ID 3JD8A STANDARD; PRT; 1278 AA. DT CONVERTED FROM PDB (SEQRES) 3JD8 DE Niemann-Pick C1 protein OS Homo sapiens CC EXPDTA ELECTRON MICROSCOPY CC RESOLU 4.430 FT #HET 41 41 ASN A 25 1325 CLR A S 5 FT #HET 65 65 GLY A 1 1 NAG B B 4 FT #HET 65 65 GLY A 2 2 NAG B B 6 FT #HET 66 66 PHE A 1 1 NAG B A 4 FT #HET 68 68 PHE A 2 2 NAG B S 9 FT #HET 79 79 GLN A 25 1325 CLR A A 5 FT #HET 82 82 THR A 25 1325 CLR A S 2 FT #HET 83 83 LEU A 25 1325 CLR A A 4 FT #HET 86 86 ASN A 25 1325 CLR A A 4 FT #HET 88 88 GLN A 4 2 NAG C S 4 FT #HET 90 90 PRO A 25 1325 CLR A S 2 FT #HET 106 106 ASN A 1 1 NAG B S 2 FT #HET 108 108 PHE A 25 1325 CLR A S 3 FT #HET 109 109 CYS A 1 1 NAG B S 1 FT #HET 110 110 GLU A 1 1 NAG B S 6 FT #HET 111 111 LEU A 25 1325 CLR A S 2 FT #HET 112 112 THR A 25 1325 CLR A S 3 FT #HET 176 176 LEU A 25 1325 CLR A A 4 FT #HET 183 183 ALA A 19 1319 NAG A A 10 FT #HET 187 187 THR A 19 1319 NAG A S 1 FT #HET 188 188 ASN A 19 1319 NAG A S 4 FT #HET 192 192 TYR A 25 1325 CLR A S 3 FT #HET 193 193 MET A 25 1325 CLR A A 8 FT #HET 198 198 ASN A 25 1325 CLR A S 2 FT #HET 200 200 GLN A 25 1325 CLR A A 2 FT #HET 201 201 ALA A 25 1325 CLR A A 3 FT #HET 202 202 PRO A 25 1325 CLR A S 2 FT #HET 203 203 PHE A 25 1325 CLR A S 2 FT #HET 205 205 ILE A 25 1325 CLR A S 1 FT #HET 244 244 SER A 14 1303 NAG A S 2 FT #HET 245 245 ILE A 14 1303 NAG A S 1 FT #HET 417 417 LYS A 5 1 NAG D S 1 FT #HET 428 428 ASP A 7 3 BMA D S 1 FT #HET 430 430 PRO A 5 1 NAG D S 1 FT #HET 442 442 GLN A 8 1 NAG E S 2 FT #HET 452 452 ASN A 23 1323 NAG A S 9 FT #HET 475 475 TYR A 10 1 NAG F B 2 FT #HET 476 476 ASN A 10 1 NAG F A 11 FT #HET 478 478 ASN A 10 1 NAG F S 11 FT #HET 551 551 ASP A 5 1 NAG D S 1 FT #HET 554 554 ASN A 5 1 NAG D S 6 FT #HET 571 571 TYR A 15 1309 NAG A S 3 FT #HET 596 596 ASN A 8 1 NAG E S 4 FT #HET 1013 1013 LYS A 3 1 NAG C B 1 FT #HET 1072 1072 ASN A 21 1321 NAG A S 6 FT #MOD 70 70 ASN A 17 1317 NAG A S FT #MOD 122 122 ASN A 16 1316 NAG A S FT #MOD 135 135 ASN A 22 1322 NAG A S FT #MOD 158 158 ASN A 14 1303 NAG A S FT #MOD 185 185 ASN A 19 1319 NAG A S FT #MOD 222 222 ASN A 1 1 NAG B S FT #MOD 459 459 ASN A 24 1324 NAG A S FT #MOD 524 524 ASN A 3 1 NAG C S FT #MOD 557 557 ASN A 5 1 NAG D S FT #MOD 572 572 ASN A 15 1309 NAG A S FT #MOD 598 598 ASN A 8 1 NAG E S FT #MOD 1064 1064 ASN A 20 1320 NAG A S FT DISORDER 1 22 FT DISORDER 289 329 FT DISORDER 773 803 FT DISORDER 960 983 FT DISORDER 1252 1278 CC SEQUENCE 1133 AA (ATOM); CC QSCVWYGECG IAYGDKRYNC EYSGPPKPLP KDGYDLVQEL CPGFFFGNVS LCCDVRQLQT CC LKDNLQLPLQ FLSRCPSCFY NLLNLFCELT CSPRQSQFLN VTATEDYVDP VTNQTKTNVK CC ELQYYVGQSF ANAMYNACRD VEAPSSNDKA LGLLCGKDAD ACNATNWIEY MFNKDNGQAP CC FTITPVFSDF PVHGMEPMNN ATKGCDESVD EVTAPCSCQD CSIVCGPKPQ PPPPPAPWTI CC LGLDAMYVIM WITYMAFLLV FFGAFFAFEG CLRRLFTRWG SFCVRNPGCV IFFSLVFITA CC CSSGLVFVRV TTNPVDLWSA PSSQARLEKE YFDQHFGPFF RTEQLIIRAP LTDKHIYQPY CC PSGADVPFGP PLDIQILHQV LDLQIAIENI TASYDNETVT LQDICLAPLS PYNTNCTILS CC VLNYFQNSHS VLDHKKGDDF FVYADYHTHF LYCVRAPASL NDTSLLHDPC LGTFGGPVFP CC WLVLGGYDDQ NYNNATALVI TFPVNNYYND TEKLQRAQAW EKEFINFVKN YKNPNLTISF CC TAERSIEDEL NRESDSDVFT VVISYAIMFL YISLALGHMK SCRRLLVDSK VSLGIAGILI CC VLSSVACSLG VFSYIGLPLT LIVIEVIPFL VLAVGVDNIF ILVQAYQRDE RLQGETLDQQ CC LGRVLGEVAP SMFLSSFSET VAFFLGALSV MPAVHTFSLF AGLAVFIDFA EDGTSVQASE CC SCLFRFFKNS YSPLLLKDWM RPIVIAIFVG