ID 3SL6A STANDARD; PRT; 361 AA. DT CONVERTED FROM PDB (SEQRES) 3SL6 DE cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.440 CC R-Factor 0.201 FT #SUB 142 220 ALA A 183 261 ARG B Protein B 1 FT #SUB 143 221 LEU A 183 261 ARG B Protein A 5 FT #SUB 144 222 MET A 144 222 MET B Protein S 1 FT #SUB 144 222 MET A 145 223 TYR B Protein A 2 FT #SUB 145 223 TYR A 144 222 MET B Protein S 3 FT #SUB 146 224 ASN A 153 231 ASN B Protein S 4 FT #SUB 146 224 ASN A 156 234 LEU B Protein S 4 FT #SUB 146 224 ASN A 187 265 ILE B Protein A 5 FT #SUB 147 225 ASP A 183 261 ARG B Protein A 8 FT #SUB 153 231 ASN A 146 224 ASN B Protein A 9 FT #SUB 156 234 LEU A 146 224 ASN B Protein A 4 FT #SUB 157 235 ALA A 143 221 LEU B Protein S 1 FT #SUB 157 235 ALA A 146 224 ASN B Protein B 2 FT #SUB 176 254 LYS A 136 214 ASN B Protein S 3 FT #SUB 176 254 LYS A 138 216 ASN B Protein S 3 FT #SUB 180 258 GLN A 136 214 ASN B Protein S 3 FT #SUB 183 261 ARG A 142 220 ALA B Protein S 2 FT #SUB 183 261 ARG A 143 221 LEU B Protein S 1 FT #SUB 183 261 ARG A 146 224 ASN B Protein S 1 FT #SUB 183 261 ARG A 147 225 ASP B Protein S 11 FT #SUB 187 265 ILE A 146 224 ASN B Protein S 4 FT #SUB 187 265 ILE A 147 225 ASP B Protein S 1 FT #SUB 38 116 ARG A 271 349 GLU C Protein S 6 FT #SUB 69 147 MET A 271 349 GLU C Protein S 7 FT #SUB 70 148 THR A 272 350 ARG C Protein A 4 FT #SUB 73 151 ASP A 268 346 ARG C Protein S 10 FT #SUB 73 151 ASP A 272 350 ARG C Protein S 3 FT #SUB 78 156 ASP A 77 155 ALA C Protein S 3 FT #SUB 78 156 ASP A 78 156 ASP C Protein S 3 FT #SUB 136 214 ASN A 166 244 GLU C Protein B 1 FT #SUB 137 215 THR A 165 243 GLU C Protein A 7 FT #SUB 137 215 THR A 166 244 GLU C Protein B 5 FT #SUB 138 216 ASN A 164 242 GLN C Protein S 1 FT #SUB 138 216 ASN A 166 244 GLU C Protein S 1 FT #SUB 139 217 SER A 165 243 GLU C Protein A 2 FT #SUB 140 218 GLU A 161 239 LYS C Protein S 1 FT #SUB 165 243 GLU A 137 215 THR C Protein A 7 FT #SUB 165 243 GLU A 139 217 SER C Protein S 2 FT #SUB 166 244 GLU A 136 214 ASN C Protein S 1 FT #SUB 166 244 GLU A 137 215 THR C Protein A 6 FT #SUB 166 244 GLU A 138 216 ASN C Protein A 7 FT #SUB 268 346 ARG A 73 151 ASP C Protein S 7 FT #SUB 271 349 GLU A 38 116 ARG C Protein S 8 FT #SUB 271 349 GLU A 69 147 MET C Protein A 9 FT #SUB 272 350 ARG A 70 148 THR C Protein S 4 FT #SUB 272 350 ARG A 73 151 ASP C Protein S 1 FT #SUB 161 239 LYS A 161 239 LYS D Protein S 2 FT #SUB 164 242 GLN A 161 239 LYS D Protein S 1 FT #SUB 164 242 GLN A 164 242 GLN D Protein S 7 FT #SUB 166 244 GLU A 176 254 LYS D Protein S 7 FT #SUB 166 244 GLU A 179 257 ARG D Protein S 8 FT #SUB 176 254 LYS A 166 244 GLU D Protein S 8 FT #SUB 179 257 ARG A 166 244 GLU D Protein S 8 FT #HET 37 115 ASN A 6 6 EDO A B 1 FT #HET 38 116 ARG A 6 6 EDO A S 1 FT #HET 56 134 THR A 4 4 EDO A B 4 FT #HET 58 136 LYS A 4 4 EDO A S 2 FT #HET 70 148 THR A 12 442 EDO A S 2 FT #HET 72 150 GLU A 6 6 EDO A A 7 FT #HET 73 151 ASP A 6 6 EDO A A 4 FT #HET 74 152 HIS A 12 442 EDO A S 3 FT #HET 75 153 TYR A 6 6 EDO A B 2 FT #HET 78 156 ASP A 7 7 EDO A B 3 FT #HET 79 157 VAL A 7 7 EDO A B 2 FT #HET 80 158 ALA A 7 7 EDO A A 4 FT #HET 81 159 TYR A 10 440 JN8 A S 3 FT #HET 84 162 ASN A 6 6 EDO A S 3 FT #HET 86 164 HIS A 1 10 ZN A S 3 FT #HET 97 175 LEU A 5 5 EDO A A 4 FT #HET 100 178 THR A 5 5 EDO A S 8 FT #HET 122 200 HIS A 1 10 ZN A S 3 FT #HET 123 201 ASP A 1 10 ZN A S 3 FT #HET 123 201 ASP A 2 11 ZN A S 3 FT #HET 127 205 PRO A 7 7 EDO A B 1 FT #HET 133 211 PHE A 20 3 EDO C S 1 FT #HET 139 217 SER A 20 3 EDO C S 1 FT #HET 140 218 GLU A 3 2 