ID	3SL4A	STANDARD;	PRT;	361	AA.
DT	CONVERTED FROM PDB (SEQRES) 3SL4
DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	1.900
CC	R-Factor	0.196
FT	#SUB	142	 220 	ALA	A	183	 261 	ARG	B	Protein	B	1
FT	#SUB	143	 221 	LEU	A	183	 261 	ARG	B	Protein	S	4
FT	#SUB	144	 222 	MET	A	144	 222 	MET	B	Protein	S	1
FT	#SUB	144	 222 	MET	A	145	 223 	TYR	B	Protein	B	1
FT	#SUB	145	 223 	TYR	A	144	 222 	MET	B	Protein	S	4
FT	#SUB	146	 224 	ASN	A	153	 231 	ASN	B	Protein	S	2
FT	#SUB	146	 224 	ASN	A	156	 234 	LEU	B	Protein	S	3
FT	#SUB	146	 224 	ASN	A	187	 265 	ILE	B	Protein	S	3
FT	#SUB	147	 225 	ASP	A	183	 261 	ARG	B	Protein	A	4
FT	#SUB	153	 231 	ASN	A	146	 224 	ASN	B	Protein	A	8
FT	#SUB	156	 234 	LEU	A	146	 224 	ASN	B	Protein	A	4
FT	#SUB	157	 235 	ALA	A	143	 221 	LEU	B	Protein	S	1
FT	#SUB	157	 235 	ALA	A	146	 224 	ASN	B	Protein	B	2
FT	#SUB	164	 242 	GLN	A	143	 221 	LEU	B	Protein	S	1
FT	#SUB	176	 254 	LYS	A	136	 214 	ASN	B	Protein	S	3
FT	#SUB	176	 254 	LYS	A	138	 216 	ASN	B	Protein	S	3
FT	#SUB	180	 258 	GLN	A	136	 214 	ASN	B	Protein	S	4
FT	#SUB	183	 261 	ARG	A	142	 220 	ALA	B	Protein	S	2
FT	#SUB	183	 261 	ARG	A	143	 221 	LEU	B	Protein	S	1
FT	#SUB	183	 261 	ARG	A	146	 224 	ASN	B	Protein	S	2
FT	#SUB	183	 261 	ARG	A	147	 225 	ASP	B	Protein	S	12
FT	#SUB	187	 265 	ILE	A	146	 224 	ASN	B	Protein	S	3
FT	#SUB	187	 265 	ILE	A	147	 225 	ASP	B	Protein	S	1
FT	#SUB	38	 116 	ARG	A	271	 349 	GLU	C	Protein	S	10
FT	#SUB	69	 147 	MET	A	271	 349 	GLU	C	Protein	S	5
FT	#SUB	69	 147 	MET	A	272	 350 	ARG	C	Protein	S	1
FT	#SUB	70	 148 	THR	A	272	 350 	ARG	C	Protein	A	4
FT	#SUB	73	 151 	ASP	A	268	 346 	ARG	C	Protein	S	9
FT	#SUB	73	 151 	ASP	A	272	 350 	ARG	C	Protein	S	1
FT	#SUB	78	 156 	ASP	A	76	 154 	HIS	C	Protein	S	1
FT	#SUB	78	 156 	ASP	A	77	 155 	ALA	C	Protein	S	1
FT	#SUB	78	 156 	ASP	A	78	 156 	ASP	C	Protein	S	3
FT	#SUB	136	 214 	ASN	A	166	 244 	GLU	C	Protein	B	2
FT	#SUB	137	 215 	THR	A	165	 243 	GLU	C	Protein	B	4
FT	#SUB	137	 215 	THR	A	166	 244 	GLU	C	Protein	B	6
FT	#SUB	138	 216 	ASN	A	164	 242 	GLN	C	Protein	S	2
FT	#SUB	138	 216 	ASN	A	166	 244 	GLU	C	Protein	S	1
FT	#SUB	139	 217 	SER	A	165	 243 	GLU	C	Protein	A	2
FT	#SUB	140	 218 	GLU	A	161	 239 	LYS	C	Protein	S	1
FT	#SUB	161	 239 	LYS	A	140	 218 	GLU	C	Protein	S	4
FT	#SUB	165	 243 	GLU	A	137	 215 	THR	C	Protein	A	6
FT	#SUB	165	 243 	GLU	A	139	 217 	SER	C	Protein	S	2
FT	#SUB	166	 244 	GLU	A	136	 214 	ASN	C	Protein	S	1
FT	#SUB	166	 244 	GLU	A	137	 215 	THR	C	Protein	A	5
FT	#SUB	166	 244 	GLU	A	138	 216 	ASN	C	Protein	A	6
FT	#SUB	268	 346 	ARG	A	73	 151 	ASP	C	Protein	S	6
FT	#SUB	271	 349 	GLU	A	38	 116 	ARG	C	Protein	S	1
FT	#SUB	271	 349 	GLU	A	69	 147 	MET	C	Protein	S	3
FT	#SUB	272	 350 	ARG	A	66	 144 	THR	C	Protein	S	5
FT	#SUB	272	 350 	ARG	A	70	 148 	THR	C	Protein	S	5
FT	#SUB	272	 350 	ARG	A	165	 243 	GLU	C	Protein	S	4
FT	#SUB	272	 350 	ARG	A	166	 244 	GLU	C	Protein	S	5
FT	#SUB	272	 350 	ARG	A	168	 246 	CYS	C	Protein	S	1
FT	#SUB	161	 239 	LYS	A	161	 239 	LYS	D	Protein	S	3
FT	#SUB	164	 242 	GLN	A	161	 239 	LYS	D	Protein	S	1
FT	#SUB	164	 242 	GLN	A	164	 242 	GLN	D	Protein	S	6
FT	#SUB	166	 244 	GLU	A	176	 254 	LYS	D	Protein	S	7
FT	#SUB	166	 244 	GLU	A	179	 257 	ARG	D	Protein	S	8
FT	#SUB	176	 254 	LYS	A	166	 244 	GLU	D	Protein	S	8
FT	#SUB	179	 257 	ARG	A	166	 244 	GLU	D	Protein	S	8
FT	#HET	27	 105 	HIS	A	22	442 	DMS	A	A	9
FT	#HET	28	 106 	VAL	A	22	442 	DMS	A	B	2
FT	#HET	29	 107 	PHE	A	22	442 	DMS	A	A	5
FT	#HET	30	 108 	ARG	A	22	442 	DMS	A	A	3
FT	#HET	37	 115 	ASN	A	10	440 	PEG	A	A	4
FT	#HET	37	 115 	ASN	A	15	17 	EDO	A	S	6
FT	#HET	38	 116 	ARG	A	10	440 	PEG	A	S	1
FT	#HET	54	 132 	LEU	A	9	11 	EDO	A	A	4
FT	#HET	58	 136 	LYS	A	9	11 	EDO	A	B	4
FT	#HET	59	 137 	ILE	A	9	11 	EDO	A	B	5
FT	#HET	60	 138 	PRO	A	5	6 	DMS	A	S	1
FT	#HET	61	 139 	VAL	A	9	11 	EDO	A	A	2
FT	#HET	62	 140 	ASP	A	5	6 	DMS	A	S	7
FT	#HET	63	 141 	THR	A	5	6 	DMS	A	S	1
FT	#HET	70	 148 	THR	A	23	443 	EDO	A	S	4
FT	#HET	72	 150 	GLU	A	10	440 	PEG	A	A	3
FT	#HET	73	 151 	ASP	A	10	440 	PEG	A	A	9
FT	#HET	74	 152 	HIS	A	23	443 	EDO	A	S	3
FT	#HET	75	 153 	TYR	A	10	440 	PEG	A	B	6
FT	#HET	76	 154 	HIS	A	10	440 	PEG	A	B	1
FT	#HET	77	 155 	ALA	A	15	17 	EDO	A	A	6
FT	#HET	78	 156 	ASP	A	7	9 	EDO	A	B	1
FT	#HET	78	 156 	ASP	A	53	14 	EDO	C	S	1
FT	#HET	79	 157 	VAL	A	7	9 	EDO	A	A	4
FT	#HET	80	 158 	ALA	A	7	9 	EDO	A	A	3
FT	#HET	81	 159 	TYR	A	20	23 	JN4	A	S	4
FT	#HET	82	 160 	HIS	A	18	20 	PO4	A	S	11
FT	#HET	83	 161 	ASN	A	15	17 	EDO	A	S	4
FT	#HET	84	 162 	ASN	A	10	440 	PEG	A	S	1
FT	#HET	84	 162 	ASN	A	15	17 	EDO	A	S	4
FT	#HET	85	 163 	ILE	A	15	17 	EDO	A	S	4
FT	#HET	86	 164 	HIS	A	1	1 	ZN	A	S	3
FT	#HET	86	 164 	HIS	A	18	20 	PO4	A	S	2
FT	#HET	97	 175 	LEU	A	8	10 	EDO	A	S	2
FT	#HET	100	 178 	THR	A	8	10 	EDO	A	S	5
FT	#HET	108	 186 	THR	A	16	18 	EDO	A	S	6
FT	#HET	110	 188 	LEU	A	11	13 	EDO	A	S	2
FT	#HET	110	 188 	LEU	A	16	18 	EDO	A	S	4
FT	#HET	122	 200 	HIS	A	1	1 	ZN	A	S	3
FT	#HET	123	 201 	ASP	A	1	1 	ZN	A	S	3
FT	#HET	123	 201 	ASP	A	2	2 	ZN	A	S	3
