ID 3V8WA STANDARD; PRT; 266 AA. DT CONVERTED FROM PDB (SEQRES) 3V8W DE Tyrosine-protein kinase ITK/TSK OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.270 CC R-Factor 0.252 FT #SUB 1 355 GLY A 121 475 GLU B Protein B 2 FT #SUB 2 356 SER A 118 472 TYR B Protein S 1 FT #SUB 2 356 SER A 121 475 GLU B Protein B 6 FT #SUB 8 362 GLU A 256 610 ARG B Protein S 10 FT #SUB 28 382 TRP A 114 468 GLU B Protein S 4 FT #SUB 28 382 TRP A 255 609 LEU B Protein S 2 FT #SUB 29 383 LEU A 255 609 LEU B Protein S 2 FT #SUB 29 383 LEU A 259 613 ALA B Protein S 1 FT #SUB 31 385 LYS A 107 461 GLY B Protein S 3 FT #SUB 31 385 LYS A 110 464 LEU B Protein S 1 FT #SUB 31 385 LYS A 111 465 ASP B Protein S 4 FT #SUB 31 385 LYS A 114 468 GLU B Protein S 1 FT #SUB 32 386 ASP A 63 417 LYS B Protein S 4 FT #SUB 32 386 ASP A 111 465 ASP B Protein S 1 FT #SUB 32 386 ASP A 114 468 GLU B Protein S 4 FT #SUB 57 411 MET A 60 414 SER B Protein B 5 FT #SUB 57 411 MET A 118 472 TYR B Protein B 3 FT #SUB 58 412 LYS A 57 411 MET B Protein B 1 FT #SUB 58 412 LYS A 58 412 LYS B Protein B 5 FT #SUB 59 413 LEU A 60 414 SER B Protein B 3 FT #SUB 60 414 SER A 56 410 MET B Protein S 2 FT #SUB 60 414 SER A 57 411 MET B Protein A 5 FT #SUB 60 414 SER A 59 413 LEU B Protein S 3 FT #SUB 60 414 SER A 60 414 SER B Protein A 6 FT #SUB 60 414 SER A 66 420 GLN B Protein S 2 FT #SUB 61 415 HIS A 66 420 GLN B Protein B 7 FT #SUB 62 416 PRO A 66 420 GLN B Protein A 5 FT #SUB 62 416 PRO A 67 421 LEU B Protein S 1 FT #SUB 62 416 PRO A 68 422 TYR B Protein S 7 FT #SUB 63 417 LYS A 32 386 ASP B Protein S 3 FT #SUB 63 417 LYS A 68 422 TYR B Protein S 2 FT #SUB 66 420 GLN A 60 414 SER B Protein S 3 FT #SUB 66 420 GLN A 61 415 HIS B Protein S 7 FT #SUB 66 420 GLN A 62 416 PRO B Protein S 5 FT #SUB 66 420 GLN A 66 420 GLN B Protein S 11 FT #SUB 67 421 LEU A 62 416 PRO B Protein B 1 FT #SUB 68 422 TYR A 62 416 PRO B Protein S 6 FT #SUB 68 422 TYR A 63 417 LYS B Protein S 3 FT #SUB 68 422 TYR A 114 468 GLU B Protein S 2 FT #SUB 107 461 GLY A 31 385 LYS B Protein B 2 FT #SUB 110 464 LEU A 31 385 LYS B Protein S 1 FT #SUB 111 465 ASP A 31 385 LYS B Protein S 4 FT #SUB 111 465 ASP A 32 386 ASP B Protein S 1 FT #SUB 114 468 GLU A 28 382 TRP B Protein S 4 FT #SUB 114 468 GLU A 31 385 LYS B Protein S 1 FT #SUB 114 468 GLU A 32 386 ASP B Protein S 4 FT #SUB 114 468 GLU A 68 422 TYR B Protein S 1 FT #SUB 118 472 TYR A 2 356 SER B Protein S 1 FT #SUB 118 472 TYR A 57 411 MET B Protein S 3 FT #SUB 121 475 GLU A 1 355 GLY B Protein S 2 FT #SUB 121 475 GLU A 2 356 SER B Protein S 6 FT #SUB 255 609 LEU A 28 382 TRP B Protein S 2 FT #SUB 255 609 LEU A 29 383 LEU B Protein S 2 FT #SUB 256 610 ARG A 8 362 GLU B Protein S 11 FT #SUB 259 613 ALA A 29 383 LEU B Protein S 1 FT #HET 15 369 ILE A 1 701 0G2 A A 8 FT #HET 23 377 VAL A 1 701 0G2 A S 2 FT #HET 35 389 ALA A 1 701 0G2 A S 5 FT #HET 37 391 LYS A 1 701 0G2 A S 2 FT #HET 81 435 PHE A 1 701 0G2 A S 8 FT #HET 82 436 GLU A 1 701 0G2 A B 2 FT #HET 83 437 PHE A 1 701 0G2 A A 7 FT #HET 84 438 MET A 1 701 0G2 A A 11 FT #HET 85 439 GLU A 1 701 0G2 A B 3 FT #HET 86 440 HIS A 1 701 0G2 A B 2 FT #HET 87 441 GLY A 1 701 0G2 A B 6 FT #HET 135 489 LEU A 1 701 0G2 A S 9 FT #HET 145 499 SER A 1 701 0G2 A S 3 FT #HET 146 500 ASP A 1 701 0G2 A S 2 FT DISORDER 19 20 FT DISORDER 41 41 FT DISORDER 149 166 FT DISORDER 207 207 FT DISORDER 266 266 CC SEQUENCE 