ID	4F70A	STANDARD;	PRT;	405	AA.
DT	CONVERTED FROM PDB (SEQRES) 4F70
DE	Cyclin-dependent kinase 8
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	3.000
CC	R-Factor	0.204
FT	#SUB	2	   0 	LYS	A	134	 130 	TYR	B	Protein	S	1
FT	#SUB	2	   0 	LYS	A	264	 260 	PRO	B	Protein	B	1
FT	#SUB	3	   1 	MET	A	84	  80 	SER	B	Protein	A	3
FT	#SUB	3	   1 	MET	A	145	 141 	TYR	B	Protein	S	5
FT	#SUB	3	   1 	MET	A	264	 260 	PRO	B	Protein	B	1
FT	#SUB	3	   1 	MET	A	265	 261 	LYS	B	Protein	B	1
FT	#SUB	4	   2 	ASP	A	83	  79 	LYS	B	Protein	S	2
FT	#SUB	4	   2 	ASP	A	84	  80 	SER	B	Protein	A	3
FT	#SUB	4	   2 	ASP	A	264	 260 	PRO	B	Protein	A	4
FT	#SUB	4	   2 	ASP	A	265	 261 	LYS	B	Protein	A	6
FT	#SUB	5	   3 	TYR	A	265	 261 	LYS	B	Protein	A	3
FT	#SUB	5	   3 	TYR	A	267	 263 	PRO	B	Protein	S	1
FT	#SUB	5	   3 	TYR	A	268	 264 	PRO	B	Protein	S	1
FT	#SUB	6	   4 	ASP	A	265	 261 	LYS	B	Protein	S	3
FT	#SUB	7	   5 	PHE	A	80	  76 	TYR	B	Protein	S	4
FT	#SUB	7	   5 	PHE	A	84	  80 	SER	B	Protein	S	4
FT	#SUB	7	   5 	PHE	A	85	  81 	ILE	B	Protein	S	1
FT	#SUB	7	   5 	PHE	A	145	 141 	TYR	B	Protein	S	3
FT	#SUB	8	   6 	LYS	A	145	 141 	TYR	B	Protein	S	1
FT	#SUB	11	   9 	LEU	A	80	  76 	TYR	B	Protein	S	1
FT	#SUB	11	   9 	LEU	A	145	 141 	TYR	B	Protein	S	2
FT	#SUB	15	  13 	ARG	A	148	 144 	GLU	B	Protein	S	8
FT	#SUB	60	  58 	GLY	A	144	 140 	PHE	B	Protein	B	1
FT	#SUB	61	  59 	ILE	A	100	  96 	LYS	B	Protein	B	3
FT	#SUB	61	  59 	ILE	A	143	 139 	GLU	B	Protein	S	7
FT	#SUB	61	  59 	ILE	A	144	 140 	PHE	B	Protein	S	3
FT	#SUB	61	  59 	ILE	A	147	 143 	LEU	B	Protein	S	2
FT	#SUB	63	  61 	MET	A	100	  96 	LYS	B	Protein	S	5
FT	#SUB	63	  61 	MET	A	103	  99 	GLU	B	Protein	S	1
FT	#SUB	63	  61 	MET	A	105	 101 	GLY	B	Protein	S	2
FT	#SUB	63	  61 	MET	A	106	 102 	VAL	B	Protein	S	2
FT	#SUB	66	  64 	CYS	A	100	  96 	LYS	B	Protein	S	1
FT	#SUB	66	  64 	CYS	A	101	  97 	VAL	B	Protein	S	2
FT	#SUB	66	  64 	CYS	A	154	 150 	LEU	B	Protein	B	1
FT	#SUB	67	  65 	ARG	A	103	  99 	GLU	B	Protein	S	2
FT	#SUB	69	  67 	ILE	A	152	 148 	CYS	B	Protein	S	3
FT	#SUB	69	  67 	ILE	A	154	 150 	LEU	B	Protein	S	1
FT	#SUB	70	  68 	ALA	A	154	 150 	LEU	B	Protein	A	4
FT	#SUB	70	  68 	ALA	A	155	 151 	ILE	B	Protein	B	1
FT	#SUB	71	  69 	LEU	A	5	   1 	MET	B	Protein	A	2
FT	#SUB	73	  71 	ARG	A	13	   9 	SER	B	Protein	S	1
