ID	4KD7A	STANDARD;	PRT;	186	AA.
DT	CONVERTED FROM PDB (SEQRES) 4KD7
DE	Dihydrofolate reductase
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.720
CC	R-Factor	0.177
FT	#SUB	137	 137 	ARG	A	102	 102 	GLN	B	Protein	S	1
FT	#SUB	137	 137 	ARG	A	103	 103 	PRO	B	Protein	S	1
FT	#SUB	137	 137 	ARG	A	104	 104 	GLU	B	Protein	S	4
FT	#SUB	150	 150 	GLU	A	108	 108 	LYS	B	Protein	S	3
FT	#SUB	153	 153 	LEU	A	87	  87 	HIS	B	Protein	B	6
FT	#SUB	153	 153 	LEU	A	88	  88 	PHE	B	Protein	S	1
FT	#SUB	153	 153 	LEU	A	104	 104 	GLU	B	Protein	S	1
FT	#SUB	154	 154 	GLU	A	87	  87 	HIS	B	Protein	B	5
FT	#SUB	156	 156 	TYR	A	87	  87 	HIS	B	Protein	B	5
FT	#SUB	157	 157 	LYS	A	81	  81 	GLU	B	Protein	S	6
FT	#SUB	157	 157 	LYS	A	82	  82 	PRO	B	Protein	S	5
FT	#SUB	157	 157 	LYS	A	86	  86 	ALA	B	Protein	S	2
FT	#SUB	157	 157 	LYS	A	87	  87 	HIS	B	Protein	A	3
FT	#SUB	158	 158 	LEU	A	82	  82 	PRO	B	Protein	B	2
FT	#SUB	158	 158 	LEU	A	87	  87 	HIS	B	Protein	B	3
FT	#SUB	158	 158 	LEU	A	99	  99 	LEU	B	Protein	S	1
FT	#SUB	158	 158 	LEU	A	104	 104 	GLU	B	Protein	S	1
FT	#SUB	159	 159 	LEU	A	80	  80 	LYS	B	Protein	S	1
FT	#SUB	159	 159 	LEU	A	81	  81 	GLU	B	Protein	S	1
FT	#SUB	160	 160 	PRO	A	80	  80 	LYS	B	Protein	S	2
FT	#SUB	160	 160 	PRO	A	89	  89 	LEU	B	Protein	S	3
FT	#SUB	161	 161 	GLU	A	91	  91 	ARG	B	Protein	S	3
FT	#SUB	178	 178 	LYS	A	99	  99 	LEU	B	Protein	S	1
FT	#SUB	178	 178 	LYS	A	102	 102 	GLN	B	Protein	S	5
FT	#SUB	180	 180 	GLU	A	102	 102 	GLN	B	Protein	S	1
FT	#SUB	180	 180 	GLU	A	104	 104 	GLU	B	Protein	S	6
FT	#SUB	182	 182 	TYR	A	104	 104 	GLU	B	Protein	S	5
FT	#HET	7	   7 	ILE	A	2	202 	9DR	A	A	9
FT	#HET	8	   8 	VAL	A	1	201 	NDP	A	A	4
FT	#HET	8	   8 	VAL	A	2	202 	9DR	A	B	9
FT	#HET	9	   9 	ALA	A	1	201 	NDP	A	A	12
FT	#HET	9	   9 	ALA	A	2	202 	9DR	A	A	8
FT	#HET	16	  16 	ILE	A	1	201 	NDP	A	A	9
FT	#HET	17	  17 	GLY	A	1	201 	NDP	A	B	3
FT	#HET	18	  18 	LYS	A	1	201 	NDP	A	B	1
FT	#HET	20	  20 	GLY	A	1	201 	NDP	A	B	3
FT	#HET	21	  21 	ASP	A	1	201 	NDP	A	B	8
FT	#HET	21	  21 	ASP	A	2	202 	9DR	A	S	1
FT	#HET	22	  22 	LEU	A	1	201 	NDP	A	A	4
FT	#HET	24	  24 	TRP	A	1	201 	NDP	A	S	2
FT	#HET	28	  28 	ARG	A	4	204 	SO4	A	S	2
FT	#HET	30	  30 	GLU	A	2	202 	9DR	A	S	12
FT	#HET	31	  31 	PHE	A	2	202 	9DR	A	A	8
FT	#HET	31	  31 	PHE	A	4	204 	SO4	A	S	2
FT	#HET	34	  34 	PHE	A	2	202 	9DR	A	S	9
FT	#HET	35	  35 	GLN	A	2	202 	9DR	A	S	1
FT	#HET	35	  35 	GLN	A	4	204 	SO4	A	S	1
FT	#HET	53	  53 	GLY	A	1	201 	NDP	A	B	8
FT	#HET	54	  54 	LYS	A	1	201 	NDP	A	A	8
