ID	4D85A	STANDARD;	PRT;	408	AA.
DT	CONVERTED FROM PDB (SEQRES) 4D85
DE	Beta-secretase 1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.650
CC	R-Factor	0.209
FT	#HET	27	  13 	GLY	A	1	401 	0GU	A	B	2
FT	#HET	28	  14 	GLN	A	1	401 	0GU	A	B	6
FT	#HET	29	  15 	GLY	A	1	401 	0GU	A	B	3
FT	#HET	46	  32 	LEU	A	1	401 	0GU	A	S	1
FT	#HET	48	  34 	ASP	A	1	401 	0GU	A	S	7
FT	#HET	50	  36 	GLY	A	1	401 	0GU	A	B	8
FT	#HET	51	  37 	SER	A	1	401 	0GU	A	A	4
FT	#HET	85	  71 	VAL	A	1	401 	0GU	A	S	1
FT	#HET	86	  72 	PRO	A	1	401 	0GU	A	B	2
FT	#HET	87	  73 	TYR	A	1	401 	0GU	A	S	10
FT	#HET	88	  74 	THR	A	1	401 	0GU	A	A	8
FT	#HET	89	  75 	GLN	A	1	401 	0GU	A	A	10
FT	#HET	90	  76 	GLY	A	1	401 	0GU	A	B	3
FT	#HET	119	 105 	THR	A	2	402 	IOD	A	B	2
FT	#HET	120	 106 	GLU	A	2	402 	IOD	A	B	1
FT	#HET	121	 107 	SER	A	2	402 	IOD	A	S	1
FT	#HET	123	 109 	LYS	A	1	401 	0GU	A	B	1
FT	#HET	124	 110 	PHE	A	1	401 	0GU	A	A	7
FT	#HET	126	 112 	ILE	A	1	401 	0GU	A	S	3
FT	#HET	131	 117 	TRP	A	1	401 	0GU	A	S	1
FT	#HET	142	 128 	ILE	A	1	401 	0GU	A	A	2
FT	#HET	144	 130 	ARG	A	1	401 	0GU	A	S	5
FT	#HET	214	 190 	TYR	A	1	401 	0GU	A	S	7
FT	#HET	244	 220 	ASP	A	1	401 	0GU	A	S	7
FT	#HET	246	 222 	GLY	A	1	401 	0GU	A	B	7
FT	#HET	247	 223 	THR	A	1	401 	0GU	A	A	7
FT	#HET	248	 224 	THR	A	1	401 	0GU	A	A	3
FT	#HET	251	 227 	ARG	A	1	401 	0GU	A	S	1
FT	DISORDER	1	12
FT	DISORDER	174	183
FT	DISORDER	328	332
FT	DISORDER	402	408
CC	SEQUENCE	374 AA (ATOM);
CC	GSFVEMVDNL RGKSGQGYYV EMTVGSPPQT LNILVDTGSS NFAVGAAPHP FLHRYYQRQL
CC	SSTYRDLRKG VYVPYTQGKW EGELGTDLVS IPHGPNVTVR ANIAAITESD KFFINGSNWE
CC	GILGLAYAEI ARPDDSLEPF FDSLVKQTHV PNLFSLQLCG AASVGGSMII GGIDHSLYTG
CC	SLWYTPIRRE WYYEVIIVRV EINGQDLKMD CKEYNYDKSI VDSGTTNLRL PKKVFEAAVK
CC	SIKAASSTEK FPDGFWLGEQ LVCWQAGTTP WNIFPVISLY LMGEVTNQSF RITILPQQYL
CC	RPVEDDDCYK FAISQSSTGT VMGAVIMEGF YVVFDRARKR IGFAVSACHV HDEFRTAAVE
CC	GPFVTLDMED CGYN
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES GPDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTG
CC	ATOM   ------------GSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTG
CC	                   **************************************
CC	SEQRES SSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDL
CC	ATOM   SSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDL
CC	       **************************************************
CC	SEQRES VSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLE
CC	ATOM   VSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLE
CC	       **************************************************
CC	SEQRES PFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLY
CC	ATOM   PFFDSLVKQTHVPNLFSLQLCGA----------ASVGGSMIIGGIDHSLY
CC	       ***********************          *****************
CC	SEQRES TGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNL
CC	ATOM   TGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNL
CC	       **************************************************
CC	SEQRES RLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVIS
CC	ATOM   RLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVIS
CC	       **************************************************
CC	SEQRES LYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMG
CC	ATOM   LYLMGEVTNQSFRITILPQQYLRPVED-----DDCYKFAISQSSTGTVMG
CC	       ***************************     ******************
CC	SEQRES AVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGY
CC	ATOM   AVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGY
CC	       **************************************************
CC	SEQRES NIPQTDES
CC	ATOM   N-------
CC	       *       
SQ	SEQUENCE	408 AA;      MW;         CN;
	GPDEEPEEPG RRGSFVEMVD NLRGKSGQGY YVEMTVGSPP QTLNILVDTG SSNFAVGAAP
	HPFLHRYYQR QLSSTYRDLR KGVYVPYTQG KWEGELGTDL VSIPHGPNVT VRANIAAITE
	SDKFFINGSN WEGILGLAYA EIARPDDSLE PFFDSLVKQT HVPNLFSLQL CGAGFPLNQS
	EVLASVGGSM IIGGIDHSLY TGSLWYTPIR REWYYEVIIV RVEINGQDLK MDCKEYNYDK
	SIVDSGTTNL RLPKKVFEAA VKSIKAASST EKFPDGFWLG EQLVCWQAGT TPWNIFPVIS
	LYLMGEVTNQ SFRITILPQQ YLRPVEDVAT SQDDCYKFAI SQSSTGTVMG AVIMEGFYVV
	FDRARKRIGF AVSACHVHDE FRTAAVEGPF VTLDMEDCGY NIPQTDES
//