ID	4EHZA	STANDARD;	PRT;	302	AA.
DT	CONVERTED FROM PDB (SEQRES) 4EHZ
DE	Tyrosine-protein kinase JAK1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.170
CC	R-Factor	0.174
FT	#SUB	185	1037 	VAL	A	251	1103 	ARG	B	Protein	B	1
FT	#SUB	186	1038 	LYS	A	244	1096 	HIS	B	Protein	B	2
FT	#SUB	186	1038 	LYS	A	251	1103 	ARG	B	Protein	B	1
FT	#SUB	188	1040 	ASP	A	244	1096 	HIS	B	Protein	S	8
FT	#SUB	188	1040 	ASP	A	247	1099 	MET	B	Protein	A	7
FT	#SUB	188	1040 	ASP	A	251	1103 	ARG	B	Protein	S	5
FT	#SUB	189	1041 	ARG	A	243	1095 	THR	B	Protein	S	6
FT	#SUB	189	1041 	ARG	A	244	1096 	HIS	B	Protein	A	2
FT	#SUB	189	1041 	ARG	A	245	1097 	GLY	B	Protein	S	3
FT	#SUB	189	1041 	ARG	A	246	1098 	GLN	B	Protein	B	2
FT	#SUB	191	1043 	SER	A	246	1098 	GLN	B	Protein	B	1
FT	#SUB	193	1045 	VAL	A	246	1098 	GLN	B	Protein	S	2
FT	#SUB	201	1053 	LEU	A	247	1099 	MET	B	Protein	B	1
FT	#SUB	201	1053 	LEU	A	250	1102 	THR	B	Protein	B	1
FT	#SUB	202	1054 	MET	A	250	1102 	THR	B	Protein	B	2
FT	#SUB	202	1054 	MET	A	254	1106 	ASN	B	Protein	B	4
FT	#SUB	204	1056 	SER	A	251	1103 	ARG	B	Protein	S	2
FT	#SUB	243	1095 	THR	A	189	1041 	ARG	B	Protein	A	5
FT	#SUB	244	1096 	HIS	A	186	1038 	LYS	B	Protein	S	2
FT	#SUB	244	1096 	HIS	A	188	1040 	ASP	B	Protein	A	7
FT	#SUB	244	1096 	HIS	A	189	1041 	ARG	B	Protein	B	1
FT	#SUB	245	1097 	GLY	A	189	1041 	ARG	B	Protein	B	2
FT	#SUB	246	1098 	GLN	A	189	1041 	ARG	B	Protein	S	1
FT	#SUB	246	1098 	GLN	A	191	1043 	SER	B	Protein	S	2
FT	#SUB	246	1098 	GLN	A	193	1045 	VAL	B	Protein	S	2
FT	#SUB	246	1098 	GLN	A	249	1101 	VAL	B	Protein	B	1
FT	#SUB	247	1099 	MET	A	188	1040 	ASP	B	Protein	S	8
FT	#SUB	247	1099 	MET	A	193	1045 	VAL	B	Protein	S	1
FT	#SUB	247	1099 	MET	A	201	1053 	LEU	B	Protein	S	1
FT	#SUB	249	1101 	VAL	A	246	1098 	GLN	B	Protein	S	2
FT	#SUB	249	1101 	VAL	A	247	1099 	MET	B	Protein	S	1
FT	#SUB	249	1101 	VAL	A	250	1102 	THR	B	Protein	S	1
FT	#SUB	250	1102 	THR	A	201	1053 	LEU	B	Protein	S	1
FT	#SUB	250	1102 	THR	A	202	1054 	MET	B	Protein	S	1
FT	#SUB	250	1102 	THR	A	249	1101 	VAL	B	Protein	S	1
FT	#SUB	251	1103 	ARG	A	185	1037 	VAL	B	Protein	S	1
FT	#SUB	251	1103 	ARG	A	186	1038 	LYS	B	Protein	S	2
FT	#SUB	251	1103 	ARG	A	188	1040 	ASP	B	Protein	S	5
FT	#SUB	251	1103 	ARG	A	204	1056 	SER	B	Protein	S	3
FT	#SUB	254	1106 	ASN	A	202	1054 	MET	B	Protein	S	4
FT	#SUB	26	 878 	ILE	A	291	1143 	GLN	C	Protein	S	1
FT	#HET	14	 866 	ASP	A	4	1204 	EDO	A	B	1
FT	#HET	15	 867 	PRO	A	4	1204 	EDO	A	B	5
FT	#HET	17	 869 	HIS	A	4	1204 	EDO	A	B	2
FT	#HET	18	 870 	PHE	A	4	1204 	EDO	A	S	3
FT	#HET	23	 875 	LEU	A	5	1205 	EDO	A	B	2
FT	#HET	27	 879 	ARG	A	2	1202 	EDO	A	S	3
FT	#HET	29	 881 	LEU	A	1	1201 	JAK	A	B	1
FT	#HET	29	 881 	LEU	A	2	1202 	EDO	A	S	1
FT	#HET	37	 889 	VAL	A	1	1201 	JAK	A	S	4
FT	#HET	38	 890 	GLU	A	5	1205 	EDO	A	S	2
FT	#HET	40	 892 	CYS	A	5	1205 	EDO	A	S	1
FT	#HET	54	 906 	ALA	A	1	1201 	JAK	A	S	3
FT	#HET	101	 953 	LYS	A	5	1205 	EDO	A	S	4
FT	#HET	104	 956 	MET	A	1	1201 	JAK	A	S	2
FT	#HET	105	 957 	GLU	A	1	1201 	JAK	A	B	3
FT	#HET	106	 958 	PHE	A	1	1201 	JAK	A	A	5
