ID	3KYRA	STANDARD;	PRT;	405	AA.
DT	CONVERTED FROM PDB (SEQRES) 3KYR
DE	Beta-secretase 1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.600
CC	R-Factor	0.210
FT	#SUB	18	  46P	SER	A	124	 104 	GLU	B	Protein	S	2
FT	#SUB	19	  47P	PHE	A	124	 104 	GLU	B	Protein	B	1
FT	#SUB	20	  48P	VAL	A	95	  75 	LYS	B	Protein	A	4
FT	#SUB	20	  48P	VAL	A	124	 104 	GLU	B	Protein	A	2
FT	#SUB	20	  48P	VAL	A	125	 105 	SER	B	Protein	S	4
FT	#SUB	21	   1 	GLU	A	95	  75 	LYS	B	Protein	B	1
FT	#SUB	21	   1 	GLU	A	126	 106 	ASP	B	Protein	S	2
FT	#SUB	23	   3 	VAL	A	88	  68 	TYR	B	Protein	S	8
FT	#SUB	23	   3 	VAL	A	95	  75 	LYS	B	Protein	B	1
FT	#SUB	23	   3 	VAL	A	97	  77 	GLU	B	Protein	S	1
FT	#SUB	24	   4 	ASP	A	88	  68 	TYR	B	Protein	S	1
FT	#SUB	200	 180 	ASP	A	97	  77 	GLU	B	Protein	S	9
FT	#SUB	202	 182 	SER	A	86	  66 	GLY	B	Protein	S	1
FT	#SUB	202	 182 	SER	A	87	  67 	VAL	B	Protein	S	4
FT	#SUB	202	 182 	SER	A	88	  68 	TYR	B	Protein	S	1
FT	#SUB	202	 182 	SER	A	97	  77 	GLU	B	Protein	S	4
FT	#SUB	207	 187 	SER	A	312	 292 	THR	C	Protein	S	3
FT	#SUB	209	 189 	TRP	A	311	 291 	VAL	C	Protein	S	1
FT	#SUB	209	 189 	TRP	A	312	 292 	THR	C	Protein	S	4
FT	#SUB	310	 290 	GLU	A	311	 291 	VAL	C	Protein	S	3
FT	#SUB	311	 291 	VAL	A	209	 189 	TRP	C	Protein	S	1
FT	#SUB	311	 291 	VAL	A	310	 290 	GLU	C	Protein	S	2
FT	#SUB	311	 291 	VAL	A	314	 294 	GLN	C	Protein	S	3
FT	#SUB	312	 292 	THR	A	207	 187 	SER	C	Protein	S	3
FT	#SUB	312	 292 	THR	A	209	 189 	TRP	C	Protein	A	3
FT	#SUB	312	 292 	THR	A	393	 373 	PRO	C	Protein	B	1
FT	#SUB	313	 293 	ASN	A	393	 373 	PRO	C	Protein	B	1
FT	#SUB	314	 294 	GLN	A	311	 291 	VAL	C	Protein	S	4
FT	#SUB	393	 373 	PRO	A	312	 292 	THR	C	Protein	S	1
FT	#SUB	393	 373 	PRO	A	395	 375 	VAL	C	Protein	S	1
FT	#SUB	395	 375 	VAL	A	393	 373 	PRO	C	Protein	S	1
FT	#HET	24	   4 	ASP	A	2	500 	038	B	S	7
FT	#HET	54	  34 	GLY	A	1	500 	038	A	B	12
FT	#HET	55	  35 	SER	A	1	500 	038	A	A	3
FT	#HET	88	  68 	TYR	A	1	500 	038	A	S	5
FT	#HET	89	  69 	VAL	A	1	500 	038	A	S	1
FT	#HET	90	  70 	PRO	A	1	500 	038	A	A	13
FT	#HET	91	  71 	TYR	A	1	500 	038	A	A	6
FT	#HET	92	  72 	THR	A	1	500 	038	A	A	7
FT	#HET	95	  75 	LYS	A	1	500 	038	A	S	4
FT	#HET	146	 126 	ILE	A	1	500 	038	A	A	2
FT	#HET	148	 128 	ARG	A	1	500 	038	A	S	6
FT	#HET	176	 156 	GLY	A	2	500 	038	B	B	1
FT	#HET	218	 198 	TYR	A	1	500 	038	A	S	9
FT	#HET	244	 224 	LYS	A	1	500 	038	A	S	5
FT	#HET	246	 226 	ILE	A	1	500 	038	A	S	2
FT	#HET	248	 228 	ASP	A	1	500 	038	A	S	6
FT	#HET	255	 235 	ARG	A	1	500 	038	A	S	4
FT	#HET	349	 329 	THR	A	1	500 	038	A	S	6
FT	#HET	379	 359 	CYS	A	2	500 	038	B	S	1
FT	DISORDER	1	17
FT	DISORDER	178	188
FT	DISORDER	276	279
FT	DISORDER	330	336
FT	DISORDER	405	405
CC	SEQUENCE	365 AA (ATOM);