FT	#SUB	73	  71 	ARG	A	17	  13 	GLN	B	Protein	S	5
FT	#SUB	73	  71 	ARG	A	151	 147 	ASP	B	Protein	S	6
FT	#SUB	73	  71 	ARG	A	152	 148 	CYS	B	Protein	S	2
FT	#SUB	73	  71 	ARG	A	153	 149 	CYS	B	Protein	S	3
FT	#SUB	74	  72 	GLU	A	8	   4 	ASN	B	Protein	B	1
FT	#SUB	74	  72 	GLU	A	12	   8 	SER	B	Protein	S	3
FT	#SUB	74	  72 	GLU	A	13	   9 	SER	B	Protein	S	8
FT	#SUB	74	  72 	GLU	A	155	 151 	ILE	B	Protein	S	1
FT	#SUB	75	  73 	LEU	A	5	   1 	MET	B	Protein	S	2
FT	#SUB	86	  84 	VAL	A	152	 148 	CYS	B	Protein	S	3
FT	#SUB	88	  86 	LEU	A	144	 140 	PHE	B	Protein	S	3
FT	#SUB	88	  86 	LEU	A	147	 143 	LEU	B	Protein	S	3
FT	#SUB	88	  86 	LEU	A	148	 144 	GLU	B	Protein	S	1
FT	#SUB	89	  87 	SER	A	144	 140 	PHE	B	Protein	B	1
FT	#SUB	90	  88 	HIS	A	144	 140 	PHE	B	Protein	S	2
FT	#SUB	90	  88 	HIS	A	148	 144 	GLU	B	Protein	S	2
FT	#SUB	93	  91 	ARG	A	140	 136 	LEU	B	Protein	S	5
FT	#SUB	93	  91 	ARG	A	144	 140 	PHE	B	Protein	A	7
FT	#SUB	147	 145 	ASN	A	4	   0 	ALA	B	Protein	B	2
FT	#SUB	147	 145 	ASN	A	5	   1 	MET	B	Protein	A	4
FT	#SUB	147	 145 	ASN	A	8	   4 	ASN	B	Protein	S	3
FT	#SUB	148	 146 	TRP	A	3	  -1 	LYS	B	Protein	S	5
FT	#SUB	148	 146 	TRP	A	4	   0 	ALA	B	Protein	B	2
FT	#SUB	149	 147 	VAL	A	5	   1 	MET	B	Protein	S	1
FT	#HET	37	  35 	VAL	A	1	501 	0ST	A	S	1
FT	#HET	54	  52 	LYS	A	1	501 	0ST	A	S	2
FT	#HET	64	  62 	SER	A	1	501 	0ST	A	A	4
FT	#HET	67	  65 	ARG	A	1	501 	0ST	A	S	5
FT	#HET	68	  66 	GLU	A	1	501 	0ST	A	A	15
FT	#HET	72	  70 	LEU	A	1	501 	0ST	A	S	1
FT	#HET	75	  73 	LEU	A	1	501 	0ST	A	S	1
FT	#HET	81	  79 	ILE	A	1	501 	0ST	A	S	2
FT	#HET	99	  97 	PHE	A	1	501 	0ST	A	S	3
FT	#HET	151	 149 	HIS	A	1	501 	0ST	A	S	1
FT	#HET	173	 171 	ILE	A	1	501 	0ST	A	A	2
FT	#HET	174	 172 	ALA	A	1	501 	0ST	A	A	4
FT	#HET	175	 173 	ASP	A	1	501 	0ST	A	A	21
FT	#HET	176	 174 	MET	A	1	501 	0ST	A	A	5
FT	DISORDER	1	1
FT	DISORDER	119	124
FT	DISORDER	177	196
FT	DISORDER	240	246
FT	DISORDER	362	405
CC	SEQUENCE	327 AA (ATOM);
CC	KMDYDFKVKL SSERERVEDL FEYEGCKVGR GTYGHVYKAK RKDGKDDKDY ALKQIEGTGI
CC	SMSACREIAL LRELKHPNVI SLQKVFLSHA DRKVWLLFDY AEHDLWHIIK FHRASKALPR
CC	GMVKSLLYQI LDGIHYLHAN WVLHRDLKPA NILVMGEGPE RGRVKIADMV TFWYRAPELL
CC	LGARHYTKAI DIWAIGCIFA ELLTSEPIFH CRNPYHHDQL DRIFNVMGFP ADKDWEDIKK
CC	MPEHSTLMKD FRRNTYTNCS LIKYMEKHKV KPDSKAFHLL QKLLTMDPIK RITSEQAMQD
