ID	4E5WA	STANDARD;	PRT;	302	AA.
DT	CONVERTED FROM PDB (SEQRES) 4E5W
DE	Tyrosine-protein kinase JAK1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	1.860
CC	R-Factor	0.184
FT	#SUB	185	1037 	VAL	A	251	1103 	ARG	B	Protein	B	3
FT	#SUB	186	1038 	LYS	A	244	1096 	HIS	B	Protein	B	2
FT	#SUB	186	1038 	LYS	A	251	1103 	ARG	B	Protein	B	2
FT	#SUB	188	1040 	ASP	A	244	1096 	HIS	B	Protein	S	8
FT	#SUB	188	1040 	ASP	A	247	1099 	MET	B	Protein	A	9
FT	#SUB	188	1040 	ASP	A	251	1103 	ARG	B	Protein	S	6
FT	#SUB	189	1041 	ARG	A	243	1095 	THR	B	Protein	S	11
FT	#SUB	189	1041 	ARG	A	244	1096 	HIS	B	Protein	A	3
FT	#SUB	189	1041 	ARG	A	245	1097 	GLY	B	Protein	S	1
FT	#SUB	189	1041 	ARG	A	246	1098 	GLN	B	Protein	B	4
FT	#SUB	191	1043 	SER	A	246	1098 	GLN	B	Protein	B	1
FT	#SUB	193	1045 	VAL	A	247	1099 	MET	B	Protein	S	1
FT	#SUB	201	1053 	LEU	A	247	1099 	MET	B	Protein	B	1
FT	#SUB	201	1053 	LEU	A	250	1102 	THR	B	Protein	B	3
FT	#SUB	202	1054 	MET	A	254	1106 	ASN	B	Protein	B	3
FT	#SUB	203	1055 	GLN	A	254	1106 	ASN	B	Protein	S	1
FT	#SUB	204	1056 	SER	A	251	1103 	ARG	B	Protein	S	5
FT	#SUB	243	1095 	THR	A	189	1041 	ARG	B	Protein	B	5
FT	#SUB	244	1096 	HIS	A	186	1038 	LYS	B	Protein	S	2
FT	#SUB	244	1096 	HIS	A	188	1040 	ASP	B	Protein	A	8
FT	#SUB	244	1096 	HIS	A	189	1041 	ARG	B	Protein	B	3
FT	#SUB	245	1097 	GLY	A	189	1041 	ARG	B	Protein	B	2
FT	#SUB	246	1098 	GLN	A	189	1041 	ARG	B	Protein	S	3
FT	#SUB	246	1098 	GLN	A	191	1043 	SER	B	Protein	S	1
FT	#SUB	246	1098 	GLN	A	249	1101 	VAL	B	Protein	B	1
FT	#SUB	247	1099 	MET	A	188	1040 	ASP	B	Protein	S	9
FT	#SUB	247	1099 	MET	A	193	1045 	VAL	B	Protein	S	1
FT	#SUB	247	1099 	MET	A	201	1053 	LEU	B	Protein	S	1
FT	#SUB	249	1101 	VAL	A	246	1098 	GLN	B	Protein	S	1
FT	#SUB	249	1101 	VAL	A	250	1102 	THR	B	Protein	S	1
FT	#SUB	250	1102 	THR	A	201	1053 	LEU	B	Protein	S	3
FT	#SUB	250	1102 	THR	A	249	1101 	VAL	B	Protein	S	1
FT	#SUB	250	1102 	THR	A	250	1102 	THR	B	Protein	S	1
FT	#SUB	251	1103 	ARG	A	185	1037 	VAL	B	Protein	S	3
FT	#SUB	251	1103 	ARG	A	186	1038 	LYS	B	Protein	S	2
FT	#SUB	251	1103 	ARG	A	188	1040 	ASP	B	Protein	S	6
FT	#SUB	251	1103 	ARG	A	204	1056 	SER	B	Protein	S	5
FT	#SUB	254	1106 	ASN	A	202	1054 	MET	B	Protein	S	3
FT	#SUB	254	1106 	ASN	A	203	1055 	GLN	B	Protein	S	1
FT	#SUB	257	1109 	LYS	A	257	1109 	LYS	B	Protein	S	1
FT	#HET	29	 881 	LEU	A	1	1201 	0NT	A	A	7
FT	#HET	30	 882 	GLY	A	1	1201 	0NT	A	B	4
FT	#HET	31	 883 	GLU	A	1	1201 	0NT	A	B	10
FT	#HET	32	 884 	GLY	A	1	1201 	0NT	A	B	4
FT	#HET	37	 889 	VAL	A	1	1201 	0NT	A	S	4
FT	#HET	54	 906 	ALA	A	1	1201 	0NT	A	S	4
FT	#HET	86	 938 	VAL	A	1	1201 	0NT	A	S	2
