ID 4F6WA STANDARD; PRT; 405 AA. DT CONVERTED FROM PDB (SEQRES) 4F6W DE Cyclin-dependent kinase 8 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.390 CC R-Factor 0.193 FT #SUB 3 1 MET A 84 80 SER B Protein A 4 FT #SUB 3 1 MET A 145 141 TYR B Protein S 5 FT #SUB 3 1 MET A 264 260 PRO B Protein B 2 FT #SUB 3 1 MET A 265 261 LYS B Protein B 1 FT #SUB 4 2 ASP A 83 79 LYS B Protein A 5 FT #SUB 4 2 ASP A 84 80 SER B Protein A 5 FT #SUB 4 2 ASP A 264 260 PRO B Protein A 3 FT #SUB 4 2 ASP A 265 261 LYS B Protein A 6 FT #SUB 5 3 TYR A 265 261 LYS B Protein A 3 FT #SUB 5 3 TYR A 266 262 PRO B Protein S 2 FT #SUB 5 3 TYR A 267 263 PRO B Protein S 1 FT #SUB 5 3 TYR A 268 264 PRO B Protein S 2 FT #SUB 6 4 ASP A 265 261 LYS B Protein S 1 FT #SUB 7 5 PHE A 76 72 PHE B Protein S 1 FT #SUB 7 5 PHE A 80 76 TYR B Protein S 6 FT #SUB 7 5 PHE A 84 80 SER B Protein S 5 FT #SUB 7 5 PHE A 145 141 TYR B Protein S 1 FT #SUB 8 6 LYS A 145 141 TYR B Protein S 1 FT #SUB 11 9 LEU A 80 76 TYR B Protein S 1 FT #SUB 11 9 LEU A 145 141 TYR B Protein S 2 FT #SUB 15 13 ARG A 148 144 GLU B Protein S 6 FT #SUB 60 58 GLY A 144 140 PHE B Protein B 1 FT #SUB 61 59 ILE A 100 96 LYS B Protein A 5 FT #SUB 61 59 ILE A 143 139 GLU B Protein S 5 FT #SUB 61 59 ILE A 144 140 PHE B Protein S 2 FT #SUB 61 59 ILE A 147 143 LEU B Protein S 1 FT #SUB 63 61 MET A 100 96 LYS B Protein S 5 FT #SUB 63 61 MET A 106 102 VAL B Protein S 2 FT #SUB 66 64 CYS A 100 96 LYS B Protein S 2 FT #SUB 66 64 CYS A 101 97 VAL B Protein S 3 FT #SUB 66 64 CYS A 154 150 LEU B Protein B 1 FT #SUB 69 67 ILE A 152 148 CYS B Protein S 1 FT #SUB 69 67 ILE A 154 150 LEU B Protein S 1 FT #SUB 70 68 ALA A 154 150 LEU B Protein A 4 FT #SUB 70 68 ALA A 155 151 ILE B Protein B 2 FT #SUB 73 71 ARG A 17 13 GLN B Protein S 5 FT #SUB 73 71 ARG A 151 147 ASP B Protein S 6 FT #SUB 73 71 ARG A 152 148 CYS B Protein S 4 FT #SUB 73 71 ARG A 153 149 CYS B Protein S 3 FT #SUB 74 72 GLU A 5 1 MET B Protein S 1 FT #SUB 74 72 GLU A 12 8 SER B Protein S 3 FT #SUB 74 72 GLU A 13 9 SER B Protein S 10 FT #SUB 74 72 GLU A 155 151 ILE B Protein S 1 FT #SUB 75 73 LEU A 5 1 MET B Protein S 2 FT #SUB 86 84 VAL A 152 148 CYS B Protein S 2 FT #SUB 88 86 LEU A 144 140 PHE B Protein S 3 FT #SUB 88 86 LEU A 147 143 LEU B Protein S 2 FT #SUB 88 86 LEU A 148 144 GLU B Protein S 1 FT #SUB 89 87 SER A 144 140 PHE B Protein B 1 FT #SUB 90 88 HIS A 144 140 PHE B Protein S 1 FT #SUB 90 88 HIS A 145 141 TYR B Protein S 4 FT #SUB 90 88 HIS A 148 144 GLU B Protein S 5 FT #SUB 93 91 ARG A 140 136 LEU B Protein S 6 FT #SUB 93 91 ARG A 144 140 PHE B Protein A 6 FT #SUB 147 145 ASN A 4 0 ALA B Protein B 2 FT #SUB 147 145 ASN A 5 1 MET