ID	3Q32A	STANDARD;	PRT;	301	AA.
DT	CONVERTED FROM PDB (SEQRES) 3Q32
DE	Tyrosine-protein kinase JAK2
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.500
CC	R-Factor	0.178
FT	#SUB	108	 945 	LYS	A	272	1109 	ASN	B	Protein	A	4
FT	#SUB	108	 945 	LYS	A	274	1111 	ASN	B	Protein	B	3
FT	#SUB	109	 946 	GLU	A	274	1111 	ASN	B	Protein	B	3
FT	#SUB	110	 947 	ARG	A	274	1111 	ASN	B	Protein	B	1
FT	#SUB	111	 948 	ILE	A	274	1111 	ASN	B	Protein	B	6
FT	#SUB	112	 949 	ASP	A	274	1111 	ASN	B	Protein	A	2
FT	#SUB	113	 950 	HIS	A	274	1111 	ASN	B	Protein	S	3
FT	#SUB	211	1048 	PHE	A	275	1112 	GLN	B	Protein	B	2
FT	#SUB	212	1049 	THR	A	275	1112 	GLN	B	Protein	B	4
FT	#SUB	213	1050 	TYR	A	272	1109 	ASN	B	Protein	S	4
FT	#SUB	213	1050 	TYR	A	274	1111 	ASN	B	Protein	S	3
FT	#SUB	213	1050 	TYR	A	275	1112 	GLN	B	Protein	S	4
FT	#SUB	215	1052 	GLU	A	275	1112 	GLN	B	Protein	S	1
FT	#SUB	253	1090 	ARG	A	267	1104 	GLU	B	Protein	S	9
FT	#SUB	253	1090 	ARG	A	285	1122 	ARG	B	Protein	S	12
FT	#SUB	255	1092 	ASP	A	267	1104 	GLU	B	Protein	A	4
FT	#SUB	255	1092 	ASP	A	270	1107 	ASN	B	Protein	S	2
FT	#SUB	255	1092 	ASP	A	275	1112 	GLN	B	Protein	A	5
FT	#SUB	256	1093 	GLY	A	267	1104 	GLU	B	Protein	B	4
FT	#SUB	256	1093 	GLY	A	275	1112 	GLN	B	Protein	B	3
FT	#SUB	256	1093 	GLY	A	276	1113 	ARG	B	Protein	B	1
FT	#SUB	256	1093 	GLY	A	277	1114 	PRO	B	Protein	B	2
FT	#SUB	256	1093 	GLY	A	281	1118 	ASP	B	Protein	B	1
FT	#SUB	257	1094 	CYS	A	285	1122 	ARG	B	Protein	B	1
FT	#SUB	258	1095 	PRO	A	281	1118 	ASP	B	Protein	A	7
FT	#SUB	259	1096 	ASP	A	288	1125 	GLN	B	Protein	S	2
FT	#HET	18	 855 	LEU	A	1	1 	J2I	A	A	12
FT	#HET	19	 856 	GLY	A	1	1 	J2I	A	B	6
FT	#HET	20	 857 	LYS	A	1	1 	J2I	A	B	7
FT	#HET	24	 861 	GLY	A	1	1 	J2I	A	B	2
FT	#HET	25	 862 	SER	A	1	1 	J2I	A	B	4
FT	#HET	26	 863 	VAL	A	1	1 	J2I	A	A	4
FT	#HET	43	 880 	ALA	A	1	1 	J2I	A	S	4
FT	#HET	45	 882 	LYS	A	1	1 	J2I	A	S	1
FT	#HET	92	 929 	MET	A	1	1 	J2I	A	S	2
FT	#HET	93	 930 	GLU	A	1	1 	J2I	A	B	2
FT	#HET	94	 931 	TYR	A	1	1 	J2I	A	A	7
FT	#HET	95	 932 	LEU	A	1	1 	J2I	A	B	10
FT	#HET	96	 933 	PRO	A	1	1 	J2I	A	B	2
FT	#HET	98	 935 	GLY	A	1	1 	J2I	A	B	11
FT	#HET	99	 936 	SER	A	1	1 	J2I	A	S	2
FT	#HET	143	 980 	ARG	A	1	1 	J2I	A	A	7
FT	#HET	144	 981 	ASN	A	1	1 	J2I	A	S	2
FT	#HET	146	 983 	LEU	A	1	1 	J2I	A	S	9
FT	#HET	156	 993 	GLY	A	1	1 	J2I	A	B	1
FT	#HET	157	 994 	ASP	A	1	1 	J2I	A	S	5
FT	DISORDER	1	2
FT	DISORDER	296	301
CC	SEQUENCE	293 AA (ATOM);
CC	DPTQFEERHL KFLQQLGKGN FGSVEMCRYD PLQDNTGEVV AVKKLQHSTE EHLRDFEREI
CC	EILKSLQHDN IVKYKGVCYS AGRRNLKLIM EYLPYGSLRD YLQKHKERID HIKLLQYTSQ
CC	ICKGMEYLGT KRYIHRDLAT RNILVENENR VKIGDFGLTK VLPQDKEYYK VKEPGESPIF
CC	WYAPESLTES KFSVASDVWS FGVVLYELFT YIEKSKSPPA EFMRMIGNDK QGQMIVFHLI
CC	ELLKNNGRLP RPDGCPDEIY MIMTECWNNN VNQRPSFRDL ALRVDQIRDN MAG
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS
CC	ATOM   --DPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS
CC	         ************************************************
