ID	4I5CA	STANDARD;	PRT;	302	AA.
DT	CONVERTED FROM PDB (SEQRES) 4I5C
DE	Tyrosine-protein kinase JAK1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.100
CC	R-Factor	0.193
FT	#SUB	185	1037 	VAL	A	251	1103 	ARG	B	Protein	B	2
FT	#SUB	186	1038 	LYS	A	244	1096 	HIS	B	Protein	B	2
FT	#SUB	186	1038 	LYS	A	251	1103 	ARG	B	Protein	B	2
FT	#SUB	188	1040 	ASP	A	244	1096 	HIS	B	Protein	S	8
FT	#SUB	188	1040 	ASP	A	247	1099 	MET	B	Protein	A	6
FT	#SUB	188	1040 	ASP	A	251	1103 	ARG	B	Protein	S	5
FT	#SUB	189	1041 	ARG	A	243	1095 	THR	B	Protein	S	7
FT	#SUB	189	1041 	ARG	A	244	1096 	HIS	B	Protein	A	4
FT	#SUB	189	1041 	ARG	A	245	1097 	GLY	B	Protein	S	1
FT	#SUB	191	1043 	SER	A	246	1098 	GLN	B	Protein	B	1
FT	#SUB	193	1045 	VAL	A	246	1098 	GLN	B	Protein	S	3
FT	#SUB	201	1053 	LEU	A	247	1099 	MET	B	Protein	B	1
FT	#SUB	201	1053 	LEU	A	250	1102 	THR	B	Protein	B	3
FT	#SUB	202	1054 	MET	A	250	1102 	THR	B	Protein	B	2
FT	#SUB	202	1054 	MET	A	254	1106 	ASN	B	Protein	B	3
FT	#SUB	203	1055 	GLN	A	254	1106 	ASN	B	Protein	B	1
FT	#SUB	204	1056 	SER	A	251	1103 	ARG	B	Protein	S	1
FT	#SUB	243	1095 	THR	A	189	1041 	ARG	B	Protein	A	7
FT	#SUB	244	1096 	HIS	A	186	1038 	LYS	B	Protein	S	2
FT	#SUB	244	1096 	HIS	A	188	1040 	ASP	B	Protein	A	8
FT	#SUB	244	1096 	HIS	A	189	1041 	ARG	B	Protein	B	3
FT	#SUB	245	1097 	GLY	A	189	1041 	ARG	B	Protein	B	2
FT	#SUB	247	1099 	MET	A	188	1040 	ASP	B	Protein	S	8
FT	#SUB	247	1099 	MET	A	193	1045 	VAL	B	Protein	S	1
FT	#SUB	247	1099 	MET	A	201	1053 	LEU	B	Protein	S	1
FT	#SUB	247	1099 	MET	A	249	1101 	VAL	B	Protein	S	2
FT	#SUB	249	1101 	VAL	A	246	1098 	GLN	B	Protein	S	2
FT	#SUB	249	1101 	VAL	A	247	1099 	MET	B	Protein	S	1
FT	#SUB	250	1102 	THR	A	201	1053 	LEU	B	Protein	S	3
FT	#SUB	251	1103 	ARG	A	186	1038 	LYS	B	Protein	S	1
FT	#SUB	251	1103 	ARG	A	188	1040 	ASP	B	Protein	S	5
FT	#SUB	254	1106 	ASN	A	202	1054 	MET	B	Protein	S	4
FT	#SUB	254	1106 	ASN	A	203	1055 	GLN	B	Protein	S	3
FT	#SUB	257	1109 	LYS	A	257	1109 	LYS	B	Protein	S	1
FT	#HET	29	 881 	LEU	A	1	1201 	C5I	A	S	5
FT	#HET	30	 882 	GLY	A	1	1201 	C5I	A	B	5
FT	#HET	31	 883 	GLU	A	1	1201 	C5I	A	B	4
FT	#HET	32	 884 	GLY	A	1	1201 	C5I	A	B	2
FT	#HET	35	 887 	GLY	A	1	1201 	C5I	A	B	2
FT	#HET	36	 888 	LYS	A	1	1201 	C5I	A	B	2
FT	#HET	37	 889 	VAL	A	1	1201 	C5I	A	A	7
FT	#HET	54	 906 	ALA	A	1	1201 	C5I	A	S	4
FT	#HET	56	 908 	LYS	A	1	1201 	C5I	A	S	1
FT	#HET	86	 938 	VAL	A	1	1201 	C5I	A	S	2
FT	#HET	104	 956 	MET	A	1	1201 	C5I	A	S	2
FT	#HET	105	 957 	GLU	A	1	1201 	C5I	A	B	4