VLSFSIAVLN KVDIGLDQSL SMPDDSYMVD CC YFKSISQYLH AGPPVYFVLE EGHDYTSSKG QNMVCGGMGC NNDSLVQQIF NAAQLDNYTR CC IGFAPSSWID DYFDWVKPQS SCCRVPEGKQ RPQGGDFMRF LPMFLSDNPN PKCGKGGHAA CC YSSAVNILLG HGTRVGATYF MTYHTVLQTS ADFIDALKKA RLIASNVTET MGINGSAYRV CC FPYSVFYVFY EQYLTIIDDT IFNLGVSLGA IFLVTMVLLG CELWSAVIMC ATIAMVLVNM CC FGVMWLWGIS LNAVSLVNLV MSCGISVEFC SHITRAFTVS MKGSRVERAE EALAHMGSSV CC FSGITLTKFG GIVVLAFAKS QIFQIFYFRM YLAMVLLGAT HGLIFLPVLL SYI CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPKP CC ATOM ----------------------QSCVWYGECGIAYGDKRYNCEYSGPPKP CC **************************** CC SEQRES LPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSC CC ATOM LPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSC CC ************************************************** CC SEQRES FYNLLNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQ CC ATOM FYNLLNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQ CC ************************************************** CC SEQRES SFANAMYNACRDVEAPSSNDKALGLLCGKDADACNATNWIEYMFNKDNGQ CC ATOM SFANAMYNACRDVEAPSSNDKALGLLCGKDADACNATNWIEYMFNKDNGQ CC ************************************************** CC SEQRES APFTITPVFSDFPVHGMEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPK CC ATOM APFTITPVFSDFPVHGMEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPK CC ************************************************** CC SEQRES PQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFAVWCYRKRYFVS CC ATOM PQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFF------------ CC ************************************** CC SEQRES EYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRNP CC ATOM -----------------------------AFEGCLRRLFTRWGSFCVRNP CC ********************* CC SEQRES GCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFG CC ATOM GCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFG CC ************************************************** CC SEQRES PFFRTEQLIIRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAI CC ATOM PFFRTEQLIIRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAI CC ************************************************** CC SEQRES ENITASYDNETVTLQDICLAPLSPYNTNCTILSVLNYFQNSHSVLDHKKG CC ATOM ENITASYDNETVTLQDICLAPLSPYNTNCTILSVLNYFQNSHSVLDHKKG CC ************************************************** CC SEQRES DDFFVYADYHTHFLYCVRAPASLNDTSLLHDPCLGTFGGPVFPWLVLGGY CC ATOM DDFFVYADYHTHFLYCVRAPASLNDTSLLHDPCLGTFGGPVFPWLVLGGY CC ************************************************** CC SEQRES DDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYKNPNLT CC ATOM DDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYKNPNLT CC ************************************************** CC SEQRES ISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLLV CC ATOM ISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLLV CC ************************************************** CC SEQRES DSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVD CC ATOM DSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVD CC ************************************************** CC SEQRES NIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGA CC ATOM NIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGA CC ************************************************** CC SEQRES LSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCC CC ATOM LSVMPAVHTFSLFAGLAVFIDF---------------------------- CC ********************** CC SEQRES VRGAEDGTSVQASESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSI CC ATOM ---AEDGTSVQASESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSI CC *********************************************** CC SEQRES AVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYT CC ATOM AVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYT CC ************************************************** CC SEQRES SSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDWV CC ATOM SSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDWV CC ************************************************** CC SEQRES KPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLP CC ATOM KPQSSCCRV------------------------PEGKQRPQGGDFMRFLP CC ********* ***************** CC SEQRES MFLSDNPNPKCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSAD CC ATOM MFLSDNPNPKCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSAD CC ************************************************** CC SEQRES FIDALKKARLIASNVTETMGINGSAYRVFPYSVFYVFYEQYLTIIDDTIF CC ATOM FIDALKKARLIASNVTETMGINGSAYRVFPYSVFYVFYEQYLTIIDDTIF CC ************************************************** CC SEQRES NLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLN CC ATOM NLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLN CC ************************************************** CC SEQRES AVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFS CC ATOM AVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFS CC ************************************************** CC SEQRES GITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSY CC ATOM GITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSY CC ************************************************** CC SEQRES IGPSVNKAKSCATEERYKGTERERLLNF CC ATOM I--------------------------- CC * SQ SEQUENCE 1278 AA; MW; CN; MTARGLALGL LLLLLCPAQV FSQSCVWYGE CGIAYGDKRY NCEYSGPPKP LPKDGYDLVQ ELCPGFFFGN VSLCCDVRQL QTLKDNLQLP LQFLSRCPSC FYNLLNLFCE LTCSPRQSQF LNVTATEDYV DPVTNQTKTN VKELQYYVGQ SFANAMYNAC RDVEAPSSND KALGLLCGKD ADACNATNWI EYMFNKDNGQ APFTITPVFS DFPVHGMEPM NNATKGCDES VDEVTAPCSC QDCSIVCGPK PQPPPPPAPW TILGLDAMYV IMWITYMAFL LVFFGAFFAV WCYRKRYFVS EYTPIDSNIA FSVNASDKGE ASCCDPVSAA FEGCLRRLFT RWGSFCVRNP GCVIFFSLVF ITACSSGLVF VRVTTNPVDL WSAPSSQARL EKEYFDQHFG PFFRTEQLII RAPLTDKHIY QPYPSGADVP FGPPLDIQIL HQVLDLQIAI ENITASYDNE TVTLQDICLA PLSPYNTNCT ILSVLNYFQN SHSVLDHKKG DDFFVYADYH THFLYCVRAP ASLNDTSLLH DPCLGTFGGP VFPWLVLGGY DDQNYNNATA LVITFPVNNY YNDTEKLQRA QAWEKEFINF VKNYKNPNLT ISFTAERSIE DELNRESDSD VFTVVISYAI MFLYISLALG HMKSCRRLLV DSKVSLGIAG ILIVLSSVAC SLGVFSYIGL PLTLIVIEVI PFLVLAVGVD NIFILVQAYQ RDERLQGETL DQQLGRVLGE VAPSMFLSSF SETVAFFLGA LSVMPAVHTF SLFAGLAVFI DFLLQITCFV SLLGLDIKRQ EKNRLDIFCC VRGAEDGTSV QASESCLFRF FKNSYSPLLL KDWMRPIVIA IFVGVLSFSI AVLNKVDIGL DQSLSMPDDS YMVDYFKSIS QYLHAGPPVY FVLEEGHDYT SSKGQNMVCG GMGCNNDSLV QQIFNAAQLD NYTRIGFAPS SWIDDYFDWV KPQSSCCRVD NITDQFCNAS VVDPACVRCR PLTPEGKQRP QGGDFMRFLP MFLSDNPNPK CGKGGHAAYS SAVNILLGHG TRVGATYFMT YHTVLQTSAD FIDALKKARL IASNVTETMG INGSAYRVFP YSVFYVFYEQ YLTIIDDTIF NLGVSLGAIF LVTMVLLGCE LWSAVIMCAT IAMVLVNMFG VMWLWGISLN AVSLVNLVMS CGISVEFCSH ITRAFTVSMK GSRVERAEEA LAHMGSSVFS GITLTKFGGI VVLAFAKSQI FQIFYFRMYL AMVLLGATHG LIFLPVLLSY IGPSVNKAKS CATEERYKGT ERERLLNF //