CC	SFVEMVDNLR GKSGQGYYVE MTVGSPPQTL NILVDTGSSN FAVGAAPHPF LHRYYQRQLS
CC	STYRDLRKGV YVPYTQGKWE GELGTDLVSI PHGPNVTVRA NIAAITESDK FFINGSNWEG
CC	ILGLAYAEIA RPDDSLEPFF DSLVKQTHVP NLFSLQLCGA SVGGSMIIGG IDHSLYTGSL
CC	WYTPIRREWY YEVIIVRVEI NGQDLKMDCK EYNYDKSIVD SGTTNLRLPK KVFEAAVKSI
CC	KAASSTEGFW LGEQLVCWQA GTTPWNIFPV ISLYLMGEVT NQSFRITILP QQYLRPVDDC
CC	YKFAISQSST GTVMGAVIME GFYVVFDRAR KRIGFAVSAC HVHDEFRTAA VEGPFVTLDM
CC	EDCGY
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES RLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNIL
CC	ATOM   -----------------SFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNIL
CC	                        *********************************
CC	SEQRES VDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGEL
CC	ATOM   VDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGEL
CC	       **************************************************
CC	SEQRES GTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPD
CC	ATOM   GTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPD
CC	       **************************************************
CC	SEQRES DSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGID
CC	ATOM   DSLEPFFDSLVKQTHVPNLFSLQLCGA-----------SVGGSMIIGGID
CC	       ***************************           ************
CC	SEQRES HSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSG
CC	ATOM   HSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSG
CC	       **************************************************
CC	SEQRES TTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIF
CC	ATOM   TTNLRLPKKVFEAAVKSIKAASSTE----GFWLGEQLVCWQAGTTPWNIF
CC	       *************************    *********************
CC	SEQRES PVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTG
CC	ATOM   PVISLYLMGEVTNQSFRITILPQQYLRPV-------DDCYKFAISQSSTG
CC	       *****************************       **************
CC	SEQRES TVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDME
CC	ATOM   TVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDME
CC	       **************************************************
CC	SEQRES DCGYN
CC	ATOM   DCGY-
CC	       **** 
SQ	SEQUENCE	405 AA;      MW;         CN;
	RLPRETDEEP EEPGRRGSFV EMVDNLRGKS GQGYYVEMTV GSPPQTLNIL VDTGSSNFAV
	GAAPHPFLHR YYQRQLSSTY RDLRKGVYVP YTQGKWEGEL GTDLVSIPHG PNVTVRANIA
	AITESDKFFI NGSNWEGILG LAYAEIARPD DSLEPFFDSL VKQTHVPNLF SLQLCGAGFP
	LNQSEVLASV GGSMIIGGID HSLYTGSLWY TPIRREWYYE VIIVRVEING QDLKMDCKEY
	NYDKSIVDSG TTNLRLPKKV FEAAVKSIKA ASSTEKFPDG FWLGEQLVCW QAGTTPWNIF
	PVISLYLMGE VTNQSFRITI LPQQYLRPVE DVATSQDDCY KFAISQSSTG TVMGAVIMEG
	FYVVFDRARK RIGFAVSACH VHDEFRTAAV EGPFVTLDME DCGYN
//
ID	3KYRB	STANDARD;	PRT;	405	AA.