EDO A S 10 FT #HET 160 238 PHE A 9 9 EDO A S 2 FT #HET 165 243 GLU A 12 442 EDO A S 9 FT #HET 171 249 PHE A 9 9 EDO A S 2 FT #HET 179 257 ARG A 9 9 EDO A A 5 FT #HET 183 261 ARG A 9 9 EDO A S 3 FT #HET 184 262 LYS A 11 441 EDO A S 8 FT #HET 187 265 ILE A 11 441 EDO A S 1 FT #HET 188 266 ASP A 11 441 EDO A S 4 FT #HET 195 273 MET A 10 440 JN8 A S 2 FT #HET 197 275 LYS A 8 8 EDO A S 1 FT #HET 200 278 ASN A 8 8 EDO A A 2 FT #HET 201 279 LEU A 8 8 EDO A B 1 FT #HET 240 318 ASP A 1 10 ZN A S 3 FT #HET 240 318 ASP A 10 440 JN8 A B 2 FT #HET 241 319 LEU A 10 440 JN8 A S 2 FT #HET 243 321 ASN A 10 440 JN8 A S 6 FT #HET 244 322 PRO A 10 440 JN8 A S 4 FT #HET 251 329 TYR A 10 440 JN8 A S 2 FT #HET 255 333 THR A 10 440 JN8 A S 1 FT #HET 258 336 ILE A 10 440 JN8 A S 3 FT #HET 259 337 MET A 10 440 JN8 A S 1 FT #HET 261 339 GLU A 7 7 EDO A A 2 FT #HET 262 340 PHE A 10 440 JN8 A S 4 FT #HET 268 346 ARG A 7 7 EDO A S 1 FT #HET 272 350 ARG A 20 3 EDO C S 2 FT #HET 279 357 MET A 10 440 JN8 A S 3 FT #HET 290 368 SER A 10 440 JN8 A A 8 FT #HET 291 369 GLN A 10 440 JN8 A S 8 FT #HET 294 372 PHE A 10 440 JN8 A S 22 FT #HET 298 376 ILE A 10 440 JN8 A S 2 FT #HET 306 384 TRP A 5 5 EDO A S 3 FT #HET 310 388 VAL A 5 5 EDO A S 1 FT #HET 313 391 ASP A 5 5 EDO A A 3 FT #HET 317 395 ILE A 5 5 EDO A S 1 FT DISORDER 1 5 FT DISORDER 333 361 CC SEQUENCE 327 AA (ATOM); CC VKTEQEDVLA KELEDVNKWG LHVFRIAELS GNRPLTVIMH TIFQERDLLK TFKIPVDTLI CC TYLMTLEDHY HADVAYHNNI HAADVVQSTH VLLSTPALEA VFTDLEILAA IFASAIHDVD CC HPGVSNQFLI NTNSELALMY NDSSVLENHH LAVGFKLLQE ENCDIFQNLT KKQRQSLRKM CC VIDIVLATDM SKHMNLLADL KTMVETKKVT SSGVLLLDNY SDRIQVLQNM VHCADLSNPT CC KPLQLYRQWT DRIMEEFFRQ GDRERERGME ISPMCDKHNA SVEKSQVGFI DYIVHPLWET CC WADLVHPDAQ DILDTLEDNR EWYQSTI CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES IPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE CC ATOM -----VKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE CC ********************************************* CC SEQRES RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST CC ATOM RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST CC ************************************************** CC SEQRES PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSV CC ATOM PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSV CC ************************************************** CC SEQRES LENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN CC ATOM LENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN CC ************************************************** CC SEQRES LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL CC ATOM LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL CC ************************************************** CC SEQRES YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH CC ATOM YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH CC ************************************************** CC SEQRES PLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQ CC ATOM PLWETWADLVHPDAQDILDTLEDNREWYQSTI------------------ CC ******************************** CC SEQRES TEKFQFELTLE CC ATOM ----------- CC SQ SEQUENCE 361 AA; MW; CN; IPRFGVKTEQ EDVLAKELED VNKWGLHVFR IAELSGNRPL TVIMHTIFQE RDLLKTFKIP VDTLITYLMT LEDHYHADVA YHNNIHAADV VQSTHVLLST PALEAVFTDL EILAAIFASA IHDVDHPGVS NQFLINTNSE LALMYNDSSV LENHHLAVGF KLLQEENCDI FQNLTKKQRQ SLRKMVIDIV LATDMSKHMN LLADLKTMVE TKKVTSSGVL LLDNYSDRIQ VLQNMVHCAD LSNPTKPLQL YRQWTDRIME EFFRQGDRER ERGMEISPMC DKHNASVEKS QVGFIDYIVH PLWETWADLV HPDAQDILDT LEDNREWYQS TIPQSPSPAP DDPEEGRQGQ TEKFQFELTL E // ID 