ID 3TFQA STANDARD; PRT; 286 AA. DT CONVERTED FROM PDB (SEQRES) 3TFQ DE Corticosteroid 11-beta-dehydrogenase isozyme 1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.800 CC R-Factor 0.166 FT #SUB 90 96 MET A 131 137 ARG B Protein S 1 FT #SUB 120 126 LEU A 283 289 PHE B Protein B 2 FT #SUB 121 127 ASN A 194 200 GLU B Protein B 1 FT #SUB 121 127 ASN A 283 289 PHE B Protein A 2 FT #SUB 122 128 LEU A 194 200 GLU B Protein A 6 FT #SUB 122 128 LEU A 283 289 PHE B Protein S 3 FT #SUB 123 129 PHE A 142 148 VAL B Protein S 1 FT #SUB 123 129 PHE A 146 152 VAL B Protein S 2 FT #SUB 123 129 PHE A 187 193 PHE B Protein S 6 FT #SUB 123 129 PHE A 191 197 ILE B Protein S 1 FT #SUB 123 129 PHE A 194 200 GLU B Protein A 5 FT #SUB 124 130 HIS A 146 152 VAL B Protein B 2 FT #SUB 125 131 ASP A 146 152 VAL B Protein S 1 FT #SUB 127 133 ILE A 142 148 VAL B Protein S 2 FT #SUB 127 133 ILE A 143 149 VAL B Protein S 2 FT #SUB 130 136 VAL A 138 144 PHE B Protein S 2 FT #SUB 130 136 VAL A 139 145 LEU B Protein S 1 FT #SUB 130 136 VAL A 187 193 PHE B Protein S 1 FT #SUB 131 137 ARG A 90 96 MET B Protein S 3 FT #SUB 131 137 ARG A 135 141 GLU B Protein S 10 FT #SUB 131 137 ARG A 139 145 LEU B Protein A 4 FT #SUB 134 140 MET A 134 140 MET B Protein S 1 FT #SUB 134 140 MET A 138 144 PHE B Protein S 2 FT #SUB 135 141 GLU A 131 137 ARG B Protein S 6 FT #SUB 138 144 PHE A 130 136 VAL B Protein S 2 FT #SUB 138 144 PHE A 134 140 MET B Protein S 2 FT #SUB 138 144 PHE A 179 185 ALA B Protein S 2 FT #SUB 139 145 LEU A 127 133 ILE B Protein S 2 FT #SUB 139 145 LEU A 130 136 VAL B Protein S 1 FT #SUB 139 145 LEU A 131 137 ARG B Protein S 5 FT #SUB 142 148 VAL A 123 129 PHE B Protein S 1 FT #SUB 142 148 VAL A 127 133 ILE B Protein S 3 FT #SUB 143 149 VAL A 127 133 ILE B Protein S 2 FT #SUB 146 152 VAL A 123 129 PHE B Protein S 2 FT #SUB 146 152 VAL A 124 130 HIS B Protein S 2 FT #SUB 146 152 VAL A 125 131 ASP B Protein S 1 FT #SUB 165 171 LEU A 274 280 TYR B Protein S 2 FT #SUB 168 174 LYS A 267 273 ARG B Protein B 1 FT #SUB 169 175 VAL A 267 273 ARG B Protein S 1 FT #SUB 169 175 VAL A 271 277 GLU B Protein A 4 FT #SUB 169 175 VAL A 274 280 TYR B Protein S 1 FT #SUB 170 176 ALA A 189 195 SER B Protein S 3 FT #SUB 170 176 ALA A 193 199 LYS B Protein A 4 FT #SUB 170 176 ALA A 271 277 GLU B Protein A 5 FT #SUB 171 177 TYR A 190 196 SER B Protein B 4 FT #SUB 171 177 TYR A 274 280 TYR B Protein S 9 FT #SUB 172 178 PRO A 190 196 SER B Protein B 2 FT #SUB 172 178 PRO A 193 199 LYS B Protein S 1 FT #SUB 172 178 PRO A 194 200 GLU B Protein A 3 FT #SUB 172 178 PRO A 278 284 TYR B Protein S 6 FT #SUB 172 178 PRO A 280 286 MET B Protein S 2 FT #SUB 173 179 MET A 194 200 GLU B Protein B 5 FT #SUB 173 179 MET A 280 286 MET B Protein S 5 FT #SUB 173 179 MET A 283 289 PHE B Protein S 2 FT #SUB 175 181 ALA A 187 193 PHE B Protein A 5 FT #SUB 175 181 ALA A 190 196 SER B Protein A 5 FT #SUB 175 181 ALA A 191 197 ILE B Protein S 1 FT #SUB 178 184 SER A 186 192 GLY B Protein S 3 FT #SUB 179 185 ALA A 138 144 PHE B Protein S 1 FT #SUB 179 185 ALA A 183 189 ALA B Protein A 4 FT #SUB 179 185 ALA A 187 193 PHE B Protein S 1 FT #SUB 182 188 PHE A 182 188 PHE B Protein A 8 FT #SUB 182 188 PHE A 185 191 ASP B Protein S 2 FT #SUB 182 188 PHE A 186 192 GLY B Protein S 5 FT #SUB 182 188 PHE A 267 273 ARG B Protein S 1 FT #SUB 183 189 ALA A 179 185 ALA B Protein A 4 FT #SUB 185 191 ASP A 182 188 PHE B Protein S 2 FT #SUB 186 192 GLY A 178 184 SER B Protein B 3 FT #SUB 186 192 GLY A 182 188 PHE B Protein B 5 FT #SUB 187 193 PHE A 123 129 PHE B Protein S 6 FT #SUB 187 193 PHE A 130 136 VAL B Protein S 1 FT #SUB 187 193 PHE A 175 181 ALA B Protein A 5 FT #SUB 187 193 PHE A 179 185 ALA B Protein S 1 FT #SUB 189 195 SER A 170 176 ALA B Protein A 3 FT #SUB 190 196 SER A 171 177 TYR B Protein A 4 FT #SUB 190 196 SER A 172 178 PRO B Protein A 2 FT #SUB 190 196 SER A 174 180 VAL B Protein S 1 FT #SUB 190 196 SER A 175 181 ALA B Protein S 5 FT #SUB 191 197 ILE A 123 129 PHE B Protein S 1 FT #SUB 191 197 ILE A 175 181 ALA B Protein S 1 FT #SUB 193 199 LYS A 170 176 ALA B Protein S 4 FT #SUB 194 200 GLU A 121 127 ASN B Protein S 1 FT #SUB 194 200 GLU A 122 128 LEU B Protein S 8 FT #SUB 194 200 GLU A 123 129 PHE B Protein S 5 FT #SUB 194 200 GLU A 172 178 PRO B Protein S 3 FT #SUB 194 200 GLU A 173 179 MET B Protein S 5 FT #SUB 222 228 SER A 282 288 ARG B Protein B 2 FT #SUB 223 229 GLY A 279 285 ASN B Protein B 1 FT #SUB 223 229 GLY A 282 288 ARG B Protein B 2 FT #SUB 224 230 ILE A 278 284 TYR B Protein B 3 FT #SUB 224 230 ILE A 279 285 ASN B Protein A 7 FT #SUB 224 230 ILE A 282 288 ARG B Protein S 6 FT #SUB 225 231 VAL A 277 283 SER B Protein A 3 FT #SUB 226 232 HIS A 277 283 SER B Protein A 2 FT #SUB 226 232 HIS A 279 285 ASN B Protein S 1 FT #SUB 227 233 MET A 277 283 SER B Protein S 4 FT #SUB 258 264 THR A 270 276 LEU B Protein B 1 FT #SUB 258 264 THR A 274 280 TYR B Protein S 5 FT #SUB 261 267 LEU A 266 272 CYS B Protein B 1 FT #SUB 261 267 LEU A 269 275 ILE B Protein S 1 FT #SUB 261 267 LEU A 270 276 LEU B Protein S 3 FT #SUB 261 267 LEU A 273 279 LEU B Protein S 1 FT #SUB 262 268 ILE A 270 276 LEU B Protein S 1 FT #SUB 264 270 ASN A 264 270 ASN B Protein S 3 FT #SUB 266 272 CYS A 261 267 LEU B Protein S 2 FT #SUB 267 273 ARG