FT	#HET	106	 958 	PHE	A	2	1202 	EDO	A	S	1
FT	#HET	107	 959 	LEU	A	1	1201 	JAK	A	B	6
FT	#HET	108	 960 	PRO	A	2	1202 	EDO	A	B	3
FT	#HET	109	 961 	SER	A	2	1202 	EDO	A	B	1
FT	#HET	110	 962 	GLY	A	1	1201 	JAK	A	B	1
FT	#HET	110	 962 	GLY	A	2	1202 	EDO	A	B	5
FT	#HET	114	 966 	GLU	A	1	1201 	JAK	A	S	2
FT	#HET	124	 976 	ASN	A	6	1206 	EDO	A	S	5
FT	#HET	125	 977 	LEU	A	3	1203 	EDO	A	A	3
FT	#HET	126	 978 	LYS	A	6	1206 	EDO	A	A	2
FT	#HET	127	 979 	GLN	A	6	1206 	EDO	A	A	6
FT	#HET	128	 980 	GLN	A	3	1203 	EDO	A	S	5
FT	#HET	130	 982 	LYS	A	6	1206 	EDO	A	S	4
FT	#HET	155	1007 	ARG	A	1	1201 	JAK	A	B	2
FT	#HET	156	1008 	ASN	A	1	1201 	JAK	A	S	2
FT	#HET	158	1010 	LEU	A	1	1201 	JAK	A	S	11
FT	#HET	168	1020 	GLY	A	1	1201 	JAK	A	B	1
FT	#HET	169	1021 	ASP	A	1	1201 	JAK	A	S	1
FT	#HET	223	1075 	LEU	A	3	1203 	EDO	A	B	3
FT	#HET	225	1077 	TYR	A	3	1203 	EDO	A	S	5
FT	#HET	266	1118 	PRO	A	3	1203 	EDO	A	B	2
FT	#HET	267	1119 	ASN	A	3	1203 	EDO	A	A	3
FT	#HET	268	1120 	CYS	A	3	1203 	EDO	A	B	1
FT	DISORDER	1	5
FT	DISORDER	61	65
CC	SEQUENCE	292 AA (ATOM);
CC	EKKPATEVDP THFEKRFLKR IRDLGEGHFG KVELCRYDPE GDNTGEQVAV KSLKPHIADL
CC	KKEIEILRNL YHENIVKYKG ICTEDGGNGI KLIMEFLPSG SLKEYLPKNK NKINLKQQLK
CC	YAVQICKGMD YLGSRQYVHR DLAARNVLVE SEHQVKIGDF GLTKAIETDK EYYTVKDDRD
CC	SPVFWYAPEC LMQSKFYIAS DVWSFGVTLH ELLTYCDSDS SPMALFLKMI GPTHGQMTVT
CC	RLVNTLKEGK RLPCPPNCPD EVYQLMRKCW EFQPSNRTSF QNLIEGFEAL LK
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES GDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	ATOM   -----EKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	            *********************************************
CC	SEQRES EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGI
CC	ATOM   EQVAVKSLKP-----HIADLKKEIEILRNLYHENIVKYKGICTEDGGNGI
CC	       **********     ***********************************
CC	SEQRES KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	ATOM   KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	       **************************************************
CC	SEQRES DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	ATOM   DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	       **************************************************
CC	SEQRES LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	ATOM   LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	       **************************************************
CC	SEQRES RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	ATOM   RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	       **************************************************
CC	SEQRES LK
CC	ATOM   LK
CC	       **
SQ	SEQUENCE	302 AA;      MW;         CN;
	GDIVSEKKPA TEVDPTHFEK RFLKRIRDLG EGHFGKVELC RYDPEGDNTG EQVAVKSLKP
	ESGGNHIADL KKEIEILRNL YHENIVKYKG ICTEDGGNGI KLIMEFLPSG SLKEYLPKNK
	NKINLKQQLK YAVQICKGMD YLGSRQYVHR DLAARNVLVE SEHQVKIGDF GLTKAIETDK
	EYYTVKDDRD SPVFWYAPEC LMQSKFYIAS DVWSFGVTLH ELLTYCDSDS SPMALFLKMI
	GPTHGQMTVT RLVNTLKEGK RLPCPPNCPD EVYQLMRKCW EFQPSNRTSF QNLIEGFEAL
	LK
//
ID	4EHZB	STANDARD;	PRT;	302	AA.
