ID 4F6SA STANDARD; PRT; 405 AA. DT CONVERTED FROM PDB (SEQRES) 4F6S DE Cyclin-dependent kinase 8 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.600 CC R-Factor 0.205 FT #SUB 2 0 LYS A 134 130 TYR B Protein S 1 FT #SUB 2 0 LYS A 264 260 PRO B Protein B 2 FT #SUB 3 1 MET A 84 80 SER B Protein A 2 FT #SUB 3 1 MET A 85 81 ILE B Protein S 2 FT #SUB 3 1 MET A 141 137 GLU B Protein S 1 FT #SUB 3 1 MET A 145 141 TYR B Protein S 4 FT #SUB 3 1 MET A 265 261 LYS B Protein B 1 FT #SUB 4 2 ASP A 83 79 LYS B Protein S 2 FT #SUB 4 2 ASP A 84 80 SER B Protein A 4 FT #SUB 4 2 ASP A 264 260 PRO B Protein A 3 FT #SUB 4 2 ASP A 265 261 LYS B Protein A 7 FT #SUB 5 3 TYR A 265 261 LYS B Protein A 4 FT #SUB 5 3 TYR A 266 262 PRO B Protein S 1 FT #SUB 5 3 TYR A 267 263 PRO B Protein S 4 FT #SUB 5 3 TYR A 268 264 PRO B Protein S 2 FT #SUB 6 4 ASP A 265 261 LYS B Protein S 6 FT #SUB 7 5 PHE A 80 76 TYR B Protein S 1 FT #SUB 7 5 PHE A 84 80 SER B Protein S 4 FT #SUB 7 5 PHE A 145 141 TYR B Protein S 1 FT #SUB 8 6 LYS A 145 141 TYR B Protein S 1 FT #SUB 11 9 LEU A 80 76 TYR B Protein S 1 FT #SUB 11 9 LEU A 145 141 TYR B Protein S 1 FT #SUB 15 13 ARG A 148 144 GLU B Protein S 5 FT #SUB 61 59 ILE A 100 96 LYS B Protein A 5 FT #SUB 61 59 ILE A 143 139 GLU B Protein S 5 FT #SUB 61 59 ILE A 144 140 PHE B Protein S 1 FT #SUB 61 59 ILE A 147 143 LEU B Protein S 1 FT #SUB 63 61 MET A 100 96 LYS B Protein S 5 FT #SUB 63 61 MET A 103 99 GLU B Protein S 1 FT #SUB 63 61 MET A 105 101 GLY B Protein S 2 FT #SUB 66 64 CYS A 100 96 LYS B Protein S 2 FT #SUB 66 64 CYS A 101 97 VAL B Protein S 3 FT #SUB 66 64 CYS A 154 150 LEU B Protein B 1 FT #SUB 69 67 ILE A 152 148 CYS B Protein S 2 FT #SUB 70 68 ALA A 154 150 LEU B Protein A 2 FT #SUB 70 68 ALA A 155 151 ILE B Protein A 2 FT #SUB 73 71 ARG A 17 13 GLN B Protein S 4 FT #SUB 73 71 ARG A 151 147 ASP B Protein S 3 FT #SUB 73 71 ARG A 152 148 CYS B Protein S 3 FT #SUB 73 71 ARG A 153 149 CYS B Protein S 2 FT #SUB 74 72 GLU A 12 8 SER B Protein S 3 FT #SUB 74 72 GLU A 13 9 SER B Protein S 9 FT #SUB 74 72 GLU A 155 151 ILE B Protein S 1 FT #SUB 75 73 LEU A 5 1 MET B Protein S 2 FT #SUB 86 84 VAL A 152 148 CYS B Protein S 2 FT #SUB 88 86 LEU A 144 140 PHE B Protein S 3 FT #SUB 88 86 LEU A 147 143 LEU B Protein S 1 FT #SUB 89 87 SER A 144 140 PHE B Protein B 3 FT #SUB 90 88 HIS A 144 140 PHE B Protein S 2 FT #SUB 90 88 HIS A 145 141 TYR B Protein S 3 FT #SUB 93 91 ARG A 140 136 LEU B Protein S 7 FT #SUB 93 91 ARG A 143 139 GLU B Protein S 1 FT #SUB 93 91 ARG A 144 140 PHE B Protein A 8 FT #SUB 147 145 ASN A 4 0 ALA B Protein B 2 FT #SUB 147 145 ASN A 5 1 MET B Protein A 6 FT #SUB 147 145 ASN A 8 4 ASN B Protein S 2 FT #SUB 148 146 TRP A 3 -1 LYS B Protein S 6 FT #SUB 148 146 TRP A 4 0 ALA B Protein B 1 FT #HET 34 32 TYR A 1 501 0SQ A S 5 FT #HET 34 32 TYR A 4 504 FMT A S 1 FT #HET 37 35 VAL A 2 502 EDO A S 1 FT #HET 52 50 ALA A 2 502 EDO A S 2 FT #HET 54 52 LYS A 1 501 0SQ A S 1 FT #HET 64 62 SER A 1 501 0SQ A A 5 FT #HET 64 62 SER A 4 504 FMT A S 1 FT #HET 67 65 ARG A 1 501 0SQ A S 1 FT #HET 