ID	4BZ8A	STANDARD;	PRT;	446	AA.
DT	CONVERTED FROM PDB (SEQRES) 4BZ8
DE	HISTONE DEACETYLASE 8
OS	SCHISTOSOMA MANSONI
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.210
CC	R-Factor	0.180
FT	#SUB	10	  10 	GLN	A	218	 218 	GLY	B	Protein	S	3
FT	#SUB	10	  10 	GLN	A	219	 219 	THR	B	Protein	S	2
FT	#SUB	39	  39 	PRO	A	90	  90 	LEU	B	Protein	B	1
FT	#SUB	40	  40 	GLU	A	90	  90 	LEU	B	Protein	B	2
FT	#SUB	41	  41 	LEU	A	90	  90 	LEU	B	Protein	B	2
FT	#SUB	42	  42 	SER	A	90	  90 	LEU	B	Protein	B	1
FT	#SUB	42	  42 	SER	A	93	  93 	ASP	B	Protein	S	5
FT	#SUB	43	  43 	ARG	A	96	  96 	SER	B	Protein	S	2
FT	#SUB	43	  43 	ARG	A	147	 147 	GLU	B	Protein	S	3
FT	#SUB	44	  44 	VAL	A	99	  99 	TYR	B	Protein	S	1
FT	#SUB	45	  45 	PRO	A	99	  99 	TYR	B	Protein	S	3
FT	#SUB	48	  48 	GLN	A	214	 214 	GLY	B	Protein	A	4
FT	#SUB	48	  48 	GLN	A	216	 216 	PHE	B	Protein	S	7
FT	#SUB	48	  48 	GLN	A	217	 217 	PRO	B	Protein	S	3
FT	#SUB	49	  49 	TRP	A	214	 214 	GLY	B	Protein	A	6
FT	#SUB	49	  49 	TRP	A	215	 215 	PHE	B	Protein	B	2
FT	#SUB	50	  50 	ASP	A	215	 215 	PHE	B	Protein	B	4
FT	#SUB	50	  50 	ASP	A	292	 292 	HIS	B	Protein	A	6
FT	#SUB	50	  50 	ASP	A	294	 294 	ILE	B	Protein	B	2
FT	#SUB	51	  51 	SER	A	215	 215 	PHE	B	Protein	B	1
FT	#SUB	51	  51 	SER	A	292	 292 	HIS	B	Protein	S	1
FT	#SUB	51	  51 	SER	A	294	 294 	ILE	B	Protein	A	2
FT	#SUB	52	  52 	PRO	A	210	 210 	HIS	B	Protein	S	1
FT	#SUB	52	  52 	PRO	A	212	 212 	SER	B	Protein	S	1
FT	#SUB	52	  52 	PRO	A	251	 251 	GLU	B	Protein	S	3
FT	#SUB	52	  52 	PRO	A	294	 294 	ILE	B	Protein	S	1
FT	#SUB	55	  55 	MET	A	213	 213 	PRO	B	Protein	S	2
FT	#SUB	72	  72 	LYS	A	213	 213 	PRO	B	Protein	S	3
FT	#SUB	79	  79 	CYS	A	231	 231 	PRO	B	Protein	A	3
FT	#SUB	81	  81 	GLU	A	230	 230 	LEU	B	Protein	A	4
FT	#SUB	108	 108 	PHE	A	213	 213 	PRO	B	Protein	S	4
FT	#SUB	109	 109 	ASP	A	213	 213 	PRO	B	Protein	S	2
FT	#SUB	112	 112 	LEU	A	213	 213 	PRO	B	Protein	S	3
FT	#SUB	112	 112 	LEU	A	214	 214 	GLY	B	Protein	S	2
FT	#SUB	116	 116 	GLN	A	214	 214 	GLY	B	Protein	S	1
FT	#SUB	124	 124 	ALA	A	99	  99 	TYR	B	Protein	S	1
FT	#SUB	129	 129 	HIS	A	89	  89 	GLU	B	Protein	S	1
FT	#SUB	129	 129 	HIS	A	93	  93 	ASP	B	Protein	S	5
FT	#SUB	129	 129 	HIS	A	99	  99 	TYR	B	Protein	S	2
FT	#SUB	362	 362 	LYS	A	90	  90 	LEU	B	Protein	S	1
FT	#SUB	199	 199 	TYR	A	393	 393 	PRO	C	Protein	S	3
FT	#SUB	199	 199 	TYR	A	394	 394 	HIS	C	Protein	S	6
FT	#SUB	201	 201 	PRO	A	392	 392 	PHE	C	Protein	S	3
FT	#SUB	239	 239 	ARG	A	300	 300 	PHE	C	Protein	S	4
FT	#SUB	239	 239 	ARG	A	389	 389 	ILE	C	Protein	S	1
FT	#SUB	239	 239 	ARG	A	391	 391 	TYR	C	Protein	S	5
FT	#SUB	239	 239 	ARG	A	392	 392 	PHE	C	Protein	S	8
FT	#HET	50	  50 	ASP	A	8	700 	J38	B	A	3
FT	#HET	100	 100 	ASP	A	4	700 	J38	A	S	3
FT	#HET	141	 141 	HIS	A	4	700 	J38	A	S	3
FT	#HET	142	 142 	HIS	A	4	700 	J38	A	S	7
FT	#HET	150	 150 	GLY	A	4	700 	J38	A	B	4
FT	#HET	151	 151 	PHE	A	4	700 	J38	A	S	8
FT	#HET	184	 184 	ASP	A	3	601 	K	A	A	5
FT	#HET	185	 185 	LEU	A	3	601 	K	A	B	1
FT	#HET	186	 186 	ASP	A	1	500 	ZN	A	S	3
FT	#HET	186	 186 	ASP	A	3	601 	K	A	B	4
FT	#HET	186	 186 	ASP	A	4	700 	J38	A	S	3
FT	#HET	188	 188 	HIS	A	1	500 	ZN	A	A	5
FT	#HET	188	 188 	HIS	A	3	601 	K	A	B	2
FT	#HET	188	 188 	HIS	A	4	700 	J38	A	S	15
FT	#HET	197	 197 	PHE	A	2	600 	K	A	A	3
FT	#HET	200	 200 	SER	A	2	600 	K	A	B	2
FT	#HET	203	 203 	VAL	A	2	600 	K	A	B	2