DT	CONVERTED FROM PDB (SEQRES) 4EHZ
DE	Tyrosine-protein kinase JAK1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.170
CC	R-Factor	0.174
FT	#SUB	185	1037 	VAL	B	251	1103 	ARG	A	Protein	B	1
FT	#SUB	186	1038 	LYS	B	244	1096 	HIS	A	Protein	B	2
FT	#SUB	186	1038 	LYS	B	251	1103 	ARG	A	Protein	B	2
FT	#SUB	188	1040 	ASP	B	244	1096 	HIS	A	Protein	S	7
FT	#SUB	188	1040 	ASP	B	247	1099 	MET	A	Protein	A	8
FT	#SUB	188	1040 	ASP	B	251	1103 	ARG	A	Protein	S	5
FT	#SUB	189	1041 	ARG	B	243	1095 	THR	A	Protein	S	5
FT	#SUB	189	1041 	ARG	B	244	1096 	HIS	A	Protein	B	1
FT	#SUB	189	1041 	ARG	B	245	1097 	GLY	A	Protein	S	2
FT	#SUB	189	1041 	ARG	B	246	1098 	GLN	A	Protein	B	1
FT	#SUB	191	1043 	SER	B	246	1098 	GLN	A	Protein	B	2
FT	#SUB	193	1045 	VAL	B	246	1098 	GLN	A	Protein	S	2
FT	#SUB	193	1045 	VAL	B	247	1099 	MET	A	Protein	S	1
FT	#SUB	201	1053 	LEU	B	247	1099 	MET	A	Protein	B	1
FT	#SUB	201	1053 	LEU	B	250	1102 	THR	A	Protein	B	1
FT	#SUB	202	1054 	MET	B	250	1102 	THR	A	Protein	B	1
FT	#SUB	202	1054 	MET	B	254	1106 	ASN	A	Protein	B	4
FT	#SUB	204	1056 	SER	B	251	1103 	ARG	A	Protein	S	3
FT	#SUB	243	1095 	THR	B	189	1041 	ARG	A	Protein	B	6
FT	#SUB	244	1096 	HIS	B	186	1038 	LYS	A	Protein	S	2
FT	#SUB	244	1096 	HIS	B	188	1040 	ASP	A	Protein	A	8
FT	#SUB	244	1096 	HIS	B	189	1041 	ARG	A	Protein	B	2
FT	#SUB	245	1097 	GLY	B	189	1041 	ARG	A	Protein	B	3
FT	#SUB	246	1098 	GLN	B	189	1041 	ARG	A	Protein	S	2
FT	#SUB	246	1098 	GLN	B	191	1043 	SER	A	Protein	S	1
FT	#SUB	246	1098 	GLN	B	193	1045 	VAL	A	Protein	S	2
FT	#SUB	246	1098 	GLN	B	249	1101 	VAL	A	Protein	B	2
FT	#SUB	247	1099 	MET	B	188	1040 	ASP	A	Protein	S	7
FT	#SUB	247	1099 	MET	B	201	1053 	LEU	A	Protein	S	1
FT	#SUB	247	1099 	MET	B	249	1101 	VAL	A	Protein	S	1
FT	#SUB	249	1101 	VAL	B	246	1098 	GLN	A	Protein	S	1
FT	#SUB	249	1101 	VAL	B	250	1102 	THR	A	Protein	S	1
FT	#SUB	250	1102 	THR	B	201	1053 	LEU	A	Protein	S	1
FT	#SUB	250	1102 	THR	B	202	1054 	MET	A	Protein	S	2
FT	#SUB	250	1102 	THR	B	249	1101 	VAL	A	Protein	S	1
FT	#SUB	251	1103 	ARG	B	185	1037 	VAL	A	Protein	S	1
FT	#SUB	251	1103 	ARG	B	186	1038 	LYS	A	Protein	S	1
FT	#SUB	251	1103 	ARG	B	188	1040 	ASP	A	Protein	S	5
FT	#SUB	251	1103 	ARG	B	204	1056 	SER	A	Protein	S	2
FT	#SUB	254	1106 	ASN	B	202	1054 	MET	A	Protein	S	4
FT	#SUB	20	 872 	LYS	B	179	1031 	ASP	D	Protein	S	5
FT	#SUB	24	 876 	LYS	B	144	 996 	SER	D	Protein	S	2
FT	#SUB	25	 877 	ARG	B	285	1137 	SER	D	Protein	S	4
FT	#SUB	25	 877 	ARG	B	287	1139 	ARG	D	Protein	S	2
FT	#SUB	25	 877 	ARG	B	289	1141 	SER	D	Protein	B	2
FT	#SUB	26	 878 	ILE	B	289	1141 	SER	D	Protein	A	7
FT	#SUB	26	 878 	ILE	B	292	1144 	ASN	D	Protein	B	1
FT	#SUB	27	 879 	ARG	B	292	1144 	ASN	D	Protein	S	1
FT	#SUB	28	 880 	ASP	B	285	1137 	SER	D	Protein	S	1
FT	#SUB	41	 893 	ARG	B	291	1143 	GLN	D	Protein	S	3
FT	#SUB	48	 900 	ASN	B	140	 992 	ASP	D	Protein	S	3
FT	#SUB	48	 900 	ASN	B	291	1143 	GLN	D	Protein	S	6
