ID 4EO6A STANDARD; PRT; 577 AA. DT CONVERTED FROM PDB (SEQRES) 4EO6 DE RNA-directed RNA polymerase OS Hepatitis C virus (isolate BK) CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.790 CC R-Factor 0.181 FT #SUB 8 1 HIS A 69 62 ASP B Protein S 2 FT #SUB 8 1 HIS A 73 66 ASP B Protein S 6 FT #SUB 64 57 LEU A 69 62 ASP B Protein A 4 FT #SUB 65 58 GLN A 67 60 LEU B Protein B 1 FT #SUB 65 58 GLN A 68 61 ASP B Protein B 2 FT #SUB 65 58 GLN A 69 62 ASP B Protein B 5 FT #SUB 65 58 GLN A 72 65 ARG B Protein A 5 FT #SUB 66 59 VAL A 66 59 VAL B Protein S 1 FT #SUB 66 59 VAL A 67 60 LEU B Protein B 2 FT #SUB 67 60 LEU A 65 58 GLN B Protein B 1 FT #SUB 67 60 LEU A 66 59 VAL B Protein B 2 FT #SUB 67 60 LEU A 67 60 LEU B Protein A 9 FT #SUB 67 60 LEU A 72 65 ARG B Protein S 2 FT #SUB 68 61 ASP A 65 58 GLN B Protein B 2 FT #SUB 69 62 ASP A 8 1 HIS B Protein S 2 FT #SUB 69 62 ASP A 64 57 LEU B Protein S 3 FT #SUB 69 62 ASP A 65 58 GLN B Protein A 5 FT #SUB 72 65 ARG A 65 58 GLN B Protein S 6 FT #SUB 72 65 ARG A 67 60 LEU B Protein S 2 FT #SUB 72 65 ARG A 238 231 ASN B Protein S 1 FT #SUB 73 66 ASP A 8 1 HIS B Protein S 6 FT #SUB 76 69 LYS A 237 230 GLU B Protein S 5 FT #SUB 237 230 GLU A 76 69 LYS B Protein S 5 FT #SUB 238 231 ASN A 72 65 ARG B Protein S 1 FT #HET 426 419 LEU A 1 600 0S2 A S 4 FT #HET 429 422 ARG A 1 600 0S2 A S 2 FT #HET 430 423 MET A 1 600 0S2 A B 1 FT #HET 481 474 LEU A 1 600 0S2 A B 2 FT #HET 482 475 HIS A 1 600 0S2 A A 3 FT #HET 483 476 SER A 1 600 0S2 A B 7 FT #HET 484 477 TYR A 1 600 0S2 A A 7 FT #HET 489 482 ILE A 1 600 0S2 A A 4 FT #HET 492 485 VAL A 1 600 0S2 A S 1 FT #HET 493 486 ALA A 1 600 0S2 A A 2 FT #HET 504 497 LEU A 1 600 0S2 A S 1 FT #HET 535 528 TRP A 1 600 0S2 A S 8 FT DISORDER 1 7 FT DISORDER 156 160 FT DISORDER 570 577 CC SEQUENCE 557 AA (ATOM); CC HHSYTWTGAL ITPCAAEESK LPINALSNSL LRHHNMVYAT TSRSAGLRQK KVTFDRLQVL CC DDHYRDVLKE MKAKASTVKA KLLSVEEACK LTPPHSAKSK FGYGAKDVRN LSSKAVNHIH CC SVWKDLLEDT VTPIDTTIMA KNEVFCVQRK PARLIVFPDL GVRVCEKMAL YDVVSTLPQV CC VMGSSYGFQY SPGQRVEFLV NTWKSKKNPM GFSYDTRCFD STVTENDIRV EESIYQCCDL CC APEARQAIKS LTERLYIGGP LTNSKGQNCG YRRCRASGVL TTSCGNTLTC YLKASAACRA CC AKLQDCTMLV NGDDLVVICE SAGVQEDAAS LRAFTEAMTR YSAPPGDPPQ PEYDLELITS CC CSSNVSVAHD ASGKRVYYLT RDPTTPLARA AWETARHTPV NSWLGNIIMY APTLWARMIL CC MTHFFSILLA QEQLEKALDC QIYGACYSIE PLDLPQIIER LHGLSAFSLH SYSPGEINRV CC ASCLRKLGVP PLRVWRHRAR SVRARLLSQG GRAATCGKYL FNWAVKTKLK LTPIPAASQL CC DLSGWFVAGY SGGDIYH CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MASHHHHHHSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSR CC ATOM -------HHSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSR CC ******************************************* CC SEQRES SAGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTP CC ATOM SAGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTP CC ************************************************** CC SEQRES PHSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNE CC ATOM PHSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNE CC ************************************************** CC SEQRES VFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGF CC ATOM VFCVQ-----RKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGF CC ***** **************************************** CC SEQRES QYSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCC CC ATOM QYSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCC CC ************************************************** CC SEQRES DLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTL CC ATOM DLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTL CC ************************************************** CC SEQRES TCYLKASAACRAAKLQDCTMLVNGDDLVVICESAGVQEDAASLRAFTEAM CC ATOM TCYLKASAACRAAKLQDCTMLVNGDDLVVICESAGVQEDAASLRAFTEAM CC ************************************************** CC SEQRES TRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLA CC ATOM TRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLA CC ************************************************** CC SEQRES RAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKAL CC ATOM RAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKAL CC ************************************************** CC SEQRES DCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLG CC ATOM DCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLG CC ************************************************** CC SEQRES VPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAAS CC ATOM VPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAAS CC ************************************************** CC SEQRES QLDLSGWFVAGYSGGDIYHSLSRARPR CC ATOM QLDLSGWFVAGYSGGDIYH-------- CC ******************* SQ SEQUENCE 577 AA; MW; CN; MASHHHHHHS YTWTGALITP CAAEESKLPI NALSNSLLRH HNMVYATTSR SAGLRQKKVT FDRLQVLDDH YRDVLKEMKA KASTVKAKLL SVEEACKLTP PHSAKSKFGY GAKDVRNLSS KAVNHIHSVW KDLLEDTVTP IDTTIMAKNE VFCVQPEKGG RKPARLIVFP DLGVRVCEKM ALYDVVSTLP QVVMGSSYGF QYSPGQRVEF LVNTWKSKKN PMGFSYDTRC FDSTVTENDI RVEESIYQCC DLAPEARQAI KSLTERLYIG GPLTNSKGQN CGYRRCRASG VLTTSCGNTL TCYLKASAAC RAAKLQDCTM LVNGDDLVVI CESAGVQEDA ASLRAFTEAM TRYSAPPGDP PQPEYDLELI TSCSSNVSVA HDASGKRVYY LTRDPTTPLA RAAWETARHT PVNSWLGNII MYAPTLWARM ILMTHFFSIL LAQEQLEKAL DCQIYGACYS IEPLDLPQII ERLHGLSAFS LHSYSPGEIN RVASCLRKLG VPPLRVWRHR ARSVRARLLS QGGRAATCGK YLFNWAVKTK LKLTPIPAAS QLDLSGWFVA GYSGGDIYHS LSRARPR // ID 4EO6B STANDARD; PRT; 577 AA. DT CONVERTED FROM PDB (SEQRES) 4EO6 DE RNA-directed RNA polymerase OS Hepatitis C virus (isolate BK) CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.790 CC R-Factor 0.181 FT #SUB 8 1 HIS B 69 62 ASP A Protein S 2 FT #SUB 8 1 HIS B 73 66 ASP A Protein S 6 FT #SUB 64 57 LEU B 69 62 ASP A Protein A 3 FT #SUB 65 58 GLN B 67 60 LEU A Protein B 1 FT #SUB 65 58 GLN B 68 61 ASP A Protein B 2 FT #SUB 65 58 GLN B 69 62 ASP A Protein B 5 FT #SUB 65 58 GLN B 72 65 ARG A Protein A 6 FT #SUB 66 59 VAL B 66 59 VAL A Protein S 1 FT #SUB 66 59 VAL B 67 60 LEU A Protein B 2 FT #SUB 67 60 LEU B 65 58 GLN A Protein B 1 FT #SUB 67 60 LEU B 66 59 VAL A Protein B 2 FT #SUB 67 60 LEU B 67 60 LEU A Protein A 9 FT #SUB 67 60 LEU B 72 65 ARG A Protein S 2 FT #SUB 68 61 ASP B 65 58 GLN A Protein B 2 FT #SUB 69 62 ASP B 8 1 HIS A Protein S 2 FT #SUB 69 62 ASP B 64 57 LEU A Protein S 4 FT #SUB 69 62 ASP B 65 58 GLN A Protein A 5 FT #SUB 72 65 ARG B 65 58 GLN A Protein S 5 FT #SUB 72 65 ARG B 67 60 LEU A Protein S 2 FT #SUB 72 65 ARG B 238 231 ASN A Protein S 1 FT #SUB 73 66 ASP B 8 1 HIS A Protein S 6 FT #SUB 76 69 LYS B 237 230 GLU A Protein S 5 FT #SUB 237 230 GLU B 76 69 LYS A Protein S 5 FT #SUB 238 231 ASN B 72 65 ARG A Protein S 1 FT #HET 426 419 LEU B 2 600 0S2 B S 5 FT #HET 429 422 ARG B 2 600 0S2 B S 2 FT #HET 430 423 MET B 2 600 0S2 B B 1 FT #HET 481 474 LEU B 2 600 0S2 B B 2 FT #HET 482 475 HIS B 2 600 0S2 B A 3 FT #HET 483 476 SER B 2 600 0S2 B B 7 FT #HET 484 477 TYR B 2 600 0S2 B A 7 FT #HET 489 482 ILE B 2 600 0S2 B A 4 FT #HET 492 485 VAL B 2 600 0S2 B S 2 FT #HET 493 486 ALA B 2 600 0S2 B A 2 FT #HET 504 497 LEU B 2 600 0S2 B S 1 FT #HET 535 528 TRP B 2 600 0S2 B S 9 FT DISORDER 1 7 FT DISORDER 156 160 FT DISORDER 573 577 CC