ID 4KY4A STANDARD; PRT; 610 AA. DT CONVERTED FROM PDB (SEQRES) 4KY4 DE Bifunctional dihydrofolate reductase-thymidylate synthase OS Toxoplasma gondii CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.790 CC R-Factor 0.222 FT #SUB 30 30 THR A 296 296 TRP B Protein S 2 FT #SUB 34 34 HIS A 293 293 VAL B Protein S 2 FT #SUB 34 34 HIS A 296 296 TRP B Protein A 9 FT #SUB 37 37 ARG A 296 296 TRP B Protein S 2 FT #SUB 37 37 ARG A 299 299 GLU B Protein S 5 FT #SUB 38 38 VAL A 293 293 VAL B Protein S 1 FT #SUB 168 168 HIS A 285 285 SER B Protein S 2 FT #SUB 170 170 TYR A 289 289 ALA B Protein S 6 FT #SUB 170 170 TYR A 293 293 VAL B Protein S 2 FT #SUB 230 230 ILE A 290 290 ILE B Protein S 1 FT #SUB 231 231 PHE A 290 290 ILE B Protein S 2 FT #SUB 231 231 PHE A 293 293 VAL B Protein S 3 FT #SUB 231 231 PHE A 297 297 MET B Protein S 1 FT #SUB 233 233 SER A 297 297 MET B Protein S 1 FT #SUB 236 236 PHE A 296 296 TRP B Protein S 1 FT #SUB 245 245 PHE A 296 296 TRP B Protein S 2 FT #SUB 245 245 PHE A 297 297 MET B Protein S 1 FT #SUB 249 249 GLU A 286 286 SER B Protein S 1 FT #SUB 286 286 SER A 249 249 GLU B Protein B 1 FT #SUB 289 289 ALA A 170 170 TYR B Protein A 6 FT #SUB 290 290 ILE A 230 230 ILE B Protein S 2 FT #SUB 290 290 ILE A 231 231 PHE B Protein S 2 FT #SUB 290 290 ILE A 319 319 PHE B Protein S 6 FT #SUB 293 293 VAL A 170 170 TYR B Protein S 1 FT #SUB 293 293 VAL A 231 231 PHE B Protein S 2 FT #SUB 294 294 LEU A 319 319 PHE B Protein S 2 FT #SUB 296 296 TRP A 30 30 THR B Protein S 2 FT #SUB 296 296 TRP A 34 34 HIS B Protein S 7 FT #SUB 296 296 TRP A 37 37 ARG B Protein S 3 FT #SUB 296 296 TRP A 245 245 PHE B Protein S 3 FT #SUB 297 297 MET A 233 233 SER B Protein S 1 FT #SUB 297 297 MET A 245 245 PHE B Protein S 1 FT #SUB 319 319 PHE A 290 290 ILE B Protein S 5 FT #SUB 319 319 PHE A 294 294 LEU B Protein S 3 FT #SUB 339 339 ARG A 499 499 ASP B Protein S 4 FT #SUB 341 341 MET A 467 467 THR B Protein S 1 FT #SUB 341 341 MET A 497 497 VAL B Protein S 1 FT #SUB 341 341 MET A 498 498 ASN B Protein S 1 FT #SUB 341 341 MET A 499 499 ASP B Protein S 1 FT #SUB 342 342 ASP A 467 467 THR B Protein B 3 FT #SUB 343 343 ASP A 469 469 ARG B Protein S 5 FT #SUB 349 349 VAL A 469 469 ARG B Protein S 1 FT #SUB 351 351 SER A 496 496 TYR B Protein A 6 FT #SUB 353 353 PHE A 358 358 ARG B Protein B 3 FT #SUB 353 353 PHE A 494 494 GLN B Protein S 5 FT #SUB 353 353 PHE A 495 495 PHE B Protein S 1 FT #SUB 353 353 PHE A 496 496 TYR B Protein S 16 FT #SUB 353 353 PHE A 504 504 SER B Protein S 1 FT #SUB 353 353 PHE A 506 506 ILE B Protein S 7 FT #SUB 353 353 PHE A 544 544 ILE B Protein B 1 FT #SUB 354 354 GLY A 358 358 ARG B Protein B 4 FT #SUB 354 354 GLY A 506 506 ILE B Protein B 2 FT #SUB 354 354 GLY A 546 546 PHE B Protein B 1 FT #SUB 355 355 CYS A 546 546 PHE B Protein B 1 FT #SUB 356 356 THR A 356 356 THR B Protein S 1 FT #SUB 358 358 ARG A 353 353 PHE B Protein S 1 FT #SUB 358 358 ARG A 354 354 GLY B Protein S 2 FT #SUB 415 415 ARG A 470 470 ARG B Protein S 1 FT #SUB 436 436 PHE A 477 477 ASN B Protein S 1 FT #SUB 436 436 PHE A 478 478 PRO B Protein S 3 FT #SUB 452 452 VAL A 478 478 PRO B Protein S 1 FT #SUB 454 454 GLN A 478 478 PRO B Protein S 2 FT #SUB 467 467 THR A 341 341 MET B Protein S 1 FT #SUB 467 467 THR A 342 342 ASP B Protein S 3 FT #SUB 469 469 ARG A 343 343 ASP B Protein S 6 FT #SUB 469 469 ARG A 349 349 VAL B Protein S 1 FT #SUB 469 469 ARG A 510 510 ARG B Protein A 5 FT #SUB 469 469 ARG A 511 511 SER B Protein S 3 FT #SUB 469 469 ARG A 549 549 ASN B Protein S 5 FT #SUB 469 469 ARG A 551 551 HIS B Protein S 5 FT #SUB 469 469 ARG A 553 553 TYR B Protein S 3 FT #SUB 470 470 ARG A 415 415 ARG B Protein S 1 FT #SUB 470 470 ARG A 486 486 LEU B Protein S 1 FT #SUB 470 470 ARG A 487 487 PRO B Protein S 6 FT #SUB 470 470 ARG A 510 510 ARG B Protein S 2 FT #SUB 472 472 LEU A 491 491 LEU B Protein S 1 FT #SUB 472 472 LEU A 510 510 ARG B Protein S 1 FT #SUB 474 474 THR A 478 478 PRO B Protein S 1 FT #SUB 476 476 TRP A 474 474 THR B Protein S 1 FT #SUB 477 477 ASN A 436 436 PHE B Protein S 1 FT #SUB 478 478 PRO A 436 436 PHE B Protein S 9 FT #SUB 478 478 PRO A 452 452 VAL B Protein B 1 FT #SUB 478 478 PRO A 454 454 GLN B Protein S 2 FT #SUB 479 479 ALA A 452 452 VAL B Protein B 1 FT #SUB 486 486 LEU A 470 470 ARG B Protein S 1 FT #SUB 487 487 PRO A 470 470 ARG B Protein S 5 FT #SUB 491 491 LEU A 472 472 LEU B Protein S 1 FT #SUB 491 491 LEU A 492 492 LEU B Protein S 1 FT #SUB 492 492 LEU A 491 491 LEU B Protein S 1 FT #SUB 492 492 LEU A 508 508 TYR B Protein S 1 FT #SUB 494 494 GLN A 353 353 PHE B Protein B 2 FT #SUB 494 494 GLN A 508 508 TYR B Protein S 5 FT #SUB 494 494 GLN A 510 510 ARG B Protein S 9 FT #SUB 494 494 GLN A 548 548 GLY B Protein S 1 FT #SUB 496 496 TYR A 351 351 SER B Protein S 6 FT #SUB 496 496 TYR A 353 353 PHE B Protein S 13 FT #SUB 496 496 TYR A 549 549 ASN B Protein S 2 FT #SUB 497 497 VAL A 341 341 MET B Protein B 1 FT #SUB 498 498 ASN A 341 341 MET B Protein B 4 FT #SUB 499 499 ASP A 339 339 ARG B Protein S 3 FT #SUB 499 499 ASP A 341 341 MET B Protein B 2 FT #SUB 504 504 SER A 353 353 PHE B Protein S 1 FT #SUB 506 506 ILE A 353 353 PHE B Protein A 7 FT #SUB 506 506 ILE A 354 354 GLY B Protein S 2 FT #SUB 506 506 ILE A 508 508 TYR B Protein S 2 FT #SUB 508 508 TYR A 492 492 LEU B Protein S 3 FT #SUB 508 508 TYR A 494 494 GLN B Protein S 5 FT #SUB 508 508 TYR A 506 506 ILE B Protein S 2 FT #SUB 508 508 TYR A 546 546 PHE B Protein S 2 FT #SUB 510 510 ARG A 469 469 ARG B Protein S 4 FT #SUB 510 510 ARG A 470 470 ARG B Protein S 3 FT #SUB 510 510 ARG A 472 472 LEU B Protein S 1 FT #SUB 510 510 ARG A 494 494 GLN B Protein A 8 FT #SUB 511 511 SER A 469 469 ARG B Protein S 3 FT #SUB 544 544 ILE A 353 353 PHE B Protein S 3 FT #SUB 544 544 ILE A 354 354 GLY B Protein S 1 FT #SUB 546 546 PHE A 355 355 CYS B Protein S 1 FT #SUB 546 546 PHE A 356 356 THR B Protein S 1 FT #SUB 546 546 PHE A 508 508 TYR B Protein S 2 FT #SUB 546 546 PHE A 546 546 PHE B Protein S 3 FT #SUB 547 547 MET A 546 546 PHE B Protein B 1 FT #SUB 548 548 GLY A 494 494 GLN B Protein B 1 FT #SUB 548 548 GLY A 506 506 ILE B Protein B 1 FT #SUB 549 549 ASN A 469 469 ARG B Protein S 5 FT #SUB 549 549 ASN A 494 494 GLN B Protein B 1 FT #SUB 549 549 ASN A 496 496 TYR B Protein S 2 FT #SUB 551 551 HIS A 469 469 ARG B Protein S 9 FT #SUB 553 553 TYR A 469 469 ARG B Protein S 3 FT #HET 8 8 VAL A 2 702 04J A A 5 FT #HET 9 9 VAL A 2 702 04J A B 7 FT #HET 9 9 VAL A 3 703 NDP A A 4 FT #HET 10 10 ALA A 2 702 04J A A 5 FT #HET 10 10 ALA A 3 703 NDP A B 8 FT #HET 17 17 ILE A 3 703 NDP A A 6 FT #HET 18 18 GLY A 3 703 NDP A B 2 FT #HET 19 19 ILE A 3 703 NDP A B 1 FT #HET 21 21 ASN A 3 703 NDP A A 7 FT #HET 22 22 GLY A 3 703 NDP A B 11 FT #HET 23 23 LEU A 3 703 NDP A A 2 FT #HET 25 25 TRP A 2 702 04J A S 1 FT #HET 25 25 TRP A 3 703 NDP A S 1 FT #HET 31 31 ASP A 2 702 04J A S 13 FT #HET 32 32 PHE A 2 702 04J A A 14 FT #HET 35 35 PHE A 2 702 04J A S 8 FT #HET 36 36 SER A 2 702 04J A S 3 FT #HET 80 80 GLY A 3 703 NDP A B 7 FT #HET 81 81 ARG A 3 703 NDP A A 16 FT #HET 82 82 LYS A 3 703 NDP A A 10 FT #HET 83 83 THR A 3 703 NDP A A 10 FT #HET 86 86 SER A 3 703 NDP A S 4 FT #HET 87 87 MET A 2 702 04J A S 1 FT #HET 91 91 PHE A 2 702 04J A S 7 FT #HET 94 94 LEU A 2 702 04J A S 2 FT #HET 97 97 ARG A 2 702 04J A S 3 FT #HET 102 102 VAL A 3 703 NDP A B 4 FT #HET 103 103 SER A 3 703 NDP A A 6 FT #HET 104 104 SER A 3 703 NDP A A 6 FT #HET 128 128 ALA A 3 703 NDP A B 1 FT #HET 151 151 VAL A 3 703 NDP A B 2 FT #HET 153 153 GLY A 3 703 NDP A B 11 FT #HET 154 154 ALA A 3 703 NDP A A 11 FT #HET 155 155 GLY A 3 703 NDP A B 3 FT #HET 156 156 LEU A 3 703 NDP A B 2 FT #HET 157 157 TYR A 3 703 NDP A S 2 FT #HET 172 172 THR A 2 702 04J A S 2 FT #HET 182 182 VAL A 3 703 NDP A S 2 FT #HET 381 381 GLU A 4 704 1UE A S 2 FT #HET 402 402 ILE A 4 704 1UE A A 6 FT #HET 403 403 TRP A 4 704 1UE A S 5 FT #HET 406 406 ASN A 4 704 1UE A S 1 FT #HET 429 429 TYR A 1 701 UMP A S 1 FT #HET 469 469 ARG A 5 701 UMP B S 11 FT #HET 470 470 ARG A 5 701 UMP B S 4 FT #HET 489 489 CYS A 1 701 UMP A S 12 FT #HET 490 490 HIS A 1 701 UMP A S 2 FT #HET 509 509 GLN A 1 701 UMP A S 3 FT #HET 510 510 ARG A 1 701 UMP A S 9 FT #HET 511 511 SER A 1 701 UMP A A 11 FT #HET 512 512 CYS A 1 701 UMP A B 2 FT #HET 513 513 ASP A 1 701 UMP A A 4 FT #HET 513 513 ASP A 4 704 1UE A S 4 FT #HET 516 516 LEU A 4 704 1UE A A 15 FT #HET 517 517 GLY A 1 701 UMP A B 1 FT #HET 517 517 GLY A 4 704 1UE A B 7 FT #HET 521 521 ASN A 1 701 UMP A S 8 FT #HET 551 551 HIS A 1 701 UMP A S 6 FT #HET 553 553 TYR A 1 701 UMP A S 4 FT #HET 608 608 MET A 4 704 1UE A S 6 FT #HET 609 609 ALA A 4 704 1UE A B 2 FT DISORDER 1 2 FT DISORDER 42 73 FT DISORDER 108 125 FT DISORDER 152 152 FT DISORDER 197 223 FT DISORDER 252 284 FT DISORDER 300 307 CC SEQUENCE 489 AA (ATOM); CC KPVCLVVAMT PKRGIGINNG LPWPHLTTDF KHFSRVTKTF NAVVMGRKTW ESMPRKFRPL CC VDRLNIVVSS SLKVCASLPA ALSLLEEEYK DSVDQIFVVG AGLYEAALSL GVASHLYITR CC VAREFPCDVF FPAFPGDDIL SNKEATYRPI FISKTFSDNG VPYDFVVLEK RSSAAAIAPV CC LAWMDEKELI RAVPHVHFRG HEEFQYLDLI ADIINNGRTM DDRTGVGVIS KFGCTMRYSL CC DQAFPLLTTK RVFWKGVLEE LLWFIRGDTN ANHLSEKGVK IWDKNVTREF LDSRNLPHRE CC VGDIGPGYGF QWRHFGAAYK DMHTDYTGQG VDQLKNVIQM LRTNPTDRRM LMTAWNPAAL CC DEMALPPCHL LCQFYVNDQK ELSCIMYQRS CDVGLGVPFN IASYSLLTLM VAHVCNLKPK CC EFIHFMGNTH VYTNHVEALK EQLRREPRPF PIVNILNKER IKEIDDFTAE DFEVVGYVPH CC GRIQMEMAV CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLN CC ATOM --KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKT--------- CC *************************************** CC SEQRES GWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNI CC ATOM -----------------------FNAVVMGRKTWESMPRKFRPLVDRLNI CC *************************** CC SEQRES VVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFV CC ATOM VVSSSLK------------------VCASLPAALSLLEEEYKDSVDQIFV CC ******* ************************* CC SEQRES VGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAA CC ATOM V-GAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNK---- CC * ******************************************** CC SEQRES QAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEK CC ATOM -----------------------EATYRPIFISKTFSDNGVPYDFVVLEK CC *************************** CC SEQRES RRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEE CC ATOM R---------------------------------SSAAAIAPVLAWMDE- CC * *************** CC SEQRES DRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVI CC ATOM -------KELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVI CC ******************************************* CC SEQRES SKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGV CC ATOM SKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGV CC ************************************************** CC SEQRES KIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQ CC ATOM KIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQ CC ************************************************** CC SEQRES GVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQ CC ATOM GVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQ CC ************************************************** CC SEQRES KELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNT CC ATOM KELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNT CC ************************************************** CC SEQRES HVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP CC ATOM HVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP CC ************************************************** CC SEQRES HGRIQMEMAV CC ATOM HGRIQMEMAV CC ********** SQ SEQUENCE 610 AA; MW; CN; MQKPVCLVVA MTPKRGIGIN NGLPWPHLTT DFKHFSRVTK TTPEEASRLN GWLPRKFAKT GDSGLPSPSV GKRFNAVVMG RKTWESMPRK FRPLVDRLNI VVSSSLKEED IAAEKPQAEG QQRVRVCASL PAALSLLEEE YKDSVDQIFV VGGAGLYEAA LSLGVASHLY ITRVAREFPC DVFFPAFPGD DILSNKSTAA QAAAPAESVF VPFCPELGRE KDNEATYRPI FISKTFSDNG VPYDFVVLEK RRKTDDAATA EPSNAMSSLT STRETTPVHG LQAPSSAAAI APVLAWMDEE DRKKREQKEL IRAVPHVHFR GHEEFQYLDL IADIINNGRT MDDRTGVGVI SKFGCTMRYS LDQAFPLLTT KRVFWKGVLE ELLWFIRGDT NANHLSEKGV KIWDKNVTRE FLDSRNLPHR EVGDIGPGYG FQWRHFGAAY KDMHTDYTGQ GVDQLKNVIQ MLRTNPTDRR MLMTAWNPAA LDEMALPPCH LLCQFYVNDQ KELSCIMYQR SCDVGLGVPF NIASYSLLTL MVAHVCNLKP KEFIHFMGNT HVYTNHVEAL KEQLRREPRP FPIVNILNKE RIKEIDDFTA EDFEVVGYVP HGRIQMEMAV // ID 4KY4B STANDARD; PRT; 610 AA. DT CONVERTED FROM PDB (SEQRES) 4KY4 DE Bifunctional dihydrofolate reductase-thymidylate synthase OS Toxoplasma