ID 3UUOA STANDARD; PRT; 337 AA. DT CONVERTED FROM PDB (SEQRES) 3UUO DE cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.110 CC R-Factor 0.197 FT #SUB 34 467 ARG A 324 757 ASP B Protein S 3 FT #SUB 34 467 ARG A 327 760 SER B Protein S 6 FT #SUB 34 467 ARG A 328 761 GLN B Protein S 1 FT #SUB 34 467 ARG A 331 764 LYS B Protein S 1 FT #SUB 38 471 GLU A 327 760 SER B Protein S 1 FT #SUB 38 471 GLU A 334 767 ARG B Protein S 1 FT #SUB 43 476 HIS A 334 767 ARG B Protein S 11 FT #SUB 48 481 PRO A 302 735 ILE B Protein A 2 FT #SUB 48 481 PRO A 323 756 ARG B Protein B 5 FT #SUB 48 481 PRO A 326 759 LEU B Protein S 2 FT #SUB 49 482 PHE A 323 756 ARG B Protein A 2 FT #SUB 51 484 ASN A 323 756 ARG B Protein S 3 FT #SUB 52 485 MET A 323 756 ARG B Protein S 1 FT #SUB 88 521 ARG A 217 650 GLN B Protein S 6 FT #SUB 248 681 LEU A 330 763 GLU B Protein S 1 FT #SUB 249 682 TRP A 291 724 GLN B Protein S 2 FT #SUB 250 683 PRO A 291 724 GLN B Protein S 4 FT #SUB 250 683 PRO A 295 728 GLY B Protein S 1 FT #SUB 251 684 VAL A 298 731 ASN B Protein S 1 FT #HET 91 524 TYR A 1 1 0CV A S 4 FT #HET 92 525 HIS A 1 1 0CV A S 1 FT #HET 92 525 HIS A 4 773 PO4 A S 9 FT #HET 96 529 HIS A 3 772 ZN A S 3 FT #HET 96 529 HIS A 4 773 PO4 A S 2 FT #HET 130 563 HIS A 3 772 ZN A S 3 FT #HET 131 564 ASP A 2 771 MG A S 3 FT #HET 131 564 ASP A 3 772 ZN A S 3 FT #HET 131 564 ASP A 4 773 PO4 A S 5 FT #HET 200 633 THR A 4 773 PO4 A B 1 FT #HET 202 635 LEU A 1 1 0CV A S 4 FT #HET 241 674 ASP A 3 772 ZN A S 3 FT #HET 241 674 ASP A 4 773 PO4 A S 6 FT #HET 242 675 LEU A 1 1 0CV A S 6 FT #HET 244 677 SER A 1 1 0CV A S 2 FT #HET 245 678 VAL A 1 1 0CV A S 1 FT #HET 259 692 ILE A 1 1 0CV A S 7 FT #HET 260 693 TYR A 1 1 0CV A S 4 FT #HET 263 696 PHE A 1 1 0CV A S 8 FT #HET 280 713 MET A 1 1 0CV A S 1 FT #HET 292 725 GLY A 1 1 0CV A B 7 FT #HET 293 726 GLN A 1 1 0CV A A 18 FT #HET 296 729 PHE A 1 1 0CV A S 27 FT DISORDER 1 31 FT DISORDER 337 337 CC SEQUENCE 305 AA (ATOM); CC PVRLCKEIEL FHFDIGPFEN MWPGIFVYMV HRSCGTSCFE LEKLCRFIMS VKKNYRRVPY CC HNWKHAVTVA HCMYAILQNN HTLFTDLERK GLLIACLCHD LDHRGFSNSY LQKFDHPLAA CC LYSTSTMEQH HFSQTVSILQ LEGHNIFSTL SSSEYEQVLE IIRKAIIATD LALYFGNRKQ CC LEEMYQTGSL NLNNQSHRDR VIGLMMTACD LCSVTKLWPV TKLTANDIYA EFWAEGDEMK CC KLGIQPIPMM DRDKKDEVPQ GQLGFYNAVA IPCYTTLTQI LPPTEPLLKA CRDNLSQWEK CC VIRGE CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSHMGMEKLSYHSHMSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFE CC ATOM -------------------------------PVRLCKEIELFHFDIGPFE CC ******************* CC SEQRES NMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTV CC ATOM NMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTV CC ************************************************** CC SEQRES AHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLA CC ATOM AHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLA CC ************************************************** CC SEQRES ALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIAT CC ATOM ALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIAT CC ************************************************** CC SEQRES DLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP CC ATOM DLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP CC ************************************************** CC SEQRES VTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAV CC ATOM VTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAV CC ************************************************** CC SEQRES AIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEE CC ATOM AIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGE- CC ************************************ SQ SEQUENCE 337 AA; MW; CN; GSHMGMEKLS YHSHMSICTS EEWQGLMQFT LPVRLCKEIE LFHFDIGPFE NMWPGIFVYM VHRSCGTSCF ELEKLCRFIM SVKKNYRRVP YHNWKHAVTV AHCMYAILQN NHTLFTDLER KGLLIACLCH DLDHRGFSNS YLQKFDHPLA ALYSTSTMEQ HHFSQTVSIL QLEGHNIFST LSSSEYEQVL EIIRKAIIAT DLALYFGNRK QLEEMYQTGS LNLNNQSHRD RVIGLMMTAC DLCSVTKLWP VTKLTANDIY AEFWAEGDEM KKLGIQPIPM MDRDKKDEVP QGQLGFYNAV AIPCYTTLTQ ILPPTEPLLK ACRDNLSQWE