FT	#HET	123	 201 	ASP	A	18	20 	PO4	A	S	4
FT	#HET	127	 205 	PRO	A	7	9 	EDO	A	B	1
FT	#HET	133	 211 	PHE	A	6	7 	EDO	A	S	1
FT	#HET	134	 212 	LEU	A	41	8 	EDO	C	S	1
FT	#HET	139	 217 	SER	A	41	8 	EDO	C	S	1
FT	#HET	140	 218 	GLU	A	4	5 	EDO	A	S	7
FT	#HET	140	 218 	GLU	A	14	16 	EDO	A	S	6
FT	#HET	160	 238 	PHE	A	12	14 	EDO	A	S	4
FT	#HET	161	 239 	LYS	A	19	21 	EDO	A	S	5
FT	#HET	164	 242 	GLN	A	19	21 	EDO	A	A	7
FT	#HET	165	 243 	GLU	A	23	443 	EDO	A	S	8
FT	#HET	167	 245 	ASN	A	5	6 	DMS	A	S	3
FT	#HET	171	 249 	PHE	A	12	14 	EDO	A	S	6
FT	#HET	177	 255 	LYS	A	11	13 	EDO	A	B	2
FT	#HET	178	 256 	GLN	A	11	13 	EDO	A	A	3
FT	#HET	179	 257 	ARG	A	12	14 	EDO	A	S	5
FT	#HET	180	 258 	GLN	A	21	441 	EDO	A	S	3
FT	#HET	180	 258 	GLN	A	30	9 	EDO	B	S	2
FT	#HET	181	 259 	SER	A	11	13 	EDO	A	S	4
FT	#HET	181	 259 	SER	A	16	18 	EDO	A	S	1
FT	#HET	183	 261 	ARG	A	12	14 	EDO	A	S	2
FT	#HET	184	 262 	LYS	A	3	4 	EDO	A	S	7
FT	#HET	185	 263 	MET	A	16	18 	EDO	A	S	1
FT	#HET	187	 265 	ILE	A	3	4 	EDO	A	S	1
FT	#HET	188	 266 	ASP	A	3	4 	EDO	A	S	5
FT	#HET	188	 266 	ASP	A	13	15 	EDO	A	B	1
FT	#HET	191	 269 	LEU	A	13	15 	EDO	A	S	1
FT	#HET	195	 273 	MET	A	20	23 	JN4	A	S	1
FT	#HET	197	 275 	LYS	A	13	15 	EDO	A	S	4
FT	#HET	233	 311 	GLN	A	13	15 	EDO	A	S	2
FT	#HET	240	 318 	ASP	A	1	1 	ZN	A	S	3
FT	#HET	240	 318 	ASP	A	18	20 	PO4	A	S	6
FT	#HET	241	 319 	LEU	A	20	23 	JN4	A	S	2
FT	#HET	243	 321 	ASN	A	20	23 	JN4	A	S	5
FT	#HET	244	 322 	PRO	A	20	23 	JN4	A	S	4
FT	#HET	250	 328 	LEU	A	22	442 	DMS	A	S	1
FT	#HET	251	 329 	TYR	A	20	23 	JN4	A	S	2
FT	#HET	252	 330 	ARG	A	17	19 	EDO	A	S	1
FT	#HET	253	 331 	GLN	A	22	442 	DMS	A	S	1
FT	#HET	254	 332 	TRP	A	20	23 	JN4	A	B	2
FT	#HET	255	 333 	THR	A	20	23 	JN4	A	A	3
FT	#HET	258	 336 	ILE	A	20	23 	JN4	A	S	4
FT	#HET	259	 337 	MET	A	20	23 	JN4	A	S	1
FT	#HET	261	 339 	GLU	A	7	9 	EDO	A	A	3
FT	#HET	262	 340 	PHE	A	20	23 	JN4	A	S	1
FT	#HET	264	 342 	ARG	A	7	9 	EDO	A	S	5
FT	#HET	268	 346 	ARG	A	7	9 	EDO	A	S	4
FT	#HET	272	 350 	ARG	A	6	7 	EDO	A	S	6
FT	#HET	279	 357 	MET	A	20	23 	JN4	A	S	3
FT	#HET	287	 365 	VAL	A	17	19 	EDO	A	S	1
FT	#HET	288	 366 	GLU	A	17	19 	EDO	A	S	7
FT	#HET	290	 368 	SER	A	20	23 	JN4	A	A	2
FT	#HET	291	 369 	GLN	A	20	23 	JN4	A	S	9
FT	#HET	294	 372 	PHE	A	20	23 	JN4	A	S	24
FT	#HET	306	 384 	TRP	A	8	10 	EDO	A	S	2
FT	#HET	310	 388 	VAL	A	8	10 	EDO	A	S	1
FT	#HET	313	 391 	ASP	A	8	10 	EDO	A	B	1
FT	#HET	314	 392 	ALA	A	8	10 	EDO	A	S	1
FT	#HET	317	 395 	ILE	A	8	10 	EDO	A	S	2
FT	#HET	327	 405 	TRP	A	17	19 	EDO	A	S	1
FT	#HET	328	 406 	TYR	A	17	19 	EDO	A	S	1
FT	#HET	331	 409 	THR	A	17	19 	EDO	A	S	3
FT	DISORDER	1	4
FT	DISORDER	334	361
CC	SEQUENCE	329 AA (ATOM);
CC	GVKTEQEDVL AKELEDVNKW GLHVFRIAEL SGNRPLTVIM HTIFQERDLL KTFKIPVDTL
CC	ITYLMTLEDH YHADVAYHNN IHAADVVQST HVLLSTPALE AVFTDLEILA AIFASAIHDV
CC	DHPGVSNQFL INTNSELALM YNDSSVLENH HLAVGFKLLQ EENCDIFQNL TKKQRQSLRK
CC	MVIDIVLATD MSKHMNLLAD LKTMVETKKV TSSGVLLLDN YSDRIQVLQN MVHCADLSNP
CC	TKPLQLYRQW TDRIMEEFFR QGDRERERGM EISPMCDKHN ASVEKSQVGF IDYIVHPLWE
CC	TWADLVHPDA QDILDTLEDN REWYQSTIP
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES IPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE
CC	ATOM   ----GVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE
CC	           **********************************************
CC	SEQRES RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
CC	ATOM   RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
CC	       **************************************************
CC	SEQRES PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSV
CC	ATOM   PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSV
CC	       **************************************************
CC	SEQRES LENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN
CC	ATOM   LENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN
CC	       **************************************************
CC	SEQRES LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL
CC	ATOM   LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL
CC	       **************************************************
CC	SEQRES YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH
CC	ATOM   YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH
CC	       **************************************************
CC	SEQRES PLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQ
CC	ATOM   PLWETWADLVHPDAQDILDTLEDNREWYQSTIP-----------------
CC	       *********************************                 
CC	SEQRES TEKFQFELTLE
CC	ATOM   -----------
CC	                  
SQ	SEQUENCE	361 AA;      MW;         CN;
	IPRFGVKTEQ EDVLAKELED VNKWGLHVFR IAELSGNRPL TVIMHTIFQE RDLLKTFKIP
	VDTLITYLMT LEDHYHADVA YHNNIHAADV VQSTHVLLST PALEAVFTDL EILAAIFASA
	IHDVDHPGVS NQFLINTNSE LALMYNDSSV LENHHLAVGF KLLQEENCDI FQNLTKKQRQ
	SLRKMVIDIV LATDMSKHMN LLADLKTMVE TKKVTSSGVL LLDNYSDRIQ VLQNMVHCAD
	LSNPTKPLQL YRQWTDRIME EFFRQGDRER ERGMEISPMC DKHNASVEKS QVGFIDYIVH
	PLWETWADLV HPDAQDILDT LEDNREWYQS TIPQSPSPAP DDPEEGRQGQ TEKFQFELTL
	E
//
ID	3SL4B	STANDARD;	PRT;	361	AA.
