ID 2R4FA STANDARD; PRT; 441 AA. DT CONVERTED FROM PDB (SEQRES) 2R4F DE 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.700 CC R-Factor 0.215 FT #SUB 65 499 LEU A 106 540 VAL B Protein S 1 FT #SUB 65 499 LEU A 118 552 GLN B Protein S 3 FT #SUB 65 499 LEU A 386 820 MET B Protein S 1 FT #SUB 68 502 LYS A 118 552 GLN B Protein S 1 FT #SUB 69 503 LEU A 386 820 MET B Protein S 2 FT #SUB 74 508 SER A 382 816 ALA B Protein B 4 FT #SUB 74 508 SER A 385 819 GLN B Protein A 5 FT #SUB 74 508 SER A 386 820 MET B Protein S 1 FT #SUB 75 509 LEU A 386 820 MET B Protein S 2 FT #SUB 77 511 TYR A 378 812 LEU B Protein S 3 FT #SUB 77 511 TYR A 379 813 PRO B Protein B 4 FT #SUB 78 512 LEU A 382 816 ALA B Protein A 2 FT #SUB 83 517 TYR A 101 535 PRO B Protein S 2 FT #SUB 83 517 TYR A 103 537 PRO B Protein S 1 FT #SUB 88 522 VAL A 103 537 PRO B Protein S 3 FT #SUB 91 525 ALA A 126 560 GLY B Protein B 3 FT #SUB 92 526 CYS A 123 557 THR B Protein B 1 FT #SUB 92 526 CYS A 124 558 THR B Protein A 12 FT #SUB 92 526 CYS A 125 559 GLU B Protein B 5 FT #SUB 92 526 CYS A 126 560 GLY B Protein B 5 FT #SUB 93 527 CYS A 103 537 PRO B Protein S 1 FT #SUB 93 527 CYS A 105 539 GLY B Protein S 2 FT #SUB 93 527 CYS A 129 563 VAL B Protein S 1 FT #SUB 94 528 GLU A 105 539 GLY B Protein B 1 FT #SUB 94 528 GLU A 126 560 GLY B Protein S 2 FT #SUB 94 528 GLU A 127 561 CYS B Protein S 8 FT #SUB 94 528 GLU A 128 562 LEU B Protein S 1 FT #SUB 94 528 GLU A 129 563 VAL B Protein A 6 FT #SUB 94 528 GLU A 130 564 ALA B Protein S 6 FT #SUB 95 529 ASN A 105 539 GLY B Protein B 3 FT #SUB 95 529 ASN A 106 540 VAL B Protein A 7 FT #SUB 95 529 ASN A 129 563 VAL B Protein S 1 FT #SUB 96 530 VAL A 104 538 VAL B Protein A 4 FT #SUB 97 531 ILE A 104 538 VAL B Protein A 5 FT #SUB 97 531 ILE A 106 540 VAL B Protein S 1 FT #SUB 97 531 ILE A 386 820 MET B Protein S 2 FT #SUB 98 532 GLY A 103 537 PRO B Protein B 2 FT #SUB 98 532 GLY A 104 538 VAL B Protein B 6 FT #SUB 99 533 TYR A 99 533 TYR B Protein S 2 FT #SUB 99 533 TYR A 101 535 PRO B Protein S 2 FT #SUB 99 533 TYR A 102 536 ILE B Protein A 3 FT #SUB 99 533 TYR A 104 538 VAL B Protein B 2 FT #SUB 100 534 MET A 100 534 MET B Protein B 2 FT #SUB 100 534 MET A 101 535 PRO B Protein B 2 FT #SUB 100 534 MET A 102 536 ILE B Protein A 11 FT #SUB 100 534 MET A 104 538 VAL B Protein A 2 FT #SUB 100 534 MET A 328 762 ILE B Protein S 1 FT #SUB 100 534 MET A 329 763 ALA B Protein S 1 FT #SUB 100 534 MET A 379 813 PRO B Protein S 4 FT #SUB 100 534 MET A 380 814 GLN B Protein S 9 FT #SUB 100 534 MET A 383 817 CYS B Protein S 1 FT #SUB 101 535 PRO A 83 517 TYR B Protein S 1 FT #SUB 101 535 PRO A 99 533 TYR B Protein S 2 FT #SUB 101 535 PRO A 100 534 MET B Protein B 2 FT #SUB 101 535 PRO A 379 813 PRO B Protein S 1 FT #SUB 101 535 PRO A 380 814 GLN B Protein B 1 FT #SUB 102 536 ILE A 99 533 TYR B Protein B 3 FT #SUB 102 536 ILE A 100 534 MET B Protein A 11 FT #SUB 102 536 ILE A 102 536 ILE B Protein S 1 FT #SUB 102 536 ILE A 328 762 ILE B Protein S 1 FT #SUB 102 536 ILE A 380 814 GLN B Protein S 1 FT #SUB 103 537 PRO A 83 517 TYR B Protein S 1 FT #SUB 103 537 PRO A 88 522 VAL B Protein S 3 FT #SUB 103 537 PRO A 93 527 CYS B Protein S 1 FT #SUB 103 537 PRO A 98 532 GLY B Protein B 2 FT #SUB 104 538 VAL A 96 530 VAL B Protein B 4 FT #SUB 104 538 VAL A 97 531 ILE B Protein A 4 FT #SUB 104 