ID	4D78A	STANDARD;	PRT;	487	AA.
DT	CONVERTED FROM PDB (SEQRES) 4D78
DE	CYTOCHROME P450 3A4
OS	HOMO SAPIENS
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.800
CC	R-Factor	0.197
FT	#HET	35	  55 	LYS	A	4	1602 	GOL	A	B	2
FT	#HET	36	  56 	GLY	A	4	1602 	GOL	A	B	9
FT	#HET	37	  57 	PHE	A	4	1602 	GOL	A	A	6
FT	#HET	38	  58 	CYS	A	4	1602 	GOL	A	A	9
FT	#HET	39	  59 	MET	A	4	1602 	GOL	A	A	6
FT	#HET	85	 105 	ARG	A	1	1500 	HEM	A	S	11
FT	#HET	85	 105 	ARG	A	2	1600 	J9K	A	S	2
FT	#HET	88	 108 	PHE	A	2	1600 	J9K	A	S	2
FT	#HET	98	 118 	ILE	A	1	1500 	HEM	A	S	3
FT	#HET	99	 119 	SER	A	1	1500 	HEM	A	S	1
FT	#HET	99	 119 	SER	A	2	1600 	J9K	A	S	1
FT	#HET	100	 120 	ILE	A	2	1600 	J9K	A	S	1
FT	#HET	106	 126 	TRP	A	1	1500 	HEM	A	S	5
FT	#HET	110	 130 	ARG	A	1	1500 	HEM	A	S	5
FT	#HET	117	 137 	PHE	A	1	1500 	HEM	A	S	2
FT	#HET	191	 211 	LEU	A	2	1600 	J9K	A	S	2
FT	#HET	281	 301 	ILE	A	2	1600 	J9K	A	S	2
FT	#HET	282	 302 	PHE	A	1	1500 	HEM	A	S	2
FT	#HET	284	 304 	PHE	A	2	1600 	J9K	A	S	8
FT	#HET	285	 305 	ALA	A	1	1500 	HEM	A	S	5
FT	#HET	285	 305 	ALA	A	2	1600 	J9K	A	A	3
FT	#HET	286	 306 	GLY	A	1	1500 	HEM	A	B	2
FT	#HET	289	 309 	THR	A	1	1500 	HEM	A	S	6
FT	#HET	289	 309 	THR	A	2	1600 	J9K	A	S	3
FT	#HET	293	 313 	VAL	A	1	1500 	HEM	A	S	1
FT	#HET	349	 369 	ILE	A	1	1500 	HEM	A	S	1
FT	#HET	349	 369 	ILE	A	2	1600 	J9K	A	A	4
FT	#HET	350	 370 	ALA	A	1	1500 	HEM	A	S	1
FT	#HET	353	 373 	LEU	A	1	1500 	HEM	A	S	5
FT	#HET	355	 375 	ARG	A	1	1500 	HEM	A	S	9
FT	#HET	405	 425 	ASP	A	3	1601 	GOL	A	B	5
FT	#HET	406	 426 	ASN	A	3	1601 	GOL	A	B	3
FT	#HET	407	 427 	ILE	A	3	1601 	GOL	A	B	5
FT	#HET	408	 428 	ASP	A	3	1601 	GOL	A	A	6
FT	#HET	409	 429 	PRO	A	3	1601 	GOL	A	S	3
FT	#HET	414	 434 	PRO	A	1	1500 	HEM	A	B	3
FT	#HET	415	 435 	PHE	A	1	1500 	HEM	A	A	14
FT	#HET	416	 436 	GLY	A	1	1500 	HEM	A	B	5
FT	#HET	417	 437 	SER	A	1	1500 	HEM	A	B	2
FT	#HET	420	 440 	ARG	A	1	1500 	HEM	A	A	11
FT	#HET	421	 441 	ASN	A	1	1500 	HEM	A	B	7
FT	#HET	422	 442 	CYS	A	1	1500 	HEM	A	A	28
FT	#HET	423	 443 	ILE	A	1	1500 	HEM	A	S	3
FT	#HET	424	 444 	GLY	A	1	1500 	HEM	A	B	7
FT	#HET	427	 447 	PHE	A	1	1500 	HEM	A	S	1
FT	#HET	428	 448 	ALA	A	1	1500 	HEM	A	S	2
FT	#HET	432	 452 	MET	A	1	1500 	HEM	A	S	1
FT	#HET	458	 478 	SER	A	4	1602 	GOL	A	B	3
FT	#HET	459	 479 	LEU	A	4	1602 	GOL	A	B	3
FT	#HET	460	 480 	GLY	A	4	1602 	GOL	A	B	3
FT	#HET	462	 482 	LEU	A	2	1600 	J9K	A	S	1
FT	DISORDER	1	6
FT	DISORDER	245	246
FT	DISORDER	260	268
FT	DISORDER	478	487
CC	Miss-BB	1
CC	Miss-SC	1
CC	SEQUENCE	460 AA (ATOM);
CC	THSHGLFKKL GIPGPTPLPF LGNILSYHKG FCMFDMECHK KYGKVWGFYD GQQPVLAITD
CC	PDMIKTVLVK ECYSVFTNRR PFGPVGFMKS AISIAEDEEW KRLRSLLSPT FTSGKLKEMV
CC	PIIAQYGDVL VRNLRREAET GKPVTLKDVF GAYSMDVITS TSFGVNIDSL NNPQDPFVEN
CC	TKKLLRFDFL DPFFLSITVF PFLIPILEVL NICVFPREVT NFLRKSVKRM KESRLEDTHR
CC	VDFLQLMIDS QALSDLELVA QSIIFIFAGY ETTSSVLSFI MYELATHPDV QQKLQEEIDA