243 AA (ATOM); CC GSVIDPSELT FVQEIGSGGL VHLGYWLNKD KVAIKTIRGA MSEEDFIEEA EVMMKLSHPK CC LVQLYGVCLE QAPICLVFEF MEHGCLSDYL RTQRGLFAAE TLLGMCLDVC EGMAYLEEAC CC VIHRDLAARN CLVGENQVIK VSDFGPVKWA SPEVFSFSRY SSKSDVWSFG VLMWEVFSEG CC KIPYERSNSE VVEDISTGFR LYKPRLASTH VYQIMNHCWK ERPEDRPAFS RLLRQLAEIA CC ESG CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFI CC ATOM GSVIDPSELTFVQEIGSG--GLVHLGYWLNKDKVAIKTIR-GAMSEEDFI CC ****************** ******************** ********* CC SEQRES EEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLF CC ATOM EEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLF CC ************************************************** CC SEQRES AAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMT CC ATOM AAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFG-- CC ************************************************ CC SEQRES RFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSE CC ATOM ----------------PVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSE CC ********************************** CC SEQRES GKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPA CC ATOM GKIPYE-RSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPA CC ****** ******************************************* CC SEQRES FSRLLRQLAEIAESGL CC ATOM FSRLLRQLAEIAESG- CC *************** SQ SEQUENCE 266 AA; MW; CN; GSVIDPSELT FVQEIGSGQF GLVHLGYWLN KDKVAIKTIR EGAMSEEDFI EEAEVMMKLS HPKLVQLYGV CLEQAPICLV FEFMEHGCLS DYLRTQRGLF AAETLLGMCL DVCEGMAYLE EACVIHRDLA ARNCLVGENQ VIKVSDFGMT RFVLDDQYTS STGTKFPVKW ASPEVFSFSR YSSKSDVWSF GVLMWEVFSE GKIPYENRSN SEVVEDISTG FRLYKPRLAS THVYQIMNHC WKERPEDRPA FSRLLRQLAE IAESGL // ID 3V8WB STANDARD; PRT; 266 AA. DT CONVERTED FROM PDB (SEQRES) 3V8W DE Tyrosine-protein kinase ITK/TSK OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.270 CC R-Factor 0.252 FT #SUB 1 355 GLY B 121 475 GLU A Protein B 2 FT #SUB 2 356 SER B 118 472 TYR A Protein S 1 FT #SUB 2 356 SER B 121 475 GLU A Protein B 6 FT #SUB 8 362 GLU B 256 610 ARG A Protein S 11 FT #SUB 28 382 TRP B 114 468 GLU A Protein S 4 FT #SUB 28 382 TRP B 255 609 LEU A Protein S 2 FT #SUB 29 383 LEU B 255 609 LEU A Protein S 2 FT #SUB 29 383 LEU B 259 613 ALA A Protein S 1 FT #SUB 31 385 LYS B 107 461 GLY A Protein S 2 FT #SUB 31 385 LYS B 110 464 LEU A Protein S 1 FT #SUB 31 385 LYS B 111 465 ASP A Protein S 4 FT #SUB 31 385 LYS B 114 468 GLU A Protein S 1 FT #SUB 32 386 ASP B 63 417 LYS A Protein S 3 FT #SUB 32 386 ASP B 111 465 ASP A Protein S 1 FT #SUB 32 386 ASP B 114 468 GLU A Protein S 4 FT #SUB 56 410 MET B 60 414 SER A Protein B 2 FT #SUB 57 411 MET B 58 412 LYS A Protein B 1 FT #SUB 57 411 MET B 60 414 SER A Protein B 5 FT #SUB 57 411 MET B 118 472 TYR A Protein B 3 FT #SUB 58 412 LYS B 58 412 LYS A Protein B 5 FT #SUB 59 413 LEU B 60 414 SER A Protein B 3 FT #SUB 60 414 SER B 57 411 MET A Protein A 5 FT #SUB 60 414 SER B 59 413 LEU A Protein S 3 FT #SUB 60 414 SER B 60 414 SER A Protein A 6 FT #SUB 60 414 SER B 66 420 GLN A Protein S 3 FT #SUB 61 415 HIS B 66 420 GLN A Protein B 7 FT #SUB 62 416 PRO B 66 420 GLN A Protein A 5 FT #SUB 62 416 PRO B 67 421 LEU A Protein S 1 FT #SUB 62 416 PRO B 68 422 TYR A Protein S 6 FT #SUB 63 417 LYS B 32 386 ASP A Protein S 4 FT #SUB 63 417 LYS B 68 422 TYR A Protein S 3 FT #SUB 66 420 GLN B 60 414 SER A Protein S 2 FT #SUB 66 420 GLN B 61 415 HIS A Protein S 7 FT #SUB 66 420 GLN B 62 416 PRO A