CC	SEQRES TEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSL
CC	ATOM   TEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSL
CC	       **************************************************
CC	SEQRES RDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENE
CC	ATOM   RDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENE
CC	       **************************************************
CC	SEQRES NRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDV
CC	ATOM   NRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDV
CC	       **************************************************
CC	SEQRES WSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGR
CC	ATOM   WSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGR
CC	       **************************************************
CC	SEQRES LPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAGHHHHH
CC	ATOM   LPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG-----
CC	       *********************************************     
CC	SEQRES H
CC	ATOM   -
CC	        
SQ	SEQUENCE	301 AA;      MW;         CN;
	MRDPTQFEER HLKFLQQLGK GNFGSVEMCR YDPLQDNTGE VVAVKKLQHS TEEHLRDFER
	EIEILKSLQH DNIVKYKGVC YSAGRRNLKL IMEYLPYGSL RDYLQKHKER IDHIKLLQYT
	SQICKGMEYL GTKRYIHRDL ATRNILVENE NRVKIGDFGL TKVLPQDKEY YKVKEPGESP
	IFWYAPESLT ESKFSVASDV WSFGVVLYEL FTYIEKSKSP PAEFMRMIGN DKQGQMIVFH
	LIELLKNNGR LPRPDGCPDE IYMIMTECWN NNVNQRPSFR DLALRVDQIR DNMAGHHHHH
	H
//
ID	3Q32B	STANDARD;	PRT;	301	AA.
DT	CONVERTED FROM PDB (SEQRES) 3Q32
DE	Tyrosine-protein kinase JAK2
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.500
CC	R-Factor	0.178
FT	#SUB	267	1104 	GLU	B	253	1090 	ARG	A	Protein	S	9
FT	#SUB	267	1104 	GLU	B	255	1092 	ASP	A	Protein	S	4
FT	#SUB	267	1104 	GLU	B	256	1093 	GLY	A	Protein	S	4
FT	#SUB	270	1107 	ASN	B	255	1092 	ASP	A	Protein	S	2
FT	#SUB	272	1109 	ASN	B	108	 945 	LYS	A	Protein	S	4
FT	#SUB	272	1109 	ASN	B	213	1050 	TYR	A	Protein	S	4
FT	#SUB	274	1111 	ASN	B	108	 945 	LYS	A	Protein	S	3
FT	#SUB	274	1111 	ASN	B	109	 946 	GLU	A	Protein	S	3
FT	#SUB	274	1111 	ASN	B	110	 947 	ARG	A	Protein	S	1
FT	#SUB	274	1111 	ASN	B	111	 948 	ILE	A	Protein	S	6
FT	#SUB	274	1111 	ASN	B	112	 949 	ASP	A	Protein	S	2
FT	#SUB	274	1111 	ASN	B	113	 950 	HIS	A	Protein	B	3
FT	#SUB	274	1111 	ASN	B	213	1050 	TYR	A	Protein	A	3
FT	#SUB	275	1112 	GLN	B	211	1048 	PHE	A	Protein	S	2
FT	#SUB	275	1112 	GLN	B	212	1049 	THR	A	Protein	S	4
FT	#SUB	275	1112 	GLN	B	213	1050 	TYR	A	Protein	S	4
FT	#SUB	275	1112 	GLN	B	215	1052 	GLU	A	Protein	S	1
FT	#SUB	275	1112 	GLN	B	255	1092 	ASP	A	Protein	A	5
FT	#SUB	275	1112 	GLN	B	256	1093 	GLY	A	Protein	B	3
FT	#SUB	276	1113 	ARG	B	256	1093 	GLY	A	Protein	B	1
FT	#SUB	277	1114 	PRO	B	256	1093 	GLY	A	Protein	B	2
FT	#SUB	281	1118 	ASP	B	256	1093 	GLY	A	Protein	S	1
FT	#SUB	281	1118 	ASP	B	258	1095 	PRO	A	Protein	S	7
FT	#SUB	285	1122 	ARG	B	253	1090 	ARG	A	Protein	S	12