FT	#HET	23	 875 	LEU	B	8	1202 	EDO	B	B	1
FT	#HET	29	 881 	LEU	B	7	1201 	JAK	B	B	4
FT	#HET	30	 882 	GLY	B	7	1201 	JAK	B	B	1
FT	#HET	37	 889 	VAL	B	7	1201 	JAK	B	S	3
FT	#HET	38	 890 	GLU	B	8	1202 	EDO	B	S	3
FT	#HET	54	 906 	ALA	B	7	1201 	JAK	B	S	3
FT	#HET	55	 907 	VAL	B	8	1202 	EDO	B	S	1
FT	#HET	101	 953 	LYS	B	8	1202 	EDO	B	S	5
FT	#HET	104	 956 	MET	B	7	1201 	JAK	B	S	2
FT	#HET	105	 957 	GLU	B	7	1201 	JAK	B	B	3
FT	#HET	106	 958 	PHE	B	7	1201 	JAK	B	A	5
FT	#HET	107	 959 	LEU	B	7	1201 	JAK	B	B	7
FT	#HET	110	 962 	GLY	B	7	1201 	JAK	B	B	1
FT	#HET	114	 966 	GLU	B	7	1201 	JAK	B	S	2
FT	#HET	155	1007 	ARG	B	7	1201 	JAK	B	B	2
FT	#HET	156	1008 	ASN	B	7	1201 	JAK	B	S	2
FT	#HET	158	1010 	LEU	B	7	1201 	JAK	B	S	12
FT	#HET	168	1020 	GLY	B	7	1201 	JAK	B	B	2
FT	#HET	169	1021 	ASP	B	7	1201 	JAK	B	S	2
FT	DISORDER	1	12
FT	DISORDER	61	64
FT	DISORDER	94	97
CC	SEQUENCE	282 AA (ATOM);
CC	VDPTHFEKRF LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ VAVKSLKPNH IADLKKEIEI
CC	LRNLYHENIV KYKGICTNGI KLIMEFLPSG SLKEYLPKNK NKINLKQQLK YAVQICKGMD
CC	YLGSRQYVHR DLAARNVLVE SEHQVKIGDF GLTKAIETDK EYYTVKDDRD SPVFWYAPEC
CC	LMQSKFYIAS DVWSFGVTLH ELLTYCDSDS SPMALFLKMI GPTHGQMTVT RLVNTLKEGK
CC	RLPCPPNCPD EVYQLMRKCW EFQPSNRTSF QNLIEGFEAL LK
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES GDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	ATOM   ------------VDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	                   **************************************
CC	SEQRES EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGI
CC	ATOM   EQVAVKSLKP----NHIADLKKEIEILRNLYHENIVKYKGICT----NGI
CC	       **********    *****************************    ***
CC	SEQRES KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	ATOM   KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	       **************************************************
CC	SEQRES DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	ATOM   DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	       **************************************************
CC	SEQRES LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	ATOM   LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	       **************************************************
CC	SEQRES RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	ATOM   RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	       **************************************************
CC	SEQRES LK
CC	ATOM   LK
CC	       **
SQ	SEQUENCE	302 AA;      MW;         CN;
	GDIVSEKKPA TEVDPTHFEK RFLKRIRDLG EGHFGKVELC RYDPEGDNTG EQVAVKSLKP
	ESGGNHIADL KKEIEILRNL YHENIVKYKG ICTEDGGNGI KLIMEFLPSG SLKEYLPKNK
	NKINLKQQLK YAVQICKGMD YLGSRQYVHR DLAARNVLVE SEHQVKIGDF GLTKAIETDK
	EYYTVKDDRD SPVFWYAPEC LMQSKFYIAS DVWSFGVTLH ELLTYCDSDS SPMALFLKMI
	GPTHGQMTVT RLVNTLKEGK RLPCPPNCPD EVYQLMRKCW EFQPSNRTSF QNLIEGFEAL
	LK
//
ID	4EHZC	STANDARD;	PRT;	302	AA.
