ID 3G5NA STANDARD; PRT; 476 AA. DT CONVERTED FROM PDB (SEQRES) 3G5N DE Cytochrome P450 2B4 OS Oryctolagus cuniculus CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.500 CC R-Factor 0.220 FT #SUB 11 30 LEU A 88 107 ILE B Protein S 1 FT #SUB 11 30 LEU A 89 108 PHE B Protein S 3 FT #SUB 17 36 PRO A 90 109 GLN B Protein S 1 FT #SUB 18 37 LEU A 268 287 ASN B Protein S 3 FT #SUB 19 38 PRO A 98 117 ASN B Protein S 2 FT #SUB 19 38 PRO A 101 120 ARG B Protein S 1 FT #SUB 21 40 LEU A 272 291 THR B Protein S 3 FT #SUB 24 43 LEU A 210 229 GLY B Protein S 1 FT #SUB 24 43 LEU A 216 235 TYR B Protein A 3 FT #SUB 25 44 LEU A 219 238 LEU B Protein S 1 FT #SUB 25 44 LEU A 268 287 ASN B Protein S 3 FT #SUB 25 44 LEU A 271 290 LEU B Protein S 1 FT #SUB 27 46 MET A 216 235 TYR B Protein A 6 FT #SUB 28 47 ASP A 216 235 TYR B Protein B 1 FT #SUB 29 48 ARG A 213 232 ARG B Protein B 3 FT #SUB 29 48 ARG A 216 235 TYR B Protein B 1 FT #SUB 30 49 LYS A 213 232 ARG B Protein B 1 FT #SUB 31 50 GLY A 213 232 ARG B Protein B 2 FT #SUB 32 51 LEU A 210 229 GLY B Protein S 1 FT #SUB 32 51 LEU A 211 230 THR B Protein S 2 FT #SUB 48 67 THR A 89 108 PHE B Protein S 1 FT #SUB 50 69 TYR A 89 108 PHE B Protein S 5 FT #SUB 50 69 TYR A 90 109 GLN B Protein S 5 FT #SUB 51 70 LEU A 208 227 PHE B Protein A 8 FT #SUB 52 71 GLY A 82 101 ILE B Protein B 2 FT #SUB 52 71 GLY A 208 227 PHE B Protein B 1 FT #SUB 53 72 SER A 82 101 ILE B Protein A 4 FT #SUB 53 72 SER A 83 102 ALA B Protein S 3 FT #SUB 53 72 SER A 84 103 VAL B Protein A 3 FT #SUB 53 72 SER A 85 104 VAL B Protein S 2 FT #SUB 53 72 SER A 90 109 GLN B Protein B 1 FT #SUB 54 73 ARG A 81 100 LYS B Protein S 2 FT #SUB 54 73 ARG A 82 101 ILE B Protein S 1 FT #SUB 54 73 ARG A 84 103 VAL B Protein S 4 FT #SUB 54 73 ARG A 86 105 ASP B Protein S 4 FT #SUB 55 74 PRO A 89 108 PHE B Protein S 8 FT #SUB 79 98 ARG A 201 220 PHE B Protein S 12 FT #SUB 79 98 ARG A 202 221 SER B Protein A 3 FT #SUB 80 99 GLY A 202 221 SER B Protein B 2 FT #SUB 80 99 GLY A 203 222 GLY B Protein B 11 FT #SUB 80 99 GLY A 204 223 PHE B Protein B 5 FT #SUB 81 100 LYS A 54 73 ARG B Protein B 2 FT #SUB 81 100 LYS A 203 222 GLY B Protein B 1 FT #SUB 82 101 ILE A 52 71 GLY B Protein A 3 FT #SUB 82 101 ILE A 53 72 SER B Protein B 5 FT #SUB 82 101 ILE A 54 73 ARG B Protein B 1 FT #SUB 82 101 ILE A 200 219 LEU B Protein S 1 FT #SUB 82 101 ILE A 203 222 GLY B Protein A 7 FT #SUB 82 101 ILE A 205 224 LEU B Protein S 2 FT #SUB 83 102 ALA A 53 72 SER B Protein B 4 FT #SUB 83 102 ALA A 200 219 LEU B Protein A 2 FT #SUB 83 102 ALA A 201 220 PHE B Protein S 1 FT #SUB 83 102 ALA A 203 222 GLY B Protein A 3 FT #SUB 84 103 VAL A 53 72 SER B Protein B 5 FT #SUB 84 103 VAL A 54 73 ARG B Protein B 4 FT #SUB 85 104 VAL A 53 72 SER B Protein B 1 FT #SUB 85 104 VAL A 54 73 ARG B Protein B 1 FT #SUB 86 105 ASP A 54 73 ARG B Protein A 4 FT #SUB 88 107 ILE A 11 30 LEU B Protein B 1 FT #SUB 88 107 ILE A 364 383 PRO B Protein S 1 FT #SUB 89 108 PHE A 11 30 LEU B Protein A 3 FT #SUB 89 108 PHE A 48 67 THR B Protein S 1 FT #SUB 89 108 PHE A 50 69 TYR B Protein A 6 FT #SUB 89 108 PHE A 55 74 PRO B Protein S 11 FT #SUB 89 108 PHE A 364 383 PRO B Protein S 3 FT #SUB 89 108 PHE A 367 386 THR B Protein S 3 FT #SUB 90 109 GLN A 17 36 PRO B Protein S 1 FT #SUB 90 109 GLN A 50 69 TYR B Protein S 6 FT #SUB 90 109 GLN A 53 72 SER B Protein S 1 FT #SUB 98 117 ASN A 19 38 PRO B Protein S 2 FT #SUB 101 120 ARG A 19 38 PRO B Protein S 1 FT #SUB 102 121 TRP A 201 220 PHE B Protein S 2 FT #SUB 182 201 LEU A 193 212 PHE B Protein B 1 FT #SUB 183 202 PHE A 192 211 SER B Protein B 2 FT #SUB 183 202 PHE A 193 212 PHE B Protein A 4 FT #SUB 183 202 PHE A 194 213 SER B Protein B 3 FT #SUB 185 204 GLN A 191 210 SER B Protein B 1 FT #SUB 186 205 SER A 190 209 ILE B Protein S 2 FT #SUB 186 205 SER A 191 210 SER B Protein B 2 FT #SUB 187 206 PHE A 189 208 LEU B Protein B 1 FT #SUB 187 206 PHE A 190 209 ILE B Protein B 2 FT #SUB 187 206 PHE A 191 210 SER B Protein A 8 FT #SUB 187 206 PHE A 192 211 SER B Protein S 2 FT #SUB 187 206 PHE A 193 212 PHE B Protein S 1 FT #SUB 187 206 PHE A 196 215 GLN B Protein S 4 FT #SUB 188 207 SER A 188 207 SER B Protein S 3 FT #SUB 188 207 SER A 189 208 LEU B Protein A 3 FT #SUB 189 208 LEU A 187 206 PHE B Protein B 1 FT #SUB 189 208 LEU A 188 207 SER B Protein B 3 FT #SUB 189 208 LEU A 189 208 LEU B Protein B 5 FT #SUB 190 209 ILE A 186 205 SER B Protein S 2 FT #SUB 190 209 ILE A 187 206 PHE B Protein B 2 FT #SUB 190 209 ILE A 455 474 GLU B Protein S 5 FT #SUB 191 210 SER A 185 204 GLN B Protein B 1 FT #SUB 191 210 SER A 186 205 SER B Protein B 2 FT #SUB 191 210 SER A 187 206 PHE B Protein A 12 FT #SUB 191 210 SER A 207 226 TYR B Protein S 1 FT #SUB 192 211 SER A 183 202 PHE B Protein S 2 FT #SUB 192 211 SER A 185 204 GLN B Protein B 1 FT #SUB 192 211 SER A 187 206 PHE B Protein B 3 FT #SUB 193 212 PHE A 182 201 LEU B Protein A 3 FT #SUB 193 212 PHE A 183 202 PHE B Protein A 4 FT #SUB 193 212 PHE A 187 206 PHE B Protein B 1 FT #SUB 193 212 PHE A 215 234 ILE B Protein S 2 FT #SUB 193 212 PHE A 275 294 SER B Protein S 1 FT #SUB 194 213 SER A 183 202 PHE B Protein A 5 FT #SUB 194 213 SER A 275 294 SER B Protein S 1 FT #SUB 194 213 SER A 279 298 ALA B Protein A 5 FT #SUB 196 215 GLN A 187 206 PHE B Protein S 5 FT #SUB 196 215 GLN A 207 226 TYR B Protein S 4 FT #SUB 196 215 GLN A 209 228 PRO B Protein A 8 FT #SUB 196 215 GLN A 210 229 GLY B Protein S 3 FT #SUB 196 215 GLN A 215 234 ILE B Protein S 1 FT #SUB 197 216 VAL A 275 294 SER B Protein S 6 FT #SUB 197 216 VAL A 276 295 LEU B Protein S 1 FT #SUB 198 217 PHE A 276 295 LEU B Protein A 2 FT #SUB 198 217 PHE A 279 298 ALA B Protein S 1 FT #SUB 199 218 GLU A 207 226 TYR B Protein S 5 FT #SUB 200 219 LEU A 82 101 ILE B Protein S 1 FT #SUB 200 219 LEU A 83 102 ALA B Protein B 1 FT #SUB 200 219 LEU A 208 227 PHE B Protein S 2 FT #SUB 200 219 LEU A 209 228 PRO B Protein S 2 FT #SUB 201 220 PHE A 79 98 ARG B Protein A 8 FT #SUB 201 220 PHE A 83 102 ALA B Protein B 1 FT #SUB 201 220 PHE A 102 121 TRP B Protein S 3 FT #SUB 201 220 PHE A 276 295 LEU B Protein S 2 FT #SUB 202 221 SER A 79 98 ARG B Protein B 3 FT #SUB 202 221 SER A 80 99 GLY B Protein B 1 FT #SUB 202 221 SER A 348 367 VAL B Protein S 1 FT #SUB 203 222 GLY A 80 99 GLY B Protein B 9 FT #SUB 203 222 GLY A 81 100 LYS B Protein B 1 FT #SUB 203 222 GLY A 82 101 ILE B Protein B 7 FT #SUB 203 222 GLY A 83 102 ALA B Protein B 3 FT #SUB 204 223 PHE A 80 99 GLY B Protein S 6 FT #SUB 204 223 PHE A 349 368 PRO B Protein S 12 FT #SUB 204 223 PHE A 350 369 HIS B Protein S 4 FT #SUB 204 223 PHE A 368 387 GLU B Protein S 5 FT #SUB 205 224 LEU A 82 101 ILE B Protein S 2 FT #SUB 205 224 LEU A 207 226 TYR B Protein S 2 FT #SUB 205 224 LEU A 208 227 PHE B Protein S 1 FT #SUB 205 224 LEU A 209 228 PRO B Protein S 1 FT #SUB 206 225 LYS A 458 477 VAL B Protein S 3 FT #SUB 207 226 TYR A 191 210 SER B Protein S 1 FT #SUB 207 226 TYR A 196 215 GLN B Protein S 3 FT #SUB 207 226 TYR A 199 218 GLU B Protein S 5 FT #SUB 207 226 TYR A 205 224 LEU B Protein A 2 FT #SUB 207 226 TYR A 207 226 TYR B Protein S 10 FT #SUB 208 227 PHE A 51 70 LEU B Protein S 10 FT #SUB 208 227 PHE A 52 71 GLY B Protein S 1 FT #SUB 208 227 PHE A 200 219 LEU B Protein S 2 FT #SUB 208 227 PHE A 205 224 LEU B Protein S 1 FT #SUB 209 228 PRO A 196 215 GLN B Protein A 8 FT #SUB 209 228 PRO A 200 219 LEU B Protein S 2 FT #SUB 209 228 PRO A 205 224 LEU B Protein S 1 FT #SUB 210 229 GLY A 24 43 LEU B Protein B 1 FT #SUB 210 229 GLY A 32 51 LEU B Protein B 1 FT #SUB 210 229 GLY A 196 215 GLN B Protein B 2 FT #SUB 