FT	#HET	207	 207 	SER	A	3	601 	K	A	S	2
FT	#HET	208	 208 	VAL	A	3	601 	K	A	B	3
FT	#HET	209	 209 	HIS	A	3	601 	K	A	S	1
FT	#HET	216	 216 	PHE	A	4	700 	J38	A	S	10
FT	#HET	243	 243 	SER	A	2	600 	K	A	A	3
FT	#HET	285	 285 	ASP	A	1	500 	ZN	A	S	3
FT	#HET	285	 285 	ASP	A	4	700 	J38	A	S	1
FT	#HET	292	 292 	HIS	A	4	700 	J38	A	S	5
FT	#HET	341	 341 	TYR	A	4	700 	J38	A	S	5
FT	DISORDER	1	1
FT	DISORDER	170	177
FT	DISORDER	224	229
FT	DISORDER	304	314
FT	DISORDER	394	401
FT	DISORDER	428	446
CC	SEQUENCE	393 AA (ATOM);
CC	SVGIVYGDQY RQLCCSSPKF GDRYALVMDL INAYKLIPEL SRVPPLQWDS PSRMYEAVTA
CC	FHSTEYVDAL KKLQMLHCEE KELTADDELL MDSFSLNYDC PGFPSVFDYS LAAVQGSLAA
CC	ASALICRHCE VVINWGGGWH HAKRSEASGF CYLNDIVLAI HRLVSSTPTR VLYVDLDLHH
CC	GDGVEEAFWY SPRVVTFSVH HASPGFFPGT GTWNLPIFLN GAGRGRFSAF NLPLEEGIND
CC	LDWSNAIGPI LDSLNIVIQP SYVVVQCGAD CLATDPHRIF RLTNFYPNSL SGYLYAIKKI
CC	LSWKVPTLIL GGGGYNFPDT ARLWTRVTAL TIEEVKGKKM TISPEIPEHS YFSRYGPDFE
CC	LDIDYFPDSI QKHHRRILEQ LRNYADLNKL IYD
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MSVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWD
CC	ATOM   -SVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWD
CC	        *************************************************
CC	SEQRES SPSRMYEAVTAFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYD
CC	ATOM   SPSRMYEAVTAFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYD
CC	       **************************************************
CC	SEQRES CPGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASG
CC	ATOM   CPGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASG
CC	       **************************************************
CC	SEQRES FCYLNDIVLAIHRLVSSTPPETSPNRQTRVLYVDLDLHHGDGVEEAFWYS
CC	ATOM   FCYLNDIVLAIHRLVSSTP--------TRVLYVDLDLHHGDGVEEAFWYS
CC	       *******************        ***********************
CC	SEQRES PRVVTFSVHHASPGFFPGTGTWNMVDNDKLPIFLNGAGRGRFSAFNLPLE
CC	ATOM   PRVVTFSVHHASPGFFPGTGTWN------LPIFLNGAGRGRFSAFNLPLE
CC	       ***********************      *********************
CC	SEQRES EGINDLDWSNAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNF
CC	ATOM   EGINDLDWSNAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNF
CC	       **************************************************
CC	SEQRES YPNLNLDSDCDSECSLSGYLYAIKKILSWKVPTLILGGGGYNFPDTARLW
CC	ATOM   YPN-----------SLSGYLYAIKKILSWKVPTLILGGGGYNFPDTARLW
CC	       ***           ************************************
CC	SEQRES TRVTALTIEEVKGKKMTISPEIPEHSYFSRYGPDFELDIDYFPHESHNKT
CC	ATOM   TRVTALTIEEVKGKKMTISPEIPEHSYFSRYGPDFELDIDYFP-------
CC	       *******************************************       
CC	SEQRES LDSIQKHHRRILEQLRNYADLNKLIYDYDQVYQLYNLTGMGSLVPR
CC	ATOM   -DSIQKHHRRILEQLRNYADLNKLIYD-------------------
CC	        **************************                   
SQ	SEQUENCE	446 AA;      MW;         CN;
	MSVGIVYGDQ YRQLCCSSPK FGDRYALVMD LINAYKLIPE LSRVPPLQWD SPSRMYEAVT
	AFHSTEYVDA LKKLQMLHCE EKELTADDEL LMDSFSLNYD CPGFPSVFDY SLAAVQGSLA
	AASALICRHC EVVINWGGGW HHAKRSEASG FCYLNDIVLA IHRLVSSTPP ETSPNRQTRV
	LYVDLDLHHG DGVEEAFWYS PRVVTFSVHH ASPGFFPGTG TWNMVDNDKL PIFLNGAGRG
	RFSAFNLPLE EGINDLDWSN AIGPILDSLN IVIQPSYVVV QCGADCLATD PHRIFRLTNF
	YPNLNLDSDC DSECSLSGYL YAIKKILSWK VPTLILGGGG YNFPDTARLW TRVTALTIEE
	VKGKKMTISP EIPEHSYFSR YGPDFELDID YFPHESHNKT LDSIQKHHRR ILEQLRNYAD
	LNKLIYDYDQ VYQLYNLTGM GSLVPR
//
ID	4BZ8B	STANDARD;	PRT;	446	AA.