DT	CONVERTED FROM PDB (SEQRES) 4EHZ
DE	Tyrosine-protein kinase JAK1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.170
CC	R-Factor	0.174
FT	#SUB	291	1143 	GLN	C	26	 878 	ILE	A	Protein	S	1
FT	#SUB	185	1037 	VAL	C	251	1103 	ARG	D	Protein	B	2
FT	#SUB	186	1038 	LYS	C	244	1096 	HIS	D	Protein	B	2
FT	#SUB	186	1038 	LYS	C	251	1103 	ARG	D	Protein	B	1
FT	#SUB	188	1040 	ASP	C	244	1096 	HIS	D	Protein	S	7
FT	#SUB	188	1040 	ASP	C	247	1099 	MET	D	Protein	A	7
FT	#SUB	188	1040 	ASP	C	251	1103 	ARG	D	Protein	S	4
FT	#SUB	189	1041 	ARG	C	243	1095 	THR	D	Protein	S	8
FT	#SUB	189	1041 	ARG	C	244	1096 	HIS	D	Protein	A	2
FT	#SUB	189	1041 	ARG	C	246	1098 	GLN	D	Protein	B	1
FT	#SUB	191	1043 	SER	C	246	1098 	GLN	D	Protein	B	2
FT	#SUB	193	1045 	VAL	C	246	1098 	GLN	D	Protein	S	1
FT	#SUB	193	1045 	VAL	C	247	1099 	MET	D	Protein	S	1
FT	#SUB	201	1053 	LEU	C	247	1099 	MET	D	Protein	B	1
FT	#SUB	201	1053 	LEU	C	250	1102 	THR	D	Protein	B	3
FT	#SUB	202	1054 	MET	C	250	1102 	THR	D	Protein	B	3
FT	#SUB	202	1054 	MET	C	254	1106 	ASN	D	Protein	B	4
FT	#SUB	204	1056 	SER	C	251	1103 	ARG	D	Protein	S	1
FT	#SUB	243	1095 	THR	C	189	1041 	ARG	D	Protein	B	3
FT	#SUB	244	1096 	HIS	C	186	1038 	LYS	D	Protein	S	2
FT	#SUB	244	1096 	HIS	C	188	1040 	ASP	D	Protein	A	5
FT	#SUB	244	1096 	HIS	C	189	1041 	ARG	D	Protein	B	2
FT	#SUB	245	1097 	GLY	C	189	1041 	ARG	D	Protein	B	3
FT	#SUB	246	1098 	GLN	C	191	1043 	SER	D	Protein	S	1
FT	#SUB	246	1098 	GLN	C	193	1045 	VAL	D	Protein	S	2
FT	#SUB	246	1098 	GLN	C	249	1101 	VAL	D	Protein	B	2
FT	#SUB	247	1099 	MET	C	188	1040 	ASP	D	Protein	S	8
FT	#SUB	247	1099 	MET	C	193	1045 	VAL	D	Protein	S	1
FT	#SUB	247	1099 	MET	C	201	1053 	LEU	D	Protein	S	1
FT	#SUB	249	1101 	VAL	C	246	1098 	GLN	D	Protein	S	1
FT	#SUB	249	1101 	VAL	C	250	1102 	THR	D	Protein	S	1
FT	#SUB	250	1102 	THR	C	201	1053 	LEU	D	Protein	S	3
FT	#SUB	250	1102 	THR	C	202	1054 	MET	D	Protein	S	3
FT	#SUB	250	1102 	THR	C	249	1101 	VAL	D	Protein	S	1
FT	#SUB	251	1103 	ARG	C	185	1037 	VAL	D	Protein	S	1
FT	#SUB	251	1103 	ARG	C	186	1038 	LYS	D	Protein	S	2
FT	#SUB	251	1103 	ARG	C	188	1040 	ASP	D	Protein	S	5
FT	#SUB	251	1103 	ARG	C	204	1056 	SER	D	Protein	S	3
FT	#SUB	254	1106 	ASN	C	202	1054 	MET	D	Protein	S	3
FT	#SUB	254	1106 	ASN	C	203	1055 	GLN	D	Protein	S	1
FT	#HET	27	 879 	ARG	C	10	1202 	EDO	C	S	5
FT	#HET	29	 881 	LEU	C	9	1201 	JAK	C	B	3
FT	#HET	29	 881 	LEU	C	10	1202 	EDO	C	S	2
FT	#HET	37	 889 	VAL	C	9	1201 	JAK	C	S	4
FT	#HET	54	 906 	ALA	C	9	1201 	JAK	C	S	3
FT	#HET	104	 956 	MET	C	9	1201 	JAK	C	S	2
FT	#HET	105	 957 	GLU	C	9	1201 	JAK	C	B	2
FT	#HET	106	 958 	PHE	C	9	1201 	JAK	C	A	4
FT	#HET	107	 959 	LEU	C	9	1201 	JAK	C	B	4
FT	#HET	108	 960 	PRO	C	10	1202 	EDO	C	B	3
FT	#HET	109	 961 	SER	C	10	1202 	EDO	C	B	2
FT	#HET	110	 962 	GLY	C	9	1201 	JAK	C	B	1
FT	#HET	110	 962 	GLY	C	10	1202 	EDO	C	B	4
FT	#HET	114	 966 	GLU	C	9	1201 	JAK	C	S	2
FT	#HET	124	 976 	ASN	C	12	1204 	EDO	C	B	1