CC	PYFLEDPLPT SDVFAGCQIP YPKREFL
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES DKMDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKD
CC	ATOM   -KMDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKD
CC	        *************************************************
CC	SEQRES YALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFD
CC	ATOM   YALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFD
CC	       **************************************************
CC	SEQRES YAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVL
CC	ATOM   YAEHDLWHIIKFHRASKA------LPRGMVKSLLYQILDGIHYLHANWVL
CC	       ******************      **************************
CC	SEQRES HRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFW
CC	ATOM   HRDLKPANILVMGEGPERGRVKIADM--------------------VTFW
CC	       **************************                    ****
CC	SEQRES YRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYH
CC	ATOM   YRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCR-------NPYH
CC	       ***************************************       ****
CC	SEQRES HDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYME
CC	ATOM   HDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYME
CC	       **************************************************
CC	SEQRES KHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAG
CC	ATOM   KHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAG
CC	       **************************************************
CC	SEQRES CQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQG
CC	ATOM   CQIPYPKREFL---------------------------------------
CC	       ***********                                       
CC	SEQRES PPLKK
CC	ATOM   -----
CC	            
SQ	SEQUENCE	405 AA;      MW;         CN;
	DKMDYDFKVK LSSERERVED LFEYEGCKVG RGTYGHVYKA KRKDGKDDKD YALKQIEGTG
	ISMSACREIA LLRELKHPNV ISLQKVFLSH ADRKVWLLFD YAEHDLWHII KFHRASKANK
	KPVQLPRGMV KSLLYQILDG IHYLHANWVL HRDLKPANIL VMGEGPERGR VKIADMGFAR
	LFNSPLKPLA DLDPVVVTFW YRAPELLLGA RHYTKAIDIW AIGCIFAELL TSEPIFHCRQ
	EDIKTSNPYH HDQLDRIFNV MGFPADKDWE DIKKMPEHST LMKDFRRNTY TNCSLIKYME
	KHKVKPDSKA FHLLQKLLTM DPIKRITSEQ AMQDPYFLED PLPTSDVFAG CQIPYPKREF
	LTEEEPDDKG DKKNQQQQQG NNHTNGTGHP GNQDSSHTQG PPLKK
//
ID	4F70B	STANDARD;	PRT;	287	AA.