FT	#HET	55	  55 	LYS	A	1	201 	NDP	A	A	13
FT	#HET	56	  56 	THR	A	1	201 	NDP	A	A	11
FT	#HET	56	  56 	THR	A	2	202 	9DR	A	S	1
FT	#HET	59	  59 	SER	A	1	201 	NDP	A	S	2
FT	#HET	59	  59 	SER	A	2	202 	9DR	A	A	3
FT	#HET	60	  60 	ILE	A	2	202 	9DR	A	S	3
FT	#HET	61	  61 	PRO	A	2	202 	9DR	A	S	1
FT	#HET	67	  67 	LEU	A	2	202 	9DR	A	S	2
FT	#HET	68	  68 	LYS	A	4	204 	SO4	A	S	4
FT	#HET	75	  75 	LEU	A	1	201 	NDP	A	A	6
FT	#HET	76	  76 	SER	A	1	201 	NDP	A	A	6
FT	#HET	77	  77 	ARG	A	1	201 	NDP	A	A	7
FT	#HET	77	  77 	ARG	A	3	203 	SO4	A	S	9
FT	#HET	78	  78 	GLU	A	1	201 	NDP	A	A	8
FT	#HET	91	  91 	ARG	A	1	201 	NDP	A	B	4
FT	#HET	91	  91 	ARG	A	3	203 	SO4	A	S	6
FT	#HET	92	  92 	SER	A	1	201 	NDP	A	B	2
FT	#HET	115	 115 	VAL	A	1	201 	NDP	A	B	3
FT	#HET	115	 115 	VAL	A	2	202 	9DR	A	A	4
FT	#HET	116	 116 	GLY	A	1	201 	NDP	A	B	3
FT	#HET	117	 117 	GLY	A	1	201 	NDP	A	B	10
FT	#HET	118	 118 	SER	A	1	201 	NDP	A	A	5
FT	#HET	119	 119 	SER	A	1	201 	NDP	A	A	7
FT	#HET	120	 120 	VAL	A	1	201 	NDP	A	A	6
FT	#HET	121	 121 	TYR	A	1	201 	NDP	A	S	2
FT	#HET	121	 121 	TYR	A	2	202 	9DR	A	S	1
FT	#HET	123	 123 	GLU	A	1	201 	NDP	A	S	4
FT	#HET	136	 136 	THR	A	2	202 	9DR	A	S	1
FT	#HET	146	 146 	THR	A	1	201 	NDP	A	S	5
CC	SEQUENCE	186 AA (ATOM);
CC	VGSLNCIVAV SQNMGIGKNG DLPWPPLRNE FRYFQRMTTT SSVEGKQNLV IMGKKTWFSI
CC	PEKNRPLKGR INLVLSRELK EPPQGAHFLS RSLDDALKLT EQPELANKVD MVWIVGGSSV
CC	YKEAMNHPGH LKLFVTRIMQ DFESDTFFPE IDLEKYKLLP EYPGVLSDVQ EEKGIKYKFE
CC	VYEKND
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLV
CC	ATOM   VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLV
CC	       **************************************************
CC	SEQRES IMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLT
CC	ATOM   IMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLT
CC	       **************************************************
CC	SEQRES EQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPE
CC	ATOM   EQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPE
CC	       **************************************************
CC	SEQRES IDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
CC	ATOM   IDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
CC	       ************************************
SQ	SEQUENCE	186 AA;      MW;         CN;
	VGSLNCIVAV SQNMGIGKNG DLPWPPLRNE FRYFQRMTTT SSVEGKQNLV IMGKKTWFSI
	PEKNRPLKGR INLVLSRELK EPPQGAHFLS RSLDDALKLT EQPELANKVD MVWIVGGSSV
	YKEAMNHPGH LKLFVTRIMQ DFESDTFFPE IDLEKYKLLP EYPGVLSDVQ EEKGIKYKFE
	VYEKND
//
ID	4KD7B	STANDARD;	PRT;	186	AA.