211 230 THR A 32 51 LEU B Protein A 2 FT #SUB 211 230 THR A 457 476 GLY B Protein B 1 FT #SUB 215 234 ILE A 193 212 PHE B Protein S 1 FT #SUB 215 234 ILE A 196 215 GLN B Protein S 1 FT #SUB 216 235 TYR A 24 43 LEU B Protein S 2 FT #SUB 216 235 TYR A 27 46 MET B Protein S 6 FT #SUB 216 235 TYR A 28 47 ASP B Protein S 2 FT #SUB 216 235 TYR A 29 48 ARG B Protein S 1 FT #SUB 264 283 PHE A 18 37 LEU B Protein B 3 FT #SUB 265 284 HIS A 18 37 LEU B Protein B 1 FT #SUB 265 284 HIS A 19 38 PRO B Protein S 3 FT #SUB 268 287 ASN A 18 37 LEU B Protein S 4 FT #SUB 268 287 ASN A 25 44 LEU B Protein S 3 FT #SUB 269 288 LEU A 18 37 LEU B Protein S 1 FT #SUB 271 290 LEU A 25 44 LEU B Protein S 2 FT #SUB 272 291 THR A 21 40 LEU B Protein S 3 FT #SUB 275 294 SER A 193 212 PHE B Protein S 2 FT #SUB 275 294 SER A 194 213 SER B Protein B 1 FT #SUB 275 294 SER A 197 216 VAL B Protein S 4 FT #SUB 276 295 LEU A 197 216 VAL B Protein S 1 FT #SUB 276 295 LEU A 198 217 PHE B Protein S 2 FT #SUB 276 295 LEU A 201 220 PHE B Protein S 1 FT #SUB 278 297 PHE A 194 213 SER B Protein B 1 FT #SUB 279 298 ALA A 194 213 SER B Protein A 6 FT #SUB 279 298 ALA A 198 217 PHE B Protein S 1 FT #SUB 348 367 VAL A 198 217 PHE B Protein S 1 FT #SUB 348 367 VAL A 202 221 SER B Protein S 1 FT #SUB 349 368 PRO A 204 223 PHE B Protein A 12 FT #SUB 350 369 HIS A 204 223 PHE B Protein B 6 FT #SUB 364 383 PRO A 88 107 ILE B Protein S 1 FT #SUB 364 383 PRO A 89 108 PHE B Protein S 3 FT #SUB 367 386 THR A 89 108 PHE B Protein S 1 FT #SUB 368 387 GLU A 204 223 PHE B Protein S 6 FT #SUB 454 473 ARG A 213 232 ARG B Protein B 1 FT #SUB 455 474 GLU A 213 232 ARG B Protein B 4 FT #SUB 456 475 SER A 213 232 ARG B Protein S 7 FT #SUB 457 476 GLY A 211 230 THR B Protein B 1 FT #SUB 458 477 VAL A 206 225 LYS B Protein S 1 FT #SUB 9 28 GLY A 92 111 TYR C Protein B 1 FT #SUB 92 111 TYR A 355 374 ASP C Protein S 3 FT #SUB 92 111 TYR A 362 381 VAL C Protein S 1 FT #SUB 92 111 TYR A 364 383 PRO C Protein S 2 FT #SUB 96 115 PHE A 357 376 GLN C Protein S 13 FT #SUB 96 115 PHE A 362 381 VAL C Protein S 1 FT #SUB 355 374 ASP A 92 111 TYR C Protein S 3 FT #SUB 357 376 GLN A 96 115 PHE C Protein S 12 FT #SUB 357 376 GLN A 100 119 GLU C Protein S 2 FT #SUB 362 381 VAL A 92 111 TYR C Protein S 4 FT #SUB 362 381 VAL A 96 115 PHE C Protein S 3 FT #SUB 364 383 PRO A 92 111 TYR C Protein S 4 FT #SUB 365 384 LYS A 365 384 LYS C Protein S 4 FT #SUB 88 107 ILE A 88 107 ILE D Protein S 1 FT #SUB 88 107 ILE A 92 111 TYR D Protein S 2 FT #SUB 92 111 TYR A 88 107 ILE D Protein S 2 FT #HET 20 39 VAL A 10 504 CM5 B S 1 FT #HET 23 42 ASN A 5 502 PB2 B B 1 FT #HET 24 43 LEU A 5 502 PB2 B A 6 FT #HET 27 46 MET A 5 502 PB2 B S 1 FT #HET 50 69 TYR A 5 502 PB2 B B 2 FT #HET 51 70 LEU A 3 503 PB2 A S 2 FT #HET 51 70 LEU A 5 502 PB2 B S 6 FT #HET 54 73 ARG A 3 503 PB2 A S 4 FT #HET 79 98 ARG A 1 500 HEM A S 1 FT #HET 79 98 ARG A 4 504 CM5 A S 8 FT #HET 95 114 ILE A 4 504 CM5 A B 1 FT #HET 98 117 ASN A 4 504 CM5 A A 4 FT #HET 99 118 GLY A 4 504 CM5 A B 2 FT #HET 102 121 TRP A 1 500 HEM A S 3 FT #HET 102 121 TRP A 4 504 CM5 A S 1 FT #HET 106 125 ARG A 1 500 HEM A S 3 FT #HET 198 217 PHE A 7 500 HEM B S 6 FT #HET 198 217 PHE A 8 501 PB2 B S 10 FT #HET 199 218 GLU A 8 501 PB2 B S 2 FT #HET 201 220 PHE A 7 500 HEM B S 1 FT #HET 201 220 PHE A 10 504 CM5 B S 1 FT #HET 204 223 PHE A 8 501 PB2 B B 1 FT #HET 205 224 LEU A 6 496 PB2 B B 1 FT #HET 205 224 LEU A 9 503 PB2 B B 3 FT #HET 206 225 LYS A 6 496 PB2 B B 2 FT #HET 208 227 PHE A 6 496 PB2 B S 2 FT #HET 209 228 PRO A 6 496 PB2 B B 1 FT #HET 211 230 THR A 6 496 PB2 B S 3 FT #HET 269 288 LEU A 4 504 CM5 A S 1 FT #HET 272 291 THR A 4 504 CM5 A S 1 FT #HET 273 292 VAL A 4 504 CM5 A S 1 FT #HET 277 296 PHE A 1 500 HEM A A 8 FT #HET 279 298 ALA A 2 501 PB2 A A 6 FT #HET 280 299 GLY A 1 500 HEM A B 16 FT #HET 280 299 GLY A 2 501 PB2 A B 8 FT #HET 281 300 THR A 1 500 HEM A B 2 FT #HET 283 302 THR A 1 500 HEM A S 7 FT #HET 283 302 THR A 2 501 PB2 A S 3 FT #HET 284 303 THR A 1 500 HEM A A 4 FT #HET 287 306 THR A 1 500 HEM A S 1 FT #HET 338 357 GLN A 1 500 HEM A S 1 FT #HET 344 363 ILE A 1 500 HEM A S 5 FT #HET 344 363 ILE A 2 501 PB2 A S 2 FT #HET 346 365 PHE A 5 502 PB2 B S 1 FT #HET 347 366 GLY A 2 501 PB2 A B 1 FT #HET 348 367 VAL A 1 500 HEM A S 3 FT #HET 348 367 VAL A 2 501 PB2 A S 1 FT #HET 349 368 PRO A 2 501 PB2 A S 3 FT #HET 349 368 PRO A 5 502 PB2 B S 1 FT #HET 350 369 HIS A 1 500 HEM A S 7 FT #HET 368 387 GLU A 3 503 PB2 A S 9 FT #HET 370 389 PHE A 5 502 PB2 B S 5 FT #HET 373 392 LEU A 1 500 HEM A S 1 FT #HET 409 428 PRO A 1 500 HEM A B 3 FT #HET 410 429 PHE A 1 500 HEM A A 15 FT #HET 411 430 SER A 1 500 HEM A S 5 FT #HET 415 434 ARG A 1 500 HEM A A 18 FT #HET 415 434 ARG A 4 504 CM5 A S 1 FT #HET 417 436 CYS A 1 500 HEM A A 26 FT #HET 418 437 LEU A 1 500 HEM A A 8 FT #HET 419 438 GLY A 1 500 HEM A B 6 FT #HET 423 442 ALA A 1 500 HEM A S 1 FT #HET 458 477 VAL A 5 502 PB2 B S 3 FT DISORDER 1 7 FT DISORDER 116 119 FT DISORDER 257 263 FT DISORDER 475 476 CC SEQUENCE 456 AA (ATOM); CC KGKLPPGPSP LPVLGNLLQM DRKGLLRSFL RLREKYGDVF TVYLGSRPVV VLCGTDAIRE CC ALVDQAEAFS GRGKIAVVDP IFQGYGVIFA NGERWRALRR FSLATMRDKR SVEERIQEEA CC RCLVEELRKS KGALLDNTLL FHSITSNIIC SIVFGKRFDY KDPVFLRLLD LFFQSFSLIS CC SFSSQVFELF SGFLKYFPGT HRQIYRNLQE INTFIGQSVE KHRATLDPSN PRDFIDVYLL CC RMEKDFHHQN LILTVLSLFF AGTETTSTTL RYGFLLMLKY PHVTERVQKE IEQVIGSHRP CC PALDDRAKMP YTDAVIHEIQ RLGDLIPFGV PHTVTKDTQF RGYVIPKNTE VFPVLSSALH CC DPRYFETPNT FNPGHFLDAN GALKRNEGFM PFSLGKRICL GEGIARTELF LFFTTILQNF CC SIASPVPPED IDLTPRESGV GNVPPSYQIR FLARHH CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVY CC ATOM -------KGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVY CC ******************************************* CC SEQRES LGSRPVVVLCGTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGE CC ATOM LGSRPVVVLCGTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGE CC ************************************************** CC SEQRES RWRALRRFSLATMRDFGMGKRSVEERIQEEARCLVEELRKSKGALLDNTL CC ATOM RWRALRRFSLATMRD----KRSVEERIQEEARCLVEELRKSKGALLDNTL CC *************** ******************************* CC SEQRES LFHSITSNIICSIVFGKRFDYKDPVFLRLLDLFFQSFSLISSFSSQVFEL CC ATOM LFHSITSNIICSIVFGKRFDYKDPVFLRLLDLFFQSFSLISSFSSQVFEL CC ************************************************** CC SEQRES FSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPSNPRDFIDVYL CC ATOM FSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPSNPRDFIDVYL CC ************************************************** CC SEQRES LRMEKDKSDPSSEFHHQNLILTVLSLFFAGTETTSTTLRYGFLLMLKYPH CC ATOM LRMEKD-------FHHQNLILTVLSLFFAGTETTSTTLRYGFLLMLKYPH CC ****** ************************************* CC SEQRES VTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPH CC ATOM VTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPH CC ************************************************** CC SEQRES TVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGA CC ATOM TVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGA CC ************************************************** CC SEQRES LKRNEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDID CC ATOM LKRNEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDID CC ************************************************** CC SEQRES LTPRESGVGNVPPSYQIRFLARHHHH CC ATOM LTPRESGVGNVPPSYQIRFLARHH-- CC ************************ SQ SEQUENCE 476 AA; MW; CN; MAKKTSSKGK LPPGPSPLPV LGNLLQMDRK GLLRSFLRLR EKYGDVFTVY LGSRPVVVLC GTDAIREALV DQAEAFSGRG KIAVVDPIFQ GYGVIFANGE RWRALRRFSL ATMRDFGMGK RSVEERIQEE ARCLVEELRK SKGALLDNTL LFHSITSNII CSIVFGKRFD YKDPVFLRLL