ID	3H5UA	STANDARD;	PRT;	576	AA.
DT	CONVERTED FROM PDB (SEQRES) 3H5U
DE	RNA-directed RNA polymerase
OS	Hepatitis C virus
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	1.950
CC	R-Factor	0.209
FT	#SUB	75	  69 	LYS	A	443	 437 	GLU	B	Protein	S	1
FT	#SUB	79	  73 	ALA	A	441	 435 	ALA	B	Protein	S	1
FT	#SUB	79	  73 	ALA	A	442	 436 	GLN	B	Protein	A	6
FT	#SUB	80	  74 	LYS	A	442	 436 	GLN	B	Protein	A	3
FT	#SUB	82	  76 	SER	A	31	  25 	ALA	B	Protein	B	1
FT	#SUB	83	  77 	THR	A	30	  24 	ASN	B	Protein	B	5
FT	#SUB	83	  77 	THR	A	31	  25 	ALA	B	Protein	B	6
FT	#SUB	83	  77 	THR	A	32	  26 	LEU	B	Protein	S	1
FT	#SUB	83	  77 	THR	A	442	 436 	GLN	B	Protein	S	1
FT	#SUB	84	  78 	VAL	A	31	  25 	ALA	B	Protein	B	1
FT	#SUB	85	  79 	LYS	A	29	  23 	ILE	B	Protein	S	1
FT	#SUB	85	  79 	LYS	A	30	  24 	ASN	B	Protein	S	4
FT	#SUB	85	  79 	LYS	A	31	  25 	ALA	B	Protein	A	2
FT	#SUB	85	  79 	LYS	A	34	  28 	ASN	B	Protein	S	1
FT	#SUB	215	 209 	LYS	A	108	 102 	GLY	B	Protein	S	1
FT	#SUB	250	 244 	ASP	A	31	  25 	ALA	B	Protein	S	1
FT	#SUB	385	 379 	LYS	A	106	 100 	LYS	B	Protein	S	4
FT	#SUB	385	 379 	LYS	A	108	 102 	GLY	B	Protein	S	1
FT	#SUB	470	 464 	GLU	A	276	 270 	LYS	B	Protein	S	1
FT	#SUB	544	 538 	PRO	A	276	 270 	LYS	B	Protein	S	2
FT	#SUB	544	 538 	PRO	A	278	 272 	GLN	B	Protein	S	7
FT	#SUB	549	 543 	SER	A	276	 270 	LYS	B	Protein	A	3
FT	#SUB	550	 544 	ARG	A	16	  10 	LEU	B	Protein	S	1
FT	#HET	199	 193 	PHE	A	1	571 	H5U	A	S	6
FT	#HET	203	 197 	PRO	A	1	571 	H5U	A	A	4
FT	#HET	206	 200 	ARG	A	1	571 	H5U	A	S	2
FT	#HET	294	 288 	SER	A	1	571 	H5U	A	A	3
FT	#HET	297	 291 	ASN	A	1	571 	H5U	A	S	5
FT	#HET	322	 316 	ASN	A	1	571 	H5U	A	A	3
FT	#HET	323	 317 	GLY	A	1	571 	H5U	A	B	3
FT	#HET	324	 318 	ASP	A	1	571 	H5U	A	A	5
FT	#HET	325	 319 	ASP	A	1	571 	H5U	A	S	1
FT	#HET	372	 366 	CYS	A	1	571 	H5U	A	A	6
FT	#HET	390	 384 	LEU	A	1	571 	H5U	A	S	1
FT	#HET	416	 410 	GLY	A	1	571 	H5U	A	B	1
FT	#HET	417	 411 	ASN	A	1	571 	H5U	A	S	1
FT	#HET	420	 414 	MET	A	1	571 	H5U	A	A	7
FT	#HET	421	 415 	TYR	A	1	571 	H5U	A	S	7
FT	#HET	452	 446 	GLN	A	1	571 	H5U	A	B	2
FT	#HET	453	 447 	ILE	A	1	571 	H5U	A	A	3
FT	#HET	454	 448 	TYR	A	1	571 	H5U	A	A	13
FT	#HET	455	 449 	GLY	A	1	571 	H5U	A	B	4
FT	#HET	562	 556 	SER	A	1	571 	H5U	A	S	9
FT	DISORDER	1	6
FT	DISORDER	155	158
FT	DISORDER	570	576
CC	SEQUENCE	559 AA (ATOM);
CC	HMSYTWTGAL ITPCAAEESK LPINALSNSL LRHHNMVYAT TSRSAGLRQK KVTFDRLQVL
CC	DDHYRDVLKE MKAKASTVKA KLLSVEEACK LTPPHSAKSK FGYGAKDVRN LSSKAVNHIH
CC	SVWKDLLEDT VTPIDTTIMA KNEVFCVQGR KPARLIVFPD LGVRVCEKMA LYDVVSTLPQ
CC	VVMGSSYGFQ YSPGQRVEFL VNTWKSKKNP MGFSYDTRCF DSTVTENDIR VEESIYQCCD
CC	LAPEARQAIK SLTERLYIGG PLTNSKGQNC GYRRCRASGV LTTSCGNTLT CYLKASAACR
CC	AAKLQDCTML VNGDDLVVIC ESAGTQEDAA SLRVFTEAMT RYSAPPGDPP QPEYDLELIT
CC	SCSSNVSVAH DASGKRVYYL TRDPTTPLAR AAWETARHTP VNSWLGNIIM YAPTLWARMI
CC	LMTHFFSILL AQEQLEKALD CQIYGACYSI EPLDLPQIIE RLHGLSAFSL HSYSPGEINR
CC	VASCLRKLGV PPLRVWRHRA RSVRARLLSQ GGRAATCGKY LFNWAVKTKL KLTPIPAASR
CC	LDLSGWFVAG YSGGDIYHS
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MHHHHHHMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRS
CC	ATOM   ------HMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRS
CC	             ********************************************
CC	SEQRES AGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPP
CC	ATOM   AGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPP
CC	       **************************************************
CC	SEQRES HSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEV
CC	ATOM   HSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEV
CC	       **************************************************
CC	SEQRES FCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQ
CC	ATOM   FCVQ----GRKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQ
CC	       ****    ******************************************
CC	SEQRES YSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCD
CC	ATOM   YSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCD
CC	       **************************************************
CC	SEQRES LAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLT
CC	ATOM   LAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLT
CC	       **************************************************
CC	SEQRES CYLKASAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMT
CC	ATOM   CYLKASAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMT
CC	       **************************************************
CC	SEQRES RYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLAR
CC	ATOM   RYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLAR
CC	       **************************************************
CC	SEQRES AAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALD
CC	ATOM   AAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALD
CC	       **************************************************
CC	SEQRES CQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGV
CC	ATOM   CQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGV
CC	       **************************************************
CC	SEQRES PPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASR
CC	ATOM   PPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASR
CC	       **************************************************
CC	SEQRES LDLSGWFVAGYSGGDIYHSLSRARPR
CC	ATOM   LDLSGWFVAGYSGGDIYHS-------
CC	       *******************       
SQ	SEQUENCE	576 AA;      MW;         CN;
	MHHHHHHMSY TWTGALITPC AAEESKLPIN ALSNSLLRHH NMVYATTSRS AGLRQKKVTF
	DRLQVLDDHY RDVLKEMKAK ASTVKAKLLS VEEACKLTPP HSAKSKFGYG AKDVRNLSSK
	AVNHIHSVWK DLLEDTVTPI DTTIMAKNEV FCVQPEKGGR KPARLIVFPD LGVRVCEKMA
	LYDVVSTLPQ VVMGSSYGFQ YSPGQRVEFL VNTWKSKKNP MGFSYDTRCF DSTVTENDIR
	VEESIYQCCD LAPEARQAIK SLTERLYIGG PLTNSKGQNC GYRRCRASGV LTTSCGNTLT
	CYLKASAACR AAKLQDCTML VNGDDLVVIC ESAGTQEDAA SLRVFTEAMT RYSAPPGDPP
	QPEYDLELIT SCSSNVSVAH DASGKRVYYL TRDPTTPLAR AAWETARHTP VNSWLGNIIM
	YAPTLWARMI LMTHFFSILL AQEQLEKALD CQIYGACYSI EPLDLPQIIE RLHGLSAFSL
	HSYSPGEINR VASCLRKLGV PPLRVWRHRA RSVRARLLSQ GGRAATCGKY LFNWAVKTKL
	KLTPIPAASR LDLSGWFVAG YSGGDIYHSL SRARPR
//
ID	3H5UB	STANDARD;	PRT;	576	AA.