CC	VLPNKAPPTY DTVLQMEYLD MVVNETLRLF PIAMRLERVC KKDVEINGMF IPKGVVVMIP
CC	SYALHRDPKY WTEPEKFLPE RFSKKNKDNI DPYIYTPFGS GPRNCIGMRF ALMNMKLALI
CC	RVLQNFSFKP CKETQIPLKL SLGGLLQPEK PVVLKVESRD
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MAYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGK
CC	ATOM   ------THSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGK
CC	             ********************************************
CC	SEQRES VWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
CC	ATOM   VWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
CC	       **************************************************
CC	SEQRES AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPV
CC	ATOM   AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPV
CC	       **************************************************
CC	SEQRES TLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFF
CC	ATOM   TLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFF
CC	       **************************************************
CC	SEQRES LSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVD
CC	ATOM   LSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDT--HRVD
CC	       ********************************************  ****
CC	SEQRES FLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYE
CC	ATOM   FLQLMIDSQ---------ALSDLELVAQSIIFIFAGYETTSSVLSFIMYE
CC	       *********         ********************************
CC	SEQRES LATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA
CC	ATOM   LATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA
CC	       **************************************************
CC	SEQRES MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
CC	ATOM   MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
CC	       **************************************************
CC	SEQRES KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKE
CC	ATOM   KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKE
CC	       **************************************************
CC	SEQRES TQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGAHHHH
CC	ATOM   TQIPLKLSLGGLLQPEKPVVLKVESRD----------
CC	       ***************************          
SQ	SEQUENCE	487 AA;      MW;         CN;
	MAYLYGTHSH GLFKKLGIPG PTPLPFLGNI LSYHKGFCMF DMECHKKYGK VWGFYDGQQP
	VLAITDPDMI KTVLVKECYS VFTNRRPFGP VGFMKSAISI AEDEEWKRLR SLLSPTFTSG
	KLKEMVPIIA QYGDVLVRNL RREAETGKPV TLKDVFGAYS MDVITSTSFG VNIDSLNNPQ
	DPFVENTKKL LRFDFLDPFF LSITVFPFLI PILEVLNICV FPREVTNFLR KSVKRMKESR
	LEDTQKHRVD FLQLMIDSQN SKETESHKAL SDLELVAQSI IFIFAGYETT SSVLSFIMYE
	LATHPDVQQK LQEEIDAVLP NKAPPTYDTV LQMEYLDMVV NETLRLFPIA MRLERVCKKD
	VEINGMFIPK GVVVMIPSYA LHRDPKYWTE PEKFLPERFS KKNKDNIDPY IYTPFGSGPR
	NCIGMRFALM NMKLALIRVL QNFSFKPCKE TQIPLKLSLG GLLQPEKPVV LKVESRDGTV
	SGAHHHH
//