A 168 174 LYS B Protein S 1 FT #SUB 267 273 ARG A 169 175 VAL B Protein S 2 FT #SUB 267 273 ARG A 182 188 PHE B Protein S 1 FT #SUB 269 275 ILE A 261 267 LEU B Protein S 1 FT #SUB 270 276 LEU A 258 264 THR B Protein S 1 FT #SUB 270 276 LEU A 261 267 LEU B Protein S 2 FT #SUB 270 276 LEU A 262 268 ILE B Protein S 1 FT #SUB 271 277 GLU A 169 175 VAL B Protein S 4 FT #SUB 271 277 GLU A 170 176 ALA B Protein S 8 FT #SUB 273 279 LEU A 261 267 LEU B Protein S 1 FT #SUB 274 280 TYR A 165 171 LEU B Protein S 2 FT #SUB 274 280 TYR A 171 177 TYR B Protein S 6 FT #SUB 274 280 TYR A 258 264 THR B Protein S 5 FT #SUB 277 283 SER A 224 230 ILE B Protein B 1 FT #SUB 277 283 SER A 225 231 VAL B Protein B 2 FT #SUB 277 283 SER A 226 232 HIS B Protein A 7 FT #SUB 277 283 SER A 227 233 MET B Protein S 2 FT #SUB 278 284 TYR A 171 177 TYR B Protein S 3 FT #SUB 278 284 TYR A 172 178 PRO B Protein S 2 FT #SUB 278 284 TYR A 173 179 MET B Protein S 2 FT #SUB 278 284 TYR A 224 230 ILE B Protein B 2 FT #SUB 278 284 TYR A 225 231 VAL B Protein S 1 FT #SUB 278 284 TYR A 227 233 MET B Protein S 1 FT #SUB 279 285 ASN A 223 229 GLY B Protein S 3 FT #SUB 279 285 ASN A 224 230 ILE B Protein A 7 FT #SUB 279 285 ASN A 226 232 HIS B Protein S 1 FT #SUB 280 286 MET A 172 178 PRO B Protein S 3 FT #SUB 280 286 MET A 173 179 MET B Protein S 2 FT #SUB 20 26 GLU A 15 21 ARG D Protein S 4 FT #SUB 257 263 TRP A 272 278 GLU D Protein S 2 FT #SUB 257 263 TRP A 276 282 THR D Protein S 2 FT #SUB 260 266 LEU A 269 275 ILE D Protein B 2 FT #SUB 260 266 LEU A 272 278 GLU D Protein S 2 FT #SUB 261 267 LEU A 269 275 ILE D Protein S 1 FT #SUB 265 271 PRO A 265 271 PRO D Protein S 3 FT #SUB 269 275 ILE A 260 266 LEU D Protein S 2 FT #SUB 269 275 ILE A 261 267 LEU D Protein S 1 FT #SUB 272 278 GLU A 257 263 TRP D Protein A 3 FT #SUB 272 278 GLU A 260 266 LEU D Protein S 5 FT #SUB 273 279 LEU A 257 263 TRP D Protein S 1 FT #SUB 276 282 THR A 257 263 TRP D Protein S 2 FT #SUB 269 275 ILE A 266 272 CYS E Protein S 1 FT #HET 35 41 GLY A 1 301 NAP A B 8 FT #HET 36 42 ALA A 1 301 NAP A B 1 FT #HET 37 43 SER A 1 301 NAP A A 9 FT #HET 38 44 LYS A 1 301 NAP A A 6 FT #HET 39 45 GLY A 1 301 NAP A B 4 FT #HET 40 46 ILE A 1 301 NAP A A 8 FT #HET 59 65 ALA A 1 301 NAP A A 6 FT #HET 60 66 ARG A 1 301 NAP A A 29 FT #HET 61 67 SER A 1 301 NAP A A 5 FT #HET 85 91 GLY A 1 301 NAP A B 1 FT #HET 86 92 THR A 1 301 NAP A A 5 FT #HET 87 93 MET A 1 301 NAP A A 9 FT #HET 88 94 GLU A 1 301 NAP A S 2 FT #HET 113 119 ASN A 1 301 NAP A A 11 FT #HET 114 120 HIS A 1 301 NAP A A 3 FT #HET 115 121 ILE A 1 301 NAP A A 12 FT #HET 115 121 ILE A 2 302 07M A S 2 FT #HET 118 124 THR A 2 302 07M A A 6 FT #HET 119 125 SER A 2 302 07M A B 3 FT #HET 120 126 LEU A 2 302 07M A S 2 FT #HET 141 147 TYR A 1 301 NAP A S 1 FT #HET 162 168 VAL A 1 301 NAP A A 5 FT #HET 163 169 SER A 1 301 NAP A B 3 FT #HET 164 170 SER A 1 301 NAP A S 3 FT #HET 164 170 SER A 2 302 07M A S 6 FT #HET 165 171 LEU A 2 302 07M A A 3 FT #HET 174 180 VAL A 2 302 07M A S 1 FT #HET 177 183 TYR A 1 301 NAP A S 7 FT #HET 177 183 TYR A 2 302 07M A S 14 FT #HET 181 187 LYS A 1 301 NAP A S 5 FT #HET 209 215 LEU A 1 301 NAP A A 5 FT #HET 209 215 LEU A 2 302 07M A B 1 FT #HET 210 216 GLY A 1 301 NAP A B 4 FT #HET 210 216 GLY A 2 302 07M A B 2 FT #HET 211 217 LEU A 1 301 NAP A A 3 FT #HET 211 217 LEU A 2 302 07M A B 1 FT #HET 212 218 ILE A 1 301 NAP A A 11 FT #HET 214 220 THR A 1 301 NAP A S 8 FT #HET 216 222 THR A 1 301 NAP A S 5 FT #HET 216 222 THR A 2 302 07M A S 2 FT #HET 217 223 ALA A 1 301 NAP A S 3 FT #HET 217 223 ALA A 2 302 07M A B 2 FT #HET 220 226 ALA A 2 302 07M A S 2 FT #HET 221 227 VAL A 2 302 07M A S 1 FT #HET 225 231 VAL A 2 302 07M A S 2 FT #HET 227 233 MET A 2 302 07M A S 2 FT DISORDER 1 19 FT DISORDER 282 286 CC SEQUENCE 262 AA (ATOM); CC EFRPEMLQGK KVIVTGASKG IGREMAYHLA KMGAHVVVTA RSKETLQKVV SHCLELGAAS CC AHYIAGTMED MTFAEQFVAQ AGKLMGGLDM LILNHITNTS LNLFHDDIHH VRKSMEVNFL CC SYVVLTVAAL PMLKQSNGSI VVVSSLAGKV AYPMVAAYSA SKFALDGFFS SIRKEYSVSR CC VNVSITLCVL GLIDTETAMK AVSGIVHMQA APKEECALEI IKGGALRQEE VYYDSSRWTT CC LLIRNPCRKI LEELYSTSYN MD CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSHMASMTGGQQMGRGSNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAK CC ATOM -------------------EFRPEMLQGKKVIVTGASKGIGREMAYHLAK CC ******************************* CC SEQRES MGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQA CC ATOM MGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQA CC ************************************************** CC SEQRES GKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP CC ATOM GKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP CC ************************************************** CC SEQRES MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRV CC ATOM MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRV CC ************************************************** CC SEQRES NVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEV CC ATOM NVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEV CC ************************************************** CC SEQRES YYDSSRWTTLLIRNPCRKILEELYSTSYNMDRFINK CC ATOM YYDSSRWTTLLIRNPCRKILEELYSTSYNMD----- CC ******************************* SQ SEQUENCE 286 AA; MW; CN; GSHMASMTGG QQMGRGSNEE FRPEMLQGKK VIVTGASKGI