ID	4GB9A	STANDARD;	PRT;	966	AA.
DT	CONVERTED FROM PDB (SEQRES) 4GB9
DE	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isof
DE	orm
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.440
CC	R-Factor	0.206
FT	#HET	660	 802 	LYS	A	1	1201 	0WR	A	S	2
FT	#HET	662	 804 	MET	A	1	1201 	0WR	A	S	1
FT	#HET	668	 810 	PRO	A	1	1201 	0WR	A	S	1
FT	#HET	670	 812 	TRP	A	1	1201 	0WR	A	S	8
FT	#HET	689	 831 	ILE	A	1	1201 	0WR	A	S	4
FT	#HET	691	 833 	LYS	A	1	1201 	0WR	A	S	9
FT	#HET	699	 841 	ASP	A	1	1201 	0WR	A	S	2
FT	#HET	725	 867 	TYR	A	1	1201 	0WR	A	S	5
FT	#HET	737	 879 	ILE	A	1	1201 	0WR	A	S	8
FT	#HET	738	 880 	GLU	A	1	1201 	0WR	A	B	3
FT	#HET	739	 881 	ILE	A	1	1201 	0WR	A	B	2
FT	#HET	740	 882 	VAL	A	1	1201 	0WR	A	A	11
FT	#HET	745	 887 	THR	A	1	1201 	0WR	A	S	2
FT	#HET	748	 890 	LYS	A	1	1201 	0WR	A	S	5
FT	#HET	811	 953 	MET	A	1	1201 	0WR	A	S	6
FT	#HET	821	 963 	ILE	A	1	1201 	0WR	A	S	8
FT	#HET	822	 964 	ASP	A	1	1201 	0WR	A	A	14
FT	DISORDER	112	124
FT	DISORDER	181	214
FT	DISORDER	294	317
FT	DISORDER	348	354
FT	DISORDER	381	382
FT	DISORDER	387	402
FT	DISORDER	826	838
FT	DISORDER	950	966
CC	Miss-SC	1
CC	SEQUENCE	840 AA (ATOM);
CC	MSEESQAFQR QLTALIGYDV TDVSNVHDDE LEFTRRGLVT PRMAEVASRD PKLYAMHPWV
CC	TSKPLPEYLW KKIANNCIFI VIHRSTTSQT IKVSPDDTPG AILQSFFTKM AEQDFVLRVC
CC	GRDEYLVGET PIKNFQWVRH CLKNGEEIHV VLDTPPDPAL DEVRKEECDR KFRVKIRGID
CC	IPVLPRNTDL TVFVEANIQH GQQVLCQRRT SPKPFTEEVL WNVWLEFSIK IKDLPKGALL
CC	NLQIYCLLYY VNLLLIDHRF LLRRGEYVLH MWQISGFNAD KLTSATNPDK ENSMSISILL
CC	DNHPIAAEMP NQLRKQLEAI IATDPLNPLT AEDKELLWHF RYESLKHPKA YPKLFSSVKW
CC	GQQEIVAKTY QLLARREVWD QSALDVGLTM QLLDCNFSDE NVRAIAVQKL ESLEDDDVLH
CC	YLLQLVQAVK FEPYHDSALA RFLLKRGLRN KRIGHFLFWF LRSEIAQSRH YQQRFAVILE
CC	AYLRGCGTAM LHDFTQQVQV IEMLQKVTLD IKSLSAEKYD VSSQVISQLK QKLENLQNSQ
CC	LPESFRVPYD PGLKAGALAI EKCKVMASKK KPLWLEFKCA DPTALSNETI GIIFKHGDDL
CC	RQDMLILQIL RIMESIWETE SLDLCLLPYG CISTGDKIGM IEIVKDATTI AKIQQSTVGN
CC	TGAFKDEVLN HWLKEKSPTE EKFQAAVERF VYSCAGYCVA TFVLGIGDRH NDNIMITETG
CC	NLFHIDFGHE RVPFVLTPDF LFVMGTSGKK TSPHFQKFQD ICVKAYLALR HHTNLLIILF
CC	SMMLMTGMPQ LTSKEDIEYI RDALTVGKNE EDAKKYFLDQ IEVCRDKGWT VQFNWFLHLV
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRD
CC	ATOM   MSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRD
CC	       **************************************************
CC	SEQRES PKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPG
CC	ATOM   PKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPG
CC	       **************************************************
CC	SEQRES AILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQW
CC	ATOM   AILQSFFTKMA-------------EQDFVLRVCGRDEYLVGETPIKNFQW
CC	       ***********             **************************
CC	SEQRES VRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIH
CC	ATOM   VRHCLKNGEEIHVVLDTPPDPALDEVRKEE--------------------
CC	       ******************************                    
CC	SEQRES GKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQ
CC	ATOM   --------------CDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQ
CC	                     ************************************
CC	SEQRES VLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALS
CC	ATOM   VLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYC-------
CC	       *******************************************       
CC	SEQRES SKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGE
CC	ATOM   -----------------LLYYVNLLLIDHRFLLRRGEYVLHMWQISG---
CC	                        ******************************   
CC	SEQRES DQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDR
CC	ATOM   ----FNADKLTSATNPDKENSMSISILLDN--HPIA--------------
CC	           **************************  ****              
CC	SEQRES VRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKL
CC	ATOM   --AEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKL
CC	         ************************************************
CC	SEQRES FSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRA
CC	ATOM   FSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRA
CC	       **************************************************
CC	SEQRES IAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIG
CC	ATOM   IAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIG
CC	       **************************************************
CC	SEQRES HFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEML
CC	ATOM   HFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEML
CC	       **************************************************
CC	SEQRES QKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLK
CC	ATOM   QKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLK
CC	       **************************************************
CC	SEQRES AGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDM
CC	ATOM   AGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDM
CC	       **************************************************
CC	SEQRES LILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQ
CC	ATOM   LILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQ
CC	       **************************************************
CC	SEQRES QSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVL
CC	ATOM   QSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVL
CC	       **************************************************
CC	SEQRES GIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFL
CC	ATOM   GIGDRHNDNIMITETGNLFHIDFGH-------------ERVPFVLTPDFL
CC	       *************************             ************
CC	SEQRES FVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQL
CC	ATOM   FVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQL
CC	       **************************************************
CC	SEQRES TSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVL
CC	ATOM   TSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLV-
CC	       ************************************************* 
CC	SEQRES GIKQGEKHSAHHHHHH
CC	ATOM   ----------------
CC	                       
SQ	SEQUENCE	966 AA;      MW;         CN;
	MSEESQAFQR QLTALIGYDV TDVSNVHDDE LEFTRRGLVT PRMAEVASRD PKLYAMHPWV
	TSKPLPEYLW KKIANNCIFI VIHRSTTSQT IKVSPDDTPG AILQSFFTKM AKKKSLMDIP
	ESQSEQDFVL RVCGRDEYLV GETPIKNFQW VRHCLKNGEE IHVVLDTPPD PALDEVRKEE
	WPLVDDCTGV TGYHEQLTIH GKDHESVFTV SLWDCDRKFR VKIRGIDIPV LPRNTDLTVF
	VEANIQHGQQ VLCQRRTSPK PFTEEVLWNV WLEFSIKIKD LPKGALLNLQ IYCGKAPALS
	SKASAESPSS ESKGKVQLLY YVNLLLIDHR FLLRRGEYVL HMWQISGKGE DQGSFNADKL
	TSATNPDKEN SMSISILLDN YCHPIALPKH QPTPDPEGDR VRAEMPNQLR KQLEAIIATD
	PLNPLTAEDK ELLWHFRYES LKHPKAYPKL FSSVKWGQQE IVAKTYQLLA RREVWDQSAL
	DVGLTMQLLD CNFSDENVRA IAVQKLESLE DDDVLHYLLQ LVQAVKFEPY HDSALARFLL
	KRGLRNKRIG HFLFWFLRSE IAQSRHYQQR FAVILEAYLR GCGTAMLHDF TQQVQVIEML
	QKVTLDIKSL SAEKYDVSSQ VISQLKQKLE NLQNSQLPES FRVPYDPGLK AGALAIEKCK
	VMASKKKPLW LEFKCADPTA LSNETIGIIF KHGDDLRQDM LILQILRIME SIWETESLDL
	CLLPYGCIST GDKIGMIEIV KDATTIAKIQ QSTVGNTGAF KDEVLNHWLK EKSPTEEKFQ
	AAVERFVYSC AGYCVATFVL GIGDRHNDNI MITETGNLFH IDFGHILGNY KSFLGINKER
	VPFVLTPDFL FVMGTSGKKT SPHFQKFQDI CVKAYLALRH HTNLLIILFS MMLMTGMPQL
	TSKEDIEYIR DALTVGKNEE DAKKYFLDQI EVCRDKGWTV QFNWFLHLVL GIKQGEKHSA
	HHHHHH
//