B Protein A 6 FT #SUB 147 145 ASN A 8 4 ASN B Protein S 3 FT #SUB 148 146 TRP A 2 -2 ASP B Protein S 9 FT #SUB 148 146 TRP A 3 -1 LYS B Protein S 2 FT #SUB 148 146 TRP A 4 0 ALA B Protein B 1 FT #SUB 149 147 VAL A 5 1 MET B Protein S 1 FT #HET 11 9 LEU A 12 304 EDO B S 3 FT #HET 15 13 ARG A 6 506 EDO A S 2 FT #HET 16 14 GLU A 6 506 EDO A B 3 FT #HET 19 17 GLU A 8 508 FMT A B 1 FT #HET 22 20 PHE A 8 508 FMT A B 2 FT #HET 23 21 GLU A 8 508 FMT A A 4 FT #HET 24 22 TYR A 8 508 FMT A A 5 FT #HET 25 23 GLU A 8 508 FMT A A 5 FT #HET 29 27 VAL A 1 501 0SS A A 4 FT #HET 34 32 TYR A 1 501 0SS A S 10 FT #HET 37 35 VAL A 1 501 0SS A S 1 FT #HET 59 57 THR A 13 305 EDO B B 1 FT #HET 61 59 ILE A 13 305 EDO B B 3 FT #HET 64 62 SER A 1 501 0SS A A 4 FT #HET 68 66 GLU A 1 501 0SS A A 17 FT #HET 72 70 LEU A 1 501 0SS A S 3 FT #HET 75 73 LEU A 1 501 0SS A S 1 FT #HET 80 78 VAL A 1 501 0SS A S 1 FT #HET 81 79 ILE A 1 501 0SS A S 3 FT #HET 85 83 LYS A 6 506 EDO A S 3 FT #HET 85 83 LYS A 7 507 FMT A A 2 FT #HET 86 84 VAL A 6 506 EDO A B 3 FT #HET 86 84 VAL A 7 507 FMT A A 5 FT #HET 87 85 PHE A 6 506 EDO A A 4 FT #HET 88 86 LEU A 6 506 EDO A B 1 FT #HET 99 97 PHE A 1 501 0SS A S 8 FT #HET 101 99 TYR A 1 501 0SS A S 1 FT #HET 107 105 TRP A 1 501 0SS A S 4 FT #HET 108 106 HIS A 1 501 0SS A S 1 FT #HET 126 124 PRO A 5 505 EDO A S 2 FT #HET 128 126 GLY A 5 505 EDO A B 7 FT #HET 129 127 MET A 5 505 EDO A B 1 FT #HET 135 133 TYR A 3 503 EDO A S 1 FT #HET 136 134 GLN A 3 503 EDO A S 1 FT #HET 151 149 HIS A 1 501 0SS A S 2 FT #HET 155 153 LYS A 2 502 DMS A S 1 FT #HET 157 155 ALA A 2 502 DMS A S 2 FT #HET 160 158 LEU A 1 501 0SS A S 1 FT #HET 173 171 ILE A 1 501 0SS A A 2 FT #HET 174 172 ALA A 1 501 0SS A A 5 FT #HET 175 173 ASP A 1 501 0SS A A 17 FT #HET 176 174 MET A 1 501 0SS A A 6 FT #HET 177 175 GLY A 1 501 0SS A B 1 FT #HET 309 307 LYS A 4 504 EDO A S 1 FT #HET 335 333 PRO A 4 504 EDO A B 1 FT #HET 338 336 LEU A 4 504 EDO A S 2 FT #HET 344 342 THR A 3 503 EDO A B 2 FT #HET 345 343 SER A 3 503 EDO A A 2 FT #HET 358 356 ARG A 1 501 0SS A S 14 FT DISORDER 1 2 FT DISORDER 118 122 FT DISORDER 180 197 FT DISORDER 241 246 FT DISORDER 362 405 CC SEQUENCE 330 AA (ATOM); CC MDYDFKVKLS SERERVEDLF EYEGCKVGRG TYGHVYKAKR KDGKDDKDYA LKQIEGTGIS CC MSACREIALL RELKHPNVIS LQKVFLSHAD RKVWLLFDYA EHDLWHIIKF HRASKVQLPR CC GMVKSLLYQI LDGIHYLHAN WVLHRDLKPA NILVMGEGPE RGRVKIADMG FATFWYRAPE CC LLLGARHYTK AIDIWAIGCI FAELLTSEPI FHCRQNPYHH DQLDRIFNVM GFPADKDWED CC IKKMPEHSTL MKDFRRNTYT NCSLIKYMEK HKVKPDSKAF HLLQKLLTMD PIKRITSEQA CC MQDPYFLEDP LPTSDVFAGC QIPYPKREFL CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES DKMDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKD CC ATOM --MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKD CC ************************************************ CC SEQRES YALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFD CC ATOM YALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFD CC ************************************************** CC SEQRES YAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVL CC ATOM YAEHDLWHIIKFHRASK-----VQLPRGMVKSLLYQILDGIHYLHANWVL CC ***************** **************************** CC SEQRES HRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFW CC ATOM HRDLKPANILVMGEGPERGRVKIADMGFA------------------TFW CC ***************************** *** CC SEQRES YRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYH CC ATOM YRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQ------NPYH CC **************************************** **** CC SEQRES HDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYME CC ATOM HDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYME CC ************************************************** CC SEQRES KHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAG CC ATOM KHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAG CC ************************************************** CC SEQRES CQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQG CC ATOM CQIPYPKREFL--------------------------------------- CC *********** CC SEQRES PPLKK CC ATOM ----- CC SQ SEQUENCE 405 AA; MW; CN; DKMDYDFKVK LSSERERVED LFEYEGCKVG RGTYGHVYKA KRKDGKDDKD YALKQIEGTG ISMSACREIA LLRELKHPNV ISLQKVFLSH ADRKVWLLFD YAEHDLWHII KFHRASKANK KPVQLPRGMV KSLLYQILDG IHYLHANWVL HRDLKPANIL VMGEGPERGR VKIADMGFAR LFNSPLKPLA DLDPVVVTFW YRAPELLLGA RHYTKAIDIW AIGCIFAELL TSEPIFHCRQ EDIKTSNPYH HDQLDRIFNV MGFPADKDWE DIKKMPEHST LMKDFRRNTY TNCSLIKYME KHKVKPDSKA FHLLQKLLTM DPIKRITSEQ AMQDPYFLED PLPTSDVFAG CQIPYPKREF LTEEEPDDKG DKKNQQQQQG NNHTNGTGHP GNQDSSHTQG PPLKK // ID 4F6WB STANDARD; PRT; 287 AA. DT CONVERTED FROM PDB (SEQRES) 4F6W DE Cyclin-C OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.390 CC R-Factor 0.193 FT #SUB 2 -2 ASP B 148 146 TRP A Protein A 9 FT #SUB 3 -1 LYS B 148 146 TRP A Protein B 2 FT #SUB 4 0 ALA B 147 145 ASN A Protein B 2 FT #SUB 4 0 ALA B 148 146 TRP A Protein B 1 FT #SUB 5 1 MET B 74 72 GLU A Protein S 1 FT #SUB 5 1 MET B 75 73 LEU A Protein S 2 FT #SUB 5 1 MET B 147 145 ASN A Protein A 6 FT #SUB 5 1 MET B 149 147 VAL A Protein S 1 FT #SUB 8 4 ASN B 147 145 ASN A Protein S 3 FT #SUB 12 8 SER B 74 72 GLU A Protein A 3 FT #SUB 13 9 SER B 74 72 GLU A Protein A 10 FT #SUB 17 13 GLN B 73 71 ARG A Protein S 5 FT #SUB 76 72 PHE B 7 5 PHE A Protein S 1 FT #SUB 80 76 TYR B 7 5 PHE A Protein S 6 FT #SUB 