ID	4E6DA	STANDARD;	PRT;	298	AA.
DT	CONVERTED FROM PDB (SEQRES) 4E6D
DE	Tyrosine-protein kinase JAK2
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.220
CC	R-Factor	0.162
FT	#SUB	137	 971 	ARG	A	23	 857 	LYS	B	Protein	S	1
FT	#SUB	172	1006 	GLU	A	23	 857 	LYS	B	Protein	S	4
FT	#SUB	277	1111 	ASN	A	17	 851 	PHE	B	Protein	S	11
FT	#SUB	277	1111 	ASN	A	30	 864 	GLU	B	Protein	A	7
FT	#SUB	277	1111 	ASN	A	49	 883 	LYS	B	Protein	B	2
FT	#SUB	278	1112 	GLN	A	12	 846 	GLU	B	Protein	S	1
FT	#SUB	281	1115 	SER	A	51	 885 	GLN	B	Protein	S	3
FT	#SUB	283	1117 	ARG	A	25	 859 	ASN	B	Protein	S	4
FT	#SUB	283	1117 	ARG	A	26	 860 	PHE	B	Protein	S	1
FT	#SUB	283	1117 	ARG	A	51	 885 	GLN	B	Protein	S	4
FT	#SUB	283	1117 	ARG	A	52	 886 	HIS	B	Protein	S	2
FT	#SUB	284	1118 	ASP	A	51	 885 	GLN	B	Protein	S	3
FT	#SUB	284	1118 	ASP	A	52	 886 	HIS	B	Protein	S	3
FT	#SUB	284	1118 	ASP	A	53	 887 	SER	B	Protein	S	9
FT	#SUB	287	1121 	LEU	A	52	 886 	HIS	B	Protein	S	1
FT	#SUB	287	1121 	LEU	A	53	 887 	SER	B	Protein	S	2
FT	#SUB	287	1121 	LEU	A	54	 888 	THR	B	Protein	S	2
FT	#HET	21	 855 	LEU	A	1	1201 	0NU	A	A	13
FT	#HET	22	 856 	GLY	A	1	1201 	0NU	A	B	10
FT	#HET	23	 857 	LYS	A	1	1201 	0NU	A	B	7
FT	#HET	24	 858 	GLY	A	1	1201 	0NU	A	B	3
FT	#HET	27	 861 	GLY	A	1	1201 	0NU	A	B	3
FT	#HET	28	 862 	SER	A	1	1201 	0NU	A	B	3
FT	#HET	29	 863 	VAL	A	1	1201 	0NU	A	A	15
FT	#HET	46	 880 	ALA	A	1	1201 	0NU	A	S	5
FT	#HET	48	 882 	LYS	A	1	1201 	0NU	A	S	1
FT	#HET	77	 911 	VAL	A	1	1201 	0NU	A	S	4
FT	#HET	95	 929 	MET	A	1	1201 	0NU	A	S	7
FT	#HET	96	 930 	GLU	A	1	1201 	0NU	A	B	7
FT	#HET	97	 931 	PHE	A	1	1201 	0NU	A	A	10
FT	#HET	98	 932 	LEU	A	1	1201 	0NU	A	B	11
FT	#HET	101	 935 	GLY	A	1	1201 	0NU	A	B	2
FT	#HET	146	 980 	ARG	A	1	1201 	0NU	A	B	4
FT	#HET	147	 981 	ASN	A	1	1201 	0NU	A	A	8
FT	#HET	149	 983 	LEU	A	1	1201 	0NU	A	S	18
FT	#HET	159	 993 	GLY	A	1	1201 	0NU	A	B	9
FT	#HET	160	 994 	ASP	A	1	1201 	0NU	A	S	13
FT	DISORDER	1	5
FT	DISORDER	85	89
CC	SEQUENCE	288 AA (ATOM);
CC	DPTQFEERHL KFLRQLGKGN FGSVEMCRYD PLQDNTGEVV AVKKLQHSTE EHLRDFEREI
CC	EILKSLQHDN IVKYKGVCYN LKLIMEFLPY GSLREYLQKH KERIDHIKLL QYTSQICKGM
CC	EYLGTKRYIH RDLATRNILV ENENRVKIGD FGLTKVLPQD KEYYKVKEPG ESPIFWYAPE
CC	SLTESKFSVA SDVWSFGVVL YELFTYIEKS KSPPAEFMRM IGNDKQGQMI VFHLIELLKN
CC	NGRLPRPDGC PDEIYMIMTE CWNNNVNQRP SFRDLALRVD QIRDNMAG
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES AFEDRDPTQFEERHLKFLRQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL
CC	ATOM   -----DPTQFEERHLKFLRQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL
CC	            *********************************************
CC	SEQRES QHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEFLPY
CC	ATOM   QHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCY-----NLKLIMEFLPY
