************************************************** CC SEQRES ACYSIEPLDLPQIIQRLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRV CC ATOM ACYSIEPLDLPQIIQRLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRV CC ************************************************** CC SEQRES WRHRARSVRARLLSQGGRAATCGKYLFNWAVRTKLKLTPIPAASQLDLSS CC ATOM WRHRARSVRARLLSQGGRAATCGKYLFNWAVRTKLKLTPIPAASQLDLSS CC ************************************************** CC SEQRES WFVAGYSGGDIYHSLSRARPRWFM CC ATOM WFVAGYSGG--------------- CC ********* SQ SEQUENCE 574 AA; MW; CN; MSMSYTWTGA LITPCAAEET KLPINALSNS LLRHHNLVYA TTSRSASLRQ KKVTFDRLQV LDDHYRDVLK EMKAKASTVK AKLLSVEEAC KLTPPHSARS KFGYGAKDVR NLSSKAVNHI RSVWKDLLED TETPIDTTIM AKNEVFCVQP EKGGRKPARL IVFPDLGVRV CEKMALYDVV STLPQAVMGS SYGFQYSPGQ RVEFLVNAWK AKKCPMGFAY DTRCFDSTVT ENDIRVEESI YQCCDLAPEA RQAIRSLTER LYIGGPLTNS KGQNCGYRRC RASGVLTTSC GNTLTCYLKA AAACRAAKLQ DCTMLVCGDD LVVICESAGT QEDEASLRAF TEAMTRYSAP PGDPPKPEYD LELITSCSSN VSVAHDASGK RVYYLTRDPT TPLARAAWET ARHTPVNSWL GNIIMYAPTL WARMILMTHF FSILLAQEQL EKALDCQIYG ACYSIEPLDL PQIIQRLHGL SAFSLHSYSP GEINRVASCL RKLGVPPLRV WRHRARSVRA RLLSQGGRAA TCGKYLFNWA VRTKLKLTPI PAASQLDLSS WFVAGYSGGD IYHSLSRARP RWFM //