ID	4DH6A	STANDARD;	PRT;	411	AA.
DT	CONVERTED FROM PDB (SEQRES) 4DH6
DE	Beta-secretase 1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.500
CC	R-Factor	0.231
FT	#HET	28	   9 	LYS	A	9	409 	GOL	A	B	1
FT	#HET	30	  11 	GLY	A	9	409 	GOL	A	B	4
FT	#HET	31	  12 	GLN	A	9	409 	GOL	A	B	2
FT	#HET	32	  13 	GLY	A	9	409 	GOL	A	B	10
FT	#HET	33	  14 	TYR	A	9	409 	GOL	A	S	3
FT	#HET	49	  30 	LEU	A	11	411 	0KN	A	S	3
FT	#HET	51	  32 	ASP	A	11	411 	0KN	A	S	10
FT	#HET	53	  34 	GLY	A	11	411 	0KN	A	B	9
FT	#HET	54	  35 	SER	A	11	411 	0KN	A	S	2
FT	#HET	64	  45 	HIS	A	1	401 	IOD	A	S	1
FT	#HET	69	  50 	ARG	A	10	410 	GOL	A	A	5
FT	#HET	70	  51 	TYR	A	10	410 	GOL	A	A	7
FT	#HET	87	  68 	TYR	A	6	406 	IOD	A	B	2
FT	#HET	87	  68 	TYR	A	7	407 	IOD	A	S	4
FT	#HET	88	  69 	VAL	A	11	411 	0KN	A	S	1
FT	#HET	89	  70 	PRO	A	7	407 	IOD	A	S	1
FT	#HET	89	  70 	PRO	A	11	411 	0KN	A	B	3
FT	#HET	90	  71 	TYR	A	11	411 	0KN	A	A	10
FT	#HET	91	  72 	THR	A	11	411 	0KN	A	A	13
FT	#HET	123	 104 	GLU	A	1	401 	IOD	A	B	3
FT	#HET	124	 105 	SER	A	1	401 	IOD	A	A	2
FT	#HET	126	 107 	LYS	A	2	402 	IOD	A	B	1
FT	#HET	127	 108 	PHE	A	11	411 	0KN	A	A	4
FT	#HET	129	 110 	ILE	A	11	411 	0KN	A	S	1
FT	#HET	134	 115 	TRP	A	11	411 	0KN	A	S	4
FT	#HET	137	 118 	ILE	A	11	411 	0KN	A	S	2
FT	#HET	145	 126 	ILE	A	11	411 	0KN	A	A	3
FT	#HET	147	 128 	ARG	A	11	411 	0KN	A	S	1
FT	#HET	148	 129 	PRO	A	6	406 	IOD	A	A	2
FT	#HET	153	 134 	GLU	A	3	403 	IOD	A	S	1
FT	#HET	198	 179 	ILE	A	8	408 	IOD	A	S	1
FT	#HET	200	 181 	HIS	A	8	408 	IOD	A	S	2
FT	#HET	203	 184 	TYR	A	8	408 	IOD	A	S	3
FT	#HET	207	 188 	LEU	A	8	408 	IOD	A	S	1
FT	#HET	217	 198 	TYR	A	11	411 	0KN	A	S	6
FT	#HET	241	 222 	TYR	A	5	405 	IOD	A	S	2
FT	#HET	247	 228 	ASP	A	11	411 	0KN	A	S	6
FT	#HET	248	 229 	SER	A	9	409 	GOL	A	B	1
FT	#HET	249	 230 	GLY	A	11	411 	0KN	A	B	9
FT	#HET	250	 231 	THR	A	9	409 	GOL	A	B	1
FT	#HET	250	 231 	THR	A	11	411 	0KN	A	S	2
FT	#HET	251	 232 	THR	A	9	409 	GOL	A	A	6
FT	#HET	254	 235 	ARG	A	11	411 	0KN	A	S	1
FT	#HET	348	 329 	THR	A	11	411 	0KN	A	S	3
FT	#HET	351	 332 	VAL	A	11	411 	0KN	A	S	2
FT	#HET	354	 335 	ALA	A	9	409 	GOL	A	S	4
FT	#HET	358	 339 	GLU	A	9	409 	GOL	A	S	2
FT	#HET	368	 349 	ARG	A	4	404 	IOD	A	S	1
FT	#HET	370	 351 	ARG	A	4	404 	IOD	A	S	1
FT	DISORDER	1	17
FT	DISORDER	176	186
FT	DISORDER	292	293
FT	DISORDER	329	335
FT	DISORDER	405	411
CC	SEQUENCE	367 AA (ATOM);
CC	FVEMVDNLRG KSGQGYYVEM TVGSPPQTLN ILVDTGSSNF AVGAAPHPFL HRYYQRQLSS
CC	TYRDLRKGVY VPYTQGKWEG ELGTDLVSIP HGPNVTVRAN IAAITESDKF FINGSNWEGI