FT	#HET	106	 958 	PHE	A	1	1201 	C5I	A	A	5
FT	#HET	107	 959 	LEU	A	1	1201 	C5I	A	A	8
FT	#HET	110	 962 	GLY	A	1	1201 	C5I	A	B	1
FT	#HET	155	1007 	ARG	A	1	1201 	C5I	A	B	1
FT	#HET	156	1008 	ASN	A	1	1201 	C5I	A	S	2
FT	#HET	158	1010 	LEU	A	1	1201 	C5I	A	S	13
FT	#HET	168	1020 	GLY	A	1	1201 	C5I	A	B	3
FT	#HET	169	1021 	ASP	A	1	1201 	C5I	A	S	4
FT	#HET	246	1098 	GLN	A	5	1204 	EDO	B	A	3
FT	DISORDER	1	12
FT	DISORDER	61	64
FT	DISORDER	94	97
FT	DISORDER	179	179
CC	SEQUENCE	281 AA (ATOM);
CC	VDPTHFEKRF LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ VAVKSLKPNH IADLKKEIEI
CC	LRNLYHENIV KYKGICTNGI KLIMEFLPSG SLKEYLPKNK NKINLKQQLK YAVQICKGMD
CC	YLGSRQYVHR DLAARNVLVE SEHQVKIGDF GLTKAIETKE YYTVKDDRDS PVFWYAPECL
CC	MQSKFYIASD VWSFGVTLHE LLTYCDSDSS PMALFLKMIG PTHGQMTVTR LVNTLKEGKR
CC	LPCPPNCPDE VYQLMRKCWE FQPSNRTSFQ NLIEGFEALL K
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES GDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	ATOM   ------------VDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	                   **************************************
CC	SEQRES EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGI
CC	ATOM   EQVAVKSLKP----NHIADLKKEIEILRNLYHENIVKYKGICT----NGI
CC	       **********    *****************************    ***
CC	SEQRES KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	ATOM   KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	       **************************************************
CC	SEQRES DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	ATOM   DLAARNVLVESEHQVKIGDFGLTKAIET-KEYYTVKDDRDSPVFWYAPEC
CC	       **************************** *********************
CC	SEQRES LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	ATOM   LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	       **************************************************
CC	SEQRES RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	ATOM   RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	       **************************************************
CC	SEQRES LK
CC	ATOM   LK
CC	       **
SQ	SEQUENCE	302 AA;      MW;         CN;
	GDIVSEKKPA TEVDPTHFEK RFLKRIRDLG EGHFGKVELC RYDPEGDNTG EQVAVKSLKP
	ESGGNHIADL KKEIEILRNL YHENIVKYKG ICTEDGGNGI KLIMEFLPSG SLKEYLPKNK
	NKINLKQQLK YAVQICKGMD YLGSRQYVHR DLAARNVLVE SEHQVKIGDF GLTKAIETDK
	EYYTVKDDRD SPVFWYAPEC LMQSKFYIAS DVWSFGVTLH ELLTYCDSDS SPMALFLKMI
	GPTHGQMTVT RLVNTLKEGK RLPCPPNCPD EVYQLMRKCW EFQPSNRTSF QNLIEGFEAL
	LK
//
ID	4I5CB	STANDARD;	PRT;	302	AA.