DT	CONVERTED FROM PDB (SEQRES) 3SL4
DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	1.900
CC	R-Factor	0.196
FT	#SUB	136	 214 	ASN	B	176	 254 	LYS	A	Protein	B	3
FT	#SUB	136	 214 	ASN	B	180	 258 	GLN	A	Protein	A	4
FT	#SUB	138	 216 	ASN	B	176	 254 	LYS	A	Protein	S	3
FT	#SUB	142	 220 	ALA	B	183	 261 	ARG	A	Protein	B	2
FT	#SUB	143	 221 	LEU	B	157	 235 	ALA	A	Protein	B	1
FT	#SUB	143	 221 	LEU	B	164	 242 	GLN	A	Protein	S	1
FT	#SUB	143	 221 	LEU	B	183	 261 	ARG	A	Protein	B	1
FT	#SUB	144	 222 	MET	B	144	 222 	MET	A	Protein	S	1
FT	#SUB	144	 222 	MET	B	145	 223 	TYR	A	Protein	B	4
FT	#SUB	145	 223 	TYR	B	144	 222 	MET	A	Protein	S	1
FT	#SUB	146	 224 	ASN	B	153	 231 	ASN	A	Protein	S	8
FT	#SUB	146	 224 	ASN	B	156	 234 	LEU	A	Protein	S	4
FT	#SUB	146	 224 	ASN	B	157	 235 	ALA	A	Protein	S	2
FT	#SUB	146	 224 	ASN	B	183	 261 	ARG	A	Protein	B	2
FT	#SUB	146	 224 	ASN	B	187	 265 	ILE	A	Protein	B	3
FT	#SUB	147	 225 	ASP	B	183	 261 	ARG	A	Protein	A	12
FT	#SUB	147	 225 	ASP	B	187	 265 	ILE	A	Protein	S	1
FT	#SUB	153	 231 	ASN	B	146	 224 	ASN	A	Protein	S	2
FT	#SUB	156	 234 	LEU	B	146	 224 	ASN	A	Protein	S	3
FT	#SUB	183	 261 	ARG	B	142	 220 	ALA	A	Protein	S	1
FT	#SUB	183	 261 	ARG	B	143	 221 	LEU	A	Protein	S	4
FT	#SUB	183	 261 	ARG	B	147	 225 	ASP	A	Protein	S	4
FT	#SUB	187	 265 	ILE	B	146	 224 	ASN	A	Protein	S	3
FT	#SUB	161	 239 	LYS	B	161	 239 	LYS	C	Protein	S	1
FT	#SUB	166	 244 	GLU	B	176	 254 	LYS	C	Protein	S	6
FT	#SUB	176	 254 	LYS	B	166	 244 	GLU	C	Protein	S	5
FT	#SUB	38	 116 	ARG	B	271	 349 	GLU	D	Protein	S	9
FT	#SUB	66	 144 	THR	B	272	 350 	ARG	D	Protein	S	1
FT	#SUB	69	 147 	MET	B	271	 349 	GLU	D	Protein	S	5
FT	#SUB	69	 147 	MET	B	272	 350 	ARG	D	Protein	S	3
FT	#SUB	70	 148 	THR	B	272	 350 	ARG	D	Protein	A	4
FT	#SUB	73	 151 	ASP	B	268	 346 	ARG	D	Protein	S	10
FT	#SUB	73	 151 	ASP	B	272	 350 	ARG	D	Protein	S	4
FT	#SUB	77	 155 	ALA	B	78	 156 	ASP	D	Protein	B	1
FT	#SUB	78	 156 	ASP	B	77	 155 	ALA	D	Protein	S	1
FT	#SUB	136	 214 	ASN	B	166	 244 	GLU	D	Protein	B	1
FT	#SUB	137	 215 	THR	B	165	 243 	GLU	D	Protein	A	7
FT	#SUB	137	 215 	THR	B	166	 244 	GLU	D	Protein	B	4
FT	#SUB	138	 216 	ASN	B	165	 243 	GLU	D	Protein	B	1
FT	#SUB	138	 216 	ASN	B	166	 244 	GLU	D	Protein	S	8
FT	#SUB	139	 217 	SER	B	165	 243 	GLU	D	Protein	A	3
FT	#SUB	140	 218 	GLU	B	161	 239 	LYS	D	Protein	S	1
FT	#SUB	161	 239 	LYS	B	140	 218 	GLU	D	Protein	S	3
FT	#SUB	164	 242 	GLN	B	138	 216 	ASN	D	Protein	B	1
FT	#SUB	165	 243 	GLU	B	137	 215 	THR	D	Protein	A	5
FT	#SUB	165	 243 	GLU	B	139	 217 	SER	D	Protein	S	2
FT	#SUB	166	 244 	GLU	B	136	 214 	ASN	D	Protein	S	2
FT	#SUB	166	 244 	GLU	B	137	 215 	THR	D	Protein	A	6
FT	#SUB	268	 346 	ARG	B	73	 151 	ASP	D	Protein	S	4
FT	#SUB	271	 349 	GLU	B	38	 116 	ARG	D	Protein	S	10
FT	#SUB	271	 349 	GLU	B	69	 147 	MET	D	Protein	A	6
FT	#SUB	272	 350 	ARG	B	70	 148 	THR	D	Protein	S	4
FT	#SUB	272	 350 	ARG	B	73	 151 	ASP	D	Protein	S	2
FT	#HET	37	 115 	ASN	B	28	7 	DMS	B	A	2
FT	#HET	37	 115 	ASN	B	33	13 	EDO	B	S	6
FT	#HET	72	 150 	GLU	B	28	7 	DMS	B	A	6
FT	#HET	73	 151 	ASP	B	28	7 	DMS	B	A	5
FT	#HET	75	 153 	TYR	B	28	7 	DMS	B	B	5
FT	#HET	77	 155 	ALA	B	33	13 	EDO	B	A	3
FT	#HET	81	 159 	TYR	B	40	21 	JN4	B	S	6
FT	#HET	82	 160 	HIS	B	39	20 	PO4	B	S	10
FT	#HET	83	 161 	ASN	B	33	13 	EDO	B	S	2
FT	#HET	84	 162 	ASN	B	28	7 	DMS	B	S	4
FT	#HET	84	 162 	ASN	B	33	13 	EDO	B	S	4
FT	#HET	85	 163 	ILE	B	33	13 	EDO	B	S	3
FT	#HET	86	 164 	HIS	B	24	1 	ZN	B	S	3
FT	#HET	86	 164 	HIS	B	39	20 	PO4	B	S	2
FT	#HET	98	 176 	LEU	B	35	16 	EDO	B	B	5
FT	#HET	99	 177 	SER	B	35	16 	EDO	B	B	5
FT	#HET	100	 178 	THR	B	35	16 	EDO	B	B	6
FT	#HET	101	 179 	PRO	B	38	19 	EDO	B	A	2
FT	#HET	102	 180 	ALA	B	37	18 	EDO	B	S	1
FT	#HET	102	 180 	ALA	B	38	19 	EDO	B	A	3
FT	#HET	103	 181 	LEU	B	35	16 	EDO	B	A	6
FT	#HET	104	 182 	GLU	B	35	16 	EDO	B	A	9
FT	#HET	105	 183 	ALA	B	36	17 	EDO	B	B	2
FT	#HET	106	 184 	VAL	B	36	17 	EDO	B	B	2
FT	#HET	107	 185 	PHE	B	36	17 	EDO	B	B	2
FT	#HET	122	 200 	HIS	B	24	1 	ZN	B	S	3
FT	#HET	123	 201 	ASP	B	24	1 	ZN	B	S	3
FT	#HET	123	 201 	ASP	B	25	2 	ZN	B	S	3
FT	#HET	123	 201 	ASP	B	39	20 	PO4	B	S	4
FT	#HET	130	 208 	SER	B	26	4 	EDO	B	S	2
FT	#HET	131	 209 	ASN	B	32	11 	EDO	B	S	2
FT	#HET	132	 210 	GLN	B	21	441 	EDO	A	S	3
FT	#HET	132	 210 	GLN	B	32	11 	EDO	B	A	3
FT	#HET	132	 210 	GLN	B	34	15 	EDO	B	B	2
FT	#HET	133	 211 	PHE	B	34	15 	EDO	B	A	4