DT	CONVERTED FROM PDB (SEQRES) 4BZ8
DE	HISTONE DEACETYLASE 8
OS	SCHISTOSOMA MANSONI
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.210
CC	R-Factor	0.180
FT	#SUB	89	  89 	GLU	B	129	 129 	HIS	A	Protein	S	1
FT	#SUB	90	  90 	LEU	B	39	  39 	PRO	A	Protein	S	1
FT	#SUB	90	  90 	LEU	B	40	  40 	GLU	A	Protein	S	2
FT	#SUB	90	  90 	LEU	B	41	  41 	LEU	A	Protein	S	2
FT	#SUB	90	  90 	LEU	B	42	  42 	SER	A	Protein	S	1
FT	#SUB	90	  90 	LEU	B	362	 362 	LYS	A	Protein	S	1
FT	#SUB	93	  93 	ASP	B	42	  42 	SER	A	Protein	S	5
FT	#SUB	93	  93 	ASP	B	129	 129 	HIS	A	Protein	S	5
FT	#SUB	96	  96 	SER	B	43	  43 	ARG	A	Protein	S	2
FT	#SUB	99	  99 	TYR	B	44	  44 	VAL	A	Protein	S	1
FT	#SUB	99	  99 	TYR	B	45	  45 	PRO	A	Protein	S	3
FT	#SUB	99	  99 	TYR	B	124	 124 	ALA	A	Protein	S	1
FT	#SUB	99	  99 	TYR	B	129	 129 	HIS	A	Protein	S	2
FT	#SUB	147	 147 	GLU	B	43	  43 	ARG	A	Protein	S	3
FT	#SUB	210	 210 	HIS	B	52	  52 	PRO	A	Protein	S	1
FT	#SUB	212	 212 	SER	B	52	  52 	PRO	A	Protein	S	1
FT	#SUB	213	 213 	PRO	B	55	  55 	MET	A	Protein	B	2
FT	#SUB	213	 213 	PRO	B	72	  72 	LYS	A	Protein	S	3
FT	#SUB	213	 213 	PRO	B	108	 108 	PHE	A	Protein	S	4
FT	#SUB	213	 213 	PRO	B	109	 109 	ASP	A	Protein	S	2
FT	#SUB	213	 213 	PRO	B	112	 112 	LEU	A	Protein	A	3
FT	#SUB	214	 214 	GLY	B	48	  48 	GLN	A	Protein	B	4
FT	#SUB	214	 214 	GLY	B	49	  49 	TRP	A	Protein	B	6
FT	#SUB	214	 214 	GLY	B	112	 112 	LEU	A	Protein	B	2
FT	#SUB	214	 214 	GLY	B	116	 116 	GLN	A	Protein	B	1
FT	#SUB	215	 215 	PHE	B	49	  49 	TRP	A	Protein	A	2
FT	#SUB	215	 215 	PHE	B	50	  50 	ASP	A	Protein	S	4
FT	#SUB	215	 215 	PHE	B	51	  51 	SER	A	Protein	S	1
FT	#SUB	216	 216 	PHE	B	48	  48 	GLN	A	Protein	A	7
FT	#SUB	217	 217 	PRO	B	48	  48 	GLN	A	Protein	B	3
FT	#SUB	218	 218 	GLY	B	10	  10 	GLN	A	Protein	B	3
FT	#SUB	219	 219 	THR	B	10	  10 	GLN	A	Protein	A	2
FT	#SUB	230	 230 	LEU	B	81	  81 	GLU	A	Protein	S	4
FT	#SUB	231	 231 	PRO	B	79	  79 	CYS	A	Protein	S	3
FT	#SUB	251	 251 	GLU	B	52	  52 	PRO	A	Protein	S	3
FT	#SUB	292	 292 	HIS	B	50	  50 	ASP	A	Protein	A	6
FT	#SUB	292	 292 	HIS	B	51	  51 	SER	A	Protein	B	1
FT	#SUB	294	 294 	ILE	B	50	  50 	ASP	A	Protein	S	2
FT	#SUB	294	 294 	ILE	B	51	  51 	SER	A	Protein	S	2
FT	#SUB	294	 294 	ILE	B	52	  52 	PRO	A	Protein	S	1
FT	#SUB	300	 300 	PHE	B	239	 239 	ARG	D	Protein	S	2
FT	#SUB	370	 370 	PRO	B	423	 423 	LYS	D	Protein	S	2
FT	#SUB	386	 386 	GLU	B	423	 423 	LYS	D	Protein	S	1
FT	#SUB	389	 389 	ILE	B	239	 239 	ARG	D	Protein	B	1
FT	#SUB	391	 391 	TYR	B	239	 239 	ARG	D	Protein	B	5
FT	#SUB	392	 392 	PHE	B	201	 201 	PRO	D	Protein	S	3
FT	#SUB	392	 392 	PHE	B	202	 202 	ARG	D	Protein	S	2
FT	#SUB	392	 392 	PHE	B	239	 239 	ARG	D	Protein	S	9
FT	#SUB	393	 393 	PRO	B	199	 199 	TYR	D	Protein	B	3
FT	#SUB	393	 393 	PRO	B	239	 239 	ARG	D	Protein	S	1
FT	#SUB	394	 394 	HIS	B	199	 199 	TYR	D	Protein	A	6
FT	#HET	100	 100 	ASP	B	8	700 	J38	B	S	1
FT	#HET	141	 141 	HIS	B	8	700 	J38	B	S	4
FT	#HET	142	 142 	HIS	B	8	700 	J38	B	S	7
FT	#HET	150	 150 	GLY	B	8	700 	J38	B	B	4
FT	#HET	151	 151 	PHE	B	8	700 	J38	B	S	9
FT	#HET	184	 184 	ASP	B	7	601 	K	B	A	5
FT	#HET	186	 186 	ASP	B	5	500 	ZN	B	S	3
FT	#HET	186	 186 	ASP	B	7	601 	K	B	A	5
FT	#HET	186	 186 	ASP	B	8	700 	J38	B	S	3
FT	#HET	188	 188 	HIS	B	5	500 	ZN	B	A	5
FT	#HET	188	 188 	HIS	B	7	601 	K	B	B	2
FT	#HET	188	 188 	HIS	B	8	700 	J38	B	S	14
FT	#HET	197	 197 	PHE	B	6	600 	K	B	A	3
FT	#HET	200	 200 	SER	B	6	600 	K	B	B	2