DLFFQSFSLI SSFSSQVFEL FSGFLKYFPG THRQIYRNLQ EINTFIGQSV EKHRATLDPS NPRDFIDVYL LRMEKDKSDP SSEFHHQNLI LTVLSLFFAG TETTSTTLRY GFLLMLKYPH VTERVQKEIE QVIGSHRPPA LDDRAKMPYT DAVIHEIQRL GDLIPFGVPH TVTKDTQFRG YVIPKNTEVF PVLSSALHDP RYFETPNTFN PGHFLDANGA LKRNEGFMPF SLGKRICLGE GIARTELFLF FTTILQNFSI ASPVPPEDID LTPRESGVGN VPPSYQIRFL ARHHHH // ID 3G5NB STANDARD; PRT; 476 AA. DT CONVERTED FROM PDB (SEQRES) 3G5N DE Cytochrome P450 2B4 OS Oryctolagus cuniculus CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.500 CC R-Factor 0.220 FT #SUB 11 30 LEU B 88 107 ILE A Protein S 1 FT #SUB 11 30 LEU B 89 108 PHE A Protein S 3 FT #SUB 17 36 PRO B 90 109 GLN A Protein S 1 FT #SUB 18 37 LEU B 264 283 PHE A Protein S 3 FT #SUB 18 37 LEU B 265 284 HIS A Protein S 1 FT #SUB 18 37 LEU B 268 287 ASN A Protein S 4 FT #SUB 18 37 LEU B 269 288 LEU A Protein S 1 FT #SUB 19 38 PRO B 98 117 ASN A Protein S 2 FT #SUB 19 38 PRO B 101 120 ARG A Protein S 1 FT #SUB 19 38 PRO B 265 284 HIS A Protein S 3 FT #SUB 21 40 LEU B 272 291 THR A Protein S 3 FT #SUB 24 43 LEU B 210 229 GLY A Protein S 1 FT #SUB 24 43 LEU B 216 235 TYR A Protein A 2 FT #SUB 25 44 LEU B 268 287 ASN A Protein S 3 FT #SUB 25 44 LEU B 271 290 LEU A Protein S 2 FT #SUB 27 46 MET B 216 235 TYR A Protein A 6 FT #SUB 28 47 ASP B 216 235 TYR A Protein B 2 FT #SUB 29 48 ARG B 216 235 TYR A Protein B 1 FT #SUB 32 51 LEU B 210 229 GLY A Protein S 1 FT #SUB 32 51 LEU B 211 230 THR A Protein S 2 FT #SUB 48 67 THR B 89 108 PHE A Protein S 1 FT #SUB 50 69 TYR B 89 108 PHE A Protein S 6 FT #SUB 50 69 TYR B 90 109 GLN A Protein S 6 FT #SUB 51 70 LEU B 208 227 PHE A Protein A 10 FT #SUB 52 71 GLY B 82 101 ILE A Protein B 3 FT #SUB 52 71 GLY B 208 227 PHE A Protein B 1 FT #SUB 53 72 SER B 82 101 ILE A Protein A 5 FT #SUB 53 72 SER B 83 102 ALA A Protein S 4 FT #SUB 53 72 SER B 84 103 VAL A Protein A 5 FT #SUB 53 72 SER B 85 104 VAL A Protein S 1 FT #SUB 53 72 SER B 90 109 GLN A Protein B 1 FT #SUB 54 73 ARG B 81 100 LYS A Protein S 2 FT #SUB 54 73 ARG B 82 101 ILE A Protein S 1 FT #SUB 54 73 ARG B 84 103 VAL A Protein S 4 FT #SUB 54 73 ARG B 85 104 VAL A Protein S 1 FT #SUB 54 73 ARG B 86 105 ASP A Protein S 4 FT #SUB 55 74 PRO B 89 108 PHE A Protein S 11 FT #SUB 79 98 ARG B 201 220 PHE A Protein S 8 FT #SUB 79 98 ARG B 202 221 SER A Protein A 3 FT #SUB 80 99 GLY B 202 221 SER A Protein B 1 FT #SUB 80 99 GLY B 203 222 GLY A Protein B 9 FT #SUB 80 99 GLY B 204 223 PHE A Protein B 6 FT #SUB 81 100 LYS B 54 73 ARG A Protein B 2 FT #SUB 81 100 LYS B 203 222 GLY A Protein B 1 FT #SUB 82 101 ILE B 52 71 GLY A Protein B 2 FT #SUB 82 101 ILE B 53 72 SER A Protein B 4 FT #SUB 82 101 ILE B 54 73 ARG A Protein B 1 FT #SUB 82 101 ILE B 200 219 LEU A Protein S 1 FT #SUB 82 101 ILE B 203 222 GLY A Protein A 7 FT #SUB 82 101 ILE B 205 224 LEU A Protein S 2 FT #SUB 83 102 ALA B 53 72 SER A Protein B 3 FT #SUB 83 102 ALA B 200 219 LEU A Protein S 1 FT #SUB 83 102 ALA B 201 220 PHE A Protein S 1 FT #SUB 83 102 ALA B 203 222 GLY A Protein A 3 FT #SUB 84 103 VAL B 53 72 SER A Protein B 3 FT #SUB 84 103 VAL B 54 73 ARG A Protein B 4 FT #SUB 85 104 VAL B 53 72 SER A Protein B 2 FT #SUB 86 105 ASP B 54 73 ARG A Protein A 4 FT #SUB 88 107 ILE B 11 30 LEU A Protein B 1 FT #SUB 88 107 ILE B 364 383 PRO A Protein S 1 FT #SUB 89 108 PHE B 11 30 LEU A Protein A 3 FT #SUB 89 108 PHE B 48 67 THR A Protein S 1 FT #SUB 89 108 PHE B 50 69 TYR A Protein A 5 FT #SUB 89 108 PHE B 55 74 PRO A Protein S 8 FT #SUB 89 108 PHE B 364 383 PRO A Protein S 3 FT #SUB 89 108 PHE B 367 386 THR A Protein S 1 FT #SUB 90 109 GLN B 17 36 PRO A Protein S 1 FT #SUB 90 109 GLN B 50 69 TYR A Protein S 5 FT #SUB 90 109 GLN B 53 72 SER A Protein S 1 FT #SUB 98 117 ASN B 19 38 PRO A Protein S 2 FT #SUB 101 120 ARG B 19 38 PRO A Protein S 1 FT #SUB 102 121 TRP B 201 220 PHE A Protein S 3 FT #SUB 182 201 LEU B 193 212 PHE A Protein A 3 FT #SUB 183 202 PHE B 192 211 SER A Protein B 2 FT #SUB 183 202 PHE B 193 212 PHE A Protein A 4 FT #SUB 183 202 PHE B 194 213 SER A Protein A 5 FT #SUB 185 204 GLN B 191 210 SER A Protein B 1 FT #SUB 185 204 GLN B 192 211 SER A Protein B 1 FT #SUB 186 205 SER B 190 209 ILE A Protein S 2 FT #SUB 186 205 SER B 191 210 SER A Protein B 2 FT #SUB 187 206 PHE B 189 208 LEU A Protein B 1 FT #SUB 187 206 PHE B 190 209 ILE A Protein B 2 FT #SUB 187 206 PHE B 191 210 SER A Protein A 12 FT #SUB 187 206 PHE B 192 211 SER A Protein S 3 FT #SUB 187 206 PHE B 193 212 PHE A Protein S 1 FT #SUB 187 206 PHE B 196 215 GLN A Protein S 5 FT #SUB 188 207 SER B 188 207 SER A Protein S 3 FT #SUB 188 207 SER B 189 208 LEU A Protein A 3 FT #SUB 189 208 LEU B 187 206 PHE A Protein B 1 FT #SUB 189 208 LEU B 188 207 SER A Protein B 3 FT #SUB 189 208 LEU B 189 208 LEU A Protein A 5 FT #SUB 190 209 ILE B 186 205 SER A Protein S 2 FT #SUB 190 209 ILE B 187 206 PHE A Protein B 2 FT #SUB 191 210 SER B 185 204 GLN A Protein B 1 FT #SUB 191 210 SER B 186 205 SER A Protein B 2 FT #SUB 191 210 SER B 187 206 PHE A Protein A 8 FT #SUB 191 210 SER B 207 226 TYR A Protein S 1 FT #SUB 192 211 SER B 183 202 PHE A Protein S 2 FT #SUB 192 211 SER B 187 206 PHE A Protein B 2 FT #SUB 193 212 PHE B 182 201 LEU A Protein S 1 FT #SUB 193 212 PHE B 183 202 PHE A Protein A 4 FT #SUB 193 212 PHE B 187 206 PHE A Protein B 1 FT #SUB 193 212 PHE B 215 234 ILE A Protein S 1 FT #SUB 193 212 PHE B 275 294 SER A Protein S 2 FT #SUB 194 213 SER B 183 202 PHE A Protein A 3 FT #SUB 194 213 SER B 275 294 SER A Protein S 1 FT #SUB 194 213 SER B 278 297 PHE A Protein S 1 FT #SUB 194 213 SER B 279 298 ALA A Protein A 6 FT #SUB 196 215 GLN B 187 206 PHE A Protein S 4 FT #SUB 196 215 GLN B 207 226 TYR A Protein S 3 FT #SUB 196 215 GLN B 209 228 PRO A Protein A 8 FT #SUB 196 215 GLN B 210 229 GLY A Protein S 2 FT #SUB 196 215 GLN B 215 234 ILE A Protein S 1 FT #SUB 197 216 VAL B 275 294 SER A Protein S 4 FT #SUB 197 216 VAL B 276 295 LEU A Protein S 1 FT #SUB 198 217 PHE B 276 295 LEU A Protein A 2 FT #SUB 198 217 PHE B 279 298 ALA A Protein S 1 FT #SUB 198 217 PHE B 348 367 VAL A Protein S 1 FT #SUB 199 218 GLU B 207 226 TYR A Protein S 5 FT #SUB 200 219 LEU B 82 101 ILE A Protein S 1 FT #SUB 200 219 LEU B 83 102 ALA A Protein B 2 FT #SUB 200 219 LEU B 208 227 PHE A Protein S 2 FT #SUB 200 219 LEU B 209 228 PRO A Protein S 2 FT #SUB 201 220 PHE B 79 98 ARG A Protein A 12 FT #SUB 201 220 PHE B 83 102 ALA A Protein B 1 FT #SUB 201 220 PHE B 102 121 TRP A Protein S 2 FT #SUB 201 220 PHE B 276 295 LEU A Protein S 1 FT #SUB 202 221 SER B 79 98 ARG A Protein B 3 FT #SUB 202 221 SER B 80 99 GLY A Protein B 2 FT #SUB 202 221 SER B 348 367 VAL A Protein S 1 FT #SUB 203 222 GLY B 80 99 GLY A Protein B 11 FT #SUB 203 222 GLY B 81 100 LYS A Protein B 1 FT #SUB 203 222 GLY B 82 101 ILE A Protein B 7 FT #SUB 203 222 GLY B 83 102 ALA A Protein B 3 FT #SUB 204 223 PHE B 80 99 GLY A Protein S 5 FT #SUB 204 223 PHE B 349 368 PRO A Protein S 12 FT #SUB 204 223 PHE B 350 369 HIS A Protein S 6 FT #SUB 204 223 PHE B 368 387 GLU A Protein S 6 FT #SUB 205 224 LEU B 82 101 ILE A Protein S 2 FT #SUB 205 224 LEU B 207 226 TYR A Protein S 2 FT #SUB 205 224 LEU B 208 227 PHE A Protein S 1 FT #SUB 205 224 LEU B 209 228 PRO A Protein S 1 FT #SUB 206 225 LYS B 458 477 VAL A Protein S 1 FT #SUB 207 226 TYR B 191 210 SER A Protein S 1 FT #SUB 207 226 TYR B 196 215 GLN A Protein S 4 FT #SUB 207 226 TYR B 199 218 GLU A Protein S 5 FT #SUB 207 226 TYR B 205 224 LEU A Protein A 2 FT #SUB 207 226 TYR B 207 226 TYR A Protein A 10 FT #SUB 208 227 PHE B 51 70 LEU A Protein S 8 FT #SUB 208 227 PHE B 52 71 GLY A Protein S 1 FT #SUB 208 227 