CC	       **********************************     ***********
CC	SEQRES GSLREYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILV
CC	ATOM   GSLREYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILV
CC	       **************************************************
CC	SEQRES ENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVA
CC	ATOM   ENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVA
CC	       **************************************************
CC	SEQRES SDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKN
CC	ATOM   SDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKN
CC	       **************************************************
CC	SEQRES NGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
CC	ATOM   NGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
CC	       ************************************************
SQ	SEQUENCE	298 AA;      MW;         CN;
	AFEDRDPTQF EERHLKFLRQ LGKGNFGSVE MCRYDPLQDN TGEVVAVKKL QHSTEEHLRD
	FEREIEILKS LQHDNIVKYK GVCYSAGRRN LKLIMEFLPY GSLREYLQKH KERIDHIKLL
	QYTSQICKGM EYLGTKRYIH RDLATRNILV ENENRVKIGD FGLTKVLPQD KEYYKVKEPG
	ESPIFWYAPE SLTESKFSVA SDVWSFGVVL YELFTYIEKS KSPPAEFMRM IGNDKQGQMI
	VFHLIELLKN NGRLPRPDGC PDEIYMIMTE CWNNNVNQRP SFRDLALRVD QIRDNMAG
//
ID	4E6DB	STANDARD;	PRT;	298	AA.
DT	CONVERTED FROM PDB (SEQRES) 4E6D
DE	Tyrosine-protein kinase JAK2
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.220
CC	R-Factor	0.162
FT	#SUB	12	 846 	GLU	B	278	1112 	GLN	A	Protein	S	1
FT	#SUB	17	 851 	PHE	B	277	1111 	ASN	A	Protein	S	11
FT	#SUB	23	 857 	LYS	B	137	 971 	ARG	A	Protein	S	1
FT	#SUB	23	 857 	LYS	B	172	1006 	GLU	A	Protein	S	4
FT	#SUB	25	 859 	ASN	B	283	1117 	ARG	A	Protein	B	4
FT	#SUB	26	 860 	PHE	B	283	1117 	ARG	A	Protein	B	1
FT	#SUB	30	 864 	GLU	B	277	1111 	ASN	A	Protein	S	7
FT	#SUB	49	 883 	LYS	B	277	1111 	ASN	A	Protein	S	2
FT	#SUB	51	 885 	GLN	B	281	1115 	SER	A	Protein	B	3
FT	#SUB	51	 885 	GLN	B	283	1117 	ARG	A	Protein	A	4
FT	#SUB	51	 885 	GLN	B	284	1118 	ASP	A	Protein	B	3
FT	#SUB	52	 886 	HIS	B	283	1117 	ARG	A	Protein	S	2
FT	#SUB	52	 886 	HIS	B	284	1118 	ASP	A	Protein	B	3
FT	#SUB	52	 886 	HIS	B	287	1121 	LEU	A	Protein	S	1
FT	#SUB	53	 887 	SER	B	284	1118 	ASP	A	Protein	A	9
FT	#SUB	53	 887 	SER	B	287	1121 	LEU	A	Protein	B	2
FT	#SUB	54	 888 	THR	B	287	1121 	LEU	A	Protein	B	2
FT	#HET	21	 855 	LEU	B	2	1201 	0NU	B	A	7
FT	#HET	22	 856 	GLY	B	2	1201 	0NU	B	B	8
FT	#HET	23	 857 	LYS	B	2	1201 	0NU	B	B	12
FT	#HET	24	 858 	GLY	B	2	1201 	0NU	B	B	7
FT	#HET	25	 859 	ASN	B	3	1202 	GOL	B	B	1
FT	#HET	26	 860 	PHE	B	3	1202 	GOL	B	A	12
FT	#HET	27	 861 	GLY	B	2	1201 	0NU	B	B	2
FT	#HET	27	 861 	GLY	B	3	1202 	GOL	B	B	1
FT	#HET	28	 862 	SER	B	2	1201 	0NU	B	B	3
FT	#HET	29	 863 	VAL	B	2	1201 	0NU	B	A	13
FT	#HET	46	 880 	ALA	B	2	1201 	0NU	B	S	5