DT	CONVERTED FROM PDB (SEQRES) 4I5C
DE	Tyrosine-protein kinase JAK1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.100
CC	R-Factor	0.193
FT	#SUB	186	1038 	LYS	B	244	1096 	HIS	A	Protein	B	2
FT	#SUB	186	1038 	LYS	B	251	1103 	ARG	A	Protein	B	1
FT	#SUB	188	1040 	ASP	B	244	1096 	HIS	A	Protein	S	8
FT	#SUB	188	1040 	ASP	B	247	1099 	MET	A	Protein	A	8
FT	#SUB	188	1040 	ASP	B	251	1103 	ARG	A	Protein	S	5
FT	#SUB	189	1041 	ARG	B	243	1095 	THR	A	Protein	S	7
FT	#SUB	189	1041 	ARG	B	244	1096 	HIS	A	Protein	A	3
FT	#SUB	189	1041 	ARG	B	245	1097 	GLY	A	Protein	S	2
FT	#SUB	193	1045 	VAL	B	247	1099 	MET	A	Protein	S	1
FT	#SUB	201	1053 	LEU	B	247	1099 	MET	A	Protein	B	1
FT	#SUB	201	1053 	LEU	B	250	1102 	THR	A	Protein	B	3
FT	#SUB	202	1054 	MET	B	254	1106 	ASN	A	Protein	B	4
FT	#SUB	203	1055 	GLN	B	254	1106 	ASN	A	Protein	S	3
FT	#SUB	243	1095 	THR	B	189	1041 	ARG	A	Protein	A	7
FT	#SUB	244	1096 	HIS	B	186	1038 	LYS	A	Protein	S	2
FT	#SUB	244	1096 	HIS	B	188	1040 	ASP	A	Protein	A	8
FT	#SUB	244	1096 	HIS	B	189	1041 	ARG	A	Protein	B	4
FT	#SUB	245	1097 	GLY	B	189	1041 	ARG	A	Protein	B	1
FT	#SUB	246	1098 	GLN	B	191	1043 	SER	A	Protein	S	1
FT	#SUB	246	1098 	GLN	B	193	1045 	VAL	A	Protein	S	3
FT	#SUB	246	1098 	GLN	B	249	1101 	VAL	A	Protein	S	2
FT	#SUB	247	1099 	MET	B	188	1040 	ASP	A	Protein	S	6
FT	#SUB	247	1099 	MET	B	201	1053 	LEU	A	Protein	S	1
FT	#SUB	247	1099 	MET	B	249	1101 	VAL	A	Protein	S	1
FT	#SUB	249	1101 	VAL	B	247	1099 	MET	A	Protein	S	2
FT	#SUB	250	1102 	THR	B	201	1053 	LEU	A	Protein	S	3
FT	#SUB	250	1102 	THR	B	202	1054 	MET	A	Protein	S	2
FT	#SUB	251	1103 	ARG	B	185	1037 	VAL	A	Protein	S	2
FT	#SUB	251	1103 	ARG	B	186	1038 	LYS	A	Protein	S	2
FT	#SUB	251	1103 	ARG	B	188	1040 	ASP	A	Protein	S	5
FT	#SUB	251	1103 	ARG	B	204	1056 	SER	A	Protein	S	1
FT	#SUB	254	1106 	ASN	B	202	1054 	MET	A	Protein	S	3
FT	#SUB	254	1106 	ASN	B	203	1055 	GLN	A	Protein	S	1
FT	#SUB	257	1109 	LYS	B	257	1109 	LYS	A	Protein	S	1
FT	#HET	14	 866 	ASP	B	3	1202 	EDO	B	B	2
FT	#HET	15	 867 	PRO	B	3	1202 	EDO	B	B	7
FT	#HET	17	 869 	HIS	B	3	1202 	EDO	B	B	3
FT	#HET	18	 870 	PHE	B	3	1202 	EDO	B	S	6
FT	#HET	23	 875 	LEU	B	4	1203 	EDO	B	A	3
FT	#HET	25	 877 	ARG	B	4	1203 	EDO	B	B	1
FT	#HET	27	 879 	ARG	B	2	1201 	EDO	B	S	6
FT	#HET	29	 881 	LEU	B	2	1201 	EDO	B	S	3
FT	#HET	29	 881 	LEU	B	6	1205 	C5I	B	S	4
FT	#HET	30	 882 	GLY	B	6	1205 	C5I	B	B	5
FT	#HET	31	 883 	GLU	B	6	1205 	C5I	B	B	7
FT	#HET	32	 884 	GLY	B	6	1205 	C5I	B	B	5
FT	#HET	35	 887 	GLY	B	6	1205 	C5I	B	B	2
FT	#HET	36	 888 	LYS	B	6	1205 	C5I	B	B	3
FT	#HET	37	 889 	VAL	B	6	1205 	C5I	B	A	7
FT	#HET	38	 890 	GLU	B	4	1203 	EDO	B	S	3
FT	#HET	40	 892 	CYS	B	4	1203 	EDO	B	S	2
FT	#HET	42	 894 	TYR	B	3	1202 	EDO	B	S	2
FT	#HET	54	 906 	ALA	B	6	1205 	C5I	B	S	4
FT	#HET	55	 907 	VAL	B	4	1203 	EDO	B	S	1
