ID 3UI7A STANDARD; PRT; 333 AA. DT CONVERTED FROM PDB (SEQRES) 3UI7 DE cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.280 CC R-Factor 0.197 FT #SUB 30 467 ARG A 320 757 ASP B Protein S 2 FT #SUB 30 467 ARG A 323 760 SER B Protein S 1 FT #SUB 34 471 GLU A 327 764 LYS B Protein S 1 FT #SUB 34 471 GLU A 330 767 ARG B Protein S 1 FT #SUB 39 476 HIS A 330 767 ARG B Protein S 10 FT #SUB 41 478 ASP A 294 731 ASN B Protein S 1 FT #SUB 44 481 PRO A 294 731 ASN B Protein S 1 FT #SUB 44 481 PRO A 298 735 ILE B Protein A 3 FT #SUB 44 481 PRO A 319 756 ARG B Protein B 6 FT #SUB 44 481 PRO A 322 759 LEU B Protein S 2 FT #SUB 45 482 PHE A 319 756 ARG B Protein A 3 FT #SUB 47 484 ASN A 319 756 ARG B Protein S 1 FT #SUB 48 485 MET A 319 756 ARG B Protein S 2 FT #SUB 84 521 ARG A 210 647 GLU B Protein S 3 FT #SUB 84 521 ARG A 213 650 GLN B Protein S 4 FT #SUB 244 681 LEU A 290 727 LEU B Protein S 1 FT #SUB 244 681 LEU A 329 766 ILE B Protein S 1 FT #SUB 245 682 TRP A 287 724 GLN B Protein S 3 FT #SUB 246 683 PRO A 287 724 GLN B Protein S 4 FT #SUB 246 683 PRO A 291 728 GLY B Protein S 2 FT #SUB 332 769 GLU A 281 718 LYS B Protein B 1 FT #SUB 333 770 GLU A 275 712 PRO B Protein B 4 FT #HET 87 524 TYR A 1 1 C1L A S 2 FT #HET 88 525 HIS A 1 1 C1L A S 2 FT #HET 92 529 HIS A 3 772 ZN A S 3 FT #HET 126 563 HIS A 3 772 ZN A S 3 FT #HET 127 564 ASP A 2 771 MG A S 3 FT #HET 127 564 ASP A 3 772 ZN A S 3 FT #HET 155 592 GLU A 2 771 MG A S 1 FT #HET 158 595 HIS A 2 771 MG A S 1 FT #HET 237 674 ASP A 3 772 ZN A S 3 FT #HET 238 675 LEU A 1 1 C1L A A 3 FT #HET 240 677 SER A 1 1 C1L A S 1 FT #HET 241 678 VAL A 1 1 C1L A S 1 FT #HET 255 692 ILE A 1 1 C1L A S 4 FT #HET 256 693 TYR A 1 1 C1L A S 1 FT #HET 259 696 PHE A 1 1 C1L A S 3 FT #HET 276 713 MET A 1 1 C1L A S 5 FT #HET 289 726 GLN A 1 1 C1L A S 10 FT #HET 292 729 PHE A 1 1 C1L A S 22 FT DISORDER 1 18 CC SEQUENCE 315 AA (ATOM); CC WQGLMQFTLP VRLCKEIELF HFDIGPFENM WPGIFVYMVH RSCGTSCFEL EKLCRFIMSV CC KKNYRRVPYH NWKHAVTVAH CMYAILQNNH TLFTDLERKG LLIACLCHDL DHRGFSNSYL CC QKFDHPLAAL YSTSTMEQHH FSQTVSILQL EGHNIFSTLS SSEYEQVLEI IRKAIIATDL CC ALYFGNRKQL EEMYQTGSLN LNNQSHRDRV IGLMMTACDL CSVTKLWPVT KLTANDIYAE CC FWAEGDEMKK LGIQPIPMMD RDKKDEVPQG QLGFYNAVAI PCYTTLTQIL PPTEPLLKAC CC RDNLSQWEKV IRGEE CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GMEKLSYHSHMSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWP CC ATOM ------------------WQGLMQFTLPVRLCKEIELFHFDIGPFENMWP CC ******************************** CC SEQRES GIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCM CC ATOM GIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCM CC ************************************************** CC SEQRES YAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYS CC ATOM YAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYS CC ************************************************** CC SEQRES TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLAL CC ATOM TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLAL CC ************************************************** CC SEQRES YFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKL CC ATOM YFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKL CC ************************************************** CC SEQRES TANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPC CC ATOM TANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPC CC ************************************************** CC SEQRES YTTLTQILPPTEPLLKACRDNLSQWEKVIRGEE CC ATOM YTTLTQILPPTEPLLKACRDNLSQWEKVIRGEE CC ********************************* SQ SEQUENCE 333 AA; MW; CN; GMEKLSYHSH MSICTSEEWQ GLMQFTLPVR LCKEIELFHF DIGPFENMWP GIFVYMVHRS CGTSCFELEK LCRFIMSVKK NYRRVPYHNW KHAVTVAHCM YAILQNNHTL FTDLERKGLL IACLCHDLDH RGFSNSYLQK FDHPLAALYS TSTMEQHHFS QTVSILQLEG HNIFSTLSSS EYEQVLEIIR KAIIATDLAL YFGNRKQLEE MYQTGSLNLN NQSHRDRVIG LMMTACDLCS VTKLWPVTKL TANDIYAEFW AEGDEMKKLG IQPIPMMDRD KKDEVPQGQL GFYNAVAIPC YTTLTQILPP TEPLLKACRD NLSQWEKVIR GEE // ID 3UI7B STANDARD; PRT; 333 