FT	#HET	133	 211 	PHE	B	57	5 	EDO	D	S	2
FT	#HET	134	 212 	LEU	B	57	5 	EDO	D	S	1
FT	#HET	135	 213 	ILE	B	32	11 	EDO	B	S	1
FT	#HET	136	 214 	ASN	B	21	441 	EDO	A	S	5
FT	#HET	136	 214 	ASN	B	30	9 	EDO	B	S	7
FT	#HET	136	 214 	ASN	B	34	15 	EDO	B	S	6
FT	#HET	137	 215 	THR	B	57	5 	EDO	D	S	2
FT	#HET	139	 217 	SER	B	57	5 	EDO	D	S	1
FT	#HET	140	 218 	GLU	B	29	8 	EDO	B	S	7
FT	#HET	140	 218 	GLU	B	31	10 	EDO	B	S	5
FT	#HET	148	 226 	SER	B	3	4 	EDO	A	S	1
FT	#HET	195	 273 	MET	B	40	21 	JN4	B	S	3
FT	#HET	212	 290 	LYS	B	27	6 	EPE	B	A	5
FT	#HET	212	 290 	LYS	B	37	18 	EDO	B	S	2
FT	#HET	214	 292 	VAL	B	27	6 	EPE	B	S	2
FT	#HET	240	 318 	ASP	B	24	1 	ZN	B	S	3
FT	#HET	240	 318 	ASP	B	39	20 	PO4	B	S	4
FT	#HET	241	 319 	LEU	B	40	21 	JN4	B	S	2
FT	#HET	243	 321 	ASN	B	40	21 	JN4	B	S	10
FT	#HET	244	 322 	PRO	B	40	21 	JN4	B	S	1
FT	#HET	251	 329 	TYR	B	40	21 	JN4	B	S	2
FT	#HET	254	 332 	TRP	B	40	21 	JN4	B	B	2
FT	#HET	255	 333 	THR	B	40	21 	JN4	B	A	2
FT	#HET	257	 335 	ARG	B	33	13 	EDO	B	S	3
FT	#HET	258	 336 	ILE	B	40	21 	JN4	B	S	7
FT	#HET	259	 337 	MET	B	40	21 	JN4	B	S	1
FT	#HET	262	 340 	PHE	B	26	4 	EDO	B	S	6
FT	#HET	262	 340 	PHE	B	40	21 	JN4	B	S	1
FT	#HET	269	 347 	GLU	B	34	15 	EDO	B	S	6
FT	#HET	271	 349 	GLU	B	66	9 	DMS	D	B	2
FT	#HET	272	 350 	ARG	B	57	5 	EDO	D	S	4
FT	#HET	272	 350 	ARG	B	66	9 	DMS	D	B	4
FT	#HET	274	 352 	MET	B	34	15 	EDO	B	S	4
FT	#HET	275	 353 	GLU	B	34	15 	EDO	B	B	4
FT	#HET	277	 355 	SER	B	34	15 	EDO	B	S	2
FT	#HET	278	 356 	PRO	B	26	4 	EDO	B	B	2
FT	#HET	279	 357 	MET	B	40	21 	JN4	B	S	1
FT	#HET	280	 358 	CYS	B	26	4 	EDO	B	S	1
FT	#HET	290	 368 	SER	B	40	21 	JN4	B	S	1
FT	#HET	291	 369 	GLN	B	40	21 	JN4	B	S	9
FT	#HET	294	 372 	PHE	B	40	21 	JN4	B	S	11
FT	#HET	309	 387 	LEU	B	37	18 	EDO	B	B	2
FT	#HET	310	 388 	VAL	B	37	18 	EDO	B	B	3
FT	#HET	311	 389 	HIS	B	37	18 	EDO	B	A	6
FT	#HET	311	 389 	HIS	B	38	19 	EDO	B	B	4
FT	#HET	312	 390 	PRO	B	38	19 	EDO	B	S	2
FT	#HET	313	 391 	ASP	B	38	19 	EDO	B	S	4
FT	DISORDER	1	9
FT	DISORDER	335	361
CC	SEQUENCE	325 AA (ATOM);
CC	QEDVLAKELE DVNKWGLHVF RIAELSGNRP LTVIMHTIFQ ERDLLKTFKI PVDTLITYLM
CC	TLEDHYHADV AYHNNIHAAD VVQSTHVLLS TPALEAVFTD LEILAAIFAS AIHDVDHPGV
CC	SNQFLINTNS ELALMYNDSS VLENHHLAVG FKLLQEENCD IFQNLTKKQR QSLRKMVIDI
CC	VLATDMSKHM NLLADLKTMV ETKKVTSSGV LLLDNYSDRI QVLQNMVHCA DLSNPTKPLQ
CC	LYRQWTDRIM EEFFRQGDRE RERGMEISPM CDKHNASVEK SQVGFIDYIV HPLWETWADL
CC	VHPDAQDILD TLEDNREWYQ STIPQ
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES IPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE
CC	ATOM   ---------QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE
CC	                *****************************************
CC	SEQRES RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
CC	ATOM   RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
CC	       **************************************************
CC	SEQRES PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSV
CC	ATOM   PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSV
CC	       **************************************************
CC	SEQRES LENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN
CC	ATOM   LENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN
CC	       **************************************************
CC	SEQRES LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL
CC	ATOM   LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL
CC	       **************************************************
CC	SEQRES YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH
CC	ATOM   YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH
CC	       **************************************************
CC	SEQRES PLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQ
CC	ATOM   PLWETWADLVHPDAQDILDTLEDNREWYQSTIPQ----------------
CC	       **********************************                
CC	SEQRES TEKFQFELTLE
CC	ATOM   -----------
CC	                  
SQ	SEQUENCE	361 AA;      MW;         CN;
	IPRFGVKTEQ EDVLAKELED VNKWGLHVFR IAELSGNRPL TVIMHTIFQE RDLLKTFKIP
	VDTLITYLMT LEDHYHADVA YHNNIHAADV VQSTHVLLST PALEAVFTDL EILAAIFASA
	IHDVDHPGVS NQFLINTNSE LALMYNDSSV LENHHLAVGF KLLQEENCDI FQNLTKKQRQ
	SLRKMVIDIV LATDMSKHMN LLADLKTMVE TKKVTSSGVL LLDNYSDRIQ VLQNMVHCAD
	LSNPTKPLQL YRQWTDRIME EFFRQGDRER ERGMEISPMC DKHNASVEKS QVGFIDYIVH
	PLWETWADLV HPDAQDILDT LEDNREWYQS TIPQSPSPAP DDPEEGRQGQ TEKFQFELTL
	E
//
ID	3SL4C	STANDARD;	PRT;	361	AA.