67 65 ARG A 4 504 FMT A S 7 FT #HET 68 66 GLU A 1 501 0SQ A A 19 FT #HET 73 71 ARG A 5 505 FMT A A 5 FT #HET 74 72 GLU A 5 505 FMT A B 2 FT #HET 75 73 LEU A 1 501 0SQ A S 1 FT #HET 81 79 ILE A 1 501 0SQ A S 3 FT #HET 81 79 ILE A 2 502 EDO A S 1 FT #HET 81 79 ILE A 6 506 FMT A A 2 FT #HET 82 80 SER A 6 506 FMT A A 6 FT #HET 99 97 PHE A 1 501 0SQ A S 2 FT #HET 100 98 ASP A 2 502 EDO A B 1 FT #HET 100 98 ASP A 6 506 FMT A S 5 FT #HET 102 100 ALA A 2 502 EDO A B 3 FT #HET 151 149 HIS A 1 501 0SQ A S 2 FT #HET 152 150 ARG A 3 503 FMT A S 3 FT #HET 152 150 ARG A 4 504 FMT A S 3 FT #HET 160 158 LEU A 2 502 EDO A S 1 FT #HET 167 165 GLU A 6 506 FMT A S 1 FT #HET 172 170 LYS A 6 506 FMT A S 3 FT #HET 173 171 ILE A 1 501 0SQ A S 1 FT #HET 174 172 ALA A 1 501 0SQ A A 4 FT #HET 175 173 ASP A 1 501 0SQ A A 17 FT #HET 212 210 HIS A 3 503 FMT A A 2 FT #HET 213 211 TYR A 3 503 FMT A A 3 FT DISORDER 1 1 FT DISORDER 117 124 FT DISORDER 180 196 FT DISORDER 240 246 FT DISORDER 362 405 CC SEQUENCE 328 AA (ATOM); CC KMDYDFKVKL SSERERVEDL FEYEGCKVGR GTYGHVYKAK RKDGKDDKDY ALKQIEGTGI CC SMSACREIAL LRELKHPNVI SLQKVFLSHA DRKVWLLFDY AEHDLWHIIK FHRASLPRGM CC VKSLLYQILD GIHYLHANWV LHRDLKPANI LVMGEGPERG RVKIADMGFA VTFWYRAPEL CC LLGARHYTKA IDIWAIGCIF AELLTSEPIF HCRNPYHHDQ LDRIFNVMGF PADKDWEDIK CC KMPEHSTLMK DFRRNTYTNC SLIKYMEKHK VKPDSKAFHL LQKLLTMDPI KRITSEQAMQ CC DPYFLEDPLP TSDVFAGCQI PYPKREFL CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES DKMDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKD CC ATOM -KMDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKD CC ************************************************* CC SEQRES YALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFD CC ATOM YALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFD CC ************************************************** CC SEQRES YAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVL CC ATOM YAEHDLWHIIKFHRAS--------LPRGMVKSLLYQILDGIHYLHANWVL CC **************** ************************** CC SEQRES HRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFW CC ATOM HRDLKPANILVMGEGPERGRVKIADMGFA-----------------VTFW CC ***************************** **** CC SEQRES YRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYH CC ATOM YRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCR-------NPYH CC *************************************** **** CC SEQRES HDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYME CC ATOM HDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYME CC ************************************************** CC SEQRES KHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAG CC ATOM KHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAG CC ************************************************** CC SEQRES CQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQG CC ATOM CQIPYPKREFL--------------------------------------- CC *********** CC SEQRES PPLKK CC ATOM ----- CC SQ SEQUENCE 405 AA; MW; CN; DKMDYDFKVK LSSERERVED LFEYEGCKVG RGTYGHVYKA KRKDGKDDKD YALKQIEGTG ISMSACREIA LLRELKHPNV ISLQKVFLSH ADRKVWLLFD YAEHDLWHII