FT	#HET	104	 956 	MET	A	1	1201 	0NT	A	S	3
FT	#HET	105	 957 	GLU	A	1	1201 	0NT	A	B	5
FT	#HET	106	 958 	PHE	A	1	1201 	0NT	A	A	7
FT	#HET	107	 959 	LEU	A	1	1201 	0NT	A	B	6
FT	#HET	110	 962 	GLY	A	1	1201 	0NT	A	B	1
FT	#HET	151	1003 	ASP	A	1	1201 	0NT	A	S	3
FT	#HET	155	1007 	ARG	A	1	1201 	0NT	A	A	8
FT	#HET	156	1008 	ASN	A	1	1201 	0NT	A	S	9
FT	#HET	158	1010 	LEU	A	1	1201 	0NT	A	S	13
FT	#HET	168	1020 	GLY	A	1	1201 	0NT	A	B	1
FT	#HET	169	1021 	ASP	A	1	1201 	0NT	A	S	3
FT	#HET	245	1097 	GLY	A	2	1201 	PEG	B	B	4
FT	#HET	246	1098 	GLN	A	2	1201 	PEG	B	A	4
FT	DISORDER	60	64
FT	DISORDER	95	97
CC	SEQUENCE	294 AA (ATOM);
CC	GDIVSEKKPA TEVDPTHFEK RFLKRIRDLG EGHFGKVELC RYDPEGDNTG EQVAVKSLKN
CC	HIADLKKEIE ILRNLYHENI VKYKGICTEN GIKLIMEFLP SGSLKEYLPK NKNKINLKQQ
CC	LKYAVQICKG MDYLGSRQYV HRDLAARNVL VESEHQVKIG DFGLTKAIET DKEYYTVKDD
CC	RDSPVFWYAP ECLMQSKFYI ASDVWSFGVT LHELLTYCDS DSSPMALFLK MIGPTHGQMT
CC	VTRLVNTLKE GKRLPCPPNC PDEVYQLMRK CWEFQPSNRT SFQNLIEGFE ALLK
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES GDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	ATOM   GDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	       **************************************************
CC	SEQRES EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGI
CC	ATOM   EQVAVKSLK-----NHIADLKKEIEILRNLYHENIVKYKGICTE---NGI
CC	       *********     ******************************   ***
CC	SEQRES KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	ATOM   KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	       **************************************************
CC	SEQRES DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	ATOM   DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	       **************************************************
CC	SEQRES LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	ATOM   LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	       **************************************************
CC	SEQRES RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	ATOM   RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	       **************************************************
CC	SEQRES LK
CC	ATOM   LK
CC	       **
SQ	SEQUENCE	302 AA;      MW;         CN;
	GDIVSEKKPA TEVDPTHFEK RFLKRIRDLG EGHFGKVELC RYDPEGDNTG EQVAVKSLKP
	ESGGNHIADL KKEIEILRNL YHENIVKYKG ICTEDGGNGI KLIMEFLPSG SLKEYLPKNK
	NKINLKQQLK YAVQICKGMD YLGSRQYVHR DLAARNVLVE SEHQVKIGDF GLTKAIETDK
	EYYTVKDDRD SPVFWYAPEC LMQSKFYIAS DVWSFGVTLH ELLTYCDSDS SPMALFLKMI
	GPTHGQMTVT RLVNTLKEGK RLPCPPNCPD EVYQLMRKCW EFQPSNRTSF QNLIEGFEAL
	LK
//
ID	4E5WB	STANDARD;	PRT;	302	AA.