FT	#HET	125	 977 	LEU	C	12	1204 	EDO	C	A	3
FT	#HET	128	 980 	GLN	C	12	1204 	EDO	C	S	7
FT	#HET	155	1007 	ARG	C	9	1201 	JAK	C	B	2
FT	#HET	156	1008 	ASN	C	9	1201 	JAK	C	S	2
FT	#HET	158	1010 	LEU	C	9	1201 	JAK	C	S	12
FT	#HET	168	1020 	GLY	C	9	1201 	JAK	C	B	2
FT	#HET	169	1021 	ASP	C	9	1201 	JAK	C	S	1
FT	#HET	185	1037 	VAL	C	13	1205 	EDO	C	S	1
FT	#HET	188	1040 	ASP	C	13	1205 	EDO	C	A	3
FT	#HET	191	1043 	SER	C	13	1205 	EDO	C	S	4
FT	#HET	196	1048 	TYR	C	13	1205 	EDO	C	S	1
FT	#HET	200	1052 	CYS	C	13	1205 	EDO	C	B	4
FT	#HET	204	1056 	SER	C	13	1205 	EDO	C	A	6
FT	#HET	206	1058 	PHE	C	13	1205 	EDO	C	S	6
FT	#HET	223	1075 	LEU	C	12	1204 	EDO	C	B	2
FT	#HET	225	1077 	TYR	C	12	1204 	EDO	C	S	4
FT	#HET	245	1097 	GLY	C	11	1203 	EDO	C	B	1
FT	#HET	246	1098 	GLN	C	11	1203 	EDO	C	A	4
FT	#HET	266	1118 	PRO	C	12	1204 	EDO	C	B	1
FT	#HET	267	1119 	ASN	C	12	1204 	EDO	C	B	1
FT	DISORDER	1	13
FT	DISORDER	61	64
FT	DISORDER	94	98
CC	SEQUENCE	280 AA (ATOM);
CC	DPTHFEKRFL KRIRDLGEGH FGKVELCRYD PEGDNTGEQV AVKSLKPNHI ADLKKEIEIL
CC	RNLYHENIVK YKGICTGIKL IMEFLPSGSL KEYLPKNKNK INLKQQLKYA VQICKGMDYL
CC	GSRQYVHRDL AARNVLVESE HQVKIGDFGL TKAIETDKEY YTVKDDRDSP VFWYAPECLM
CC	QSKFYIASDV WSFGVTLHEL LTYCDSDSSP MALFLKMIGP THGQMTVTRL VNTLKEGKRL
CC	PCPPNCPDEV YQLMRKCWEF QPSNRTSFQN LIEGFEALLK
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES GDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	ATOM   -------------DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	                    *************************************
CC	SEQRES EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGI
CC	ATOM   EQVAVKSLKP----NHIADLKKEIEILRNLYHENIVKYKGICT-----GI
CC	       **********    *****************************     **
CC	SEQRES KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	ATOM   KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	       **************************************************
CC	SEQRES DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	ATOM   DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	       **************************************************
CC	SEQRES LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	ATOM   LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	       **************************************************
CC	SEQRES RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	ATOM   RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	       **************************************************
CC	SEQRES LK
CC	ATOM   LK
CC	       **
SQ	SEQUENCE	302 AA;      MW;         CN;
	GDIVSEKKPA TEVDPTHFEK RFLKRIRDLG EGHFGKVELC RYDPEGDNTG EQVAVKSLKP
	ESGGNHIADL KKEIEILRNL YHENIVKYKG ICTEDGGNGI KLIMEFLPSG SLKEYLPKNK
	NKINLKQQLK YAVQICKGMD YLGSRQYVHR DLAARNVLVE SEHQVKIGDF GLTKAIETDK
	EYYTVKDDRD SPVFWYAPEC LMQSKFYIAS DVWSFGVTLH ELLTYCDSDS SPMALFLKMI
	GPTHGQMTVT RLVNTLKEGK RLPCPPNCPD EVYQLMRKCW EFQPSNRTSF QNLIEGFEAL
	LK
//
ID	4EHZD	STANDARD;	PRT;	302	AA.