CC	LGLAYAEIAR PDDSLEPFFD SLVKQTHVPN LFSLQLCGAS VGGSMIIGGI DHSLYTGSLW
CC	YTPIRREWYY EVIIVRVEIN GQDLKMDCKE YNYDKSIVDS GTTNLRLPKK VFEAAVKSIK
CC	AASSTEKFPD GFWLGEQLVC WQATPWNIFP VISLYLMGEV TNQSFRITIL PQQYLRPVDD
CC	CYKFAISQSS TGTVMGAVIM EGFYVVFDRA RKRIGFAVSA CHVHDEFRTA AVEGPFVTLD
CC	MEDCGYN
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES LPRETDEEPEEPGKKGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILV
CC	ATOM   -----------------FVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILV
CC	                        *********************************
CC	SEQRES DTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELG
CC	ATOM   DTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELG
CC	       **************************************************
CC	SEQRES TDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDD
CC	ATOM   TDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDD
CC	       **************************************************
CC	SEQRES SLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDH
CC	ATOM   SLEPFFDSLVKQTHVPNLFSLQLCG-----------ASVGGSMIIGGIDH
CC	       *************************           **************
CC	SEQRES SLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGT
CC	ATOM   SLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGT
CC	       **************************************************
CC	SEQRES TNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFP
CC	ATOM   TNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQA--TPWNIFP
CC	       *****************************************  *******
CC	SEQRES VISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGT
CC	ATOM   VISLYLMGEVTNQSFRITILPQQYLRPV-------DDCYKFAISQSSTGT
CC	       ****************************       ***************
CC	SEQRES VMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMED
CC	ATOM   VMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMED
CC	       **************************************************
CC	SEQRES CGYNIPQTDES
CC	ATOM   CGYN-------
CC	       ****       
SQ	SEQUENCE	411 AA;      MW;         CN;
	LPRETDEEPE EPGKKGSFVE MVDNLRGKSG QGYYVEMTVG SPPQTLNILV DTGSSNFAVG
	AAPHPFLHRY YQRQLSSTYR DLRKGVYVPY TQGKWEGELG TDLVSIPHGP NVTVRANIAA
	ITESDKFFIN GSNWEGILGL AYAEIARPDD SLEPFFDSLV KQTHVPNLFS LQLCGAGFPL
	NQSEVLASVG GSMIIGGIDH SLYTGSLWYT PIRREWYYEV IIVRVEINGQ DLKMDCKEYN
	YDKSIVDSGT TNLRLPKKVF EAAVKSIKAA SSTEKFPDGF WLGEQLVCWQ AGTTPWNIFP
	VISLYLMGEV TNQSFRITIL PQQYLRPVED VATSQDDCYK FAISQSSTGT VMGAVIMEGF
	YVVFDRARKR IGFAVSACHV HDEFRTAAVE GPFVTLDMED CGYNIPQTDE S
//