3SL6B STANDARD; PRT; 361 AA. DT CONVERTED FROM PDB (SEQRES) 3SL6 DE cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.440 CC R-Factor 0.201 FT #SUB 136 214 ASN B 176 254 LYS A Protein B 3 FT #SUB 136 214 ASN B 180 258 GLN A Protein S 3 FT #SUB 138 216 ASN B 176 254 LYS A Protein S 3 FT #SUB 142 220 ALA B 183 261 ARG A Protein B 2 FT #SUB 143 221 LEU B 157 235 ALA A Protein B 1 FT #SUB 143 221 LEU B 183 261 ARG A Protein B 1 FT #SUB 144 222 MET B 144 222 MET A Protein S 1 FT #SUB 144 222 MET B 145 223 TYR A Protein B 3 FT #SUB 145 223 TYR B 144 222 MET A Protein S 2 FT #SUB 146 224 ASN B 153 231 ASN A Protein S 9 FT #SUB 146 224 ASN B 156 234 LEU A Protein S 4 FT #SUB 146 224 ASN B 157 235 ALA A Protein S 2 FT #SUB 146 224 ASN B 183 261 ARG A Protein B 1 FT #SUB 146 224 ASN B 187 265 ILE A Protein B 4 FT #SUB 147 225 ASP B 183 261 ARG A Protein A 11 FT #SUB 147 225 ASP B 187 265 ILE A Protein S 1 FT #SUB 153 231 ASN B 146 224 ASN A Protein A 4 FT #SUB 156 234 LEU B 146 224 ASN A Protein S 4 FT #SUB 183 261 ARG B 142 220 ALA A Protein S 1 FT #SUB 183 261 ARG B 143 221 LEU A Protein S 5 FT #SUB 183 261 ARG B 147 225 ASP A Protein S 8 FT #SUB 187 265 ILE B 146 224 ASN A Protein S 5 FT #SUB 161 239 LYS B 161 239 LYS C Protein S 1 FT #SUB 166 244 GLU B 176 254 LYS C Protein S 3 FT #SUB 176 254 LYS B 166 244 GLU C Protein S 4 FT #SUB 38 116 ARG B 271 349 GLU D Protein S 8 FT #SUB 69 147 MET B 271 349 GLU D Protein S 4 FT #SUB 70 148 THR B 272 350 ARG D Protein A 5 FT #SUB 73 151 ASP B 268 346 ARG D Protein S 8 FT #SUB 73 151 ASP B 272 350 ARG D Protein S 3 FT #SUB 77 155 ALA B 78 156 ASP D Protein S 1 FT #SUB 136 214 ASN B 166 244 GLU D Protein B 1 FT #SUB 137 215 THR B 165 243 GLU D Protein A 7 FT #SUB 137 215 THR B 166 244 GLU D Protein B 2 FT #SUB 138 216 ASN B 165 243 GLU D Protein B 1 FT #SUB 138 216 ASN B 166 244 GLU D Protein S 7 FT #SUB 139 217 SER B 165 243 GLU D Protein A 4 FT #SUB 140 218 GLU B 161 239 LYS D Protein S 4 FT #SUB 161 239 LYS B 140 218 GLU D Protein S 2 FT #SUB 164 242 GLN B 138 216 ASN D Protein B 1 FT #SUB 165 243 GLU B 137 215 THR D Protein A 4 FT #SUB 165 243 GLU B 139 217 SER D Protein S 3 FT #SUB 166 244 GLU B 136 214 ASN D Protein S 2 FT #SUB 166 244 GLU B 137 215 THR D Protein A 6 FT #SUB 268 346 ARG B 73 151 ASP D Protein S 8 FT #SUB 271 349 GLU B 38 116 ARG D Protein S 11 FT #SUB 271 349 GLU B 69 147 MET D Protein A 7 FT #SUB 272 350 ARG B 70 148 THR D Protein S 3 FT #SUB 272 350 ARG B 73 151 ASP D Protein S 4 FT #HET 17 95 GLU B 19 14 DMS B S 1 FT #HET 20 98 ASP B 19 14 DMS B S 1 FT #HET 25 103 GLY B 19 14 DMS B B 1 FT #HET 27 105 HIS B 19 14 DMS B A 7 FT #HET 37 115 ASN B 15 4 EDO B A 3 FT #HET 38 116 ARG B 15 4 EDO B S 4 FT #HET 72 150 GLU B 15 4 EDO B A 5 FT #HET 73 151 ASP B 15 4 EDO B A 5 FT #HET 75 153 TYR B 15 4 EDO B B 2 FT #HET 77 155 ALA B 15 4 EDO B S 1 FT #HET 81 159 TYR B 18 440 JN8 B S 1 FT #HET 84 162 ASN B 15 4 EDO B S 1 FT #HET 86 164 HIS B 13 7 ZN B S 3 FT #HET 98 176 LEU B 16 5 EDO B B 3 FT #HET 99 177 SER B 16 5 EDO B B 3 FT #HET 100 178 THR B 16 5 EDO B B 3 FT #HET 103 181 LEU B 16 5 EDO B B 3 FT #HET 104 182 GLU B 16 5 EDO B A 9 FT #HET 105 183 ALA B 16 5 EDO B B 1 FT #HET 122 200 HIS B 13 7 ZN B S 3 FT #HET 123 201 ASP B 13 7 ZN B S 3 FT #HET 123 201 ASP B 14 8 ZN B S 3 FT #HET 130 208 SER B 18 440 JN8 B S 1 FT #HET 133 211 PHE B 31 3 EDO D S 1 FT #HET 134 212 LEU B 31 3 EDO D S 1 FT #HET 137 215 THR B 31 3 EDO D S 1 FT #HET 146 224 ASN B 11 441 EDO A B 1 FT #HET 147 225 ASP B 11 441 EDO A S 1 FT #HET 195 