PHE B 200 219 LEU A Protein S 2 FT #SUB 208 227 PHE B 205 224 LEU A Protein S 1 FT #SUB 209 228 PRO B 196 215 GLN A Protein A 8 FT #SUB 209 228 PRO B 200 219 LEU A Protein S 2 FT #SUB 209 228 PRO B 205 224 LEU A Protein S 1 FT #SUB 210 229 GLY B 24 43 LEU A Protein B 1 FT #SUB 210 229 GLY B 32 51 LEU A Protein B 1 FT #SUB 210 229 GLY B 196 215 GLN A Protein B 3 FT #SUB 211 230 THR B 32 51 LEU A Protein A 2 FT #SUB 211 230 THR B 457 476 GLY A Protein B 1 FT #SUB 213 232 ARG B 29 48 ARG A Protein S 3 FT #SUB 213 232 ARG B 30 49 LYS A Protein S 1 FT #SUB 213 232 ARG B 31 50 GLY A Protein S 2 FT #SUB 213 232 ARG B 454 473 ARG A Protein S 1 FT #SUB 213 232 ARG B 455 474 GLU A Protein S 4 FT #SUB 213 232 ARG B 456 475 SER A Protein S 7 FT #SUB 215 234 ILE B 193 212 PHE A Protein S 2 FT #SUB 215 234 ILE B 196 215 GLN A Protein S 1 FT #SUB 216 235 TYR B 24 43 LEU A Protein S 3 FT #SUB 216 235 TYR B 27 46 MET A Protein S 6 FT #SUB 216 235 TYR B 28 47 ASP A Protein S 1 FT #SUB 216 235 TYR B 29 48 ARG A Protein S 1 FT #SUB 219 238 LEU B 25 44 LEU A Protein S 1 FT #SUB 268 287 ASN B 18 37 LEU A Protein S 3 FT #SUB 268 287 ASN B 25 44 LEU A Protein S 3 FT #SUB 271 290 LEU B 25 44 LEU A Protein S 1 FT #SUB 272 291 THR B 21 40 LEU A Protein S 3 FT #SUB 275 294 SER B 193 212 PHE A Protein S 1 FT #SUB 275 294 SER B 194 213 SER A Protein B 1 FT #SUB 275 294 SER B 197 216 VAL A Protein S 6 FT #SUB 276 295 LEU B 197 216 VAL A Protein S 1 FT #SUB 276 295 LEU B 198 217 PHE A Protein S 2 FT #SUB 276 295 LEU B 201 220 PHE A Protein S 2 FT #SUB 279 298 ALA B 194 213 SER A Protein A 5 FT #SUB 279 298 ALA B 198 217 PHE A Protein S 1 FT #SUB 348 367 VAL B 202 221 SER A Protein S 1 FT #SUB 349 368 PRO B 204 223 PHE A Protein A 12 FT #SUB 350 369 HIS B 204 223 PHE A Protein B 4 FT #SUB 364 383 PRO B 88 107 ILE A Protein S 1 FT #SUB 364 383 PRO B 89 108 PHE A Protein S 3 FT #SUB 367 386 THR B 89 108 PHE A Protein S 3 FT #SUB 368 387 GLU B 204 223 PHE A Protein S 5 FT #SUB 455 474 GLU B 190 209 ILE A Protein S 5 FT #SUB 457 476 GLY B 211 230 THR A Protein B 1 FT #SUB 458 477 VAL B 206 225 LYS A Protein S 3 FT #SUB 88 107 ILE B 88 107 ILE C Protein S 1 FT #SUB 88 107 ILE B 92 111 TYR C Protein S 4 FT #SUB 92 111 TYR B 88 107 ILE C Protein S 3 FT #SUB 92 111 TYR B 355 374 ASP D Protein S 8 FT #SUB 92 111 TYR B 362 381 VAL D Protein S 4 FT #SUB 92 111 TYR B 364 383 PRO D Protein S 5 FT #SUB 96 115 PHE B 355 374 ASP D Protein S 4 FT #SUB 96 115 PHE B 356 375 THR D Protein S 1 FT #SUB 96 115 PHE B 357 376 GLN D Protein S 15 FT #SUB 96 115 PHE B 362 381 VAL D Protein S 1 FT #SUB 100 119 GLU B 357 376 GLN D Protein S 1 FT #SUB 355 374 ASP B 92 111 TYR D Protein S 6 FT #SUB 355 374 ASP B 96 115 PHE D Protein A 4 FT #SUB 356 375 THR B 96 115 PHE D Protein B 1 FT #SUB 357 376 GLN B 96 115 PHE D Protein S 14 FT #SUB 357 376 GLN B 100 119 GLU D Protein S 1 FT #SUB 362 381 VAL B 92 111 TYR D Protein S 4 FT #SUB 362 381 VAL B 96 115 PHE D Protein S 1 FT #SUB 364 383 PRO B 92 111 TYR D Protein S 5 FT #SUB 365 384 LYS B 365 384 LYS D Protein S 3 FT #HET 20 39 VAL B 4 504 CM5 A S 2 FT #HET 24 43 LEU B 6 496 PB2 B A 6 FT #HET 27 46 MET B 6 496 PB2 B S 1 FT #HET 32 51 LEU B 6 496 PB2 B S 3 FT #HET 36 55 PHE B 6 496 PB2 B S 1 FT #HET 50 69 TYR B 6 496 PB2 B B 1 FT #HET 51 70 LEU B 6 496 PB2 B S 4 FT #HET 51 70 LEU B 9 503 PB2 B A 2 FT #HET 54 73 ARG B 9 503 PB2 B S 4 FT #HET 79 98 ARG B 7 500 HEM B S 2 FT #HET 79 98 ARG B 10 504 CM5 B S 4 FT #HET 82 101 ILE B 3 503 PB2 A S 1 FT #HET 95 114 ILE B 10 504 CM5 B B 1 FT #HET 98 117 ASN B 10 504 CM5 B A 3 FT #HET 101 120 ARG B 10 504 CM5 B S 2 FT #HET 102 121 TRP B 7 500 HEM B S 5 FT #HET 106 125 ARG B 7 500 HEM B S 4 FT #HET 198 217 PHE B 1 500 HEM A S 5 FT #HET 198 217 PHE B 2 501 PB2 A S 10 FT #HET 199 218 GLU B 2 501 PB2 A S 2 FT #HET 201 220 PHE B 1 500 HEM A S 2 FT #HET 204 223 PHE B 2 501 PB2 A B 2 FT #HET 204 223 PHE B 3 503 PB2 A S 3 FT #HET 205 224 LEU B 3 503 PB2 A B 2 FT #HET 205 224 LEU B 5 502 PB2 B B 1 FT #HET 206 225 LYS B 2 501 PB2 A S 6 FT #HET 206 225 LYS B 5 502 PB2 B B 2 FT #HET 208 227 PHE B 5 502 PB2 B S 1 FT #HET 209 228 PRO B 5 502 PB2 B B 3 FT #HET 210 229 GLY B 5 502 PB2 B B 1 FT #HET 211 230 THR B 5 502 PB2 B S 5 FT #HET 269 288 LEU B 10 504 CM5 B S 2 FT #HET 272 291 THR B 10 504 CM5 B S 1 FT #HET 273 292 VAL B 10 504 CM5 B S 1 FT #HET 277 296 PHE B 7 500 HEM B A 5 FT #HET 279 298 ALA B 8 501 PB2 B A 7 FT #HET 280 299 GLY B 7 500 HEM B B 15 FT #HET 280 299 GLY B 8 501 PB2 B B 8 FT #HET 281 300 THR B 7 500 HEM B B 2 FT #HET 283 302 THR B 7 500 HEM B S 7 FT #HET 283 302 THR B 8 501 PB2 B S 3 FT #HET 284 303 THR B 7 500 HEM B A 5 FT #HET 287 306 THR B 7 500 HEM B S 1 FT #HET 338 357 GLN B 7 500 HEM B S 1 FT #HET 344 363 ILE B 7 500 HEM B S 5 FT #HET 344 363 ILE B 8 501 PB2 B S 2 FT #HET 346 365 PHE B 6 496 PB2 B S 1 FT #HET 347 366 GLY B 8 501 PB2 B B 1 FT #HET 348 367 VAL B 7 500 HEM B S 3 FT #HET 348 367 VAL B 8 501 PB2 B S 1 FT #HET 349 368 PRO B 6 496 PB2 B S 1 FT #HET 349 368 PRO B 8 501 PB2 B S 2 FT #HET 350 369 HIS B 7 500 HEM B S 7 FT #HET 368 387 GLU B 9 503 PB2 B S 6 FT #HET 370 389 PHE B 6 496 PB2 B S 7 FT #HET 370 389 PHE B 9 503 PB2 B S 2 FT #HET 373 392 LEU B 7 500 HEM B S 1 FT #HET 409 428 PRO B 7 500 HEM B B 3 FT #HET 410 429 PHE B 7 500 HEM B A 17 FT #HET 411 430 SER B 7 500 HEM B A 7 FT #HET 415 434 ARG B 7 500 HEM B A 18 FT #HET 416 435 ILE B 7 500 HEM B B 1 FT #HET 417 436 CYS B 7 500 HEM B A 27 FT #HET 418 437 LEU B 7 500 HEM B A 8 FT #HET 419 438 GLY B 7 500 HEM B B 8 FT #HET 423 442 ALA B 7 500 HEM B S 2 FT #HET 458 477 VAL B 6 496 PB2 B S 6 FT DISORDER 1 8 FT DISORDER 116 119 FT DISORDER 255 264 FT DISORDER 474 476 CC SEQUENCE 451 AA (ATOM); CC GKLPPGPSPL PVLGNLLQMD RKGLLRSFLR LREKYGDVFT VYLGSRPVVV LCGTDAIREA CC LVDQAEAFSG RGKIAVVDPI FQGYGVIFAN GERWRALRRF SLATMRDKRS VEERIQEEAR CC CLVEELRKSK GALLDNTLLF HSITSNIICS IVFGKRFDYK DPVFLRLLDL FFQSFSLISS CC FSSQVFELFS GFLKYFPGTH RQIYRNLQEI NTFIGQSVEK HRATLDPSNP RDFIDVYLLR CC MEHHQNLILT VLSLFFAGTE TTSTTLRYGF LLMLKYPHVT ERVQKEIEQV IGSHRPPALD CC DRAKMPYTDA VIHEIQRLGD LIPFGVPHTV TKDTQFRGYV IPKNTEVFPV LSSALHDPRY CC FETPNTFNPG HFLDANGALK RNEGFMPFSL GKRICLGEGI ARTELFLFFT TILQNFSIAS CC PVPPEDIDLT PRESGVGNVP PSYQIRFLAR H CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVY CC ATOM --------GKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVY CC ****************************************** CC SEQRES LGSRPVVVLCGTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGE CC ATOM LGSRPVVVLCGTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGE CC ************************************************** CC SEQRES RWRALRRFSLATMRDFGMGKRSVEERIQEEARCLVEELRKSKGALLDNTL CC ATOM RWRALRRFSLATMRD----KRSVEERIQEEARCLVEELRKSKGALLDNTL CC *************** ******************************* CC SEQRES LFHSITSNIICSIVFGKRFDYKDPVFLRLLDLFFQSFSLISSFSSQVFEL CC ATOM LFHSITSNIICSIVFGKRFDYKDPVFLRLLDLFFQSFSLISSFSSQVFEL CC ************************************************** CC SEQRES FSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPSNPRDFIDVYL CC ATOM FSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPSNPRDFIDVYL CC ************************************************** CC SEQRES LRMEKDKSDPSSEFHHQNLILTVLSLFFAGTETTSTTLRYGFLLMLKYPH CC ATOM LRME----------HHQNLILTVLSLFFAGTETTSTTLRYGFLLMLKYPH CC **** ************************************ CC SEQRES VTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPH CC ATOM VTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPH CC ************************************************** CC SEQRES TVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGA CC ATOM TVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGA CC ************************************************** CC SEQRES LKRNEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDID CC ATOM LKRNEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDID CC ************************************************** CC SEQRES LTPRESGVGNVPPSYQIRFLARHHHH CC ATOM LTPRESGVGNVPPSYQIRFLARH--- CC *********************** SQ SEQUENCE 476 AA; MW; CN; MAKKTSSKGK LPPGPSPLPV LGNLLQMDRK GLLRSFLRLR EKYGDVFTVY LGSRPVVVLC GTDAIREALV DQAEAFSGRG KIAVVDPIFQ GYGVIFANGE RWRALRRFSL ATMRDFGMGK RSVEERIQEE ARCLVEELRK SKGALLDNTL LFHSITSNII CSIVFGKRFD YKDPVFLRLL DLFFQSFSLI SSFSSQVFEL FSGFLKYFPG THRQIYRNLQ EINTFIGQSV EKHRATLDPS NPRDFIDVYL LRMEKDKSDP SSEFHHQNLI LTVLSLFFAG TETTSTTLRY GFLLMLKYPH VTERVQKEIE QVIGSHRPPA LDDRAKMPYT DAVIHEIQRL GDLIPFGVPH TVTKDTQFRG YVIPKNTEVF PVLSSALHDP RYFETPNTFN PGHFLDANGA LKRNEGFMPF SLGKRICLGE GIARTELFLF FTTILQNFSI ASPVPPEDID LTPRESGVGN VPPSYQIRFL ARHHHH // ID 3G5NC STANDARD; PRT; 476 AA. DT CONVERTED FROM PDB (SEQRES) 3G5N DE Cytochrome P450 2B4 OS Oryctolagus cuniculus CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.500 CC R-Factor 0.220 FT #SUB 92 111 TYR C 9 28 GLY A Protein B 1 FT #SUB 92 111 TYR C 355 374 ASP A Protein S 3 FT #SUB 92 111 TYR C 362 381 VAL A Protein S 4 FT #SUB 92 111 TYR C 364 383 PRO A Protein S 4 FT #SUB 96 115 PHE C 357 376 GLN A Protein S 12 FT #SUB 96 115 PHE C 362 381 VAL A Protein S 3 FT #SUB 100 119 GLU C 357 376 GLN A Protein S 2 FT #SUB 355 374 ASP C 92 111 TYR A Protein S 3 FT #SUB 357 376 GLN C 96 115 PHE A Protein S 13 FT #SUB 362 381 VAL C 92 111 TYR A Protein S 1 FT #SUB 362 381 VAL C 96 115 PHE A Protein S 1 FT #SUB 364 383 PRO C 92 111 TYR A Protein S 2 FT #SUB 365 384 LYS C 365 384 LYS A Protein S 4 FT #SUB 88 107 ILE C 88 107 ILE B Protein S 1 FT #SUB 88 107 ILE C 92 111 TYR B Protein S 3 FT #SUB 92 111 TYR C 88 107 ILE B Protein S 4 FT #SUB 11 30 LEU C 88 107 ILE D Protein S 1 FT #SUB 11 30 LEU C 89 108 PHE D Protein S 4 FT #SUB 17 36 PRO C 90 109 GLN D Protein S 1 FT #SUB 18 37 LEU C 265 284 HIS D Protein S 1 FT #SUB 18 37 LEU C 268 287 ASN D Protein S 3 FT #SUB 19 38 PRO C 98 117 ASN D Protein S 1 FT #SUB 19 38 PRO C 101 120 ARG D Protein S 1 FT #SUB 21 40 LEU C 272 291 THR D Protein S 2 FT #SUB 24 43 LEU C 210 229 GLY D Protein S 2 FT #SUB 24 43 LEU C 216 235 TYR D Protein A 4 FT #SUB 25 44 LEU C 219 238 LEU D Protein S 1 FT #SUB 25 44 LEU C 220 239 GLN D Protein B 1 FT #SUB 25 44 LEU C 268 287 ASN D Protein S 3 FT #SUB 25 44 LEU C 271 290 LEU D Protein S 1 FT #SUB 27 46 MET C 216 235 TYR D Protein S 5 FT #SUB 28 47 ASP C 216 235 TYR D Protein B 1 FT #SUB 29 48 ARG C 213 232 ARG D Protein B 6 FT #SUB 30 49 LYS C 213 232 ARG D Protein B 1 FT #SUB 31 50 GLY C 213 232 ARG D Protein B 4 FT #SUB 32 51 LEU C 211 230 THR D Protein S 1 FT #SUB 50 69 TYR C 89 108 PHE D Protein S 4 FT #SUB 50 69 TYR C 90 109 GLN D Protein S 4 FT #SUB 51 70 LEU C 208 227 PHE D Protein A 10 FT #SUB 52 71 GLY C 208 227 PHE D Protein B 2 FT #SUB 53 72 SER C 82 101 ILE D Protein A 4 FT #SUB 53 72 SER C 83 102 ALA D Protein S 2 FT #SUB 53 72 SER C 84 103 VAL D Protein S 2 FT #SUB 53 72 SER C 90 109 GLN D Protein B 1 FT #SUB 54 73 ARG C 81 100 LYS D Protein S 2 FT #SUB 54 73 ARG C 84 103 VAL D Protein S 4 FT #SUB 54 73 ARG C 85 104 VAL D Protein S 1 FT #SUB 54 73 ARG C 86 105 ASP D Protein S 3 FT #SUB 55 74 PRO C 89 108 PHE D Protein S 8 FT #SUB 79 98 ARG C 201 220 PHE D Protein S 12 FT #SUB 79 98 ARG C 202 221 SER D Protein A 3 FT #SUB 80 99 GLY C 202 221 SER D Protein B 3 FT #SUB 80 99 GLY C 203 222 GLY D Protein B 8 FT #SUB 80 99 GLY C 204 223 PHE D Protein B 5 FT #SUB 81 100 LYS C 54 73 ARG D Protein B 2 FT #SUB 81 100 LYS C 203 222 GLY D Protein B 1 FT #SUB 82 101 ILE C 52 71 GLY D Protein B 2 FT #SUB 82 101 ILE C 53 72 SER D Protein B 4 FT #SUB 82 101 ILE C 54 73 ARG D Protein B 3 FT #SUB 82 101 ILE C 200 219 LEU D Protein S 1 FT #SUB 82 101 ILE C 203 222 GLY D Protein A 7 FT #SUB 82 101 ILE C 205 224 LEU D Protein S 2 FT #SUB 83 102 ALA C 53 72 SER D Protein B 4 FT #SUB 83 102 ALA C 200 219 LEU D Protein S 1 FT #SUB 83 102 ALA C 201 220 PHE D Protein S 1 FT #SUB 83 102 ALA C 203 222 GLY D Protein A 3 FT #SUB 84 103 VAL C 53 72 SER D Protein B 4 FT #SUB 84 103 VAL C 54 73 ARG D Protein B 4 FT #SUB 85 104 VAL C 53 72 SER D Protein B 1 FT #SUB 85 104 VAL C 54 73 ARG D Protein B 1 FT #SUB 86 105 ASP C 54 73 ARG D Protein A 4 FT #SUB 88 107 ILE C 11 30 LEU D Protein B 1 FT #SUB 88 107 ILE C 364 383 PRO D Protein S 1 FT #SUB 89 108 PHE C 11 30 LEU D Protein A 4 FT #SUB 89 108 PHE C 50 69 TYR D Protein A 3 FT #SUB 89 108 PHE C 55 74 PRO D Protein S 7 FT #SUB 89 108 PHE C 364 383 PRO D Protein S 4 FT #SUB 89 108 PHE C 367 386 THR D Protein S 2 FT #SUB 90 109 GLN C 17 36 PRO D Protein S 1 FT #SUB 90 109 GLN C 50 69 TYR D Protein S 6 FT #SUB 90 109 GLN C 53 72 SER D Protein S 1 FT #SUB 98 117 ASN C 19 38 PRO D Protein S 2 FT #SUB 101 120 ARG C 19 38 PRO D Protein S 1 FT #SUB 102 121 TRP C 201 220 PHE D Protein S 2 FT #SUB 182 201 LEU C 193 212 PHE D Protein A 2 FT #SUB 183 202 PHE C 192 211 SER D Protein B 2 FT #SUB 183 202 PHE C 193 212 PHE D Protein S 3 FT #SUB 183 202 PHE C 194 213 SER D Protein B 4 FT #SUB 185 204 GLN C 192 211 SER D Protein B 1 FT #SUB 186 205 SER C 190 209 ILE D Protein S 1 FT #SUB 186 205 SER C 191 210 SER D Protein B 2 FT #SUB 187 206 PHE C 190 209 ILE D Protein B 2 FT #SUB 187 206 PHE C 191 210 SER D Protein A 7 FT #SUB 187 206 PHE C 192 211 SER D Protein S 4 FT #SUB 187 206 PHE C 193 212 PHE D Protein S 2 FT #SUB 187 206 PHE C 196 215 GLN D Protein S 6 FT #SUB 188 207 SER C 189 208 LEU D Protein A 3 FT #SUB 189 208 LEU C 188 207 SER D Protein B 3 FT #SUB 189 208 LEU C 189 208 LEU D Protein B 6 FT #SUB 190 209 ILE C 186 205 SER D Protein S 2 FT #SUB 190 209 ILE C 187 206 PHE D Protein B 2 FT #SUB 191 210 SER C 186 205 SER D Protein B 3 FT #SUB 191 210 SER C 187 206 PHE D Protein A 10 FT #SUB 192 211 SER C 183 202 PHE D Protein S 2 FT #SUB 192 211 SER C 185 204 GLN D Protein B 1 FT #SUB 192 211 SER C 187 206 PHE D Protein B 5 FT #SUB 193 212 PHE C 182 201 LEU D Protein S 3 FT #SUB 193 212 PHE C 183 202 PHE D Protein S 1 FT #SUB 193 212 PHE C 187 206 PHE D Protein B 2 FT #SUB 193 212 PHE C 215 234 ILE D Protein S 4 FT #SUB 193 212 PHE C 275 294 SER D Protein S 1 FT #SUB 194 213 SER C 183 202 PHE D Protein A 5 FT #SUB 194 213 SER C 279 298 ALA D Protein B 1 FT #SUB 196 215 GLN C 187 206 PHE D Protein S 6 FT #SUB 196 215 GLN C 209 228 PRO D Protein A 6 FT #SUB 196 215 GLN C 210 229 GLY D Protein S 2 FT #SUB 196 215 GLN C 215 234 ILE D Protein S 1 FT #SUB 197 216 VAL C 275 294 SER D Protein S 3 FT #SUB 198 217 PHE C 276 295 LEU D Protein S 1 FT #SUB 198 217 PHE C 279 298 ALA D Protein S 1 FT #SUB 200 219 LEU C 83 102 ALA D Protein B 1 FT #SUB 200 219 LEU C 208 227 PHE D Protein S 2 FT #SUB 200 219 LEU C 209 228 PRO D Protein S 5 FT #SUB 201 220 PHE C 79 98 ARG D Protein A 13 FT #SUB 201 220 PHE C 83 102 ALA D Protein B 1 FT #SUB 201 220 PHE C 102 121 TRP D Protein S 2 FT #SUB 201 220 PHE C 276 295 LEU D Protein S 5 FT #SUB 202 221 SER C 79 98 ARG D Protein B 3 FT #SUB 202 221 SER C 80 99 GLY D Protein B 2 FT #SUB 202 221 SER C 348 367 VAL D Protein S 1 FT #SUB 203 222 GLY C 80 99 GLY D Protein B 9 FT #SUB 203 222 GLY C 81 100 LYS D Protein B 1 FT #SUB 203 222 GLY C 82 101 ILE D Protein B 7 FT #SUB 203 222 GLY C 83 102 ALA D Protein B 3 FT #SUB 204 223 PHE C 80 99 GLY D Protein S 6 FT #SUB 204 223 PHE C 349 368 PRO D Protein S 9 FT #SUB 204 223 PHE C 350 369 