DT	CONVERTED FROM PDB (SEQRES) 3SL4
DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	1.900
CC	R-Factor	0.196
FT	#SUB	38	 116 	ARG	C	271	 349 	GLU	A	Protein	S	1
FT	#SUB	66	 144 	THR	C	272	 350 	ARG	A	Protein	S	5
FT	#SUB	69	 147 	MET	C	271	 349 	GLU	A	Protein	S	3
FT	#SUB	70	 148 	THR	C	272	 350 	ARG	A	Protein	S	5
FT	#SUB	73	 151 	ASP	C	268	 346 	ARG	A	Protein	S	6
FT	#SUB	76	 154 	HIS	C	78	 156 	ASP	A	Protein	B	1
FT	#SUB	77	 155 	ALA	C	78	 156 	ASP	A	Protein	B	1
FT	#SUB	78	 156 	ASP	C	78	 156 	ASP	A	Protein	S	3
FT	#SUB	136	 214 	ASN	C	166	 244 	GLU	A	Protein	B	1
FT	#SUB	137	 215 	THR	C	165	 243 	GLU	A	Protein	A	6
FT	#SUB	137	 215 	THR	C	166	 244 	GLU	A	Protein	B	5
FT	#SUB	138	 216 	ASN	C	166	 244 	GLU	A	Protein	S	6
FT	#SUB	139	 217 	SER	C	165	 243 	GLU	A	Protein	A	2
FT	#SUB	140	 218 	GLU	C	161	 239 	LYS	A	Protein	S	4
FT	#SUB	161	 239 	LYS	C	140	 218 	GLU	A	Protein	S	1
FT	#SUB	164	 242 	GLN	C	138	 216 	ASN	A	Protein	B	2
FT	#SUB	165	 243 	GLU	C	137	 215 	THR	A	Protein	A	4
FT	#SUB	165	 243 	GLU	C	139	 217 	SER	A	Protein	S	2
FT	#SUB	165	 243 	GLU	C	272	 350 	ARG	A	Protein	S	4
FT	#SUB	166	 244 	GLU	C	136	 214 	ASN	A	Protein	S	2
FT	#SUB	166	 244 	GLU	C	137	 215 	THR	A	Protein	A	6
FT	#SUB	166	 244 	GLU	C	138	 216 	ASN	A	Protein	B	1
FT	#SUB	166	 244 	GLU	C	272	 350 	ARG	A	Protein	A	5
FT	#SUB	168	 246 	CYS	C	272	 350 	ARG	A	Protein	S	1
FT	#SUB	268	 346 	ARG	C	73	 151 	ASP	A	Protein	S	9
FT	#SUB	271	 349 	GLU	C	38	 116 	ARG	A	Protein	S	10
FT	#SUB	271	 349 	GLU	C	69	 147 	MET	A	Protein	A	5
FT	#SUB	272	 350 	ARG	C	69	 147 	MET	A	Protein	S	1
FT	#SUB	272	 350 	ARG	C	70	 148 	THR	A	Protein	S	4
FT	#SUB	272	 350 	ARG	C	73	 151 	ASP	A	Protein	S	1
FT	#SUB	161	 239 	LYS	C	161	 239 	LYS	B	Protein	S	1
FT	#SUB	166	 244 	GLU	C	176	 254 	LYS	B	Protein	S	5
FT	#SUB	176	 254 	LYS	C	166	 244 	GLU	B	Protein	S	6
FT	#SUB	136	 214 	ASN	C	176	 254 	LYS	D	Protein	B	3
FT	#SUB	136	 214 	ASN	C	180	 258 	GLN	D	Protein	A	4
FT	#SUB	138	 216 	ASN	C	176	 254 	LYS	D	Protein	S	3
FT	#SUB	142	 220 	ALA	C	183	 261 	ARG	D	Protein	B	2
FT	#SUB	143	 221 	LEU	C	157	 235 	ALA	D	Protein	S	1
FT	#SUB	143	 221 	LEU	C	160	 238 	PHE	D	Protein	S	1
FT	#SUB	143	 221 	LEU	C	183	 261 	ARG	D	Protein	B	1
FT	#SUB	144	 222 	MET	C	145	 223 	TYR	D	Protein	B	4
FT	#SUB	145	 223 	TYR	C	144	 222 	MET	D	Protein	S	1
FT	#SUB	146	 224 	ASN	C	153	 231 	ASN	D	Protein	S	7
FT	#SUB	146	 224 	ASN	C	156	 234 	LEU	D	Protein	S	3
FT	#SUB	146	 224 	ASN	C	157	 235 	ALA	D	Protein	S	1
FT	#SUB	146	 224 	ASN	C	183	 261 	ARG	D	Protein	B	1
FT	#SUB	146	 224 	ASN	C	187	 265 	ILE	D	Protein	B	2
FT	#SUB	147	 225 	ASP	C	183	 261 	ARG	D	Protein	A	12
FT	#SUB	147	 225 	ASP	C	187	 265 	ILE	D	Protein	S	1
FT	#SUB	153	 231 	ASN	C	146	 224 	ASN	D	Protein	S	1
FT	#SUB	183	 261 	ARG	C	142	 220 	ALA	D	Protein	S	1
FT	#SUB	183	 261 	ARG	C	143	 221 	LEU	D	Protein	S	4
FT	#SUB	183	 261 	ARG	C	147	 225 	ASP	D	Protein	S	3
FT	#SUB	187	 265 	ILE	C	146	 224 	ASN	D	Protein	S	4
FT	#HET	27	 105 	HIS	C	47	7 	EPE	C	A	9
FT	#HET	28	 106 	VAL	C	47	7 	EPE	C	B	1
FT	#HET	29	 107 	PHE	C	47	7 	EPE	C	A	5
FT	#HET	30	 108 	ARG	C	47	7 	EPE	C	A	6
FT	#HET	33	 111 	GLU	C	47	7 	EPE	C	S	9
FT	#HET	37	 115 	ASN	C	44	4 	EDO	C	S	6
FT	#HET	37	 115 	ASN	C	53	14 	EDO	C	S	1
FT	#HET	56	 134 	THR	C	45	5 	EDO	C	B	2
FT	#HET	57	 135 	PHE	C	45	5 	EDO	C	A	4
FT	#HET	58	 136 	LYS	C	45	5 	EDO	C	S	5
FT	#HET	70	 148 	THR	C	6	7 	EDO	A	A	6
FT	#HET	70	 148 	THR	C	41	8 	EDO	C	S	1
FT	#HET	72	 150 	GLU	C	53	14 	EDO	C	B	3
FT	#HET	73	 151 	ASP	C	6	7 	EDO	A	S	2
FT	#HET	73	 151 	ASP	C	53	14 	EDO	C	A	7
FT	#HET	74	 152 	HIS	C	14	16 	EDO	A	S	2
FT	#HET	74	 152 	HIS	C	41	8 	EDO	C	S	8
FT	#HET	75	 153 	TYR	C	53	14 	EDO	C	B	5
FT	#HET	76	 154 	HIS	C	54	15 	EDO	C	S	2
FT	#HET	77	 155 	ALA	C	44	4 	EDO	C	A	5
FT	#HET	77	 155 	ALA	C	53	14 	EDO	C	A	2
FT	#HET	78	 156 	ASP	C	52	13 	EDO	C	B	3
FT	#HET	79	 157 	VAL	C	52	13 	EDO	C	A	5
FT	#HET	80	 158 	ALA	C	52	13 	EDO	C	A	4
FT	#HET	81	 159 	TYR	C	56	18 	JN4	C	S	6
FT	#HET	82	 160 	HIS	C	55	17 	PO4	C	S	11
FT	#HET	83	 161 	ASN	C	44	4 	EDO	C	S	1
FT	#HET	84	 162 	ASN	C	44	4 	EDO	C	S	3
FT	#HET	84	 162 	ASN	C	53	14 	EDO	C	S	3
FT	#HET	85	 163 	ILE	C	44	4 	EDO	C	S	3
FT	#HET	86	 164 	HIS	C	42	1 	ZN	C	S	3
FT	#HET	86	 164 	HIS	C	55	17 	PO4	C	S	2
FT	#HET	97	 175 	LEU	C	48	440 	EDO	C	S	2
FT	#HET	100	 178 	THR	C	48	440 	EDO	C	S	6
FT	#HET	110	 188 	LEU	C	46	6 	EDO	C	S	1
FT	#HET	122	 200 	HIS	C	42	1 	ZN	C	S	3
FT	#HET	123	 201 	ASP	C	42	1 	ZN	C	S	3
FT	#HET	123	 201 	ASP	C	43	2 	ZN	C	S	3
FT	#HET	123	 201 	ASP	C	55	17 	PO4	C	S	4
FT	#HET	125	 203 	ASP	C	54	15 	EDO	C	A	8
FT	#HET	126	 204 	HIS	C	55	17 	PO4	C	S	1
FT	#HET	127	 205 	PRO	C	52	13 	EDO	C	B	1
FT	#HET	127	 205 	PRO	C	54	15 	EDO	C	A	6
FT	#HET	133	 211 	PHE	C	23	443 	EDO	A	S	2
FT	#HET	137	 215 	THR	C	23	443 	EDO	A	S	1
FT	#HET	138	 216 	ASN	C	19	21 	EDO	A	B	3
FT	#HET	139	 217 	SER	C	19	21 	EDO	A	B	1
FT	#HET	140	 218 	GLU	C	19	21 	EDO	A	B	2
