ID	4EZKA	STANDARD;	PRT;	966	AA.
DT	CONVERTED FROM PDB (SEQRES) 4EZK
DE	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isof
DE	orm
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.800
CC	R-Factor	0.244
FT	#HET	660	 802 	THR	A	1	4000 	0SD	A	S	1
FT	#HET	663	 805 	ALA	A	1	4000 	0SD	A	B	1
FT	#HET	670	 812 	TRP	A	1	4000 	0SD	A	S	5
FT	#HET	689	 831 	ILE	A	1	4000 	0SD	A	S	4
FT	#HET	691	 833 	LYS	A	1	4000 	0SD	A	S	1
FT	#HET	699	 841 	ASP	A	1	4000 	0SD	A	S	1
FT	#HET	725	 867 	TYR	A	1	4000 	0SD	A	S	5
FT	#HET	737	 879 	ILE	A	1	4000 	0SD	A	S	3
FT	#HET	738	 880 	GLU	A	1	4000 	0SD	A	B	3
FT	#HET	739	 881 	ILE	A	1	4000 	0SD	A	B	2
FT	#HET	740	 882 	VAL	A	1	4000 	0SD	A	A	9
FT	#HET	748	 890 	LYS	A	1	4000 	0SD	A	S	4
FT	#HET	811	 953 	MET	A	1	4000 	0SD	A	S	5
FT	#HET	819	 961 	PHE	A	1	4000 	0SD	A	S	1
FT	#HET	821	 963 	ILE	A	1	4000 	0SD	A	S	5
FT	#HET	822	 964 	ASP	A	1	4000 	0SD	A	A	19
FT	DISORDER	112	124
FT	DISORDER	181	214
FT	DISORDER	294	317
FT	DISORDER	348	354
FT	DISORDER	381	382
FT	DISORDER	387	401
FT	DISORDER	827	838
FT	DISORDER	950	966
CC	Miss-SC	1
CC	SEQUENCE	842 AA (ATOM);
CC	MSEESQAFQR QLTALIGYDV TDVSNVHDDE LEFTRRGLVT PRMAEVASRD PKLYAMHPWV
CC	TSKPLPEYLW KKIANNCIFI VIHRSTTSQT IKVSPDDTPG AILQSFFTKM AEQDFVLRVC
CC	GRDEYLVGET PIKNFQWVRH CLKNGEEIHV VLDTPPDPAL DEVRKEECDR KFRVKIRGID
CC	IPVLPRNTDL TVFVEANIQH GQQVLCQRRT SPKPFTEEVL WNVWLEFSIK IKDLPKGALL
CC	NLQIYCLLYY VNLLLIDHRF LLRRGEYVLH MWQISGFNAD KLTSATNPDK ENSMSISILL
CC	DNHPIARAEM PNQLRKQLEA IIATDPLNPL TAEDKELLWH FRYESLKHPK AYPKLFSSVK
CC	WGQQEIVAKT YQLLARREVW DQSALDVGLT MQLLDCNFSD ENVRAIAVQK LESLEDDDVL
CC	HYLLQLVQAV KFEPYHDSAL ARFLLKRGLR NKRIGHFLFW FLRSEIAQSR HYQQRFAVIL
CC	EAYLRGCGTA MLHDFTQQVQ VIEMLQKVTL DIKSLSAEKY DVSSQVISQL KQKLENLQNS
CC	QLPESFRVPY DPGLKAGALA IEKCTVMASK KKPLWLEFKC ADPTALSNET IGIIFKHGDD
CC	LRQDMLILQI LRIMESIWET ESLDLCLLPY GCISTGDKIG MIEIVKDATT IAKIQQSTVG
CC	NTGAFKDEVL NHWLKEKSPT EEKFQAAVER FVYSCAGYCV ATFVLGIGDR HNDNIMITET
CC	GNLFHIDFGH IERVPFVLTP DFLFVMGTSG KKTSPHFQKF QDICVKAYLA LRHHTNLLII
CC	LFSMMLMTGM PQLTSKEDIE YIRDALTVGK NEEDAKKYFL DQIEVCRDKG WTVQFNWFLH
CC	LV
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRD
CC	ATOM   MSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRD
CC	       **************************************************
CC	SEQRES PKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPG
CC	ATOM   PKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPG
CC	       **************************************************
CC	SEQRES AILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQW
CC	ATOM   AILQSFFTKMA-------------EQDFVLRVCGRDEYLVGETPIKNFQW
CC	       ***********             **************************
CC	SEQRES VRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIH
CC	ATOM   VRHCLKNGEEIHVVLDTPPDPALDEVRKEE--------------------
CC	       ******************************                    
CC	SEQRES GKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQ
CC	ATOM   --------------CDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQ
CC	                     ************************************
CC	SEQRES VLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALS
CC	ATOM   VLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYC-------
CC	       *******************************************       
CC	SEQRES SKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGE
CC	ATOM   -----------------LLYYVNLLLIDHRFLLRRGEYVLHMWQISG---
CC	                        ******************************   
CC	SEQRES DQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDR
CC	ATOM   ----FNADKLTSATNPDKENSMSISILLDN--HPIA--------------
CC	           **************************  ****              
CC	SEQRES VRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKL
CC	ATOM   -RAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKL
CC	        *************************************************
CC	SEQRES FSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRA
CC	ATOM   FSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRA
CC	       **************************************************
CC	SEQRES IAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIG
CC	ATOM   IAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIG
CC	       **************************************************
CC	SEQRES HFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEML
CC	ATOM   HFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEML
CC	       **************************************************
CC	SEQRES QKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLK
CC	ATOM   QKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLK
CC	       **************************************************
CC	SEQRES AGALAIEKCTVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDM
CC	ATOM   AGALAIEKCTVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDM
CC	       **************************************************
CC	SEQRES LILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQ
CC	ATOM   LILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQ
CC	       **************************************************
CC	SEQRES QSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVL
CC	ATOM   QSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVL
CC	       **************************************************
CC	SEQRES GIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFL
CC	ATOM   GIGDRHNDNIMITETGNLFHIDFGHI------------ERVPFVLTPDFL
CC	       **************************            ************
CC	SEQRES FVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQL
CC	ATOM   FVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQL
CC	       **************************************************
CC	SEQRES TSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVL
CC	ATOM   TSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLV-
CC	       ************************************************* 
CC	SEQRES GIKQGEKHSAHHHHHH
CC	ATOM   ----------------
CC	                       
SQ	SEQUENCE	966 AA;      MW;         CN;
	MSEESQAFQR QLTALIGYDV TDVSNVHDDE LEFTRRGLVT PRMAEVASRD PKLYAMHPWV
	TSKPLPEYLW KKIANNCIFI VIHRSTTSQT IKVSPDDTPG AILQSFFTKM AKKKSLMDIP
	ESQSEQDFVL RVCGRDEYLV GETPIKNFQW VRHCLKNGEE IHVVLDTPPD PALDEVRKEE
	WPLVDDCTGV TGYHEQLTIH GKDHESVFTV SLWDCDRKFR VKIRGIDIPV LPRNTDLTVF
	VEANIQHGQQ VLCQRRTSPK PFTEEVLWNV WLEFSIKIKD LPKGALLNLQ IYCGKAPALS
	SKASAESPSS ESKGKVQLLY YVNLLLIDHR FLLRRGEYVL HMWQISGKGE DQGSFNADKL
	TSATNPDKEN SMSISILLDN YCHPIALPKH QPTPDPEGDR VRAEMPNQLR KQLEAIIATD
	PLNPLTAEDK ELLWHFRYES LKHPKAYPKL FSSVKWGQQE IVAKTYQLLA RREVWDQSAL
	DVGLTMQLLD CNFSDENVRA IAVQKLESLE DDDVLHYLLQ LVQAVKFEPY HDSALARFLL
	KRGLRNKRIG HFLFWFLRSE IAQSRHYQQR FAVILEAYLR GCGTAMLHDF TQQVQVIEML
	QKVTLDIKSL SAEKYDVSSQ VISQLKQKLE NLQNSQLPES FRVPYDPGLK AGALAIEKCT
	VMASKKKPLW LEFKCADPTA LSNETIGIIF KHGDDLRQDM LILQILRIME SIWETESLDL
	CLLPYGCIST GDKIGMIEIV KDATTIAKIQ QSTVGNTGAF KDEVLNHWLK EKSPTEEKFQ
	AAVERFVYSC AGYCVATFVL GIGDRHNDNI MITETGNLFH IDFGHILGNY KSFLGINKER
	VPFVLTPDFL FVMGTSGKKT SPHFQKFQDI CVKAYLALRH HTNLLIILFS MMLMTGMPQL
	TSKEDIEYIR DALTVGKNEE DAKKYFLDQI EVCRDKGWTV QFNWFLHLVL GIKQGEKHSA
	HHHHHH
//