273 MET B 18 440 JN8 B S 1 FT #HET 240 318 ASP B 13 7 ZN B S 3 FT #HET 241 319 LEU B 18 440 JN8 B S 2 FT #HET 243 321 ASN B 18 440 JN8 B S 5 FT #HET 244 322 PRO B 18 440 JN8 B S 2 FT #HET 251 329 TYR B 18 440 JN8 B S 2 FT #HET 255 333 THR B 18 440 JN8 B S 1 FT #HET 258 336 ILE B 18 440 JN8 B S 4 FT #HET 262 340 PHE B 18 440 JN8 B S 7 FT #HET 272 350 ARG B 31 3 EDO D S 4 FT #HET 279 357 MET B 18 440 JN8 B S 5 FT #HET 280 358 CYS B 18 440 JN8 B S 1 FT #HET 290 368 SER B 18 440 JN8 B A 7 FT #HET 291 369 GLN B 18 440 JN8 B S 9 FT #HET 294 372 PHE B 18 440 JN8 B S 17 FT #HET 296 374 ASP B 17 6 EDO B B 2 FT #HET 300 378 HIS B 17 6 EDO B A 12 FT #HET 301 379 PRO B 17 6 EDO B A 8 FT #HET 304 382 GLU B 17 6 EDO B S 3 FT DISORDER 1 9 FT DISORDER 335 361 CC SEQUENCE 325 AA (ATOM); CC QEDVLAKELE DVNKWGLHVF RIAELSGNRP LTVIMHTIFQ ERDLLKTFKI PVDTLITYLM CC TLEDHYHADV AYHNNIHAAD VVQSTHVLLS TPALEAVFTD LEILAAIFAS AIHDVDHPGV CC SNQFLINTNS ELALMYNDSS VLENHHLAVG FKLLQEENCD IFQNLTKKQR QSLRKMVIDI CC VLATDMSKHM NLLADLKTMV ETKKVTSSGV LLLDNYSDRI QVLQNMVHCA DLSNPTKPLQ CC LYRQWTDRIM EEFFRQGDRE RERGMEISPM CDKHNASVEK SQVGFIDYIV HPLWETWADL CC VHPDAQDILD TLEDNREWYQ STIPQ CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES IPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE CC ATOM ---------QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE CC ***************************************** CC SEQRES RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST CC ATOM RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST CC ************************************************** CC SEQRES PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSV CC ATOM PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSV CC ************************************************** CC SEQRES LENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN CC ATOM LENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN CC ************************************************** CC SEQRES LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL CC ATOM LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL CC ************************************************** CC SEQRES YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH CC ATOM YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH CC ************************************************** CC SEQRES PLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQ CC ATOM PLWETWADLVHPDAQDILDTLEDNREWYQSTIPQ---------------- CC ********************************** CC SEQRES TEKFQFELTLE CC ATOM ----------- CC SQ SEQUENCE 361 AA; MW; CN; IPRFGVKTEQ EDVLAKELED VNKWGLHVFR IAELSGNRPL TVIMHTIFQE RDLLKTFKIP VDTLITYLMT LEDHYHADVA YHNNIHAADV VQSTHVLLST PALEAVFTDL EILAAIFASA IHDVDHPGVS NQFLINTNSE LALMYNDSSV LENHHLAVGF KLLQEENCDI FQNLTKKQRQ SLRKMVIDIV LATDMSKHMN LLADLKTMVE TKKVTSSGVL LLDNYSDRIQ VLQNMVHCAD LSNPTKPLQL YRQWTDRIME EFFRQGDRER ERGMEISPMC DKHNASVEKS QVGFIDYIVH PLWETWADLV HPDAQDILDT LEDNREWYQS TIPQSPSPAP DDPEEGRQGQ TEKFQFELTL E // ID 3SL6C STANDARD; PRT; 361 AA. DT CONVERTED FROM PDB (SEQRES) 3SL6 DE cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.440 CC R-Factor 0.201 FT #SUB 38 116 ARG C 271 349 GLU A Protein S 8 FT #SUB 69 147 MET C 271 349 GLU A Protein S 9 FT #SUB 70 148 THR C 272 350 ARG A Protein A 4 FT #SUB 73 151 ASP C 268 346 ARG A Protein S 7 FT #SUB 73 151 ASP C 272 350 ARG A Protein S 1 FT #SUB 77 155 ALA C 78 156 ASP A Protein A 3 FT #SUB 78 156 ASP C 78 156 ASP A Protein S 3 FT #SUB 136 214 ASN C 166 244 GLU A Protein B 1 FT #SUB 137 215 THR C 165 243 GLU A Protein A 7 FT #SUB 