DT	CONVERTED FROM PDB (SEQRES) 4EHZ
DE	Tyrosine-protein kinase JAK1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.170
CC	R-Factor	0.174
FT	#SUB	140	 992 	ASP	D	48	 900 	ASN	B	Protein	S	3
FT	#SUB	144	 996 	SER	D	24	 876 	LYS	B	Protein	A	2
FT	#SUB	179	1031 	ASP	D	20	 872 	LYS	B	Protein	A	5
FT	#SUB	285	1137 	SER	D	25	 877 	ARG	B	Protein	B	4
FT	#SUB	285	1137 	SER	D	28	 880 	ASP	B	Protein	B	1
FT	#SUB	287	1139 	ARG	D	25	 877 	ARG	B	Protein	B	2
FT	#SUB	289	1141 	SER	D	25	 877 	ARG	B	Protein	S	2
FT	#SUB	289	1141 	SER	D	26	 878 	ILE	B	Protein	A	7
FT	#SUB	291	1143 	GLN	D	41	 893 	ARG	B	Protein	S	3
FT	#SUB	291	1143 	GLN	D	48	 900 	ASN	B	Protein	S	6
FT	#SUB	292	1144 	ASN	D	26	 878 	ILE	B	Protein	S	1
FT	#SUB	292	1144 	ASN	D	27	 879 	ARG	B	Protein	S	1
FT	#SUB	185	1037 	VAL	D	251	1103 	ARG	C	Protein	B	1
FT	#SUB	186	1038 	LYS	D	244	1096 	HIS	C	Protein	B	2
FT	#SUB	186	1038 	LYS	D	251	1103 	ARG	C	Protein	B	2
FT	#SUB	188	1040 	ASP	D	244	1096 	HIS	C	Protein	S	5
FT	#SUB	188	1040 	ASP	D	247	1099 	MET	C	Protein	A	8
FT	#SUB	188	1040 	ASP	D	251	1103 	ARG	C	Protein	S	5
FT	#SUB	189	1041 	ARG	D	243	1095 	THR	C	Protein	S	3
FT	#SUB	189	1041 	ARG	D	244	1096 	HIS	C	Protein	A	2
FT	#SUB	189	1041 	ARG	D	245	1097 	GLY	C	Protein	S	3
FT	#SUB	191	1043 	SER	D	246	1098 	GLN	C	Protein	B	1
FT	#SUB	193	1045 	VAL	D	246	1098 	GLN	C	Protein	S	2
FT	#SUB	193	1045 	VAL	D	247	1099 	MET	C	Protein	S	1
FT	#SUB	201	1053 	LEU	D	247	1099 	MET	C	Protein	B	1
FT	#SUB	201	1053 	LEU	D	250	1102 	THR	C	Protein	B	3
FT	#SUB	202	1054 	MET	D	250	1102 	THR	C	Protein	B	3
FT	#SUB	202	1054 	MET	D	254	1106 	ASN	C	Protein	B	3
FT	#SUB	203	1055 	GLN	D	254	1106 	ASN	C	Protein	B	1
FT	#SUB	204	1056 	SER	D	251	1103 	ARG	C	Protein	S	3
FT	#SUB	243	1095 	THR	D	189	1041 	ARG	C	Protein	A	8
FT	#SUB	244	1096 	HIS	D	186	1038 	LYS	C	Protein	S	2
FT	#SUB	244	1096 	HIS	D	188	1040 	ASP	C	Protein	A	7
FT	#SUB	244	1096 	HIS	D	189	1041 	ARG	C	Protein	B	2
FT	#SUB	246	1098 	GLN	D	189	1041 	ARG	C	Protein	S	1
FT	#SUB	246	1098 	GLN	D	191	1043 	SER	C	Protein	S	2
FT	#SUB	246	1098 	GLN	D	193	1045 	VAL	C	Protein	S	1
FT	#SUB	246	1098 	GLN	D	249	1101 	VAL	C	Protein	B	1
FT	#SUB	247	1099 	MET	D	188	1040 	ASP	C	Protein	S	7
FT	#SUB	247	1099 	MET	D	193	1045 	VAL	C	Protein	S	1
FT	#SUB	247	1099 	MET	D	201	1053 	LEU	C	Protein	S	1
FT	#SUB	249	1101 	VAL	D	246	1098 	GLN	C	Protein	S	2
FT	#SUB	249	1101 	VAL	D	250	1102 	THR	C	Protein	S	1
FT	#SUB	250	1102 	THR	D	201	1053 	LEU	C	Protein	S	3
FT	#SUB	250	1102 	THR	D	202	1054 	MET	C	Protein	S	3
FT	#SUB	250	1102 	THR	D	249	1101 	VAL	C	Protein	S	1
FT	#SUB	251	1103 	ARG	D	185	1037 	VAL	C	Protein	S	2
FT	#SUB	251	1103 	ARG	D	186	1038 	LYS	C	Protein	S	1
FT	#SUB	251	1103 	ARG	D	188	1040 	ASP	C	Protein	S	4
FT	#SUB	251	1103 	ARG	D	204	1056 	SER	C	Protein	S	1
FT	#SUB	254	1106 	ASN	D	202	1054 	MET	C	Protein	S	4
FT	#HET	27	 879 	ARG	D	15	1202 	EDO	D	S	2
FT	#HET	29	 881 	LEU	D	14	1201 	JAK	D	A	9
FT	#HET	29	 881 	LEU	D	15	1202 	EDO	D	S	1
FT	#HET	37	 889 	VAL	D	14	1201 	JAK	D	S	5
FT	#HET	54	 906 	ALA	D	14	1201 	JAK	D	S	3
FT	#HET	104	 956 	MET	D	14	1201 	JAK	D	S	2
