ID	4FADA	STANDARD;	PRT;	966	AA.
DT	CONVERTED FROM PDB (SEQRES) 4FAD
DE	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isof
DE	orm
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.700
CC	R-Factor	0.262
FT	#HET	662	 804 	MET	A	1	1201 	0TB	A	S	2
FT	#HET	670	 812 	TRP	A	1	1201 	0TB	A	S	1
FT	#HET	689	 831 	ILE	A	1	1201 	0TB	A	S	5
FT	#HET	691	 833 	LYS	A	1	1201 	0TB	A	S	8
FT	#HET	699	 841 	ASP	A	1	1201 	0TB	A	S	3
FT	#HET	725	 867 	TYR	A	1	1201 	0TB	A	S	6
FT	#HET	737	 879 	ILE	A	1	1201 	0TB	A	S	9
FT	#HET	738	 880 	GLU	A	1	1201 	0TB	A	B	2
FT	#HET	739	 881 	ILE	A	1	1201 	0TB	A	A	3
FT	#HET	740	 882 	VAL	A	1	1201 	0TB	A	A	13
FT	#HET	743	 885 	ALA	A	1	1201 	0TB	A	S	1
FT	#HET	745	 887 	THR	A	1	1201 	0TB	A	S	1
FT	#HET	811	 953 	MET	A	1	1201 	0TB	A	S	9
FT	#HET	821	 963 	ILE	A	1	1201 	0TB	A	S	3
FT	#HET	822	 964 	ASP	A	1	1201 	0TB	A	A	13
FT	DISORDER	1	1
FT	DISORDER	113	126
FT	DISORDER	181	210
FT	DISORDER	232	236
FT	DISORDER	294	315
FT	DISORDER	348	354
FT	DISORDER	381	384
FT	DISORDER	389	401
FT	DISORDER	612	617
FT	DISORDER	831	840
FT	DISORDER	952	966
CC	SEQUENCE	839 AA (ATOM);
CC	SEESQAFQRQ LTALIGYDVT DVSNVHDDEL EFTRRGLVTP RMAEVASRDP KLYAMHPWVT
CC	SKPLPEYLWK KIANNCIFIV IHRSTTSQTI KVSPDDTPGA ILQSFFTKMA KDFVLRVCGR
CC	DEYLVGETPI KNFQWVRHCL KNGEEIHVVL DTPPDPALDE VRKEESLWDC DRKFRVKIRG
CC	IDIPVLLTVF VEANIQHGQQ VLCQRRTSPK PFTEEVLWNV WLEFSIKIKD LPKGALLNLQ
CC	IYCVQLLYYV NLLLIDHRFL LRRGEYVLHM WQISGFNADK LTSATNPDKE NSMSISILLD
CC	NIALPRAEMP NQLRKQLEAI IATDPLNPLT AEDKELLWHF RYESLKHPKA YPKLFSSVKW
CC	GQQEIVAKTY QLLARREVWD QSALDVGLTM QLLDCNFSDE NVRAIAVQKL ESLEDDDVLH
CC	YLLQLVQAVK FEPYHDSALA RFLLKRGLRN KRIGHFLFWF LRSEIAQSRH YQQRFAVILE
CC	AYLRGCGTAM LHDFTQQVQV IEMLQKVTLD IKSLSSSQVI SQLKQKLENL QNSQLPESFR
CC	VPYDPGLKAG ALAIEKCKVM ASKKKPLWLE FKCADPTALS NETIGIIFKH GDDLRQDMLI
CC	LQILRIMESI WETESLDLCL LPYGCISTGD KIGMIEIVKD ATTIAKIQQS TVGNTGAFKD
CC	EVLNHWLKEK SPTEEKFQAA VERFVYSCAG YCVATFVLGI GDRHNDNIMI TETGNLFHID
CC	FGHILGNYVP FVLTPDFLFV MGTSGKKTSP HFQKFQDICV KAYLALRHHT NLLIILFSMM
CC	LMTGMPQLTS KEDIEYIRDA LTVGKNEEDA KKYFLDQIEV CRDKGWTVQF NWFLHLVLG
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRD
CC	ATOM   -SEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRD
CC	        *************************************************
CC	SEQRES PKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPG
CC	ATOM   PKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPG
CC	       **************************************************
CC	SEQRES AILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQW
CC	ATOM   AILQSFFTKMAK--------------DFVLRVCGRDEYLVGETPIKNFQW
CC	       ************              ************************
CC	SEQRES VRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIH
CC	ATOM   VRHCLKNGEEIHVVLDTPPDPALDEVRKEE--------------------
CC	       ******************************                    
CC	SEQRES GKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQ
CC	ATOM   ----------SLWDCDRKFRVKIRGIDIPVL-----LTVFVEANIQHGQQ
CC	                 *********************     **************
CC	SEQRES VLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALS
CC	ATOM   VLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYC-------
CC	       *******************************************       
CC	SEQRES SKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGE
CC	ATOM   ---------------VQLLYYVNLLLIDHRFLLRRGEYVLHMWQISG---
CC	                      ********************************   
CC	SEQRES DQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDR
CC	ATOM   ----FNADKLTSATNPDKENSMSISILLDN----IALP------------
CC	           **************************    ****            
CC	SEQRES VRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKL
CC	ATOM   -RAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKL
CC	        *************************************************
CC	SEQRES FSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRA
CC	ATOM   FSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRA
CC	       **************************************************
CC	SEQRES IAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIG
CC	ATOM   IAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIG
CC	       **************************************************
CC	SEQRES HFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEML
CC	ATOM   HFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEML
CC	       **************************************************
CC	SEQRES QKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLK
CC	ATOM   QKVTLDIKSLS------SSQVISQLKQKLENLQNSQLPESFRVPYDPGLK
CC	       ***********      *********************************
CC	SEQRES AGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDM
CC	ATOM   AGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDM
CC	       **************************************************
CC	SEQRES LILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQ
CC	ATOM   LILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQ
CC	       **************************************************
CC	SEQRES QSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVL
CC	ATOM   QSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVL
CC	       **************************************************
CC	SEQRES GIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFL
CC	ATOM   GIGDRHNDNIMITETGNLFHIDFGHILGNY----------VPFVLTPDFL
CC	       ******************************          **********
CC	SEQRES FVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQL
CC	ATOM   FVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQL
CC	       **************************************************
CC	SEQRES TSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVL
CC	ATOM   TSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVL
CC	       **************************************************
CC	SEQRES GIKQGEKHSAHHHHHH
CC	ATOM   G---------------
CC	       *               
SQ	SEQUENCE	966 AA;      MW;         CN;
	MSEESQAFQR QLTALIGYDV TDVSNVHDDE LEFTRRGLVT PRMAEVASRD PKLYAMHPWV
	TSKPLPEYLW KKIANNCIFI VIHRSTTSQT IKVSPDDTPG AILQSFFTKM AKKKSLMDIP
	ESQSEQDFVL RVCGRDEYLV GETPIKNFQW VRHCLKNGEE IHVVLDTPPD PALDEVRKEE
	WPLVDDCTGV TGYHEQLTIH GKDHESVFTV SLWDCDRKFR VKIRGIDIPV LPRNTDLTVF
	VEANIQHGQQ VLCQRRTSPK PFTEEVLWNV WLEFSIKIKD LPKGALLNLQ IYCGKAPALS
	SKASAESPSS ESKGKVQLLY YVNLLLIDHR FLLRRGEYVL HMWQISGKGE DQGSFNADKL
	TSATNPDKEN SMSISILLDN YCHPIALPKH QPTPDPEGDR VRAEMPNQLR KQLEAIIATD
	PLNPLTAEDK ELLWHFRYES LKHPKAYPKL FSSVKWGQQE IVAKTYQLLA RREVWDQSAL
	DVGLTMQLLD CNFSDENVRA IAVQKLESLE DDDVLHYLLQ LVQAVKFEPY HDSALARFLL
	KRGLRNKRIG HFLFWFLRSE IAQSRHYQQR FAVILEAYLR GCGTAMLHDF TQQVQVIEML
	QKVTLDIKSL SAEKYDVSSQ VISQLKQKLE NLQNSQLPES FRVPYDPGLK AGALAIEKCK
	VMASKKKPLW LEFKCADPTA LSNETIGIIF KHGDDLRQDM LILQILRIME SIWETESLDL
	CLLPYGCIST GDKIGMIEIV KDATTIAKIQ QSTVGNTGAF KDEVLNHWLK EKSPTEEKFQ
	AAVERFVYSC AGYCVATFVL GIGDRHNDNI MITETGNLFH IDFGHILGNY KSFLGINKER
	VPFVLTPDFL FVMGTSGKKT SPHFQKFQDI CVKAYLALRH HTNLLIILFS MMLMTGMPQL
	TSKEDIEYIR DALTVGKNEE DAKKYFLDQI EVCRDKGWTV QFNWFLHLVL GIKQGEKHSA
	HHHHHH
//