HIS D Protein S 5 FT #SUB 204 223 PHE C 368 387 GLU D Protein S 4 FT #SUB 205 224 LEU C 82 101 ILE D Protein S 2 FT #SUB 205 224 LEU C 207 226 TYR D Protein S 1 FT #SUB 205 224 LEU C 208 227 PHE D Protein S 1 FT #SUB 205 224 LEU C 209 228 PRO D Protein S 1 FT #SUB 206 225 LYS C 458 477 VAL D Protein A 2 FT #SUB 207 226 TYR C 191 210 SER D Protein S 1 FT #SUB 207 226 TYR C 196 215 GLN D Protein S 5 FT #SUB 207 226 TYR C 199 218 GLU D Protein S 5 FT #SUB 207 226 TYR C 205 224 LEU D Protein A 2 FT #SUB 207 226 TYR C 207 226 TYR D Protein S 2 FT #SUB 208 227 PHE C 51 70 LEU D Protein S 10 FT #SUB 208 227 PHE C 52 71 GLY D Protein S 2 FT #SUB 208 227 PHE C 200 219 LEU D Protein S 2 FT #SUB 208 227 PHE C 205 224 LEU D Protein S 1 FT #SUB 209 228 PRO C 24 43 LEU D Protein B 1 FT #SUB 209 228 PRO C 196 215 GLN D Protein A 8 FT #SUB 209 228 PRO C 200 219 LEU D Protein S 4 FT #SUB 209 228 PRO C 205 224 LEU D Protein S 1 FT #SUB 210 229 GLY C 24 43 LEU D Protein B 2 FT #SUB 210 229 GLY C 32 51 LEU D Protein B 1 FT #SUB 210 229 GLY C 196 215 GLN D Protein B 2 FT #SUB 211 230 THR C 32 51 LEU D Protein B 1 FT #SUB 211 230 THR C 457 476 GLY D Protein B 1 FT #SUB 213 232 ARG C 29 48 ARG D Protein S 3 FT #SUB 213 232 ARG C 30 49 LYS D Protein S 1 FT #SUB 213 232 ARG C 31 50 GLY D Protein S 1 FT #SUB 213 232 ARG C 456 475 SER D Protein S 1 FT #SUB 215 234 ILE C 193 212 PHE D Protein S 1 FT #SUB 215 234 ILE C 196 215 GLN D Protein S 1 FT #SUB 216 235 TYR C 24 43 LEU D Protein S 3 FT #SUB 216 235 TYR C 27 46 MET D Protein S 6 FT #SUB 216 235 TYR C 28 47 ASP D Protein S 3 FT #SUB 216 235 TYR C 29 48 ARG D Protein S 2 FT #SUB 219 238 LEU C 25 44 LEU D Protein S 1 FT #SUB 268 287 ASN C 18 37 LEU D Protein S 4 FT #SUB 268 287 ASN C 25 44 LEU D Protein S 3 FT #SUB 271 290 LEU C 25 44 LEU D Protein S 1 FT #SUB 272 291 THR C 21 40 LEU D Protein S 2 FT #SUB 275 294 SER C 193 212 PHE D Protein S 1 FT #SUB 275 294 SER C 197 216 VAL D Protein S 4 FT #SUB 276 295 LEU C 197 216 VAL D Protein S 1 FT #SUB 276 295 LEU C 201 220 PHE D Protein S 2 FT #SUB 279 298 ALA C 194 213 SER D Protein A 4 FT #SUB 279 298 ALA C 198 217 PHE D Protein S 1 FT #SUB 348 367 VAL C 198 217 PHE D Protein S 1 FT #SUB 348 367 VAL C 202 221 SER D Protein S 1 FT #SUB 349 368 PRO C 204 223 PHE D Protein A 12 FT #SUB 350 369 HIS C 204 223 PHE D Protein B 6 FT #SUB 364 383 PRO C 89 108 PHE D Protein S 3 FT #SUB 367 386 THR C 89 108 PHE D Protein S 1 FT #SUB 368 387 GLU C 204 223 PHE D Protein S 8 FT #SUB 457 476 GLY C 211 230 THR D Protein B 1 FT #SUB 458 477 VAL C 206 225 LYS D Protein S 3 FT #HET 20 39 VAL C 16 504 CM5 D S 1 FT #HET 24 43 LEU C 13 502 PB2 C A 7 FT #HET 32 51 LEU C 13 502 PB2 C S 3 FT #HET 50 69 TYR C 13 502 PB2 C B 3 FT #HET 51 70 LEU C 13 502 PB2 C A 8 FT #HET 54 73 ARG C 14 503 PB2 C S 4 FT #HET 77 96 SER C 15 504 CM5 C B 1 FT #HET 79 98 ARG C 11 500 HEM C S 3 FT #HET 79 98 ARG C 15 504 CM5 C S 7 FT #HET 82 101 ILE C 20 503 PB2 D S 1 FT #HET 95 114 ILE C 15 504 CM5 C B 1 FT #HET 98 117 ASN C 15 504 CM5 C A 2 FT #HET 99 118 GLY C 15 504 CM5 C B 2 FT #HET 102 121 TRP C 11 500 HEM C S 3 FT #HET 102 121 TRP C 15 504 CM5 C S 5 FT #HET 106 125 ARG C 11 500 HEM C S 4 FT #HET 198 217 PHE C 17 500 HEM D S 1 FT #HET 198 217 PHE C 18 501 PB2 D S 12 FT #HET 199 218 GLU C 18 501 PB2 D S 2 FT #HET 201 220 PHE C 16 504 CM5 D S 1 FT #HET 201 220 PHE C 17 500 HEM D S 1 FT #HET 204 223 PHE C 18 501 PB2 D B 1 FT #HET 204 223 PHE C 20 503 PB2 D S 2 FT #HET 205 224 LEU C 19 502 PB2 D B 1 FT #HET 205 224 LEU C 20 503 PB2 D B 2 FT #HET 206 225 LYS C 18 501 PB2 D S 2 FT #HET 206 225 LYS C 19 502 PB2 D B 2 FT #HET 208 227 PHE C 19 502 PB2 D S 1 FT #HET 209 228 PRO C 19 502 PB2 D B 4 FT #HET 210 229 GLY C 19 502 PB2 D B 1 FT #HET 211 230 THR C 19 502 PB2 D S 3 FT #HET 269 288 LEU C 15 504 CM5 C S 2 FT #HET 277 296 PHE C 11 500 HEM C A 6 FT #HET 279 298 ALA C 12 501 PB2 C A 6 FT #HET 280 299 GLY C 11 500 HEM C B 16 FT #HET 280 299 GLY C 12 501 PB2 C B 8 FT #HET 281 300 THR C 11 500 HEM C B 1 FT #HET 283 302 THR C 11 500 HEM C S 6 FT #HET 283 302 THR C 12 501 PB2 C S 3 FT #HET 284 303 THR C 11 500 HEM C A 8 FT #HET 287 306 THR C 11 500 HEM C S 1 FT #HET 338 357 GLN C 11 500 HEM C S 1 FT #HET 344 363 ILE C 11 500 HEM C S 4 FT #HET 344 363 ILE C 12 501 PB2 C S 4 FT #HET 346 365 PHE C 13 502 PB2 C S 1 FT #HET 347 366 GLY C 12 501 PB2 C B 2 FT #HET 348 367 VAL C 11 500 HEM C S 2 FT #HET 348 367 VAL C 12 501 PB2 C S 1 FT #HET 349 368 PRO C 12 501 PB2 C S 3 FT #HET 350 369 HIS C 11 500 HEM C S 7 FT #HET 368 387 GLU C 14 503 PB2 C S 6 FT #HET 370 389 PHE C 13 502 PB2 C S 4 FT #HET 373 392 LEU C 11 500 HEM C S 1 FT #HET 409 428 PRO C 11 500 HEM C B 3 FT #HET 410 429 PHE C 11 500 HEM C A 19 FT #HET 411 430 SER C 11 500 HEM C A 8 FT #HET 415 434 ARG C 11 500 HEM C A 20 FT #HET 417 436 CYS C 11 500 HEM C A 24 FT #HET 418 437 LEU C 11 500 HEM C A 10 FT #HET 419 438 GLY C 11 500 HEM C B 12 FT #HET 423 442 ALA C 11 500 HEM C S 1 FT #HET 458 477 VAL C 13 502 PB2 C S 3 FT DISORDER 1 6 FT DISORDER 116 119 FT DISORDER 255 265 FT DISORDER 474 476 CC SEQUENCE 452 AA (ATOM); CC SKGKLPPGPS PLPVLGNLLQ MDRKGLLRSF LRLREKYGDV FTVYLGSRPV VVLCGTDAIR CC EALVDQAEAF SGRGKIAVVD PIFQGYGVIF ANGERWRALR RFSLATMRDK RSVEERIQEE CC ARCLVEELRK SKGALLDNTL LFHSITSNII CSIVFGKRFD YKDPVFLRLL DLFFQSFSLI CC SSFSSQVFEL FSGFLKYFPG THRQIYRNLQ EINTFIGQSV EKHRATLDPS NPRDFIDVYL CC LRMEHQNLIL TVLSLFFAGT ETTSTTLRYG FLLMLKYPHV TERVQKEIEQ VIGSHRPPAL CC DDRAKMPYTD AVIHEIQRLG DLIPFGVPHT VTKDTQFRGY VIPKNTEVFP VLSSALHDPR CC YFETPNTFNP GHFLDANGAL KRNEGFMPFS LGKRICLGEG IARTELFLFF TTILQNFSIA CC SPVPPEDIDL TPRESGVGNV PPSYQIRFLA RH CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVY CC ATOM ------SKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVY CC ******************************************** CC SEQRES LGSRPVVVLCGTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGE CC ATOM LGSRPVVVLCGTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGE CC ************************************************** CC SEQRES RWRALRRFSLATMRDFGMGKRSVEERIQEEARCLVEELRKSKGALLDNTL CC ATOM RWRALRRFSLATMRD----KRSVEERIQEEARCLVEELRKSKGALLDNTL CC *************** ******************************* CC SEQRES LFHSITSNIICSIVFGKRFDYKDPVFLRLLDLFFQSFSLISSFSSQVFEL CC ATOM LFHSITSNIICSIVFGKRFDYKDPVFLRLLDLFFQSFSLISSFSSQVFEL CC ************************************************** CC SEQRES FSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPSNPRDFIDVYL CC ATOM FSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPSNPRDFIDVYL CC ************************************************** CC SEQRES LRMEKDKSDPSSEFHHQNLILTVLSLFFAGTETTSTTLRYGFLLMLKYPH CC ATOM LRME-----------HQNLILTVLSLFFAGTETTSTTLRYGFLLMLKYPH CC **** *********************************** CC SEQRES VTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPH CC ATOM VTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPH CC ************************************************** CC SEQRES TVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGA CC ATOM TVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGA CC ************************************************** CC SEQRES LKRNEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDID CC ATOM LKRNEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDID CC ************************************************** CC SEQRES LTPRESGVGNVPPSYQIRFLARHHHH CC ATOM LTPRESGVGNVPPSYQIRFLARH--- CC *********************** SQ SEQUENCE 476 AA; MW; CN; MAKKTSSKGK LPPGPSPLPV LGNLLQMDRK GLLRSFLRLR EKYGDVFTVY LGSRPVVVLC GTDAIREALV DQAEAFSGRG KIAVVDPIFQ GYGVIFANGE RWRALRRFSL ATMRDFGMGK RSVEERIQEE ARCLVEELRK