KFHRASKANK KPVQLPRGMV KSLLYQILDG IHYLHANWVL HRDLKPANIL VMGEGPERGR VKIADMGFAR LFNSPLKPLA DLDPVVVTFW YRAPELLLGA RHYTKAIDIW AIGCIFAELL TSEPIFHCRQ EDIKTSNPYH HDQLDRIFNV MGFPADKDWE DIKKMPEHST LMKDFRRNTY TNCSLIKYME KHKVKPDSKA FHLLQKLLTM DPIKRITSEQ AMQDPYFLED PLPTSDVFAG CQIPYPKREF LTEEEPDDKG DKKNQQQQQG NNHTNGTGHP GNQDSSHTQG PPLKK // ID 4F6SB STANDARD; PRT; 287 AA. DT CONVERTED FROM PDB (SEQRES) 4F6S DE Cyclin-C OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.600 CC R-Factor 0.205 FT #SUB 3 -1 LYS B 148 146 TRP A Protein B 6 FT #SUB 4 0 ALA B 147 145 ASN A Protein B 2 FT #SUB 4 0 ALA B 148 146 TRP A Protein B 1 FT #SUB 5 1 MET B 75 73 LEU A Protein S 2 FT #SUB 5 1 MET B 147 145 ASN A Protein A 6 FT #SUB 8 4 ASN B 147 145 ASN A Protein S 2 FT #SUB 12 8 SER B 74 72 GLU A Protein A 3 FT #SUB 13 9 SER B 74 72 GLU A Protein A 9 FT #SUB 17 13 GLN B 73 71 ARG A Protein S 4 FT #SUB 80 76 TYR B 7 5 PHE A Protein S 1 FT #SUB 80 76 TYR B 11 9 LEU A Protein S 1 FT #SUB 83 79 LYS B 4 2 ASP A Protein A 2 FT #SUB 84 80 SER B 3 1 MET A Protein B 2 FT #SUB 84 80 SER B 4 2 ASP A Protein B 4 FT #SUB 84 80 SER B 7 5 PHE A Protein A 4 FT #SUB 85 81 ILE B 3 1 MET A Protein S 2 FT #SUB 100 96 LYS B 61 59 ILE A Protein S 5 FT #SUB 100 96 LYS B 63 61 MET A Protein A 5 FT #SUB 100 96 LYS B 66 64 CYS A Protein A 2 FT #SUB 101 97 VAL B 66 64 CYS A Protein A 3 FT #SUB 103 99 GLU B 63 61 MET A Protein B 1 FT #SUB 105 101 GLY B 63 61 MET A Protein B 2 FT #SUB 134 130 TYR B 2 0 LYS A Protein S 1 FT #SUB 140 136 LEU B 93 91 ARG A Protein A 7 FT #SUB 141 137 GLU B 3 1 MET A Protein S 1 FT #SUB 143 139 GLU B 61 59 ILE A Protein S 5 FT #SUB 143 139 GLU B 93 91 ARG A Protein S 1 FT #SUB 144 140 PHE B 61 59 ILE A Protein S 1 FT #SUB 144 140 PHE B 88 86 LEU A Protein A 3 FT #SUB 144 140 PHE B 89 87 SER A Protein S 3 FT #SUB 144 140 PHE B 90 88 HIS A Protein S 2 FT #SUB 144 140 PHE B 93 91 ARG A Protein S 8 FT #SUB 145 141 TYR B 3 1 MET A Protein S 4 FT #SUB 145 141 TYR B 7 5 PHE A Protein S 1 FT #SUB 145 141 TYR B 8 6 LYS A Protein S 1 FT #SUB 145 141 TYR B 11 9 LEU A Protein S 1 FT #SUB 145 141 TYR B 90 88 HIS A Protein S 3 FT #SUB 147 143 LEU B 61 59 ILE A Protein S 1 FT #SUB 147 143 LEU B 88 86 LEU A Protein S 1 FT #SUB 148 144 GLU B 15 13 ARG A Protein S 5 FT #SUB 151 147 ASP B 73 71 ARG A Protein A 3 FT #SUB 152 148 CYS B 69 67 ILE A Protein A 2 FT #SUB 152 148 CYS B 73 71 ARG A Protein B 3 FT #SUB 152 148 CYS B 86 84 VAL A Protein S 2 FT #SUB 153 149 CYS B 73 71 ARG A Protein S 2 FT #SUB 154 150 LEU B 66 64 CYS A Protein S 1 FT #SUB 154 150 LEU B 70 68 ALA A Protein S 2 FT #SUB 155 151 ILE B 70 68 ALA A Protein S 2 FT #SUB 155 151 ILE B 74 72 GLU A Protein S 1 FT #SUB 264 260 PRO B 2 0 LYS A Protein S 2 FT #SUB 264 260 PRO B 4 2 ASP A Protein A 3 FT #SUB 265 261 LYS B 3 1 MET A Protein B 1 FT #SUB 265 261 LYS B 4 2 ASP A Protein A 7 FT #SUB 265 261 LYS B 5 3 TYR A Protein A 4 FT #SUB 265 261 LYS B 6 4 ASP A Protein S 6 FT #SUB 266 262 PRO B 5 3 TYR A Protein B 1 FT #SUB 267 263 PRO B 5 3 TYR A Protein A 4 FT #SUB 268 264 PRO B 5 3 TYR