DT	CONVERTED FROM PDB (SEQRES) 4E5W
DE	Tyrosine-protein kinase JAK1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	1.860
CC	R-Factor	0.184
FT	#SUB	185	1037 	VAL	B	251	1103 	ARG	A	Protein	B	3
FT	#SUB	186	1038 	LYS	B	244	1096 	HIS	A	Protein	B	2
FT	#SUB	186	1038 	LYS	B	251	1103 	ARG	A	Protein	B	2
FT	#SUB	188	1040 	ASP	B	244	1096 	HIS	A	Protein	S	8
FT	#SUB	188	1040 	ASP	B	247	1099 	MET	A	Protein	A	9
FT	#SUB	188	1040 	ASP	B	251	1103 	ARG	A	Protein	S	6
FT	#SUB	189	1041 	ARG	B	243	1095 	THR	A	Protein	S	5
FT	#SUB	189	1041 	ARG	B	244	1096 	HIS	A	Protein	A	3
FT	#SUB	189	1041 	ARG	B	245	1097 	GLY	A	Protein	S	2
FT	#SUB	189	1041 	ARG	B	246	1098 	GLN	A	Protein	B	3
FT	#SUB	191	1043 	SER	B	246	1098 	GLN	A	Protein	B	1
FT	#SUB	193	1045 	VAL	B	247	1099 	MET	A	Protein	S	1
FT	#SUB	201	1053 	LEU	B	247	1099 	MET	A	Protein	B	1
FT	#SUB	201	1053 	LEU	B	250	1102 	THR	A	Protein	B	3
FT	#SUB	202	1054 	MET	B	254	1106 	ASN	A	Protein	B	3
FT	#SUB	203	1055 	GLN	B	254	1106 	ASN	A	Protein	S	1
FT	#SUB	204	1056 	SER	B	251	1103 	ARG	A	Protein	S	5
FT	#SUB	243	1095 	THR	B	189	1041 	ARG	A	Protein	A	11
FT	#SUB	244	1096 	HIS	B	186	1038 	LYS	A	Protein	S	2
FT	#SUB	244	1096 	HIS	B	188	1040 	ASP	A	Protein	A	8
FT	#SUB	244	1096 	HIS	B	189	1041 	ARG	A	Protein	B	3
FT	#SUB	245	1097 	GLY	B	189	1041 	ARG	A	Protein	B	1
FT	#SUB	246	1098 	GLN	B	189	1041 	ARG	A	Protein	S	4
FT	#SUB	246	1098 	GLN	B	191	1043 	SER	A	Protein	S	1
FT	#SUB	246	1098 	GLN	B	249	1101 	VAL	A	Protein	B	1
FT	#SUB	247	1099 	MET	B	188	1040 	ASP	A	Protein	S	9
FT	#SUB	247	1099 	MET	B	193	1045 	VAL	A	Protein	S	1
FT	#SUB	247	1099 	MET	B	201	1053 	LEU	A	Protein	S	1
FT	#SUB	249	1101 	VAL	B	246	1098 	GLN	A	Protein	S	1
FT	#SUB	249	1101 	VAL	B	250	1102 	THR	A	Protein	S	1
FT	#SUB	250	1102 	THR	B	201	1053 	LEU	A	Protein	S	3
FT	#SUB	250	1102 	THR	B	249	1101 	VAL	A	Protein	S	1
FT	#SUB	250	1102 	THR	B	250	1102 	THR	A	Protein	S	1
FT	#SUB	251	1103 	ARG	B	185	1037 	VAL	A	Protein	S	3
FT	#SUB	251	1103 	ARG	B	186	1038 	LYS	A	Protein	S	2
FT	#SUB	251	1103 	ARG	B	188	1040 	ASP	A	Protein	S	6
FT	#SUB	251	1103 	ARG	B	204	1056 	SER	A	Protein	S	5
FT	#SUB	254	1106 	ASN	B	202	1054 	MET	A	Protein	S	3
FT	#SUB	254	1106 	ASN	B	203	1055 	GLN	A	Protein	S	1
FT	#SUB	257	1109 	LYS	B	257	1109 	LYS	A	Protein	S	1
FT	#HET	29	 881 	LEU	B	3	1202 	0NT	B	A	6
FT	#HET	30	 882 	GLY	B	3	1202 	0NT	B	B	3
FT	#HET	31	 883 	GLU	B	3	1202 	0NT	B	B	11
FT	#HET	32	 884 	GLY	B	3	1202 	0NT	B	B	3
FT	#HET	37	 889 	VAL	B	3	1202 	0NT	B	S	4
FT	#HET	54	 906 	ALA	B	3	1202 	0NT	B	S	4
FT	#HET	86	 938 	VAL	B	3	1202 	0NT	B	S	3
FT	#HET	104	 956 	MET	B	3	1202 	0NT	B	S	2