538 VAL A 98 532 GLY B Protein A 6 FT #SUB 104 538 VAL A 99 533 TYR B Protein S 1 FT #SUB 104 538 VAL A 100 534 MET B Protein S 2 FT #SUB 105 539 GLY A 93 527 CYS B Protein B 2 FT #SUB 105 539 GLY A 94 528 GLU B Protein B 1 FT #SUB 105 539 GLY A 95 529 ASN B Protein B 3 FT #SUB 106 540 VAL A 65 499 LEU B Protein S 1 FT #SUB 106 540 VAL A 95 529 ASN B Protein A 8 FT #SUB 106 540 VAL A 97 531 ILE B Protein S 1 FT #SUB 118 552 GLN A 65 499 LEU B Protein S 4 FT #SUB 118 552 GLN A 68 502 LYS B Protein S 1 FT #SUB 123 557 THR A 92 526 CYS B Protein B 1 FT #SUB 123 557 THR A 93 527 CYS B Protein B 1 FT #SUB 124 558 THR A 92 526 CYS B Protein B 12 FT #SUB 124 558 THR A 374 808 GLY B Protein S 3 FT #SUB 124 558 THR A 377 811 LEU B Protein S 1 FT #SUB 125 559 GLU A 92 526 CYS B Protein B 5 FT #SUB 125 559 GLU A 257 691 LYS B Protein S 3 FT #SUB 125 559 GLU A 333 767 ASP B Protein S 2 FT #SUB 126 560 GLY A 91 525 ALA B Protein B 3 FT #SUB 126 560 GLY A 92 526 CYS B Protein B 5 FT #SUB 126 560 GLY A 94 528 GLU B Protein B 2 FT #SUB 127 561 CYS A 94 528 GLU B Protein B 8 FT #SUB 128 562 LEU A 94 528 GLU B Protein B 1 FT #SUB 129 563 VAL A 93 527 CYS B Protein S 1 FT #SUB 129 563 VAL A 94 528 GLU B Protein A 7 FT #SUB 130 564 ALA A 94 528 GLU B Protein A 6 FT #SUB 133 567 ASN A 95 529 ASN B Protein S 2 FT #SUB 161 595 ARG A 296 730 GLU B Protein S 8 FT #SUB 161 595 ARG A 300 734 ASN B Protein S 1 FT #SUB 204 638 ILE A 308 742 MET B Protein B 1 FT #SUB 205 639 ALA A 304 738 VAL B Protein S 1 FT #SUB 208 642 ASN A 300 734 ASN B Protein S 4 FT #SUB 210 644 TYR A 300 734 ASN B Protein S 5 FT #SUB 210 644 TYR A 304 738 VAL B Protein S 4 FT #SUB 210 644 TYR A 305 739 GLY B Protein S 4 FT #SUB 210 644 TYR A 308 742 MET B Protein S 1 FT #SUB 247 681 LEU A 296 730 GLU B Protein S 1 FT #SUB 247 681 LEU A 297 731 VAL B Protein A 2 FT #SUB 247 681 LEU A 300 734 ASN B Protein S 3 FT #SUB 247 681 LEU A 423 857 LEU B Protein B 1 FT #SUB 249 683 VAL A 423 857 LEU B Protein S 1 FT #SUB 250 684 SER A 301 735 LYS B Protein A 7 FT #SUB 251 685 GLY A 301 735 LYS B Protein B 4 FT #SUB 251 685 GLY A 305 739 GLY B Protein B 2 FT #SUB 252 686 ASN A 301 735 LYS B Protein A 13 FT #SUB 252 686 ASN A 302 736 ASN B Protein S 2 FT #SUB 252 686 ASN A 305 739 GLY B Protein B 1 FT #SUB 252 686 ASN A 306 740 SER B Protein S 4 FT #SUB 252 686 ASN A 309 743 ALA B Protein B 1 FT #SUB 252 686 ASN A 316 750 ASN B Protein S 4 FT #SUB 253 687 TYR A 308 742 MET B Protein S 3 FT #SUB 255 689 THR A 309 743 ALA B Protein S 1 FT #SUB 257 691 LYS A 125 559 GLU B Protein S 3 FT #SUB 257 691 LYS A 320 754 ALA B Protein B 1 FT #SUB 257 691 LYS A 321 755 ASN B Protein S 7 FT #SUB 258 692 LYS A 314 748 GLY B Protein S 5 FT #SUB 258 692 LYS A 316 750 ASN B Protein S 7 FT #SUB 258 692 LYS A 317 751 ALA B Protein S 4 FT #SUB 259 693 PRO A 311 745 SER B Protein B 4 FT #SUB 259 693 PRO A 312 746 ILE B Protein S 1 FT #SUB 260 694 ALA A 309 743 ALA B Protein A 4 FT #SUB 260 694 ALA A 310 744 GLY B Protein B 2 FT #SUB 261 695 ALA A 309 743 ALA B Protein A 4 FT #SUB 261 695 ALA A 310 744 GLY B Protein A 4 FT #SUB 262 696 ILE A 309 743 ALA B Protein A 5 FT #SUB 296 730 GLU A 161 595 ARG B Protein S 7 FT #SUB 296 730 GLU A 247 681 LEU B Protein B 1 FT #SUB 297 731 VAL A 247 681 LEU B Protein A 4 FT #SUB 297 731 VAL A 248 682 ALA B Protein S 