137 215 THR C 166 244 GLU A Protein B 6 FT #SUB 138 216 ASN C 166 244 GLU A Protein S 7 FT #SUB 139 217 SER C 165 243 GLU A Protein A 2 FT #SUB 161 239 LYS C 140 218 GLU A Protein S 1 FT #SUB 164 242 GLN C 138 216 ASN A Protein B 1 FT #SUB 165 243 GLU C 137 215 THR A Protein A 7 FT #SUB 165 243 GLU C 139 217 SER A Protein S 2 FT #SUB 166 244 GLU C 136 214 ASN A Protein S 1 FT #SUB 166 244 GLU C 137 215 THR A Protein A 5 FT #SUB 166 244 GLU C 138 216 ASN A Protein B 1 FT #SUB 268 346 ARG C 73 151 ASP A Protein S 10 FT #SUB 271 349 GLU C 38 116 ARG A Protein S 6 FT #SUB 271 349 GLU C 69 147 MET A Protein S 7 FT #SUB 272 350 ARG C 70 148 THR A Protein S 4 FT #SUB 272 350 ARG C 73 151 ASP A Protein S 3 FT #SUB 161 239 LYS C 161 239 LYS B Protein S 1 FT #SUB 166 244 GLU C 176 254 LYS B Protein S 4 FT #SUB 176 254 LYS C 166 244 GLU B Protein S 3 FT #SUB 136 214 ASN C 176 254 LYS D Protein B 3 FT #SUB 136 214 ASN C 180 258 GLN D Protein S 2 FT #SUB 138 216 ASN C 176 254 LYS D Protein S 3 FT #SUB 142 220 ALA C 183 261 ARG D Protein B 2 FT #SUB 143 221 LEU C 157 235 ALA D Protein S 1 FT #SUB 143 221 LEU C 160 238 PHE D Protein S 1 FT #SUB 143 221 LEU C 183 261 ARG D Protein A 2 FT #SUB 144 222 MET C 144 222 MET D Protein S 1 FT #SUB 144 222 MET C 145 223 TYR D Protein A 4 FT #SUB 145 223 TYR C 144 222 MET D Protein S 1 FT #SUB 146 224 ASN C 153 231 ASN D Protein S 6 FT #SUB 146 224 ASN C 156 234 LEU D Protein S 5 FT #SUB 146 224 ASN C 157 235 ALA D Protein S 1 FT #SUB 146 224 ASN C 183 261 ARG D Protein B 1 FT #SUB 146 224 ASN C 187 265 ILE D Protein A 5 FT #SUB 147 225 ASP C 183 261 ARG D Protein S 10 FT #SUB 153 231 ASN C 146 224 ASN D Protein S 3 FT #SUB 156 234 LEU C 146 224 ASN D Protein S 1 FT #SUB 183 261 ARG C 142 220 ALA D Protein S 1 FT #SUB 183 261 ARG C 143 221 LEU D Protein S 3 FT #SUB 183 261 ARG C 146 224 ASN D Protein S 2 FT #SUB 183 261 ARG C 147 225 ASP D Protein S 4 FT #SUB 187 265 ILE C 146 224 ASN D Protein S 7 FT #SUB 275 353 GLU C 180 258 GLN D Protein S 1 FT #HET 27 105 HIS C 23 2 EPE C A 8 FT #HET 28 106 VAL C 23 2 EPE C B 1 FT #HET 29 107 PHE C 23 2 EPE C A 8 FT #HET 30 108 ARG C 23 2 EPE C A 4 FT #HET 33 111 GLU C 23 2 EPE C S 9 FT #HET 37 115 ASN C 26 5 EDO C A 3 FT #HET 38 116 ARG C 26 5 EDO C S 1 FT #HET 56 134 THR C 25 4 EDO C B 2 FT #HET 57 135 PHE C 25 4 EDO C A 4 FT #HET 58 136 LYS C 25 4 EDO C S 4 FT #HET 70 148 THR C 20 3 EDO C S 1 FT #HET 72 150 GLU C 26 5 EDO C A 5 FT #HET 73 151 ASP C 26 5 EDO C B 3 FT #HET 74 152 HIS C 20 3 EDO C S 5 FT #HET 75 153 TYR C 26 5 EDO C B 4 FT #HET 77 155 ALA C 26 5 EDO C A 3 FT #HET 81 159 TYR C 30 441 JN8 C S 3 FT #HET 84 162 ASN C 26 5 EDO C S 4 FT #HET 86 164 HIS C 22 11 ZN C S 3 FT #HET 97 175 LEU C 24 440 EDO C S 1 FT #HET 100 178 THR C 24 440 EDO C S 5 FT #HET 122 200 HIS C 22 11 ZN C S 3 FT #HET 123 201 ASP C 21 10 ZN C S 3 FT #HET 123 201 ASP C 22 11 ZN C S 3 FT #HET 133 211 PHE C 12 442 EDO A S 1 FT #HET 134 212 LEU C 12 442 EDO A S 1 FT #HET 137 215 THR C 12 442 EDO A S 1 FT #HET 139 217 SER C 12 442 EDO A S 1 FT #HET 146 224 ASN C 38 6 EDO D B 1 FT #HET 147 225 ASP C 38 6 EDO D S 1 FT #HET 147 225 ASP C 41 9 EDO D S 6 FT #HET 148 226 SER C 38 6 EDO D S 1 FT #HET 156 234 LEU C 28 8 EDO C A 2 FT #HET 157 235 ALA C 3 2 EDO A B 1 FT #HET 157 235 ALA C 28 8 EDO C B 2 FT #HET 160 238 PHE C 28 8 EDO C S 4 FT #HET 161 239 LYS C 3 2 EDO A S 3 FT #HET 165 243 GLU C 20 3 EDO C S 7 FT #HET 173 251 ASN C 25 4 EDO C B 2 FT #HET 174 252 LEU C 25 4 EDO C S 1 FT #HET 175 253 THR C 27 7 EDO C A 6 FT #HET 176 254 