GREMAYHLAK MGAHVVVTAR SKETLQKVVS HCLELGAASA HYIAGTMEDM TFAEQFVAQA GKLMGGLDML ILNHITNTSL NLFHDDIHHV RKSMEVNFLS YVVLTVAALP MLKQSNGSIV VVSSLAGKVA YPMVAAYSAS KFALDGFFSS IRKEYSVSRV NVSITLCVLG LIDTETAMKA VSGIVHMQAA PKEECALEII KGGALRQEEV YYDSSRWTTL LIRNPCRKIL EELYSTSYNM DRFINK // ID 3TFQB STANDARD; PRT; 286 AA. DT CONVERTED FROM PDB (SEQRES) 3TFQ DE Corticosteroid 11-beta-dehydrogenase isozyme 1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.800 CC R-Factor 0.166 FT #SUB 90 96 MET B 131 137 ARG A Protein S 3 FT #SUB 121 127 ASN B 194 200 GLU A Protein B 1 FT #SUB 122 128 LEU B 194 200 GLU A Protein A 8 FT #SUB 123 129 PHE B 142 148 VAL A Protein S 1 FT #SUB 123 129 PHE B 146 152 VAL A Protein S 2 FT #SUB 123 129 PHE B 187 193 PHE A Protein S 6 FT #SUB 123 129 PHE B 191 197 ILE A Protein S 1 FT #SUB 123 129 PHE B 194 200 GLU A Protein A 5 FT #SUB 124 130 HIS B 146 152 VAL A Protein B 2 FT #SUB 125 131 ASP B 146 152 VAL A Protein S 1 FT #SUB 127 133 ILE B 139 145 LEU A Protein S 2 FT #SUB 127 133 ILE B 142 148 VAL A Protein S 3 FT #SUB 127 133 ILE B 143 149 VAL A Protein S 2 FT #SUB 130 136 VAL B 138 144 PHE A Protein S 2 FT #SUB 130 136 VAL B 139 145 LEU A Protein S 1 FT #SUB 130 136 VAL B 187 193 PHE A Protein S 1 FT #SUB 131 137 ARG B 90 96 MET A Protein S 1 FT #SUB 131 137 ARG B 135 141 GLU A Protein S 6 FT #SUB 131 137 ARG B 139 145 LEU A Protein A 5 FT #SUB 134 140 MET B 134 140 MET A Protein S 1 FT #SUB 134 140 MET B 138 144 PHE A Protein S 2 FT #SUB 135 141 GLU B 131 137 ARG A Protein S 10 FT #SUB 138 144 PHE B 130 136 VAL A Protein S 2 FT #SUB 138 144 PHE B 134 140 MET A Protein S 2 FT #SUB 138 144 PHE B 179 185 ALA A Protein S 1 FT #SUB 139 145 LEU B 130 136 VAL A Protein S 1 FT #SUB 139 145 LEU B 131 137 ARG A Protein S 4 FT #SUB 142 148 VAL B 123 129 PHE A Protein S 1 FT #SUB 142 148 VAL B 127 133 ILE A Protein S 2 FT #SUB 143 149 VAL B 127 133 ILE A Protein S 2 FT #SUB 146 152 VAL B 123 129 PHE A Protein S 2 FT #SUB 146 152 VAL B 124 130 HIS A Protein S 2 FT #SUB 146 152 VAL B 125 131 ASP A Protein S 1 FT #SUB 165 171 LEU B 274 280 TYR A Protein S 2 FT #SUB 168 174 LYS B 267 273 ARG A Protein B 1 FT #SUB 169 175 VAL B 267 273 ARG A Protein A 2 FT #SUB 169 175 VAL B 271 277 GLU A Protein A 4 FT #SUB 170 176 ALA B 189 195 SER A Protein S 3 FT #SUB 170 176 ALA B 193 199 LYS A Protein A 4 FT #SUB 170 176 ALA B 271 277 GLU A Protein A 8 FT #SUB 171 177 TYR B 190 196 SER A Protein B 4 FT #SUB 171 177 TYR B 274 280 TYR A Protein S 6 FT #SUB 171 177 TYR B 278 284 TYR A Protein S 3 FT #SUB 172 178 PRO B 190 196 SER A Protein B 2 FT #SUB 172 178 PRO B 194 200 GLU A Protein A 3 FT #SUB 172 178 PRO B 278 284 TYR A Protein S 2 FT #SUB 172 178 PRO B 280 286 MET A Protein S 3 FT #SUB 173 179 MET B 194 200 GLU A Protein B 5 FT #SUB 173 179 MET B 278 284 TYR A Protein S 2 FT #SUB 173 179 MET B 280 286 MET A Protein S 2 FT #SUB 174 180 VAL B 190 196 SER A Protein B 1 FT #SUB 175 181 ALA B 187 193 PHE A Protein A 5 FT #SUB 175 181 ALA B 190 196 SER A Protein A 5 FT #SUB 175 181 ALA B 191 197 ILE A Protein S 1 FT #SUB 178 184 SER B 186 192 GLY A Protein S 3 FT #SUB 179 185 ALA B 138 144 PHE A Protein S 2 FT #SUB 179 185 ALA B 183 189 ALA A Protein A 4 FT #SUB 179 185 ALA B 187 193 PHE A Protein S 1 FT #SUB 182 188 PHE B 182 188 PHE A Protein A 8 FT #SUB 182 188 PHE B 185 191 ASP A Protein S 2 FT #SUB 182 188 PHE B 186 192 GLY A Protein S 5 FT #SUB 182 188 PHE B 267 273 ARG A Protein S 1 FT #SUB 183 189 ALA B 179 185 ALA A Protein A 4 FT #SUB 185 191 ASP B 182 188 PHE A Protein S 2 FT #SUB 186 192 GLY B 178 184 SER A Protein B 3 FT #SUB 186 192 GLY B 182 188 PHE A Protein B 5 FT #SUB 187 193 PHE B 123 129 PHE A Protein S 6 FT #SUB 187 193 PHE B 130 136 VAL A Protein S 1 FT #SUB 187 193 PHE B 175 181 ALA A Protein A 5 FT #SUB 187 193 PHE B 179 185 ALA A Protein S 1 FT #SUB 189 195 SER B 170 176 ALA A Protein A 3 FT #SUB 190 196 SER B 171 177 TYR A Protein A 4 FT #SUB 190 196 SER B 172 178 PRO A Protein A 2 FT #SUB 190 196 SER B 175 181 ALA A Protein S 5 FT #SUB 191 197 ILE B 123 129 PHE A Protein S 1 FT #SUB 191 197 ILE B 175 181 ALA A Protein S 1 FT #SUB 193 199 LYS B 170 176 ALA A Protein S 4 FT #SUB 193 199 LYS B 172 178 PRO A Protein S 1 FT #SUB 194 200 GLU B 121 127 ASN A Protein S 1 FT #SUB 194 200 GLU B 122 128 LEU A Protein S 6 FT #SUB 194 200 GLU B 123 129 PHE A Protein S 5 FT #SUB 194 200 GLU B 172 178 PRO A Protein S 3 FT #SUB 194 200 GLU B 173 179 MET A Protein S 5 FT #SUB 223 229 GLY B 279 285 ASN A Protein B 3 FT #SUB 224 230 ILE B 277 283 SER A Protein B 1 FT #SUB 224 230 ILE B 278 284 TYR A Protein B 2 FT #SUB 224 230 ILE B 279 285 ASN A Protein A 7 FT #SUB 225 231 VAL B 277 283 SER A Protein B 2 FT #SUB 225 231 VAL B 278 284 TYR A Protein S 1 FT #SUB 226 232 HIS B 277 283 SER A Protein A 7 FT #SUB 226 232 HIS B 279 285 ASN A Protein S 1 FT #SUB 227 233 MET B 277 283 SER A Protein S 2 FT #SUB 227 233 MET B 278 284 TYR A Protein S 1 FT #SUB 258 264 THR B 270 276 LEU A Protein B 1 FT #SUB 258 264 THR B 274 280 TYR A Protein S 5 FT #SUB 261 267 LEU B 266 272 CYS A Protein A 2 FT #SUB 261 267 LEU B 269 275 ILE A Protein S 1 FT #SUB 261 267 LEU B 270 276 LEU A Protein S 2 FT #SUB 261 267 LEU B 273 279 LEU A Protein S 1 FT #SUB 262 268 ILE B 270 276 