FT	#HET	203	 203 	VAL	B	6	600 	K	B	B	2
FT	#HET	207	 207 	SER	B	7	601 	K	B	S	1
FT	#HET	208	 208 	VAL	B	7	601 	K	B	B	3
FT	#HET	209	 209 	HIS	B	7	601 	K	B	S	1
FT	#HET	216	 216 	PHE	B	8	700 	J38	B	S	9
FT	#HET	243	 243 	SER	B	6	600 	K	B	A	4
FT	#HET	285	 285 	ASP	B	5	500 	ZN	B	S	3
FT	#HET	285	 285 	ASP	B	8	700 	J38	B	S	2
FT	#HET	292	 292 	HIS	B	8	700 	J38	B	S	5
FT	#HET	341	 341 	TYR	B	8	700 	J38	B	S	6
FT	DISORDER	1	1
FT	DISORDER	169	176
FT	DISORDER	224	229
FT	DISORDER	303	314
FT	DISORDER	395	398
CC	SEQUENCE	415 AA (ATOM);
CC	SVGIVYGDQY RQLCCSSPKF GDRYALVMDL INAYKLIPEL SRVPPLQWDS PSRMYEAVTA
CC	FHSTEYVDAL KKLQMLHCEE KELTADDELL MDSFSLNYDC PGFPSVFDYS LAAVQGSLAA
CC	ASALICRHCE VVINWGGGWH HAKRSEASGF CYLNDIVLAI HRLVSSTQTR VLYVDLDLHH
CC	GDGVEEAFWY SPRVVTFSVH HASPGFFPGT GTWNLPIFLN GAGRGRFSAF NLPLEEGIND
CC	LDWSNAIGPI LDSLNIVIQP SYVVVQCGAD CLATDPHRIF RLTNFYPSLS GYLYAIKKIL
CC	SWKVPTLILG GGGYNFPDTA RLWTRVTALT IEEVKGKKMT ISPEIPEHSY FSRYGPDFEL
CC	DIDYFPHKTL DSIQKHHRRI LEQLRNYADL NKLIYDYDQV YQLYNLTGMG SLVPR
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MSVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWD
CC	ATOM   -SVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWD
CC	        *************************************************
CC	SEQRES SPSRMYEAVTAFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYD
CC	ATOM   SPSRMYEAVTAFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYD
CC	       **************************************************
CC	SEQRES CPGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASG
CC	ATOM   CPGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASG
CC	       **************************************************
CC	SEQRES FCYLNDIVLAIHRLVSSTPPETSPNRQTRVLYVDLDLHHGDGVEEAFWYS
CC	ATOM   FCYLNDIVLAIHRLVSST--------QTRVLYVDLDLHHGDGVEEAFWYS
CC	       ******************        ************************
CC	SEQRES PRVVTFSVHHASPGFFPGTGTWNMVDNDKLPIFLNGAGRGRFSAFNLPLE
CC	ATOM   PRVVTFSVHHASPGFFPGTGTWN------LPIFLNGAGRGRFSAFNLPLE
CC	       ***********************      *********************
CC	SEQRES EGINDLDWSNAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNF
CC	ATOM   EGINDLDWSNAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNF
CC	       **************************************************
CC	SEQRES YPNLNLDSDCDSECSLSGYLYAIKKILSWKVPTLILGGGGYNFPDTARLW
CC	ATOM   YP------------SLSGYLYAIKKILSWKVPTLILGGGGYNFPDTARLW
CC	       **            ************************************
CC	SEQRES TRVTALTIEEVKGKKMTISPEIPEHSYFSRYGPDFELDIDYFPHESHNKT
CC	ATOM   TRVTALTIEEVKGKKMTISPEIPEHSYFSRYGPDFELDIDYFPH----KT
CC	       ********************************************    **
CC	SEQRES LDSIQKHHRRILEQLRNYADLNKLIYDYDQVYQLYNLTGMGSLVPR
CC	ATOM   LDSIQKHHRRILEQLRNYADLNKLIYDYDQVYQLYNLTGMGSLVPR
CC	       **********************************************
SQ	SEQUENCE	446 AA;      MW;         CN;
	MSVGIVYGDQ YRQLCCSSPK FGDRYALVMD LINAYKLIPE LSRVPPLQWD SPSRMYEAVT
	AFHSTEYVDA LKKLQMLHCE EKELTADDEL LMDSFSLNYD CPGFPSVFDY SLAAVQGSLA
	AASALICRHC EVVINWGGGW HHAKRSEASG FCYLNDIVLA IHRLVSSTPP ETSPNRQTRV
	LYVDLDLHHG DGVEEAFWYS PRVVTFSVHH ASPGFFPGTG TWNMVDNDKL PIFLNGAGRG
	RFSAFNLPLE EGINDLDWSN AIGPILDSLN IVIQPSYVVV QCGADCLATD PHRIFRLTNF
	YPNLNLDSDC DSECSLSGYL YAIKKILSWK VPTLILGGGG YNFPDTARLW TRVTALTIEE
	VKGKKMTISP EIPEHSYFSR YGPDFELDID YFPHESHNKT LDSIQKHHRR ILEQLRNYAD
	LNKLIYDYDQ VYQLYNLTGM GSLVPR
//
ID	4BZ8C	STANDARD;	PRT;	446	AA.
