ID	4E28A	STANDARD;	PRT;	325	AA.
DT	CONVERTED FROM PDB (SEQRES) 4E28
DE	Thymidylate synthase
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.300
CC	R-Factor	0.190
FT	#HET	62	  50 	ARG	A	1	401 	SO4	A	S	2
FT	#HET	89	  77 	LYS	A	3	403 	0MZ	A	S	13
FT	#HET	89	  77 	LYS	A	4	404 	9MZ	A	S	12
FT	#HET	90	  78 	ARG	A	3	403 	0MZ	A	B	5
FT	#HET	90	  78 	ARG	A	4	404 	9MZ	A	B	3
FT	#HET	91	  79 	VAL	A	3	403 	0MZ	A	B	9
FT	#HET	91	  79 	VAL	A	4	404 	9MZ	A	A	22
FT	#HET	92	  80 	PHE	A	3	403 	0MZ	A	A	13
FT	#HET	92	  80 	PHE	A	4	404 	9MZ	A	A	12
FT	#HET	99	  87 	GLU	A	3	403 	0MZ	A	S	3
FT	#HET	99	  87 	GLU	A	4	404 	9MZ	A	S	5
FT	#HET	113	 101 	LEU	A	3	403 	0MZ	A	B	1
FT	#HET	113	 101 	LEU	A	4	404 	9MZ	A	A	5
FT	#HET	116	 104 	LYS	A	3	403 	0MZ	A	S	9
FT	#HET	144	 132 	GLY	A	3	403 	0MZ	A	B	5
FT	#HET	144	 132 	GLY	A	4	404 	9MZ	A	B	1
FT	#HET	145	 133 	PRO	A	3	403 	0MZ	A	A	7
FT	#HET	145	 133 	PRO	A	4	404 	9MZ	A	S	2
FT	#HET	195	 183 	ASN	A	2	402 	SO4	A	S	1
FT	#HET	197	 185 	ARG	A	1	401 	SO4	A	S	8
FT	#HET	201	 189 	LEU	A	1	401 	SO4	A	S	1
FT	#HET	208	 196 	HIS	A	2	402 	SO4	A	S	2
FT	#HET	227	 215 	ARG	A	2	402 	SO4	A	S	11
FT	#HET	228	 216 	SER	A	2	402 	SO4	A	S	4
FT	#HET	232	 220 	GLY	A	3	403 	0MZ	A	B	2
FT	#HET	232	 220 	GLY	A	4	404 	9MZ	A	B	2
FT	#HET	233	 221 	LEU	A	3	403 	0MZ	A	A	11
FT	#HET	233	 221 	LEU	A	4	404 	9MZ	A	A	15
FT	#HET	234	 222 	GLY	A	4	404 	9MZ	A	B	2
FT	#HET	236	 224 	PRO	A	3	403 	0MZ	A	S	2
FT	#HET	236	 224 	PRO	A	4	404 	9MZ	A	A	9
FT	#HET	237	 225 	PHE	A	3	403 	0MZ	A	S	20
FT	#HET	237	 225 	PHE	A	4	404 	9MZ	A	A	28
FT	DISORDER	1	37
FT	DISORDER	117	141
FT	DISORDER	155	164
FT	DISORDER	324	325
CC	SEQUENCE	251 AA (ATOM);
CC	PPHGELQYLG QIQHILRCGV RKDDRTGTGT LSVFGMQARY SLRDEFPLLT TKRVFWKGVL
CC	EELLWFIKGS TNAKELSSKD LGPVYGFQWR HFYSGQGVDQ LQRVIDTIKT NPDDRRIIMX
CC	AWNPRDLPLM ALPPXHALCQ FYVVNSELSC QLYQRSGDMG LGVPFNIASY ALLTYMIAHI
CC	TGLKPGDFIH TLGDAHIYLN HIEPLKIQLQ REPRPFPKLR ILRKVEKIDD FKAEDFQIEG
CC	YNPHPTIKME M
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MRGSHHHHHHGSMPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQ
CC	ATOM   -------------------------------------PPHGELQYLGQIQ
CC	                                            *************
CC	SEQRES HILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEEL
CC	ATOM   HILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEEL
CC	       **************************************************
CC	SEQRES LWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQ
CC	ATOM   LWFIKGSTNAKELSSK-------------------------DLGPVYGFQ
CC	       ****************                         *********
CC	SEQRES WRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMXAWNPRDLP
CC	ATOM   WRHF----------YSGQGVDQLQRVIDTIKTNPDDRRIIMXAWNPRDLP
CC	       ****          ************************************
CC	SEQRES LMALPPXHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIA
CC	ATOM   LMALPPXHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIA
CC	       **************************************************
CC	SEQRES HITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKI
CC	ATOM   HITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKI
CC	       **************************************************
CC	SEQRES DDFKAEDFQIEGYNPHPTIKMEMAV
CC	ATOM   DDFKAEDFQIEGYNPHPTIKMEM--
CC	       ***********************  
SQ	SEQUENCE	325 AA;      MW;         CN;
	MRGSHHHHHH GSMPVAGSEL PRRPLPPAAQ ERDAEPRPPH GELQYLGQIQ HILRCGVRKD
	DRTGTGTLSV FGMQARYSLR DEFPLLTTKR VFWKGVLEEL LWFIKGSTNA KELSSKGVKI
	WDANGSRDFL DSLGFSTREE GDLGPVYGFQ WRHFGAEYRD MESDYSGQGV DQLQRVIDTI
	KTNPDDRRII MXAWNPRDLP LMALPPXHAL CQFYVVNSEL SCQLYQRSGD MGLGVPFNIA
	SYALLTYMIA HITGLKPGDF IHTLGDAHIY LNHIEPLKIQ LQREPRPFPK LRILRKVEKI
	DDFKAEDFQI EGYNPHPTIK MEMAV
//