FT	#HET	105	 957 	GLU	B	3	1202 	0NT	B	B	5
FT	#HET	106	 958 	PHE	B	3	1202 	0NT	B	A	7
FT	#HET	107	 959 	LEU	B	3	1202 	0NT	B	A	7
FT	#HET	110	 962 	GLY	B	3	1202 	0NT	B	B	1
FT	#HET	151	1003 	ASP	B	3	1202 	0NT	B	S	1
FT	#HET	155	1007 	ARG	B	3	1202 	0NT	B	A	8
FT	#HET	156	1008 	ASN	B	3	1202 	0NT	B	S	8
FT	#HET	158	1010 	LEU	B	3	1202 	0NT	B	S	12
FT	#HET	168	1020 	GLY	B	3	1202 	0NT	B	B	1
FT	#HET	169	1021 	ASP	B	3	1202 	0NT	B	S	3
FT	#HET	245	1097 	GLY	B	2	1201 	PEG	B	B	6
FT	#HET	246	1098 	GLN	B	2	1201 	PEG	B	A	4
FT	DISORDER	1	12
FT	DISORDER	61	64
FT	DISORDER	95	97
FT	DISORDER	178	179
FT	DISORDER	302	302
CC	SEQUENCE	280 AA (ATOM);
CC	VDPTHFEKRF LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ VAVKSLKPNH IADLKKEIEI
CC	LRNLYHENIV KYKGICTENG IKLIMEFLPS GSLKEYLPKN KNKINLKQQL KYAVQICKGM
CC	DYLGSRQYVH RDLAARNVLV ESEHQVKIGD FGLTKAIEKE YYTVKDDRDS PVFWYAPECL
CC	MQSKFYIASD VWSFGVTLHE LLTYCDSDSS PMALFLKMIG PTHGQMTVTR LVNTLKEGKR
CC	LPCPPNCPDE VYQLMRKCWE FQPSNRTSFQ NLIEGFEALL
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES GDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	ATOM   ------------VDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	                   **************************************
CC	SEQRES EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGI
CC	ATOM   EQVAVKSLKP----NHIADLKKEIEILRNLYHENIVKYKGICTE---NGI
CC	       **********    ******************************   ***
CC	SEQRES KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	ATOM   KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	       **************************************************
CC	SEQRES DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	ATOM   DLAARNVLVESEHQVKIGDFGLTKAIE--KEYYTVKDDRDSPVFWYAPEC
CC	       ***************************  *********************
CC	SEQRES LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	ATOM   LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	       **************************************************
CC	SEQRES RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	ATOM   RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	       **************************************************
CC	SEQRES LK
CC	ATOM   L-
CC	       * 
SQ	SEQUENCE	302 AA;      MW;         CN;
	GDIVSEKKPA TEVDPTHFEK RFLKRIRDLG EGHFGKVELC RYDPEGDNTG EQVAVKSLKP
	ESGGNHIADL KKEIEILRNL YHENIVKYKG ICTEDGGNGI KLIMEFLPSG SLKEYLPKNK
	NKINLKQQLK YAVQICKGMD YLGSRQYVHR DLAARNVLVE SEHQVKIGDF GLTKAIETDK
	EYYTVKDDRD SPVFWYAPEC LMQSKFYIAS DVWSFGVTLH ELLTYCDSDS SPMALFLKMI
	GPTHGQMTVT RLVNTLKEGK RLPCPPNCPD EVYQLMRKCW EFQPSNRTSF QNLIEGFEAL
	LK
//