SKGALLDNTL LFHSITSNII CSIVFGKRFD YKDPVFLRLL DLFFQSFSLI SSFSSQVFEL FSGFLKYFPG THRQIYRNLQ EINTFIGQSV EKHRATLDPS NPRDFIDVYL LRMEKDKSDP SSEFHHQNLI LTVLSLFFAG TETTSTTLRY GFLLMLKYPH VTERVQKEIE QVIGSHRPPA LDDRAKMPYT DAVIHEIQRL GDLIPFGVPH TVTKDTQFRG YVIPKNTEVF PVLSSALHDP RYFETPNTFN PGHFLDANGA LKRNEGFMPF SLGKRICLGE GIARTELFLF FTTILQNFSI ASPVPPEDID LTPRESGVGN VPPSYQIRFL ARHHHH // ID 3G5ND STANDARD; PRT; 476 AA. DT CONVERTED FROM PDB (SEQRES) 3G5N DE Cytochrome P450 2B4 OS Oryctolagus cuniculus CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.500 CC R-Factor 0.220 FT #SUB 88 107 ILE D 88 107 ILE A Protein S 1 FT #SUB 88 107 ILE D 92 111 TYR A Protein S 2 FT #SUB 92 111 TYR D 88 107 ILE A Protein S 2 FT #SUB 92 111 TYR D 355 374 ASP B Protein S 6 FT #SUB 92 111 TYR D 362 381 VAL B Protein S 4 FT #SUB 92 111 TYR D 364 383 PRO B Protein S 5 FT #SUB 96 115 PHE D 355 374 ASP B Protein S 4 FT #SUB 96 115 PHE D 356 375 THR B Protein S 1 FT #SUB 96 115 PHE D 357 376 GLN B Protein S 14 FT #SUB 96 115 PHE D 362 381 VAL B Protein S 1 FT #SUB 100 119 GLU D 357 376 GLN B Protein S 1 FT #SUB 355 374 ASP D 92 111 TYR B Protein S 8 FT #SUB 355 374 ASP D 96 115 PHE B Protein A 4 FT #SUB 356 375 THR D 96 115 PHE B Protein B 1 FT #SUB 357 376 GLN D 96 115 PHE B Protein S 15 FT #SUB 357 376 GLN D 100 119 GLU B Protein S 1 FT #SUB 362 381 VAL D 92 111 TYR B Protein S 4 FT #SUB 362 381 VAL D 96 115 PHE B Protein S 1 FT #SUB 364 383 PRO D 92 111 TYR B Protein S 5 FT #SUB 365 384 LYS D 365 384 LYS B Protein S 3 FT #SUB 11 30 LEU D 88 107 ILE C Protein S 1 FT #SUB 11 30 LEU D 89 108 PHE C Protein S 4 FT #SUB 17 36 PRO D 90 109 GLN C Protein S 1 FT #SUB 18 37 LEU D 268 287 ASN C Protein S 4 FT #SUB 19 38 PRO D 98 117 ASN C Protein S 2 FT #SUB 19 38 PRO D 101 120 ARG C Protein S 1 FT #SUB 21 40 LEU D 272 291 THR C Protein S 2 FT #SUB 24 43 LEU D 209 228 PRO C Protein S 1 FT #SUB 24 43 LEU D 210 229 GLY C Protein S 2 FT #SUB 24 43 LEU D 216 235 TYR C Protein A 3 FT #SUB 25 44 LEU D 219 238 LEU C Protein S 1 FT #SUB 25 44 LEU D 268 287 ASN C Protein S 3 FT #SUB 25 44 LEU D 271 290 LEU C Protein S 1 FT #SUB 27 46 MET D 216 235 TYR C Protein A 6 FT #SUB 28 47 ASP D 216 235 TYR C Protein B 3 FT #SUB 29 48 ARG D 213 232 ARG C Protein B 3 FT #SUB 29 48 ARG D 216 235 TYR C Protein A 2 FT #SUB 30 49 LYS D 213 232 ARG C Protein B 1 FT #SUB 31 50 GLY D 213 232 ARG C Protein B 1 FT #SUB 32 51 LEU D 210 229 GLY C Protein S 1 FT #SUB 32 51 LEU D 211 230 THR C Protein S 1 FT #SUB 50 69 TYR D 89 108 PHE C Protein S 3 FT #SUB 50 69 TYR D 90 109 GLN C Protein S 6 FT #SUB 51 70 LEU D 208 227 PHE C Protein A 10 FT #SUB 52 71 GLY D 82 101 ILE C Protein B 2 FT #SUB 52 71 GLY D 208 227 PHE C Protein B 2 FT #SUB 53 72 SER D 82 101 ILE C Protein A 4 FT #SUB 53 72 SER D 83 102 ALA C Protein S 4 FT #SUB 53 72 SER D 84 103 VAL C Protein A 4 FT #SUB 53 72 SER D 85 104 VAL C Protein S 1 FT #SUB 53 72 SER D 90 109 GLN C Protein B 1 FT #SUB 54 73 ARG D 81 100 LYS C Protein S 2 FT #SUB 54 73 ARG D 82 101 ILE C Protein A 3 FT #SUB 54 73 ARG D 84 103 VAL C Protein S 4 FT #SUB 54 73 ARG D 85 104 VAL C Protein S 1 FT #SUB 54 73 ARG D 86 105 ASP C Protein S 4 FT #SUB 55 74 PRO D 89 108 PHE C Protein S 7 FT #SUB 79 98 ARG D 201 220 PHE C Protein S 13 FT #SUB 79 98 ARG D 202 221 SER C Protein A 3 FT #SUB 80 99 GLY D 202 221 SER C Protein B 2 FT #SUB 80 99 GLY D 203 222 GLY C Protein B 9 FT #SUB 80 99 GLY D 204 223 PHE C Protein B 6 FT #SUB 81 100 LYS D 54 73 ARG C Protein B 2 FT #SUB 81 100 LYS D 203 222 GLY C Protein B 1 FT #SUB 82 101 ILE D 53 72 SER C Protein B 4 FT #SUB 82 101 ILE D 203 222 GLY C Protein A 7 FT #SUB 82 101 ILE D 205 224 LEU C Protein S 2 FT #SUB 83 102 ALA D 53 72 SER C Protein B 2 FT #SUB 83 102 ALA D 200 219 LEU C Protein S 1 FT #SUB 83 102 ALA D 201 220 PHE C Protein S 1 FT #SUB 83 102 ALA D 203 222 GLY C Protein A 3 FT #SUB 84 103 VAL D 53 72 SER C Protein B 2 FT #SUB 84 103 VAL D 54 73 ARG C Protein B 4 FT #SUB 85 104 VAL D 54 73 ARG C Protein B 1 FT #SUB 86 105 ASP D 54 73 ARG C Protein A 3 FT #SUB 88 107 ILE D 11 30 LEU C Protein B 1 FT #SUB 89 108 PHE D 11 30 LEU C Protein A 4 FT #SUB 89 108 PHE D 50 69 TYR C Protein A 4 FT #SUB 89 108 PHE D 55 74 PRO C Protein S 8 FT #SUB 89 108 PHE D 364 383 PRO C Protein S 3 FT #SUB 89 108 PHE D 367 386 THR C Protein S 1 FT #SUB 90 109 GLN D 17 36 PRO C Protein S 1 FT #SUB 90 109 GLN D 50 69 TYR C Protein S 4 FT #SUB 90 109 GLN D 53 72 SER C Protein S 1 FT #SUB 98 117 ASN D 19 38 PRO C Protein S 1 FT #SUB 101 120 ARG D 19 38 PRO C Protein S 1 FT #SUB 102 121 TRP D 201 220 PHE C Protein S 2 FT #SUB 182 201 LEU D 193 212 PHE C Protein A 3 FT #SUB 183 202 PHE D 192 211 SER C Protein B 2 FT #SUB 183 202 PHE D 193 212 PHE C Protein S 1 FT #SUB 183 202 PHE D 194 213 SER C Protein B 5 FT #SUB 185 204 GLN D 192 211 SER C Protein B 1 FT #SUB 186 205 SER D 190 209 ILE C Protein S 2 FT #SUB 186 205 SER D 191 210 SER C Protein A 3 FT #SUB 187 206 PHE D 190 209 ILE C Protein B 2 FT #SUB 187 206 PHE D 191 210 SER C Protein A 10 FT #SUB 187 206 PHE D 192 211 SER C Protein S 5 FT #SUB 187 206 PHE D 193 212 PHE C Protein S 2 FT #SUB 187 206 PHE D 196 215 GLN C Protein S 6 FT #SUB 188 207 SER D 189 208 LEU C Protein A 3 FT #SUB 189 208 LEU D 188 207 SER C Protein B 3 FT #SUB 189 208 LEU D 189 208 LEU C Protein B 6 FT #SUB 190 209 ILE D 186 205 SER C Protein S 1 FT #SUB 190 209 ILE D 187 206 PHE C Protein B 2 FT #SUB 191 210 SER D 186 205 SER C Protein B 2 FT #SUB 191 210 SER D 187 206 PHE C Protein A 7 FT #SUB 191 210 SER D 207 226 TYR C Protein S 1 FT #SUB 192 211 SER D 183 202 PHE C Protein S 2 FT #SUB 192 211 SER D 185 204 GLN C Protein B 1 FT #SUB 192 211 SER D 187 206 PHE C Protein B 4 FT #SUB 193 212 PHE D 182 201 LEU C Protein S 2 FT #SUB 193 212 PHE D 183 202 PHE C Protein S 3 FT #SUB 193 212 PHE D 187 206 PHE C Protein B 2 FT #SUB 193 212 PHE D 215 234 ILE C Protein S 1 FT #SUB 193 212 PHE D 275 294 SER C Protein S 1 FT #SUB 194 213 SER D 183 202 PHE C Protein A 4 FT #SUB 194 213 SER D 279 298 ALA C Protein A 4 FT #SUB 196 215 GLN D 187 206 PHE C Protein S 6 FT #SUB 196 215 GLN D 207 226 TYR C Protein S 5 FT #SUB 196 215 GLN D 209 228 PRO C Protein A 8 FT #SUB 196 215 GLN D 210 229 GLY C Protein S 2 FT #SUB 196 215 GLN D 215 234 ILE C Protein S 1 FT #SUB 197 216 VAL D 275 294 SER C Protein S 4 FT #SUB 197 216 VAL D 276 295 LEU C Protein S 1 FT #SUB 198 217 PHE D 279 298 ALA C Protein S 1 FT #SUB 198 217 PHE D 348 367 VAL C Protein S 1 FT #SUB 199 218 GLU D 207 226 TYR C Protein S 5 FT #SUB 200 219 LEU D 82 101 ILE C Protein S 1 FT #SUB 200 219 LEU D 83 102 ALA C Protein B 1 FT #SUB 200 219 LEU D 208 227 PHE C Protein S 2 FT #SUB 200 219 LEU D 209 228 PRO C Protein S 4 FT #SUB 201 220 PHE D 79 98 ARG C Protein A 12 FT #SUB 201 220 PHE D 83 102 ALA C Protein B 1 FT #SUB 201 220 PHE D 102 121 TRP C Protein S 2 FT #SUB 201 220 PHE D 276 295 LEU C Protein S 2 FT #SUB 202 221 SER D 79 98 ARG C Protein B 3 FT #SUB 202 221 SER D 80 99 GLY C Protein B 3 FT #SUB 202 221 SER D 348 367 VAL C Protein S 1 FT #SUB 203 222 GLY D 80 99 GLY C Protein B 8 FT #SUB 203 222 GLY D 81 100 LYS C Protein B 1 FT #SUB 203 222 GLY D 82 101 ILE C Protein B 7 FT #SUB 203 222 GLY D 83 102 ALA C Protein B 3 FT #SUB 204 223 PHE D 80 99 GLY C Protein S 5 FT #SUB 204 223 PHE D 349 368 PRO C Protein S 12 FT #SUB 204 223 PHE D 350 369 HIS C Protein S 6 FT #SUB 204 223 PHE D 368 387 GLU C Protein S 8 FT #SUB 205 224 LEU D 82 101 ILE C Protein S 2 FT #SUB 205 224 LEU D 207 226 TYR C Protein S 2 FT #SUB 205 224 LEU D 208 227 PHE C Protein S 1 FT #SUB 205 224 