ID	3G45A	STANDARD;	PRT;	421	AA.
DT	CONVERTED FROM PDB (SEQRES) 3G45
DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4B
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.630
CC	R-Factor	0.181
FT	#SUB	89	 333 	GLU	A	414	 658 	GLN	B	Protein	B	1
FT	#SUB	90	 334 	ASN	A	413	 657 	PRO	B	Protein	S	5
FT	#SUB	116	 360 	HIS	A	362	 606 	LYS	B	Protein	B	2
FT	#SUB	116	 360 	HIS	A	363	 607 	HIS	B	Protein	A	8
FT	#SUB	116	 360 	HIS	A	365	 609 	ALA	B	Protein	S	2
FT	#SUB	117	 361 	ASN	A	343	 587 	PHE	B	Protein	S	1
FT	#SUB	117	 361 	ASN	A	362	 606 	LYS	B	Protein	S	5
FT	#SUB	117	 361 	ASN	A	363	 607 	HIS	B	Protein	B	2
FT	#SUB	118	 362 	ARG	A	363	 607 	HIS	B	Protein	S	14
FT	#SUB	157	 401 	SER	A	340	 584 	GLU	B	Protein	B	3
FT	#SUB	157	 401 	SER	A	347	 591 	ASP	B	Protein	S	2
FT	#SUB	157	 401 	SER	A	362	 606 	LYS	B	Protein	S	3
FT	#SUB	158	 402 	ASP	A	344	 588 	GLN	B	Protein	A	4
FT	#SUB	343	 587 	PHE	A	117	 361 	ASN	B	Protein	S	1
FT	#SUB	344	 588 	GLN	A	157	 401 	SER	B	Protein	S	1
FT	#SUB	344	 588 	GLN	A	158	 402 	ASP	B	Protein	S	5
FT	#SUB	347	 591 	ASP	A	157	 401 	SER	B	Protein	S	2
FT	#SUB	362	 606 	LYS	A	116	 360 	HIS	B	Protein	B	2
FT	#SUB	362	 606 	LYS	A	117	 361 	ASN	B	Protein	A	5
FT	#SUB	362	 606 	LYS	A	157	 401 	SER	B	Protein	S	4
FT	#SUB	363	 607 	HIS	A	116	 360 	HIS	B	Protein	A	7
FT	#SUB	363	 607 	HIS	A	117	 361 	ASN	B	Protein	S	2
FT	#SUB	363	 607 	HIS	A	118	 362 	ARG	B	Protein	S	13
FT	#SUB	365	 609 	ALA	A	116	 360 	HIS	B	Protein	B	2
FT	#SUB	413	 657 	PRO	A	90	 334 	ASN	B	Protein	S	2
FT	#HET	32	 271 	VAL	A	3	901 	988	A	S	1
FT	#HET	35	 274 	TYR	A	3	901 	988	A	S	10
FT	#HET	39	 278 	THR	A	3	901 	988	A	S	2
FT	#HET	162	 406 	HIS	A	3	901 	988	A	S	3
FT	#HET	166	 410 	HIS	A	1	801 	ZN	A	S	3
FT	#HET	202	 446 	HIS	A	1	801 	ZN	A	S	3
FT	#HET	203	 447 	ASP	A	1	801 	ZN	A	S	3
FT	#HET	203	 447 	ASP	A	2	802 	MG	A	S	3
FT	#HET	275	 519 	MET	A	3	901 	988	A	S	2
FT	#HET	320	 564 	ASP	A	1	801 	ZN	A	S	3
FT	#HET	321	 565 	LEU	A	3	901 	988	A	S	1
FT	#HET	323	 567 	ASN	A	3	901 	988	A	S	4
FT	#HET	335	 579 	THR	A	3	901 	988	A	A	2
FT	#HET	338	 582 	ILE	A	3	901 	988	A	S	4
FT	#HET	339	 583 	MET	A	3	901 	988	A	S	1
FT	#HET	342	 586 	PHE	A	3	901 	988	A	S	1
FT	#HET	359	 603 	MET	A	3	901 	988	A	S	2
FT	#HET	370	 614 	SER	A	3	901 	988	A	A	2
FT	#HET	371	 615 	GLN	A	3	901 	988	A	S	9
FT	#HET	374	 618 	PHE	A	3	901 	988	A	A	26
FT	DISORDER	1	7
FT	DISORDER	43	78
FT	DISORDER	415	421
CC	SEQUENCE	371 AA (ATOM);
CC	SNKFKRMLNR ELTHLSEMSR SGNQVSEYIS NTFLDTSISR FGVNTENEDH LAKELEDLNK
CC	WGLNIFNVAG YSHNRPLTCI MYAIFQERDL LKTFRISSDT FITYMMTLED HYHSDVAYHN
CC	SLHAADVAQS THVLLSTPAL DAVFTDLEIL AAIFAAAIHD VDHPGVSNQF LINTNSELAL
CC	MYNDESVLEN HHLAVGFKLL QEEHCDIFMN LTKKQRQTLR KMVIDMVLAT DMSKHMSLLA
CC	DLKTMVETKK VTSSGVLLLD NYTDRIQVLR NMVHCADLSN PTKSLELYRQ WTDRIMEEFF
CC	QQGDKERERG MEISPMCDKH TASVEKSQVG FIDYIVHPLW ETWADLVQPD AQDILDTLED
CC	NRNWYQSMIP Q
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIP
CC	ATOM   -------SNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLD--------
CC	              ***********************************        
CC	SEQRES KVTAEEAPQPMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELED
CC	ATOM   ----------------------------TSISRFGVNTENEDHLAKELED
CC	                                   **********************
CC	SEQRES LNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMT
CC	ATOM   LNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMT
CC	       **************************************************
CC	SEQRES LEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAA
CC	ATOM   LEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAA
CC	       **************************************************
CC	SEQRES IHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDI
CC	ATOM   IHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDI
CC	       **************************************************
CC	SEQRES FMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVL
CC	ATOM   FMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVL
CC	       **************************************************
CC	SEQRES LLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKER
CC	ATOM   LLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKER
CC	       **************************************************
CC	SEQRES ERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDT
CC	ATOM   ERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDT
CC	       **************************************************
CC	SEQRES LEDNRNWYQSMIPQSHHHHHH
CC	ATOM   LEDNRNWYQSMIPQ-------
CC	       **************       
SQ	SEQUENCE	421 AA;      MW;         CN;
	MSVSEMASNK FKRMLNRELT HLSEMSRSGN QVSEYISNTF LDKQNDVEIP KVTAEEAPQP
	MTQISGVKKL MHSSSLNNTS ISRFGVNTEN EDHLAKELED LNKWGLNIFN VAGYSHNRPL
	TCIMYAIFQE RDLLKTFRIS SDTFITYMMT LEDHYHSDVA YHNSLHAADV AQSTHVLLST
	PALDAVFTDL EILAAIFAAA IHDVDHPGVS NQFLINTNSE LALMYNDESV LENHHLAVGF
	KLLQEEHCDI FMNLTKKQRQ TLRKMVIDMV LATDMSKHMS LLADLKTMVE TKKVTSSGVL
	LLDNYTDRIQ VLRNMVHCAD LSNPTKSLEL YRQWTDRIME EFFQQGDKER ERGMEISPMC
	DKHTASVEKS QVGFIDYIVH PLWETWADLV QPDAQDILDT LEDNRNWYQS MIPQSHHHHH
	H
//
ID	3G45B	STANDARD;	PRT;	421	AA.
DT	CONVERTED FROM PDB (SEQRES) 3G45
DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4B
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.630
CC	R-Factor	0.181
FT	#SUB	90	 334 	ASN	B	413	 657 	PRO	A	Protein	S	2
FT	#SUB	116	 360 	HIS	B	362	 606 	LYS	A	Protein	B	2
FT	#SUB	116	 360 	HIS	B	363	 607 	HIS	A	Protein	A	7
FT	#SUB	116	 360 	HIS	B	365	 609 	ALA	A	Protein	S	2
FT	#SUB	117	 361 	ASN	B	343	 587 	PHE	A	Protein	S	1
FT	#SUB	117	 361 	ASN	B	362	 606 	LYS	A	Protein	S	5
FT	#SUB	117	 361 	ASN	B	363	 607 	HIS	A	Protein	B	2
FT	#SUB	118	 362 	ARG	B	363	 607 	HIS	A	Protein	S	13
FT	#SUB	157	 401 	SER	B	344	 588 	GLN	A	Protein	B	1
FT	#SUB	157	 401 	SER	B	347	 591 	ASP	A	Protein	S	2
FT	#SUB	157	 401 	SER	B	362	 606 	LYS	A	Protein	S	4
FT	#SUB	158	 402 	ASP	B	344	 588 	GLN	A	Protein	A	5
FT	#SUB	340	 584 	GLU	B	157	 401 	SER	A	Protein	S	3
FT	#SUB	343	 587 	PHE	B	117	 361 	ASN	A	Protein	S	1
FT	#SUB	344	 588 	GLN	B	158	 402 	ASP	A	Protein	S	4
FT	#SUB	347	 591 	ASP	B	157	 401 	SER	A	Protein	S	2
FT	#SUB	362	 606 	LYS	B	116	 360 	HIS	A	Protein	B	2
FT	#SUB	362	 606 	LYS	B	117	 361 	ASN	A	Protein	A	5
FT	#SUB	362	 606 	LYS	B	157	 401 	SER	A	Protein	S	3
FT	#SUB	363	 607 	HIS	B	116	 360 	HIS	A	Protein	A	8
FT	#SUB	363	 607 	HIS	B	117	 361 	ASN	A	Protein	S	2
FT	#SUB	363	 607 	HIS	B	118	 362 	ARG	A	Protein	S	14
FT	#SUB	365	 609 	ALA	B	116	 360 	HIS	A	Protein	B	2
FT	#SUB	413	 657 	PRO	B	90	 334 	ASN	A	Protein	S	5
FT	#SUB	414	 658 	GLN	B	89	 333 	GLU	A	Protein	S	1
FT	#HET	32	 271 	VAL	B	6	901 	988	B	S	1
FT	#HET	35	 274 	TYR	B	6	901 	988	B	S	9
FT	#HET	39	 278 	THR	B	6	901 	988	B	S	2
FT	#HET	162	 406 	HIS	B	6	901 	988	B	S	2