FT	#HET	48	 882 	LYS	B	2	1201 	0NU	B	S	1
FT	#HET	48	 882 	LYS	B	3	1202 	GOL	B	S	7
FT	#HET	64	 898 	GLU	B	3	1202 	GOL	B	S	2
FT	#HET	77	 911 	VAL	B	2	1201 	0NU	B	S	3
FT	#HET	95	 929 	MET	B	2	1201 	0NU	B	S	7
FT	#HET	96	 930 	GLU	B	2	1201 	0NU	B	B	6
FT	#HET	97	 931 	PHE	B	2	1201 	0NU	B	A	10
FT	#HET	98	 932 	LEU	B	2	1201 	0NU	B	B	12
FT	#HET	101	 935 	GLY	B	2	1201 	0NU	B	B	2
FT	#HET	146	 980 	ARG	B	2	1201 	0NU	B	B	3
FT	#HET	147	 981 	ASN	B	2	1201 	0NU	B	A	7
FT	#HET	149	 983 	LEU	B	2	1201 	0NU	B	S	17
FT	#HET	159	 993 	GLY	B	2	1201 	0NU	B	B	10
FT	#HET	160	 994 	ASP	B	2	1201 	0NU	B	S	9
FT	#HET	160	 994 	ASP	B	3	1202 	GOL	B	S	5
FT	#HET	162	 996 	GLY	B	3	1202 	GOL	B	B	6
FT	DISORDER	1	5
FT	DISORDER	85	89
CC	SEQUENCE	288 AA (ATOM);
CC	DPTQFEERHL KFLRQLGKGN FGSVEMCRYD PLQDNTGEVV AVKKLQHSTE EHLRDFEREI
CC	EILKSLQHDN IVKYKGVCYN LKLIMEFLPY GSLREYLQKH KERIDHIKLL QYTSQICKGM
CC	EYLGTKRYIH RDLATRNILV ENENRVKIGD FGLTKVLPQD KEYYKVKEPG ESPIFWYAPE
CC	SLTESKFSVA SDVWSFGVVL YELFTYIEKS KSPPAEFMRM IGNDKQGQMI VFHLIELLKN
CC	NGRLPRPDGC PDEIYMIMTE CWNNNVNQRP SFRDLALRVD QIRDNMAG
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES AFEDRDPTQFEERHLKFLRQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL
CC	ATOM   -----DPTQFEERHLKFLRQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL
CC	            *********************************************
CC	SEQRES QHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEFLPY
CC	ATOM   QHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCY-----NLKLIMEFLPY
CC	       **********************************     ***********
CC	SEQRES GSLREYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILV
CC	ATOM   GSLREYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILV
CC	       **************************************************
CC	SEQRES ENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVA
CC	ATOM   ENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVA
CC	       **************************************************
CC	SEQRES SDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKN
CC	ATOM   SDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKN
CC	       **************************************************
CC	SEQRES NGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
CC	ATOM   NGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
CC	       ************************************************
SQ	SEQUENCE	298 AA;      MW;         CN;
	AFEDRDPTQF EERHLKFLRQ LGKGNFGSVE MCRYDPLQDN TGEVVAVKKL QHSTEEHLRD
	FEREIEILKS LQHDNIVKYK GVCYSAGRRN LKLIMEFLPY GSLREYLQKH KERIDHIKLL
	QYTSQICKGM EYLGTKRYIH RDLATRNILV ENENRVKIGD FGLTKVLPQD KEYYKVKEPG
	ESPIFWYAPE SLTESKFSVA SDVWSFGVVL YELFTYIEKS KSPPAEFMRM IGNDKQGQMI
	VFHLIELLKN NGRLPRPDGC PDEIYMIMTE CWNNNVNQRP SFRDLALRVD QIRDNMAG
//