SEQUENCE 560 AA (ATOM); CC HHSYTWTGAL ITPCAAEESK LPINALSNSL LRHHNMVYAT TSRSAGLRQK KVTFDRLQVL CC DDHYRDVLKE MKAKASTVKA KLLSVEEACK LTPPHSAKSK FGYGAKDVRN LSSKAVNHIH CC SVWKDLLEDT VTPIDTTIMA KNEVFCVQRK PARLIVFPDL GVRVCEKMAL YDVVSTLPQV CC VMGSSYGFQY SPGQRVEFLV NTWKSKKNPM GFSYDTRCFD STVTENDIRV EESIYQCCDL CC APEARQAIKS LTERLYIGGP LTNSKGQNCG YRRCRASGVL TTSCGNTLTC YLKASAACRA CC AKLQDCTMLV NGDDLVVICE SAGVQEDAAS LRAFTEAMTR YSAPPGDPPQ PEYDLELITS CC CSSNVSVAHD ASGKRVYYLT RDPTTPLARA AWETARHTPV NSWLGNIIMY APTLWARMIL CC MTHFFSILLA QEQLEKALDC QIYGACYSIE PLDLPQIIER LHGLSAFSLH SYSPGEINRV CC ASCLRKLGVP PLRVWRHRAR SVRARLLSQG GRAATCGKYL FNWAVKTKLK LTPIPAASQL CC DLSGWFVAGY SGGDIYHSLS CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MASHHHHHHSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSR CC ATOM -------HHSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSR CC ******************************************* CC SEQRES SAGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTP CC ATOM SAGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTP CC ************************************************** CC SEQRES PHSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNE CC ATOM PHSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNE CC ************************************************** CC SEQRES VFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGF CC ATOM VFCVQ-----RKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGF CC ***** **************************************** CC SEQRES QYSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCC CC ATOM QYSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCC CC ************************************************** CC SEQRES DLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTL CC ATOM DLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTL CC ************************************************** CC SEQRES TCYLKASAACRAAKLQDCTMLVNGDDLVVICESAGVQEDAASLRAFTEAM CC ATOM TCYLKASAACRAAKLQDCTMLVNGDDLVVICESAGVQEDAASLRAFTEAM CC ************************************************** CC SEQRES TRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLA CC ATOM TRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLA CC ************************************************** CC SEQRES RAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKAL CC ATOM RAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKAL CC ************************************************** CC SEQRES DCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLG CC ATOM DCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLG CC ************************************************** CC SEQRES VPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAAS CC ATOM VPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAAS CC ************************************************** CC SEQRES QLDLSGWFVAGYSGGDIYHSLSRARPR CC ATOM QLDLSGWFVAGYSGGDIYHSLS----- CC ********************** SQ SEQUENCE 577 AA; MW; CN; MASHHHHHHS YTWTGALITP CAAEESKLPI NALSNSLLRH HNMVYATTSR SAGLRQKKVT FDRLQVLDDH YRDVLKEMKA KASTVKAKLL SVEEACKLTP PHSAKSKFGY GAKDVRNLSS KAVNHIHSVW KDLLEDTVTP IDTTIMAKNE VFCVQPEKGG RKPARLIVFP DLGVRVCEKM ALYDVVSTLP QVVMGSSYGF QYSPGQRVEF LVNTWKSKKN PMGFSYDTRC FDSTVTENDI RVEESIYQCC DLAPEARQAI KSLTERLYIG GPLTNSKGQN CGYRRCRASG VLTTSCGNTL TCYLKASAAC RAAKLQDCTM LVNGDDLVVI CESAGVQEDA ASLRAFTEAM TRYSAPPGDP PQPEYDLELI TSCSSNVSVA HDASGKRVYY LTRDPTTPLA RAAWETARHT PVNSWLGNII MYAPTLWARM ILMTHFFSIL LAQEQLEKAL DCQIYGACYS IEPLDLPQII ERLHGLSAFS LHSYSPGEIN RVASCLRKLG VPPLRVWRHR ARSVRARLLS QGGRAATCGK YLFNWAVKTK LKLTPIPAAS QLDLSGWFVA GYSGGDIYHS LSRARPR //