DT	CONVERTED FROM PDB (SEQRES) 4KD7
DE	Dihydrofolate reductase
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.720
CC	R-Factor	0.177
FT	#SUB	80	  80 	LYS	B	159	 159 	LEU	A	Protein	B	1
FT	#SUB	80	  80 	LYS	B	160	 160 	PRO	A	Protein	B	2
FT	#SUB	81	  81 	GLU	B	157	 157 	LYS	A	Protein	S	6
FT	#SUB	81	  81 	GLU	B	159	 159 	LEU	A	Protein	S	1
FT	#SUB	82	  82 	PRO	B	157	 157 	LYS	A	Protein	A	5
FT	#SUB	82	  82 	PRO	B	158	 158 	LEU	A	Protein	S	2
FT	#SUB	86	  86 	ALA	B	157	 157 	LYS	A	Protein	B	2
FT	#SUB	87	  87 	HIS	B	153	 153 	LEU	A	Protein	S	6
FT	#SUB	87	  87 	HIS	B	154	 154 	GLU	A	Protein	S	5
FT	#SUB	87	  87 	HIS	B	156	 156 	TYR	A	Protein	S	5
FT	#SUB	87	  87 	HIS	B	157	 157 	LYS	A	Protein	A	3
FT	#SUB	87	  87 	HIS	B	158	 158 	LEU	A	Protein	B	3
FT	#SUB	88	  88 	PHE	B	153	 153 	LEU	A	Protein	S	1
FT	#SUB	89	  89 	LEU	B	160	 160 	PRO	A	Protein	A	3
FT	#SUB	91	  91 	ARG	B	161	 161 	GLU	A	Protein	S	3
FT	#SUB	99	  99 	LEU	B	158	 158 	LEU	A	Protein	S	1
FT	#SUB	99	  99 	LEU	B	178	 178 	LYS	A	Protein	S	1
FT	#SUB	102	 102 	GLN	B	137	 137 	ARG	A	Protein	S	1
FT	#SUB	102	 102 	GLN	B	178	 178 	LYS	A	Protein	S	5
FT	#SUB	102	 102 	GLN	B	180	 180 	GLU	A	Protein	S	1
FT	#SUB	103	 103 	PRO	B	137	 137 	ARG	A	Protein	S	1
FT	#SUB	104	 104 	GLU	B	137	 137 	ARG	A	Protein	S	4
FT	#SUB	104	 104 	GLU	B	153	 153 	LEU	A	Protein	B	1
FT	#SUB	104	 104 	GLU	B	158	 158 	LEU	A	Protein	S	1
FT	#SUB	104	 104 	GLU	B	180	 180 	GLU	A	Protein	S	6
FT	#SUB	104	 104 	GLU	B	182	 182 	TYR	A	Protein	S	5
FT	#SUB	108	 108 	LYS	B	150	 150 	GLU	A	Protein	S	3
FT	#HET	7	   7 	ILE	B	6	202 	9DR	B	A	7
FT	#HET	8	   8 	VAL	B	5	201 	NDP	B	A	4
FT	#HET	8	   8 	VAL	B	6	202 	9DR	B	B	8
FT	#HET	9	   9 	ALA	B	5	201 	NDP	B	A	11
FT	#HET	9	   9 	ALA	B	6	202 	9DR	B	A	8
FT	#HET	16	  16 	ILE	B	5	201 	NDP	B	A	8
FT	#HET	17	  17 	GLY	B	5	201 	NDP	B	B	3
FT	#HET	18	  18 	LYS	B	5	201 	NDP	B	B	1
FT	#HET	20	  20 	GLY	B	5	201 	NDP	B	B	3
FT	#HET	21	  21 	ASP	B	5	201 	NDP	B	B	8
FT	#HET	22	  22 	LEU	B	5	201 	NDP	B	S	3
FT	#HET	22	  22 	LEU	B	6	202 	9DR	B	S	1
FT	#HET	24	  24 	TRP	B	5	201 	NDP	B	S	2
FT	#HET	28	  28 	ARG	B	7	203 	SO4	B	S	8
FT	#HET	30	  30 	GLU	B	6	202 	9DR	B	S	12
FT	#HET	31	  31 	PHE	B	6	202 	9DR	B	S	8
FT	#HET	31	  31 	PHE	B	7	203 	SO4	B	S	2
FT	#HET	34	  34 	PHE	B	6	202 	9DR	B	S	9
FT	#HET	35	  35 	GLN	B	6	202 	9DR	B	S	1
FT	#HET	35	  35 	GLN	B	7	203 	SO4	B	S	1
FT	#HET	53	  53 	GLY	B	5	201 	NDP	B	B	8
FT	#HET	54	  54 	LYS	B	5	201 	NDP	B	A	8
