ID	3R7RA	STANDARD;	PRT;	966	AA.
DT	CONVERTED FROM PDB (SEQRES) 3R7R
DE	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isof
DE	orm
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.900
CC	R-Factor	0.209
FT	#HET	662	 804 	MET	A	1	1 	FAZ	A	S	1
FT	#HET	670	 812 	TRP	A	1	1 	FAZ	A	S	7
FT	#HET	689	 831 	ILE	A	1	1 	FAZ	A	S	3
FT	#HET	691	 833 	LYS	A	1	1 	FAZ	A	S	4
FT	#HET	725	 867 	TYR	A	1	1 	FAZ	A	S	4
FT	#HET	737	 879 	ILE	A	1	1 	FAZ	A	S	1
FT	#HET	738	 880 	GLU	A	1	1 	FAZ	A	B	4
FT	#HET	739	 881 	ILE	A	1	1 	FAZ	A	B	2
FT	#HET	740	 882 	VAL	A	1	1 	FAZ	A	A	6
FT	#HET	743	 885 	ALA	A	1	1 	FAZ	A	B	4
FT	#HET	811	 953 	MET	A	1	1 	FAZ	A	S	10
FT	#HET	819	 961 	PHE	A	1	1 	FAZ	A	S	1
FT	#HET	821	 963 	ILE	A	1	1 	FAZ	A	S	10
FT	#HET	822	 964 	ASP	A	1	1 	FAZ	A	A	10
FT	DISORDER	112	124
FT	DISORDER	181	214
FT	DISORDER	294	317
FT	DISORDER	348	354
FT	DISORDER	381	382
FT	DISORDER	386	403
FT	DISORDER	826	838
FT	DISORDER	950	966
CC	Miss-SC	1
CC	SEQUENCE	838 AA (ATOM);
CC	MSEESQAFQR QLTALIGYDV TDVSNVHDDE LEFTRRGLVT PRMAEVASRD PKLYAMHPWV
CC	TSKPLPEYLW KKIANNCIFI VIHRSTTSQT IKVSPDDTPG AILQSFFTKM AEQDFVLRVC
CC	GRDEYLVGET PIKNFQWVRH CLKNGEEIHV VLDTPPDPAL DEVRKEECDR KFRVKIRGID
CC	IPVLPRNTDL TVFVEANIQH GQQVLCQRRT SPKPFTEEVL WNVWLEFSIK IKDLPKGALL
CC	NLQIYCLLYY VNLLLIDHRF LLRRGEYVLH MWQISGFNAD KLTSATNPDK ENSMSISILL
CC	DNHPIEMPNQ LRKQLEAIIA TDPLNPLTAE DKELLWHFRY ESLKHPKAYP KLFSSVKWGQ
CC	QEIVAKTYQL LARREVWDQS ALDVGLTMQL LDCNFSDENV RAIAVQKLES LEDDDVLHYL
CC	LQLVQAVKFE PYHDSALARF LLKRGLRNKR IGHFLFWFLR SEIAQSRHYQ QRFAVILEAY
CC	LRGCGTAMLH DFTQQVQVIE MLQKVTLDIK SLSAEKYDVS SQVISQLKQK LENLQNSQLP
CC	ESFRVPYDPG LKAGALAIEK CKVMASKKKP LWLEFKCADP TALSNETIGI IFKHGDDLRQ
CC	DMLILQILRI MESIWETESL DLCLLPYGCI STGDKIGMIE IVKDATTIAK IQQSTVGNTG
CC	AFKDEVLNHW LKEKSPTEEK FQAAVERFVY SCAGYCVATF VLGIGDRHND NIMITETGNL
CC	FHIDFGHERV PFVLTPDFLF VMGTSGKKTS PHFQKFQDIC VKAYLALRHH TNLLIILFSM
CC	MLMTGMPQLT SKEDIEYIRD ALTVGKNEED AKKYFLDQIE VCRDKGWTVQ FNWFLHLV
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRD
CC	ATOM   MSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRD
CC	       **************************************************
CC	SEQRES PKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPG
CC	ATOM   PKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPG
CC	       **************************************************
CC	SEQRES AILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQW
CC	ATOM   AILQSFFTKMA-------------EQDFVLRVCGRDEYLVGETPIKNFQW
CC	       ***********             **************************
CC	SEQRES VRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIH
CC	ATOM   VRHCLKNGEEIHVVLDTPPDPALDEVRKEE--------------------
CC	       ******************************                    
CC	SEQRES GKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQ
CC	ATOM   --------------CDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQ
CC	                     ************************************
CC	SEQRES VLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALS
CC	ATOM   VLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYC-------
CC	       *******************************************       
CC	SEQRES SKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGE
CC	ATOM   -----------------LLYYVNLLLIDHRFLLRRGEYVLHMWQISG---
CC	                        ******************************   
CC	SEQRES DQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDR
CC	ATOM   ----FNADKLTSATNPDKENSMSISILLDN--HPI---------------