FT	#HET	166	 410 	HIS	B	4	801 	ZN	B	S	3
FT	#HET	202	 446 	HIS	B	4	801 	ZN	B	S	3
FT	#HET	203	 447 	ASP	B	4	801 	ZN	B	S	3
FT	#HET	203	 447 	ASP	B	5	802 	MG	B	S	3
FT	#HET	275	 519 	MET	B	6	901 	988	B	S	6
FT	#HET	320	 564 	ASP	B	4	801 	ZN	B	S	3
FT	#HET	321	 565 	LEU	B	6	901 	988	B	S	1
FT	#HET	323	 567 	ASN	B	6	901 	988	B	S	2
FT	#HET	335	 579 	THR	B	6	901 	988	B	A	2
FT	#HET	338	 582 	ILE	B	6	901 	988	B	S	6
FT	#HET	339	 583 	MET	B	6	901 	988	B	S	1
FT	#HET	342	 586 	PHE	B	6	901 	988	B	S	2
FT	#HET	370	 614 	SER	B	6	901 	988	B	A	6
FT	#HET	371	 615 	GLN	B	6	901 	988	B	S	9
FT	#HET	374	 618 	PHE	B	6	901 	988	B	A	25
FT	DISORDER	1	7
FT	DISORDER	43	79
FT	DISORDER	415	421
CC	SEQUENCE	370 AA (ATOM);
CC	SNKFKRMLNR ELTHLSEMSR SGNQVSEYIS NTFLDSISRF GVNTENEDHL AKELEDLNKW
CC	GLNIFNVAGY SHNRPLTCIM YAIFQERDLL KTFRISSDTF ITYMMTLEDH YHSDVAYHNS
CC	LHAADVAQST HVLLSTPALD AVFTDLEILA AIFAAAIHDV DHPGVSNQFL INTNSELALM
CC	YNDESVLENH HLAVGFKLLQ EEHCDIFMNL TKKQRQTLRK MVIDMVLATD MSKHMSLLAD
CC	LKTMVETKKV TSSGVLLLDN YTDRIQVLRN MVHCADLSNP TKSLELYRQW TDRIMEEFFQ
CC	QGDKERERGM EISPMCDKHT ASVEKSQVGF IDYIVHPLWE TWADLVQPDA QDILDTLEDN
CC	RNWYQSMIPQ
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIP
CC	ATOM   -------SNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLD--------
CC	              ***********************************        
CC	SEQRES KVTAEEAPQPMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELED
CC	ATOM   -----------------------------SISRFGVNTENEDHLAKELED
CC	                                    *********************
CC	SEQRES LNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMT
CC	ATOM   LNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMT
CC	       **************************************************
CC	SEQRES LEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAA
CC	ATOM   LEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAA
CC	       **************************************************
CC	SEQRES IHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDI
CC	ATOM   IHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDI
CC	       **************************************************
CC	SEQRES FMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVL
CC	ATOM   FMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVL
CC	       **************************************************
CC	SEQRES LLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKER
CC	ATOM   LLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKER
CC	       **************************************************
CC	SEQRES ERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDT
CC	ATOM   ERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDT
CC	       **************************************************
CC	SEQRES LEDNRNWYQSMIPQSHHHHHH
CC	ATOM   LEDNRNWYQSMIPQ-------
CC	       **************       
SQ	SEQUENCE	421 AA;      MW;         CN;
	MSVSEMASNK FKRMLNRELT HLSEMSRSGN QVSEYISNTF LDKQNDVEIP KVTAEEAPQP
	MTQISGVKKL MHSSSLNNTS ISRFGVNTEN EDHLAKELED LNKWGLNIFN VAGYSHNRPL
	TCIMYAIFQE RDLLKTFRIS SDTFITYMMT LEDHYHSDVA YHNSLHAADV AQSTHVLLST
	PALDAVFTDL EILAAIFAAA IHDVDHPGVS NQFLINTNSE LALMYNDESV LENHHLAVGF
	KLLQEEHCDI FMNLTKKQRQ TLRKMVIDMV LATDMSKHMS LLADLKTMVE TKKVTSSGVL
	LLDNYTDRIQ VLRNMVHCAD LSNPTKSLEL YRQWTDRIME EFFQQGDKER ERGMEISPMC
	DKHTASVEKS QVGFIDYIVH PLWETWADLV QPDAQDILDT LEDNRNWYQS MIPQSHHHHH
	H
//