DT	CONVERTED FROM PDB (SEQRES) 4BZ8
DE	HISTONE DEACETYLASE 8
OS	SCHISTOSOMA MANSONI
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.210
CC	R-Factor	0.180
FT	#SUB	300	 300 	PHE	C	239	 239 	ARG	A	Protein	S	4
FT	#SUB	389	 389 	ILE	C	239	 239 	ARG	A	Protein	B	1
FT	#SUB	391	 391 	TYR	C	239	 239 	ARG	A	Protein	B	5
FT	#SUB	392	 392 	PHE	C	201	 201 	PRO	A	Protein	S	3
FT	#SUB	392	 392 	PHE	C	239	 239 	ARG	A	Protein	S	8
FT	#SUB	393	 393 	PRO	C	199	 199 	TYR	A	Protein	B	3
FT	#SUB	394	 394 	HIS	C	199	 199 	TYR	A	Protein	A	6
FT	#SUB	89	  89 	GLU	C	129	 129 	HIS	D	Protein	S	1
FT	#SUB	90	  90 	LEU	C	39	  39 	PRO	D	Protein	S	1
FT	#SUB	90	  90 	LEU	C	40	  40 	GLU	D	Protein	S	2
FT	#SUB	90	  90 	LEU	C	41	  41 	LEU	D	Protein	S	2
FT	#SUB	90	  90 	LEU	C	42	  42 	SER	D	Protein	S	2
FT	#SUB	90	  90 	LEU	C	362	 362 	LYS	D	Protein	S	2
FT	#SUB	93	  93 	ASP	C	42	  42 	SER	D	Protein	S	4
FT	#SUB	93	  93 	ASP	C	129	 129 	HIS	D	Protein	S	6
FT	#SUB	99	  99 	TYR	C	44	  44 	VAL	D	Protein	S	1
FT	#SUB	99	  99 	TYR	C	45	  45 	PRO	D	Protein	S	2
FT	#SUB	99	  99 	TYR	C	124	 124 	ALA	D	Protein	S	1
FT	#SUB	99	  99 	TYR	C	129	 129 	HIS	D	Protein	S	2
FT	#SUB	210	 210 	HIS	C	52	  52 	PRO	D	Protein	S	1
FT	#SUB	212	 212 	SER	C	52	  52 	PRO	D	Protein	S	1
FT	#SUB	213	 213 	PRO	C	55	  55 	MET	D	Protein	B	2
FT	#SUB	213	 213 	PRO	C	108	 108 	PHE	D	Protein	S	4
FT	#SUB	213	 213 	PRO	C	109	 109 	ASP	D	Protein	S	2
FT	#SUB	213	 213 	PRO	C	112	 112 	LEU	D	Protein	A	3
FT	#SUB	214	 214 	GLY	C	48	  48 	GLN	D	Protein	B	4
FT	#SUB	214	 214 	GLY	C	49	  49 	TRP	D	Protein	B	6
FT	#SUB	214	 214 	GLY	C	112	 112 	LEU	D	Protein	B	2
FT	#SUB	214	 214 	GLY	C	116	 116 	GLN	D	Protein	B	1
FT	#SUB	215	 215 	PHE	C	48	  48 	GLN	D	Protein	B	2
FT	#SUB	215	 215 	PHE	C	49	  49 	TRP	D	Protein	A	2
FT	#SUB	215	 215 	PHE	C	50	  50 	ASP	D	Protein	S	4
FT	#SUB	216	 216 	PHE	C	48	  48 	GLN	D	Protein	A	8
FT	#SUB	216	 216 	PHE	C	49	  49 	TRP	D	Protein	B	1
FT	#SUB	217	 217 	PRO	C	48	  48 	GLN	D	Protein	B	3
FT	#SUB	218	 218 	GLY	C	10	  10 	GLN	D	Protein	B	1
FT	#SUB	218	 218 	GLY	C	48	  48 	GLN	D	Protein	B	1
FT	#SUB	224	 224 	MET	C	79	  79 	CYS	D	Protein	S	2
FT	#SUB	224	 224 	MET	C	105	 105 	PRO	D	Protein	S	6
FT	#SUB	224	 224 	MET	C	106	 106 	SER	D	Protein	S	1
FT	#SUB	230	 230 	LEU	C	79	  79 	CYS	D	Protein	S	2
FT	#SUB	230	 230 	LEU	C	80	  80 	GLU	D	Protein	S	2
FT	#SUB	230	 230 	LEU	C	81	  81 	GLU	D	Protein	S	2
FT	#SUB	231	 231 	PRO	C	79	  79 	CYS	D	Protein	S	4
FT	#SUB	251	 251 	GLU	C	52	  52 	PRO	D	Protein	S	5
FT	#SUB	292	 292 	HIS	C	50	  50 	ASP	D	Protein	A	7
FT	#SUB	292	 292 	HIS	C	51	  51 	SER	D	Protein	B	1
FT	#SUB	294	 294 	ILE	C	50	  50 	ASP	D	Protein	S	1
FT	#SUB	294	 294 	ILE	C	51	  51 	SER	D	Protein	S	2
FT	#HET	141	 141 	HIS	C	12	700 	J38	C	S	4
FT	#HET	142	 142 	HIS	C	12	700 	J38	C	S	5
FT	#HET	150	 150 	GLY	C	12	700 	J38	C	B	4
FT	#HET	151	 151 	PHE	C	12	700 	J38	C	S	9
FT	#HET	184	 184 	ASP	C	10	600 	K	C	A	5
FT	#HET	185	 185 	LEU	C	10	600 	K	C	B	1
FT	#HET	186	 186 	ASP	C	9	500 	ZN	C	S	3
FT	#HET	186	 186 	ASP	C	10	600 	K	C	A	5
FT	#HET	186	 186 	ASP	C	12	700 	J38	C	S	3
FT	#HET	188	 188 	HIS	C	9	500 	ZN	C	A	5
FT	#HET	188	 188 	HIS	C	10	600 	K	C	B	2
FT	#HET	188	 188 	HIS	C	12	700 	J38	C	S	17
FT	#HET	197	 197 	PHE	C	11	601 	K	C	A	3
FT	#HET	200	 200 	SER	C	11	601 	K	C	B	2
FT	#HET	203	 203 	VAL	C	11	601 	K	C	B	2
FT	#HET	207	 207 	SER	C	10	600 	K	C	S	1
