ID	4EAWA	STANDARD;	PRT;	562	AA.
DT	CONVERTED FROM PDB (SEQRES) 4EAW
DE	RNA-directed RNA polymerase
OS	Hepatitis C virus subtype 1b
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.000
CC	R-Factor	0.173
FT	#SUB	57	  57 	LEU	A	2	   2 	MET	B	Protein	S	1
FT	#SUB	57	  57 	LEU	A	53	  53 	THR	B	Protein	S	2
FT	#SUB	59	  59 	VAL	A	2	   2 	MET	B	Protein	S	1
FT	#SUB	337	 337 	ARG	A	8	   8 	GLY	B	Protein	A	7
FT	#SUB	337	 337 	ARG	A	10	  10 	LEU	B	Protein	S	1
FT	#SUB	338	 338 	ALA	A	7	   7 	THR	B	Protein	A	3
FT	#SUB	341	 341 	GLU	A	6	   6 	TRP	B	Protein	S	4
FT	#SUB	341	 341 	GLU	A	8	   8 	GLY	B	Protein	S	2
FT	#SUB	345	 345 	ARG	A	6	   6 	TRP	B	Protein	S	1
FT	#HET	4	   4 	TYR	A	9	609 	PEG	A	S	3
FT	#HET	48	  48 	ARG	A	3	603 	SO4	A	S	8
FT	#HET	48	  48 	ARG	A	9	609 	PEG	A	S	3
FT	#HET	60	  60 	LEU	A	6	606 	SO4	A	S	1
FT	#HET	64	  64 	TYR	A	6	606 	SO4	A	S	1
FT	#HET	65	  65 	ARG	A	6	606 	SO4	A	S	3
FT	#HET	68	  68 	LEU	A	6	606 	SO4	A	S	1
FT	#HET	79	  79 	LYS	A	10	610 	EDO	A	S	3
FT	#HET	82	  82 	LEU	A	11	611 	EDO	A	S	2
FT	#HET	83	  83 	LEU	A	11	611 	EDO	A	B	2
FT	#HET	84	  84 	SER	A	11	611 	EDO	A	B	1
FT	#HET	85	  85 	ILE	A	11	611 	EDO	A	S	1
FT	#HET	123	 123 	TRP	A	11	611 	EDO	A	S	1
FT	#HET	143	 143 	GLU	A	8	608 	PEG	A	S	1
FT	#HET	145	 145 	PHE	A	8	608 	PEG	A	S	1
FT	#HET	155	 155 	LYS	A	8	608 	PEG	A	S	1
FT	#HET	159	 159 	LEU	A	9	609 	PEG	A	B	5
FT	#HET	161	 161 	VAL	A	9	609 	PEG	A	S	4
FT	#HET	173	 173 	MET	A	11	611 	EDO	A	S	1
FT	#HET	193	 193 	PHE	A	1	601 	0NQ	A	S	2
FT	#HET	200	 200 	ARG	A	1	601 	0NQ	A	S	4
FT	#HET	222	 222 	ARG	A	3	603 	SO4	A	B	2
FT	#HET	223	 223 	CYS	A	3	603 	SO4	A	A	7
FT	#HET	225	 225 	ASP	A	9	609 	PEG	A	S	4
FT	#HET	244	 244 	ASP	A	10	610 	EDO	A	S	3
FT	#HET	280	 280 	ARG	A	9	609 	PEG	A	B	2
FT	#HET	281	 281 	ALA	A	9	609 	PEG	A	B	2
FT	#HET	282	 282 	SER	A	9	609 	PEG	A	A	7
FT	#HET	288	 288 	SER	A	1	601 	0NQ	A	A	3
FT	#HET	291	 291 	ASN	A	1	601 	0NQ	A	S	3
FT	#HET	316	 316 	TYR	A	1	601 	0NQ	A	B	3
FT	#HET	317	 317 	GLY	A	1	601 	0NQ	A	B	3
FT	#HET	318	 318 	ASP	A	1	601 	0NQ	A	A	9
FT	#HET	366	 366 	CYS	A	1	601 	0NQ	A	S	3
FT	#HET	368	 368 	SER	A	1	601 	0NQ	A	S	2
FT	#HET	384	 384 	LEU	A	1	601 	0NQ	A	S	1
FT	#HET	386	 386 	ARG	A	8	608 	PEG	A	S	5
FT	#HET	390	 390 	THR	A	8	608 	PEG	A	S	5
FT	#HET	394	 394 	ARG	A	8	608 	PEG	A	S	7