FT	#HET	141	 219 	LEU	C	54	15 	EDO	C	S	2
FT	#HET	145	 223 	TYR	C	78	21 	EDO	D	S	1
FT	#HET	147	 225 	ASP	C	69	441 	PEG	D	S	5
FT	#HET	148	 226 	SER	C	79	22 	EDO	D	S	3
FT	#HET	153	 231 	ASN	C	77	20 	EDO	D	A	4
FT	#HET	153	 231 	ASN	C	78	21 	EDO	D	S	6
FT	#HET	156	 234 	LEU	C	77	20 	EDO	D	A	4
FT	#HET	157	 235 	ALA	C	4	5 	EDO	A	S	1
FT	#HET	157	 235 	ALA	C	77	20 	EDO	D	B	2
FT	#HET	158	 236 	VAL	C	14	16 	EDO	A	S	2
FT	#HET	160	 238 	PHE	C	77	20 	EDO	D	S	2
FT	#HET	161	 239 	LYS	C	4	5 	EDO	A	S	3
FT	#HET	161	 239 	LYS	C	14	16 	EDO	A	S	2
FT	#HET	165	 243 	GLU	C	6	7 	EDO	A	S	1
FT	#HET	165	 243 	GLU	C	41	8 	EDO	C	S	9
FT	#HET	171	 249 	PHE	C	49	10 	DMS	C	S	1
FT	#HET	173	 251 	ASN	C	45	5 	EDO	C	B	3
FT	#HET	177	 255 	LYS	C	46	6 	EDO	C	A	6
FT	#HET	178	 256 	GLN	C	45	5 	EDO	C	S	4
FT	#HET	178	 256 	GLN	C	46	6 	EDO	C	A	3
FT	#HET	179	 257 	ARG	C	49	10 	DMS	C	A	5
FT	#HET	181	 259 	SER	C	46	6 	EDO	C	S	4
FT	#HET	183	 261 	ARG	C	49	10 	DMS	C	A	3
FT	#HET	183	 261 	ARG	C	77	20 	EDO	D	S	1
FT	#HET	184	 262 	LYS	C	50	11 	EDO	C	S	6
FT	#HET	188	 266 	ASP	C	50	11 	EDO	C	S	5
FT	#HET	188	 266 	ASP	C	51	12 	EDO	C	B	1
FT	#HET	191	 269 	LEU	C	51	12 	EDO	C	B	1
FT	#HET	192	 270 	ALA	C	51	12 	EDO	C	A	3
FT	#HET	195	 273 	MET	C	56	18 	JN4	C	S	1
FT	#HET	197	 275 	LYS	C	51	12 	EDO	C	S	2
FT	#HET	233	 311 	GLN	C	51	12 	EDO	C	S	1
FT	#HET	240	 318 	ASP	C	42	1 	ZN	C	S	3
FT	#HET	240	 318 	ASP	C	55	17 	PO4	C	S	4
FT	#HET	240	 318 	ASP	C	56	18 	JN4	C	B	1
FT	#HET	241	 319 	LEU	C	56	18 	JN4	C	S	2
FT	#HET	243	 321 	ASN	C	56	18 	JN4	C	S	14
FT	#HET	244	 322 	PRO	C	56	18 	JN4	C	S	4
FT	#HET	249	 327 	GLN	C	47	7 	EPE	C	S	3
FT	#HET	250	 328 	LEU	C	47	7 	EPE	C	S	3
FT	#HET	251	 329 	TYR	C	56	18 	JN4	C	S	2
FT	#HET	253	 331 	GLN	C	47	7 	EPE	C	S	4
FT	#HET	254	 332 	TRP	C	56	18 	JN4	C	B	2
FT	#HET	255	 333 	THR	C	56	18 	JN4	C	S	1
FT	#HET	257	 335 	ARG	C	44	4 	EDO	C	S	1
FT	#HET	258	 336 	ILE	C	56	18 	JN4	C	S	5
FT	#HET	259	 337 	MET	C	56	18 	JN4	C	S	1
FT	#HET	261	 339 	GLU	C	52	13 	EDO	C	A	4
FT	#HET	264	 342 	ARG	C	52	13 	EDO	C	S	7
FT	#HET	268	 346 	ARG	C	23	443 	EDO	A	S	1
FT	#HET	272	 350 	ARG	C	23	443 	EDO	A	S	5
FT	#HET	279	 357 	MET	C	56	18 	JN4	C	S	3
FT	#HET	291	 369 	GLN	C	56	18 	JN4	C	S	7
FT	#HET	294	 372 	PHE	C	56	18 	JN4	C	S	22
FT	#HET	306	 384 	TRP	C	48	440 	EDO	C	S	2
FT	#HET	310	 388 	VAL	C	48	440 	EDO	C	S	1
FT	#HET	313	 391 	ASP	C	48	440 	EDO	C	B	3
FT	#HET	314	 392 	ALA	C	48	440 	EDO	C	S	1
FT	#HET	317	 395 	ILE	C	48	440 	EDO	C	S	1
FT	DISORDER	1	7
FT	DISORDER	333	361
CC	SEQUENCE	325 AA (ATOM);
CC	TEQEDVLAKE LEDVNKWGLH VFRIAELSGN RPLTVIMHTI FQERDLLKTF KIPVDTLITY
CC	LMTLEDHYHA DVAYHNNIHA ADVVQSTHVL LSTPALEAVF TDLEILAAIF ASAIHDVDHP
CC	GVSNQFLINT NSELALMYND SSVLENHHLA VGFKLLQEEN CDIFQNLTKK QRQSLRKMVI
CC	DIVLATDMSK HMNLLADLKT MVETKKVTSS GVLLLDNYSD RIQVLQNMVH CADLSNPTKP
CC	LQLYRQWTDR IMEEFFRQGD RERERGMEIS PMCDKHNASV EKSQVGFIDY IVHPLWETWA
CC	DLVHPDAQDI LDTLEDNREW YQSTI
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES IPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE
CC	ATOM   -------TEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE
CC	              *******************************************
CC	SEQRES RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
CC	ATOM   RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
CC	       **************************************************
CC	SEQRES PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSV
CC	ATOM   PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSV
CC	       **************************************************
CC	SEQRES LENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN
CC	ATOM   LENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN
CC	       **************************************************
CC	SEQRES LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL
CC	ATOM   LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL
CC	       **************************************************
CC	SEQRES YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH
CC	ATOM   YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH
CC	       **************************************************
CC	SEQRES PLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQ
CC	ATOM   PLWETWADLVHPDAQDILDTLEDNREWYQSTI------------------
CC	       ********************************                  
CC	SEQRES TEKFQFELTLE
CC	ATOM   -----------
CC	                  
SQ	SEQUENCE	361 AA;      MW;         CN;
	IPRFGVKTEQ EDVLAKELED VNKWGLHVFR IAELSGNRPL TVIMHTIFQE RDLLKTFKIP
	VDTLITYLMT LEDHYHADVA YHNNIHAADV VQSTHVLLST PALEAVFTDL EILAAIFASA
	IHDVDHPGVS NQFLINTNSE LALMYNDSSV LENHHLAVGF KLLQEENCDI FQNLTKKQRQ
	SLRKMVIDIV LATDMSKHMN LLADLKTMVE TKKVTSSGVL LLDNYSDRIQ VLQNMVHCAD
	LSNPTKPLQL YRQWTDRIME EFFRQGDRER ERGMEISPMC DKHNASVEKS QVGFIDYIVH
	PLWETWADLV HPDAQDILDT LEDNREWYQS TIPQSPSPAP DDPEEGRQGQ TEKFQFELTL
	E
//
ID	3SL4D	STANDARD;	PRT;	361	AA.