FT	#HET	208	 208 	VAL	C	10	600 	K	C	B	3
FT	#HET	209	 209 	HIS	C	10	600 	K	C	S	1
FT	#HET	216	 216 	PHE	C	12	700 	J38	C	S	9
FT	#HET	243	 243 	SER	C	11	601 	K	C	A	4
FT	#HET	285	 285 	ASP	C	9	500 	ZN	C	S	3
FT	#HET	285	 285 	ASP	C	12	700 	J38	C	S	1
FT	#HET	292	 292 	HIS	C	12	700 	J38	C	S	5
FT	#HET	341	 341 	TYR	C	12	700 	J38	C	S	5
FT	DISORDER	1	1
FT	DISORDER	81	82
FT	DISORDER	168	177
FT	DISORDER	225	227
FT	DISORDER	303	314
FT	DISORDER	395	399
CC	SEQUENCE	413 AA (ATOM);
CC	SVGIVYGDQY RQLCCSSPKF GDRYALVMDL INAYKLIPEL SRVPPLQWDS PSRMYEAVTA
CC	FHSTEYVDAL KKLQMLHCEE LTADDELLMD SFSLNYDCPG FPSVFDYSLA AVQGSLAAAS
CC	ALICRHCEVV INWGGGWHHA KRSEASGFCY LNDIVLAIHR LVSSTRVLYV DLDLHHGDGV
CC	EEAFWYSPRV VTFSVHHASP GFFPGTGTWN MDKLPIFLNG AGRGRFSAFN LPLEEGINDL
CC	DWSNAIGPIL DSLNIVIQPS YVVVQCGADC LATDPHRIFR LTNFYPSLSG YLYAIKKILS
CC	WKVPTLILGG GGYNFPDTAR LWTRVTALTI EEVKGKKMTI SPEIPEHSYF SRYGPDFELD
CC	IDYFPHTLDS IQKHHRRILE QLRNYADLNK LIYDYDQVYQ LYNLTGMGSL VPR
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MSVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWD
CC	ATOM   -SVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWD
CC	        *************************************************
CC	SEQRES SPSRMYEAVTAFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYD
CC	ATOM   SPSRMYEAVTAFHSTEYVDALKKLQMLHCE--ELTADDELLMDSFSLNYD
CC	       ******************************  ******************
CC	SEQRES CPGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASG
CC	ATOM   CPGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASG
CC	       **************************************************
CC	SEQRES FCYLNDIVLAIHRLVSSTPPETSPNRQTRVLYVDLDLHHGDGVEEAFWYS
CC	ATOM   FCYLNDIVLAIHRLVSS----------TRVLYVDLDLHHGDGVEEAFWYS
CC	       *****************          ***********************
CC	SEQRES PRVVTFSVHHASPGFFPGTGTWNMVDNDKLPIFLNGAGRGRFSAFNLPLE
CC	ATOM   PRVVTFSVHHASPGFFPGTGTWNM---DKLPIFLNGAGRGRFSAFNLPLE
CC	       ************************   ***********************
CC	SEQRES EGINDLDWSNAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNF
CC	ATOM   EGINDLDWSNAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNF
CC	       **************************************************
CC	SEQRES YPNLNLDSDCDSECSLSGYLYAIKKILSWKVPTLILGGGGYNFPDTARLW
CC	ATOM   YP------------SLSGYLYAIKKILSWKVPTLILGGGGYNFPDTARLW
CC	       **            ************************************
CC	SEQRES TRVTALTIEEVKGKKMTISPEIPEHSYFSRYGPDFELDIDYFPHESHNKT
CC	ATOM   TRVTALTIEEVKGKKMTISPEIPEHSYFSRYGPDFELDIDYFPH-----T
CC	       ********************************************     *
CC	SEQRES LDSIQKHHRRILEQLRNYADLNKLIYDYDQVYQLYNLTGMGSLVPR
CC	ATOM   LDSIQKHHRRILEQLRNYADLNKLIYDYDQVYQLYNLTGMGSLVPR
CC	       **********************************************
SQ	SEQUENCE	446 AA;      MW;         CN;
	MSVGIVYGDQ YRQLCCSSPK FGDRYALVMD LINAYKLIPE LSRVPPLQWD SPSRMYEAVT
	AFHSTEYVDA LKKLQMLHCE EKELTADDEL LMDSFSLNYD CPGFPSVFDY SLAAVQGSLA
	AASALICRHC EVVINWGGGW HHAKRSEASG FCYLNDIVLA IHRLVSSTPP ETSPNRQTRV
	LYVDLDLHHG DGVEEAFWYS PRVVTFSVHH ASPGFFPGTG TWNMVDNDKL PIFLNGAGRG
	RFSAFNLPLE EGINDLDWSN AIGPILDSLN IVIQPSYVVV QCGADCLATD PHRIFRLTNF
	YPNLNLDSDC DSECSLSGYL YAIKKILSWK VPTLILGGGG YNFPDTARLW TRVTALTIEE
	VKGKKMTISP EIPEHSYFSR YGPDFELDID YFPHESHNKT LDSIQKHHRR ILEQLRNYAD
	LNKLIYDYDQ VYQLYNLTGM GSLVPR
//
ID	4BZ8D	STANDARD;	PRT;	446	AA.