1 FT #SUB 300 734 ASN A 161 595 ARG B Protein S 3 FT #SUB 300 734 ASN A 208 642 ASN B Protein S 4 FT #SUB 300 734 ASN A 210 644 TYR B Protein B 5 FT #SUB 300 734 ASN A 247 681 LEU B Protein S 2 FT #SUB 301 735 LYS A 250 684 SER B Protein S 7 FT #SUB 301 735 LYS A 251 685 GLY B Protein A 4 FT #SUB 301 735 LYS A 252 686 ASN B Protein A 13 FT #SUB 302 736 ASN A 252 686 ASN B Protein A 2 FT #SUB 304 738 VAL A 205 639 ALA B Protein S 1 FT #SUB 304 738 VAL A 210 644 TYR B Protein A 3 FT #SUB 305 739 GLY A 210 644 TYR B Protein B 4 FT #SUB 305 739 GLY A 251 685 GLY B Protein B 2 FT #SUB 305 739 GLY A 252 686 ASN B Protein B 1 FT #SUB 306 740 SER A 252 686 ASN B Protein A 4 FT #SUB 308 742 MET A 203 637 SER B Protein S 1 FT #SUB 308 742 MET A 204 638 ILE B Protein S 1 FT #SUB 308 742 MET A 210 644 TYR B Protein S 1 FT #SUB 308 742 MET A 253 687 TYR B Protein A 3 FT #SUB 309 743 ALA A 252 686 ASN B Protein S 1 FT #SUB 309 743 ALA A 253 687 TYR B Protein B 2 FT #SUB 309 743 ALA A 255 689 THR B Protein S 1 FT #SUB 309 743 ALA A 260 694 ALA B Protein B 3 FT #SUB 309 743 ALA A 261 695 ALA B Protein B 4 FT #SUB 309 743 ALA A 262 696 ILE B Protein A 5 FT #SUB 310 744 GLY A 260 694 ALA B Protein B 2 FT #SUB 310 744 GLY A 261 695 ALA B Protein B 4 FT #SUB 311 745 SER A 259 693 PRO B Protein A 4 FT #SUB 312 746 ILE A 259 693 PRO B Protein B 2 FT #SUB 314 748 GLY A 258 692 LYS B Protein B 5 FT #SUB 316 750 ASN A 252 686 ASN B Protein B 4 FT #SUB 316 750 ASN A 258 692 LYS B Protein A 8 FT #SUB 317 751 ALA A 258 692 LYS B Protein B 4 FT #SUB 320 754 ALA A 257 691 LYS B Protein S 1 FT #SUB 320 754 ALA A 335 769 ALA B Protein A 3 FT #SUB 320 754 ALA A 338 772 VAL B Protein S 1 FT #SUB 321 755 ASN A 257 691 LYS B Protein S 6 FT #SUB 321 755 ASN A 335 769 ALA B Protein A 2 FT #SUB 324 758 THR A 334 768 ALA B Protein S 2 FT #SUB 324 758 THR A 335 769 ALA B Protein S 4 FT #SUB 328 762 ILE A 100 534 MET B Protein B 1 FT #SUB 328 762 ILE A 102 536 ILE B Protein S 1 FT #SUB 329 763 ALA A 100 534 MET B Protein B 1 FT #SUB 333 767 ASP A 125 559 GLU B Protein S 2 FT #SUB 334 768 ALA A 324 758 THR B Protein A 2 FT #SUB 334 768 ALA A 337 771 ASN B Protein B 1 FT #SUB 335 769 ALA A 320 754 ALA B Protein A 3 FT #SUB 335 769 ALA A 321 755 ASN B Protein S 3 FT #SUB 335 769 ALA A 324 758 THR B Protein A 4 FT #SUB 337 771 ASN A 334 768 ALA B Protein S 1 FT #SUB 337 771 ASN A 337 771 ASN B Protein S 9 FT #SUB 337 771 ASN A 338 772 VAL B Protein B 1 FT #SUB 338 772 VAL A 320 754 ALA B Protein S 1 FT #SUB 341 775 SER A 338 772 VAL B Protein S 1 FT #SUB 374 808 GLY A 124 558 THR B Protein B 3 FT #SUB 377 811 LEU A 124 558 THR B Protein S 1 FT #SUB 378 812 LEU A 77 511 TYR B Protein A 6 FT #SUB 379 813 PRO A 77 511 TYR B Protein A 4 FT #SUB 379 813 PRO A 100 534 MET B Protein A 4 FT #SUB 379 813 PRO A 101 535 PRO B Protein S 2 FT #SUB 380 814 GLN A 100 534 MET B Protein A 9 FT #SUB 380 814 GLN A 101 535 PRO B Protein S 1 FT #SUB 380 814 GLN A 102 536 ILE B Protein S 1 FT #SUB 382 816 ALA A 74 508 SER B Protein A 4 FT #SUB 382 816 ALA A 78 512 LEU B Protein S 2 FT #SUB 383 817 CYS A 100 534 MET B Protein S 1 FT #SUB 385 819 GLN A 74 508 SER B Protein A 4 FT #SUB 386 820 MET A 65 499 LEU B Protein S 1 FT #SUB 386 820 MET A 69 503 LEU B Protein B 2 FT #SUB 386 820 MET A 74 508 SER B Protein B 2 FT #SUB 386 820 MET