LEU A Protein S 1 FT #SUB 264 270 ASN B 264 270 ASN A Protein S 3 FT #SUB 266 272 CYS B 261 267 LEU A Protein S 1 FT #SUB 267 273 ARG B 168 174 LYS A Protein S 1 FT #SUB 267 273 ARG B 169 175 VAL A Protein S 1 FT #SUB 267 273 ARG B 182 188 PHE A Protein S 1 FT #SUB 269 275 ILE B 261 267 LEU A Protein S 1 FT #SUB 270 276 LEU B 258 264 THR A Protein S 1 FT #SUB 270 276 LEU B 261 267 LEU A Protein S 3 FT #SUB 270 276 LEU B 262 268 ILE A Protein S 1 FT #SUB 271 277 GLU B 169 175 VAL A Protein S 4 FT #SUB 271 277 GLU B 170 176 ALA A Protein S 5 FT #SUB 273 279 LEU B 261 267 LEU A Protein S 1 FT #SUB 274 280 TYR B 165 171 LEU A Protein S 2 FT #SUB 274 280 TYR B 169 175 VAL A Protein S 1 FT #SUB 274 280 TYR B 171 177 TYR A Protein S 9 FT #SUB 274 280 TYR B 258 264 THR A Protein S 5 FT #SUB 277 283 SER B 225 231 VAL A Protein B 3 FT #SUB 277 283 SER B 226 232 HIS A Protein B 2 FT #SUB 277 283 SER B 227 233 MET A Protein S 4 FT #SUB 278 284 TYR B 172 178 PRO A Protein S 6 FT #SUB 278 284 TYR B 224 230 ILE A Protein A 3 FT #SUB 279 285 ASN B 223 229 GLY A Protein S 1 FT #SUB 279 285 ASN B 224 230 ILE A Protein A 7 FT #SUB 279 285 ASN B 226 232 HIS A Protein S 1 FT #SUB 280 286 MET B 172 178 PRO A Protein S 2 FT #SUB 280 286 MET B 173 179 MET A Protein S 5 FT #SUB 282 288 ARG B 222 228 SER A Protein S 2 FT #SUB 282 288 ARG B 223 229 GLY A Protein S 2 FT #SUB 282 288 ARG B 224 230 ILE A Protein S 6 FT #SUB 283 289 PHE B 120 126 LEU A Protein S 2 FT #SUB 283 289 PHE B 121 127 ASN A Protein S 2 FT #SUB 283 289 PHE B 122 128 LEU A Protein A 3 FT #SUB 283 289 PHE B 173 179 MET A Protein S 2 FT #SUB 266 272 CYS B 269 275 ILE D Protein S 1 FT #SUB 256 262 ARG B 272 278 GLU E Protein S 1 FT #SUB 257 263 TRP B 269 275 ILE E Protein S 5 FT #SUB 257 263 TRP B 273 279 LEU E Protein S 2 FT #SUB 260 266 LEU B 265 271 PRO E Protein A 3 FT #SUB 261 267 LEU B 269 275 ILE E Protein S 2 FT #SUB 265 271 PRO B 260 266 LEU E Protein S 3 FT #SUB 268 274 LYS B 260 266 LEU E Protein S 1 FT #SUB 269 275 ILE B 257 263 TRP E Protein S 4 FT #SUB 269 275 ILE B 261 267 LEU E Protein S 2 FT #SUB 272 278 GLU B 256 262 ARG E Protein S 4 FT #SUB 272 278 GLU B 257 263 TRP E Protein S 6 FT #SUB 273 279 LEU B 257 263 TRP E Protein S 2 FT #HET 35 41 GLY B 3 301 NAP B B 8 FT #HET 36 42 ALA B 3 301 NAP B B 1 FT #HET 37 43 SER B 3 301 NAP B A 9 FT #HET 38 44 LYS B 3 301 NAP B A 7 FT #HET 39 45 GLY B 3 301 NAP B B 4 FT #HET 40 46 ILE B 3 301 NAP B A 7 FT #HET 59 65 ALA B 3 301 NAP B A 7 FT #HET 60 66 ARG B 3 301 NAP B A 27 FT #HET 61 67 SER B 3 301 NAP B A 3 FT #HET 85 91 GLY B 3 301 NAP B B 1 FT #HET 86 92 THR B 3 301 NAP B A 5 FT #HET 87 93 MET B 3 301 NAP B A 9 FT #HET 88 94 GLU B 3 301 NAP B S 2 FT #HET 113 119 ASN B 3 301 NAP B A 11 FT #HET 114 120 HIS B 3 301 NAP B A 3 FT #HET 115 121 ILE B 3 301 NAP B A 11 FT #HET 115 121 ILE B 4 302 07M B S 2 FT #HET 118 124 THR B 4 302 07M B A 6 FT #HET 119 125 SER B 4 302 07M B B 3 FT #HET 120 126 LEU B 4 302 07M B S 2 FT #HET 162 168 VAL B 3 301 NAP B A 6 FT #HET 163 169 SER B 3 301 NAP B B 4 FT #HET 164 170 SER B 3 301 NAP B S 3 FT #HET 164 170 SER B 4 302 07M B S 6 FT #HET 165 171 LEU B 4 302 07M B A 4 FT #HET 171 177 TYR B 4 302 07M B S 2 FT #HET 174 180 VAL B 4 302 07M B S 1 FT #HET 177 183 TYR B 3 301 NAP B S 7 FT #HET 177 183 TYR B 4 302 07M B S 13 FT #HET 181 187 LYS B 3 301 NAP B S 4 FT #HET 209 215 LEU B 3 301 NAP B A 5 FT #HET 209 215 LEU B 4 302 07M B B 1 FT #HET 210 216 GLY B 3 301 NAP B B 3 FT #HET 210 216 GLY B 4 302 07M B B 2 FT #HET 211 217 LEU B 3 301 NAP B A 3 FT #HET 211 217 LEU B 4 302 07M B B 1 FT #HET 212 218 ILE B 3 301 NAP B A 11 FT #HET 214 220 THR B 3 301 NAP B S 8 FT #HET 216 222 THR B 3 301 NAP B S 5 FT #HET 216 222 THR B 4 302 07M B S 2 FT #HET 217 223 ALA B 3 301 NAP B S 3 FT #HET 217 223 ALA B 4 302 07M B A 5 FT #HET 220 226 ALA B 4 302 07M B S 2 FT #HET 225 231 VAL B 4 302 07M B S 2 FT DISORDER 1 3 FT DISORDER 285 286 CC SEQUENCE 281 AA (ATOM); CC MASMTGGQQM GRGSNEEFRP EMLQGKKVIV TGASKGIGRE MAYHLAKMGA HVVVTARSKE CC TLQKVVSHCL ELGAASAHYI AGTMEDMTFA EQFVAQAGKL MGGLDMLILN HITNTSLNLF CC HDDIHHVRKS MEVNFLSYVV LTVAALPMLK QSNGSIVVVS SLAGKVAYPM VAAYSASKFA CC LDGFFSSIRK EYSVSRVNVS ITLCVLGLID TETAMKAVSG IVHMQAAPKE ECALEIIKGG CC ALRQEEVYYD SSRWTTLLIR NPCRKILEEL YSTSYNMDRF I CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSHMASMTGGQQMGRGSNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAK CC ATOM ---MASMTGGQQMGRGSNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAK CC *********************************************** CC SEQRES MGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQA CC ATOM MGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQA CC ************************************************** CC SEQRES GKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP CC ATOM GKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP CC ************************************************** CC SEQRES MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRV CC ATOM MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRV CC ************************************************** CC SEQRES NVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEV CC ATOM NVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEV CC ************************************************** CC SEQRES YYDSSRWTTLLIRNPCRKILEELYSTSYNMDRFINK CC ATOM YYDSSRWTTLLIRNPCRKILEELYSTSYNMDRFI-- CC ********************************** SQ SEQUENCE 286 AA; MW; CN; GSHMASMTGG QQMGRGSNEE FRPEMLQGKK VIVTGASKGI GREMAYHLAK MGAHVVVTAR SKETLQKVVS HCLELGAASA HYIAGTMEDM TFAEQFVAQA GKLMGGLDML ILNHITNTSL NLFHDDIHHV RKSMEVNFLS YVVLTVAALP MLKQSNGSIV VVSSLAGKVA YPMVAAYSAS KFALDGFFSS IRKEYSVSRV NVSITLCVLG LIDTETAMKA VSGIVHMQAA PKEECALEII KGGALRQEEV YYDSSRWTTL LIRNPCRKIL EELYSTSYNM DRFINK // ID 3TFQD STANDARD; PRT; 286 AA. DT CONVERTED FROM PDB (SEQRES) 3TFQ DE Corticosteroid 11-beta-dehydrogenase isozyme 1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.800 CC R-Factor 0.166 FT #SUB 15 21 ARG D 20 26 GLU A Protein S 4 FT #SUB 257 263 TRP D 272 278 GLU A Protein S 3 FT #SUB 257 263 TRP D 273 279 LEU A Protein S 1 FT #SUB 257 263 TRP D 276 282 THR A Protein S 2 FT #SUB 260 266 LEU D 269 275 ILE A Protein B 2 FT #SUB 260 266 LEU D 272 278 GLU A Protein S 5 FT #SUB 261 267 LEU D 269 275 ILE A Protein S 1 FT #SUB 265 271 PRO D 265 271 PRO A Protein S 3 FT #SUB 269 275 ILE D 260 266 LEU A Protein S 2 FT #SUB 269 275 ILE D 261 267 LEU A Protein S 1 FT #SUB 272 278 GLU D 257 263 TRP A Protein B 2 FT #SUB 272 278 GLU D 260 266 LEU A Protein S 2 FT #SUB 276 282 THR D 257 263 TRP A Protein S 2 FT #SUB 269 275 ILE D 266 272 CYS B Protein S 1 FT #SUB 90 96 MET D 131 137 ARG E Protein S 1 FT #SUB 121 127 ASN D 194 200 GLU E Protein B 1 FT #SUB 122 128 LEU D 194 200 GLU E Protein A 7 FT #SUB 122 128 LEU D 198 204 SER E Protein S 2 FT #SUB 123 129 PHE D 142 148 VAL E Protein S 1 FT #SUB 123 129 PHE D 146 152 VAL E Protein S 2 FT #SUB 123 129 PHE D 187 193 PHE E Protein S 6 FT #SUB 123 129 PHE D 191 197 ILE E Protein S 1 FT #SUB 123 129 PHE D 194 200 GLU E Protein A 5 FT #SUB 124 130 HIS D 146 152 VAL E Protein B 2 FT #SUB 125 131 ASP D 146 152 VAL E Protein S 1 FT #SUB 127 133 ILE D 139 145 LEU E Protein S 1 FT #SUB 127 133 ILE D 142 148 VAL E Protein S 2 FT #SUB 127 133 ILE D 143 149 VAL E Protein S 2 FT #SUB 130 136 VAL D 138 144 PHE E Protein S 2 FT #SUB 130 136 VAL D 139 145 LEU E Protein S 1 FT #SUB 130 136 VAL D 187 193 PHE E Protein S 1 FT #SUB 131 137 ARG D 90 96 MET E Protein S 2 FT #SUB 131 137 ARG D 135 141 GLU E Protein S 10 FT #SUB 131 137 ARG D 139 145 LEU E Protein A 2 FT #SUB 134 140 MET D 134 140 MET E Protein S 2 FT #SUB 134 140 MET D 138 144 PHE E Protein S 1 FT #SUB 135 141 GLU D 131 137 ARG E Protein S 7 FT #SUB 138 144 PHE D 130 136 VAL E Protein S 2 FT #SUB 138 144 PHE D 134 140 MET E Protein S 2 FT #SUB 138 144 PHE D 179 185 ALA E Protein S 1 FT #SUB 139 145 LEU D 127 133 ILE E Protein S 3 FT #SUB 139 145 LEU D 130 136 VAL E Protein S 1 FT #SUB 139 145 LEU D 131 137 ARG E Protein S 5 FT #SUB 142 148 VAL D 123 129 PHE E Protein S 1 FT #SUB 142 148 VAL D 127 133 ILE E Protein S 2 FT #SUB 143 149 VAL D 127 133 ILE E Protein S 2 FT #SUB 146 152 VAL D 123 129 PHE E Protein S 2 FT #SUB 146 152 VAL D 124 130 HIS E Protein S 2 FT #SUB 146 152 VAL D 125 131 ASP E Protein S 1 FT #SUB 165 171 LEU D 274 280 TYR E Protein S 3 FT #SUB 168 174 LYS D 267 273 ARG E Protein B 1 FT #SUB 169 175 VAL D 267 273 ARG E Protein S 1 FT #SUB 169 175 VAL D 271 277 GLU E Protein A 4 FT #SUB 169 175 VAL D 274 280 TYR E Protein S 1 FT #SUB 170 176 ALA D 189 195 SER E Protein S 3 FT #SUB 170 176 ALA D 193 199 LYS E Protein A 4 FT #SUB 170 176 ALA D 271 277 GLU E Protein A 5 FT #SUB 171 177 TYR D 190 196 SER E Protein B 4 FT #SUB 171 177 TYR D 274 280 TYR E Protein S 6 FT #SUB 172 178 PRO D 190 196 SER E Protein B 2 FT #SUB 172 178 PRO D 193 199 LYS E Protein S 1 FT #SUB 172 178 PRO D 194 200 GLU E Protein A 3 FT #SUB 173 179 MET D 194 200 GLU E Protein B 5 FT #SUB 175 181 ALA D 187 193 PHE E Protein A 4 FT #SUB 175 181 ALA D 190 196 SER E Protein A 5 FT #SUB 175 181 ALA D 191 197 ILE E Protein S 1 FT #SUB 178 184 SER D 186 192 GLY E Protein S 3 FT #SUB 179 185 ALA D 138 144 PHE E Protein S 1 FT #SUB 179 185 ALA D 183 189 ALA E Protein A 4 FT #SUB 179 185 ALA D 187 193 PHE E Protein S 2 FT #SUB 182 188 PHE D 182 188 PHE E Protein A 8 FT #SUB 182 188 PHE D 185 191 ASP E Protein S 2 FT #SUB 182 188 PHE D 186 192 GLY E Protein S 7 FT #SUB 182 188 PHE D 267 273 ARG E Protein S 1 FT #SUB 183 189 ALA D 179 185 ALA E Protein A 4 FT #SUB 185 191 ASP D 182 188 PHE E Protein S 2 FT #SUB 186 192 GLY D 178 184 SER E Protein B 3 FT #SUB 186 192 GLY D 182 188 PHE E Protein B 5 FT #SUB 187 193 PHE D 123 129 PHE E Protein S 6 FT #SUB 187 193 PHE D 130 136 VAL E Protein S 1 FT #SUB 187 193 PHE D 175 181 ALA E Protein S 4 FT #SUB 187 193 PHE D 179 185 ALA E Protein S 1 FT #SUB 189 195 SER D 170 176 ALA E Protein A 3 FT #SUB 190 196 SER D 171 177 TYR E Protein A 4 FT #SUB 190 196 SER D 172 178 PRO E Protein A 2 FT #SUB 190 196 SER D 175 181 ALA E Protein S 5 FT #SUB 191 197 ILE D 123 129 PHE E Protein S 1 FT #SUB 191 197 ILE D 175 181 ALA E Protein S 1 FT #SUB 193 199 LYS D 170 176 ALA E Protein S 4 FT #SUB 193 199 LYS D 172 178 PRO E Protein S 1 FT #SUB 194 200 GLU D 121 127 ASN E Protein S 1 FT #SUB 194 200 GLU D 122 128 LEU E Protein S 9 FT #SUB 194 200 GLU D 123 129 PHE E Protein S 5 FT #SUB 194 200 GLU D 172 178 PRO E Protein S 3 FT #SUB 194 200 GLU D 173 179 MET E Protein S 4 FT #SUB 198 204 SER D 122 128 LEU E Protein S 1 FT #SUB 224 230 ILE D 277 283 SER E Protein B 1 FT #SUB 225 231 VAL D 277 283 SER E Protein B 2 FT #SUB 226 232 HIS D 277 283 SER E Protein B 1 FT #SUB 227 233 MET D 277 283 SER E Protein S 1 FT #SUB 258 264 THR D 270 276 LEU E Protein B 1 FT #SUB 258 264 THR D 274 280 TYR E Protein A 6 FT #SUB 261 267 LEU D 266 272 CYS E Protein A 2 FT #SUB 261 267 LEU D 269 275 ILE E Protein S 1 FT #SUB 261 267 LEU D 270 276 LEU E Protein A 5 FT #SUB 261 267 LEU D 273 279 LEU E Protein S 1 FT #SUB 262 268 ILE D 270 276 LEU E Protein A 3 FT #SUB 264 270 ASN D 264 270 ASN E Protein S 3 FT #SUB 266 272 CYS D 261 267 LEU E Protein S 1 FT #SUB 267 273 ARG D 168 174 LYS E Protein S 1 FT #SUB 267 273 ARG D 169 175 VAL E Protein S 2 FT #SUB 267 273 ARG D 182 188 PHE E Protein S 1 FT #SUB 269 275 ILE D 261 267 LEU E Protein S 1 FT #SUB 270 276 LEU D 258 264 THR E Protein S 2 FT #SUB 270 276 LEU D 261 267 LEU E Protein S 4 FT #SUB 270 276 LEU D 262 268 ILE E Protein S 2 FT #SUB 271 277 GLU D 169 175 VAL E Protein S 4 FT #SUB 271 277 GLU D 170 176 ALA E Protein S 9 FT #SUB 273 279 LEU D 261 267 LEU E Protein S 1 FT #SUB 274 280 TYR D 165 171 LEU E Protein S 1 FT #SUB 274 280 TYR D 171 177 TYR E Protein S 3 FT #SUB 274 280 TYR D 227 233 MET E Protein S 4 FT #SUB 274 280 TYR D 253 259 ASP E Protein S 3 FT #SUB 274 280 TYR D 258 264 THR E Protein S 5 FT #SUB 276 282 THR D 226 232 HIS E Protein B 2 FT #SUB 277 283 SER D 225 231 VAL E Protein B 2 FT #SUB 277 283 SER D 226 232 HIS E Protein B 13 FT #SUB 277 283 SER D 227 233 MET E Protein S 3 FT #SUB 278 284 TYR D 171 177 TYR E Protein S 1 FT #SUB 278 284 TYR D 172 178 PRO E Protein S 5 FT #SUB 278 284 TYR D 173 179 MET E Protein S 2 FT #SUB 278 284 TYR D 224 230 ILE E Protein A 3 FT #SUB 278 284 TYR D 225 231 VAL E Protein S 1 FT #SUB 278 284 TYR D 226 232 HIS E Protein B 5 FT #HET 35 41 GLY D 5 301 NAP D B 8 FT #HET 36 42 ALA D 5 301 NAP D B 1 FT #HET 37 43 SER D 5 301 NAP D A 9 FT #HET 38 44 LYS D 5 301 NAP D A 6 FT #HET 39 45 GLY D 5 301 NAP D B 4 FT #HET 40 46 ILE D 5 301 NAP D A 8 FT #HET 59 65 ALA D 5 301 NAP D A 7 FT #HET 60 66 ARG D 5 301 NAP D A 27 FT #HET 61 67 SER D 5 301 NAP D A 3 FT #HET 85 91 GLY D 5 301 NAP D B 1 FT #HET 86 92 THR D 5 301 NAP D A 5 FT #HET 87 93 MET D 5 301 NAP D A 9 FT #HET 88 94 GLU D 5 301 NAP D S 1 FT #HET 113 119 ASN D 5 301 NAP D A 11 FT #HET 114 120 HIS D 5 301 NAP D A 3 FT #HET 115 121 ILE D 5 301 NAP D A 11 FT #HET 115 121 ILE D 6 302 07M D S 2 FT #HET 118 124 THR D 6 302 07M D A 7 FT #HET 119 125 SER D 6 302 07M D B 3 FT #HET 120 126 LEU D 6 302 07M D S 2 FT #HET 162 168 VAL D 5 301 NAP D A 6 FT #HET 163 169 SER D 5 301 NAP D B 3 FT #HET 164 170 SER D 5 301 NAP D S 3 FT #HET 164 170 SER D 6 302 07M D S 6 FT #HET 165 171 LEU D 6 302 07M D A 4 FT #HET 171 177 TYR D 6 302 07M D S 2 FT #HET 174 180 VAL D 6 302 07M D S 1 FT #HET 177 183 TYR D 5 301 NAP D S 7 FT #HET 177 183 TYR D 6 302 07M D S 14 FT #HET 181 187 LYS D 5 301 NAP D S 5 FT #HET 209 215 LEU D 5 301 NAP D A 5 FT #HET 209 215 LEU D 6 302 07M D B 1 FT #HET 210 216 GLY D 5 301 NAP D B 3 FT #HET 210 216 GLY D 6 302 07M D B 2 FT #HET 211 217 LEU D 5 301 NAP D A 3 FT #HET 211 217 LEU D 6 302 07M D B 1 FT #HET 212 218 ILE D 5 301 NAP D A 13 FT #HET 214 220 THR D 5 301 NAP D S 8 FT #HET 216 222 THR D 5 301 NAP D S 5 FT #HET 216 222 THR D 6 302 07M D S 2 FT #HET 217 223 ALA D 5 301 NAP D S 3 FT #HET 217 223 ALA D 6 302 07M D B 1 FT #HET 220 226 ALA D 6 302 07M D S 2 FT #HET 221 227 VAL D 6 302 07M D S 1 FT #HET 225 231 VAL D 6 302 07M D S 1 FT #HET 227 233 MET D 6 302 07M D S 1 FT DISORDER 1 3 FT DISORDER 279 286 CC SEQUENCE 275 AA (ATOM); CC MASMTGGQQM GRGSNEEFRP EMLQGKKVIV TGASKGIGRE MAYHLAKMGA HVVVTARSKE CC TLQKVVSHCL ELGAASAHYI AGTMEDMTFA EQFVAQAGKL MGGLDMLILN HITNTSLNLF CC HDDIHHVRKS MEVNFLSYVV LTVAALPMLK QSNGSIVVVS SLAGKVAYPM VAAYSASKFA CC LDGFFSSIRK EYSVSRVNVS ITLCVLGLID TETAMKAVSG IVHMQAAPKE ECALEIIKGG CC ALRQEEVYYD SSRWTTLLIR NPCRKILEEL YSTSY CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSHMASMTGGQQMGRGSNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAK CC ATOM ---MASMTGGQQMGRGSNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAK CC *********************************************** CC SEQRES MGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQA CC ATOM MGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQA CC ************************************************** CC SEQRES GKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP CC ATOM GKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP CC ************************************************** CC SEQRES MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRV CC ATOM MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRV CC ************************************************** CC SEQRES NVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEV CC ATOM NVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEV CC ************************************************** CC SEQRES YYDSSRWTTLLIRNPCRKILEELYSTSYNMDRFINK CC ATOM YYDSSRWTTLLIRNPCRKILEELYSTSY-------- CC **************************** SQ SEQUENCE 286 AA; MW; CN; GSHMASMTGG QQMGRGSNEE FRPEMLQGKK VIVTGASKGI GREMAYHLAK MGAHVVVTAR SKETLQKVVS HCLELGAASA HYIAGTMEDM TFAEQFVAQA