FT	#HET	410	 410 	GLY	A	1	601 	0NQ	A	B	1
FT	#HET	411	 411 	ASN	A	1	601 	0NQ	A	S	1
FT	#HET	414	 414 	MET	A	1	601 	0NQ	A	A	2
FT	#HET	415	 415 	TYR	A	1	601 	0NQ	A	S	4
FT	#HET	423	 423 	MET	A	7	607 	SO4	A	S	2
FT	#HET	446	 446 	GLN	A	1	601 	0NQ	A	B	2
FT	#HET	447	 447 	ILE	A	1	601 	0NQ	A	B	2
FT	#HET	448	 448 	TYR	A	1	601 	0NQ	A	A	15
FT	#HET	449	 449 	GLY	A	1	601 	0NQ	A	B	6
FT	#HET	474	 474 	LEU	A	7	607 	SO4	A	B	1
FT	#HET	475	 475 	HIS	A	5	605 	SO4	A	A	7
FT	#HET	475	 475 	HIS	A	7	607 	SO4	A	A	2
FT	#HET	476	 476 	SER	A	5	605 	SO4	A	B	4
FT	#HET	477	 477 	TYR	A	7	607 	SO4	A	S	5
FT	#HET	505	 505 	ARG	A	2	602 	SO4	A	S	8
FT	#HET	516	 516 	GLY	A	4	604 	SO4	A	B	2
FT	#HET	517	 517 	ARG	A	4	604 	SO4	A	A	13
FT	#HET	528	 528 	TRP	A	7	607 	SO4	A	S	1
FT	#HET	530	 530 	VAL	A	2	602 	SO4	A	A	3
FT	#HET	531	 531 	ARG	A	2	602 	SO4	A	A	8
FT	#HET	532	 532 	THR	A	2	602 	SO4	A	A	5
FT	#HET	556	 556 	SER	A	1	601 	0NQ	A	S	7
FT	DISORDER	150	152
CC	SEQUENCE	559 AA (ATOM);
CC	SMSYTWTGAL ITPCAAEESK LPINPLSNSL LRHHNMVYAT TSRSASLRQK KVTFDRLQVL
CC	DDHYRDVLKE MKAKASTVKA KLLSIEEACK LTPPHSAKSK FGYGAKDVRN LSSRAVNHIR
CC	SVWEDLLEDT ETPIDTTIMA KSEVFCVQPG RKPARLIVFP DLGVRVCEKM ALYDVVSTLP
CC	QAVMGSSYGF QYSPKQRVEF LVNTWKSKKC PMGFSYDTRC FDSTVTESDI RVEESIYQCC
CC	DLAPEARQAI RSLTERLYIG GPLTNSKGQN CGYRRCRASG VLTTSCGNTL TCYLKATAAC
CC	RAAKLQDCTM LVYGDDLVVI CESAGTQEDA AALRAFTEAM TRYSAPPGDP PQPEYDLELI
CC	TSCSSNVSVA HDASGKRVYY LTRDPTTPLA RAAWETARHT PINSWLGNII MYAPTLWARM
CC	ILMTHFFSIL LAQEQLEKAL DCQIYGACYS IEPLDLPQII ERLHGLSAFT LHSYSPGEIN
CC	RVASCLRKLG VPPLRTWRHR ARSVRAKLLS QGGRAATCGR YLFNWAVRTK LKLTPIPAAS
CC	QLDLSGWFVA GYSGGDIYH
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHNMVYATTSRSASLRQK
CC	ATOM   SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHNMVYATTSRSASLRQK
CC	       **************************************************
CC	SEQRES KVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSIEEACKLTPPHSAKSK
CC	ATOM   KVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSIEEACKLTPPHSAKSK
CC	       **************************************************
CC	SEQRES FGYGAKDVRNLSSRAVNHIRSVWEDLLEDTETPIDTTIMAKSEVFCVQPE
CC	ATOM   FGYGAKDVRNLSSRAVNHIRSVWEDLLEDTETPIDTTIMAKSEVFCVQP-
CC	       ************************************************* 
CC	SEQRES KGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQR
CC	ATOM   --GRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQR
CC	         ************************************************
CC	SEQRES VEFLVNTWKSKKCPMGFSYDTRCFDSTVTESDIRVEESIYQCCDLAPEAR
CC	ATOM   VEFLVNTWKSKKCPMGFSYDTRCFDSTVTESDIRVEESIYQCCDLAPEAR
CC	       **************************************************
CC	SEQRES QAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAT
CC	ATOM   QAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAT
CC	       **************************************************
CC	SEQRES AACRAAKLQDCTMLVYGDDLVVICESAGTQEDAAALRAFTEAMTRYSAPP
CC	ATOM   AACRAAKLQDCTMLVYGDDLVVICESAGTQEDAAALRAFTEAMTRYSAPP
CC	       **************************************************
CC	SEQRES GDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETA
CC	ATOM   GDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETA
CC	       **************************************************
CC	SEQRES RHTPINSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGA
CC	ATOM   RHTPINSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGA
CC	       **************************************************
CC	SEQRES CYSIEPLDLPQIIERLHGLSAFTLHSYSPGEINRVASCLRKLGVPPLRTW
CC	ATOM   CYSIEPLDLPQIIERLHGLSAFTLHSYSPGEINRVASCLRKLGVPPLRTW
CC	       **************************************************
CC	SEQRES RHRARSVRAKLLSQGGRAATCGRYLFNWAVRTKLKLTPIPAASQLDLSGW
CC	ATOM   RHRARSVRAKLLSQGGRAATCGRYLFNWAVRTKLKLTPIPAASQLDLSGW
CC	       **************************************************
CC	SEQRES FVAGYSGGDIYH
CC	ATOM   FVAGYSGGDIYH
CC	       ************
SQ	SEQUENCE	562 AA;      MW;         CN;
	SMSYTWTGAL ITPCAAEESK LPINPLSNSL LRHHNMVYAT TSRSASLRQK KVTFDRLQVL
	DDHYRDVLKE MKAKASTVKA KLLSIEEACK LTPPHSAKSK FGYGAKDVRN LSSRAVNHIR
	SVWEDLLEDT ETPIDTTIMA KSEVFCVQPE KGGRKPARLI VFPDLGVRVC EKMALYDVVS
	TLPQAVMGSS YGFQYSPKQR VEFLVNTWKS KKCPMGFSYD TRCFDSTVTE SDIRVEESIY
	QCCDLAPEAR QAIRSLTERL YIGGPLTNSK GQNCGYRRCR ASGVLTTSCG NTLTCYLKAT
	AACRAAKLQD CTMLVYGDDL VVICESAGTQ EDAAALRAFT EAMTRYSAPP GDPPQPEYDL
	ELITSCSSNV SVAHDASGKR VYYLTRDPTT PLARAAWETA RHTPINSWLG NIIMYAPTLW
	ARMILMTHFF SILLAQEQLE KALDCQIYGA CYSIEPLDLP QIIERLHGLS AFTLHSYSPG
	EINRVASCLR KLGVPPLRTW RHRARSVRAK LLSQGGRAAT CGRYLFNWAV RTKLKLTPIP
	AASQLDLSGW FVAGYSGGDI YH
//
ID	4EAWB	STANDARD;	PRT;	562	AA.