DT	CONVERTED FROM PDB (SEQRES) 4BZ8
DE	HISTONE DEACETYLASE 8
OS	SCHISTOSOMA MANSONI
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.210
CC	R-Factor	0.180
FT	#SUB	199	 199 	TYR	D	393	 393 	PRO	B	Protein	S	3
FT	#SUB	199	 199 	TYR	D	394	 394 	HIS	B	Protein	S	6
FT	#SUB	201	 201 	PRO	D	392	 392 	PHE	B	Protein	S	3
FT	#SUB	202	 202 	ARG	D	392	 392 	PHE	B	Protein	S	2
FT	#SUB	239	 239 	ARG	D	300	 300 	PHE	B	Protein	S	2
FT	#SUB	239	 239 	ARG	D	389	 389 	ILE	B	Protein	S	1
FT	#SUB	239	 239 	ARG	D	391	 391 	TYR	B	Protein	S	5
FT	#SUB	239	 239 	ARG	D	392	 392 	PHE	B	Protein	S	9
FT	#SUB	239	 239 	ARG	D	393	 393 	PRO	B	Protein	S	1
FT	#SUB	423	 423 	LYS	D	370	 370 	PRO	B	Protein	S	2
FT	#SUB	423	 423 	LYS	D	386	 386 	GLU	B	Protein	S	1
FT	#SUB	10	  10 	GLN	D	218	 218 	GLY	C	Protein	S	1
FT	#SUB	39	  39 	PRO	D	90	  90 	LEU	C	Protein	B	1
FT	#SUB	40	  40 	GLU	D	90	  90 	LEU	C	Protein	B	2
FT	#SUB	41	  41 	LEU	D	90	  90 	LEU	C	Protein	B	2
FT	#SUB	42	  42 	SER	D	90	  90 	LEU	C	Protein	B	2
FT	#SUB	42	  42 	SER	D	93	  93 	ASP	C	Protein	S	4
FT	#SUB	44	  44 	VAL	D	99	  99 	TYR	C	Protein	S	1
FT	#SUB	45	  45 	PRO	D	99	  99 	TYR	C	Protein	S	2
FT	#SUB	48	  48 	GLN	D	214	 214 	GLY	C	Protein	A	4
FT	#SUB	48	  48 	GLN	D	215	 215 	PHE	C	Protein	S	2
FT	#SUB	48	  48 	GLN	D	216	 216 	PHE	C	Protein	S	8
FT	#SUB	48	  48 	GLN	D	217	 217 	PRO	C	Protein	S	3
FT	#SUB	48	  48 	GLN	D	218	 218 	GLY	C	Protein	S	1
FT	#SUB	49	  49 	TRP	D	214	 214 	GLY	C	Protein	A	6
FT	#SUB	49	  49 	TRP	D	215	 215 	PHE	C	Protein	B	2
FT	#SUB	49	  49 	TRP	D	216	 216 	PHE	C	Protein	B	1
FT	#SUB	50	  50 	ASP	D	215	 215 	PHE	C	Protein	B	4
FT	#SUB	50	  50 	ASP	D	292	 292 	HIS	C	Protein	A	7
FT	#SUB	50	  50 	ASP	D	294	 294 	ILE	C	Protein	B	1
FT	#SUB	51	  51 	SER	D	292	 292 	HIS	C	Protein	S	1
FT	#SUB	51	  51 	SER	D	294	 294 	ILE	C	Protein	A	2
FT	#SUB	52	  52 	PRO	D	210	 210 	HIS	C	Protein	S	1
FT	#SUB	52	  52 	PRO	D	212	 212 	SER	C	Protein	S	1
FT	#SUB	52	  52 	PRO	D	251	 251 	GLU	C	Protein	S	5
FT	#SUB	55	  55 	MET	D	213	 213 	PRO	C	Protein	S	2
FT	#SUB	79	  79 	CYS	D	224	 224 	MET	C	Protein	S	2
FT	#SUB	79	  79 	CYS	D	230	 230 	LEU	C	Protein	B	2
FT	#SUB	79	  79 	CYS	D	231	 231 	PRO	C	Protein	A	4
FT	#SUB	80	  80 	GLU	D	230	 230 	LEU	C	Protein	B	2
FT	#SUB	81	  81 	GLU	D	230	 230 	LEU	C	Protein	A	2
FT	#SUB	105	 105 	PRO	D	224	 224 	MET	C	Protein	A	6
FT	#SUB	106	 106 	SER	D	224	 224 	MET	C	Protein	S	1
FT	#SUB	108	 108 	PHE	D	213	 213 	PRO	C	Protein	S	4
FT	#SUB	109	 109 	ASP	D	213	 213 	PRO	C	Protein	S	2
FT	#SUB	112	 112 	LEU	D	213	 213 	PRO	C	Protein	S	3
FT	#SUB	112	 112 	LEU	D	214	 214 	GLY	C	Protein	S	2
FT	#SUB	116	 116 	GLN	D	214	 214 	GLY	C	Protein	S	1
FT	#SUB	124	 124 	ALA	D	99	  99 	TYR	C	Protein	S	1
FT	#SUB	129	 129 	HIS	D	89	  89 	GLU	C	Protein	S	1
FT	#SUB	129	 129 	HIS	D	93	  93 	ASP	C	Protein	S	6
FT	#SUB	129	 129 	HIS	D	99	  99 	TYR	C	Protein	S	2
FT	#SUB	362	 362 	LYS	D	90	  90 	LEU	C	Protein	S	2
FT	#HET	50	  50 	ASP	D	12	700 	J38	C	A	4
FT	#HET	100	 100 	ASP	D	16	700 	J38	D	S	4
FT	#HET	141	 141 	HIS	D	16	700 	J38	D	S	3
FT	#HET	142	 142 	HIS	D	16	700 	J38	D	S	4
FT	#HET	150	 150 	GLY	D	16	700 	J38	D	B	3
FT	#HET	151	 151 	PHE	D	16	700 	J38	D	S	9
FT	#HET	184	 184 	ASP	D	15	601 	K	D	A	5
FT	#HET	185	 185 	LEU	D	15	601 	K	D	B	1
FT	#HET	186	 186 	ASP	D	13	500 	ZN	D	S	3
FT	#HET	186	 186 	ASP	D	15	601 	K	D	A	5
FT	#HET	186	 186 	ASP	D	16	700 	J38	D	S	3
FT	#HET	188	 188 	HIS	D	13	500 	ZN	D	A	5
FT	#HET	188	 188 	HIS	D	15	601 	K	D	B	2