CC	           **************************  ***               
CC	SEQRES VRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKL
CC	ATOM   ---EMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKL
CC	          ***********************************************
CC	SEQRES FSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRA
CC	ATOM   FSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRA
CC	       **************************************************
CC	SEQRES IAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIG
CC	ATOM   IAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIG
CC	       **************************************************
CC	SEQRES HFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEML
CC	ATOM   HFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEML
CC	       **************************************************
CC	SEQRES QKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLK
CC	ATOM   QKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLK
CC	       **************************************************
CC	SEQRES AGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDM
CC	ATOM   AGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDM
CC	       **************************************************
CC	SEQRES LILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQ
CC	ATOM   LILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQ
CC	       **************************************************
CC	SEQRES QSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVL
CC	ATOM   QSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVL
CC	       **************************************************
CC	SEQRES GIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFL
CC	ATOM   GIGDRHNDNIMITETGNLFHIDFGH-------------ERVPFVLTPDFL
CC	       *************************             ************
CC	SEQRES FVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQL
CC	ATOM   FVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQL
CC	       **************************************************
CC	SEQRES TSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVL
CC	ATOM   TSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLV-
CC	       ************************************************* 
CC	SEQRES GIKQGEKHSAHHHHHH
CC	ATOM   ----------------
CC	                       
SQ	SEQUENCE	966 AA;      MW;         CN;
	MSEESQAFQR QLTALIGYDV TDVSNVHDDE LEFTRRGLVT PRMAEVASRD PKLYAMHPWV
	TSKPLPEYLW KKIANNCIFI VIHRSTTSQT IKVSPDDTPG AILQSFFTKM AKKKSLMDIP
	ESQSEQDFVL RVCGRDEYLV GETPIKNFQW VRHCLKNGEE IHVVLDTPPD PALDEVRKEE
	WPLVDDCTGV TGYHEQLTIH GKDHESVFTV SLWDCDRKFR VKIRGIDIPV LPRNTDLTVF
	VEANIQHGQQ VLCQRRTSPK PFTEEVLWNV WLEFSIKIKD LPKGALLNLQ IYCGKAPALS
	SKASAESPSS ESKGKVQLLY YVNLLLIDHR FLLRRGEYVL HMWQISGKGE DQGSFNADKL
	TSATNPDKEN SMSISILLDN YCHPIALPKH QPTPDPEGDR VRAEMPNQLR KQLEAIIATD
	PLNPLTAEDK ELLWHFRYES LKHPKAYPKL FSSVKWGQQE IVAKTYQLLA RREVWDQSAL
	DVGLTMQLLD CNFSDENVRA IAVQKLESLE DDDVLHYLLQ LVQAVKFEPY HDSALARFLL
	KRGLRNKRIG HFLFWFLRSE IAQSRHYQQR FAVILEAYLR GCGTAMLHDF TQQVQVIEML
	QKVTLDIKSL SAEKYDVSSQ VISQLKQKLE NLQNSQLPES FRVPYDPGLK AGALAIEKCK
	VMASKKKPLW LEFKCADPTA LSNETIGIIF KHGDDLRQDM LILQILRIME SIWETESLDL
	CLLPYGCIST GDKIGMIEIV KDATTIAKIQ QSTVGNTGAF KDEVLNHWLK EKSPTEEKFQ
	AAVERFVYSC AGYCVATFVL GIGDRHNDNI MITETGNLFH IDFGHILGNY KSFLGINKER
	VPFVLTPDFL FVMGTSGKKT SPHFQKFQDI CVKAYLALRH HTNLLIILFS MMLMTGMPQL
	TSKEDIEYIR DALTVGKNEE DAKKYFLDQI EVCRDKGWTV QFNWFLHLVL GIKQGEKHSA
	HHHHHH
//