ID	4FA6A	STANDARD;	PRT;	966	AA.
DT	CONVERTED FROM PDB (SEQRES) 4FA6
DE	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isof
DE	orm
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.700
CC	R-Factor	0.208
FT	#HET	662	 804 	MET	A	1	1201 	0TA	A	S	10
FT	#HET	670	 812 	TRP	A	1	1201 	0TA	A	S	7
FT	#HET	689	 831 	ILE	A	1	1201 	0TA	A	S	8
FT	#HET	691	 833 	LYS	A	1	1201 	0TA	A	S	5
FT	#HET	725	 867 	TYR	A	1	1201 	0TA	A	S	30
FT	#HET	737	 879 	ILE	A	1	1201 	0TA	A	S	7
FT	#HET	738	 880 	GLU	A	1	1201 	0TA	A	B	7
FT	#HET	739	 881 	ILE	A	1	1201 	0TA	A	A	4
FT	#HET	740	 882 	VAL	A	1	1201 	0TA	A	A	20
FT	#HET	743	 885 	ALA	A	1	1201 	0TA	A	S	1
FT	#HET	745	 887 	THR	A	1	1201 	0TA	A	S	3
FT	#HET	748	 890 	LYS	A	1	1201 	0TA	A	S	1
FT	#HET	811	 953 	MET	A	1	1201 	0TA	A	S	11
FT	#HET	819	 961 	PHE	A	1	1201 	0TA	A	S	4
FT	#HET	821	 963 	ILE	A	1	1201 	0TA	A	S	13
FT	#HET	822	 964 	ASP	A	1	1201 	0TA	A	A	17
FT	DISORDER	1	1
FT	DISORDER	113	126
FT	DISORDER	181	214
FT	DISORDER	294	315
FT	DISORDER	348	354
FT	DISORDER	385	401
FT	DISORDER	826	838
FT	DISORDER	951	966
CC	SEQUENCE	842 AA (ATOM);
CC	SEESQAFQRQ LTALIGYDVT DVSNVHDDEL EFTRRGLVTP RMAEVASRDP KLYAMHPWVT
CC	SKPLPEYLWK KIANNCIFIV IHRSTTSQTI KVSPDDTPGA ILQSFFTKMA KDFVLRVCGR
CC	DEYLVGETPI KNFQWVRHCL KNGEEIHVVL DTPPDPALDE VRKEECDRKF RVKIRGIDIP
CC	VLPRNTDLTV FVEANIQHGQ QVLCQRRTSP KPFTEEVLWN VWLEFSIKIK DLPKGALLNL
CC	QIYCVQLLYY VNLLLIDHRF LLRRGEYVLH MWQISGFNAD KLTSATNPDK ENSMSISILL
CC	DNYCHPRAEM PNQLRKQLEA IIATDPLNPL TAEDKELLWH FRYESLKHPK AYPKLFSSVK
CC	WGQQEIVAKT YQLLARREVW DQSALDVGLT MQLLDCNFSD ENVRAIAVQK LESLEDDDVL
CC	HYLLQLVQAV KFEPYHDSAL ARFLLKRGLR NKRIGHFLFW FLRSEIAQSR HYQQRFAVIL
CC	EAYLRGCGTA MLHDFTQQVQ VIEMLQKVTL DIKSLSAEKY DVSSQVISQL KQKLENLQNS
CC	QLPESFRVPY DPGLKAGALA IEKCKVMASK KKPLWLEFKC ADPTALSNET IGIIFKHGDD
CC	LRQDMLILQI LRIMESIWET ESLDLCLLPY GCISTGDKIG MIEIVKDATT IAKIQQSTVG
CC	NTGAFKDEVL NHWLKEKSPT EEKFQAAVER FVYSCAGYCV ATFVLGIGDR HNDNIMITET
CC	GNLFHIDFGH ERVPFVLTPD FLFVMGTSGK KTSPHFQKFQ DICVKAYLAL RHHTNLLIIL
CC	FSMMLMTGMP QLTSKEDIEY IRDALTVGKN EEDAKKYFLD QIEVCRDKGW TVQFNWFLHL
CC	VL
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRD
CC	ATOM   -SEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRD
CC	        *************************************************
CC	SEQRES PKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPG
CC	ATOM   PKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPG
CC	       **************************************************
CC	SEQRES AILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQW
CC	ATOM   AILQSFFTKMAK--------------DFVLRVCGRDEYLVGETPIKNFQW
CC	       ************              ************************
CC	SEQRES VRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIH
CC	ATOM   VRHCLKNGEEIHVVLDTPPDPALDEVRKEE--------------------
CC	       ******************************                    
CC	SEQRES GKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQ
CC	ATOM   --------------CDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQ
CC	                     ************************************
CC	SEQRES VLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALS
CC	ATOM   VLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYC-------
CC	       *******************************************       
CC	SEQRES SKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGE
CC	ATOM   ---------------VQLLYYVNLLLIDHRFLLRRGEYVLHMWQISG---
CC	                      ********************************   
CC	SEQRES DQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDR
CC	ATOM   ----FNADKLTSATNPDKENSMSISILLDNYCHP----------------
CC	           ******************************                
CC	SEQRES VRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKL
CC	ATOM   -RAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKL
CC	        *************************************************
CC	SEQRES FSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRA
CC	ATOM   FSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRA
CC	       **************************************************
CC	SEQRES IAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIG
CC	ATOM   IAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIG
CC	       **************************************************
CC	SEQRES HFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEML
CC	ATOM   HFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEML
CC	       **************************************************
CC	SEQRES QKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLK
CC	ATOM   QKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLK
CC	       **************************************************
CC	SEQRES AGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDM
CC	ATOM   AGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDM
CC	       **************************************************
CC	SEQRES LILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQ
CC	ATOM   LILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQ
CC	       **************************************************
CC	SEQRES QSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVL
CC	ATOM   QSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVL
CC	       **************************************************
CC	SEQRES GIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFL
CC	ATOM   GIGDRHNDNIMITETGNLFHIDFGH-------------ERVPFVLTPDFL
CC	       *************************             ************
CC	SEQRES FVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQL
CC	ATOM   FVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQL
CC	       **************************************************
CC	SEQRES TSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVL
CC	ATOM   TSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVL
CC	       **************************************************
CC	SEQRES GIKQGEKHSAHHHHHH
CC	ATOM   ----------------
CC	                       
SQ	SEQUENCE	966 AA;      MW;         CN;
	MSEESQAFQR QLTALIGYDV TDVSNVHDDE LEFTRRGLVT PRMAEVASRD PKLYAMHPWV
	TSKPLPEYLW KKIANNCIFI VIHRSTTSQT IKVSPDDTPG AILQSFFTKM AKKKSLMDIP
	ESQSEQDFVL RVCGRDEYLV GETPIKNFQW VRHCLKNGEE IHVVLDTPPD PALDEVRKEE
	WPLVDDCTGV TGYHEQLTIH GKDHESVFTV SLWDCDRKFR VKIRGIDIPV LPRNTDLTVF
	VEANIQHGQQ VLCQRRTSPK PFTEEVLWNV WLEFSIKIKD LPKGALLNLQ IYCGKAPALS
	SKASAESPSS ESKGKVQLLY YVNLLLIDHR FLLRRGEYVL HMWQISGKGE DQGSFNADKL
	TSATNPDKEN SMSISILLDN YCHPIALPKH QPTPDPEGDR VRAEMPNQLR KQLEAIIATD
	PLNPLTAEDK ELLWHFRYES LKHPKAYPKL FSSVKWGQQE IVAKTYQLLA RREVWDQSAL
	DVGLTMQLLD CNFSDENVRA IAVQKLESLE DDDVLHYLLQ LVQAVKFEPY HDSALARFLL
	KRGLRNKRIG HFLFWFLRSE IAQSRHYQQR FAVILEAYLR GCGTAMLHDF TQQVQVIEML
	QKVTLDIKSL SAEKYDVSSQ VISQLKQKLE NLQNSQLPES FRVPYDPGLK AGALAIEKCK
	VMASKKKPLW LEFKCADPTA LSNETIGIIF KHGDDLRQDM LILQILRIME SIWETESLDL
	CLLPYGCIST GDKIGMIEIV KDATTIAKIQ QSTVGNTGAF KDEVLNHWLK EKSPTEEKFQ
	AAVERFVYSC AGYCVATFVL GIGDRHNDNI MITETGNLFH IDFGHILGNY KSFLGINKER
	VPFVLTPDFL FVMGTSGKKT SPHFQKFQDI CVKAYLALRH HTNLLIILFS MMLMTGMPQL
	TSKEDIEYIR DALTVGKNEE DAKKYFLDQI EVCRDKGWTV QFNWFLHLVL GIKQGEKHSA
	HHHHHH
//