DT	CONVERTED FROM PDB (SEQRES) 4F70
DE	Cyclin-C
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	3.000
CC	R-Factor	0.204
FT	#SUB	3	  -1 	LYS	B	148	 146 	TRP	A	Protein	A	5
FT	#SUB	4	   0 	ALA	B	147	 145 	ASN	A	Protein	B	2
FT	#SUB	4	   0 	ALA	B	148	 146 	TRP	A	Protein	A	2
FT	#SUB	5	   1 	MET	B	71	  69 	LEU	A	Protein	S	2
FT	#SUB	5	   1 	MET	B	75	  73 	LEU	A	Protein	S	2
FT	#SUB	5	   1 	MET	B	147	 145 	ASN	A	Protein	A	4
FT	#SUB	5	   1 	MET	B	149	 147 	VAL	A	Protein	S	1
FT	#SUB	8	   4 	ASN	B	74	  72 	GLU	A	Protein	S	1
FT	#SUB	8	   4 	ASN	B	147	 145 	ASN	A	Protein	S	3
FT	#SUB	12	   8 	SER	B	74	  72 	GLU	A	Protein	A	3
FT	#SUB	13	   9 	SER	B	73	  71 	ARG	A	Protein	S	1
FT	#SUB	13	   9 	SER	B	74	  72 	GLU	A	Protein	A	8
FT	#SUB	17	  13 	GLN	B	73	  71 	ARG	A	Protein	S	5
FT	#SUB	80	  76 	TYR	B	7	   5 	PHE	A	Protein	S	4
FT	#SUB	80	  76 	TYR	B	11	   9 	LEU	A	Protein	S	1
FT	#SUB	83	  79 	LYS	B	4	   2 	ASP	A	Protein	A	2
FT	#SUB	84	  80 	SER	B	3	   1 	MET	A	Protein	B	3
FT	#SUB	84	  80 	SER	B	4	   2 	ASP	A	Protein	B	3
FT	#SUB	84	  80 	SER	B	7	   5 	PHE	A	Protein	A	4
FT	#SUB	85	  81 	ILE	B	7	   5 	PHE	A	Protein	S	1
FT	#SUB	100	  96 	LYS	B	61	  59 	ILE	A	Protein	S	3
FT	#SUB	100	  96 	LYS	B	63	  61 	MET	A	Protein	A	5
FT	#SUB	100	  96 	LYS	B	66	  64 	CYS	A	Protein	S	1
FT	#SUB	101	  97 	VAL	B	66	  64 	CYS	A	Protein	A	2
FT	#SUB	103	  99 	GLU	B	63	  61 	MET	A	Protein	B	1
FT	#SUB	103	  99 	GLU	B	67	  65 	ARG	A	Protein	S	2
FT	#SUB	105	 101 	GLY	B	63	  61 	MET	A	Protein	B	2
FT	#SUB	106	 102 	VAL	B	63	  61 	MET	A	Protein	S	2
FT	#SUB	134	 130 	TYR	B	2	   0 	LYS	A	Protein	S	1
FT	#SUB	140	 136 	LEU	B	93	  91 	ARG	A	Protein	A	5
FT	#SUB	143	 139 	GLU	B	61	  59 	ILE	A	Protein	A	7
FT	#SUB	144	 140 	PHE	B	60	  58 	GLY	A	Protein	S	1
FT	#SUB	144	 140 	PHE	B	61	  59 	ILE	A	Protein	S	3
FT	#SUB	144	 140 	PHE	B	88	  86 	LEU	A	Protein	A	3
FT	#SUB	144	 140 	PHE	B	89	  87 	SER	A	Protein	S	1
FT	#SUB	144	 140 	PHE	B	90	  88 	HIS	A	Protein	S	2
FT	#SUB	144	 140 	PHE	B	93	  91 	ARG	A	Protein	S	7
FT	#SUB	145	 141 	TYR	B	3	   1 	MET	A	Protein	S	5
FT	#SUB	145	 141 	TYR	B	7	   5 	PHE	A	Protein	S	3
FT	#SUB	145	 141 	TYR	B	8	   6 	LYS	A	Protein	S	1
FT	#SUB	145	 141 	TYR	B	11	   9 	LEU	A	Protein	S	2
FT	#SUB	147	 143 	LEU	B	61	  59 	ILE	A	Protein	S	2
FT	#SUB	147	 143 	LEU	B	88	  86 	LEU	A	Protein	S	3
FT	#SUB	148	 144 	GLU	B	15	  13 	ARG	A	Protein	S	8
FT	#SUB	148	 144 	GLU	B	88	  86 	LEU	A	Protein	B	1
FT	#SUB	148	 144 	GLU	B	90	  88 	HIS	A	Protein	S	2
FT	#SUB	151	 147 	ASP	B	73	  71 	ARG	A	Protein	A	6
FT	#SUB	152	 148 	CYS	B	69	  67 	ILE	A	Protein	A	3
FT	#SUB	152	 148 	CYS	B	73	  71 	ARG	A	Protein	B	2
FT	#SUB	152	 148 	CYS	B	86	  84 	VAL	A	Protein	S	3
FT	#SUB	153	 149 	CYS	B	73	  71 	ARG	A	Protein	S	3
FT	#SUB	154	 150 	LEU	B	66	  64 	CYS	A	Protein	S	1