LEU D 209 228 PRO C Protein S 1 FT #SUB 206 225 LYS D 458 477 VAL C Protein S 3 FT #SUB 207 226 TYR D 205 224 LEU C Protein B 1 FT #SUB 207 226 TYR D 207 226 TYR C Protein S 2 FT #SUB 208 227 PHE D 51 70 LEU C Protein S 10 FT #SUB 208 227 PHE D 52 71 GLY C Protein S 2 FT #SUB 208 227 PHE D 200 219 LEU C Protein S 2 FT #SUB 208 227 PHE D 205 224 LEU C Protein S 1 FT #SUB 209 228 PRO D 196 215 GLN C Protein A 6 FT #SUB 209 228 PRO D 200 219 LEU C Protein S 5 FT #SUB 209 228 PRO D 205 224 LEU C Protein S 1 FT #SUB 210 229 GLY D 24 43 LEU C Protein B 2 FT #SUB 210 229 GLY D 196 215 GLN C Protein B 2 FT #SUB 211 230 THR D 32 51 LEU C Protein S 1 FT #SUB 211 230 THR D 457 476 GLY C Protein B 1 FT #SUB 213 232 ARG D 29 48 ARG C Protein S 6 FT #SUB 213 232 ARG D 30 49 LYS C Protein S 1 FT #SUB 213 232 ARG D 31 50 GLY C Protein S 4 FT #SUB 215 234 ILE D 193 212 PHE C Protein S 4 FT #SUB 215 234 ILE D 196 215 GLN C Protein S 1 FT #SUB 216 235 TYR D 24 43 LEU C Protein S 4 FT #SUB 216 235 TYR D 27 46 MET C Protein S 5 FT #SUB 216 235 TYR D 28 47 ASP C Protein S 1 FT #SUB 219 238 LEU D 25 44 LEU C Protein S 1 FT #SUB 220 239 GLN D 25 44 LEU C Protein S 1 FT #SUB 265 284 HIS D 18 37 LEU C Protein B 1 FT #SUB 268 287 ASN D 18 37 LEU C Protein S 3 FT #SUB 268 287 ASN D 25 44 LEU C Protein S 3 FT #SUB 271 290 LEU D 25 44 LEU C Protein S 1 FT #SUB 272 291 THR D 21 40 LEU C Protein S 2 FT #SUB 275 294 SER D 193 212 PHE C Protein S 1 FT #SUB 275 294 SER D 197 216 VAL C Protein S 3 FT #SUB 276 295 LEU D 198 217 PHE C Protein S 1 FT #SUB 276 295 LEU D 201 220 PHE C Protein S 5 FT #SUB 279 298 ALA D 194 213 SER C Protein S 1 FT #SUB 279 298 ALA D 198 217 PHE C Protein S 1 FT #SUB 348 367 VAL D 202 221 SER C Protein S 1 FT #SUB 349 368 PRO D 204 223 PHE C Protein A 9 FT #SUB 350 369 HIS D 204 223 PHE C Protein B 5 FT #SUB 364 383 PRO D 88 107 ILE C Protein S 1 FT #SUB 364 383 PRO D 89 108 PHE C Protein S 4 FT #SUB 367 386 THR D 89 108 PHE C Protein S 2 FT #SUB 368 387 GLU D 204 223 PHE C Protein S 4 FT #SUB 456 475 SER D 213 232 ARG C Protein B 1 FT #SUB 457 476 GLY D 211 230 THR C Protein B 1 FT #SUB 458 477 VAL D 206 225 LYS C Protein S 2 FT #HET 20 39 VAL D 15 504 CM5 C S 1 FT #HET 23 42 ASN D 19 502 PB2 D B 1 FT #HET 24 43 LEU D 19 502 PB2 D A 7 FT #HET 50 69 TYR D 19 502 PB2 D B 2 FT #HET 51 70 LEU D 19 502 PB2 D A 4 FT #HET 51 70 LEU D 20 503 PB2 D S 2 FT #HET 54 73 ARG D 20 503 PB2 D S 5 FT #HET 79 98 ARG D 16 504 CM5 D S 8 FT #HET 79 98 ARG D 17 500 HEM D S 4 FT #HET 98 117 ASN D 16 504 CM5 D A 5 FT #HET 102 121 TRP D 16 504 CM5 D S 4 FT #HET 102 121 TRP D 17 500 HEM D S 5 FT #HET 106 125 ARG D 17 500 HEM D S 4 FT #HET 195 214 SER D 12 501 PB2 C S 1 FT #HET 198 217 PHE D 11 500 HEM C S 4 FT #HET 198 217 PHE D 12 501 PB2 C S 14 FT #HET 199 218 GLU D 12 501 PB2 C S 2 FT #HET 201 220 PHE D 11 500 HEM C S 2 FT #HET 201 220 PHE D 15 504 CM5 C S 1 FT #HET 202 221 SER D 12 501 PB2 C S 1 FT #HET 204 223 PHE D 12 501 PB2 C B 2 FT #HET 204 223 PHE D 14 503 PB2 C A 6 FT #HET 205 224 LEU D 13 502 PB2 C B 1 FT #HET 205 224 LEU D 14 503 PB2 C A 10 FT #HET 206 225 LYS D 13 502 PB2 C B 2 FT #HET 208 227 PHE D 13 502 PB2 C S 2 FT #HET 209 228 PRO D 13 502 PB2 C B 3 FT #HET 210 229 GLY D 13 502 PB2 C B 1 FT #HET 211 230 THR D 13 502 PB2 C S 3 FT #HET 269 288 LEU D 16 504 CM5 D S 2 FT #HET 272 291 THR D 16 504 CM5 D S 1 FT #HET 277 296 PHE D 17 500 HEM D A 6 FT #HET 279 298 ALA D 18 501 PB2 D B 5 FT #HET 280 299 GLY D 17 500 HEM D B 15 FT #HET 280 299 GLY D 18 501 PB2 D B 8 FT #HET 281 300 THR D 17 500 HEM D B 1 FT #HET 283 302 THR D 17 500 HEM D A 7 FT #HET 283 302 THR D 18 501 PB2 D S 3 FT #HET 284 303 THR D 17 500 HEM D A 6 FT #HET 287 306 THR D 17 500 HEM D S 1 FT #HET 344 363 ILE D 17 500 HEM D S 5 FT #HET 344 363 ILE D 18 501 PB2 D S 1 FT #HET 346 365 PHE D 19 502 PB2 D S 2 FT #HET 347 366 GLY D 18 501 PB2 D B 1 FT #HET 348 367 VAL D 17 500 HEM D S 2 FT #HET 348 367 VAL D 18 501 PB2 D S 1 FT #HET 349 368 PRO D 18 501 PB2 D S 2 FT #HET 349 368 PRO D 19 502 PB2 D S 1 FT #HET 350 369 HIS D 17 500 HEM D S 7 FT #HET 368 387 GLU D 20 503 PB2 D S 9 FT #HET 370 389 PHE D 19 502 PB2 D S 5 FT #HET 370 389 PHE D 20 503 PB2 D S 2 FT #HET 373 392 LEU D 17 500 HEM D S 1 FT #HET 409 428 PRO D 17 500 HEM D B 4 FT #HET 410 429 PHE D 17 500 HEM D A 18 FT #HET 411 430 SER D 17 500 HEM D S 7 FT #HET 415 434 ARG D 16 504 CM5 D S 1 FT #HET 415 434 ARG D 17 500 HEM D A 15 FT #HET 417 436 CYS D 17 500 HEM D A 25 FT #HET 418 437 LEU D 17 500 HEM D A 8 FT #HET 419 438 GLY D 17 500 HEM D B 6 FT #HET 423 442 ALA D 17 500 HEM D S 3 FT #HET 458 477 VAL D 19 502 PB2 D S 6 FT DISORDER 1 8 FT DISORDER 117 120 FT DISORDER 255 264 FT DISORDER 474 476 CC SEQUENCE 451 AA (ATOM); CC GKLPPGPSPL PVLGNLLQMD RKGLLRSFLR LREKYGDVFT VYLGSRPVVV LCGTDAIREA CC LVDQAEAFSG RGKIAVVDPI FQGYGVIFAN GERWRALRRF SLATMRDFRS VEERIQEEAR CC CLVEELRKSK GALLDNTLLF HSITSNIICS IVFGKRFDYK DPVFLRLLDL FFQSFSLISS CC FSSQVFELFS GFLKYFPGTH RQIYRNLQEI NTFIGQSVEK HRATLDPSNP RDFIDVYLLR CC MEHHQNLILT VLSLFFAGTE TTSTTLRYGF LLMLKYPHVT ERVQKEIEQV IGSHRPPALD CC DRAKMPYTDA VIHEIQRLGD LIPFGVPHTV TKDTQFRGYV IPKNTEVFPV LSSALHDPRY CC FETPNTFNPG HFLDANGALK RNEGFMPFSL GKRICLGEGI ARTELFLFFT TILQNFSIAS CC PVPPEDIDLT PRESGVGNVP PSYQIRFLAR H CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVY CC ATOM --------GKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVY CC ****************************************** CC SEQRES LGSRPVVVLCGTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGE CC ATOM LGSRPVVVLCGTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGE CC ************************************************** CC SEQRES RWRALRRFSLATMRDFGMGKRSVEERIQEEARCLVEELRKSKGALLDNTL CC ATOM RWRALRRFSLATMRDF----RSVEERIQEEARCLVEELRKSKGALLDNTL CC **************** ****************************** CC SEQRES LFHSITSNIICSIVFGKRFDYKDPVFLRLLDLFFQSFSLISSFSSQVFEL CC ATOM LFHSITSNIICSIVFGKRFDYKDPVFLRLLDLFFQSFSLISSFSSQVFEL CC ************************************************** CC SEQRES FSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPSNPRDFIDVYL CC ATOM FSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPSNPRDFIDVYL CC ************************************************** CC SEQRES LRMEKDKSDPSSEFHHQNLILTVLSLFFAGTETTSTTLRYGFLLMLKYPH CC ATOM LRME----------HHQNLILTVLSLFFAGTETTSTTLRYGFLLMLKYPH CC **** ************************************ CC SEQRES VTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPH CC ATOM VTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPH CC ************************************************** CC SEQRES TVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGA CC ATOM TVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGA CC ************************************************** CC SEQRES LKRNEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDID CC ATOM LKRNEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDID CC ************************************************** CC SEQRES LTPRESGVGNVPPSYQIRFLARHHHH CC ATOM LTPRESGVGNVPPSYQIRFLARH--- CC *********************** SQ SEQUENCE 476 AA; MW; CN; MAKKTSSKGK LPPGPSPLPV LGNLLQMDRK GLLRSFLRLR EKYGDVFTVY LGSRPVVVLC GTDAIREALV DQAEAFSGRG KIAVVDPIFQ GYGVIFANGE RWRALRRFSL ATMRDFGMGK RSVEERIQEE ARCLVEELRK SKGALLDNTL LFHSITSNII CSIVFGKRFD YKDPVFLRLL DLFFQSFSLI SSFSSQVFEL FSGFLKYFPG THRQIYRNLQ EINTFIGQSV EKHRATLDPS NPRDFIDVYL LRMEKDKSDP SSEFHHQNLI LTVLSLFFAG TETTSTTLRY GFLLMLKYPH VTERVQKEIE QVIGSHRPPA LDDRAKMPYT DAVIHEIQRL GDLIPFGVPH TVTKDTQFRG YVIPKNTEVF PVLSSALHDP RYFETPNTFN PGHFLDANGA LKRNEGFMPF SLGKRICLGE GIARTELFLF FTTILQNFSI ASPVPPEDID LTPRESGVGN VPPSYQIRFL ARHHHH //