80 76 TYR B 11 9 LEU A Protein S 1 FT #SUB 83 79 LYS B 4 2 ASP A Protein A 5 FT #SUB 84 80 SER B 3 1 MET A Protein B 4 FT #SUB 84 80 SER B 4 2 ASP A Protein B 5 FT #SUB 84 80 SER B 7 5 PHE A Protein A 5 FT #SUB 100 96 LYS B 61 59 ILE A Protein S 5 FT #SUB 100 96 LYS B 63 61 MET A Protein A 5 FT #SUB 100 96 LYS B 66 64 CYS A Protein A 2 FT #SUB 101 97 VAL B 66 64 CYS A Protein A 3 FT #SUB 106 102 VAL B 63 61 MET A Protein S 2 FT #SUB 140 136 LEU B 93 91 ARG A Protein A 6 FT #SUB 143 139 GLU B 61 59 ILE A Protein S 5 FT #SUB 144 140 PHE B 60 58 GLY A Protein S 1 FT #SUB 144 140 PHE B 61 59 ILE A Protein S 2 FT #SUB 144 140 PHE B 88 86 LEU A Protein A 3 FT #SUB 144 140 PHE B 89 87 SER A Protein S 1 FT #SUB 144 140 PHE B 90 88 HIS A Protein S 1 FT #SUB 144 140 PHE B 93 91 ARG A Protein S 6 FT #SUB 145 141 TYR B 3 1 MET A Protein S 5 FT #SUB 145 141 TYR B 7 5 PHE A Protein S 1 FT #SUB 145 141 TYR B 8 6 LYS A Protein S 1 FT #SUB 145 141 TYR B 11 9 LEU A Protein S 2 FT #SUB 145 141 TYR B 90 88 HIS A Protein S 4 FT #SUB 147 143 LEU B 61 59 ILE A Protein S 1 FT #SUB 147 143 LEU B 88 86 LEU A Protein S 2 FT #SUB 148 144 GLU B 15 13 ARG A Protein S 6 FT #SUB 148 144 GLU B 88 86 LEU A Protein S 1 FT #SUB 148 144 GLU B 90 88 HIS A Protein S 5 FT #SUB 151 147 ASP B 73 71 ARG A Protein A 6 FT #SUB 152 148 CYS B 69 67 ILE A Protein S 1 FT #SUB 152 148 CYS B 73 71 ARG A Protein B 4 FT #SUB 152 148 CYS B 86 84 VAL A Protein S 2 FT #SUB 153 149 CYS B 73 71 ARG A Protein S 3 FT #SUB 154 150 LEU B 66 64 CYS A Protein S 1 FT #SUB 154 150 LEU B 69 67 ILE A Protein S 1 FT #SUB 154 150 LEU B 70 68 ALA A Protein S 4 FT #SUB 155 151 ILE B 70 68 ALA A Protein S 2 FT #SUB 155 151 ILE B 74 72 GLU A Protein S 1 FT #SUB 264 260 PRO B 3 1 MET A Protein S 2 FT #SUB 264 260 PRO B 4 2 ASP A Protein A 3 FT #SUB 265 261 LYS B 3 1 MET A Protein B 1 FT #SUB 265 261 LYS B 4 2 ASP A Protein A 6 FT #SUB 265 261 LYS B 5 3 TYR A Protein B 3 FT #SUB 265 261 LYS B 6 4 ASP A Protein S 1 FT #SUB 266 262 PRO B 5 3 TYR A Protein B 2 FT #SUB 267 263 PRO B 5 3 TYR A Protein B 1 FT #SUB 268 264 PRO B 5 3 TYR A Protein S 2 FT #HET 4 0 ALA B 9 301 EDO B B 3 FT #HET 5 1 MET B 9 301 EDO B B 2 FT #HET 6 2 ALA B 9 301 EDO B B 2 FT #HET 45 41 GLN B 15 307 FMT B A 6 FT #HET 49 45 THR B 15 307 FMT B A 6 FT #HET 50 46 ASN B 14 306 FMT B S 2 FT #HET 53 49 GLN B 10 302 EDO B S 1 FT #HET 57 53 GLU B 10 302 EDO B A 3 FT #HET 61 57 LEU B 10 302 EDO B B 5 FT #HET 63 59 GLN B 10 302 EDO B S 2 FT #HET 70 66 THR B 15 307 FMT B S 1 FT #HET 73 69 PHE B 15 307 FMT B S 4 FT #HET 74 70 LYS B 15 307 FMT B S 7 FT #HET 80 76 TYR B 12 304 EDO B S 6 FT #HET 96 92 PHE B 13 305 EDO B S 2 FT #HET 