LYS C 27 7 EDO C A 9 FT #HET 177 255 LYS C 27 7 EDO C A 2 FT #HET 178 256 GLN C 25 4 EDO C S 4 FT #HET 183 261 ARG C 28 8 EDO C S 2 FT #HET 184 262 LYS C 29 9 EDO C A 10 FT #HET 188 266 ASP C 29 9 EDO C S 3 FT #HET 240 318 ASP C 22 11 ZN C S 3 FT #HET 240 318 ASP C 30 441 JN8 C B 2 FT #HET 241 319 LEU C 30 441 JN8 C S 2 FT #HET 243 321 ASN C 30 441 JN8 C S 8 FT #HET 244 322 PRO C 30 441 JN8 C S 3 FT #HET 249 327 GLN C 23 2 EPE C S 1 FT #HET 250 328 LEU C 23 2 EPE C S 3 FT #HET 251 329 TYR C 30 441 JN8 C S 2 FT #HET 253 331 GLN C 23 2 EPE C S 3 FT #HET 255 333 THR C 30 441 JN8 C S 1 FT #HET 258 336 ILE C 30 441 JN8 C S 4 FT #HET 262 340 PHE C 30 441 JN8 C S 6 FT #HET 268 346 ARG C 12 442 EDO A S 1 FT #HET 272 350 ARG C 12 442 EDO A S 3 FT #HET 280 358 CYS C 30 441 JN8 C S 1 FT #HET 290 368 SER C 30 441 JN8 C A 7 FT #HET 291 369 GLN C 30 441 JN8 C S 9 FT #HET 294 372 PHE C 30 441 JN8 C S 16 FT #HET 306 384 TRP C 24 440 EDO C S 1 FT #HET 313 391 ASP C 24 440 EDO C B 4 FT #HET 314 392 ALA C 24 440 EDO C A 2 FT #HET 317 395 ILE C 24 440 EDO C S 2 FT DISORDER 1 7 FT DISORDER 333 361 CC SEQUENCE 325 AA (ATOM); CC TEQEDVLAKE LEDVNKWGLH VFRIAELSGN RPLTVIMHTI FQERDLLKTF KIPVDTLITY CC LMTLEDHYHA DVAYHNNIHA ADVVQSTHVL LSTPALEAVF TDLEILAAIF ASAIHDVDHP CC GVSNQFLINT NSELALMYND SSVLENHHLA VGFKLLQEEN CDIFQNLTKK QRQSLRKMVI CC DIVLATDMSK HMNLLADLKT MVETKKVTSS GVLLLDNYSD RIQVLQNMVH CADLSNPTKP CC LQLYRQWTDR IMEEFFRQGD RERERGMEIS PMCDKHNASV EKSQVGFIDY IVHPLWETWA CC DLVHPDAQDI LDTLEDNREW YQSTI CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES IPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE CC ATOM -------TEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE CC ******************************************* CC SEQRES RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST CC ATOM RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST CC ************************************************** CC SEQRES PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSV CC ATOM PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSV CC ************************************************** CC SEQRES LENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN CC ATOM LENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN CC ************************************************** CC SEQRES LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL CC ATOM LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL CC ************************************************** CC SEQRES YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH CC ATOM YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH CC ************************************************** CC SEQRES PLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQ CC ATOM PLWETWADLVHPDAQDILDTLEDNREWYQSTI------------------ CC ******************************** CC SEQRES TEKFQFELTLE CC ATOM ----------- CC SQ SEQUENCE 361 AA; MW; CN; IPRFGVKTEQ EDVLAKELED VNKWGLHVFR IAELSGNRPL TVIMHTIFQE RDLLKTFKIP VDTLITYLMT LEDHYHADVA YHNNIHAADV VQSTHVLLST PALEAVFTDL EILAAIFASA IHDVDHPGVS NQFLINTNSE LALMYNDSSV LENHHLAVGF KLLQEENCDI FQNLTKKQRQ SLRKMVIDIV LATDMSKHMN LLADLKTMVE TKKVTSSGVL LLDNYSDRIQ VLQNMVHCAD LSNPTKPLQL YRQWTDRIME EFFRQGDRER ERGMEISPMC DKHNASVEKS QVGFIDYIVH PLWETWADLV HPDAQDILDT LEDNREWYQS TIPQSPSPAP DDPEEGRQGQ TEKFQFELTL E // ID 3SL6D STANDARD; PRT; 361 AA. DT CONVERTED FROM PDB (SEQRES) 3SL6 DE cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.440 CC R-Factor 0.201 FT #SUB 161 239 LYS D 161 239 LYS A Protein S 2 FT #SUB 161 239 LYS D 164 242 GLN A