A Protein S 2 FT #HET 4 0 ALA B 9 303 EDO B B 2 FT #HET 9 5 PHE B 12 306 FMT B S 2 FT #HET 11 7 GLN B 5 505 FMT A B 2 FT #HET 13 9 SER B 5 505 FMT A A 3 FT #HET 41 37 TYR B 7 301 EDO B S 1 FT #HET 45 41 GLN B 7 301 EDO B S 4 FT #HET 45 41 GLN B 10 304 FMT B A 7 FT #HET 49 45 THR B 10 304 FMT B S 4 FT #HET 53 49 GLN B 11 305 FMT B S 1 FT #HET 63 59 GLN B 11 305 FMT B S 4 FT #HET 64 60 GLN B 8 302 EDO B S 2 FT #HET 67 63 ALA B 11 305 FMT B A 3 FT #HET 70 66 THR B 10 304 FMT B S 1 FT #HET 70 66 THR B 11 305 FMT B S 1 FT #HET 73 69 PHE B 10 304 FMT B S 2 FT #HET 74 70 LYS B 7 301 EDO B B 3 FT #HET 74 70 LYS B 10 304 FMT B S 6 FT #HET 102 98 GLU B 9 303 EDO B S 1 FT #HET 155 151 ILE B 9 303 EDO B S 4 FT #HET 156 152 VAL B 9 303 EDO B B 1 FT #HET 157 153 TYR B 8 302 EDO B A 3 FT #HET 157 153 TYR B 9 303 EDO B S 1 FT #HET 158 154 HIS B 8 302 EDO B A 9 FT #HET 160 156 TYR B 8 302 EDO B A 4 FT #HET 160 156 TYR B 11 305 FMT B S 1 FT #HET 161 157 ARG B 8 302 EDO B A 5 FT #HET 162 158 PRO B 12 306 FMT B S 1 FT #HET 188 184 TYR B 10 304 FMT B B 1 FT #HET 188 184 TYR B 11 305 FMT B S 3 FT #HET 191 187 ASP B 7 301 EDO B S 1 FT #HET 198 194 PRO B 12 306 FMT B A 6 FT #HET 199 195 PHE B 12 306 FMT B A 7 FT DISORDER 1 2 FT DISORDER 269 287 CC SEQUENCE 266 AA (ATOM); CC KAMAGNFWQS SHYLQWILDK QDLLKERQKD LKFLSEEEYW KLQIFFTNVI QALGEHLKLR CC QQVIATATVY FKRFYARYSL KSIDPVLMAP TCVFLASKVE EFGVVSNTRL IAAATSVLKT CC RFSYAFPKEF PYRMNHILEC EFYLLELMDC CLIVYHPYRP LLQYVQDMGQ EDMLLPLAWR CC IVNDTYRTDL CLLYPPFMIA LACLHVACVV QQKDARQWFA ELSVDMEKIL EIIRVILKLY CC EQWKNFDERK EMATILSKMP KPKPPP CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES DDKAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTN CC ATOM --KAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTN CC ************************************************ CC SEQRES VIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASK CC ATOM VIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASK CC ************************************************** CC SEQRES VEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELM CC ATOM VEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELM CC ************************************************** CC SEQRES DCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFM CC ATOM DCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFM CC ************************************************** CC SEQRES IALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDE CC ATOM IALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDE CC ************************************************** CC SEQRES RKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS CC ATOM RKEMATILSKMPKPKPPP------------------- CC ****************** SQ SEQUENCE 287 AA; MW; CN; DDKAMAGNFW QSSHYLQWIL DKQDLLKERQ KDLKFLSEEE YWKLQIFFTN VIQALGEHLK LRQQVIATAT VYFKRFYARY SLKSIDPVLM APTCVFLASK VEEFGVVSNT RLIAAATSVL KTRFSYAFPK EFPYRMNHIL ECEFYLLELM DCCLIVYHPY RPLLQYVQDM GQEDMLLPLA WRIVNDTYRT DLCLLYPPFM IALACLHVAC VVQQKDARQW FAELSVDMEK ILEIIRVILK LYEQWKNFDE RKEMATILSK MPKPKPPPNS EGEQGPNGSQ NSSYSQS //