DT	CONVERTED FROM PDB (SEQRES) 3KYR
DE	Beta-secretase 1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.600
CC	R-Factor	0.210
FT	#SUB	86	  66 	GLY	B	202	 182 	SER	A	Protein	B	1
FT	#SUB	87	  67 	VAL	B	202	 182 	SER	A	Protein	B	4
FT	#SUB	88	  68 	TYR	B	23	   3 	VAL	A	Protein	S	8
FT	#SUB	88	  68 	TYR	B	24	   4 	ASP	A	Protein	S	1
FT	#SUB	88	  68 	TYR	B	202	 182 	SER	A	Protein	B	1
FT	#SUB	95	  75 	LYS	B	20	  48P	VAL	A	Protein	S	4
FT	#SUB	95	  75 	LYS	B	21	   1 	GLU	A	Protein	S	1
FT	#SUB	95	  75 	LYS	B	23	   3 	VAL	A	Protein	S	1
FT	#SUB	97	  77 	GLU	B	23	   3 	VAL	A	Protein	S	1
FT	#SUB	97	  77 	GLU	B	200	 180 	ASP	A	Protein	S	9
FT	#SUB	97	  77 	GLU	B	202	 182 	SER	A	Protein	S	4
FT	#SUB	124	 104 	GLU	B	18	  46P	SER	A	Protein	S	2
FT	#SUB	124	 104 	GLU	B	19	  47P	PHE	A	Protein	S	1
FT	#SUB	124	 104 	GLU	B	20	  48P	VAL	A	Protein	S	2
FT	#SUB	125	 105 	SER	B	20	  48P	VAL	A	Protein	B	4
FT	#SUB	126	 106 	ASP	B	21	   1 	GLU	A	Protein	S	2
FT	#HET	54	  34 	GLY	B	2	500 	038	B	B	11
FT	#HET	55	  35 	SER	B	2	500 	038	B	S	1
FT	#HET	88	  68 	TYR	B	2	500 	038	B	S	5
FT	#HET	89	  69 	VAL	B	2	500 	038	B	S	1
FT	#HET	90	  70 	PRO	B	2	500 	038	B	A	11
FT	#HET	91	  71 	TYR	B	2	500 	038	B	A	7
FT	#HET	92	  72 	THR	B	2	500 	038	B	A	6
FT	#HET	146	 126 	ILE	B	2	500 	038	B	S	1
FT	#HET	148	 128 	ARG	B	2	500 	038	B	S	6
FT	#HET	218	 198 	TYR	B	2	500 	038	B	S	10
FT	#HET	244	 224 	LYS	B	2	500 	038	B	S	1
FT	#HET	246	 226 	ILE	B	2	500 	038	B	S	2
FT	#HET	248	 228 	ASP	B	2	500 	038	B	S	9
FT	#HET	251	 231 	THR	B	2	500 	038	B	S	1
FT	#HET	255	 235 	ARG	B	2	500 	038	B	S	5
FT	#HET	349	 329 	THR	B	2	500 	038	B	S	3
FT	DISORDER	1	17
FT	DISORDER	178	188
FT	DISORDER	276	278
FT	DISORDER	329	336
FT	DISORDER	403	405
CC	SEQUENCE	363 AA (ATOM);
CC	SFVEMVDNLR GKSGQGYYVE MTVGSPPQTL NILVDTGSSN FAVGAAPHPF LHRYYQRQLS
CC	STYRDLRKGV YVPYTQGKWE GELGTDLVSI PHGPNVTVRA NIAAITESDK FFINGSNWEG
CC	ILGLAYAEIA RPDDSLEPFF DSLVKQTHVP NLFSLQLCGA SVGGSMIIGG IDHSLYTGSL
CC	WYTPIRREWY YEVIIVRVEI NGQDLKMDCK EYNYDKSIVD SGTTNLRLPK KVFEAAVKSI
CC	KAASSTEDGF WLGEQLVCWQ AGTTPWNIFP VISLYLMGEV TNQSFRITIL PQQYLRPDDC
CC	YKFAISQSST GTVMGAVIME GFYVVFDRAR KRIGFAVSAC HVHDEFRTAA VEGPFVTLDM
CC	EDC
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES RLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNIL
CC	ATOM   -----------------SFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNIL
CC	                        *********************************
CC	SEQRES VDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGEL
CC	ATOM   VDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGEL
CC	       **************************************************
CC	SEQRES GTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPD
CC	ATOM   GTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPD
CC	       **************************************************
CC	SEQRES DSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGID
CC	ATOM   DSLEPFFDSLVKQTHVPNLFSLQLCGA-----------SVGGSMIIGGID
CC	       ***************************           ************
CC	SEQRES HSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSG
CC	ATOM   HSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSG
CC	       **************************************************
CC	SEQRES TTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIF
CC	ATOM   TTNLRLPKKVFEAAVKSIKAASSTE---DGFWLGEQLVCWQAGTTPWNIF
CC	       *************************   **********************
CC	SEQRES PVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTG
CC	ATOM   PVISLYLMGEVTNQSFRITILPQQYLRP--------DDCYKFAISQSSTG
CC	       ****************************        **************
CC	SEQRES TVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDME
CC	ATOM   TVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDME
CC	       **************************************************
CC	SEQRES DCGYN
CC	ATOM   DC---
CC	       **   
SQ	SEQUENCE	405 AA;      MW;         CN;
	RLPRETDEEP EEPGRRGSFV EMVDNLRGKS GQGYYVEMTV GSPPQTLNIL VDTGSSNFAV
	GAAPHPFLHR YYQRQLSSTY RDLRKGVYVP YTQGKWEGEL GTDLVSIPHG PNVTVRANIA
	AITESDKFFI NGSNWEGILG LAYAEIARPD DSLEPFFDSL VKQTHVPNLF SLQLCGAGFP
	LNQSEVLASV GGSMIIGGID HSLYTGSLWY TPIRREWYYE VIIVRVEING QDLKMDCKEY
	NYDKSIVDSG TTNLRLPKKV FEAAVKSIKA ASSTEKFPDG FWLGEQLVCW QAGTTPWNIF
	PVISLYLMGE VTNQSFRITI LPQQYLRPVE DVATSQDDCY KFAISQSSTG TVMGAVIMEG
	FYVVFDRARK RIGFAVSACH VHDEFRTAAV EGPFVTLDME DCGYN
//
ID	3KYRC	STANDARD;	PRT;	405	AA.
DT	CONVERTED FROM PDB (SEQRES) 3KYR
DE	Beta-secretase 1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.600
CC	R-Factor	0.210
FT	#SUB	207	 187 	SER	C	312	 292 	THR	A	Protein	S	3
FT	#SUB	209	 189 	TRP	C	311	 291 	VAL	A	Protein	S	1
FT	#SUB	209	 189 	TRP	C	312	 292 	THR	A	Protein	S	3
FT	#SUB	310	 290 	GLU	C	311	 291 	VAL	A	Protein	S	2
FT	#SUB	311	 291 	VAL	C	209	 189 	TRP	A	Protein	S	1
FT	#SUB	311	 291 	VAL	C	310	 290 	GLU	A	Protein	S	3
FT	#SUB	311	 291 	VAL	C	314	 294 	GLN	A	Protein	S	4
FT	#SUB	312	 292 	THR	C	207	 187 	SER	A	Protein	S	3
FT	#SUB	312	 292 	THR	C	209	 189 	TRP	A	Protein	A	4
FT	#SUB	312	 292 	THR	C	393	 373 	PRO	A	Protein	B	1
FT	#SUB	314	 294 	GLN	C	311	 291 	VAL	A	Protein	S	3
FT	#SUB	393	 373 	PRO	C	312	 292 	THR	A	Protein	S	1
FT	#SUB	393	 373 	PRO	C	313	 293 	ASN	A	Protein	S	1
FT	#SUB	393	 373 	PRO	C	395	 375 	VAL	A	Protein	S	1
FT	#SUB	395	 375 	VAL	C	393	 373 	PRO	A	Protein	S	1
FT	#HET	54	  34 	GLY	C	3	500 	038	C	B	9
FT	#HET	55	  35 	SER	C	3	500 	038	C	S	1
FT	#HET	88	  68 	TYR	C	3	500 	038	C	S	4
FT	#HET	89	  69 	VAL	C	3	500 	038	C	S	1
FT	#HET	90	  70 	PRO	C	3	500 	038	C	A	14
FT	#HET	91	  71 	TYR	C	3	500 	038	C	A	6
FT	#HET	92	  72 	THR	C	3	500 	038	C	A	11
FT	#HET	146	 126 	ILE	C	3	500 	038	C	S	1
FT	#HET	148	 128 	ARG	C	3	500 	038	C	S	8
FT	#HET	218	 198 	TYR	C	3	500 	038	C	S	6
FT	#HET	244	 224 	LYS	C	3	500 	038	C	S	3
FT	#HET	246	 226 	ILE	C	3	500 	038	C	S	2