Protein S 5 FT #SUB 66 420 GLN B 66 420 GLN A Protein S 11 FT #SUB 67 421 LEU B 62 416 PRO A Protein B 1 FT #SUB 68 422 TYR B 62 416 PRO A Protein S 7 FT #SUB 68 422 TYR B 63 417 LYS A Protein S 2 FT #SUB 68 422 TYR B 114 468 GLU A Protein S 1 FT #SUB 107 461 GLY B 31 385 LYS A Protein B 3 FT #SUB 110 464 LEU B 31 385 LYS A Protein S 1 FT #SUB 111 465 ASP B 31 385 LYS A Protein S 4 FT #SUB 111 465 ASP B 32 386 ASP A Protein S 1 FT #SUB 114 468 GLU B 28 382 TRP A Protein S 4 FT #SUB 114 468 GLU B 31 385 LYS A Protein S 1 FT #SUB 114 468 GLU B 32 386 ASP A Protein S 4 FT #SUB 114 468 GLU B 68 422 TYR A Protein S 2 FT #SUB 118 472 TYR B 2 356 SER A Protein S 1 FT #SUB 118 472 TYR B 57 411 MET A Protein S 3 FT #SUB 121 475 GLU B 1 355 GLY A Protein S 2 FT #SUB 121 475 GLU B 2 356 SER A Protein S 6 FT #SUB 255 609 LEU B 28 382 TRP A Protein S 2 FT #SUB 255 609 LEU B 29 383 LEU A Protein S 2 FT #SUB 256 610 ARG B 8 362 GLU A Protein S 10 FT #SUB 259 613 ALA B 29 383 LEU A Protein S 1 FT #HET 15 369 ILE B 3 702 0G2 B A 7 FT #HET 23 377 VAL B 3 702 0G2 B S 1 FT #HET 35 389 ALA B 3 702 0G2 B S 5 FT #HET 37 391 LYS B 3 702 0G2 B S 2 FT #HET 81 435 PHE B 3 702 0G2 B S 8 FT #HET 82 436 GLU B 3 702 0G2 B B 2 FT #HET 83 437 PHE B 3 702 0G2 B A 10 FT #HET 84 438 MET B 3 702 0G2 B A 11 FT #HET 85 439 GLU B 3 702 0G2 B B 2 FT #HET 86 440 HIS B 3 702 0G2 B B 3 FT #HET 87 441 GLY B 3 702 0G2 B B 6 FT #HET 97 451 ARG B 2 701 SO4 B S 8 FT #HET 135 489 LEU B 3 702 0G2 B S 9 FT #HET 145 499 SER B 3 702 0G2 B S 3 FT #HET 146 500 ASP B 3 702 0G2 B S 3 FT #HET 201 555 GLY B 2 701 SO4 B B 1 FT #HET 202 556 LYS B 2 701 SO4 B S 5 FT #HET 206 560 GLU B 2 701 SO4 B S 1 FT DISORDER 19 20 FT DISORDER 41 43 FT DISORDER 149 166 FT DISORDER 266 266 CC SEQUENCE 242 AA (ATOM); CC GSVIDPSELT FVQEIGSGGL VHLGYWLNKD KVAIKTIRMS EEDFIEEAEV MMKLSHPKLV CC QLYGVCLEQA PICLVFEFME HGCLSDYLRT QRGLFAAETL LGMCLDVCEG MAYLEEACVI CC HRDLAARNCL VGENQVIKVS DFGPVKWASP EVFSFSRYSS KSDVWSFGVL MWEVFSEGKI CC PYENRSNSEV VEDISTGFRL YKPRLASTHV YQIMNHCWKE RPEDRPAFSR LLRQLAEIAE CC SG CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFI CC ATOM GSVIDPSELTFVQEIGSG--GLVHLGYWLNKDKVAIKTIR---MSEEDFI CC ****************** ******************** ******* CC SEQRES EEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLF CC ATOM EEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLF CC ************************************************** CC SEQRES AAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMT CC ATOM AAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFG-- CC ************************************************ CC SEQRES RFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSE CC ATOM ----------------PVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSE CC ********************************** CC SEQRES GKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPA CC ATOM GKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPA CC ************************************************** CC SEQRES FSRLLRQLAEIAESGL CC ATOM FSRLLRQLAEIAESG- CC *************** SQ SEQUENCE 266 AA; MW; CN; GSVIDPSELT FVQEIGSGQF GLVHLGYWLN KDKVAIKTIR EGAMSEEDFI EEAEVMMKLS HPKLVQLYGV CLEQAPICLV FEFMEHGCLS DYLRTQRGLF AAETLLGMCL DVCEGMAYLE EACVIHRDLA ARNCLVGENQ VIKVSDFGMT RFVLDDQYTS STGTKFPVKW ASPEVFSFSR YSSKSDVWSF GVLMWEVFSE GKIPYENRSN SEVVEDISTG FRLYKPRLAS THVYQIMNHC WKERPEDRPA FSRLLRQLAE IAESGL //