FT	#HET	56	 908 	LYS	B	6	1205 	C5I	B	S	2
FT	#HET	86	 938 	VAL	B	6	1205 	C5I	B	S	1
FT	#HET	101	 953 	LYS	B	4	1203 	EDO	B	S	5
FT	#HET	104	 956 	MET	B	6	1205 	C5I	B	S	3
FT	#HET	105	 957 	GLU	B	6	1205 	C5I	B	B	4
FT	#HET	106	 958 	PHE	B	2	1201 	EDO	B	S	1
FT	#HET	106	 958 	PHE	B	6	1205 	C5I	B	A	5
FT	#HET	107	 959 	LEU	B	6	1205 	C5I	B	A	7
FT	#HET	108	 960 	PRO	B	2	1201 	EDO	B	B	3
FT	#HET	110	 962 	GLY	B	2	1201 	EDO	B	B	3
FT	#HET	110	 962 	GLY	B	6	1205 	C5I	B	B	1
FT	#HET	155	1007 	ARG	B	6	1205 	C5I	B	B	2
FT	#HET	156	1008 	ASN	B	6	1205 	C5I	B	S	2
FT	#HET	158	1010 	LEU	B	6	1205 	C5I	B	S	12
FT	#HET	168	1020 	GLY	B	6	1205 	C5I	B	B	3
FT	#HET	169	1021 	ASP	B	6	1205 	C5I	B	S	3
FT	#HET	245	1097 	GLY	B	5	1204 	EDO	B	B	3
FT	#HET	246	1098 	GLN	B	5	1204 	EDO	B	A	5
FT	DISORDER	61	65
FT	DISORDER	95	98
CC	SEQUENCE	293 AA (ATOM);
CC	GDIVSEKKPA TEVDPTHFEK RFLKRIRDLG EGHFGKVELC RYDPEGDNTG EQVAVKSLKP
CC	HIADLKKEIE ILRNLYHENI VKYKGICTEG IKLIMEFLPS GSLKEYLPKN KNKINLKQQL
CC	KYAVQICKGM DYLGSRQYVH RDLAARNVLV ESEHQVKIGD FGLTKAIETD KEYYTVKDDR
CC	DSPVFWYAPE CLMQSKFYIA SDVWSFGVTL HELLTYCDSD SSPMALFLKM IGPTHGQMTV
CC	TRLVNTLKEG KRLPCPPNCP DEVYQLMRKC WEFQPSNRTS FQNLIEGFEA LLK
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES GDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	ATOM   GDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	       **************************************************
CC	SEQRES EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGI
CC	ATOM   EQVAVKSLKP-----HIADLKKEIEILRNLYHENIVKYKGICTE----GI
CC	       **********     *****************************    **
CC	SEQRES KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	ATOM   KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	       **************************************************
CC	SEQRES DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	ATOM   DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	       **************************************************
CC	SEQRES LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	ATOM   LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	       **************************************************
CC	SEQRES RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	ATOM   RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	       **************************************************
CC	SEQRES LK
CC	ATOM   LK
CC	       **
SQ	SEQUENCE	302 AA;      MW;         CN;
	GDIVSEKKPA TEVDPTHFEK RFLKRIRDLG EGHFGKVELC RYDPEGDNTG EQVAVKSLKP
	ESGGNHIADL KKEIEILRNL YHENIVKYKG ICTEDGGNGI KLIMEFLPSG SLKEYLPKNK
	NKINLKQQLK YAVQICKGMD YLGSRQYVHR DLAARNVLVE SEHQVKIGDF GLTKAIETDK
	EYYTVKDDRD SPVFWYAPEC LMQSKFYIAS DVWSFGVTLH ELLTYCDSDS SPMALFLKMI
	GPTHGQMTVT RLVNTLKEGK RLPCPPNCPD EVYQLMRKCW EFQPSNRTSF QNLIEGFEAL
	LK
//