gondii CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.790 CC R-Factor 0.222 FT #SUB 30 30 THR B 296 296 TRP A Protein S 2 FT #SUB 34 34 HIS B 296 296 TRP A Protein A 7 FT #SUB 37 37 ARG B 296 296 TRP A Protein S 3 FT #SUB 170 170 TYR B 289 289 ALA A Protein S 6 FT #SUB 170 170 TYR B 293 293 VAL A Protein S 1 FT #SUB 230 230 ILE B 290 290 ILE A Protein S 2 FT #SUB 231 231 PHE B 290 290 ILE A Protein S 2 FT #SUB 231 231 PHE B 293 293 VAL A Protein S 2 FT #SUB 233 233 SER B 297 297 MET A Protein S 1 FT #SUB 245 245 PHE B 296 296 TRP A Protein S 3 FT #SUB 245 245 PHE B 297 297 MET A Protein S 1 FT #SUB 249 249 GLU B 286 286 SER A Protein S 1 FT #SUB 285 285 SER B 168 168 HIS A Protein B 2 FT #SUB 286 286 SER B 249 249 GLU A Protein S 1 FT #SUB 289 289 ALA B 170 170 TYR A Protein A 6 FT #SUB 290 290 ILE B 230 230 ILE A Protein S 1 FT #SUB 290 290 ILE B 231 231 PHE A Protein S 2 FT #SUB 290 290 ILE B 319 319 PHE A Protein S 5 FT #SUB 293 293 VAL B 34 34 HIS A Protein S 2 FT #SUB 293 293 VAL B 38 38 VAL A Protein S 1 FT #SUB 293 293 VAL B 170 170 TYR A Protein S 2 FT #SUB 293 293 VAL B 231 231 PHE A Protein S 3 FT #SUB 294 294 LEU B 319 319 PHE A Protein S 3 FT #SUB 296 296 TRP B 30 30 THR A Protein S 2 FT #SUB 296 296 TRP B 34 34 HIS A Protein S 9 FT #SUB 296 296 TRP B 37 37 ARG A Protein S 2 FT #SUB 296 296 TRP B 236 236 PHE A Protein S 1 FT #SUB 296 296 TRP B 245 245 PHE A Protein S 2 FT #SUB 297 297 MET B 231 231 PHE A Protein S 1 FT #SUB 297 297 MET B 233 233 SER A Protein S 1 FT #SUB 297 297 MET B 245 245 PHE A Protein S 1 FT #SUB 299 299 GLU B 37 37 ARG A Protein S 5 FT #SUB 319 319 PHE B 290 290 ILE A Protein S 6 FT #SUB 319 319 PHE B 294 294 LEU A Protein S 2 FT #SUB 339 339 ARG B 499 499 ASP A Protein S 3 FT #SUB 341 341 MET B 467 467 THR A Protein S 1 FT #SUB 341 341 MET B 497 497 VAL A Protein S 1 FT #SUB 341 341 MET B 498 498 ASN A Protein S 4 FT #SUB 341 341 MET B 499 499 ASP A Protein S 2 FT #SUB 342 342 ASP B 467 467 THR A Protein B 3 FT #SUB 343 343 ASP B 469 469 ARG A Protein S 6 FT #SUB 349 349 VAL B 469 469 ARG A Protein S 1 FT #SUB 351 351 SER B 496 496 TYR A Protein A 6 FT #SUB 353 353 PHE B 358 358 ARG A Protein B 1 FT #SUB 353 353 PHE B 494 494 GLN A Protein S 2 FT #SUB 353 353 PHE B 496 496 TYR A Protein S 13 FT #SUB 353 353 PHE B 504 504 SER A Protein S 1 FT #SUB 353 353 PHE B 506 506 ILE A Protein S 7 FT #SUB 353 353 PHE B 544 544 ILE A Protein A 3 FT #SUB 354 354 GLY B 358 358 ARG A Protein B 2 FT #SUB 354 354 GLY B 506 506 ILE A Protein B 2 FT #SUB 354 354 GLY B 544 544 ILE A Protein B 1 FT #SUB 355 355 CYS B 546 546 PHE A Protein B 1 FT #SUB 356 356 THR B 356 356 THR A Protein S 1 FT #SUB 356 356 THR B 546 546 PHE A Protein S 1 FT #SUB 358 358 ARG B 353 353 PHE A Protein S 3 FT #SUB 358 358 ARG B 354 354 GLY A Protein S 4 FT #SUB 415 415 ARG B 470 470 ARG A Protein S 1 FT #SUB 436 436 PHE B 477 477 ASN A Protein S 1 FT #SUB 436 436 PHE B 478 478 PRO A Protein S 9 FT #SUB 452 452 VAL B 478 478 PRO A Protein S 1 FT #SUB 452 452 VAL B 479 479 ALA A Protein S 1 FT #SUB 454 454 GLN B 478 478 PRO A Protein S 2 FT #SUB 467 467 THR B 341 341 MET A Protein S 1 FT #SUB 467 467 THR B 342 342 ASP A Protein S 3 FT #SUB 469 469 ARG B 343 343 ASP A Protein S 5 FT #SUB 469 469 ARG B 349 349 VAL A Protein S 1 FT #SUB 469 469 ARG B 510 510 ARG A Protein A 4 FT #SUB 469 469 ARG B 511 511 SER A Protein S 3 FT #SUB 469 469 ARG B 549 549 ASN A Protein S 5 FT #SUB 469 469 ARG B 551 551 HIS A Protein S 9 FT #SUB 469 469 ARG B 553 553 TYR A Protein S 3 FT #SUB 470 470 ARG B 415 415 ARG A Protein S 1 FT #SUB 470 470 ARG B 486 486 LEU A Protein S 1 FT #SUB 470 470 ARG B 487 487 PRO A Protein S 5 FT #SUB 470 470 ARG B 510 510 ARG A Protein S 3 FT #SUB 472 472 LEU B 491 491 LEU A Protein S 1 FT #SUB 472 472 LEU B 510 510 ARG A Protein S 1 FT #SUB 474 474 THR B 476 476 TRP A Protein S 1 FT #SUB 477 477 ASN B 436 436 PHE A Protein S 1 FT #SUB 478 478 PRO B 436 436 PHE A Protein S 3 FT #SUB 478 478 PRO B 452 452 VAL A Protein B 1 FT #SUB 478 478 PRO B 454 454 GLN A Protein S 2 FT #SUB 478 478 PRO B 474 474 THR A Protein S 1 FT #SUB 486 486 LEU B 470 470 ARG A Protein S 1 FT #SUB 487 487 PRO B 470 470 ARG A Protein S 6 FT #SUB 491 491 LEU B 472 472 LEU A Protein S 1 FT #SUB 491 491 LEU B 492 492 LEU A Protein S 1 FT #SUB 492 492 LEU B 491 491 LEU A Protein S 1 FT #SUB 492 492 LEU B 508 508 TYR A Protein S 3 FT #SUB 494 494 GLN B 353 353 PHE A Protein A 5 FT #SUB 494 494 GLN B 508 508 TYR A Protein S 5 FT #SUB 494 494 GLN B 510 510 ARG A Protein S 8 FT #SUB 494 494 GLN B 548 548 GLY A Protein S 1 FT #SUB 494 494 GLN B 549 549 ASN A Protein S 1 FT #SUB 495 495 PHE B 353 353 PHE A Protein B 1 FT #SUB 496 496 TYR B 351 351 SER A Protein S 6 FT #SUB 496 496 TYR B 353 353 PHE A Protein S 16 FT #SUB 496 496 TYR B 549 549 ASN A Protein S 2 FT #SUB 497 497 VAL B 341 341 MET A Protein B 1 FT #SUB 498 498 ASN B 341 341 MET A Protein B 1 FT #SUB 499 499 ASP B 339 339 ARG A Protein S 4 FT #SUB 499 499 ASP B 341 341 MET A Protein B 1 FT #SUB 504 504 SER B 353 353 PHE A Protein S 1 FT #SUB 506 506 ILE B 353 353 PHE A Protein A 7 FT #SUB 506 506 ILE B 354 354 GLY A Protein S 2 FT #SUB 506 506 ILE B 508 508 TYR A Protein S 2 FT #SUB 506 506 ILE B 548 548 GLY A Protein S 1 FT #SUB 508 508 TYR B 492 492 LEU A Protein S 1 FT #SUB 508 508 TYR B 494 494 GLN A Protein S 5 FT #SUB 508 508 TYR B 506 506 ILE A Protein S 2 FT #SUB 508 508 TYR B 546 546 PHE A Protein S 2 FT #SUB 510 510 ARG B 469 469 ARG A Protein S 5 FT #SUB 510 510 ARG B 470 470 ARG A Protein S 2 FT #SUB 510 510 ARG B 472 472 LEU A Protein S 1 FT #SUB 510 510 ARG B 494 494 GLN A Protein A 9 FT #SUB 511 511 SER B 469 469 ARG A Protein S 3 FT #SUB 544 544 ILE B 353 353 PHE A Protein S 1 FT #SUB 546 546 PHE B 354 354 GLY A Protein S 1 FT #SUB 546 546 PHE B 355 355 CYS A Protein S 1 FT #SUB 546 546 PHE B 508 508 TYR A Protein S 2 FT #SUB 546 546 PHE B 546 546 PHE A Protein S 3 FT #SUB 546 546 PHE B 547 547 MET A Protein S 1 FT #SUB 548 548 GLY B 494 494 GLN A Protein B 1 FT #SUB 549 549 ASN B 469 469 ARG A Protein S 5 FT #SUB 549 549 ASN B 496 496 TYR A Protein S 2 FT #SUB 551 551 HIS B 469 469 ARG A Protein S 5 FT #SUB 553 553 TYR B 469 469 ARG A Protein S 3 FT #SUB 14 14 LYS B 591 591 GLU C Protein S 4 FT #SUB 15 15 ARG B 397 397 GLU C Protein S 1 FT #SUB 19 19 ILE B 581 581 ARG C Protein S 4 FT #SUB 20 20 ASN B 581 581 ARG C Protein S 2 FT #SUB 177 177 GLU B 591 591 GLU C Protein S 2 FT #SUB 178 178 PHE B 591 591 GLU C Protein B 3 FT #SUB 179 179 PRO B 578 578 ASN C Protein S 1 FT #SUB 179 179 PRO B 581 581 ARG C Protein S 1 FT #SUB 179 179 PRO B 589 589 THR C Protein A 2 FT #SUB 179 179 PRO B 591 591 GLU C Protein A 4 FT #SUB 179 179 PRO B 592 592 ASP C Protein S 2 FT #SUB 180 180 CYS B 589 589 THR C Protein B 1 FT #SUB 196 196 LYS B 397 397 GLU C Protein S 2 FT #SUB 397 397 GLU B 15 15 ARG C Protein S 1 FT #SUB 578 578 ASN B 179 179 PRO C Protein S 1 FT #SUB 581 581 ARG B 19 19 ILE C Protein S 3 FT #SUB 581 581 ARG B 20 20 ASN C Protein S 2 FT #SUB 581 581 ARG B 179 179 PRO C Protein S 1 FT #SUB 589 589 THR B 179 179 PRO C Protein S 2 FT #SUB 589 589 THR B 180 180 CYS C Protein S 1 FT #SUB 591 591 GLU B 14 14 LYS C Protein S 5 FT #SUB 591 591 GLU B 178 178 PHE C Protein S 2 FT #SUB 591 591 GLU B 179 179 PRO C Protein S 6 FT #SUB 592 592 ASP B 179 179 PRO C Protein S 1 FT #HET 8 8 VAL B 6 702 04J B A 5 FT #HET 9 9 VAL B 6 702 04J B B 8 FT #HET 9 9 VAL B 7 703 NDP B A 4 FT #HET 10 10 ALA B 6 702 04J B A 4 FT #HET 10 10 ALA B 7 703 NDP B A 8 FT #HET 17 17 ILE B 7 703 NDP B A 10 FT #HET 18 18 GLY B 7 703 NDP B B 3 FT #HET 19 19 ILE B 7 703 NDP B B 1 FT #HET 21 21 ASN B 7 703 NDP B A 6 FT #HET 22 22 GLY B 7 703 NDP B B 7 FT #HET 23 23 LEU B 7 703 NDP B S 3 FT #HET 25 25 TRP B 7 703 NDP B S 2 FT #HET 31 31 ASP B 6 702 04J B S 7 FT #HET 32 32 PHE B 6 702 04J B A 10 FT #HET 35 35 PHE B 6 702 04J B S 12 FT #HET 36 36 SER B 6 702 04J B A 4 FT #HET 80 80 GLY B 7 703 NDP B B 7 FT #HET 81 81 ARG B 7 703 NDP B A 15 FT #HET 82 82 LYS B 7 703 NDP B A 12 FT #HET 83 83 THR B 7 703 NDP B A 11 FT #HET 86 86 SER B 7 703 NDP B S 3 FT #HET 87 87 MET B 6 702 04J B S 1 FT #HET 91 91 PHE B 6 702 04J B S 5 FT #HET 94 94 LEU B 6 702 04J B S 1 FT #HET 97 97 ARG B 6 702 04J B S 5 FT #HET 102 102 VAL B 7 703 NDP B A 5 FT #HET 103 103 SER B 7 703 NDP B A 8 FT #HET 104 104 SER B 7 703 NDP B A 5 FT #HET 105 105 SER B 7 703 NDP B A 2 FT #HET 128 128 ALA B 7 703 NDP B B 1 FT #HET 151 151 VAL B 6 702 04J B S 1 FT #HET 153 153 GLY B 7 703 NDP B B 5 FT #HET 154 154 ALA B 7 703 NDP B A 8 FT #HET 155 155 GLY B 7 703 NDP B B 3 FT #HET 157 157 TYR B 7 703 NDP B S 2 FT #HET 172 172 THR B 6 702 04J B S 1 FT #HET 182 182 VAL B 7 703 NDP B S 3 FT #HET 381 381 GLU B 8 704 1UE B S 1 FT #HET 402 402 ILE B 8 704 1UE B B 2 FT #HET 403 403 TRP B 8 704 1UE B S 5 FT #HET 406 406 ASN B 8 704 1UE B S 3 FT #HET 429 429 TYR B 5 701 UMP B S 1 FT #HET 469 469 ARG B 1 701 UMP A S 10 FT #HET 470 470 ARG B 1 701 UMP A S 6 FT #HET 489 489 CYS B 5 701 UMP B S 13 FT #HET 490 490 HIS B 5 701 UMP B S 2 FT #HET 509 509 GLN B 5 701 UMP B S 3 FT #HET 510 510 ARG B 5 701 UMP B S 6 FT #HET 511 511 SER B 5 701 UMP B A 11 FT #HET 512 512 CYS B 5 701 UMP B B 2 FT #HET 513 513 ASP B 5 701 UMP B A 4 FT #HET 513 513 ASP B 8 704 1UE B S 4 FT #HET 516 516 LEU B 8 704 1UE B S 7 FT #HET 517 517 GLY B 8 704 1UE B B 2 FT #HET 520 520 PHE B 8 704 1UE B S 1 FT #HET 521 521 ASN B 5 701 UMP B S 9 FT #HET 551 551 HIS B 5 701 UMP B S 5 FT #HET 553 553 TYR B 5 701 UMP B S 2 FT #HET 553 553 TYR B 8 704 1UE B S 2 FT #HET 608 608 MET B 8 704 1UE B S 6 FT #HET 609 609 ALA B 8 704 1UE B B 1 FT DISORDER 1 2 FT DISORDER 42 73 FT DISORDER 108 125 FT DISORDER 152 152 FT DISORDER 197 223 FT DISORDER 252 284 FT DISORDER 302 307 CC SEQUENCE 491 AA (ATOM); CC KPVCLVVAMT PKRGIGINNG LPWPHLTTDF KHFSRVTKTF NAVVMGRKTW ESMPRKFRPL CC VDRLNIVVSS SLKVCASLPA ALSLLEEEYK DSVDQIFVVG AGLYEAALSL GVASHLYITR CC VAREFPCDVF FPAFPGDDIL SNKEATYRPI FISKTFSDNG VPYDFVVLEK RSSAAAIAPV CC LAWMDEEDKE LIRAVPHVHF RGHEEFQYLD LIADIINNGR TMDDRTGVGV ISKFGCTMRY CC SLDQAFPLLT TKRVFWKGVL EELLWFIRGD TNANHLSEKG VKIWDKNVTR EFLDSRNLPH CC REVGDIGPGY GFQWRHFGAA YKDMHTDYTG QGVDQLKNVI QMLRTNPTDR RMLMTAWNPA CC ALDEMALPPC HLLCQFYVND QKELSCIMYQ RSCDVGLGVP FNIASYSLLT LMVAHVCNLK CC PKEFIHFMGN THVYTNHVEA LKEQLRREPR PFPIVNILNK ERIKEIDDFT AEDFEVVGYV CC PHGRIQMEMA V CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLN CC ATOM --KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKT--------- CC *************************************** CC SEQRES GWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNI CC ATOM -----------------------FNAVVMGRKTWESMPRKFRPLVDRLNI CC *************************** CC SEQRES VVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFV CC ATOM VVSSSLK------------------VCASLPAALSLLEEEYKDSVDQIFV CC ******* ************************* CC SEQRES VGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAA CC ATOM V-GAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNK---- CC * ******************************************** CC SEQRES QAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEK CC ATOM -----------------------EATYRPIFISKTFSDNGVPYDFVVLEK CC *************************** CC SEQRES RRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEE CC ATOM R---------------------------------SSAAAIAPVLAWMDEE CC * **************** CC SEQRES DRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVI CC ATOM D------KELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVI CC * ******************************************* CC SEQRES SKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGV CC ATOM SKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGV CC ************************************************** CC SEQRES KIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQ CC ATOM KIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQ CC ************************************************** CC SEQRES GVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQ CC ATOM GVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQ CC ************************************************** CC SEQRES KELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNT CC ATOM KELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNT CC ************************************************** CC SEQRES HVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP CC ATOM HVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP CC ************************************************** CC SEQRES HGRIQMEMAV CC ATOM HGRIQMEMAV CC ********** SQ SEQUENCE 610 AA; MW; CN; MQKPVCLVVA MTPKRGIGIN NGLPWPHLTT DFKHFSRVTK TTPEEASRLN GWLPRKFAKT GDSGLPSPSV GKRFNAVVMG RKTWESMPRK FRPLVDRLNI VVSSSLKEED IAAEKPQAEG QQRVRVCASL PAALSLLEEE YKDSVDQIFV VGGAGLYEAA LSLGVASHLY ITRVAREFPC DVFFPAFPGD DILSNKSTAA QAAAPAESVF VPFCPELGRE KDNEATYRPI FISKTFSDNG VPYDFVVLEK RRKTDDAATA EPSNAMSSLT STRETTPVHG LQAPSSAAAI APVLAWMDEE DRKKREQKEL IRAVPHVHFR GHEEFQYLDL IADIINNGRT MDDRTGVGVI SKFGCTMRYS LDQAFPLLTT KRVFWKGVLE ELLWFIRGDT NANHLSEKGV KIWDKNVTRE FLDSRNLPHR EVGDIGPGYG FQWRHFGAAY KDMHTDYTGQ GVDQLKNVIQ MLRTNPTDRR MLMTAWNPAA LDEMALPPCH LLCQFYVNDQ KELSCIMYQR SCDVGLGVPF NIASYSLLTL MVAHVCNLKP KEFIHFMGNT HVYTNHVEAL KEQLRREPRP FPIVNILNKE RIKEIDDFTA EDFEVVGYVP HGRIQMEMAV // ID 4KY4C STANDARD; PRT; 610 AA. DT CONVERTED FROM PDB (SEQRES) 4KY4 DE Bifunctional dihydrofolate reductase-thymidylate synthase OS Toxoplasma gondii CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.790 CC R-Factor 0.222 FT #SUB 14 14 LYS C 591 591 GLU B Protein S 5 FT #SUB 15 15 ARG C 397 397 GLU B Protein S 1 FT #SUB 19 19 ILE C 581 581 ARG B Protein S 3 FT #SUB 20 20 ASN C 581 581 ARG B Protein S 2 FT #SUB 178 178 PHE C 591 591 GLU B Protein B 2 FT #SUB 179 179 PRO C 578 578 ASN B Protein S 1 FT #SUB 179 179 PRO C 581 581 ARG B Protein S 1 FT #SUB 179 179 PRO C 589 589 THR B Protein A 2 FT #SUB 179 179 PRO C 591 591 GLU B Protein A 6 FT #SUB 179 179 PRO C 592 592 ASP B Protein S 1 FT #SUB 180 180 CYS C 589 589 THR B Protein B 1 FT #SUB 397 397 GLU C 15 15 ARG B Protein S 1 FT #SUB 397 397 GLU C 196 196 LYS B Protein A 2 FT #SUB 578 578 ASN C 179 179 PRO B Protein S 1 FT #SUB 581 581 ARG C 19 19 ILE B Protein S 4 FT #SUB 581 581 ARG C 20 20 ASN B Protein S 2 FT #SUB 581 581 ARG C 179 179 PRO B Protein S 1 FT #SUB 589 589 THR C 179 179 PRO B Protein S 2 FT #SUB 589 589 THR C 180 180 CYS B Protein S 1 FT #SUB 591 591 GLU C 14 14 LYS B Protein S 4 FT #SUB 591 591 GLU C 177 177 GLU B Protein S 2 FT #SUB 591 591 GLU C 178 178 PHE B Protein S 3 FT #SUB 591 591 GLU C 179 179 PRO B Protein S 4 FT #SUB 592 592 ASP C 179 179 PRO B Protein S 2 FT #SUB 30 30 THR C 296 296 TRP D Protein S 2 FT #SUB 34 34 HIS C 293 293 VAL D Protein S 2 FT #SUB 34 34 HIS C 296 296 TRP D Protein A 8 FT #SUB 37 37 ARG C 296 296 TRP D Protein S 2 FT #SUB 37 37 ARG C 299 299 GLU D Protein S 5 FT #SUB 38 38 VAL C 293 293 VAL D Protein S 1 FT #SUB 168 168 HIS C 285 285 SER D Protein S 2 FT #SUB 170 170 TYR C 289 289 ALA D Protein S 6 FT #SUB 170 170 TYR C 293 293 VAL D Protein S 2 FT #SUB 230 230 ILE C 290 290 ILE D Protein S 1 FT #SUB 231 231 PHE C 290 290 ILE D Protein S 2 FT #SUB 231 231 PHE C 293 293 VAL D Protein S 3 FT #SUB 231 231 PHE C 297 297 MET D Protein S 1 FT #SUB 233 233 SER C 297 297 MET D Protein S 1 FT #SUB 245 245 PHE C 296 296 TRP D Protein S 2 FT #SUB 245 245 PHE C 297 297 MET D Protein S 1 FT #SUB 249 249 GLU C 286 286 SER D Protein S 1 FT #SUB 286 286 SER C 249 249 GLU D Protein B 1 FT #SUB 289 289 ALA C 170 170 TYR D Protein A 6 FT #SUB 290 290 ILE C 230 230 ILE D Protein S 2 FT #SUB 290 290 ILE C 231 231 PHE D Protein S 1 FT #SUB 290 290 ILE C 319 319 PHE D Protein S 7 FT #SUB 293 293 VAL C 170 170 TYR D Protein S 1 FT #SUB 293 293 VAL C 231 231 PHE D Protein S 2 FT #SUB 294 294 LEU C 319 319 PHE D Protein S 1 FT #SUB 296 296 TRP C 30 30 THR D Protein S 2 FT #SUB 296 296 TRP C 34 34 HIS D Protein S 9 FT #SUB 296 296 TRP C 37 37 ARG D Protein S 2 FT #SUB 296 296 TRP C 245 245 PHE D Protein S 3 FT #SUB 297 297 MET C 231 231 PHE D Protein S 1 FT #SUB 297 297 MET C 233 233 SER D Protein S 1 FT #SUB 297 297 MET C 245 245 PHE D Protein S 1 FT #SUB 319 319 PHE C 290 290 ILE D Protein S 5 FT #SUB 319 319 PHE C 294 294 LEU D Protein S 3 FT #SUB 339 339 ARG C 499 499 ASP D Protein S 4 FT #SUB 341 341 MET C 467 467 THR D Protein S 1 FT #SUB 341 341 MET C 498 498 ASN D Protein S 1 FT #SUB 341 341 MET C 499 499 ASP D Protein S 2 FT #SUB 342 342 ASP C 467 467 THR D Protein B 3 FT #SUB 343 343 ASP C 469 469 ARG D Protein S 4 FT #SUB 349 349 VAL C 469 469 ARG D Protein S 1 FT #SUB 351 351 SER C 496 496 TYR D Protein A 5 FT #SUB 353 353 PHE C 358 358 ARG D Protein B 3 FT #SUB 353 353 PHE C 494 494 GLN D Protein S 5 FT #SUB 353 353 PHE C 495 495 PHE D Protein S 1 FT #SUB 353 353 PHE C 496 496 TYR D Protein S 16 FT #SUB 353 353 PHE C 504 504 SER D Protein S 1 FT #SUB 353 353 PHE C 506 506 ILE D Protein S 7 FT #SUB 353 353 PHE C 544 544 ILE D Protein A 2 FT #SUB 354 354 GLY C 358 358 ARG D Protein B 4 FT #SUB 354 354 GLY C 506 506 ILE D Protein B 2 FT #SUB 354 354 GLY C 546 546 PHE D Protein B 1 FT #SUB 356 356 THR C 356 356 THR D Protein S 1 FT #SUB 358 358 ARG C 353 353 PHE D Protein S 1 FT #SUB 358 358 ARG C 354 354 GLY D Protein S 2 FT #SUB 436 436 PHE C 477 477 ASN D Protein S 1 FT #SUB 436 436 PHE C 478 478 PRO D Protein S 2 FT #SUB 452 452 VAL C 478 478 PRO D Protein S 1 FT #SUB 454 454 GLN C 478 478 PRO D Protein S 2 FT #SUB 467 467 THR C 341 341 MET D Protein S 1 FT #SUB 467 467 THR C 342 342 ASP D Protein S 3 FT #SUB 469 469 ARG C 343 343 ASP D Protein S 8 FT #SUB 469 469 ARG C 349 349 VAL D Protein S 1 FT #SUB 469 469 ARG C 510 510 ARG D Protein A 5 FT #SUB 469 469 ARG C 511 511 SER D Protein S 3 FT #SUB 469 469 ARG C 549 549 ASN D Protein S 5 FT #SUB 469 469 ARG C 551 551 HIS D Protein S 5 FT #SUB 469 469 ARG C 553 553 TYR D Protein S 1 FT #SUB 470 470 ARG C 415 415 ARG D Protein S 1 FT #SUB 470 470 ARG C 486 486 LEU D Protein S 1 FT #SUB 470 470 ARG C 487 487 PRO D Protein S 6 FT #SUB 470 470 ARG C 510 510 ARG D Protein S 2 FT #SUB 472 472 LEU C 491 491 LEU D Protein S 1 FT #SUB 472 472 LEU C 510 510 ARG D Protein S 2 FT #SUB 476 476 TRP C 470 470 ARG D Protein S 1 FT #SUB 476 476 TRP C 474 474 THR D Protein S 1 FT #SUB 477 477 ASN C 436 436 PHE D Protein S 1 FT #SUB 478 478 PRO C 436 436 PHE D Protein S 9 FT #SUB 478 478 PRO C 452 452 VAL D Protein B 1 FT #SUB 478 478 PRO C 454 454 GLN D Protein S 2 FT #SUB 479 479 ALA C 452 452 VAL D Protein B 1 FT #SUB 486 486 LEU C 470 470 ARG D Protein S 1 FT #SUB 487 487 PRO C 470 470 ARG D Protein S 5 FT #SUB 491 491 LEU C 472 472 LEU D Protein S 1 FT #SUB 491 491 LEU C 492 492 LEU D Protein S 1 FT #SUB 492 492 LEU C 491 491 LEU D Protein S 1 FT #SUB 492 492 LEU C 508 508 TYR D Protein S 1 FT #SUB 494 494 GLN C 353 353 PHE D Protein B 3 FT #SUB 494 494 GLN C 508 508 TYR D Protein S 5 FT #SUB 494 494 GLN C 510 510 ARG D Protein S 9 FT #SUB 494 494 GLN C 548 548 GLY D Protein S 1 FT #SUB 495 495 PHE C 353 353 PHE D Protein B 1 FT #SUB 496 496 TYR C 351 351 SER D Protein S 5 FT #SUB 496 496 TYR C 353 353 PHE D Protein S 13 FT #SUB 496 496 TYR C 549 549 ASN D Protein S 2 FT #SUB 497 497 VAL C 341 341 MET D Protein B 1 FT #SUB 498 498 ASN C 341 341 MET D Protein B 2 FT #SUB 499 499 ASP C 339 339 ARG D Protein S 3 FT #SUB 499 499 ASP C 341 341 MET D Protein B 2 FT #SUB 504 504 SER C 353 353 PHE D Protein A 2 FT #SUB 506 506 ILE C 353 353 PHE D Protein A 7 FT #SUB 506 506 ILE C 354 354 GLY D Protein S 2 FT #SUB 506 506 ILE C 508 508 TYR D Protein S 2 FT #SUB 508 508 TYR C 492 492 LEU D Protein S 3 FT #SUB 508 508 TYR C 494 494 GLN D Protein S 5 FT #SUB 508 508 TYR C 506 506 ILE D Protein S 2 FT #SUB 508 508 TYR C 546 546 PHE D Protein S 2 FT #SUB 510 510 ARG C 469 469 ARG D Protein S 4 FT #SUB 510 510 ARG C 470 470 ARG D Protein S 3 FT #SUB 510 510 ARG C 494 494 GLN D Protein A 8 FT #SUB 511 511 SER C 469 469 ARG D Protein S 4 FT #SUB 544 544 ILE C 353 353 PHE D Protein S 2 FT #SUB 546 546 PHE C 354 354 GLY D Protein S 1 FT #SUB 546 546 PHE C 355 355 CYS D Protein S 1 FT #SUB 546 546 PHE C 356 356 THR D Protein S 1 FT #SUB 546 546 PHE C 508 508 TYR D Protein S 2 FT #SUB 546 546 PHE C 546 546 PHE D Protein S 4 FT #SUB 547 547 MET C 546 546 PHE D Protein B 1 FT #SUB 548 548 GLY C 494 494 GLN D Protein B 1 FT #SUB 548 548 GLY C 506 506 ILE D Protein B 1 FT #SUB 549 549 ASN C 469 469 ARG D Protein S 6 FT #SUB 549 549 ASN C 494 494 GLN D Protein B 1 FT #SUB 549 549 ASN C 496 496 TYR D Protein S 2 FT #SUB 551 551 HIS C 469 469 ARG D Protein S 9 FT #SUB 553 553 TYR C 469 469 ARG D Protein S 3 FT #HET 8 8 VAL C 10 702 04J C A 5 FT #HET 9 9 VAL C 10 702 04J C B 7 FT #HET 9 9 VAL C 11 703 NDP C A 4 FT #HET 10 10 ALA C 10 702 04J C A 4 FT #HET 10 10 ALA C 11 703 NDP C B 8 FT #HET 17 17 ILE C 11 703 NDP C A 6 FT #HET 18 18 GLY C 11 703 NDP C B 2 FT #HET 19 19 ILE C 11 703 NDP C B 1 FT #HET 21 21 ASN C 11 703 NDP C A 8 FT #HET 22 22 GLY C 11 703 NDP C B 11 FT #HET 23 23 LEU C 11 703 NDP C A 3 FT #HET 25 25 TRP C 10 702 04J C S 1 FT #HET 25 25 TRP C 11 703 NDP C S 1 FT #HET 31 31 ASP C 10 702 04J C S 10 FT #HET 32 32 PHE C 10 702 04J C S 12 FT #HET 35 35 PHE C 10 702 04J C S 7 FT #HET 36 36 SER C 10 702 04J C A 5 FT #HET 80 80 GLY C 11 703 NDP C B 4 FT #HET 81 81 ARG C 11 703 NDP C A 14 FT #HET 82 82 LYS C 11 703 NDP C A 10 FT #HET 83 83 THR C 11 703 NDP C A 9 FT #HET 86 86 SER C 11 703 NDP C S 4 FT #HET 91 91 PHE C 10 702 04J C S 11 FT #HET 94 94 LEU C 10 702 04J C S 2 FT #HET 97 97 ARG C 10 702 04J C S 5 FT #HET 102 102 VAL C 11 703 NDP C B 4 FT #HET 103 103 SER C 11 703 NDP C A 6 FT #HET 104 104 SER C 11 703 NDP C A 7 FT #HET 151 151 VAL C 11 703 NDP C B 2 FT #HET 153 153 GLY C 11 703 NDP C B 11 FT #HET 154 154 ALA C 11 703 NDP C A 12 FT #HET 155 155 GLY C 11 703 NDP C B 3 FT #HET 156 156 LEU C 11 703 NDP C B 3 FT #HET 157 157 TYR C 11 703 NDP C S 2 FT #HET 159 159 ALA C 11 703 NDP C S 1 FT #HET 172 172 THR C 10 702 04J C S 1 FT #HET 182 182 VAL C 11 703 NDP C S 2 FT #HET 381 381 GLU C 12 704 1UE C S 2 FT #HET 402 402 ILE C 12 704 1UE C A 5 FT #HET 403 403 TRP C 12 704 1UE C S 5 FT #HET 406 406 ASN C 12 704 1UE C S 1 FT #HET 429 429 TYR C 9 701 UMP C S 1 FT #HET 469 469 ARG C 13 701 UMP D S 13 FT #HET 470 470 ARG C 13 701 UMP D S 3 FT #HET 489 489 CYS C 9 701 UMP C S 11 FT #HET 490 490 HIS C 9 701 UMP C S 3 FT #HET 509 509 GLN C 9 701 UMP C S 3 FT #HET 510 510 ARG C 9 701 UMP C S 6 FT #HET 511 511 SER C 9 701 UMP C A 12 FT #HET 512 512 CYS C 9 701 UMP C B 2 FT #HET 513 513 ASP C 9 701 UMP C A 4 FT #HET 513 513 ASP C 12 704 1UE C S 4 FT #HET 516 516 LEU C 12 704 1UE C A 17 FT #HET 517 517 GLY C 9 701 UMP C B 1 FT #HET 517 517 GLY C 12 704 1UE C B 7 FT #HET 521 521 ASN C 9 701 UMP C S 7 FT #HET 551 551 HIS C 9 701 UMP C S 6 FT #HET 553 553 TYR C 9 701 UMP C S 3 FT #HET 608 608 MET C 12 704 1UE C S 5 FT #HET 609 609 ALA C 12 704 1UE C B 2 FT DISORDER 1 2 FT DISORDER 42 73 FT DISORDER 108 125 FT DISORDER 152 152 FT DISORDER 197 223 FT DISORDER 252 284 FT DISORDER 300 307 CC SEQUENCE 489 AA (ATOM); CC KPVCLVVAMT PKRGIGINNG LPWPHLTTDF KHFSRVTKTF NAVVMGRKTW ESMPRKFRPL CC VDRLNIVVSS SLKVCASLPA ALSLLEEEYK DSVDQIFVVG AGLYEAALSL GVASHLYITR CC VAREFPCDVF FPAFPGDDIL SNKEATYRPI FISKTFSDNG VPYDFVVLEK RSSAAAIAPV CC LAWMDEKELI RAVPHVHFRG HEEFQYLDLI ADIINNGRTM DDRTGVGVIS KFGCTMRYSL CC DQAFPLLTTK RVFWKGVLEE LLWFIRGDTN ANHLSEKGVK IWDKNVTREF LDSRNLPHRE CC VGDIGPGYGF QWRHFGAAYK DMHTDYTGQG VDQLKNVIQM LRTNPTDRRM LMTAWNPAAL CC DEMALPPCHL LCQFYVNDQK ELSCIMYQRS CDVGLGVPFN IASYSLLTLM VAHVCNLKPK CC EFIHFMGNTH VYTNHVEALK EQLRREPRPF PIVNILNKER IKEIDDFTAE DFEVVGYVPH CC GRIQMEMAV CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLN CC ATOM --KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKT--------- CC *************************************** CC SEQRES GWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNI CC ATOM -----------------------FNAVVMGRKTWESMPRKFRPLVDRLNI CC *************************** CC SEQRES VVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFV CC ATOM VVSSSLK------------------VCASLPAALSLLEEEYKDSVDQIFV CC ******* ************************* CC SEQRES VGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAA CC ATOM V-GAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNK---- CC * ******************************************** CC SEQRES QAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEK CC ATOM -----------------------EATYRPIFISKTFSDNGVPYDFVVLEK CC *************************** CC SEQRES RRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEE CC ATOM R---------------------------------SSAAAIAPVLAWMDE- CC * *************** CC SEQRES DRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVI CC ATOM -------KELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVI CC ******************************************* CC SEQRES SKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGV CC ATOM SKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGV CC ************************************************** CC SEQRES KIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQ CC ATOM KIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQ CC ************************************************** CC SEQRES GVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQ CC ATOM GVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQ CC ************************************************** CC SEQRES KELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNT CC ATOM KELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNT CC ************************************************** CC SEQRES HVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP CC ATOM HVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP CC ************************************************** CC SEQRES HGRIQMEMAV CC ATOM HGRIQMEMAV CC ********** SQ SEQUENCE 610 AA; MW; CN; MQKPVCLVVA MTPKRGIGIN NGLPWPHLTT DFKHFSRVTK TTPEEASRLN GWLPRKFAKT GDSGLPSPSV GKRFNAVVMG RKTWESMPRK FRPLVDRLNI VVSSSLKEED IAAEKPQAEG QQRVRVCASL PAALSLLEEE YKDSVDQIFV VGGAGLYEAA LSLGVASHLY ITRVAREFPC DVFFPAFPGD DILSNKSTAA QAAAPAESVF VPFCPELGRE KDNEATYRPI FISKTFSDNG VPYDFVVLEK RRKTDDAATA EPSNAMSSLT STRETTPVHG LQAPSSAAAI APVLAWMDEE DRKKREQKEL IRAVPHVHFR GHEEFQYLDL IADIINNGRT MDDRTGVGVI SKFGCTMRYS LDQAFPLLTT KRVFWKGVLE ELLWFIRGDT NANHLSEKGV KIWDKNVTRE FLDSRNLPHR EVGDIGPGYG FQWRHFGAAY KDMHTDYTGQ GVDQLKNVIQ MLRTNPTDRR MLMTAWNPAA LDEMALPPCH LLCQFYVNDQ KELSCIMYQR SCDVGLGVPF NIASYSLLTL MVAHVCNLKP KEFIHFMGNT HVYTNHVEAL KEQLRREPRP FPIVNILNKE RIKEIDDFTA EDFEVVGYVP HGRIQMEMAV // ID 4KY4D STANDARD; PRT; 610 AA. DT CONVERTED FROM PDB (SEQRES) 4KY4 DE Bifunctional dihydrofolate reductase-thymidylate synthase OS Toxoplasma gondii CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.790 CC R-Factor 0.222 FT #SUB 30 30 THR D 296 296 TRP C Protein S 2 FT #SUB 34 34 HIS D 296 296 TRP C Protein A 9 FT #SUB 37 37 ARG D 296 296 TRP C Protein S 2 FT #SUB 170 170 TYR D 289 289 ALA C Protein S 6 FT #SUB 170 170 TYR D 293 293 VAL C Protein S 1 FT #SUB 230 230 ILE D 290 290 ILE C Protein S 2 FT #SUB 231 231 PHE D 290 290 ILE C Protein S 1 FT #SUB 231 231 PHE D 293 293 VAL C Protein S 2 FT #SUB 231 231 PHE D 297 297 MET C Protein S 1 FT #SUB 233 233 SER D 297 297 MET C Protein S 1 FT #SUB 245 245 PHE D 296 296 TRP C Protein S 3 FT #SUB 245 245 PHE D 297 297 MET C Protein S 1 FT #SUB 249 249 GLU D 286 286 SER C Protein S 1 FT #SUB 285 285 SER D 168 168 HIS C Protein B 2 FT #SUB 286 286 SER D 249 249 GLU C Protein S 1 FT #SUB 289 289 ALA D 170 170 TYR C Protein A 6 FT #SUB 290 290 ILE D 230 230 ILE C Protein S 1 FT #SUB 290 290 ILE D 231 231 PHE C Protein S 2 FT #SUB 290 290 ILE D 319 319 PHE C Protein S 5 FT #SUB 293 293 VAL D 34 34 HIS C Protein S 2 FT #SUB 293 293 VAL D 38 38 VAL C Protein S 1 FT #SUB 293 293 VAL D 170 170 TYR C Protein S 2 FT #SUB 293 293 VAL D 231 231 PHE C Protein S 3 FT #SUB 294 294 LEU D 319 319 PHE C Protein S 3 FT #SUB 296 296 TRP D 30 30 THR C Protein S 2 FT #SUB 296 296 TRP D 34 34 HIS C Protein S 8 FT #SUB 296 296 TRP D 37 37 ARG C Protein S 2 FT #SUB 296 296 TRP D 245 245 PHE C Protein S 2 FT #SUB 297 297 MET D 231 231 PHE C Protein S 1 FT #SUB 297 297 MET D 233 233 SER C Protein S 1 FT #SUB 297 297 MET D 245 245 PHE C Protein S 1 FT #SUB 299 299 GLU D 37 37 ARG C Protein S 5 FT #SUB 319 319 PHE D 290 290 ILE C Protein S 7 FT #SUB 319 319 PHE D 294 294 LEU C Protein S 1 FT #SUB 339 339 ARG D 499 499 ASP C Protein S 3 FT #SUB 341 341 MET D 467 467 THR C Protein S 1 FT #SUB 341 341 MET D 497 497 VAL C Protein S 1 FT #SUB 341 341 MET D 498 498 ASN C Protein S 2 FT #SUB 341 341 MET D 499 499 ASP C Protein S 2 FT #SUB 342 342 ASP D 467 467 THR C Protein B 3 FT #SUB 343 343 ASP D 469 469 ARG C Protein S 8 FT #SUB 349 349 VAL D 469 469 ARG C Protein S 1 FT #SUB 351 351 SER D 496 496 TYR C Protein A 5 FT #SUB 353 353 PHE D 358 358 ARG C Protein B 1 FT #SUB 353 353 PHE D 494 494 GLN C Protein S 3 FT #SUB 353 353 PHE D 495 495 PHE C Protein S 1 FT #SUB 353 353 PHE D 496 496 TYR C Protein S 13 FT #SUB 353 353 PHE D 504 504 SER C Protein S 2 FT #SUB 353 353 PHE D 506 506 ILE C Protein S 7 FT #SUB 353 353 PHE D 544 544 ILE C Protein A 2 FT #SUB 354 354 GLY D 358 358 ARG C Protein B 2 FT #SUB 354 354 GLY D 506 506 ILE C Protein B 2 FT #SUB 354 354 GLY D 546 546 PHE C Protein B 1 FT #SUB 355 355 CYS D 546 546 PHE C Protein B 1 FT #SUB 356 356 THR D 356 356 THR C Protein S 1 FT #SUB 356 356 THR D 546 546 PHE C Protein S 1 FT #SUB 358 358 ARG D 353 353 PHE C Protein S 3 FT #SUB 358 358 ARG D 354 354 GLY C Protein S 4 FT #SUB 415 415 ARG D 470 470 ARG C Protein S 1 FT #SUB 436 436 PHE D 477 477 ASN C Protein S 1 FT #SUB 436 436 PHE D 478 478 PRO C Protein S 9 FT #SUB 452 452 VAL D 478 478 PRO C Protein S 1 FT #SUB 452 452 VAL D 479 479 ALA C Protein S 1 FT #SUB 454 454 GLN D 478 478 PRO C Protein S 2 FT #SUB 467 467 THR D 341 341 MET C Protein S 1 FT #SUB 467 467 THR D 342 342 ASP C Protein S 3 FT #SUB 469 469 ARG D 343 343 ASP C Protein S 4 FT #SUB 469 469 ARG D 349 349 VAL C Protein S 1 FT #SUB 469 469 ARG D 510 510 ARG C Protein A 4 FT #SUB 469 469 ARG D 511 511 SER C Protein S 4 FT #SUB 469 469 ARG D 549 549 ASN C Protein S 6 FT #SUB 469 469 ARG D 551 551 HIS C Protein S 9 FT #SUB 469 469 ARG D 553 553 TYR C Protein S 3 FT #SUB 470 470 ARG D 476 476 TRP C Protein S 1 FT #SUB 470 470 ARG D 486 486 LEU C Protein S 1 FT #SUB 470 470 ARG D 487 487 PRO C Protein S 5 FT #SUB 470 470 ARG D 510 510 ARG C Protein S 3 FT #SUB 472 472 LEU D 491 491 LEU C Protein S 1 FT #SUB 474 474 THR D 476 476 TRP C Protein S 1 FT #SUB 477 477 ASN D 436 436 PHE C Protein S 1 FT #SUB 478 478 PRO D 436 436 PHE C Protein S 2 FT #SUB 478 478 PRO D 452 452 VAL C Protein B 1 FT #SUB 478 478 PRO D 454 454 GLN C Protein S 2 FT #SUB 486 486 LEU D 470 470 ARG C Protein S 1 FT #SUB 487 487 PRO D 470 470 ARG C Protein S 6 FT #SUB 491 491 LEU D 472 472 LEU C Protein S 1 FT #SUB 491 491 LEU D 492 492 LEU C Protein S 1 FT #SUB 492 492 LEU D 491 491 LEU C Protein S 1 FT #SUB 492 492 LEU D 508 508 TYR C Protein S 3 FT #SUB 494 494 GLN D 353 353 PHE C Protein A 5 FT #SUB 494 494 GLN D 508 508 TYR C Protein S 5 FT #SUB 494 494 GLN D 510 510 ARG C Protein S 8 FT #SUB 494 494 GLN D 548 548 GLY C Protein S 1 FT #SUB 494 494 GLN D 549 549 ASN C Protein S 1 FT #SUB 495 495 PHE D 353 353 PHE C Protein B 1 FT #SUB 496 496 TYR D 351 351 SER C Protein S 5 FT #SUB 496 496 TYR D 353 353 PHE C Protein S 16 FT #SUB 496 496 TYR D 549 549 ASN C Protein S 2 FT #SUB 498 498 ASN D 341 341 MET C Protein B 1 FT #SUB 499 499 ASP D 339 339 ARG C Protein S 4 FT #SUB 499 499 ASP D 341 341 MET C Protein A 2 FT #SUB 504 504 SER D 353 353 PHE C Protein S 1 FT #SUB 506 506 ILE D 353 353 PHE C Protein A 7 FT #SUB 506 506 ILE D 354 354 GLY C Protein S 2 FT #SUB 506 506 ILE D 508 508 TYR C Protein S 2 FT #SUB 506 506 ILE D 548 548 GLY C Protein S 1 FT #SUB 508 508 TYR D 492 492 LEU C Protein S 1 FT #SUB 508 508 TYR D 494 494 GLN C Protein S 5 FT #SUB 508 508 TYR D 506 506 ILE C Protein S 2 FT #SUB 508 508 TYR D 546 546 PHE C Protein S 2 FT #SUB 510 510 ARG D 469 469 ARG C Protein S 5 FT #SUB 510 510 ARG D 470 470 ARG C Protein S 2 FT #SUB 510 510 ARG D 472 472 LEU C Protein S 2 FT #SUB 510 510 ARG D 494 494 GLN C Protein A 9 FT #SUB 511 511 SER D 469 469 ARG C Protein S 3 FT #SUB 544 544 ILE D 353 353 PHE C Protein S 2 FT #SUB 546 546 PHE D 354 354 GLY C Protein S 1 FT #SUB 546 546 PHE D 508 508 TYR C Protein S 2 FT #SUB 546 546 PHE D 546 546 PHE C Protein S 4 FT #SUB 546 546 PHE D 547 547 MET C Protein S 1 FT #SUB 548 548 GLY D 494 494 GLN C Protein B 1 FT #SUB 549 549 ASN D 469 469 ARG C Protein S 5 FT #SUB 549 549 ASN D 496 496 TYR C Protein S 2 FT #SUB 551 551 HIS D 469 469 ARG C Protein S 5 FT #SUB 553 553 TYR D 469 469 ARG C Protein S 1 FT #HET 8 8 VAL D 14 702 04J D A 3 FT #HET 9 9 VAL D 14 702 04J D B 4 FT #HET 9 9 VAL D 15 703 NDP D A 4 FT #HET 10 10 ALA D 14 702 04J D A 3 FT #HET 10 10 ALA D 15 703 NDP D B 7 FT #HET 17 17 ILE D 15 703 NDP D A 12 FT #HET 18 18 GLY D 15 703 NDP D B 3 FT #HET 19 19 ILE D 15 703 NDP D B 1 FT #HET 21 21 ASN D 15 703 NDP D A 8 FT #HET 22 22 GLY D 15 703 NDP D B 7 FT #HET 23 23 LEU D 15 703 NDP D S 1 FT #HET 25 25 TRP D 15 703 NDP D S 2 FT #HET 31 31 ASP D 14 702 04J D S 5 FT #HET 32 32 PHE D 14 702 04J D A 16 FT #HET 35 35 PHE D 14 702 04J D S 9 FT #HET 36 36 SER D 14 702 04J D A 7 FT #HET 80 80 GLY D 15 703 NDP D B 7 FT #HET 81 81 ARG D 15 703 NDP D A 16 FT #HET 82 82 LYS D 15 703 NDP D A 10 FT #HET 83 83 THR D 15 703 NDP D A 8 FT #HET 86 86 SER D 15 703 NDP D S 4 FT #HET 87 87 MET D 14 702 04J D S 2 FT #HET 91 91 PHE D 14 702 04J D S 7 FT #HET 94 94 LEU D 14 702 04J D S 3 FT #HET 97 97 ARG D 14 702 04J D S 7 FT #HET 102 102 VAL D 15 703 NDP D A 7 FT #HET 103 103 SER D 15 703 NDP D A 8 FT #HET 104 104 SER D 15 703 NDP D A 4 FT #HET 105 105 SER D 15 703 NDP D A 3 FT #HET 128 128 ALA D 15 703 NDP D B 1 FT #HET 153 153 GLY D 15 703 NDP D B 6 FT #HET 154 154 ALA D 15 703 NDP D A 10 FT #HET 155 155 GLY D 15 703 NDP D B 4 FT #HET 156 156 LEU D 15 703 NDP D B 1 FT #HET 157 157 TYR D 15 703 NDP D S 2 FT #HET 182 182 VAL D 15 703 NDP D S 4 FT #HET 381 381 GLU D 16 704 1UE D S 1 FT #HET 402 402 ILE D 16 704 1UE D B 2 FT #HET 403 403 TRP D 16 704 1UE D S 8 FT #HET 406 406 ASN D 16 704 1UE D S 3 FT #HET 429 429 TYR D 13 701 UMP D S 1 FT #HET 469 469 ARG D 9 701 UMP C S 13 FT #HET 470 470 ARG D 9 701 UMP C S 6 FT #HET 489 489 CYS D 13 701 UMP D S 11 FT #HET 490 490 HIS D 13 701 UMP D S 3 FT #HET 509 509 GLN D 13 701 UMP D S 3 FT #HET 510 510 ARG D 13 701 UMP D S 5 FT #HET 511 511 SER D 13 701 UMP D A 10 FT #HET 512 512 CYS D 13 701 UMP D B 2 FT #HET 513 513 ASP D 13 701 UMP D A 4 FT #HET 513 513 ASP D 16 704 1UE D S 4 FT #HET 516 516 LEU D 16 704 1UE D S 7 FT #HET 517 517 GLY D 16 704 1UE D B 2 FT #HET 520 520 PHE D 16 704 1UE D S 2 FT #HET 521 521 ASN D 13 701 UMP D S 9 FT #HET 551 551 HIS D 13 701 UMP D S 4 FT #HET 553 553 TYR D 13 701 UMP D S 1 FT #HET 553 553 TYR D 16 704 1UE D S 2 FT #HET 608 608 MET D 16 704 1UE D S 3 FT #HET 609 609 ALA D 16 704 1UE D B 1 FT DISORDER 1 2 FT DISORDER 42 73 FT DISORDER 108 125 FT DISORDER 152 152 FT DISORDER 197 223 FT DISORDER 252 284 FT DISORDER 302 307 CC SEQUENCE 491 AA (ATOM); CC KPVCLVVAMT PKRGIGINNG LPWPHLTTDF KHFSRVTKTF NAVVMGRKTW ESMPRKFRPL CC VDRLNIVVSS SLKVCASLPA ALSLLEEEYK DSVDQIFVVG AGLYEAALSL GVASHLYITR CC VAREFPCDVF FPAFPGDDIL SNKEATYRPI FISKTFSDNG VPYDFVVLEK RSSAAAIAPV CC LAWMDEEDKE LIRAVPHVHF RGHEEFQYLD LIADIINNGR TMDDRTGVGV ISKFGCTMRY CC SLDQAFPLLT TKRVFWKGVL EELLWFIRGD TNANHLSEKG VKIWDKNVTR EFLDSRNLPH CC REVGDIGPGY GFQWRHFGAA YKDMHTDYTG QGVDQLKNVI QMLRTNPTDR RMLMTAWNPA CC ALDEMALPPC HLLCQFYVND QKELSCIMYQ RSCDVGLGVP FNIASYSLLT LMVAHVCNLK CC PKEFIHFMGN THVYTNHVEA LKEQLRREPR PFPIVNILNK ERIKEIDDFT AEDFEVVGYV CC PHGRIQMEMA V CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLN CC ATOM --KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKT--------- CC *************************************** CC SEQRES GWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNI CC ATOM -----------------------FNAVVMGRKTWESMPRKFRPLVDRLNI CC *************************** CC SEQRES VVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFV CC ATOM VVSSSLK------------------VCASLPAALSLLEEEYKDSVDQIFV CC ******* ************************* CC SEQRES VGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAA CC ATOM V-GAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNK---- CC * ******************************************** CC SEQRES QAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEK CC ATOM -----------------------EATYRPIFISKTFSDNGVPYDFVVLEK CC *************************** CC SEQRES RRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEE CC ATOM R---------------------------------SSAAAIAPVLAWMDEE CC * **************** CC SEQRES DRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVI CC ATOM D------KELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVI CC * ******************************************* CC SEQRES SKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGV CC ATOM SKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGV CC ************************************************** CC SEQRES KIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQ CC ATOM KIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQ CC ************************************************** CC SEQRES GVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQ CC ATOM GVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQ CC ************************************************** CC SEQRES KELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNT CC ATOM KELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNT CC ************************************************** CC SEQRES HVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP CC ATOM HVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP CC ************************************************** CC SEQRES HGRIQMEMAV CC ATOM HGRIQMEMAV CC ********** SQ SEQUENCE 610 AA; MW; CN; MQKPVCLVVA MTPKRGIGIN NGLPWPHLTT DFKHFSRVTK TTPEEASRLN GWLPRKFAKT GDSGLPSPSV GKRFNAVVMG RKTWESMPRK FRPLVDRLNI VVSSSLKEED IAAEKPQAEG QQRVRVCASL PAALSLLEEE YKDSVDQIFV VGGAGLYEAA LSLGVASHLY ITRVAREFPC DVFFPAFPGD DILSNKSTAA QAAAPAESVF VPFCPELGRE KDNEATYRPI FISKTFSDNG VPYDFVVLEK RRKTDDAATA EPSNAMSSLT STRETTPVHG LQAPSSAAAI APVLAWMDEE DRKKREQKEL IRAVPHVHFR GHEEFQYLDL IADIINNGRT MDDRTGVGVI SKFGCTMRYS LDQAFPLLTT KRVFWKGVLE ELLWFIRGDT NANHLSEKGV KIWDKNVTRE FLDSRNLPHR EVGDIGPGYG FQWRHFGAAY KDMHTDYTGQ GVDQLKNVIQ MLRTNPTDRR MLMTAWNPAA LDEMALPPCH LLCQFYVNDQ KELSCIMYQR SCDVGLGVPF NIASYSLLTL MVAHVCNLKP KEFIHFMGNT HVYTNHVEAL KEQLRREPRP FPIVNILNKE RIKEIDDFTA EDFEVVGYVP HGRIQMEMAV // ID 4KY4E STANDARD; PRT; 610 AA. DT CONVERTED FROM PDB (SEQRES) 4KY4 DE Bifunctional dihydrofolate reductase-thymidylate synthase OS Toxoplasma gondii CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.790 CC R-Factor 0.222 FT #SUB 30 30 THR E 296 296 TRP F Protein S 2 FT #SUB 34 34 HIS E 296 296 TRP F Protein A 8 FT #SUB 37 37 ARG E 296 296 TRP F Protein S 1 FT #SUB 37 37 ARG E 299 299 GLU F Protein S 5 FT #SUB 38 38 VAL E 293 293 VAL F Protein S 1 FT #SUB 168 168 HIS E 285 285 SER F Protein S 1 FT #SUB 170 170 TYR E 289 289 ALA F Protein S 6 FT #SUB 170 170 TYR E 293 293 VAL F Protein S 2 FT #SUB 230 230 ILE E 290 290 ILE F Protein S 1 FT #SUB 231 231 PHE E 290 290 ILE F Protein S 2 FT #SUB 231 231 PHE E 293 293 VAL F Protein S 2 FT #SUB 231 231 PHE E 297 297 MET F Protein S 1 FT #SUB 233 233 SER E 297 297 MET F Protein S 1 FT #SUB 245 245 PHE E 297 297 MET F Protein S 1 FT #SUB 249 249 GLU E 286 286 SER F Protein S 1 FT #SUB 285 285 SER E 168 168 HIS F Protein S 1 FT #SUB 286 286 SER E 249 249 GLU F Protein B 1 FT #SUB 289 289 ALA E 170 170 TYR F Protein A 6 FT #SUB 290 290 ILE E 230 230 ILE F Protein S 2 FT #SUB 290 290 ILE E 231 231 PHE F Protein S 1 FT #SUB 290 290 ILE E 319 319 PHE F Protein S 7 FT #SUB 293 293 VAL E 38 38 VAL F Protein S 1 FT #SUB 293 293 VAL E 170 170 TYR F Protein S 1 FT #SUB 293 293 VAL E 231 231 PHE F Protein S 2 FT #SUB 294 294 LEU E 319 319 PHE F Protein S 2 FT #SUB 296 296 TRP E 30 30 THR F Protein S 2 FT #SUB 296 296 TRP E 34 34 HIS F Protein S 6 FT #SUB 296 296 TRP E 37 37 ARG F Protein S 2 FT #SUB 296 296 TRP E 245 245 PHE F Protein S 3 FT #SUB 297 297 MET E 231 231 PHE F Protein S 2 FT #SUB 297 297 MET E 233 233 SER F Protein S 1 FT #SUB 297 297 MET E 245 245 PHE F Protein S 1 FT #SUB 319 319 PHE E 290 290 ILE F Protein S 5 FT #SUB 319 319 PHE E 294 294 LEU F Protein S 3 FT #SUB 339 339 ARG E 499 499 ASP F Protein S 4 FT #SUB 341 341 MET E 497 497 VAL F Protein S 1 FT #SUB 341 341 MET E 498 498 ASN F Protein S 2 FT #SUB 341 341 MET E 499 499 ASP F Protein S 3 FT #SUB 342 342 ASP E 467 467 THR F Protein B 2 FT #SUB 343 343 ASP E 469 469 ARG F Protein S 3 FT #SUB 349 349 VAL E 469 469 ARG F Protein S 1 FT #SUB 351 351 SER E 496 496 TYR F Protein A 5 FT #SUB 353 353 PHE E 358 358 ARG F Protein B 3 FT #SUB 353 353 PHE E 494 494 GLN F Protein S 5 FT #SUB 353 353 PHE E 496 496 TYR F Protein S 16 FT #SUB 353 353 PHE E 504 504 SER F Protein S 1 FT #SUB 353 353 PHE E 506 506 ILE F Protein S 7 FT #SUB 353 353 PHE E 544 544 ILE F Protein A 2 FT #SUB 354 354 GLY E 358 358 ARG F Protein B 4 FT #SUB 354 354 GLY E 506 506 ILE F Protein B 2 FT #SUB 354 354 GLY E 546 546 PHE F Protein B 1 FT #SUB 355 355 CYS E 546 546 PHE F Protein B 1 FT #SUB 356 356 THR E 356 356 THR F Protein S 1 FT #SUB 358 358 ARG E 353 353 PHE F Protein S 1 FT #SUB 358 358 ARG E 354 354 GLY F Protein S 3 FT #SUB 415 415 ARG E 470 470 ARG F Protein S 1 FT #SUB 436 436 PHE E 477 477 ASN F Protein S 1 FT #SUB 436 436 PHE E 478 478 PRO F Protein S 2 FT #SUB 452 452 VAL E 478 478 PRO F Protein S 1 FT #SUB 454 454 GLN E 478 478 PRO F Protein S 2 FT #SUB 467 467 THR E 341 341 MET F Protein S 1 FT #SUB 467 467 THR E 342 342 ASP F Protein S 2 FT #SUB 469 469 ARG E 343 343 ASP F Protein S 7 FT #SUB 469 469 ARG E 349 349 VAL F Protein S 1 FT #SUB 469 469 ARG E 510 510 ARG F Protein A 5 FT #SUB 469 469 ARG E 511 511 SER F Protein S 3 FT #SUB 469 469 ARG E 549 549 ASN F Protein S 5 FT #SUB 469 469 ARG E 551 551 HIS F Protein S 5 FT #SUB 469 469 ARG E 553 553 TYR F Protein S 3 FT #SUB 470 470 ARG E 415 415 ARG F Protein S 1 FT #SUB 470 470 ARG E 486 486 LEU F Protein S 1 FT #SUB 470 470 ARG E 487 487 PRO F Protein S 6 FT #SUB 470 470 ARG E 510 510 ARG F Protein S 3 FT #SUB 472 472 LEU E 491 491 LEU F Protein S 1 FT #SUB 472 472 LEU E 510 510 ARG F Protein S 1 FT #SUB 476 476 TRP E 474 474 THR F Protein S 1 FT #SUB 477 477 ASN E 436 436 PHE F Protein S 1 FT #SUB 478 478 PRO E 436 436 PHE F Protein S 9 FT #SUB 478 478 PRO E 454 454 GLN F Protein S 2 FT #SUB 486 486 LEU E 470 470 ARG F Protein S 1 FT #SUB 487 487 PRO E 470 470 ARG F Protein S 5 FT #SUB 491 491 LEU E 472 472 LEU F Protein S 1 FT #SUB 491 491 LEU E 492 492 LEU F Protein S 1 FT #SUB 492 492 LEU E 491 491 LEU F Protein S 1 FT #SUB 492 492 LEU E 508 508 TYR F Protein S 1 FT #SUB 494 494 GLN E 353 353 PHE F Protein B 3 FT #SUB 494 494 GLN E 508 508 TYR F Protein S 5 FT #SUB 494 494 GLN E 510 510 ARG F Protein S 8 FT #SUB 494 494 GLN E 548 548 GLY F Protein S 1 FT #SUB 496 496 TYR E 351 351 SER F Protein S 6 FT #SUB 496 496 TYR E 353 353 PHE F Protein S 14 FT #SUB 496 496 TYR E 549 549 ASN F Protein S 2 FT #SUB 497 497 VAL E 341 341 MET F Protein B 1 FT #SUB 498 498 ASN E 341 341 MET F Protein B 4 FT #SUB 499 499 ASP E 339 339 ARG F Protein S 3 FT #SUB 499 499 ASP E 341 341 MET F Protein B 2 FT #SUB 504 504 SER E 353 353 PHE F Protein A 2 FT #SUB 506 506 ILE E 353 353 PHE F Protein A 8 FT #SUB 506 506 ILE E 354 354 GLY F Protein S 2 FT #SUB 506 506 ILE E 508 508 TYR F Protein S 4 FT #SUB 508 508 TYR E 492 492 LEU F Protein S 3 FT #SUB 508 508 TYR E 494 494 GLN F Protein S 5 FT #SUB 508 508 TYR E 506 506 ILE F Protein S 2 FT #SUB 508 508 TYR E 546 546 PHE F Protein S 2 FT #SUB 510 510 ARG E 469 469 ARG F Protein S 4 FT #SUB 510 510 ARG E 470 470 ARG F Protein S 3 FT #SUB 510 510 ARG E 494 494 GLN F Protein A 8 FT #SUB 511 511 SER E 469 469 ARG F Protein S 3 FT #SUB 544 544 ILE E 353 353 PHE F Protein S 2 FT #SUB 546 546 PHE E 354 354 GLY F Protein S 1 FT #SUB 546 546 PHE E 355 355 CYS F Protein S 1 FT #SUB 546 546 PHE E 508 508 TYR F Protein S 3 FT #SUB 547 547 MET E 546 546 PHE F Protein B 1 FT #SUB 548 548 GLY E 494 494 GLN F Protein B 1 FT #SUB 548 548 GLY E 506 506 ILE F Protein B 1 FT #SUB 549 549 ASN E 469 469 ARG F Protein S 5 FT #SUB 549 549 ASN E 494 494 GLN F Protein B 1 FT #SUB 549 549 ASN E 496 496 TYR F Protein S 2 FT #SUB 551 551 HIS E 469 469 ARG F Protein S 7 FT #SUB 553 553 TYR E 469 469 ARG F Protein S 3 FT #HET 8 8 VAL E 18 702 04J E A 6 FT #HET 9 9 VAL E 18 702 04J E B 6 FT #HET 9 9 VAL E 19 703 NDP E B 2 FT #HET 10 10 ALA E 18 702 04J E A 5 FT #HET 10 10 ALA E 19 703 NDP E B 6 FT #HET 17 17 ILE E 19 703 NDP E B 5 FT #HET 18 18 GLY E 19 703 NDP E B 2 FT #HET 19 19 ILE E 19 703 NDP E B 1 FT #HET 21 21 ASN E 19 703 NDP E A 8 FT #HET 22 22 GLY E 19 703 NDP E B 11 FT #HET 23 23 LEU E 19 703 NDP E A 2 FT #HET 25 25 TRP E 18 702 04J E S 1 FT #HET 25 25 TRP E 19 703 NDP E S 1 FT #HET 31 31 ASP E 18 702 04J E S 10 FT #HET 32 32 PHE E 18 702 04J E S 14 FT #HET 35 35 PHE E 18 702 04J E S 6 FT #HET 36 36 SER E 18 702 04J E S 5 FT #HET 80 80 GLY E 19 703 NDP E B 5 FT #HET 81 81 ARG E 19 703 NDP E A 11 FT #HET 82 82 LYS E 19 703 NDP E A 8 FT #HET 83 83 THR E 19 703 NDP E A 9 FT #HET 86 86 SER E 19 703 NDP E S 4 FT #HET 91 91 PHE E 18 702 04J E S 10 FT #HET 94 94 LEU E 18 702 04J E S 3 FT #HET 97 97 ARG E 18 702 04J E S 4 FT #HET 102 102 VAL E 19 703 NDP E B 5 FT #HET 103 103 SER E 19 703 NDP E A 6 FT #HET 104 104 SER E 19 703 NDP E A 4 FT #HET 151 151 VAL E 18 702 04J E B 1 FT #HET 151 151 VAL E 19 703 NDP E B 2 FT #HET 153 153 GLY E 19 703 NDP E B 10 FT #HET 154 154 ALA E 19 703 NDP E A 11 FT #HET 155 155 GLY E 19 703 NDP E B 2 FT #HET 156 156 LEU E 19 703 NDP E B 1 FT #HET 157 157 TYR E 19 703 NDP E S 2 FT #HET 172 172 THR E 18 702 04J E S 1 FT #HET 182 182 VAL E 19 703 NDP E S 3 FT #HET 381 381 GLU E 20 704 1UE E S 2 FT #HET 402 402 ILE E 20 704 1UE E A 6 FT #HET 403 403 TRP E 20 704 1UE E S 5 FT #HET 406 406 ASN E 20 704 1UE E S 1 FT #HET 429 429 TYR E 17 701 UMP E S 1 FT #HET 469 469 ARG E 21 701 UMP F S 12 FT #HET 470 470 ARG E 21 701 UMP F S 5 FT #HET 489 489 CYS E 17 701 UMP E S 11 FT #HET 490 490 HIS E 17 701 UMP E S 3 FT #HET 509 509 GLN E 17 701 UMP E S 3 FT #HET 510 510 ARG E 17 701 UMP E S 7 FT #HET 511 511 SER E 17 701 UMP E A 10 FT #HET 512 512 CYS E 17 701 UMP E B 2 FT #HET 513 513 ASP E 17 701 UMP E A 4 FT #HET 513 513 ASP E 20 704 1UE E S 5 FT #HET 516 516 LEU E 20 704 1UE E A 11 FT #HET 517 517 GLY E 17 701 UMP E B 1 FT #HET 517 517 GLY E 20 704 1UE E B 5 FT #HET 521 521 ASN E 17 701 UMP E S 10 FT #HET 551 551 HIS E 17 701 UMP E S 4 FT #HET 553 553 TYR E 17 701 UMP E S 3 FT #HET 608 608 MET E 20 704 1UE E S 7 FT #HET 609 609 ALA E 20 704 1UE E B 2 FT DISORDER 1 2 FT DISORDER 42 73 FT DISORDER 108 125 FT DISORDER 152 152 FT DISORDER 197 223 FT DISORDER 252 284 FT DISORDER 300 307 CC SEQUENCE 489 AA (ATOM); CC KPVCLVVAMT PKRGIGINNG LPWPHLTTDF KHFSRVTKTF NAVVMGRKTW ESMPRKFRPL CC VDRLNIVVSS SLKVCASLPA ALSLLEEEYK DSVDQIFVVG AGLYEAALSL GVASHLYITR CC VAREFPCDVF FPAFPGDDIL SNKEATYRPI FISKTFSDNG VPYDFVVLEK RSSAAAIAPV CC LAWMDEKELI RAVPHVHFRG HEEFQYLDLI ADIINNGRTM DDRTGVGVIS KFGCTMRYSL CC DQAFPLLTTK RVFWKGVLEE LLWFIRGDTN ANHLSEKGVK IWDKNVTREF LDSRNLPHRE CC VGDIGPGYGF QWRHFGAAYK DMHTDYTGQG VDQLKNVIQM LRTNPTDRRM LMTAWNPAAL CC DEMALPPCHL LCQFYVNDQK ELSCIMYQRS CDVGLGVPFN IASYSLLTLM VAHVCNLKPK CC EFIHFMGNTH VYTNHVEALK EQLRREPRPF PIVNILNKER IKEIDDFTAE DFEVVGYVPH CC GRIQMEMAV CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLN CC ATOM --KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKT--------- CC *************************************** CC SEQRES GWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNI CC ATOM -----------------------FNAVVMGRKTWESMPRKFRPLVDRLNI CC *************************** CC SEQRES VVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFV CC ATOM VVSSSLK------------------VCASLPAALSLLEEEYKDSVDQIFV CC ******* ************************* CC SEQRES VGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAA CC ATOM V-GAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNK---- CC * ******************************************** CC SEQRES QAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEK CC ATOM -----------------------EATYRPIFISKTFSDNGVPYDFVVLEK CC *************************** CC SEQRES RRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEE CC ATOM R---------------------------------SSAAAIAPVLAWMDE- CC * *************** CC SEQRES DRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVI CC ATOM -------KELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVI CC ******************************************* CC SEQRES SKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGV CC ATOM SKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGV CC ************************************************** CC SEQRES KIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQ CC ATOM KIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQ CC ************************************************** CC SEQRES GVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQ CC ATOM GVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQ CC ************************************************** CC SEQRES KELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNT CC ATOM KELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNT CC ************************************************** CC