GKLMGGLDML ILNHITNTSL NLFHDDIHHV RKSMEVNFLS YVVLTVAALP MLKQSNGSIV VVSSLAGKVA YPMVAAYSAS KFALDGFFSS IRKEYSVSRV NVSITLCVLG LIDTETAMKA VSGIVHMQAA PKEECALEII KGGALRQEEV YYDSSRWTTL LIRNPCRKIL EELYSTSYNM DRFINK // ID 3TFQE STANDARD; PRT; 286 AA. DT CONVERTED FROM PDB (SEQRES) 3TFQ DE Corticosteroid 11-beta-dehydrogenase isozyme 1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.800 CC R-Factor 0.166 FT #SUB 266 272 CYS E 269 275 ILE A Protein S 1 FT #SUB 256 262 ARG E 272 278 GLU B Protein S 4 FT #SUB 257 263 TRP E 269 275 ILE B Protein S 4 FT #SUB 257 263 TRP E 272 278 GLU B Protein S 6 FT #SUB 257 263 TRP E 273 279 LEU B Protein S 2 FT #SUB 260 266 LEU E 265 271 PRO B Protein A 3 FT #SUB 260 266 LEU E 268 274 LYS B Protein S 1 FT #SUB 261 267 LEU E 269 275 ILE B Protein S 2 FT #SUB 265 271 PRO E 260 266 LEU B Protein S 3 FT #SUB 269 275 ILE E 257 263 TRP B Protein S 5 FT #SUB 269 275 ILE E 261 267 LEU B Protein S 2 FT #SUB 272 278 GLU E 256 262 ARG B Protein S 1 FT #SUB 273 279 LEU E 257 263 TRP B Protein S 2 FT #SUB 90 96 MET E 131 137 ARG D Protein S 2 FT #SUB 121 127 ASN E 194 200 GLU D Protein B 1 FT #SUB 122 128 LEU E 194 200 GLU D Protein A 9 FT #SUB 122 128 LEU E 198 204 SER D Protein S 1 FT #SUB 123 129 PHE E 142 148 VAL D Protein S 1 FT #SUB 123 129 PHE E 146 152 VAL D Protein S 2 FT #SUB 123 129 PHE E 187 193 PHE D Protein S 6 FT #SUB 123 129 PHE E 191 197 ILE D Protein S 1 FT #SUB 123 129 PHE E 194 200 GLU D Protein A 5 FT #SUB 124 130 HIS E 146 152 VAL D Protein B 2 FT #SUB 125 131 ASP E 146 152 VAL D Protein S 1 FT #SUB 127 133 ILE E 139 145 LEU D Protein S 3 FT #SUB 127 133 ILE E 142 148 VAL D Protein S 2 FT #SUB 127 133 ILE E 143 149 VAL D Protein S 2 FT #SUB 130 136 VAL E 138 144 PHE D Protein S 2 FT #SUB 130 136 VAL E 139 145 LEU D Protein S 1 FT #SUB 130 136 VAL E 187 193 PHE D Protein S 1 FT #SUB 131 137 ARG E 90 96 MET D Protein S 1 FT #SUB 131 137 ARG E 135 141 GLU D Protein S 7 FT #SUB 131 137 ARG E 139 145 LEU D Protein A 5 FT #SUB 134 140 MET E 134 140 MET D Protein S 2 FT #SUB 134 140 MET E 138 144 PHE D Protein S 2 FT #SUB 135 141 GLU E 131 137 ARG D Protein S 10 FT #SUB 138 144 PHE E 130 136 VAL D Protein S 2 FT #SUB 138 144 PHE E 134 140 MET D Protein S 1 FT #SUB 138 144 PHE E 179 185 ALA D Protein S 1 FT #SUB 139 145 LEU E 127 133 ILE D Protein B 1 FT #SUB 139 145 LEU E 130 136 VAL D Protein S 1 FT #SUB 139 145 LEU E 131 137 ARG D Protein S 2 FT #SUB 142 148 VAL E 123 129 PHE D Protein S 1 FT #SUB 142 148 VAL E 127 133 ILE D Protein S 2 FT #SUB 143 149 VAL E 127 133 ILE D Protein S 2 FT #SUB 146 152 VAL E 123 129 PHE D Protein S 2 FT #SUB 146 152 VAL E 124 130 HIS D Protein S 2 FT #SUB 146 152 VAL E 125 131 ASP D Protein S 1 FT #SUB 165 171 LEU E 274 280 TYR D Protein S 1 FT #SUB 168 174 LYS E 267 273 ARG D Protein B 1 FT #SUB 169 175 VAL E 267 273 ARG D Protein S 2 FT #SUB 169 175 VAL E 271 277 GLU D Protein A 4 FT #SUB 170 176 ALA E 189 195 SER D Protein S 3 FT #SUB 170 176 ALA E 193 199 LYS D Protein A 4 FT #SUB 170 176 ALA E 271 277 GLU D Protein A 9 FT #SUB 171 177 TYR E 190 196 SER D Protein B 4 FT #SUB 171 177 TYR E 274 280 TYR D Protein S 3 FT #SUB 171 177 TYR E 278 284 TYR D Protein S 1 FT #SUB 172 178 PRO E 190 196 SER D Protein B 2 FT #SUB 172 178 PRO E 193 199 LYS D Protein S 1 FT #SUB 172 178 PRO E 194 200 GLU D Protein A 3 FT #SUB 172 178 PRO E 278 284 TYR D Protein A 5 FT #SUB 173 179 MET E 194 200 GLU D Protein B 4 FT #SUB 173 179 MET E 278 284 TYR D Protein S 2 FT #SUB 175 181 ALA E 187 193 PHE D Protein A 4 FT #SUB 175 181 ALA E 190 196 SER D Protein A 5 FT #SUB 175 181 ALA E 191 197 ILE D Protein S 1 FT #SUB 178 184 SER E 186 192 GLY D Protein S 3 FT #SUB 179 185 ALA E 138 144 PHE D Protein S 1 FT #SUB 179 185 ALA E 183 189 ALA D Protein A 4 FT #SUB 179 185 ALA E 187 193 PHE D Protein S 1 FT #SUB 182 188 PHE E 182 188 PHE D Protein A 8 FT #SUB 182 188 PHE E 185 191 ASP D Protein S 2 FT #SUB 182 188 PHE E 186 192 GLY D Protein S 5 FT #SUB 182 188 PHE E 267 273 ARG D Protein S 1 FT #SUB 183 189 ALA E 179 185 ALA D Protein A 4 FT #SUB 185 191 ASP E 182 188 PHE D Protein S 2 FT #SUB 186 192 GLY E 178 184 SER D Protein B 3 FT #SUB 186 192 GLY E 182 188 PHE D Protein B 7 FT #SUB 187 193 PHE E 123 129 PHE D Protein S 6 FT #SUB 187 193 PHE E 130 136 VAL D Protein S 1 FT #SUB 187 193 PHE E 175 181 ALA D Protein S 4 FT #SUB 187 193 PHE E 179 185 ALA D Protein A 2 FT #SUB 189 195 SER E 170 176 ALA D Protein A 3 FT #SUB 190 196 SER E 171 177 TYR D Protein A 4 FT #SUB 190 196 SER E 172 178 PRO D Protein A 2 FT #SUB 190 196 SER E 175 181 ALA D Protein S 5 FT #SUB 191 197 ILE E 123 129 PHE D Protein S 1 FT #SUB 191 197 ILE E 175 181 ALA D Protein S 1 FT #SUB 193 199 LYS E 170 176 ALA D Protein S 4 FT #SUB 193 199 LYS E 172 178 PRO D Protein S 1 FT #SUB 194 200 GLU E 121 127 ASN D Protein S 1 FT #SUB 194 200 GLU E 122 128 LEU D Protein S 7 FT #SUB 194 200 GLU E 123 129 PHE D Protein S 5 FT #SUB 194 200 GLU E 172 178 PRO D Protein S 3 FT #SUB 194 200 GLU E 173 179 MET D Protein S 5 FT #SUB 198 204 SER E 122 128 LEU D Protein S 2 FT #SUB 224 230 ILE E 278 284 TYR D Protein B 3 FT #SUB 225 231 VAL E 277 283 SER D Protein B 2 FT #SUB 225 231 VAL E 278 284 TYR D Protein S 1 FT #SUB 226 232 HIS E 276 282 THR D Protein S 2 FT #SUB 