DT	CONVERTED FROM PDB (SEQRES) 4EAW
DE	RNA-directed RNA polymerase
OS	Hepatitis C virus subtype 1b
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.000
CC	R-Factor	0.173
FT	#SUB	2	   2 	MET	B	57	  57 	LEU	A	Protein	S	1
FT	#SUB	2	   2 	MET	B	59	  59 	VAL	A	Protein	S	1
FT	#SUB	6	   6 	TRP	B	341	 341 	GLU	A	Protein	A	4
FT	#SUB	6	   6 	TRP	B	345	 345 	ARG	A	Protein	B	1
FT	#SUB	7	   7 	THR	B	338	 338 	ALA	A	Protein	B	3
FT	#SUB	8	   8 	GLY	B	337	 337 	ARG	A	Protein	B	7
FT	#SUB	8	   8 	GLY	B	341	 341 	GLU	A	Protein	B	2
FT	#SUB	10	  10 	LEU	B	337	 337 	ARG	A	Protein	S	1
FT	#SUB	53	  53 	THR	B	57	  57 	LEU	A	Protein	A	2
FT	#HET	48	  48 	ARG	B	14	603 	SO4	B	S	8
FT	#HET	51	  51 	LYS	B	14	603 	SO4	B	S	1
FT	#HET	114	 114 	ARG	B	13	602 	SO4	B	S	8
FT	#HET	143	 143 	GLU	B	15	604 	PEG	B	S	1
FT	#HET	155	 155 	LYS	B	15	604 	PEG	B	S	1
FT	#HET	193	 193 	PHE	B	12	601 	0NQ	B	S	1
FT	#HET	200	 200 	ARG	B	12	601 	0NQ	B	S	5
FT	#HET	222	 222 	ARG	B	14	603 	SO4	B	B	2
FT	#HET	223	 223 	CYS	B	14	603 	SO4	B	A	7
FT	#HET	288	 288 	SER	B	12	601 	0NQ	B	A	3
FT	#HET	291	 291 	ASN	B	12	601 	0NQ	B	S	3
FT	#HET	316	 316 	TYR	B	12	601 	0NQ	B	B	3
FT	#HET	317	 317 	GLY	B	12	601 	0NQ	B	B	3
FT	#HET	318	 318 	ASP	B	12	601 	0NQ	B	A	6
FT	#HET	366	 366 	CYS	B	12	601 	0NQ	B	S	2
FT	#HET	368	 368 	SER	B	12	601 	0NQ	B	S	2
FT	#HET	384	 384 	LEU	B	12	601 	0NQ	B	S	1
FT	#HET	386	 386 	ARG	B	15	604 	PEG	B	S	7
FT	#HET	390	 390 	THR	B	15	604 	PEG	B	S	4
FT	#HET	394	 394 	ARG	B	15	604 	PEG	B	S	6
FT	#HET	410	 410 	GLY	B	12	601 	0NQ	B	B	2
FT	#HET	411	 411 	ASN	B	12	601 	0NQ	B	S	1
FT	#HET	414	 414 	MET	B	12	601 	0NQ	B	A	4
FT	#HET	415	 415 	TYR	B	12	601 	0NQ	B	S	5
FT	#HET	446	 446 	GLN	B	12	601 	0NQ	B	B	2
FT	#HET	447	 447 	ILE	B	12	601 	0NQ	B	B	2
FT	#HET	448	 448 	TYR	B	12	601 	0NQ	B	A	13
FT	#HET	449	 449 	GLY	B	12	601 	0NQ	B	B	6
FT	#HET	556	 556 	SER	B	12	601 	0NQ	B	S	8
FT	DISORDER	150	152
CC	SEQUENCE	559 AA (ATOM);
CC	SMSYTWTGAL ITPCAAEESK LPINPLSNSL LRHHNMVYAT TSRSASLRQK KVTFDRLQVL
CC	DDHYRDVLKE MKAKASTVKA KLLSIEEACK LTPPHSAKSK FGYGAKDVRN LSSRAVNHIR
CC	SVWEDLLEDT ETPIDTTIMA KSEVFCVQPG RKPARLIVFP DLGVRVCEKM ALYDVVSTLP
CC	QAVMGSSYGF QYSPKQRVEF LVNTWKSKKC PMGFSYDTRC FDSTVTESDI RVEESIYQCC
CC	DLAPEARQAI RSLTERLYIG GPLTNSKGQN CGYRRCRASG VLTTSCGNTL TCYLKATAAC
CC	RAAKLQDCTM LVYGDDLVVI CESAGTQEDA AALRAFTEAM TRYSAPPGDP PQPEYDLELI
CC	TSCSSNVSVA HDASGKRVYY LTRDPTTPLA RAAWETARHT PINSWLGNII MYAPTLWARM
CC	ILMTHFFSIL LAQEQLEKAL DCQIYGACYS IEPLDLPQII ERLHGLSAFT LHSYSPGEIN
CC	RVASCLRKLG VPPLRTWRHR ARSVRAKLLS QGGRAATCGR YLFNWAVRTK LKLTPIPAAS
CC	QLDLSGWFVA GYSGGDIYH
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHNMVYATTSRSASLRQK
CC	ATOM   SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHNMVYATTSRSASLRQK
CC	       **************************************************
CC	SEQRES KVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSIEEACKLTPPHSAKSK
CC	ATOM   KVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSIEEACKLTPPHSAKSK
CC	       **************************************************
CC	SEQRES FGYGAKDVRNLSSRAVNHIRSVWEDLLEDTETPIDTTIMAKSEVFCVQPE
CC	ATOM   FGYGAKDVRNLSSRAVNHIRSVWEDLLEDTETPIDTTIMAKSEVFCVQP-
CC	       ************************************************* 
CC	SEQRES KGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQR
CC	ATOM   --GRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQR
CC	         ************************************************
CC	SEQRES VEFLVNTWKSKKCPMGFSYDTRCFDSTVTESDIRVEESIYQCCDLAPEAR
CC	ATOM   VEFLVNTWKSKKCPMGFSYDTRCFDSTVTESDIRVEESIYQCCDLAPEAR
CC	       **************************************************
CC	SEQRES QAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAT
CC	ATOM   QAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAT
CC	       **************************************************
CC	SEQRES AACRAAKLQDCTMLVYGDDLVVICESAGTQEDAAALRAFTEAMTRYSAPP
CC	ATOM   AACRAAKLQDCTMLVYGDDLVVICESAGTQEDAAALRAFTEAMTRYSAPP
CC	       **************************************************
CC	SEQRES GDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETA
CC	ATOM   GDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETA
CC	       **************************************************
CC	SEQRES RHTPINSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGA
CC	ATOM   RHTPINSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGA
CC	       **************************************************
CC	SEQRES CYSIEPLDLPQIIERLHGLSAFTLHSYSPGEINRVASCLRKLGVPPLRTW
CC	ATOM   CYSIEPLDLPQIIERLHGLSAFTLHSYSPGEINRVASCLRKLGVPPLRTW
CC	       **************************************************
CC	SEQRES RHRARSVRAKLLSQGGRAATCGRYLFNWAVRTKLKLTPIPAASQLDLSGW
CC	ATOM   RHRARSVRAKLLSQGGRAATCGRYLFNWAVRTKLKLTPIPAASQLDLSGW
CC	       **************************************************
CC	SEQRES FVAGYSGGDIYH
CC	ATOM   FVAGYSGGDIYH
CC	       ************
SQ	SEQUENCE	562 AA;      MW;         CN;
	SMSYTWTGAL ITPCAAEESK LPINPLSNSL LRHHNMVYAT TSRSASLRQK KVTFDRLQVL
	DDHYRDVLKE MKAKASTVKA KLLSIEEACK LTPPHSAKSK FGYGAKDVRN LSSRAVNHIR
	SVWEDLLEDT ETPIDTTIMA KSEVFCVQPE KGGRKPARLI VFPDLGVRVC EKMALYDVVS
	TLPQAVMGSS YGFQYSPKQR VEFLVNTWKS KKCPMGFSYD TRCFDSTVTE SDIRVEESIY
	QCCDLAPEAR QAIRSLTERL YIGGPLTNSK GQNCGYRRCR ASGVLTTSCG NTLTCYLKAT
	AACRAAKLQD CTMLVYGDDL VVICESAGTQ EDAAALRAFT EAMTRYSAPP GDPPQPEYDL
	ELITSCSSNV SVAHDASGKR VYYLTRDPTT PLARAAWETA RHTPINSWLG NIIMYAPTLW
	ARMILMTHFF SILLAQEQLE KALDCQIYGA CYSIEPLDLP QIIERLHGLS AFTLHSYSPG
	EINRVASCLR KLGVPPLRTW RHRARSVRAK LLSQGGRAAT CGRYLFNWAV RTKLKLTPIP
	AASQLDLSGW FVAGYSGGDI YH
//