AA. DT CONVERTED FROM PDB (SEQRES) 3UI7 DE cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.280 CC R-Factor 0.197 FT #SUB 210 647 GLU B 84 521 ARG A Protein S 3 FT #SUB 213 650 GLN B 84 521 ARG A Protein S 4 FT #SUB 275 712 PRO B 333 770 GLU A Protein S 4 FT #SUB 281 718 LYS B 332 769 GLU A Protein S 1 FT #SUB 287 724 GLN B 245 682 TRP A Protein S 3 FT #SUB 287 724 GLN B 246 683 PRO A Protein A 4 FT #SUB 290 727 LEU B 244 681 LEU A Protein S 1 FT #SUB 291 728 GLY B 246 683 PRO A Protein B 2 FT #SUB 294 731 ASN B 41 478 ASP A Protein S 1 FT #SUB 294 731 ASN B 44 481 PRO A Protein S 1 FT #SUB 298 735 ILE B 44 481 PRO A Protein S 3 FT #SUB 319 756 ARG B 44 481 PRO A Protein S 6 FT #SUB 319 756 ARG B 45 482 PHE A Protein S 3 FT #SUB 319 756 ARG B 47 484 ASN A Protein S 1 FT #SUB 319 756 ARG B 48 485 MET A Protein S 2 FT #SUB 320 757 ASP B 30 467 ARG A Protein S 2 FT #SUB 322 759 LEU B 44 481 PRO A Protein S 2 FT #SUB 323 760 SER B 30 467 ARG A Protein S 1 FT #SUB 327 764 LYS B 34 471 GLU A Protein S 1 FT #SUB 329 766 ILE B 244 681 LEU A Protein S 1 FT #SUB 330 767 ARG B 34 471 GLU A Protein S 1 FT #SUB 330 767 ARG B 39 476 HIS A Protein S 10 FT #HET 87 524 TYR B 4 1 C1L B S 2 FT #HET 88 525 HIS B 4 1 C1L B S 3 FT #HET 92 529 HIS B 6 772 ZN B S 3 FT #HET 126 563 HIS B 6 772 ZN B S 3 FT #HET 127 564 ASP B 5 771 MG B S 3 FT #HET 127 564 ASP B 6 772 ZN B S 3 FT #HET 155 592 GLU B 5 771 MG B S 1 FT #HET 158 595 HIS B 5 771 MG B S 1 FT #HET 198 635 LEU B 4 1 C1L B S 1 FT #HET 237 674 ASP B 6 772 ZN B S 3 FT #HET 238 675 LEU B 4 1 C1L B S 2 FT #HET 241 678 VAL B 4 1 C1L B S 3 FT #HET 255 692 ILE B 4 1 C1L B S 6 FT #HET 256 693 TYR B 4 1 C1L B S 1 FT #HET 259 696 PHE B 4 1 C1L B S 8 FT #HET 276 713 MET B 4 1 C1L B S 2 FT #HET 288 725 GLY B 4 1 C1L B B 1 FT #HET 289 726 GLN B 4 1 C1L B S 11 FT #HET 292 729 PHE B 4 1 C1L B S 20 FT DISORDER 1 17 FT DISORDER 333 333 CC SEQUENCE 315 AA (ATOM); CC EWQGLMQFTL PVRLCKEIEL FHFDIGPFEN MWPGIFVYMV HRSCGTSCFE LEKLCRFIMS CC VKKNYRRVPY HNWKHAVTVA HCMYAILQNN HTLFTDLERK GLLIACLCHD LDHRGFSNSY CC LQKFDHPLAA LYSTSTMEQH HFSQTVSILQ LEGHNIFSTL SSSEYEQVLE IIRKAIIATD CC LALYFGNRKQ LEEMYQTGSL NLNNQSHRDR VIGLMMTACD LCSVTKLWPV TKLTANDIYA CC EFWAEGDEMK KLGIQPIPMM DRDKKDEVPQ GQLGFYNAVA IPCYTTLTQI LPPTEPLLKA CC CRDNLSQWEK VIRGE CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GMEKLSYHSHMSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWP CC ATOM -----------------EWQGLMQFTLPVRLCKEIELFHFDIGPFENMWP CC ********************************* CC SEQRES GIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCM CC ATOM GIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCM CC ************************************************** CC SEQRES YAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYS CC ATOM YAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYS CC ************************************************** CC SEQRES TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLAL CC ATOM TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLAL CC ************************************************** CC SEQRES YFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKL CC ATOM YFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKL CC ************************************************** CC SEQRES TANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPC CC ATOM TANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPC CC ************************************************** CC SEQRES YTTLTQILPPTEPLLKACRDNLSQWEKVIRGEE CC ATOM YTTLTQILPPTEPLLKACRDNLSQWEKVIRGE- CC ******************************** SQ SEQUENCE 333 AA; MW; CN; GMEKLSYHSH MSICTSEEWQ GLMQFTLPVR LCKEIELFHF DIGPFENMWP GIFVYMVHRS CGTSCFELEK LCRFIMSVKK NYRRVPYHNW KHAVTVAHCM YAILQNNHTL FTDLERKGLL IACLCHDLDH RGFSNSYLQK FDHPLAALYS TSTMEQHHFS QTVSILQLEG HNIFSTLSSS EYEQVLEIIR KAIIATDLAL YFGNRKQLEE MYQTGSLNLN NQSHRDRVIG LMMTACDLCS VTKLWPVTKL TANDIYAEFW AEGDEMKKLG IQPIPMMDRD KKDEVPQGQL GFYNAVAIPC YTTLTQILPP TEPLLKACRD NLSQWEKVIR GEE //