Protein S 1 FT #SUB 164 242 GLN D 164 242 GLN A Protein S 7 FT #SUB 166 244 GLU D 176 254 LYS A Protein S 8 FT #SUB 166 244 GLU D 179 257 ARG A Protein S 8 FT #SUB 176 254 LYS D 166 244 GLU A Protein S 7 FT #SUB 179 257 ARG D 166 244 GLU A Protein S 8 FT #SUB 38 116 ARG D 271 349 GLU B Protein S 11 FT #SUB 69 147 MET D 271 349 GLU B Protein S 7 FT #SUB 70 148 THR D 272 350 ARG B Protein S 3 FT #SUB 73 151 ASP D 268 346 ARG B Protein S 8 FT #SUB 73 151 ASP D 272 350 ARG B Protein S 4 FT #SUB 78 156 ASP D 77 155 ALA B Protein S 1 FT #SUB 136 214 ASN D 166 244 GLU B Protein B 2 FT #SUB 137 215 THR D 165 243 GLU B Protein B 4 FT #SUB 137 215 THR D 166 244 GLU B Protein B 6 FT #SUB 138 216 ASN D 164 242 GLN B Protein S 1 FT #SUB 139 217 SER D 165 243 GLU B Protein A 3 FT #SUB 140 218 GLU D 161 239 LYS B Protein S 2 FT #SUB 161 239 LYS D 140 218 GLU B Protein S 4 FT #SUB 165 243 GLU D 137 215 THR B Protein A 7 FT #SUB 165 243 GLU D 138 216 ASN B Protein S 1 FT #SUB 165 243 GLU D 139 217 SER B Protein S 4 FT #SUB 166 244 GLU D 136 214 ASN B Protein S 1 FT #SUB 166 244 GLU D 137 215 THR B Protein B 2 FT #SUB 166 244 GLU D 138 216 ASN B Protein A 7 FT #SUB 268 346 ARG D 73 151 ASP B Protein S 8 FT #SUB 271 349 GLU D 38 116 ARG B Protein S 8 FT #SUB 271 349 GLU D 69 147 MET B Protein S 4 FT #SUB 272 350 ARG D 70 148 THR B Protein S 5 FT #SUB 272 350 ARG D 73 151 ASP B Protein S 3 FT #SUB 142 220 ALA D 183 261 ARG C Protein B 1 FT #SUB 143 221 LEU D 183 261 ARG C Protein S 3 FT #SUB 144 222 MET D 144 222 MET C Protein S 1 FT #SUB 144 222 MET D 145 223 TYR C Protein B 1 FT #SUB 145 223 TYR D 144 222 MET C Protein S 4 FT #SUB 146 224 ASN D 153 231 ASN C Protein S 3 FT #SUB 146 224 ASN D 156 234 LEU C Protein S 1 FT #SUB 146 224 ASN D 183 261 ARG C Protein B 2 FT #SUB 146 224 ASN D 187 265 ILE C Protein S 7 FT #SUB 147 225 ASP D 183 261 ARG C Protein A 4 FT #SUB 153 231 ASN D 146 224 ASN C Protein A 6 FT #SUB 156 234 LEU D 146 224 ASN C Protein S 5 FT #SUB 157 235 ALA D 143 221 LEU C Protein B 1 FT #SUB 157 235 ALA D 146 224 ASN C Protein B 1 FT #SUB 160 238 PHE D 143 221 LEU C Protein S 1 FT #SUB 176 254 LYS D 136 214 ASN C Protein S 3 FT #SUB 176 254 LYS D 138 216 ASN C Protein S 3 FT #SUB 180 258 GLN D 136 214 ASN C Protein S 2 FT #SUB 180 258 GLN D 275 353 GLU C Protein S 1 FT #SUB 183 261 ARG D 142 220 ALA C Protein S 2 FT #SUB 183 261 ARG D 143 221 LEU C Protein S 2 FT #SUB 183 261 ARG D 146 224 ASN C Protein S 1 FT #SUB 183 261 ARG D 147 225 ASP C Protein S 10 FT #SUB 187 265 ILE D 146 224 ASN C Protein S 5 FT #HET 24 102 TRP D 40 8 EDO D A 3 FT #HET 42 120 VAL D 37 5 EDO D S 2 FT #HET 45 123 HIS D 37 5 EDO D S 4 FT #HET 57 135 PHE D 36 4 EDO D S 1 FT #HET 70 148 THR D 31 3 EDO D S 2 FT #HET 74 152 HIS D 31 3 EDO D S 5 FT #HET 78 156 ASP D 43 11 EDO D B 3 FT #HET 79 157 VAL D 43 11 EDO D B 1 FT #HET 80 158 ALA D 43 11 EDO D A 7 FT #HET 81 159 TYR D 44 15 JN8 D S 1 FT #HET 86 164 HIS D 33 13 ZN D S 3 FT #HET 97 175 LEU D 35 440 EDO D S 2 FT #HET 100 178 THR D 35 440 EDO D S 7 FT #HET 101 179 PRO D 39 7 EDO D S 3 FT #HET 104 182 GLU D 34 2 EDO D S 9 FT #HET 108 186 THR D 36 4 EDO D S 2 FT #HET 109 187 ASP D 36 4 EDO D A 6 FT #HET 110 188 LEU D 36 4 EDO D A 4 FT #HET 122 200 HIS D 33 13 ZN D S 3 FT #HET 123 201 ASP D 32 12 ZN D S 3 FT #HET 123 201 ASP D 33 13 ZN D S 3 FT #HET 143 221 LEU D 28 8 EDO C B 4 FT #HET 146 224 ASN D 28 8 EDO C S 5 FT #HET 146 224 ASN D 29 9 EDO C B 2 FT #HET 147 225 ASP D 29 9 EDO C S 1 FT #HET 165 243 GLU D 31 3 EDO D S 9 FT #HET 178 256 GLN D 36 4 EDO