DT	CONVERTED FROM PDB (SEQRES) 3SL4
DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	1.900
CC	R-Factor	0.196
FT	#SUB	161	 239 	LYS	D	161	 239 	LYS	A	Protein	S	3
FT	#SUB	161	 239 	LYS	D	164	 242 	GLN	A	Protein	S	1
FT	#SUB	164	 242 	GLN	D	164	 242 	GLN	A	Protein	S	6
FT	#SUB	166	 244 	GLU	D	176	 254 	LYS	A	Protein	S	8
FT	#SUB	166	 244 	GLU	D	179	 257 	ARG	A	Protein	S	8
FT	#SUB	176	 254 	LYS	D	166	 244 	GLU	A	Protein	S	7
FT	#SUB	179	 257 	ARG	D	166	 244 	GLU	A	Protein	S	8
FT	#SUB	38	 116 	ARG	D	271	 349 	GLU	B	Protein	S	10
FT	#SUB	69	 147 	MET	D	271	 349 	GLU	B	Protein	S	6
FT	#SUB	70	 148 	THR	D	272	 350 	ARG	B	Protein	A	4
FT	#SUB	73	 151 	ASP	D	268	 346 	ARG	B	Protein	S	4
FT	#SUB	73	 151 	ASP	D	272	 350 	ARG	B	Protein	S	2
FT	#SUB	77	 155 	ALA	D	78	 156 	ASP	B	Protein	S	1
FT	#SUB	78	 156 	ASP	D	77	 155 	ALA	B	Protein	S	1
FT	#SUB	136	 214 	ASN	D	166	 244 	GLU	B	Protein	B	2
FT	#SUB	137	 215 	THR	D	165	 243 	GLU	B	Protein	A	5
FT	#SUB	137	 215 	THR	D	166	 244 	GLU	B	Protein	B	6
FT	#SUB	138	 216 	ASN	D	164	 242 	GLN	B	Protein	S	1
FT	#SUB	139	 217 	SER	D	165	 243 	GLU	B	Protein	A	2
FT	#SUB	140	 218 	GLU	D	161	 239 	LYS	B	Protein	S	3
FT	#SUB	161	 239 	LYS	D	140	 218 	GLU	B	Protein	S	1
FT	#SUB	165	 243 	GLU	D	137	 215 	THR	B	Protein	A	7
FT	#SUB	165	 243 	GLU	D	138	 216 	ASN	B	Protein	S	1
FT	#SUB	165	 243 	GLU	D	139	 217 	SER	B	Protein	S	3
FT	#SUB	166	 244 	GLU	D	136	 214 	ASN	B	Protein	S	1
FT	#SUB	166	 244 	GLU	D	137	 215 	THR	B	Protein	A	4
FT	#SUB	166	 244 	GLU	D	138	 216 	ASN	B	Protein	A	8
FT	#SUB	268	 346 	ARG	D	73	 151 	ASP	B	Protein	S	10
FT	#SUB	271	 349 	GLU	D	38	 116 	ARG	B	Protein	S	9
FT	#SUB	271	 349 	GLU	D	69	 147 	MET	B	Protein	A	5
FT	#SUB	272	 350 	ARG	D	66	 144 	THR	B	Protein	S	1
FT	#SUB	272	 350 	ARG	D	69	 147 	MET	B	Protein	A	3
FT	#SUB	272	 350 	ARG	D	70	 148 	THR	B	Protein	S	4
FT	#SUB	272	 350 	ARG	D	73	 151 	ASP	B	Protein	S	4
FT	#SUB	142	 220 	ALA	D	183	 261 	ARG	C	Protein	B	1
FT	#SUB	143	 221 	LEU	D	183	 261 	ARG	C	Protein	S	4
FT	#SUB	144	 222 	MET	D	145	 223 	TYR	C	Protein	B	1
FT	#SUB	145	 223 	TYR	D	144	 222 	MET	C	Protein	S	4
FT	#SUB	146	 224 	ASN	D	153	 231 	ASN	C	Protein	S	1
FT	#SUB	146	 224 	ASN	D	187	 265 	ILE	C	Protein	S	4
FT	#SUB	147	 225 	ASP	D	183	 261 	ARG	C	Protein	S	3
FT	#SUB	153	 231 	ASN	D	146	 224 	ASN	C	Protein	A	7
FT	#SUB	156	 234 	LEU	D	146	 224 	ASN	C	Protein	S	3
FT	#SUB	157	 235 	ALA	D	143	 221 	LEU	C	Protein	B	1
FT	#SUB	157	 235 	ALA	D	146	 224 	ASN	C	Protein	B	1
FT	#SUB	160	 238 	PHE	D	143	 221 	LEU	C	Protein	S	1
FT	#SUB	176	 254 	LYS	D	136	 214 	ASN	C	Protein	S	3
FT	#SUB	176	 254 	LYS	D	138	 216 	ASN	C	Protein	S	3
FT	#SUB	180	 258 	GLN	D	136	 214 	ASN	C	Protein	S	4
FT	#SUB	183	 261 	ARG	D	142	 220 	ALA	C	Protein	S	2
FT	#SUB	183	 261 	ARG	D	143	 221 	LEU	C	Protein	S	1
FT	#SUB	183	 261 	ARG	D	146	 224 	ASN	C	Protein	S	1
FT	#SUB	183	 261 	ARG	D	147	 225 	ASP	C	Protein	S	12
FT	#SUB	187	 265 	ILE	D	146	 224 	ASN	C	Protein	S	2
FT	#SUB	187	 265 	ILE	D	147	 225 	ASP	C	Protein	S	1
FT	#HET	22	 100 	ASN	D	58	12 	PEG	D	B	1
FT	#HET	22	 100 	ASN	D	75	18 	EDO	D	S	6
FT	#HET	23	 101 	LYS	D	58	12 	PEG	D	A	4
FT	#HET	24	 102 	TRP	D	58	12 	PEG	D	A	6
FT	#HET	27	 105 	HIS	D	80	23 	DMS	D	A	11
FT	#HET	28	 106 	VAL	D	80	23 	DMS	D	B	2
FT	#HET	29	 107 	PHE	D	80	23 	DMS	D	A	5
FT	#HET	30	 108 	ARG	D	80	23 	DMS	D	A	3
FT	#HET	32	 110 	ALA	D	63	6 	EDO	D	A	4
FT	#HET	33	 111 	GLU	D	63	6 	EDO	D	A	2
FT	#HET	37	 115 	ASN	D	63	6 	EDO	D	A	4
FT	#HET	37	 115 	ASN	D	70	13 	DMS	D	A	3
FT	#HET	37	 115 	ASN	D	74	17 	EDO	D	S	8
FT	#HET	42	 120 	VAL	D	67	10 	EDO	D	S	2
FT	#HET	45	 123 	HIS	D	67	10 	EDO	D	S	3
FT	#HET	50	 128 	GLU	D	75	18 	EDO	D	S	5
FT	#HET	51	 129 	ARG	D	75	18 	EDO	D	S	3
FT	#HET	62	 140 	ASP	D	66	9 	DMS	D	A	7
FT	#HET	65	 143 	ILE	D	66	9 	DMS	D	S	4
FT	#HET	66	 144 	THR	D	66	9 	DMS	D	S	1
FT	#HET	70	 148 	THR	D	57	5 	EDO	D	S	1
FT	#HET	72	 150 	GLU	D	70	13 	DMS	D	A	6
FT	#HET	73	 151 	ASP	D	70	13 	DMS	D	B	3
FT	#HET	74	 152 	HIS	D	31	10 	EDO	B	S	2
FT	#HET	74	 152 	HIS	D	57	5 	EDO	D	S	3
FT	#HET	75	 153 	TYR	D	70	13 	DMS	D	A	6
FT	#HET	77	 155 	ALA	D	74	17 	EDO	D	A	5
FT	#HET	78	 156 	ASP	D	76	19 	PEG	D	B	2
FT	#HET	79	 157 	VAL	D	76	19 	PEG	D	B	5
FT	#HET	80	 158 	ALA	D	76	19 	PEG	D	A	4
FT	#HET	81	 159 	TYR	D	82	442 	JN4	D	S	6
FT	#HET	82	 160 	HIS	D	81	24 	PO4	D	S	11
FT	#HET	83	 161 	ASN	D	74	17 	EDO	D	S	2
FT	#HET	84	 162 	ASN	D	70	13 	DMS	D	S	5
FT	#HET	84	 162 	ASN	D	74	17 	EDO	D	S	6
FT	#HET	85	 163 	ILE	D	74	17 	EDO	D	S	3
FT	#HET	86	 164 	HIS	D	59	1 	ZN	D	S	3
FT	#HET	86	 164 	HIS	D	81	24 	PO4	D	S	2
FT	#HET	95	 173 	HIS	D	75	18 	EDO	D	S	4
FT	#HET	96	 174 	VAL	D	58	12 	PEG	D	S	1
FT	#HET	96	 174 	VAL	D	64	7 	EDO	D	S	1
FT	#HET	97	 175 	LEU	D	64	7 	EDO	D	S	1
FT	#HET	99	 177 	SER	D	65	8 	DMS	D	B	3
FT	#HET	99	 177 	SER	D	75	18 	EDO	D	S	2
FT	#HET	100	 178 	THR	D	64	7 	EDO	D	S	7
FT	#HET	100	 178 	THR	D	65	8 	DMS	D	B	2
FT	#HET	101	 179 	PRO	D	61	4 	EDO	D	S	3
FT	#HET	101	 179 	PRO	D	65	8 	DMS	D	B	2
FT	#HET	103	 181 	LEU	D	62	440 	EDO	D	B	4
FT	#HET	104	 182 	GLU	D	62	440 	EDO	D	B	2
FT	#HET	104	 182 	GLU	D	65	8 	DMS	D	S	6
FT	#HET	105	 183 	ALA	D	62	440 	EDO	D	B	7
FT	#HET	106	 184 	VAL	D	62	440 	EDO	D	B	4
FT	#HET	107	 185 	PHE	D	62	440 	EDO	D	A	7
FT	#HET	122	 200 	HIS	D	59	1 	ZN	D	S	3
FT	#HET	123	 201 	ASP	D	59	1 	ZN	D	S	3
FT	#HET	123	 201 	ASP	D	60	2 	ZN	D	S	3
FT	#HET	123	 201 	ASP	D	81	24 	PO4	D	S	4
FT	#HET	127	 205 	PRO	D	76	19 	PEG	D	B	2
FT	#HET	143	 221 	LEU	D	77	20 	EDO	D	B	2
FT	#HET	144	 222 	MET	D	77	20 	EDO	D	B	1