A 75 509 LEU B Protein S 2 FT #SUB 386 820 MET A 97 531 ILE B Protein S 2 FT #SUB 423 857 LEU A 247 681 LEU B Protein B 1 FT #SUB 423 857 LEU A 249 683 VAL B Protein S 1 FT #SUB 264 698 TRP A 307 741 ALA C Protein S 4 FT #SUB 264 698 TRP A 308 742 MET C Protein S 6 FT #SUB 265 699 ILE A 308 742 MET C Protein S 1 FT #SUB 265 699 ILE A 309 743 ALA C Protein S 1 FT #SUB 296 730 GLU A 348 782 GLU C Protein S 1 FT #SUB 299 733 ILE A 299 733 ILE C Protein S 1 FT #SUB 303 737 LEU A 304 738 VAL C Protein S 1 FT #SUB 304 738 VAL A 303 737 LEU C Protein S 1 FT #SUB 304 738 VAL A 344 778 ILE C Protein S 1 FT #SUB 304 738 VAL A 346 780 LEU C Protein S 1 FT #SUB 307 741 ALA A 264 698 TRP C Protein B 4 FT #SUB 307 741 ALA A 315 749 TYR C Protein A 6 FT #SUB 308 742 MET A 264 698 TRP C Protein A 5 FT #SUB 308 742 MET A 265 699 ILE C Protein B 1 FT #SUB 309 743 ALA A 265 699 ILE C Protein B 1 FT #SUB 310 744 GLY A 312 746 ILE C Protein B 3 FT #SUB 312 746 ILE A 310 744 GLY C Protein S 3 FT #SUB 312 746 ILE A 311 745 SER C Protein S 1 FT #SUB 312 746 ILE A 312 746 ILE C Protein S 3 FT #SUB 315 749 TYR A 307 741 ALA C Protein S 6 FT #SUB 315 749 TYR A 315 749 TYR C Protein S 5 FT #SUB 344 778 ILE A 304 738 VAL C Protein S 1 FT #SUB 346 780 LEU A 304 738 VAL C Protein S 1 FT #SUB 146 580 SER A 166 600 CYS D Protein S 1 FT #SUB 148 582 ARG A 166 600 CYS D Protein S 6 FT #SUB 148 582 ARG A 169 603 ALA D Protein S 1 FT #SUB 150 584 LEU A 169 603 ALA D Protein S 1 FT #SUB 150 584 LEU A 204 638 ILE D Protein S 3 FT #SUB 164 598 ARG A 275 709 GLU D Protein A 6 FT #SUB 165 599 ALA A 273 707 VAL D Protein S 1 FT #SUB 165 599 ALA A 275 709 GLU D Protein A 10 FT #SUB 165 599 ALA A 358 792 TYR D Protein A 2 FT #SUB 166 600 CYS A 146 580 SER D Protein S 1 FT #SUB 166 600 CYS A 148 582 ARG D Protein S 5 FT #SUB 166 600 CYS A 275 709 GLU D Protein A 5 FT #SUB 169 603 ALA A 148 582 ARG D Protein S 1 FT #SUB 169 603 ALA A 150 584 LEU D Protein S 1 FT #SUB 199 633 LYS A 199 633 LYS D Protein S 4 FT #SUB 201 635 HIS A 265 699 ILE D Protein S 4 FT #SUB 201 635 HIS A 266 700 GLU D Protein S 2 FT #SUB 203 637 SER A 265 699 ILE D Protein S 1 FT #SUB 204 638 ILE A 150 584 LEU D Protein S 3 FT #SUB 204 638 ILE A 273 707 VAL D Protein S 1 FT #SUB 204 638 ILE A 362 796 THR D Protein B 1 FT #SUB 205 639 ALA A 346 780 LEU D Protein A 3 FT #SUB 205 639 ALA A 362 796 THR D Protein B 2 FT #SUB 206 640 GLY A 273 707 VAL D Protein B 2 FT #SUB 206 640 GLY A 360 794 SER D Protein B 2 FT #SUB 206 640 GLY A 362 796 THR D Protein B 2 FT #SUB 207 641 ARG A 348 782 GLU D Protein S 10 FT #SUB 207 641 ARG A 358 792 TYR D Protein A 2 FT #SUB 261 695 ALA A 261 695 ALA D Protein S 1 FT #SUB 261 695 ALA A 265 699 ILE D Protein A 2 FT #SUB 262 696 ILE A 265 699 ILE D Protein A 4 FT #SUB 265 699 ILE A 201 635 HIS D Protein A 3 FT #SUB 265 699 ILE A 203 637 SER D Protein B 1 FT #SUB 265 699 ILE A 261 695 ALA D Protein S 2 FT #SUB 265 699 ILE A 262 696 ILE D Protein S 3 FT #SUB 266 700 GLU A 201 635 HIS D Protein S 6 FT #SUB 266 700 GLU A 266 700 GLU D Protein S 5 FT #SUB 273 707 VAL A 165 599 ALA D Protein S 1 FT #SUB 273 707 VAL A 206 640 GLY D Protein S 2 FT #SUB 275 709 GLU A 164 598 ARG D Protein S 8 FT #SUB 275 709 GLU A 165 599 ALA D Protein S 10 FT #SUB 275 709 GLU A 166 600 CYS D Protein S 4 FT #SUB 277 711 VAL A 164 598 ARG