FT	#SUB	285	1122 	ARG	B	257	1094 	CYS	A	Protein	S	1
FT	#SUB	288	1125 	GLN	B	259	1096 	ASP	A	Protein	S	2
FT	#HET	18	 855 	LEU	B	2	2 	J2I	B	A	10
FT	#HET	19	 856 	GLY	B	2	2 	J2I	B	B	2
FT	#HET	20	 857 	LYS	B	2	2 	J2I	B	B	4
FT	#HET	21	 858 	GLY	B	2	2 	J2I	B	B	1
FT	#HET	24	 861 	GLY	B	2	2 	J2I	B	B	3
FT	#HET	25	 862 	SER	B	2	2 	J2I	B	B	3
FT	#HET	26	 863 	VAL	B	2	2 	J2I	B	A	5
FT	#HET	43	 880 	ALA	B	2	2 	J2I	B	S	4
FT	#HET	45	 882 	LYS	B	2	2 	J2I	B	S	4
FT	#HET	92	 929 	MET	B	2	2 	J2I	B	S	2
FT	#HET	93	 930 	GLU	B	2	2 	J2I	B	B	4
FT	#HET	94	 931 	TYR	B	2	2 	J2I	B	A	10
FT	#HET	95	 932 	LEU	B	2	2 	J2I	B	A	11
FT	#HET	96	 933 	PRO	B	2	2 	J2I	B	B	2
FT	#HET	98	 935 	GLY	B	2	2 	J2I	B	B	11
FT	#HET	99	 936 	SER	B	2	2 	J2I	B	S	2
FT	#HET	143	 980 	ARG	B	2	2 	J2I	B	A	8
FT	#HET	144	 981 	ASN	B	2	2 	J2I	B	S	4
FT	#HET	146	 983 	LEU	B	2	2 	J2I	B	S	7
FT	#HET	156	 993 	GLY	B	2	2 	J2I	B	B	1
FT	#HET	157	 994 	ASP	B	2	2 	J2I	B	S	6
FT	DISORDER	297	301
CC	SEQUENCE	296 AA (ATOM);
CC	MRDPTQFEER HLKFLQQLGK GNFGSVEMCR YDPLQDNTGE VVAVKKLQHS TEEHLRDFER
CC	EIEILKSLQH DNIVKYKGVC YSAGRRNLKL IMEYLPYGSL RDYLQKHKER IDHIKLLQYT
CC	SQICKGMEYL GTKRYIHRDL ATRNILVENE NRVKIGDFGL TKVLPQDKEY YKVKEPGESP
CC	IFWYAPESLT ESKFSVASDV WSFGVVLYEL FTYIEKSKSP PAEFMRMIGN DKQGQMIVFH
CC	LIELLKNNGR LPRPDGCPDE IYMIMTECWN NNVNQRPSFR DLALRVDQIR DNMAGH
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS
CC	ATOM   MRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS
CC	       **************************************************
CC	SEQRES TEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSL
CC	ATOM   TEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSL
CC	       **************************************************
CC	SEQRES RDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENE
CC	ATOM   RDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENE
CC	       **************************************************
CC	SEQRES NRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDV
CC	ATOM   NRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDV
CC	       **************************************************
CC	SEQRES WSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGR
CC	ATOM   WSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGR
CC	       **************************************************
CC	SEQRES LPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAGHHHHH
CC	ATOM   LPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAGH----
CC	       **********************************************    
CC	SEQRES H
CC	ATOM   -
CC	        
SQ	SEQUENCE	301 AA;      MW;         CN;
	MRDPTQFEER HLKFLQQLGK GNFGSVEMCR YDPLQDNTGE VVAVKKLQHS TEEHLRDFER
	EIEILKSLQH DNIVKYKGVC YSAGRRNLKL IMEYLPYGSL RDYLQKHKER IDHIKLLQYT
	SQICKGMEYL GTKRYIHRDL ATRNILVENE NRVKIGDFGL TKVLPQDKEY YKVKEPGESP
	IFWYAPESLT ESKFSVASDV WSFGVVLYEL FTYIEKSKSP PAEFMRMIGN DKQGQMIVFH
	LIELLKNNGR LPRPDGCPDE IYMIMTECWN NNVNQRPSFR DLALRVDQIR DNMAGHHHHH
	H
//