FT	#HET	144	 222 	MET	D	78	21 	EDO	D	B	1
FT	#HET	145	 223 	TYR	D	78	21 	EDO	D	A	8
FT	#HET	146	 224 	ASN	D	50	11 	EDO	C	B	2
FT	#HET	146	 224 	ASN	D	77	20 	EDO	D	S	8
FT	#HET	146	 224 	ASN	D	78	21 	EDO	D	S	1
FT	#HET	147	 225 	ASP	D	50	11 	EDO	C	S	2
FT	#HET	148	 226 	SER	D	78	21 	EDO	D	A	2
FT	#HET	148	 226 	SER	D	79	22 	EDO	D	B	1
FT	#HET	149	 227 	SER	D	79	22 	EDO	D	S	1
FT	#HET	153	 231 	ASN	D	78	21 	EDO	D	S	1
FT	#HET	153	 231 	ASN	D	79	22 	EDO	D	S	7
FT	#HET	158	 236 	VAL	D	29	8 	EDO	B	S	1
FT	#HET	158	 236 	VAL	D	31	10 	EDO	B	S	2
FT	#HET	161	 239 	LYS	D	19	21 	EDO	A	S	2
FT	#HET	161	 239 	LYS	D	29	8 	EDO	B	S	1
FT	#HET	161	 239 	LYS	D	31	10 	EDO	B	S	1
FT	#HET	164	 242 	GLN	D	19	21 	EDO	A	S	7
FT	#HET	165	 243 	GLU	D	57	5 	EDO	D	S	8
FT	#HET	180	 258 	GLN	D	69	441 	PEG	D	B	1
FT	#HET	184	 262 	LYS	D	69	441 	PEG	D	A	18
FT	#HET	187	 265 	ILE	D	69	441 	PEG	D	S	2
FT	#HET	188	 266 	ASP	D	68	11 	EDO	D	S	6
FT	#HET	188	 266 	ASP	D	69	441 	PEG	D	S	4
FT	#HET	188	 266 	ASP	D	71	14 	EDO	D	B	1
FT	#HET	191	 269 	LEU	D	71	14 	EDO	D	S	1
FT	#HET	191	 269 	LEU	D	79	22 	EDO	D	S	1
FT	#HET	192	 270 	ALA	D	71	14 	EDO	D	B	1
FT	#HET	195	 273 	MET	D	82	442 	JN4	D	S	3
FT	#HET	197	 275 	LYS	D	71	14 	EDO	D	S	4
FT	#HET	208	 286 	MET	D	72	15 	EDO	D	A	6
FT	#HET	211	 289 	THR	D	72	15 	EDO	D	A	3
FT	#HET	212	 290 	LYS	D	72	15 	EDO	D	B	1
FT	#HET	213	 291 	LYS	D	72	15 	EDO	D	A	6
FT	#HET	220	 298 	LEU	D	72	15 	EDO	D	S	1
FT	#HET	221	 299 	LEU	D	72	15 	EDO	D	B	3
FT	#HET	225	 303 	TYR	D	68	11 	EDO	D	S	1
FT	#HET	229	 307 	ILE	D	68	11 	EDO	D	S	1
FT	#HET	233	 311 	GLN	D	68	11 	EDO	D	S	2
FT	#HET	233	 311 	GLN	D	71	14 	EDO	D	S	2
FT	#HET	240	 318 	ASP	D	59	1 	ZN	D	S	3
FT	#HET	240	 318 	ASP	D	81	24 	PO4	D	S	4
FT	#HET	241	 319 	LEU	D	82	442 	JN4	D	S	2
FT	#HET	243	 321 	ASN	D	82	442 	JN4	D	S	6
FT	#HET	244	 322 	PRO	D	82	442 	JN4	D	S	2
FT	#HET	247	 325 	PRO	D	73	16 	PEG	D	A	5
FT	#HET	248	 326 	LEU	D	73	16 	PEG	D	A	3
FT	#HET	249	 327 	GLN	D	80	23 	DMS	D	S	5
FT	#HET	250	 328 	LEU	D	80	23 	DMS	D	S	2
FT	#HET	251	 329 	TYR	D	82	442 	JN4	D	S	2
FT	#HET	253	 331 	GLN	D	80	23 	DMS	D	S	2
FT	#HET	254	 332 	TRP	D	82	442 	JN4	D	B	2
FT	#HET	255	 333 	THR	D	82	442 	JN4	D	A	2
FT	#HET	258	 336 	ILE	D	82	442 	JN4	D	S	5
FT	#HET	259	 337 	MET	D	82	442 	JN4	D	S	1
FT	#HET	261	 339 	GLU	D	76	19 	PEG	D	A	3
FT	#HET	262	 340 	PHE	D	82	442 	JN4	D	S	4
FT	#HET	264	 342 	ARG	D	76	19 	PEG	D	S	1
FT	#HET	268	 346 	ARG	D	76	19 	PEG	D	S	4
FT	#HET	279	 357 	MET	D	82	442 	JN4	D	S	4
FT	#HET	290	 368 	SER	D	82	442 	JN4	D	S	1
FT	#HET	291	 369 	GLN	D	82	442 	JN4	D	S	8
FT	#HET	294	 372 	PHE	D	82	442 	JN4	D	S	15
FT	#HET	306	 384 	TRP	D	64	7 	EDO	D	S	1
FT	#HET	310	 388 	VAL	D	64	7 	EDO	D	S	1
FT	#HET	313	 391 	ASP	D	61	4 	EDO	D	A	6
FT	#HET	313	 391 	ASP	D	64	7 	EDO	D	A	3
FT	#HET	314	 392 	ALA	D	64	7 	EDO	D	S	1
FT	#HET	316	 394 	ASP	D	58	12 	PEG	D	S	1
FT	#HET	317	 395 	ILE	D	58	12 	PEG	D	S	3
FT	#HET	317	 395 	ILE	D	64	7 	EDO	D	S	2
FT	#HET	320	 398 	THR	D	73	16 	PEG	D	S	1
FT	#HET	323	 401 	ASP	D	73	16 	PEG	D	S	6
FT	#HET	324	 402 	ASN	D	73	16 	PEG	D	S	2
FT	DISORDER	1	9
FT	DISORDER	334	361
CC	SEQUENCE	324 AA (ATOM);
CC	QEDVLAKELE DVNKWGLHVF RIAELSGNRP LTVIMHTIFQ ERDLLKTFKI PVDTLITYLM
CC	TLEDHYHADV AYHNNIHAAD VVQSTHVLLS TPALEAVFTD LEILAAIFAS AIHDVDHPGV
CC	SNQFLINTNS ELALMYNDSS VLENHHLAVG FKLLQEENCD IFQNLTKKQR QSLRKMVIDI
CC	VLATDMSKHM NLLADLKTMV ETKKVTSSGV LLLDNYSDRI QVLQNMVHCA DLSNPTKPLQ
CC	LYRQWTDRIM EEFFRQGDRE RERGMEISPM CDKHNASVEK SQVGFIDYIV HPLWETWADL
CC	VHPDAQDILD TLEDNREWYQ STIP
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES IPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE
CC	ATOM   ---------QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE
CC	                *****************************************
CC	SEQRES RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
CC	ATOM   RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
CC	       **************************************************
CC	SEQRES PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSV
CC	ATOM   PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSV
CC	       **************************************************
CC	SEQRES LENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN
CC	ATOM   LENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMN
CC	       **************************************************
CC	SEQRES LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL
CC	ATOM   LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL
CC	       **************************************************
CC	SEQRES YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH
CC	ATOM   YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVH
CC	       **************************************************
CC	SEQRES PLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQ
CC	ATOM   PLWETWADLVHPDAQDILDTLEDNREWYQSTIP-----------------
CC	       *********************************                 
CC	SEQRES TEKFQFELTLE
CC	ATOM   -----------
CC	                  
SQ	SEQUENCE	361 AA;      MW;         CN;
	IPRFGVKTEQ EDVLAKELED VNKWGLHVFR IAELSGNRPL TVIMHTIFQE RDLLKTFKIP
	VDTLITYLMT LEDHYHADVA YHNNIHAADV VQSTHVLLST PALEAVFTDL EILAAIFASA
	IHDVDHPGVS NQFLINTNSE LALMYNDSSV LENHHLAVGF KLLQEENCDI FQNLTKKQRQ
	SLRKMVIDIV LATDMSKHMN LLADLKTMVE TKKVTSSGVL LLDNYSDRIQ VLQNMVHCAD
	LSNPTKPLQL YRQWTDRIME EFFRQGDRER ERGMEISPMC DKHNASVEKS QVGFIDYIVH
	PLWETWADLV HPDAQDILDT LEDNREWYQS TIPQSPSPAP DDPEEGRQGQ TEKFQFELTL
	E
//