D Protein S 2 FT #SUB 346 780 LEU A 205 639 ALA D Protein S 3 FT #SUB 348 782 GLU A 207 641 ARG D Protein S 10 FT #SUB 358 792 TYR A 164 598 ARG D Protein S 1 FT #SUB 358 792 TYR A 165 599 ALA D Protein S 2 FT #SUB 358 792 TYR A 207 641 ARG D Protein S 2 FT #SUB 360 794 SER A 206 640 GLY D Protein S 2 FT #SUB 362 796 THR A 204 638 ILE D Protein S 1 FT #SUB 362 796 THR A 205 639 ALA D Protein S 2 FT #SUB 362 796 THR A 206 640 GLY D Protein S 2 FT #HET 125 559 GLU A 4 876 RIE B S 7 FT #HET 126 560 GLY A 4 876 RIE B B 1 FT #HET 127 561 CYS A 4 876 RIE B A 7 FT #HET 128 562 LEU A 4 876 RIE B B 2 FT #HET 130 564 ALA A 4 876 RIE B A 5 FT #HET 131 565 SER A 4 876 RIE B A 13 FT #HET 134 568 ARG A 4 876 RIE B S 2 FT #HET 156 590 ARG A 2 876 RIE A S 10 FT #HET 220 654 ALA A 1 1 SO4 A S 1 FT #HET 221 655 MET A 1 1 SO4 A A 4 FT #HET 222 656 GLY A 1 1 SO4 A B 6 FT #HET 223 657 MET A 1 1 SO4 A A 5 FT #HET 224 658 ASN A 1 1 SO4 A A 7 FT #HET 227 661 SER A 2 876 RIE A S 3 FT #HET 249 683 VAL A 2 876 RIE A S 3 FT #HET 250 684 SER A 2 876 RIE A S 6 FT #HET 252 686 ASN A 2 876 RIE A S 1 FT #HET 256 690 ASP A 2 876 RIE A S 6 FT #HET 257 691 LYS A 2 876 RIE A S 2 FT #HET 258 692 LYS A 2 876 RIE A S 3 FT #HET 301 735 LYS A 4 876 RIE B S 4 FT #HET 317 751 ALA A 4 876 RIE B B 3 FT #HET 318 752 HIS A 4 876 RIE B S 2 FT #HET 321 755 ASN A 4 876 RIE B S 4 FT #HET 419 853 LEU A 4 876 RIE B A 8 FT #HET 422 856 ALA A 4 876 RIE B S 5 FT #HET 423 857 LEU A 4 876 RIE B S 1 FT DISORDER 1 6 FT DISORDER 427 441 CC SEQUENCE 420 AA (ATOM); CC EPRPNEECLQ ILGNAEKGAK FLSDAEIIQL VNAKHIPAYK LETLIETHER GVSIRRQLLS CC KKLSEPSSLQ YLPYRDYNYS LVMGACCENV IGYMPIPVGV AGPLCLDEKE FQVPMATTEG CC CLVASTNRGC RAIGLGGGAS SRVLADGMTR GPVVRLPRAC DSAEVKAWLE TSEGFAVIKE CC AFDSTSRFAR LQKLHTSIAG RNLYIRFQSR SGDAMGMNMI SKGTEKALSK LHEYFPEMQI CC LAVSGNYCTD KKPAAINWIE GRGKSVVCEA VIPAKVVREV LKTTTEAMIE VNINKNLVGS CC AMAGSIGGYN AHAANIVTAI YIACGQDAAQ NVGSSNCITL MEASGPTNED LYISCTMPSI CC EIGTVGGGTN LLPQQACLQM LGVQGACKDN PGENARQLAR IVCGTVMAGE LSLMAALAAG CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES HHHHHHEPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETL CC ATOM ------EPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETL CC ******************************************** CC SEQRES IETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYM CC ATOM IETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYM CC ************************************************** CC SEQRES PIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVL CC ATOM PIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVL CC ************************************************** CC SEQRES ADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKL CC ATOM ADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKL CC ************************************************** CC SEQRES HTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVS CC ATOM HTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVS CC ************************************************** CC SEQRES GNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNIN CC ATOM GNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNIN CC ************************************************** CC SEQRES KNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEAS CC ATOM KNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEAS CC ************************************************** CC SEQRES GPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGEN CC ATOM GPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGEN CC ************************************************** CC SEQRES ARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKIN CC ATOM ARQLARIVCGTVMAGELSLMAALAAG--------------- CC ************************** SQ SEQUENCE 441 AA; MW; CN; HHHHHHEPRP NEECLQILGN AEKGAKFLSD AEIIQLVNAK HIPAYKLETL IETHERGVSI RRQLLSKKLS EPSSLQYLPY RDYNYSLVMG ACCENVIGYM PIPVGVAGPL CLDEKEFQVP MATTEGCLVA STNRGCRAIG LGGGASSRVL ADGMTRGPVV RLPRACDSAE VKAWLETSEG FAVIKEAFDS TSRFARLQKL HTSIAGRNLY IRFQSRSGDA MGMNMISKGT EKALSKLHEY FPEMQILAVS GNYCTDKKPA AINWIEGRGK SVVCEAVIPA KVVREVLKTT TEAMIEVNIN KNLVGSAMAG SIGGYNAHAA NIVTAIYIAC GQDAAQNVGS SNCITLMEAS GPTNEDLYIS CTMPSIEIGT VGGGTNLLPQ QACLQMLGVQ GACKDNPGEN ARQLARIVCG TVMAGELSLM AALAAGHLVK SHMIHNRSKI N // ID 2R4FB STANDARD; PRT; 441 AA. DT CONVERTED FROM PDB (SEQRES) 2R4F DE 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.700 CC R-Factor 0.215 FT #SUB 65 499 LEU B 106 540 VAL A Protein S 1 FT #SUB 65 499 LEU B 118 552 GLN A Protein S 4 FT #SUB 65 499 LEU B 386 820 MET A Protein S 1 FT #SUB 68 502 LYS B 118 552 GLN A Protein S 1 FT #SUB 69 503 LEU B 386 820 MET A Protein S 2 FT #SUB 74 508 SER B 382 816 ALA A Protein B 4 FT #SUB 74 508 SER B 385 819 GLN A Protein S 4 FT #SUB 74 508 SER B 386 820 MET A Protein S 2 FT #SUB 75 509 LEU B 386 820 MET A Protein S 2 FT #SUB 77 511 TYR B 378 812 LEU A Protein S 6 FT #SUB 77 511 TYR B 379 813 PRO A Protein B 4 FT #SUB 78 512 LEU B 382 816 ALA A Protein A 2 FT #SUB 83 517 TYR B 101 535 PRO A Protein S 1 FT #SUB 83 517 TYR B 103 537 PRO A Protein S 1 FT #SUB 88 522 VAL B 103 537 PRO A Protein S 3 FT #SUB 91 525 ALA B 126 560 GLY A Protein B 3 FT #SUB 92 526 CYS B 123 557 THR A Protein B 1 FT #SUB 92 526 CYS B 124 558 THR A Protein A 12 FT #SUB 92 526 CYS B 125 559 GLU A Protein B 5 FT #SUB 92 526 CYS B 126 560 GLY A Protein B 5 FT #SUB 93 527 CYS B 103 537 PRO A Protein S 1 FT #SUB 93 527 CYS B 105 539 GLY A Protein S 2 FT #SUB 93 527 CYS B 123 557 THR A Protein S 1 FT #SUB 93 527 CYS B 129 563 VAL A Protein S 1 FT #SUB 94 528 GLU B 105 539 GLY A Protein B 1 FT #SUB 94 528 GLU B 126 560 GLY A Protein S 2 FT #SUB 94 528 GLU B 127 561 CYS A Protein S 8 FT #SUB 94 528 GLU B 128 562 LEU A Protein S 1 FT #SUB 94 528 GLU B 129 563 VAL A Protein A 7 FT #SUB 94 528 GLU B 130 564 ALA A Protein S 6 FT #SUB 95 529 ASN B 105 539 GLY A Protein B 3 FT #SUB 95 529 ASN B 106 540 VAL A Protein A 8 FT #SUB 95 529 ASN B 133 567 ASN A Protein S 2 FT #SUB 96 530 VAL B 104 538 VAL A Protein A 4 FT #SUB 97 531 ILE B 104 538 VAL A Protein A 4 FT #SUB 97 531 ILE B 106 540 VAL A Protein S 1 FT #SUB 97 531 ILE B 386 820 MET A Protein S 2 FT #SUB 98 532 GLY B 103 537 PRO A Protein B 2 FT #SUB 98 532 GLY B 104 538 VAL A Protein B 6 FT #SUB 99 533 TYR B 99 533 TYR A Protein S 2 FT #SUB 99 533 TYR B 101 535 PRO A Protein S 2 FT #SUB 99 533 TYR B 102 536 ILE A Protein A 3 FT #SUB 99 533 TYR B 104 538 VAL A Protein B 1 FT #SUB 100 534 MET B 100 534 MET A Protein B 2 FT #SUB 100 534 MET B 101 535 PRO A Protein B 2 FT #SUB 100 534 MET B 102 536 ILE A Protein A 11 FT #SUB 100 534 MET B 104 538 VAL A Protein A 2 FT #SUB 100 534 MET B 328 762 ILE A Protein S 