KVIRGEE // ID 3UUOB STANDARD; PRT; 337 AA. DT CONVERTED FROM PDB (SEQRES) 3UUO DE cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.110 CC R-Factor 0.197 FT #SUB 217 650 GLN B 88 521 ARG A Protein S 6 FT #SUB 291 724 GLN B 249 682 TRP A Protein S 2 FT #SUB 291 724 GLN B 250 683 PRO A Protein A 4 FT #SUB 295 728 GLY B 250 683 PRO A Protein B 1 FT #SUB 298 731 ASN B 251 684 VAL A Protein S 1 FT #SUB 302 735 ILE B 48 481 PRO A Protein S 2 FT #SUB 323 756 ARG B 48 481 PRO A Protein S 5 FT #SUB 323 756 ARG B 49 482 PHE A Protein S 2 FT #SUB 323 756 ARG B 51 484 ASN A Protein S 3 FT #SUB 323 756 ARG B 52 485 MET A Protein S 1 FT #SUB 324 757 ASP B 34 467 ARG A Protein A 3 FT #SUB 326 759 LEU B 48 481 PRO A Protein S 2 FT #SUB 327 760 SER B 34 467 ARG A Protein S 6 FT #SUB 327 760 SER B 38 471 GLU A Protein S 1 FT #SUB 328 761 GLN B 34 467 ARG A Protein S 1 FT #SUB 330 763 GLU B 248 681 LEU A Protein S 1 FT #SUB 331 764 LYS B 34 467 ARG A Protein S 1 FT #SUB 334 767 ARG B 38 471 GLU A Protein S 1 FT #SUB 334 767 ARG B 43 476 HIS A Protein S 11 FT #HET 91 524 TYR B 5 1 0CV B S 10 FT #HET 92 525 HIS B 5 1 0CV B S 2 FT #HET 92 525 HIS B 8 773 PO4 B S 9 FT #HET 96 529 HIS B 7 772 ZN B S 3 FT #HET 96 529 HIS B 8 773 PO4 B S 2 FT #HET 130 563 HIS B 7 772 ZN B S 3 FT #HET 131 564 ASP B 6 771 MG B S 3 FT #HET 131 564 ASP B 7 772 ZN B S 3 FT #HET 131 564 ASP B 8 773 PO4 B S 4 FT #HET 200 633 THR B 8 773 PO4 B B 1 FT #HET 202 635 LEU B 5 1 0CV B S 3 FT #HET 241 674 ASP B 7 772 ZN B S 3 FT #HET 241 674 ASP B 8 773 PO4 B S 6 FT #HET 242 675 LEU B 5 1 0CV B S 6 FT #HET 244 677 SER B 5 1 0CV B S 3 FT #HET 259 692 ILE B 5 1 0CV B S 7 FT #HET 260 693 TYR B 5 1 0CV B S 6 FT #HET 263 696 PHE B 5 1 0CV B S 7 FT #HET 280 713 MET B 5 1 0CV B S 6 FT #HET 292 725 GLY B 5 1 0CV B B 8 FT #HET 293 726 GLN B 5 1 0CV B A 16 FT #HET 296 729 PHE B 5 1 0CV B S 29 FT DISORDER 1 21 FT DISORDER 337 337 CC SEQUENCE 315 AA (ATOM); CC EWQGLMQFTL PVRLCKEIEL FHFDIGPFEN MWPGIFVYMV HRSCGTSCFE LEKLCRFIMS CC VKKNYRRVPY HNWKHAVTVA HCMYAILQNN HTLFTDLERK GLLIACLCHD LDHRGFSNSY CC LQKFDHPLAA LYSTSTMEQH HFSQTVSILQ LEGHNIFSTL SSSEYEQVLE IIRKAIIATD CC LALYFGNRKQ LEEMYQTGSL NLNNQSHRDR VIGLMMTACD LCSVTKLWPV TKLTANDIYA CC EFWAEGDEMK KLGIQPIPMM DRDKKDEVPQ GQLGFYNAVA IPCYTTLTQI LPPTEPLLKA CC CRDNLSQWEK VIRGE CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSHMGMEKLSYHSHMSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFE CC ATOM ---------------------EWQGLMQFTLPVRLCKEIELFHFDIGPFE CC ***************************** CC SEQRES NMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTV CC ATOM NMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTV CC ************************************************** CC SEQRES AHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLA CC ATOM AHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLA CC ************************************************** CC SEQRES ALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIAT CC ATOM ALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIAT CC ************************************************** CC SEQRES DLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP CC ATOM DLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP CC ************************************************** CC SEQRES VTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAV CC ATOM VTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAV CC ************************************************** CC SEQRES AIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEE CC ATOM AIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGE- CC ************************************ SQ SEQUENCE 337 AA; MW; CN; GSHMGMEKLS YHSHMSICTS EEWQGLMQFT LPVRLCKEIE LFHFDIGPFE NMWPGIFVYM VHRSCGTSCF ELEKLCRFIM SVKKNYRRVP YHNWKHAVTV AHCMYAILQN NHTLFTDLER KGLLIACLCH DLDHRGFSNS YLQKFDHPLA ALYSTSTMEQ HHFSQTVSIL QLEGHNIFST LSSSEYEQVL EIIRKAIIAT DLALYFGNRK QLEEMYQTGS LNLNNQSHRD RVIGLMMTAC DLCSVTKLWP VTKLTANDIY AEFWAEGDEM KKLGIQPIPM MDRDKKDEVP QGQLGFYNAV AIPCYTTLTQ ILPPTEPLLK ACRDNLSQWE KVIRGEE //