FT	#HET	248	 228 	ASP	C	3	500 	038	C	S	10
FT	#HET	251	 231 	THR	C	3	500 	038	C	S	1
FT	#HET	255	 235 	ARG	C	3	500 	038	C	S	6
FT	#HET	349	 329 	THR	C	3	500 	038	C	S	1
FT	DISORDER	1	17
FT	DISORDER	178	188
FT	DISORDER	272	280
FT	DISORDER	330	337
CC	SEQUENCE	360 AA (ATOM);
CC	SFVEMVDNLR GKSGQGYYVE MTVGSPPQTL NILVDTGSSN FAVGAAPHPF LHRYYQRQLS
CC	STYRDLRKGV YVPYTQGKWE GELGTDLVSI PHGPNVTVRA NIAAITESDK FFINGSNWEG
CC	ILGLAYAEIA RPDDSLEPFF DSLVKQTHVP NLFSLQLCGA SVGGSMIIGG IDHSLYTGSL
CC	WYTPIRREWY YEVIIVRVEI NGQDLKMDCK EYNYDKSIVD SGTTNLRLPK KVFEAAVKSI
CC	KAAFWLGEQL VCWQAGTTPW NIFPVISLYL MGEVTNQSFR ITILPQQYLR PVDCYKFAIS
CC	QSSTGTVMGA VIMEGFYVVF DRARKRIGFA VSACHVHDEF RTAAVEGPFV TLDMEDCGYN
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES RLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNIL
CC	ATOM   -----------------SFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNIL
CC	                        *********************************
CC	SEQRES VDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGEL
CC	ATOM   VDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGEL
CC	       **************************************************
CC	SEQRES GTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPD
CC	ATOM   GTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPD
CC	       **************************************************
CC	SEQRES DSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGID
CC	ATOM   DSLEPFFDSLVKQTHVPNLFSLQLCGA-----------SVGGSMIIGGID
CC	       ***************************           ************
CC	SEQRES HSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSG
CC	ATOM   HSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSG
CC	       **************************************************
CC	SEQRES TTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIF
CC	ATOM   TTNLRLPKKVFEAAVKSIKAA---------FWLGEQLVCWQAGTTPWNIF
CC	       *********************         ********************
CC	SEQRES PVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTG
CC	ATOM   PVISLYLMGEVTNQSFRITILPQQYLRPV--------DCYKFAISQSSTG
CC	       *****************************        *************
CC	SEQRES TVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDME
CC	ATOM   TVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDME
CC	       **************************************************
CC	SEQRES DCGYN
CC	ATOM   DCGYN
CC	       *****
SQ	SEQUENCE	405 AA;      MW;         CN;
	RLPRETDEEP EEPGRRGSFV EMVDNLRGKS GQGYYVEMTV GSPPQTLNIL VDTGSSNFAV
	GAAPHPFLHR YYQRQLSSTY RDLRKGVYVP YTQGKWEGEL GTDLVSIPHG PNVTVRANIA
	AITESDKFFI NGSNWEGILG LAYAEIARPD DSLEPFFDSL VKQTHVPNLF SLQLCGAGFP
	LNQSEVLASV GGSMIIGGID HSLYTGSLWY TPIRREWYYE VIIVRVEING QDLKMDCKEY
	NYDKSIVDSG TTNLRLPKKV FEAAVKSIKA ASSTEKFPDG FWLGEQLVCW QAGTTPWNIF
	PVISLYLMGE VTNQSFRITI LPQQYLRPVE DVATSQDDCY KFAISQSSTG TVMGAVIMEG
	FYVVFDRARK RIGFAVSACH VHDEFRTAAV EGPFVTLDME DCGYN
//