SEQRES HVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP CC ATOM HVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP CC ************************************************** CC SEQRES HGRIQMEMAV CC ATOM HGRIQMEMAV CC ********** SQ SEQUENCE 610 AA; MW; CN; MQKPVCLVVA MTPKRGIGIN NGLPWPHLTT DFKHFSRVTK TTPEEASRLN GWLPRKFAKT GDSGLPSPSV GKRFNAVVMG RKTWESMPRK FRPLVDRLNI VVSSSLKEED IAAEKPQAEG QQRVRVCASL PAALSLLEEE YKDSVDQIFV VGGAGLYEAA LSLGVASHLY ITRVAREFPC DVFFPAFPGD DILSNKSTAA QAAAPAESVF VPFCPELGRE KDNEATYRPI FISKTFSDNG VPYDFVVLEK RRKTDDAATA EPSNAMSSLT STRETTPVHG LQAPSSAAAI APVLAWMDEE DRKKREQKEL IRAVPHVHFR GHEEFQYLDL IADIINNGRT MDDRTGVGVI SKFGCTMRYS LDQAFPLLTT KRVFWKGVLE ELLWFIRGDT NANHLSEKGV KIWDKNVTRE FLDSRNLPHR EVGDIGPGYG FQWRHFGAAY KDMHTDYTGQ GVDQLKNVIQ MLRTNPTDRR MLMTAWNPAA LDEMALPPCH LLCQFYVNDQ KELSCIMYQR SCDVGLGVPF NIASYSLLTL MVAHVCNLKP KEFIHFMGNT HVYTNHVEAL KEQLRREPRP FPIVNILNKE RIKEIDDFTA EDFEVVGYVP HGRIQMEMAV // ID 4KY4F STANDARD; PRT; 610 AA. DT CONVERTED FROM PDB (SEQRES) 4KY4 DE Bifunctional dihydrofolate reductase-thymidylate synthase OS Toxoplasma gondii CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.790 CC R-Factor 0.222 FT #SUB 30 30 THR F 296 296 TRP E Protein S 2 FT #SUB 34 34 HIS F 296 296 TRP E Protein A 6 FT #SUB 37 37 ARG F 296 296 TRP E Protein S 2 FT #SUB 38 38 VAL F 293 293 VAL E Protein S 1 FT #SUB 168 168 HIS F 285 285 SER E Protein S 1 FT #SUB 170 170 TYR F 289 289 ALA E Protein S 6 FT #SUB 170 170 TYR F 293 293 VAL E Protein S 1 FT #SUB 230 230 ILE F 290 290 ILE E Protein S 2 FT #SUB 231 231 PHE F 290 290 ILE E Protein S 1 FT #SUB 231 231 PHE F 293 293 VAL E Protein S 2 FT #SUB 231 231 PHE F 297 297 MET E Protein S 2 FT #SUB 233 233 SER F 297 297 MET E Protein S 1 FT #SUB 245 245 PHE F 296 296 TRP E Protein S 3 FT #SUB 245 245 PHE F 297 297 MET E Protein S 1 FT #SUB 249 249 GLU F 286 286 SER E Protein S 1 FT #SUB 285 285 SER F 168 168 HIS E Protein B 1 FT #SUB 286 286 SER F 249 249 GLU E Protein S 1 FT #SUB 289 289 ALA F 170 170 TYR E Protein A 6 FT #SUB 290 290 ILE F 230 230 ILE E Protein S 1 FT #SUB 290 290 ILE F 231 231 PHE E Protein S 2 FT #SUB 290 290 ILE F 319 319 PHE E Protein S 5 FT #SUB 293 293 VAL F 38 38 VAL E Protein S 1 FT #SUB 293 293 VAL F 170 170 TYR E Protein S 2 FT #SUB 293 293 VAL F 231 231 PHE E Protein S 2 FT #SUB 294 294 LEU F 319 319 PHE E Protein S 3 FT #SUB 296 296 TRP F 30 30 THR E Protein S 2 FT #SUB 296 296 TRP F 34 34 HIS E Protein S 8 FT #SUB 296 296 TRP F 37 37 ARG E Protein S 1 FT #SUB 297 297 MET F 231 231 PHE E Protein S 1 FT #SUB 297 297 MET F 233 233 SER E Protein S 1 FT #SUB 297 297 MET F 245 245 PHE E Protein S 1 FT #SUB 299 299 GLU F 37 37 ARG E Protein S 5 FT #SUB 319 319 PHE F 290 290 ILE E Protein S 7 FT #SUB 319 319 PHE F 294 294 LEU E Protein S 2 FT #SUB 339 339 ARG F 499 499 ASP E Protein S 3 FT #SUB 341 341 MET F 467 467 THR E Protein S 1 FT #SUB 341 341 MET F 497 497 VAL E Protein S 1 FT #SUB 341 341 MET F 498 498 ASN E Protein S 4 FT #SUB 341 341 MET F 499 499 ASP E Protein S 2 FT #SUB 342 342 ASP F 467 467 THR E Protein B 2 FT #SUB 343 343 ASP F 469 469 ARG E Protein S 7 FT #SUB 349 349 VAL F 469 469 ARG E Protein S 1 FT #SUB 351 351 SER F 496 496 TYR E Protein A 6 FT #SUB 353 353 PHE F 358 358 ARG E Protein B 1 FT #SUB 353 353 PHE F 494 494 GLN E Protein S 3 FT #SUB 353 353 PHE F 496 496 TYR E Protein S 14 FT #SUB 353 353 PHE F 504 504 SER E Protein S 2 FT #SUB 353 353 PHE F 506 506 ILE E Protein S 8 FT #SUB 353 353 PHE F 544 544 ILE E Protein A 2 FT #SUB 354 354 GLY F 358 358 ARG E Protein B 3 FT #SUB 354 354 GLY F 506 506 ILE E Protein B 2 FT #SUB 354 354 GLY F 546 546 PHE E Protein B 1 FT #SUB 355 355 CYS F 546 546 PHE E Protein B 1 FT #SUB 356 356 THR F 356 356 THR E Protein S 1 FT #SUB 358 358 ARG F 353 353 PHE E Protein S 3 FT #SUB 358 358 ARG F 354 354 GLY E Protein S 4 FT #SUB 415 415 ARG F 470 470 ARG E Protein S 1 FT #SUB 436 436 PHE F 477 477 ASN E Protein S 1 FT #SUB 436 436 PHE F 478 478 PRO E Protein S 9 FT #SUB 454 454 GLN F 478 478 PRO E Protein S 2 FT #SUB 467 467 THR F 342 342 ASP E Protein S 2 FT #SUB 469 469 ARG F 343 343 ASP E Protein S 3 FT #SUB 469 469 ARG F 349 349 VAL E Protein S 1 FT #SUB 469 469 ARG F 510 510 ARG E Protein A 4 FT #SUB 469 469 ARG F 511 511 SER E Protein S 3 FT #SUB 469 469 ARG F 549 549 ASN E Protein S 5 FT #SUB 469 469 ARG F 551 551 HIS E Protein S 7 FT #SUB 469 469 ARG F 553 553 TYR E Protein S 3 FT #SUB 470 470 ARG F 415 415 ARG E Protein S 1 FT #SUB 470 470 ARG F 486 486 LEU E Protein S 1 FT #SUB 470 470 ARG F 487 487 PRO E Protein S 5 FT #SUB 470 470 ARG F 510 510 ARG E Protein S 3 FT #SUB 472 472 LEU F 491 491 LEU E Protein S 1 FT #SUB 474 474 THR F 476 476 TRP E Protein S 1 FT #SUB 477 477 ASN F 436 436 PHE E Protein S 1 FT #SUB 478 478 PRO F 436 436 PHE E Protein S 2 FT #SUB 478 478 PRO F 452 452 VAL E Protein B 1 FT #SUB 478 478 PRO F 454 454 GLN E Protein S 2 FT #SUB 486 486 LEU F 470 470 ARG E Protein S 1 FT #SUB 487 487 PRO F 470 470 ARG E Protein S 6 FT #SUB 491 491 LEU F 472 472 LEU E Protein S 1 FT #SUB 491 491 LEU F 492 492 LEU E Protein S 1 FT #SUB 492 492 LEU F 491 491 LEU E Protein S 1 FT #SUB 492 492 LEU F 508 508 TYR E Protein S 3 FT #SUB 494 494 GLN F 353 353 PHE E Protein A 5 FT #SUB 494 494 GLN F 508 508 TYR E Protein S 5 FT #SUB 494 494 GLN F 510 510 ARG E Protein S 8 FT #SUB 494 494 GLN F 548 548 GLY E Protein S 1 FT #SUB 494 494 GLN F 549 549 ASN E Protein S 1 FT #SUB 496 496 TYR F 351 351 SER E Protein S 5 FT #SUB 496 496 TYR F 353 353 PHE E Protein S 16 FT #SUB 496 496 TYR F 549 549 ASN E Protein S 2 FT #SUB 497 497 VAL F 341 341 MET E Protein B 1 FT #SUB 498 498 ASN F 341 341 MET E Protein B 2 FT #SUB 499 499 ASP F 339 339 ARG E Protein S 4 FT #SUB 499 499 ASP F 341 341 MET E Protein A 3 FT #SUB 504 504 SER F 353 353 PHE E Protein S 1 FT #SUB 506 506 ILE F 353 353 PHE E Protein A 7 FT #SUB 506 506 ILE F 354 354 GLY E Protein S 2 FT #SUB 506 506 ILE F 508 508 TYR E Protein S 2 FT #SUB 506 506 ILE F 548 548 GLY E Protein S 1 FT #SUB 508 508 TYR F 492 492 LEU E Protein S 1 FT #SUB 508 508 TYR F 494 494 GLN E Protein S 5 FT #SUB 508 508 TYR F 506 506 ILE E Protein S 4 FT #SUB 508 508 TYR F 546 546 PHE E Protein S 3 FT #SUB 510 510 ARG F 469 469 ARG E Protein S 5 FT #SUB 510 510 ARG F 470 470 ARG E Protein S 3 FT #SUB 510 510 ARG F 472 472 LEU E Protein S 1 FT #SUB 510 510 ARG F 494 494 GLN E Protein A 8 FT #SUB 511 511 SER F 469 469 ARG E Protein S 3 FT #SUB 544 544 ILE F 353 353 PHE E Protein S 2 FT #SUB 546 546 PHE F 354 354 GLY E Protein S 1 FT #SUB 546 546 PHE F 355 355 CYS E Protein S 1 FT #SUB 546 546 PHE F 508 508 TYR E Protein S 2 FT #SUB 546 546 PHE F 547 547 MET E Protein S 1 FT #SUB 548 548 GLY F 494 494 GLN E Protein B 1 FT #SUB 549 549 ASN F 469 469 ARG E Protein S 5 FT #SUB 549 549 ASN F 496 496 TYR E Protein S 2 FT #SUB 551 551 HIS F 469 469 ARG E Protein S 5 FT #SUB 553 553 TYR F 469 469 ARG E Protein S 3 FT #HET 8 8 VAL F 22 702 04J F A 3 FT #HET 9 9 VAL F 22 702 04J F B 5 FT #HET 9 9 VAL F 23 703 NDP F B 2 FT #HET 10 10 ALA F 22 702 04J F A 3 FT #HET 10 10 ALA F 23 703 NDP F A 8 FT #HET 17 17 ILE F 23 703 NDP F A 12 FT #HET 18 18 GLY F 23 703 NDP F B 3 FT #HET 19 19 ILE F 23 703 NDP F B 1 FT #HET 21 21 ASN F 23 703 NDP F A 8 FT #HET 22 22 GLY F 23 703 NDP F B 8 FT #HET 23 23 LEU F 23 703 NDP F S 2 FT #HET 25 25 TRP F 23 703 NDP F S 2 FT #HET 31 31 ASP F 22 702 04J F S 5 FT #HET 32 32 PHE F 22 702 04J F A 11 FT #HET 33 33 LYS F 22 702 04J F B 1 FT #HET 35 35 PHE F 22 702 04J F S 9 FT #HET 36 36 SER F 22 702 04J F A 7 FT #HET 80 80 GLY F 23 703 NDP F B 8 FT #HET 81 81 ARG F 23 703 NDP F A 15 FT #HET 82 82 LYS F 23 703 NDP F A 9 FT #HET 83 83 THR F 23 703 NDP F A 9 FT #HET 86 86 SER F 23 703 NDP F S 4 FT #HET 87 87 MET F 22 702 04J F S 1 FT #HET 91 91 PHE F 22 702 04J F S 7 FT #HET 94 94 LEU F 22 702 04J F S 1 FT #HET 97 97 ARG F 22 702 04J F S 5 FT #HET 102 102 VAL F 23 703 NDP F A 8 FT #HET 103 103 SER F 23 703 NDP F A 7 FT #HET 104 104 SER F 23 703 NDP F A 4 FT #HET 105 105 SER F 23 703 NDP F A 3 FT #HET 128 128 ALA F 23 703 NDP F B 1 FT #HET 151 151 VAL F 22 702 04J F S 1 FT #HET 153 153 GLY F 23 703 NDP F B 6 FT #HET 154 154 ALA F 23 703 NDP F A 10 FT #HET 155 155 GLY F 23 703 NDP F B 3 FT #HET 156 156 LEU F 23 703 NDP F B 1 FT #HET 157 157 TYR F 23 703 NDP F S 1 FT #HET 182 182 VAL F 23 703 NDP F S 3 FT #HET 381 381 GLU F 24 704 1UE F S 1 FT #HET 402 402 ILE F 24 704 1UE F B 2 FT #HET 403 403 TRP F 24 704 1UE F S 7 FT #HET 406 406 ASN F 24 704 1UE F S 3 FT #HET 429 429 TYR F 21 701 UMP F S 2 FT #HET 469 469 ARG F 17 701 UMP E S 11 FT #HET 470 470 ARG F 17 701 UMP E S 6 FT #HET 489 489 CYS F 21 701 UMP F S 14 FT #HET 490 490 HIS F 21 701 UMP F S 2 FT #HET 509 509 GLN F 21 701 UMP F S 3 FT #HET 510 510 ARG F 21 701 UMP F S 7 FT #HET 511 511 SER F 21 701 UMP F A 10 FT #HET 512 512 CYS F 21 701 UMP F B 4 FT #HET 513 513 ASP F 21 701 UMP F A 6 FT #HET 513 513 ASP F 24 704 1UE F S 4 FT #HET 516 516 LEU F 24 704 1UE F S 5 FT #HET 517 517 GLY F 24 704 1UE F B 2 FT #HET 520 520 PHE F 24 704 1UE F S 4 FT #HET 521 521 ASN F 21 701 UMP F S 5 FT #HET 551 551 HIS F 21 701 UMP F S 6 FT #HET 553 553 TYR F 21 701 UMP F S 3 FT #HET 553 553 TYR F 24 704 1UE F S 1 FT #HET 608 608 MET F 24 704 1UE F S 4 FT #HET 609 609 ALA F 24 704 1UE F B 1 FT DISORDER 1 2 FT DISORDER 42 73 FT DISORDER 108 125 FT DISORDER 152 152 FT DISORDER 197 223 FT DISORDER 252 284 FT DISORDER 302 307 CC SEQUENCE 491 AA (ATOM); CC KPVCLVVAMT PKRGIGINNG LPWPHLTTDF KHFSRVTKTF NAVVMGRKTW ESMPRKFRPL CC VDRLNIVVSS SLKVCASLPA ALSLLEEEYK DSVDQIFVVG AGLYEAALSL GVASHLYITR CC VAREFPCDVF FPAFPGDDIL SNKEATYRPI FISKTFSDNG VPYDFVVLEK RSSAAAIAPV CC LAWMDEEDKE LIRAVPHVHF RGHEEFQYLD LIADIINNGR TMDDRTGVGV ISKFGCTMRY CC SLDQAFPLLT TKRVFWKGVL EELLWFIRGD TNANHLSEKG VKIWDKNVTR EFLDSRNLPH CC REVGDIGPGY GFQWRHFGAA YKDMHTDYTG QGVDQLKNVI QMLRTNPTDR RMLMTAWNPA CC ALDEMALPPC HLLCQFYVND QKELSCIMYQ RSCDVGLGVP FNIASYSLLT LMVAHVCNLK CC PKEFIHFMGN THVYTNHVEA LKEQLRREPR PFPIVNILNK ERIKEIDDFT AEDFEVVGYV CC PHGRIQMEMA V CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLN CC ATOM --KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKT--------- CC *************************************** CC SEQRES GWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNI CC ATOM -----------------------FNAVVMGRKTWESMPRKFRPLVDRLNI CC *************************** CC SEQRES VVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFV CC ATOM VVSSSLK------------------VCASLPAALSLLEEEYKDSVDQIFV CC ******* ************************* CC SEQRES VGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAA CC ATOM V-GAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNK---- CC * ******************************************** CC SEQRES QAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEK CC ATOM -----------------------EATYRPIFISKTFSDNGVPYDFVVLEK CC *************************** CC SEQRES RRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEE CC ATOM R---------------------------------SSAAAIAPVLAWMDEE CC * **************** CC SEQRES DRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVI CC ATOM D------KELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVI CC * ******************************************* CC SEQRES SKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGV CC ATOM SKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGV CC ************************************************** CC SEQRES KIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQ CC ATOM KIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQ CC ************************************************** CC SEQRES GVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQ CC ATOM GVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQ CC ************************************************** CC SEQRES KELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNT CC ATOM KELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNT CC ************************************************** CC SEQRES HVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP CC ATOM HVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP CC ************************************************** CC SEQRES HGRIQMEMAV CC ATOM HGRIQMEMAV CC ********** SQ SEQUENCE 610 AA; MW; CN; MQKPVCLVVA MTPKRGIGIN NGLPWPHLTT DFKHFSRVTK TTPEEASRLN GWLPRKFAKT GDSGLPSPSV GKRFNAVVMG RKTWESMPRK FRPLVDRLNI VVSSSLKEED IAAEKPQAEG