FT	#HET	188	 188 	HIS	D	16	700 	J38	D	S	14
FT	#HET	197	 197 	PHE	D	14	600 	K	D	A	3
FT	#HET	200	 200 	SER	D	14	600 	K	D	B	2
FT	#HET	203	 203 	VAL	D	14	600 	K	D	B	2
FT	#HET	207	 207 	SER	D	15	601 	K	D	S	1
FT	#HET	208	 208 	VAL	D	15	601 	K	D	B	3
FT	#HET	209	 209 	HIS	D	15	601 	K	D	S	1
FT	#HET	216	 216 	PHE	D	16	700 	J38	D	S	7
FT	#HET	243	 243 	SER	D	14	600 	K	D	A	4
FT	#HET	285	 285 	ASP	D	13	500 	ZN	D	S	3
FT	#HET	285	 285 	ASP	D	16	700 	J38	D	S	2
FT	#HET	292	 292 	HIS	D	16	700 	J38	D	S	5
FT	#HET	341	 341 	TYR	D	16	700 	J38	D	S	6
FT	DISORDER	1	1
FT	DISORDER	168	176
FT	DISORDER	224	230
FT	DISORDER	303	314
FT	DISORDER	394	401
FT	DISORDER	432	446
CC	SEQUENCE	394 AA (ATOM);
CC	SVGIVYGDQY RQLCCSSPKF GDRYALVMDL INAYKLIPEL SRVPPLQWDS PSRMYEAVTA
CC	FHSTEYVDAL KKLQMLHCEE KELTADDELL MDSFSLNYDC PGFPSVFDYS LAAVQGSLAA
CC	ASALICRHCE VVINWGGGWH HAKRSEASGF CYLNDIVLAI HRLVSSQTRV LYVDLDLHHG
CC	DGVEEAFWYS PRVVTFSVHH ASPGFFPGTG TWNPIFLNGA GRGRFSAFNL PLEEGINDLD
CC	WSNAIGPILD SLNIVIQPSY VVVQCGADCL ATDPHRIFRL TNFYPSLSGY LYAIKKILSW
CC	KVPTLILGGG GYNFPDTARL WTRVTALTIE EVKGKKMTIS PEIPEHSYFS RYGPDFELDI
CC	DYFPDSIQKH HRRILEQLRN YADLNKLIYD YDQV
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MSVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWD
CC	ATOM   -SVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWD
CC	        *************************************************
CC	SEQRES SPSRMYEAVTAFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYD
CC	ATOM   SPSRMYEAVTAFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYD
CC	       **************************************************
CC	SEQRES CPGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASG
CC	ATOM   CPGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASG
CC	       **************************************************
CC	SEQRES FCYLNDIVLAIHRLVSSTPPETSPNRQTRVLYVDLDLHHGDGVEEAFWYS
CC	ATOM   FCYLNDIVLAIHRLVSS---------QTRVLYVDLDLHHGDGVEEAFWYS
CC	       *****************         ************************
CC	SEQRES PRVVTFSVHHASPGFFPGTGTWNMVDNDKLPIFLNGAGRGRFSAFNLPLE
CC	ATOM   PRVVTFSVHHASPGFFPGTGTWN-------PIFLNGAGRGRFSAFNLPLE
CC	       ***********************       ********************
CC	SEQRES EGINDLDWSNAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNF
CC	ATOM   EGINDLDWSNAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNF
CC	       **************************************************
CC	SEQRES YPNLNLDSDCDSECSLSGYLYAIKKILSWKVPTLILGGGGYNFPDTARLW
CC	ATOM   YP------------SLSGYLYAIKKILSWKVPTLILGGGGYNFPDTARLW
CC	       **            ************************************
CC	SEQRES TRVTALTIEEVKGKKMTISPEIPEHSYFSRYGPDFELDIDYFPHESHNKT
CC	ATOM   TRVTALTIEEVKGKKMTISPEIPEHSYFSRYGPDFELDIDYFP-------
CC	       *******************************************       
CC	SEQRES LDSIQKHHRRILEQLRNYADLNKLIYDYDQVYQLYNLTGMGSLVPR
CC	ATOM   -DSIQKHHRRILEQLRNYADLNKLIYDYDQV---------------
CC	        ******************************               
SQ	SEQUENCE	446 AA;      MW;         CN;
	MSVGIVYGDQ YRQLCCSSPK FGDRYALVMD LINAYKLIPE LSRVPPLQWD SPSRMYEAVT
	AFHSTEYVDA LKKLQMLHCE EKELTADDEL LMDSFSLNYD CPGFPSVFDY SLAAVQGSLA
	AASALICRHC EVVINWGGGW HHAKRSEASG FCYLNDIVLA IHRLVSSTPP ETSPNRQTRV
	LYVDLDLHHG DGVEEAFWYS PRVVTFSVHH ASPGFFPGTG TWNMVDNDKL PIFLNGAGRG
	RFSAFNLPLE EGINDLDWSN AIGPILDSLN IVIQPSYVVV QCGADCLATD PHRIFRLTNF
	YPNLNLDSDC DSECSLSGYL YAIKKILSWK VPTLILGGGG YNFPDTARLW TRVTALTIEE
	VKGKKMTISP EIPEHSYFSR YGPDFELDID YFPHESHNKT LDSIQKHHRR ILEQLRNYAD
	LNKLIYDYDQ VYQLYNLTGM GSLVPR
//