ID 4DK5A STANDARD; PRT; 959 AA. DT CONVERTED FROM PDB (SEQRES) 4DK5 DE Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isof DE orm OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.950 CC R-Factor 0.224 FT #HET 62 205 LYS A 1 1201 SO4 A B 1 FT #HET 63 206 PRO A 1 1201 SO4 A B 3 FT #HET 64 207 LEU A 1 1201 SO4 A A 9 FT #HET 69 212 TRP A 1 1201 SO4 A S 8 FT #HET 145 288 LYS A 1 1201 SO4 A S 2 FT #HET 433 576 TRP A 2 1202 SO4 A S 6 FT #HET 436 579 ARG A 2 1202 SO4 A S 6 FT #HET 460 603 ILE A 2 1202 SO4 A S 1 FT #HET 463 606 LYS A 2 1202 SO4 A S 6 FT #HET 506 649 GLU A 3 1203 SO4 A B 1 FT #HET 507 650 SER A 3 1203 SO4 A B 3 FT #HET 508 651 LEU A 3 1203 SO4 A B 4 FT #HET 509 652 GLU A 3 1203 SO4 A B 1 FT #HET 541 684 ARG A 3 1203 SO4 A S 4 FT #HET 544 687 ARG A 3 1203 SO4 A S 1 FT #HET 659 802 LYS A 4 1204 0KO A S 3 FT #HET 661 804 MET A 4 1204 0KO A A 4 FT #HET 662 805 ALA A 4 1204 0KO A A 5 FT #HET 688 831 ILE A 4 1204 0KO A S 1 FT #HET 690 833 LYS A 4 1204 0KO A S 2 FT #HET 695 838 LEU A 4 1204 0KO A S 1 FT #HET 698 841 ASP A 4 1204 0KO A S 3 FT #HET 724 867 TYR A 4 1204 0KO A S 7 FT #HET 736 879 ILE A 4 1204 0KO A S 1 FT #HET 737 880 GLU A 4 1204 0KO A B 3 FT #HET 738 881 ILE A 4 1204 0KO A A 2 FT #HET 739 882 VAL A 4 1204 0KO A A 8 FT #HET 742 885 ALA A 4 1204 0KO A S 1 FT #HET 744 887 THR A 4 1204 0KO A S 1 FT #HET 747 890 LYS A 4 1204 0KO A S 4 FT #HET 810 953 MET A 4 1204 0KO A S 9 FT #HET 820 963 ILE A 4 1204 0KO A S 6 FT #HET 821 964 ASP A 4 1204 0KO A A 14 FT DISORDER 108 125 FT DISORDER 179 208 FT DISORDER 231 234 FT DISORDER 294 313 FT DISORDER 346 352 FT DISORDER 380 382 FT DISORDER 390 403 FT DISORDER 612 614 FT DISORDER 825 836 FT DISORDER 946 959 CC SEQUENCE 834 AA (ATOM); CC SEESQAFQRQ LTALIGYDVT DVSNVHDDEL EFTRRGLVTP RMAEVASRDP KLYAMHPWVT CC SKPLPEYLWK KIANNCIFIV IHRSTTSQTI KVSPDDTPGA ILQSFFTDFV LRVCGRDEYL CC VGETPIKNFQ WVRHCLKNGE EIHVVLDTPP DPALDEVRKE VSLWDCDRKF RVKIRGIDIP CC VLDLTVFVEA NIQHGQQVLC QRRTSPKPFT EEVLWNVWLE FSIKIKDLPK GALLNLQIYC CC GKVQLLYYVN LLLIDHRFLL RRGEYVLHMW QISSFNADKL TSATNPDKEN SMSISILLDN CC PIALPKHMPN QLRKQLEAII ATDPLNPLTA EDKELLWHFR YESLKHPKAY PKLFSSVKWG CC QQEIVAKTYQ LLARREVWDQ SALDVGLTMQ LLDCNFSDEN VRAIAVQKLE SLEDDDVLHY CC LLQLVQAVKF EPYHDSALAR FLLKRGLRNK RIGHFLFWFL RSEIAQSRHY QQRFAVILEA CC YLRGCGTAML HDFTQQVQVI EMLQKVTLDI KSLSADVSSQ VISQLKQKLE NLQNSQLPES CC FRVPYDPGLK AGALAIEKCK VMASKKKPLW LEFKCADPTA LSNETIGIIF KHGDDLRQDM CC LILQILRIME SIWETESLDL CLLPYGCIST GDKIGMIEIV KDATTIAKIQ QSTVGNTGAF CC KDEVLNHWLK EKSPTEEKFQ AAVERFVYSC AGYCVATFVL GIGDRHNDNI MITETGNLFH CC IDFGHKERVP FVLTPDFLFV MGTSGKKTSP HFQKFQDICV KAYLALRHHT NLLIILFSMM CC LMTGMPQLTS KEDIEYIRDA LTVGKNEEDA KKYFLDQIEV CRDKGWTVQF NWFL CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES SEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDP CC ATOM SEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDP CC ************************************************** CC SEQRES KLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGA CC ATOM KLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGA CC ************************************************** CC SEQRES ILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWV CC ATOM ILQSFFT------------------DFVLRVCGRDEYLVGETPIKNFQWV CC ******* ************************* CC SEQRES RHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHG CC ATOM RHCLKNGEEIHVVLDTPPDPALDEVRKE---------------------- CC **************************** CC SEQRES KDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQV CC ATOM --------VSLWDCDRKFRVKIRGIDIPVL----DLTVFVEANIQHGQQV CC ********************** **************** CC SEQRES LCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSS CC ATOM LCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCG------- CC ******************************************* CC SEQRES KASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGED CC ATOM -------------KVQLLYYVNLLLIDHRFLLRRGEYVLHMWQIS----- CC ******************************** CC SEQRES QGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRV CC ATOM --SFNADKLTSATNPDKENSMSISILLDN---PIALPKH----------- CC *************************** ******* CC SEQRES RAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLF CC ATOM ---MPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLF CC *********************************************** CC SEQRES SSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAI CC ATOM SSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAI CC ************************************************** CC SEQRES AVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGH CC ATOM AVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGH CC ************************************************** CC SEQRES FLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQ CC ATOM FLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQ CC ************************************************** CC SEQRES KVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKA CC ATOM KVTLDIKSLSA---DVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKA CC *********** ************************************ CC SEQRES GALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDML CC ATOM GALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDML CC ************************************************** CC SEQRES ILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQ CC ATOM ILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQ CC ************************************************** CC SEQRES STVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLG CC ATOM STVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLG CC ************************************************** CC SEQRES IGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLF CC ATOM IGDRHNDNIMITETGNLFHIDFGH------------KERVPFVLTPDFLF CC ************************ ************** CC SEQRES VMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLT CC ATOM VMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLT CC ************************************************** CC SEQRES SKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLG CC ATOM SKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFL----- CC ********************************************* CC SEQRES IKQGEKHSA CC ATOM --------- CC SQ SEQUENCE 959 AA; MW; CN; SEESQAFQRQ LTALIGYDVT DVSNVHDDEL EFTRRGLVTP RMAEVASRDP KLYAMHPWVT SKPLPEYLWK KIANNCIFIV IHRSTTSQTI KVSPDDTPGA ILQSFFTKMA KKKSLMDIPE SQSEQDFVLR VCGRDEYLVG ETPIKNFQWV RHCLKNGEEI HVVLDTPPDP ALDEVRKEEW PLVDDCTGVT GYHEQLTIHG KDHESVFTVS LWDCDRKFRV KIRGIDIPVL PRNTDLTVFV EANIQHGQQV LCQRRTSPKP FTEEVLWNVW LEFSIKIKDL PKGALLNLQI YCGKAPALSS KASAESPSSE SKGKVQLLYY VNLLLIDHRF LLRRGEYVLH MWQISGKGED QGSFNADKLT SATNPDKENS MSISILLDNY CHPIALPKHQ PTPDPEGDRV RAEMPNQLRK QLEAIIATDP LNPLTAEDKE LLWHFRYESL KHPKAYPKLF SSVKWGQQEI VAKTYQLLAR REVWDQSALD VGLTMQLLDC NFSDENVRAI AVQKLESLED DDVLHYLLQL VQAVKFEPYH DSALARFLLK RGLRNKRIGH FLFWFLRSEI AQSRHYQQRF AVILEAYLRG CGTAMLHDFT QQVQVIEMLQ KVTLDIKSLS AEKYDVSSQV ISQLKQKLEN LQNSQLPESF RVPYDPGLKA GALAIEKCKV MASKKKPLWL EFKCADPTAL SNETIGIIFK HGDDLRQDML ILQILRIMES IWETESLDLC LLPYGCISTG DKIGMIEIVK DATTIAKIQQ STVGNTGAFK DEVLNHWLKE KSPTEEKFQA AVERFVYSCA GYCVATFVLG IGDRHNDNIM ITETGNLFHI DFGHILGNYK SFLGINKERV PFVLTPDFLF VMGTSGKKTS PHFQKFQDIC VKAYLALRHH TNLLIILFSM MLMTGMPQLT SKEDIEYIRD ALTVGKNEED AKKYFLDQIE VCRDKGWTVQ FNWFLHLVLG IKQGEKHSA //