QQRVRVCASL PAALSLLEEE YKDSVDQIFV VGGAGLYEAA LSLGVASHLY ITRVAREFPC DVFFPAFPGD DILSNKSTAA QAAAPAESVF VPFCPELGRE KDNEATYRPI FISKTFSDNG VPYDFVVLEK RRKTDDAATA EPSNAMSSLT STRETTPVHG LQAPSSAAAI APVLAWMDEE DRKKREQKEL IRAVPHVHFR GHEEFQYLDL IADIINNGRT MDDRTGVGVI SKFGCTMRYS LDQAFPLLTT KRVFWKGVLE ELLWFIRGDT NANHLSEKGV KIWDKNVTRE FLDSRNLPHR EVGDIGPGYG FQWRHFGAAY KDMHTDYTGQ GVDQLKNVIQ MLRTNPTDRR MLMTAWNPAA LDEMALPPCH LLCQFYVNDQ KELSCIMYQR SCDVGLGVPF NIASYSLLTL MVAHVCNLKP KEFIHFMGNT HVYTNHVEAL KEQLRREPRP FPIVNILNKE RIKEIDDFTA EDFEVVGYVP HGRIQMEMAV // ID 4KY4G STANDARD; PRT; 610 AA. DT CONVERTED FROM PDB (SEQRES) 4KY4 DE Bifunctional dihydrofolate reductase-thymidylate synthase OS Toxoplasma gondii CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.790 CC R-Factor 0.222 FT #SUB 30 30 THR G 296 296 TRP H Protein S 2 FT #SUB 34 34 HIS G 296 296 TRP H Protein A 6 FT #SUB 37 37 ARG G 296 296 TRP H Protein S 2 FT #SUB 37 37 ARG G 299 299 GLU H Protein S 5 FT #SUB 170 170 TYR G 289 289 ALA H Protein S 6 FT #SUB 170 170 TYR G 293 293 VAL H Protein S 1 FT #SUB 230 230 ILE G 290 290 ILE H Protein S 1 FT #SUB 231 231 PHE G 290 290 ILE H Protein S 2 FT #SUB 231 231 PHE G 293 293 VAL H Protein S 2 FT #SUB 231 231 PHE G 297 297 MET H Protein S 2 FT #SUB 233 233 SER G 297 297 MET H Protein S 2 FT #SUB 245 245 PHE G 296 296 TRP H Protein S 3 FT #SUB 245 245 PHE G 297 297 MET H Protein S 1 FT #SUB 249 249 GLU G 286 286 SER H Protein S 1 FT #SUB 285 285 SER G 168 168 HIS H Protein A 3 FT #SUB 286 286 SER G 249 249 GLU H Protein B 1 FT #SUB 289 289 ALA G 170 170 TYR H Protein B 3 FT #SUB 290 290 ILE G 230 230 ILE H Protein S 1 FT #SUB 290 290 ILE G 231 231 PHE H Protein S 1 FT #SUB 290 290 ILE G 319 319 PHE H Protein S 4 FT #SUB 293 293 VAL G 34 34 HIS H Protein S 3 FT #SUB 293 293 VAL G 38 38 VAL H Protein S 1 FT #SUB 293 293 VAL G 170 170 TYR H Protein S 2 FT #SUB 293 293 VAL G 231 231 PHE H Protein S 2 FT #SUB 294 294 LEU G 319 319 PHE H Protein S 2 FT #SUB 296 296 TRP G 30 30 THR H Protein S 2 FT #SUB 296 296 TRP G 34 34 HIS H Protein S 9 FT #SUB 296 296 TRP G 37 37 ARG H Protein S 5 FT #SUB 296 296 TRP G 245 245 PHE H Protein S 1 FT #SUB 297 297 MET G 231 231 PHE H Protein S 1 FT #SUB 297 297 MET G 233 233 SER H Protein S 1 FT #SUB 297 297 MET G 245 245 PHE H Protein S 1 FT #SUB 319 319 PHE G 290 290 ILE H Protein S 5 FT #SUB 319 319 PHE G 294 294 LEU H Protein S 2 FT #SUB 339 339 ARG G 499 499 ASP H Protein S 3 FT #SUB 341 341 MET G 467 467 THR H Protein S 1 FT #SUB 341 341 MET G 497 497 VAL H Protein S 1 FT #SUB 341 341 MET G 498 498 ASN H Protein S 3 FT #SUB 341 341 MET G 499 499 ASP H Protein S 1 FT #SUB 342 342 ASP G 467 467 THR H Protein B 3 FT #SUB 343 343 ASP G 469 469 ARG H Protein S 8 FT #SUB 349 349 VAL G 469 469 ARG H Protein S 1 FT #SUB 351 351 SER G 496 496 TYR H Protein A 6 FT #SUB 353 353 PHE G 358 358 ARG H Protein B 1 FT #SUB 353 353 PHE G 494 494 GLN H Protein S 3 FT #SUB 353 353 PHE G 496 496 TYR H Protein S 16 FT #SUB 353 353 PHE G 504 504 SER H Protein S 2 FT #SUB 353 353 PHE G 506 506 ILE H Protein S 7 FT #SUB 353 353 PHE G 544 544 ILE H Protein A 2 FT #SUB 354 354 GLY G 358 358 ARG H Protein B 3 FT #SUB 354 354 GLY G 506 506 ILE H Protein B 2 FT #SUB 354 354 GLY G 546 546 PHE H Protein B 1 FT #SUB 355 355 CYS G 546 546 PHE H Protein B 1 FT #SUB 356 356 THR G 356 356 THR H Protein S 1 FT #SUB 358 358 ARG G 353 353 PHE H Protein S 2 FT #SUB 358 358 ARG G 354 354 GLY H Protein S 4 FT #SUB 415 415 ARG G 470 470 ARG H Protein S 1 FT #SUB 436 436 PHE G 477 477 ASN H Protein S 1 FT #SUB 436 436 PHE G 478 478 PRO H Protein S 6 FT #SUB 452 452 VAL G 479 479 ALA H Protein S 2 FT #SUB 454 454 GLN G 478 478 PRO H Protein S 2 FT #SUB 467 467 THR G 341 341 MET H Protein S 1 FT #SUB 467 467 THR G 342 342 ASP H Protein S 3 FT #SUB 469 469 ARG G 343 343 ASP H Protein S 3 FT #SUB 469 469 ARG G 349 349 VAL H Protein S 1 FT #SUB 469 469 ARG G 510 510 ARG H Protein A 4 FT #SUB 469 469 ARG G 511 511 SER H Protein S 3 FT #SUB 469 469 ARG G 549 549 ASN H Protein S 5 FT #SUB 469 469 ARG G 551 551 HIS H Protein S 8 FT #SUB 469 469 ARG G 553 553 TYR H Protein S 3 FT #SUB 470 470 ARG G 415 415 ARG H Protein S 1 FT #SUB 470 470 ARG G 476 476 TRP H Protein S 1 FT #SUB 470 470 ARG G 486 486 LEU H Protein S 1 FT #SUB 470 470 ARG G 487 487 PRO H Protein S 5 FT #SUB 470 470 ARG G 510 510 ARG H Protein S 2 FT #SUB 472 472 LEU G 491 491 LEU H Protein S 1 FT #SUB 474 474 THR G 476 476 TRP H Protein S 1 FT #SUB 476 476 TRP G 472 472 LEU H Protein S 1 FT #SUB 476 476 TRP G 474 474 THR H Protein S 1 FT #SUB 477 477 ASN G 436 436 PHE H Protein S 1 FT #SUB 478 478 PRO G 436 436 PHE H Protein S 2 FT #SUB 478 478 PRO G 452 452 VAL H Protein B 2 FT #SUB 478 478 PRO G 454 454 GLN H Protein S 2 FT #SUB 478 478 PRO G 474 474 THR H Protein S 1 FT #SUB 479 479 ALA G 452 452 VAL H Protein B 1 FT #SUB 486 486 LEU G 470 470 ARG H Protein S 1 FT #SUB 487 487 PRO G 470 470 ARG H Protein S 6 FT #SUB 491 491 LEU G 472 472 LEU H Protein S 1 FT #SUB 491 491 LEU G 492 492 LEU H Protein S 1 FT #SUB 492 492 LEU G 491 491 LEU H Protein S 1 FT #SUB 492 492 LEU G 508 508 TYR H Protein S 3 FT #SUB 494 494 GLN G 353 353 PHE H Protein A 5 FT #SUB 494 494 GLN G 508 508 TYR H Protein S 5 FT #SUB 494 494 GLN G 510 510 ARG H Protein S 8 FT #SUB 494 494 GLN G 548 548 GLY H Protein S 1 FT #SUB 494 494 GLN G 549 549 ASN H Protein S 1 FT #SUB 496 496 TYR G 351 351 SER H Protein S 6 FT #SUB 496 496 TYR G 353 353 PHE H Protein S 16 FT #SUB 496 496 TYR G 549 549 ASN H Protein S 2 FT #SUB 497 497 VAL G 341 341 MET H Protein B 1 FT #SUB 499 499 ASP G 339 339 ARG H Protein S 3 FT #SUB 499 499 ASP G 341 341 MET H Protein A 2 FT #SUB 504 504 SER G 353 353 PHE H Protein S 1 FT #SUB 506 506 ILE G 353 353 PHE H Protein A 6 FT #SUB 506 506 ILE G 354 354 GLY H Protein S 2 FT #SUB 506 506 ILE G 508 508 TYR H Protein S 2 FT #SUB 506 506 ILE G 548 548 GLY H Protein S 1 FT #SUB 508 508 TYR G 492 492 LEU H Protein S 1 FT #SUB 508 508 TYR G 494 494 GLN H Protein S 5 FT #SUB 508 508 TYR G 506 506 ILE H Protein S 3 FT #SUB 508 508 TYR G 546 546 PHE H Protein S 3 FT #SUB 510 510 ARG G 469 469 ARG H Protein S 6 FT #SUB 510 510 ARG G 470 470 ARG H Protein S 2 FT #SUB 510 510 ARG G 472 472 LEU H Protein S 2 FT #SUB 510 510 ARG G 494 494 GLN H Protein A 9 FT #SUB 511 511 SER G 469 469 ARG H Protein S 3 FT #SUB 544 544 ILE G 353 353 PHE H Protein S 1 FT #SUB 546 546 PHE G 508 508 TYR H Protein S 2 FT #SUB 546 546 PHE G 546 546 PHE H Protein S 6 FT #SUB 548 548 GLY G 494 494 GLN H Protein B 1 FT #SUB 549 549 ASN G 469 469 ARG H Protein S 4 FT #SUB 549 549 ASN G 496 496 TYR H Protein S 2 FT #SUB 551 551 HIS G 469 469 ARG H Protein S 5 FT #SUB 553 553 TYR G 469 469 ARG H Protein S 3 FT #HET 8 8 VAL G 26 702 04J G A 3 FT #HET 9 9 VAL G 26 702 04J G B 5 FT #HET 9 9 VAL G 27 703 NDP G A 4 FT #HET 10 10 ALA G 26 702 04J G A 3 FT #HET 10 10 ALA G 27 703 NDP G B 8 FT #HET 17 17 ILE G 27 703 NDP G A 12 FT #HET 18 18 GLY G 27 703 NDP G B 2 FT #HET 19 19 ILE G 27 703 NDP G B 1 FT #HET 21 21 ASN G 27 703 NDP G B 7 FT #HET 22 22 GLY G 27 703 NDP G B 7 FT #HET 23 23 LEU G 27 703 NDP G S 3 FT #HET 25 25 TRP G 27 703 NDP G S 1 FT #HET 31 31 ASP G 26 702 04J G S 5 FT #HET 32 32 PHE G 26 702 04J G A 17 FT #HET 33 33 LYS G 26 702 04J G B 2 FT #HET 35 35 PHE G 26 702 04J G S 9 FT #HET 36 36 SER G 26 702 04J G A 7 FT #HET 80 80 GLY G 27 703 NDP G B 7 FT #HET 81 81 ARG G 27 703 NDP G A 16 FT #HET 82 82 LYS G 27 703 NDP G A 11 FT #HET 83 83 THR G 27 703 NDP G A 9 FT #HET 86 86 SER G 27 703 NDP G S 4 FT #HET 87 87 MET G 26 702 04J G S 2 FT #HET 91 91 PHE G 26 702 04J G S 6 FT #HET 94 94 LEU G 26 702 04J G S 5 FT #HET 97 97 ARG G 26 702 04J G S 9 FT #HET 102 102 VAL G 27 703 NDP G A 6 FT #HET 103 103 SER G 27 703 NDP G A 8 FT #HET 104 104 SER G 27 703 NDP G B 3 FT #HET 105 105 SER G 27 703 NDP G A 3 FT #HET 128 128 ALA G 27 703 NDP G B 1 FT #HET 153 153 GLY G 27 703 NDP G B 8 FT #HET 154 154 ALA G 27 703 NDP G A 10 FT #HET 155 155 GLY G 27 703 NDP G B 4 FT #HET 157 157 TYR G 27 703 NDP G S 2 FT #HET 182 182 VAL G 27 703 NDP G S 3 FT #HET 381 381 GLU G 28 704 1UE G S 1 FT #HET 402 402 ILE G 28 704 1UE G A 3 FT #HET 403 403 TRP G 28 704 1UE G S 15 FT #HET 406 406 ASN G 28 704 1UE G S 3 FT #HET 429 429 TYR G 25 701 UMP G S 1 FT #HET 469 469 ARG G 29 701 UMP H S 12 FT #HET 470 470 ARG G 29 701 UMP H S 5 FT #HET 486 486 LEU G 25 701 UMP G S 1 FT #HET 489 489 CYS G 25 701 UMP G S 16 FT #HET 490 490 HIS G 25 701 UMP G S 3 FT #HET 509 509 GLN G 25 701 UMP G S 3 FT #HET 510 510 ARG G 25 701 UMP G S 5 FT #HET 511 511 SER G 25 701 UMP G A 10 FT #HET 512 512 CYS G 25 701 UMP G B 1 FT #HET 513 513 ASP G 25 701 UMP G A 4 FT #HET 513 513 ASP G 28 704 1UE G S 4 FT #HET 516 516 LEU G 28 704 1UE G S 5 FT #HET 517 517 GLY G 28 704 1UE G B 2 FT #HET 520 520 PHE G 28 704 1UE G S 2 FT #HET 521 521 ASN G 25 701 UMP G S 10 FT #HET 551 551 HIS G 25 701 UMP G S 2 FT #HET 553 553 TYR G 25 701 UMP G S 1 FT #HET 553 553 TYR G 28 704 1UE G S 2 FT #HET 608 608 MET G 28 704 1UE G S 4 FT #HET 609 609 ALA G 28 704 1UE G B 1 FT DISORDER 1 2 FT DISORDER 42 73 FT DISORDER 108 125 FT DISORDER 152 152 FT DISORDER 197 223 FT DISORDER 252 284 FT DISORDER 300 307 CC SEQUENCE 489 AA (ATOM); CC KPVCLVVAMT PKRGIGINNG LPWPHLTTDF KHFSRVTKTF NAVVMGRKTW ESMPRKFRPL CC VDRLNIVVSS SLKVCASLPA ALSLLEEEYK DSVDQIFVVG AGLYEAALSL GVASHLYITR CC VAREFPCDVF FPAFPGDDIL SNKEATYRPI FISKTFSDNG VPYDFVVLEK RSSAAAIAPV CC LAWMDEKELI RAVPHVHFRG HEEFQYLDLI ADIINNGRTM DDRTGVGVIS KFGCTMRYSL CC DQAFPLLTTK RVFWKGVLEE LLWFIRGDTN ANHLSEKGVK IWDKNVTREF LDSRNLPHRE CC VGDIGPGYGF QWRHFGAAYK DMHTDYTGQG VDQLKNVIQM LRTNPTDRRM LMTAWNPAAL CC DEMALPPCHL LCQFYVNDQK ELSCIMYQRS CDVGLGVPFN IASYSLLTLM VAHVCNLKPK CC EFIHFMGNTH VYTNHVEALK EQLRREPRPF PIVNILNKER IKEIDDFTAE DFEVVGYVPH CC GRIQMEMAV CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLN CC ATOM --KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKT--------- CC *************************************** CC SEQRES GWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNI CC ATOM -----------------------FNAVVMGRKTWESMPRKFRPLVDRLNI CC *************************** CC SEQRES VVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFV CC ATOM VVSSSLK------------------VCASLPAALSLLEEEYKDSVDQIFV CC ******* ************************* CC SEQRES VGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAA CC ATOM V-GAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNK---- CC * ******************************************** CC SEQRES QAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEK CC ATOM -----------------------EATYRPIFISKTFSDNGVPYDFVVLEK CC *************************** CC SEQRES RRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEE CC ATOM R---------------------------------SSAAAIAPVLAWMDE- CC * *************** CC SEQRES DRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVI CC ATOM -------KELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVI CC ******************************************* CC SEQRES SKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGV CC ATOM SKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGV CC ************************************************** CC SEQRES KIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQ CC ATOM KIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQ CC ************************************************** CC SEQRES GVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQ CC ATOM GVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQ CC ************************************************** CC SEQRES KELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNT CC ATOM KELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNT CC ************************************************** CC SEQRES HVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP CC ATOM HVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP CC ************************************************** CC SEQRES HGRIQMEMAV CC ATOM HGRIQMEMAV CC ********** SQ SEQUENCE 610 AA; MW; CN; MQKPVCLVVA MTPKRGIGIN NGLPWPHLTT DFKHFSRVTK TTPEEASRLN GWLPRKFAKT GDSGLPSPSV GKRFNAVVMG RKTWESMPRK FRPLVDRLNI VVSSSLKEED IAAEKPQAEG QQRVRVCASL PAALSLLEEE YKDSVDQIFV VGGAGLYEAA LSLGVASHLY ITRVAREFPC DVFFPAFPGD DILSNKSTAA QAAAPAESVF VPFCPELGRE KDNEATYRPI FISKTFSDNG VPYDFVVLEK RRKTDDAATA EPSNAMSSLT STRETTPVHG LQAPSSAAAI APVLAWMDEE DRKKREQKEL IRAVPHVHFR GHEEFQYLDL IADIINNGRT MDDRTGVGVI SKFGCTMRYS LDQAFPLLTT