FT	#HET	105	 957 	GLU	D	14	1201 	JAK	D	B	3
FT	#HET	106	 958 	PHE	D	14	1201 	JAK	D	A	5
FT	#HET	106	 958 	PHE	D	15	1202 	EDO	D	S	1
FT	#HET	107	 959 	LEU	D	14	1201 	JAK	D	B	4
FT	#HET	108	 960 	PRO	D	15	1202 	EDO	D	B	3
FT	#HET	110	 962 	GLY	D	14	1201 	JAK	D	B	1
FT	#HET	110	 962 	GLY	D	15	1202 	EDO	D	B	6
FT	#HET	111	 963 	SER	D	14	1201 	JAK	D	B	1
FT	#HET	114	 966 	GLU	D	14	1201 	JAK	D	S	2
FT	#HET	114	 966 	GLU	D	15	1202 	EDO	D	S	1
FT	#HET	117	 969 	PRO	D	16	1203 	EDO	D	B	2
FT	#HET	118	 970 	LYS	D	16	1203 	EDO	D	B	8
FT	#HET	119	 971 	ASN	D	16	1203 	EDO	D	B	6
FT	#HET	120	 972 	LYS	D	16	1203 	EDO	D	A	8
FT	#HET	121	 973 	ASN	D	16	1203 	EDO	D	A	5
FT	#HET	155	1007 	ARG	D	14	1201 	JAK	D	B	2
FT	#HET	156	1008 	ASN	D	14	1201 	JAK	D	S	2
FT	#HET	158	1010 	LEU	D	14	1201 	JAK	D	S	10
FT	#HET	168	1020 	GLY	D	14	1201 	JAK	D	B	2
FT	#HET	169	1021 	ASP	D	14	1201 	JAK	D	S	2
FT	#HET	245	1097 	GLY	D	11	1203 	EDO	C	B	2
FT	#HET	246	1098 	GLN	D	11	1203 	EDO	C	A	2
FT	#HET	247	1099 	MET	D	13	1205 	EDO	C	S	1
FT	DISORDER	1	12
FT	DISORDER	61	64
FT	DISORDER	94	97
CC	SEQUENCE	282 AA (ATOM);
CC	VDPTHFEKRF LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ VAVKSLKPNH IADLKKEIEI
CC	LRNLYHENIV KYKGICTNGI KLIMEFLPSG SLKEYLPKNK NKINLKQQLK YAVQICKGMD
CC	YLGSRQYVHR DLAARNVLVE SEHQVKIGDF GLTKAIETDK EYYTVKDDRD SPVFWYAPEC
CC	LMQSKFYIAS DVWSFGVTLH ELLTYCDSDS SPMALFLKMI GPTHGQMTVT RLVNTLKEGK
CC	RLPCPPNCPD EVYQLMRKCW EFQPSNRTSF QNLIEGFEAL LK
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES GDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	ATOM   ------------VDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	                   **************************************
CC	SEQRES EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGI
CC	ATOM   EQVAVKSLKP----NHIADLKKEIEILRNLYHENIVKYKGICT----NGI
CC	       **********    *****************************    ***
CC	SEQRES KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	ATOM   KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	       **************************************************
CC	SEQRES DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	ATOM   DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	       **************************************************
CC	SEQRES LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	ATOM   LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	       **************************************************
CC	SEQRES RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	ATOM   RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	       **************************************************
CC	SEQRES LK
CC	ATOM   LK
CC	       **
SQ	SEQUENCE	302 AA;      MW;         CN;
	GDIVSEKKPA TEVDPTHFEK RFLKRIRDLG EGHFGKVELC RYDPEGDNTG EQVAVKSLKP
	ESGGNHIADL KKEIEILRNL YHENIVKYKG ICTEDGGNGI KLIMEFLPSG SLKEYLPKNK
	NKINLKQQLK YAVQICKGMD YLGSRQYVHR DLAARNVLVE SEHQVKIGDF GLTKAIETDK
	EYYTVKDDRD SPVFWYAPEC LMQSKFYIAS DVWSFGVTLH ELLTYCDSDS SPMALFLKMI
	GPTHGQMTVT RLVNTLKEGK RLPCPPNCPD EVYQLMRKCW EFQPSNRTSF QNLIEGFEAL
	LK
//