100 96 LYS B 13 305 EDO B S 3 FT #HET 106 102 VAL B 13 305 EDO B S 1 FT #HET 121 117 LYS B 16 308 FMT B B 1 FT #HET 122 118 THR B 16 308 FMT B B 4 FT #HET 123 119 ARG B 16 308 FMT B B 9 FT #HET 124 120 PHE B 16 308 FMT B B 4 FT #HET 125 121 SER B 16 308 FMT B A 6 FT #HET 145 141 TYR B 12 304 EDO B A 6 FT #HET 148 144 GLU B 12 304 EDO B A 4 FT #HET 149 145 LEU B 12 304 EDO B A 10 FT #HET 151 147 ASP B 7 507 FMT A S 2 FT #HET 156 152 VAL B 9 301 EDO B B 2 FT #HET 157 153 TYR B 9 301 EDO B S 4 FT #HET 165 161 GLN B 11 303 EDO B S 3 FT #HET 166 162 TYR B 11 303 EDO B S 3 FT #HET 188 184 TYR B 15 307 FMT B B 1 FT #HET 189 185 ARG B 14 306 FMT B S 8 FT #HET 199 195 PHE B 11 303 EDO B S 1 FT #HET 248 244 PHE B 14 306 FMT B S 1 FT #HET 250 246 GLU B 14 306 FMT B S 4 FT #HET 251 247 ARG B 16 308 FMT B S 2 FT DISORDER 1 1 FT DISORDER 269 287 CC SEQUENCE 267 AA (ATOM); CC DKAMAGNFWQ SSHYLQWILD KQDLLKERQK DLKFLSEEEY WKLQIFFTNV IQALGEHLKL CC RQQVIATATV YFKRFYARYS LKSIDPVLMA PTCVFLASKV EEFGVVSNTR LIAAATSVLK CC TRFSYAFPKE FPYRMNHILE CEFYLLELMD CCLIVYHPYR PLLQYVQDMG QEDMLLPLAW CC RIVNDTYRTD LCLLYPPFMI ALACLHVACV VQQKDARQWF AELSVDMEKI LEIIRVILKL CC YEQWKNFDER KEMATILSKM PKPKPPP CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES DDKAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTN CC ATOM -DKAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTN CC ************************************************* CC SEQRES VIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASK CC ATOM VIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASK CC ************************************************** CC SEQRES VEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELM CC ATOM VEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELM CC ************************************************** CC SEQRES DCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFM CC ATOM DCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFM CC ************************************************** CC SEQRES IALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDE CC ATOM IALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDE CC ************************************************** CC SEQRES RKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS CC ATOM RKEMATILSKMPKPKPPP------------------- CC ****************** SQ SEQUENCE 287 AA; MW; CN; DDKAMAGNFW QSSHYLQWIL DKQDLLKERQ KDLKFLSEEE YWKLQIFFTN VIQALGEHLK LRQQVIATAT VYFKRFYARY SLKSIDPVLM APTCVFLASK VEEFGVVSNT RLIAAATSVL KTRFSYAFPK EFPYRMNHIL ECEFYLLELM DCCLIVYHPY RPLLQYVQDM GQEDMLLPLA WRIVNDTYRT DLCLLYPPFM IALACLHVAC VVQQKDARQW FAELSVDMEK ILEIIRVILK LYEQWKNFDE RKEMATILSK MPKPKPPPNS EGEQGPNGSQ NSSYSQS //