KRVFWKGVLE ELLWFIRGDT NANHLSEKGV KIWDKNVTRE FLDSRNLPHR EVGDIGPGYG FQWRHFGAAY KDMHTDYTGQ GVDQLKNVIQ MLRTNPTDRR MLMTAWNPAA LDEMALPPCH LLCQFYVNDQ KELSCIMYQR SCDVGLGVPF NIASYSLLTL MVAHVCNLKP KEFIHFMGNT HVYTNHVEAL KEQLRREPRP FPIVNILNKE RIKEIDDFTA EDFEVVGYVP HGRIQMEMAV // ID 4KY4H STANDARD; PRT; 610 AA. DT CONVERTED FROM PDB (SEQRES) 4KY4 DE Bifunctional dihydrofolate reductase-thymidylate synthase OS Toxoplasma gondii CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.790 CC R-Factor 0.222 FT #SUB 30 30 THR H 296 296 TRP G Protein S 2 FT #SUB 34 34 HIS H 293 293 VAL G Protein S 3 FT #SUB 34 34 HIS H 296 296 TRP G Protein A 9 FT #SUB 37 37 ARG H 296 296 TRP G Protein S 5 FT #SUB 38 38 VAL H 293 293 VAL G Protein S 1 FT #SUB 168 168 HIS H 285 285 SER G Protein S 3 FT #SUB 170 170 TYR H 289 289 ALA G Protein S 3 FT #SUB 170 170 TYR H 293 293 VAL G Protein S 2 FT #SUB 230 230 ILE H 290 290 ILE G Protein S 1 FT #SUB 231 231 PHE H 290 290 ILE G Protein S 1 FT #SUB 231 231 PHE H 293 293 VAL G Protein S 2 FT #SUB 231 231 PHE H 297 297 MET G Protein S 1 FT #SUB 233 233 SER H 297 297 MET G Protein S 1 FT #SUB 245 245 PHE H 296 296 TRP G Protein S 1 FT #SUB 245 245 PHE H 297 297 MET G Protein S 1 FT #SUB 249 249 GLU H 286 286 SER G Protein S 1 FT #SUB 286 286 SER H 249 249 GLU G Protein S 1 FT #SUB 289 289 ALA H 170 170 TYR G Protein A 6 FT #SUB 290 290 ILE H 230 230 ILE G Protein S 1 FT #SUB 290 290 ILE H 231 231 PHE G Protein S 2 FT #SUB 290 290 ILE H 319 319 PHE G Protein S 5 FT #SUB 293 293 VAL H 170 170 TYR G Protein S 1 FT #SUB 293 293 VAL H 231 231 PHE G Protein S 2 FT #SUB 294 294 LEU H 319 319 PHE G Protein S 2 FT #SUB 296 296 TRP H 30 30 THR G Protein S 2 FT #SUB 296 296 TRP H 34 34 HIS G Protein S 6 FT #SUB 296 296 TRP H 37 37 ARG G Protein S 2 FT #SUB 296 296 TRP H 245 245 PHE G Protein S 3 FT #SUB 297 297 MET H 231 231 PHE G Protein S 2 FT #SUB 297 297 MET H 233 233 SER G Protein S 2 FT #SUB 297 297 MET H 245 245 PHE G Protein S 1 FT #SUB 299 299 GLU H 37 37 ARG G Protein S 5 FT #SUB 319 319 PHE H 290 290 ILE G Protein S 4 FT #SUB 319 319 PHE H 294 294 LEU G Protein S 2 FT #SUB 339 339 ARG H 499 499 ASP G Protein S 3 FT #SUB 341 341 MET H 467 467 THR G Protein S 1 FT #SUB 341 341 MET H 497 497 VAL G Protein S 1 FT #SUB 341 341 MET H 499 499 ASP G Protein S 2 FT #SUB 342 342 ASP H 467 467 THR G Protein B 3 FT #SUB 343 343 ASP H 469 469 ARG G Protein S 3 FT #SUB 349 349 VAL H 469 469 ARG G Protein S 1 FT #SUB 351 351 SER H 496 496 TYR G Protein A 6 FT #SUB 353 353 PHE H 358 358 ARG G Protein B 2 FT #SUB 353 353 PHE H 494 494 GLN G Protein S 5 FT #SUB 353 353 PHE H 496 496 TYR G Protein S 16 FT #SUB 353 353 PHE H 504 504 SER G Protein S 1 FT #SUB 353 353 PHE H 506 506 ILE G Protein S 6 FT #SUB 353 353 PHE H 544 544 ILE G Protein B 1 FT #SUB 354 354 GLY H 358 358 ARG G Protein B 4 FT #SUB 354 354 GLY H 506 506 ILE G Protein B 2 FT #SUB 356 356 THR H 356 356 THR G Protein S 1 FT #SUB 358 358 ARG H 353 353 PHE G Protein S 1 FT #SUB 358 358 ARG H 354 354 GLY G Protein S 3 FT #SUB 415 415 ARG H 470 470 ARG G Protein S 1 FT #SUB 436 436 PHE H 477 477 ASN G Protein S 1 FT #SUB 436 436 PHE H 478 478 PRO G Protein S 2 FT #SUB 452 452 VAL H 478 478 PRO G Protein S 2 FT #SUB 452 452 VAL H 479 479 ALA G Protein S 1 FT #SUB 454 454 GLN H 478 478 PRO G Protein S 2 FT #SUB 467 467 THR H 341 341 MET G Protein S 1 FT #SUB 467 467 THR H 342 342 ASP G Protein S 3 FT #SUB 469 469 ARG H 343 343 ASP G Protein S 8 FT #SUB 469 469 ARG H 349 349 VAL G Protein S 1 FT #SUB 469 469 ARG H 510 510 ARG G Protein A 6 FT #SUB 469 469 ARG H 511 511 SER G Protein S 3 FT #SUB 469 469 ARG H 549 549 ASN G Protein S 4 FT #SUB 469 469 ARG H 551 551 HIS G Protein S 5 FT #SUB 469 469 ARG H 553 553 TYR G Protein S 3 FT #SUB 470 470 ARG H 415 415 ARG G Protein S 1 FT #SUB 470 470 ARG H 486 486 LEU G Protein S 1 FT #SUB 470 470 ARG H 487 487 PRO G Protein S 6 FT #SUB 470 470 ARG H 510 510 ARG G Protein S 2 FT #SUB 472 472 LEU H 476 476 TRP G Protein S 1 FT #SUB 472 472 LEU H 491 491 LEU G Protein S 1 FT #SUB 472 472 LEU H 510 510 ARG G Protein S 2 FT #SUB 474 474 THR H 476 476 TRP G Protein S 1 FT #SUB 474 474 THR H 478 478 PRO G Protein S 1 FT #SUB 476 476 TRP H 470 470 ARG G Protein S 1 FT #SUB 476 476 TRP H 474 474 THR G Protein S 1 FT #SUB 477 477 ASN H 436 436 PHE G Protein S 1 FT #SUB 478 478 PRO H 436 436 PHE G Protein S 6 FT #SUB 478 478 PRO H 454 454 GLN G Protein S 2 FT #SUB 479 479 ALA H 452 452 VAL G Protein B 2 FT #SUB 486 486 LEU H 470 470 ARG G Protein S 1 FT #SUB 487 487 PRO H 470 470 ARG G Protein S 5 FT #SUB 491 491 LEU H 472 472 LEU G Protein S 1 FT #SUB 491 491 LEU H 492 492 LEU G Protein S 1 FT #SUB 492 492 LEU H 491 491 LEU G Protein S 1 FT #SUB 492 492 LEU H 508 508 TYR G Protein S 1 FT #SUB 494 494 GLN H 353 353 PHE G Protein B 3 FT #SUB 494 494 GLN H 508 508 TYR G Protein S 5 FT #SUB 494 494 GLN H 510 510 ARG G Protein S 9 FT #SUB 494 494 GLN H 548 548 GLY G Protein S 1 FT #SUB 496 496 TYR H 351 351 SER G Protein S 6 FT #SUB 496 496 TYR H 353 353 PHE G Protein S 16 FT #SUB 496 496 TYR H 549 549 ASN G Protein S 2 FT #SUB 497 497 VAL H 341 341 MET G Protein B 1 FT #SUB 498 498 ASN H 341 341 MET G Protein B 3 FT #SUB 499 499 ASP H 339 339 ARG G Protein S 3 FT #SUB 499 499 ASP H 341 341 MET G Protein B 1 FT #SUB 504 504 SER H 353 353 PHE G Protein A 2 FT #SUB 506 506 ILE H 353 353 PHE G Protein A 7 FT #SUB 506 506 ILE H 354 354 GLY G Protein S 2 FT #SUB 506 506 ILE H 508 508 TYR G Protein S 3 FT #SUB 508 508 TYR H 492 492 LEU G Protein S 3 FT #SUB 508 508 TYR H 494 494 GLN G Protein S 5 FT #SUB 508 508 TYR H 506 506 ILE G Protein S 2 FT #SUB 508 508 TYR H 546 546 PHE G Protein S 2 FT #SUB 510 510 ARG H 469 469 ARG G Protein S 4 FT #SUB 510 510 ARG H 470 470 ARG G Protein S 2 FT #SUB 510 510 ARG H 494 494 GLN G Protein A 8 FT #SUB 511 511 SER H 469 469 ARG G Protein S 3 FT #SUB 544 544 ILE H 353 353 PHE G Protein S 2 FT #SUB 546 546 PHE H 354 354 GLY G Protein S 1 FT #SUB 546 546 PHE H 355 355 CYS G Protein S 1 FT #SUB 546 546 PHE H 508 508 TYR G Protein S 3 FT #SUB 546 546 PHE H 546 546 PHE G Protein S 6 FT #SUB 548 548 GLY H 494 494 GLN G Protein B 1 FT #SUB 548 548 GLY H 506 506 ILE G Protein B 1 FT #SUB 549 549 ASN H 469 469 ARG G Protein S 5 FT #SUB 549 549 ASN H 494 494 GLN G Protein B 1 FT #SUB 549 549 ASN H 496 496 TYR G Protein S 2 FT #SUB 551 551 HIS H 469 469 ARG G Protein S 8 FT #SUB 553 553 TYR H 469 469 ARG G Protein S 3 FT #HET 8 8 VAL H 30 702 04J H A 6 FT #HET 9 9 VAL H 30 702 04J H B 8 FT #HET 9 9 VAL H 31 703 NDP H A 3 FT #HET 10 10 ALA H 30 702 04J H A 6 FT #HET 10 10 ALA H 31 703 NDP H B 7 FT #HET 17 17 ILE H 31 703 NDP H B 7 FT #HET 18 18 GLY H 31 703 NDP H B 2 FT #HET 19 19 ILE H 31 703 NDP H B 1 FT #HET 21 21 ASN H 31 703 NDP H A 8 FT #HET 22 22 GLY H 31 703 NDP H B 13 FT #HET 23 23 LEU H 31 703 NDP H A 2 FT #HET 25 25 TRP H 30 702 04J H S 1 FT #HET 25 25 TRP H 31 703 NDP H S 1 FT #HET 31 31 ASP H 30 702 04J H S 10 FT #HET 32 32 PHE H 30 702 04J H S 15 FT #HET 35 35 PHE H 30 702 04J H S 8 FT #HET 36 36 SER H 30 702 04J H S 5 FT #HET 80 80 GLY H 31 703 NDP H B 6 FT #HET 81 81 ARG H 31 703 NDP H A 26 FT #HET 82 82 LYS H 31 703 NDP H A 5 FT #HET 83 83 THR H 31 703 NDP H A 8 FT #HET 86 86 SER H 31 703 NDP H S 3 FT #HET 87 87 MET H 30 702 04J H S 2 FT #HET 91 91 PHE H 30 702 04J H S 9 FT #HET 94 94 LEU H 30 702 04J H S 2 FT #HET 97 97 ARG H 30 702 04J H S 5 FT #HET 102 102 VAL H 31 703 NDP H B 9 FT #HET 103 103 SER H 31 703 NDP H A 9 FT #HET 104 104 SER H 31 703 NDP H A 5 FT #HET 105 105 SER H 31 703 NDP H A 2 FT #HET 153 153 GLY H 31 703 NDP H B 9 FT #HET 154 154 ALA H 31 703 NDP H A 9 FT #HET 155 155 GLY H 31 703 NDP H B 2 FT #HET 156 156 LEU H 31 703 NDP H A 2 FT #HET 157 157 TYR H 31 703 NDP H S 1 FT #HET 172 172 THR H 30 702 04J H S 2 FT #HET 182 182 VAL H 31 703 NDP H S 2 FT #HET 381 381 GLU H 32 704 1UE H S 2 FT #HET 402 402 ILE H 32 704 1UE H A 6 FT #HET 403 403 TRP H 32 704 1UE H S 7 FT #HET 406 406 ASN H 32 704 1UE H S 1 FT #HET 429 429 TYR H 29 701 UMP H S 1 FT #HET 469 469 ARG H 25 701 UMP G S 13 FT #HET 470 470 ARG H 25 701 UMP G S 3 FT #HET 489 489 CYS H 29 701 UMP H S 11 FT #HET 490 490 HIS H 29 701 UMP H S 3 FT #HET 509 509 GLN H 29 701 UMP H S 3 FT #HET 510 510 ARG H 29 701 UMP H S 8 FT #HET 511 511 SER H 29 701 UMP H A 12 FT #HET 512 512 CYS H 29 701 UMP H B 2 FT #HET 513 513 ASP H 29 701 UMP H A 4 FT #HET 513 513 ASP H 32 704 1UE H S 5 FT #HET 516 516 LEU H 32 704 1UE H A 13 FT #HET 517 517 GLY H 29 701 UMP H B 1 FT #HET 517 517 GLY H 32 704 1UE H B 4 FT #HET 521 521 ASN H 29 701 UMP H S 9 FT #HET 551 551 HIS H 29 701 UMP H S 6 FT #HET 553 553 TYR H 29 701 UMP H S 3 FT #HET 553 553 TYR H 32 704 1UE H S 1 FT #HET 608 608 MET H 32 704 1UE H S 6 FT #HET 609 609 ALA H 32 704 1UE H B 1 FT DISORDER 1 2 FT DISORDER 42 73 FT DISORDER 108 125 FT DISORDER 152 152 FT DISORDER 197 223 FT DISORDER 252 284 FT DISORDER 302 307 CC SEQUENCE 491 AA (ATOM); CC KPVCLVVAMT PKRGIGINNG LPWPHLTTDF KHFSRVTKTF NAVVMGRKTW ESMPRKFRPL CC VDRLNIVVSS SLKVCASLPA ALSLLEEEYK DSVDQIFVVG AGLYEAALSL GVASHLYITR CC VAREFPCDVF FPAFPGDDIL SNKEATYRPI FISKTFSDNG VPYDFVVLEK RSSAAAIAPV CC LAWMDEEDKE LIRAVPHVHF RGHEEFQYLD LIADIINNGR TMDDRTGVGV ISKFGCTMRY CC SLDQAFPLLT TKRVFWKGVL EELLWFIRGD TNANHLSEKG VKIWDKNVTR EFLDSRNLPH CC REVGDIGPGY GFQWRHFGAA YKDMHTDYTG QGVDQLKNVI QMLRTNPTDR RMLMTAWNPA CC ALDEMALPPC HLLCQFYVND QKELSCIMYQ RSCDVGLGVP FNIASYSLLT LMVAHVCNLK CC PKEFIHFMGN THVYTNHVEA LKEQLRREPR PFPIVNILNK ERIKEIDDFT AEDFEVVGYV CC PHGRIQMEMA V CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLN CC ATOM --KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKT--------- CC *************************************** CC SEQRES GWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNI CC ATOM -----------------------FNAVVMGRKTWESMPRKFRPLVDRLNI CC *************************** CC SEQRES VVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFV CC ATOM VVSSSLK------------------VCASLPAALSLLEEEYKDSVDQIFV CC ******* ************************* CC SEQRES VGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAA CC ATOM V-GAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNK---- CC * ******************************************** CC SEQRES QAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEK CC ATOM -----------------------EATYRPIFISKTFSDNGVPYDFVVLEK CC *************************** CC SEQRES RRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEE CC ATOM R---------------------------------SSAAAIAPVLAWMDEE CC * **************** CC SEQRES DRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVI CC ATOM D------KELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVI CC * ******************************************* CC SEQRES SKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGV CC ATOM SKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGV CC ************************************************** CC SEQRES KIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQ CC ATOM KIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQ CC ************************************************** CC SEQRES GVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQ CC ATOM GVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQ CC ************************************************** CC SEQRES KELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNT CC ATOM KELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNT CC ************************************************** CC SEQRES HVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP CC ATOM HVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP CC ************************************************** CC SEQRES HGRIQMEMAV CC ATOM HGRIQMEMAV CC ********** SQ SEQUENCE 610 AA; MW; CN; MQKPVCLVVA MTPKRGIGIN NGLPWPHLTT DFKHFSRVTK TTPEEASRLN GWLPRKFAKT GDSGLPSPSV GKRFNAVVMG RKTWESMPRK FRPLVDRLNI VVSSSLKEED IAAEKPQAEG QQRVRVCASL PAALSLLEEE YKDSVDQIFV VGGAGLYEAA LSLGVASHLY ITRVAREFPC DVFFPAFPGD DILSNKSTAA QAAAPAESVF VPFCPELGRE KDNEATYRPI FISKTFSDNG VPYDFVVLEK RRKTDDAATA EPSNAMSSLT STRETTPVHG LQAPSSAAAI APVLAWMDEE DRKKREQKEL IRAVPHVHFR GHEEFQYLDL IADIINNGRT MDDRTGVGVI SKFGCTMRYS LDQAFPLLTT KRVFWKGVLE ELLWFIRGDT NANHLSEKGV KIWDKNVTRE FLDSRNLPHR EVGDIGPGYG FQWRHFGAAY KDMHTDYTGQ GVDQLKNVIQ MLRTNPTDRR MLMTAWNPAA LDEMALPPCH LLCQFYVNDQ KELSCIMYQR SCDVGLGVPF NIASYSLLTL MVAHVCNLKP KEFIHFMGNT HVYTNHVEAL KEQLRREPRP FPIVNILNKE RIKEIDDFTA EDFEVVGYVP HGRIQMEMAV //