1 FT #SUB 100 534 MET B 329 763 ALA A Protein S 1 FT #SUB 100 534 MET B 379 813 PRO A Protein S 4 FT #SUB 100 534 MET B 380 814 GLN A Protein S 9 FT #SUB 100 534 MET B 383 817 CYS A Protein S 1 FT #SUB 101 535 PRO B 83 517 TYR A Protein S 2 FT #SUB 101 535 PRO B 99 533 TYR A Protein S 2 FT #SUB 101 535 PRO B 100 534 MET A Protein B 2 FT #SUB 101 535 PRO B 379 813 PRO A Protein S 2 FT #SUB 101 535 PRO B 380 814 GLN A Protein B 1 FT #SUB 102 536 ILE B 99 533 TYR A Protein B 3 FT #SUB 102 536 ILE B 100 534 MET A Protein A 11 FT #SUB 102 536 ILE B 102 536 ILE A Protein S 1 FT #SUB 102 536 ILE B 328 762 ILE A Protein S 1 FT #SUB 102 536 ILE B 380 814 GLN A Protein S 1 FT #SUB 103 537 PRO B 83 517 TYR A Protein S 1 FT #SUB 103 537 PRO B 88 522 VAL A Protein S 3 FT #SUB 103 537 PRO B 93 527 CYS A Protein S 1 FT #SUB 103 537 PRO B 98 532 GLY A Protein B 2 FT #SUB 104 538 VAL B 96 530 VAL A Protein B 4 FT #SUB 104 538 VAL B 97 531 ILE A Protein A 5 FT #SUB 104 538 VAL B 98 532 GLY A Protein A 6 FT #SUB 104 538 VAL B 99 533 TYR A Protein S 2 FT #SUB 104 538 VAL B 100 534 MET A Protein S 2 FT #SUB 105 539 GLY B 93 527 CYS A Protein B 2 FT #SUB 105 539 GLY B 94 528 GLU A Protein B 1 FT #SUB 105 539 GLY B 95 529 ASN A Protein B 3 FT #SUB 106 540 VAL B 65 499 LEU A Protein S 1 FT #SUB 106 540 VAL B 95 529 ASN A Protein A 7 FT #SUB 106 540 VAL B 97 531 ILE A Protein S 1 FT #SUB 118 552 GLN B 65 499 LEU A Protein S 3 FT #SUB 118 552 GLN B 68 502 LYS A Protein S 1 FT #SUB 123 557 THR B 92 526 CYS A Protein B 1 FT #SUB 124 558 THR B 92 526 CYS A Protein B 12 FT #SUB 124 558 THR B 374 808 GLY A Protein S 3 FT #SUB 124 558 THR B 377 811 LEU A Protein S 1 FT #SUB 125 559 GLU B 92 526 CYS A Protein B 5 FT #SUB 125 559 GLU B 257 691 LYS A Protein S 3 FT #SUB 125 559 GLU B 333 767 ASP A Protein S 2 FT #SUB 126 560 GLY B 91 525 ALA A Protein B 3 FT #SUB 126 560 GLY B 92 526 CYS A Protein B 5 FT #SUB 126 560 GLY B 94 528 GLU A Protein B 2 FT #SUB 127 561 CYS B 94 528 GLU A Protein B 8 FT #SUB 128 562 LEU B 94 528 GLU A Protein B 1 FT #SUB 129 563 VAL B 93 527 CYS A Protein S 1 FT #SUB 129 563 VAL B 94 528 GLU A Protein A 6 FT #SUB 129 563 VAL B 95 529 ASN A Protein S 1 FT #SUB 130 564 ALA B 94 528 GLU A Protein A 6 FT #SUB 161 595 ARG B 296 730 GLU A Protein S 7 FT #SUB 161 595 ARG B 300 734 ASN A Protein S 3 FT #SUB 203 637 SER B 308 742 MET A Protein S 1 FT #SUB 204 638 ILE B 308 742 MET A Protein B 1 FT #SUB 205 639 ALA B 304 738 VAL A Protein S 1 FT #SUB 208 642 ASN B 300 734 ASN A Protein S 4 FT #SUB 210 644 TYR B 300 734 ASN A Protein S 5 FT #SUB 210 644 TYR B 304 738 VAL A Protein S 3 FT #SUB 210 644 TYR B 305 739 GLY A Protein S 4 FT #SUB 210 644 TYR B 308 742 MET A Protein S 1 FT #SUB 247 681 LEU B 296 730 GLU A Protein S 1 FT #SUB 247 681 LEU B 297 731 VAL A Protein A 4 FT #SUB 247 681 LEU B 300 734 ASN A Protein S 2 FT #SUB 247 681 LEU B 423 857 LEU A Protein B 1 FT #SUB 248 682 ALA B 297 731 VAL A Protein S 1 FT #SUB 249 683 VAL B 423 857 LEU A Protein S 1 FT #SUB 250 684 SER B 301 735 LYS A Protein A 7 FT #SUB 251 685 GLY B 301 735 LYS A Protein B 4 FT #SUB 251 685 GLY B 305 739 GLY A Protein B 2 FT #SUB 252 686 ASN B 301 735 LYS A Protein A 13 FT #SUB 252 686 ASN B 302 736 ASN A Protein S 2 FT #SUB 252 686 ASN B 305 739 GLY A Protein B 1 FT #SUB 252 686 ASN B 306 740 SER A