DT	CONVERTED FROM PDB (SEQRES) 3H5U
DE	RNA-directed RNA polymerase
OS	Hepatitis C virus
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	1.950
CC	R-Factor	0.209
FT	#SUB	16	  10 	LEU	B	550	 544 	ARG	A	Protein	S	1
FT	#SUB	29	  23 	ILE	B	85	  79 	LYS	A	Protein	S	1
FT	#SUB	30	  24 	ASN	B	83	  77 	THR	A	Protein	A	5
FT	#SUB	30	  24 	ASN	B	85	  79 	LYS	A	Protein	B	4
FT	#SUB	31	  25 	ALA	B	82	  76 	SER	A	Protein	S	1
FT	#SUB	31	  25 	ALA	B	83	  77 	THR	A	Protein	A	6
FT	#SUB	31	  25 	ALA	B	84	  78 	VAL	A	Protein	S	1
FT	#SUB	31	  25 	ALA	B	85	  79 	LYS	A	Protein	B	2
FT	#SUB	31	  25 	ALA	B	250	 244 	ASP	A	Protein	S	1
FT	#SUB	32	  26 	LEU	B	83	  77 	THR	A	Protein	S	1
FT	#SUB	34	  28 	ASN	B	85	  79 	LYS	A	Protein	S	1
FT	#SUB	106	 100 	LYS	B	385	 379 	LYS	A	Protein	B	4
FT	#SUB	108	 102 	GLY	B	215	 209 	LYS	A	Protein	B	1
FT	#SUB	108	 102 	GLY	B	385	 379 	LYS	A	Protein	B	1
FT	#SUB	276	 270 	LYS	B	470	 464 	GLU	A	Protein	S	1
FT	#SUB	276	 270 	LYS	B	544	 538 	PRO	A	Protein	A	2
FT	#SUB	276	 270 	LYS	B	549	 543 	SER	A	Protein	S	3
FT	#SUB	278	 272 	GLN	B	544	 538 	PRO	A	Protein	S	7
FT	#SUB	441	 435 	ALA	B	79	  73 	ALA	A	Protein	B	1
FT	#SUB	442	 436 	GLN	B	79	  73 	ALA	A	Protein	S	6
FT	#SUB	442	 436 	GLN	B	80	  74 	LYS	A	Protein	S	3
FT	#SUB	442	 436 	GLN	B	83	  77 	THR	A	Protein	S	1
FT	#SUB	443	 437 	GLU	B	75	  69 	LYS	A	Protein	S	1
FT	#HET	199	 193 	PHE	B	2	571 	H5U	B	S	6
FT	#HET	203	 197 	PRO	B	2	571 	H5U	B	A	4
FT	#HET	206	 200 	ARG	B	2	571 	H5U	B	S	2
FT	#HET	294	 288 	SER	B	2	571 	H5U	B	A	3
FT	#HET	297	 291 	ASN	B	2	571 	H5U	B	S	5
FT	#HET	322	 316 	ASN	B	2	571 	H5U	B	A	3
FT	#HET	323	 317 	GLY	B	2	571 	H5U	B	B	3
FT	#HET	324	 318 	ASP	B	2	571 	H5U	B	A	4
FT	#HET	325	 319 	ASP	B	2	571 	H5U	B	S	1
FT	#HET	372	 366 	CYS	B	2	571 	H5U	B	A	8
FT	#HET	374	 368 	SER	B	2	571 	H5U	B	S	1
FT	#HET	390	 384 	LEU	B	2	571 	H5U	B	S	1
FT	#HET	417	 411 	ASN	B	2	571 	H5U	B	S	1
FT	#HET	420	 414 	MET	B	2	571 	H5U	B	A	6
FT	#HET	421	 415 	TYR	B	2	571 	H5U	B	S	7
FT	#HET	452	 446 	GLN	B	2	571 	H5U	B	B	2
FT	#HET	453	 447 	ILE	B	2	571 	H5U	B	A	3
FT	#HET	454	 448 	TYR	B	2	571 	H5U	B	A	13
FT	#HET	455	 449 	GLY	B	2	571 	H5U	B	B	4
FT	#HET	562	 556 	SER	B	2	571 	H5U	B	S	5
FT	DISORDER	1	6
FT	DISORDER	155	158
FT	DISORDER	570	576
CC	SEQUENCE	559 AA (ATOM);
CC	HMSYTWTGAL ITPCAAEESK LPINALSNSL LRHHNMVYAT TSRSAGLRQK KVTFDRLQVL
CC	DDHYRDVLKE MKAKASTVKA KLLSVEEACK LTPPHSAKSK FGYGAKDVRN LSSKAVNHIH
CC	SVWKDLLEDT VTPIDTTIMA KNEVFCVQGR KPARLIVFPD LGVRVCEKMA LYDVVSTLPQ
CC	VVMGSSYGFQ YSPGQRVEFL VNTWKSKKNP MGFSYDTRCF DSTVTENDIR VEESIYQCCD
CC	LAPEARQAIK SLTERLYIGG PLTNSKGQNC GYRRCRASGV LTTSCGNTLT CYLKASAACR
CC	AAKLQDCTML VNGDDLVVIC ESAGTQEDAA SLRVFTEAMT RYSAPPGDPP QPEYDLELIT
CC	SCSSNVSVAH DASGKRVYYL TRDPTTPLAR AAWETARHTP VNSWLGNIIM YAPTLWARMI
CC	LMTHFFSILL AQEQLEKALD CQIYGACYSI EPLDLPQIIE RLHGLSAFSL HSYSPGEINR
CC	VASCLRKLGV PPLRVWRHRA RSVRARLLSQ GGRAATCGKY LFNWAVKTKL KLTPIPAASR
CC	LDLSGWFVAG YSGGDIYHS
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MHHHHHHMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRS
CC	ATOM   ------HMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRS
CC	             ********************************************
CC	SEQRES AGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPP
CC	ATOM   AGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPP
CC	       **************************************************
CC	SEQRES HSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEV
CC	ATOM   HSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEV
CC	       **************************************************
CC	SEQRES FCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQ
CC	ATOM   FCVQ----GRKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQ
CC	       ****    ******************************************
CC	SEQRES YSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCD
CC	ATOM   YSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCD
CC	       **************************************************
CC	SEQRES LAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLT
CC	ATOM   LAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLT
CC	       **************************************************
CC	SEQRES CYLKASAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMT
CC	ATOM   CYLKASAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMT
CC	       **************************************************
CC	SEQRES RYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLAR
CC	ATOM   RYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLAR
CC	       **************************************************
CC	SEQRES AAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALD
CC	ATOM   AAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALD
CC	       **************************************************
CC	SEQRES CQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGV
CC	ATOM   CQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGV
CC	       **************************************************
CC	SEQRES PPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASR
CC	ATOM   PPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASR
CC	       **************************************************
CC	SEQRES LDLSGWFVAGYSGGDIYHSLSRARPR
CC	ATOM   LDLSGWFVAGYSGGDIYHS-------
CC	       *******************       
SQ	SEQUENCE	576 AA;      MW;         CN;
	MHHHHHHMSY TWTGALITPC AAEESKLPIN ALSNSLLRHH NMVYATTSRS AGLRQKKVTF
	DRLQVLDDHY RDVLKEMKAK ASTVKAKLLS VEEACKLTPP HSAKSKFGYG AKDVRNLSSK
	AVNHIHSVWK DLLEDTVTPI DTTIMAKNEV FCVQPEKGGR KPARLIVFPD LGVRVCEKMA
	LYDVVSTLPQ VVMGSSYGFQ YSPGQRVEFL VNTWKSKKNP MGFSYDTRCF DSTVTENDIR
	VEESIYQCCD LAPEARQAIK SLTERLYIGG PLTNSKGQNC GYRRCRASGV LTTSCGNTLT
	CYLKASAACR AAKLQDCTML VNGDDLVVIC ESAGTQEDAA SLRVFTEAMT RYSAPPGDPP
	QPEYDLELIT SCSSNVSVAH DASGKRVYYL TRDPTTPLAR AAWETARHTP VNSWLGNIIM
	YAPTLWARMI LMTHFFSILL AQEQLEKALD CQIYGACYSI EPLDLPQIIE RLHGLSAFSL
	HSYSPGEINR VASCLRKLGV PPLRVWRHRA RSVRARLLSQ GGRAATCGKY LFNWAVKTKL
	KLTPIPAASR LDLSGWFVAG YSGGDIYHSL SRARPR
//