FT	#SUB	154	 150 	LEU	B	69	  67 	ILE	A	Protein	S	1
FT	#SUB	154	 150 	LEU	B	70	  68 	ALA	A	Protein	S	4
FT	#SUB	155	 151 	ILE	B	70	  68 	ALA	A	Protein	S	1
FT	#SUB	155	 151 	ILE	B	74	  72 	GLU	A	Protein	S	1
FT	#SUB	264	 260 	PRO	B	2	   0 	LYS	A	Protein	S	1
FT	#SUB	264	 260 	PRO	B	3	   1 	MET	A	Protein	S	1
FT	#SUB	264	 260 	PRO	B	4	   2 	ASP	A	Protein	A	4
FT	#SUB	265	 261 	LYS	B	3	   1 	MET	A	Protein	B	1
FT	#SUB	265	 261 	LYS	B	4	   2 	ASP	A	Protein	A	6
FT	#SUB	265	 261 	LYS	B	5	   3 	TYR	A	Protein	B	3
FT	#SUB	265	 261 	LYS	B	6	   4 	ASP	A	Protein	S	3
FT	#SUB	267	 263 	PRO	B	5	   3 	TYR	A	Protein	S	1
FT	#SUB	268	 264 	PRO	B	5	   3 	TYR	A	Protein	S	1
FT	#HET	41	  37 	TYR	B	2	301 	EDO	B	S	2
FT	#HET	45	  41 	GLN	B	2	301 	EDO	B	S	5
FT	#HET	73	  69 	PHE	B	2	301 	EDO	B	S	1
FT	#HET	74	  70 	LYS	B	2	301 	EDO	B	A	4
FT	#HET	78	  74 	ALA	B	2	301 	EDO	B	B	1
FT	DISORDER	1	2
FT	DISORDER	269	287
CC	SEQUENCE	266 AA (ATOM);
CC	KAMAGNFWQS SHYLQWILDK QDLLKERQKD LKFLSEEEYW KLQIFFTNVI QALGEHLKLR
CC	QQVIATATVY FKRFYARYSL KSIDPVLMAP TCVFLASKVE EFGVVSNTRL IAAATSVLKT
CC	RFSYAFPKEF PYRMNHILEC EFYLLELMDC CLIVYHPYRP LLQYVQDMGQ EDMLLPLAWR
CC	IVNDTYRTDL CLLYPPFMIA LACLHVACVV QQKDARQWFA ELSVDMEKIL EIIRVILKLY
CC	EQWKNFDERK EMATILSKMP KPKPPP
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES DDKAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTN
CC	ATOM   --KAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTN
CC	         ************************************************
CC	SEQRES VIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASK
CC	ATOM   VIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASK
CC	       **************************************************
CC	SEQRES VEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELM
CC	ATOM   VEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELM
CC	       **************************************************
CC	SEQRES DCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFM
CC	ATOM   DCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFM
CC	       **************************************************
CC	SEQRES IALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDE
CC	ATOM   IALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDE
CC	       **************************************************
CC	SEQRES RKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
CC	ATOM   RKEMATILSKMPKPKPPP-------------------
CC	       ******************                   
SQ	SEQUENCE	287 AA;      MW;         CN;
	DDKAMAGNFW QSSHYLQWIL DKQDLLKERQ KDLKFLSEEE YWKLQIFFTN VIQALGEHLK
	LRQQVIATAT VYFKRFYARY SLKSIDPVLM APTCVFLASK VEEFGVVSNT RLIAAATSVL
	KTRFSYAFPK EFPYRMNHIL ECEFYLLELM DCCLIVYHPY RPLLQYVQDM GQEDMLLPLA
	WRIVNDTYRT DLCLLYPPFM IALACLHVAC VVQQKDARQW FAELSVDMEK ILEIIRVILK
	LYEQWKNFDE RKEMATILSK MPKPKPPPNS EGEQGPNGSQ NSSYSQS
//