D S 2 FT #HET 180 258 GLN D 41 9 EDO D B 2 FT #HET 183 261 ARG D 41 9 EDO D A 3 FT #HET 184 262 LYS D 38 6 EDO D S 5 FT #HET 184 262 LYS D 41 9 EDO D A 11 FT #HET 187 265 ILE D 38 6 EDO D S 1 FT #HET 188 266 ASP D 38 6 EDO D S 4 FT #HET 195 273 MET D 44 15 JN8 D S 3 FT #HET 240 318 ASP D 33 13 ZN D S 3 FT #HET 241 319 LEU D 44 15 JN8 D S 2 FT #HET 243 321 ASN D 44 15 JN8 D S 7 FT #HET 244 322 PRO D 44 15 JN8 D S 4 FT #HET 247 325 PRO D 42 10 EDO D B 2 FT #HET 248 326 LEU D 42 10 EDO D A 2 FT #HET 251 329 TYR D 44 15 JN8 D S 2 FT #HET 255 333 THR D 44 15 JN8 D S 1 FT #HET 258 336 ILE D 44 15 JN8 D S 3 FT #HET 259 337 MET D 44 15 JN8 D S 2 FT #HET 260 338 GLU D 43 11 EDO D S 1 FT #HET 261 339 GLU D 43 11 EDO D A 5 FT #HET 262 340 PHE D 44 15 JN8 D S 6 FT #HET 279 357 MET D 44 15 JN8 D S 5 FT #HET 290 368 SER D 44 15 JN8 D A 8 FT #HET 291 369 GLN D 44 15 JN8 D S 9 FT #HET 294 372 PHE D 44 15 JN8 D S 19 FT #HET 298 376 ILE D 44 15 JN8 D S 2 FT #HET 306 384 TRP D 35 440 EDO D S 1 FT #HET 310 388 VAL D 35 440 EDO D S 1 FT #HET 313 391 ASP D 35 440 EDO D A 3 FT #HET 313 391 ASP D 39 7 EDO D A 7 FT #HET 314 392 ALA D 35 440 EDO D A 2 FT #HET 317 395 ILE D 35 440 EDO D S 2 FT #HET 317 395 ILE D 40 8 EDO D S 3 FT #HET 320 398 THR D 42 10 EDO D S 2 FT #HET 324 402 ASN D 42 10 EDO D S 3 FT DISORDER 1 9 FT DISORDER 334 361 CC SEQUENCE 324 AA (ATOM); CC QEDVLAKELE DVNKWGLHVF RIAELSGNRP LTVIMHTIFQ ERDLLKTFKI PVDTLITYLM CC TLEDHYHADV AYHNNIHAAD VVQSTHVLLS TPALEAVFTD LEILAAIFAS AIHDVDHPGV CC SNQFLINTNS ELALMYNDSS VLENHHLAVG FKLLQEENCD IFQNLTKKQR QSLRKMVIDI CC VLATDMSKHM NLLADLKTMV ETKKVTSSGV LLLDNYSDRI QVLQNMVHCA DLSNPTKPLQ CC LYRQWTDRIM EEFFRQGDRE RERGMEISPM CDKHNASVEK SQVGFIDYIV HPLWETWADL CC VHPDAQDILD TLEDNREWYQ STIP CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES IPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE CC ATOM ---------QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE CC ***************************************** CC SEQRES RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST CC ATOM RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST CC ************************************************** CC SEQRES PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSV CC ATOM PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSV CC ************************************************** CC SEQRES LENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN CC ATOM LENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN CC ************************************************** CC SEQRES LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL CC ATOM LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL CC ************************************************** CC SEQRES YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH CC ATOM YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH CC ************************************************** CC SEQRES PLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQ CC ATOM PLWETWADLVHPDAQDILDTLEDNREWYQSTIP----------------- CC ********************************* CC SEQRES TEKFQFELTLE CC ATOM ----------- CC SQ SEQUENCE 361 AA; MW; CN; IPRFGVKTEQ EDVLAKELED VNKWGLHVFR IAELSGNRPL TVIMHTIFQE RDLLKTFKIP VDTLITYLMT LEDHYHADVA YHNNIHAADV VQSTHVLLST PALEAVFTDL EILAAIFASA IHDVDHPGVS NQFLINTNSE LALMYNDSSV LENHHLAVGF KLLQEENCDI FQNLTKKQRQ SLRKMVIDIV LATDMSKHMN LLADLKTMVE TKKVTSSGVL LLDNYSDRIQ VLQNMVHCAD LSNPTKPLQL YRQWTDRIME EFFRQGDRER ERGMEISPMC DKHNASVEKS QVGFIDYIVH PLWETWADLV HPDAQDILDT LEDNREWYQS TIPQSPSPAP DDPEEGRQGQ TEKFQFELTL E //