FT	#HET	55	  55 	LYS	B	5	201 	NDP	B	A	13
FT	#HET	56	  56 	THR	B	5	201 	NDP	B	A	11
FT	#HET	59	  59 	SER	B	5	201 	NDP	B	S	2
FT	#HET	59	  59 	SER	B	6	202 	9DR	B	A	3
FT	#HET	60	  60 	ILE	B	6	202 	9DR	B	S	2
FT	#HET	61	  61 	PRO	B	6	202 	9DR	B	S	1
FT	#HET	64	  64 	ASN	B	6	202 	9DR	B	S	1
FT	#HET	67	  67 	LEU	B	6	202 	9DR	B	S	2
FT	#HET	68	  68 	LYS	B	7	203 	SO4	B	S	3
FT	#HET	75	  75 	LEU	B	5	201 	NDP	B	A	7
FT	#HET	76	  76 	SER	B	5	201 	NDP	B	A	6
FT	#HET	77	  77 	ARG	B	5	201 	NDP	B	A	7
FT	#HET	77	  77 	ARG	B	8	204 	SO4	B	S	9
FT	#HET	78	  78 	GLU	B	5	201 	NDP	B	A	8
FT	#HET	91	  91 	ARG	B	5	201 	NDP	B	B	3
FT	#HET	91	  91 	ARG	B	8	204 	SO4	B	S	7
FT	#HET	92	  92 	SER	B	5	201 	NDP	B	B	2
FT	#HET	115	 115 	VAL	B	5	201 	NDP	B	B	3
FT	#HET	115	 115 	VAL	B	6	202 	9DR	B	A	4
FT	#HET	116	 116 	GLY	B	5	201 	NDP	B	B	3
FT	#HET	117	 117 	GLY	B	5	201 	NDP	B	B	10
FT	#HET	118	 118 	SER	B	5	201 	NDP	B	A	4
FT	#HET	119	 119 	SER	B	5	201 	NDP	B	A	7
FT	#HET	120	 120 	VAL	B	5	201 	NDP	B	A	5
FT	#HET	121	 121 	TYR	B	5	201 	NDP	B	S	2
FT	#HET	121	 121 	TYR	B	6	202 	9DR	B	S	1
FT	#HET	123	 123 	GLU	B	5	201 	NDP	B	S	4
FT	#HET	136	 136 	THR	B	6	202 	9DR	B	S	1
FT	#HET	146	 146 	THR	B	5	201 	NDP	B	S	5
CC	SEQUENCE	186 AA (ATOM);
CC	VGSLNCIVAV SQNMGIGKNG DLPWPPLRNE FRYFQRMTTT SSVEGKQNLV IMGKKTWFSI
CC	PEKNRPLKGR INLVLSRELK EPPQGAHFLS RSLDDALKLT EQPELANKVD MVWIVGGSSV
CC	YKEAMNHPGH LKLFVTRIMQ DFESDTFFPE IDLEKYKLLP EYPGVLSDVQ EEKGIKYKFE
CC	VYEKND
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLV
CC	ATOM   VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLV
CC	       **************************************************
CC	SEQRES IMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLT
CC	ATOM   IMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLT
CC	       **************************************************
CC	SEQRES EQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPE
CC	ATOM   EQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPE
CC	       **************************************************
CC	SEQRES IDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
CC	ATOM   IDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
CC	       ************************************
SQ	SEQUENCE	186 AA;      MW;         CN;
	VGSLNCIVAV SQNMGIGKNG DLPWPPLRNE FRYFQRMTTT SSVEGKQNLV IMGKKTWFSI
	PEKNRPLKGR INLVLSRELK EPPQGAHFLS RSLDDALKLT EQPELANKVD MVWIVGGSSV
	YKEAMNHPGH LKLFVTRIMQ DFESDTFFPE IDLEKYKLLP EYPGVLSDVQ EEKGIKYKFE
	VYEKND
//