226 232 HIS E 277 283 SER D Protein A 13 FT #SUB 226 232 HIS E 278 284 TYR D Protein S 5 FT #SUB 227 233 MET E 274 280 TYR D Protein S 4 FT #SUB 227 233 MET E 277 283 SER D Protein S 3 FT #SUB 253 259 ASP E 274 280 TYR D Protein S 3 FT #SUB 258 264 THR E 270 276 LEU D Protein A 2 FT #SUB 258 264 THR E 274 280 TYR D Protein S 5 FT #SUB 261 267 LEU E 266 272 CYS D Protein B 1 FT #SUB 261 267 LEU E 269 275 ILE D Protein S 1 FT #SUB 261 267 LEU E 270 276 LEU D Protein S 4 FT #SUB 261 267 LEU E 273 279 LEU D Protein S 1 FT #SUB 262 268 ILE E 270 276 LEU D Protein A 2 FT #SUB 264 270 ASN E 264 270 ASN D Protein S 3 FT #SUB 266 272 CYS E 261 267 LEU D Protein S 2 FT #SUB 267 273 ARG E 168 174 LYS D Protein S 1 FT #SUB 267 273 ARG E 169 175 VAL D Protein S 1 FT #SUB 267 273 ARG E 182 188 PHE D Protein S 1 FT #SUB 269 275 ILE E 261 267 LEU D Protein S 1 FT #SUB 270 276 LEU E 258 264 THR D Protein S 1 FT #SUB 270 276 LEU E 261 267 LEU D Protein S 5 FT #SUB 270 276 LEU E 262 268 ILE D Protein S 3 FT #SUB 271 277 GLU E 169 175 VAL D Protein S 4 FT #SUB 271 277 GLU E 170 176 ALA D Protein S 5 FT #SUB 273 279 LEU E 261 267 LEU D Protein S 1 FT #SUB 274 280 TYR E 165 171 LEU D Protein S 3 FT #SUB 274 280 TYR E 169 175 VAL D Protein S 1 FT #SUB 274 280 TYR E 171 177 TYR D Protein S 6 FT #SUB 274 280 TYR E 258 264 THR D Protein S 6 FT #SUB 277 283 SER E 224 230 ILE D Protein B 1 FT #SUB 277 283 SER E 225 231 VAL D Protein B 2 FT #SUB 277 283 SER E 226 232 HIS D Protein B 1 FT #SUB 277 283 SER E 227 233 MET D Protein S 1 FT #HET 35 41 GLY E 7 301 NAP E B 9 FT #HET 36 42 ALA E 7 301 NAP E B 1 FT #HET 37 43 SER E 7 301 NAP E A 8 FT #HET 38 44 LYS E 7 301 NAP E A 6 FT #HET 39 45 GLY E 7 301 NAP E B 4 FT #HET 40 46 ILE E 7 301 NAP E A 7 FT #HET 59 65 ALA E 7 301 NAP E A 7 FT #HET 60 66 ARG E 7 301 NAP E A 29 FT #HET 61 67 SER E 7 301 NAP E A 3 FT #HET 85 91 GLY E 7 301 NAP E B 1 FT #HET 86 92 THR E 7 301 NAP E A 5 FT #HET 87 93 MET E 7 301 NAP E A 9 FT #HET 88 94 GLU E 7 301 NAP E S 2 FT #HET 113 119 ASN E 7 301 NAP E A 11 FT #HET 114 120 HIS E 7 301 NAP E A 3 FT #HET 115 121 ILE E 7 301 NAP E A 12 FT #HET 115 121 ILE E 8 302 07M E S 2 FT #HET 117 123 ASN E 7 301 NAP E S 1 FT #HET 118 124 THR E 8 302 07M E A 6 FT #HET 119 125 SER E 8 302 07M E B 3 FT #HET 120 126 LEU E 8 302 07M E S 5 FT #HET 141 147 TYR E 7 301 NAP E S 1 FT #HET 162 168 VAL E 7 301 NAP E A 5 FT #HET 163 169 SER E 7 301 NAP E B 3 FT #HET 164 170 SER E 7 301 NAP E S 3 FT #HET 164 170 SER E 8 302 07M E S 6 FT #HET 165 171 LEU E 8 302 07M E A 3 FT #HET 171 177 TYR E 8 302 07M E S 2 FT #HET 174 180 VAL E 8 302 07M E S 2 FT #HET 177 183 TYR E 7 301 NAP E S 7 FT #HET 177 183 TYR E 8 302 07M E S 15 FT #HET 181 187 LYS E 7 301 NAP E S 5 FT #HET 201 207 ASN E 9 351 GOL E B 2 FT #HET 202 208 VAL E 9 351 GOL E B 2 FT #HET 203 209 SER E 9 351 GOL E A 4 FT #HET 209 215 LEU E 7 301 NAP E A 5 FT #HET 209 215 LEU E 8 302 07M E B 1 FT #HET 210 216 GLY E 7 301 NAP E B 4 FT #HET 210 216 GLY E 8 302 07M E B 2 FT #HET 211 217 LEU E 7 301 NAP E A 3 FT #HET 211 217 LEU E 8 302 07M E B 1 FT #HET 212 218 ILE E 7 301 NAP E A 11 FT #HET 214 220 THR E 7 301 NAP E S 7 FT #HET 216 222 THR E 7 301 NAP E S 5 FT #HET 216 222 THR E 8 302 07M E S 2 FT #HET 217 223 ALA E 7 301 NAP E S 3 FT #HET 217 223 ALA E 8 302 07M E A 4 FT #HET 220 226 ALA E 8 302 07M E S 2 FT #HET 225 231 VAL E 8 302 07M E S 1 FT #HET 227 233 MET E 8 302 07M E S 1 FT #HET 246 252 ARG E 9 351 GOL E A 10 FT DISORDER 1 18 FT DISORDER 278 286 CC SEQUENCE 259 AA (ATOM); CC EEFRPEMLQG KKVIVTGASK GIGREMAYHL AKMGAHVVVT ARSKETLQKV VSHCLELGAA CC SAHYIAGTME DMTFAEQFVA QAGKLMGGLD MLILNHITNT SLNLFHDDIH HVRKSMEVNF CC LSYVVLTVAA LPMLKQSNGS IVVVSSLAGK VAYPMVAAYS ASKFALDGFF SSIRKEYSVS CC RVNVSITLCV LGLIDTETAM KAVSGIVHMQ AAPKEECALE IIKGGALRQE EVYYDSSRWT CC TLLIRNPCRK ILEELYSTS CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSHMASMTGGQQMGRGSNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAK CC ATOM ------------------EEFRPEMLQGKKVIVTGASKGIGREMAYHLAK CC ******************************** CC SEQRES MGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQA CC ATOM MGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQA CC ************************************************** CC SEQRES GKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP CC ATOM GKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP CC ************************************************** CC SEQRES MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRV CC ATOM MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRV CC ************************************************** CC SEQRES NVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEV CC ATOM NVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEV CC ************************************************** CC SEQRES YYDSSRWTTLLIRNPCRKILEELYSTSYNMDRFINK CC ATOM YYDSSRWTTLLIRNPCRKILEELYSTS--------- CC *************************** SQ SEQUENCE 286 AA; MW; CN; GSHMASMTGG QQMGRGSNEE FRPEMLQGKK VIVTGASKGI GREMAYHLAK MGAHVVVTAR SKETLQKVVS HCLELGAASA HYIAGTMEDM TFAEQFVAQA GKLMGGLDML ILNHITNTSL NLFHDDIHHV RKSMEVNFLS YVVLTVAALP MLKQSNGSIV VVSSLAGKVA YPMVAAYSAS KFALDGFFSS IRKEYSVSRV NVSITLCVLG LIDTETAMKA VSGIVHMQAA PKEECALEII KGGALRQEEV YYDSSRWTTL LIRNPCRKIL EELYSTSYNM DRFINK //