Protein S 4 FT #SUB 252 686 ASN B 309 743 ALA A Protein B 1 FT #SUB 252 686 ASN B 316 750 ASN A Protein S 4 FT #SUB 253 687 TYR B 308 742 MET A Protein S 3 FT #SUB 253 687 TYR B 309 743 ALA A Protein S 2 FT #SUB 255 689 THR B 309 743 ALA A Protein S 1 FT #SUB 257 691 LYS B 125 559 GLU A Protein S 3 FT #SUB 257 691 LYS B 320 754 ALA A Protein B 1 FT #SUB 257 691 LYS B 321 755 ASN A Protein S 6 FT #SUB 258 692 LYS B 314 748 GLY A Protein S 5 FT #SUB 258 692 LYS B 316 750 ASN A Protein S 8 FT #SUB 258 692 LYS B 317 751 ALA A Protein S 4 FT #SUB 259 693 PRO B 311 745 SER A Protein B 4 FT #SUB 259 693 PRO B 312 746 ILE A Protein S 2 FT #SUB 260 694 ALA B 309 743 ALA A Protein A 3 FT #SUB 260 694 ALA B 310 744 GLY A Protein B 2 FT #SUB 261 695 ALA B 309 743 ALA A Protein A 4 FT #SUB 261 695 ALA B 310 744 GLY A Protein A 4 FT #SUB 262 696 ILE B 309 743 ALA A Protein A 5 FT #SUB 296 730 GLU B 161 595 ARG A Protein S 8 FT #SUB 296 730 GLU B 247 681 LEU A Protein B 1 FT #SUB 297 731 VAL B 247 681 LEU A Protein S 2 FT #SUB 300 734 ASN B 161 595 ARG A Protein S 1 FT #SUB 300 734 ASN B 208 642 ASN A Protein S 4 FT #SUB 300 734 ASN B 210 644 TYR A Protein B 5 FT #SUB 300 734 ASN B 247 681 LEU A Protein S 3 FT #SUB 301 735 LYS B 250 684 SER A Protein S 7 FT #SUB 301 735 LYS B 251 685 GLY A Protein A 4 FT #SUB 301 735 LYS B 252 686 ASN A Protein A 13 FT #SUB 302 736 ASN B 252 686 ASN A Protein A 2 FT #SUB 304 738 VAL B 205 639 ALA A Protein S 1 FT #SUB 304 738 VAL B 210 644 TYR A Protein A 4 FT #SUB 305 739 GLY B 210 644 TYR A Protein B 4 FT #SUB 305 739 GLY B 251 685 GLY A Protein B 2 FT #SUB 305 739 GLY B 252 686 ASN A Protein B 1 FT #SUB 306 740 SER B 252 686 ASN A Protein A 4 FT #SUB 308 742 MET B 204 638 ILE A Protein S 1 FT #SUB 308 742 MET B 210 644 TYR A Protein S 1 FT #SUB 308 742 MET B 253 687 TYR A Protein A 3 FT #SUB 309 743 ALA B 252 686 ASN A Protein S 1 FT #SUB 309 743 ALA B 255 689 THR A Protein S 1 FT #SUB 309 743 ALA B 260 694 ALA A Protein A 4 FT #SUB 309 743 ALA B 261 695 ALA A Protein B 4 FT #SUB 309 743 ALA B 262 696 ILE A Protein A 5 FT #SUB 310 744 GLY B 260 694 ALA A Protein B 2 FT #SUB 310 744 GLY B 261 695 ALA A Protein B 4 FT #SUB 311 745 SER B 259 693 PRO A Protein A 4 FT #SUB 312 746 ILE B 259 693 PRO A Protein B 1 FT #SUB 314 748 GLY B 258 692 LYS A Protein B 5 FT #SUB 316 750 ASN B 252 686 ASN A Protein B 4 FT #SUB 316 750 ASN B 258 692 LYS A Protein A 7 FT #SUB 317 751 ALA B 258 692 LYS A Protein B 4 FT #SUB 320 754 ALA B 257 691 LYS A Protein S 1 FT #SUB 320 754 ALA B 335 769 ALA A Protein A 3 FT #SUB 320 754 ALA B 338 772 VAL A Protein S 1 FT #SUB 321 755 ASN B 257 691 LYS A Protein S 7 FT #SUB 321 755 ASN B 335 769 ALA A Protein A 3 FT #SUB 324 758 THR B 334 768 ALA A Protein S 2 FT #SUB 324 758 THR B 335 769 ALA A Protein S 4 FT #SUB 328 762 ILE B 100 534 MET A Protein B 1 FT #SUB 328 762 ILE B 102 536 ILE A Protein S 1 FT #SUB 329 763 ALA B 100 534 MET A Protein B 1 FT #SUB 333 767 ASP B 125 559 GLU A Protein S 2 FT #SUB 334 768 ALA B 324 758 THR A Protein A 2 FT #SUB 334 768 ALA B 337 771 ASN A Protein B 1 FT #SUB 335 769 ALA B 320 754 ALA A Protein A 3 FT #SUB 335 769 ALA B 321 755 ASN A Protein S 2 FT #SUB 335 769 ALA B 324 758 THR A Protein A 4 FT #SUB 337 771 ASN B 334 768 ALA A Protein S 1 FT #SUB 337 771 ASN B 337 771 ASN A Protein S 9 FT #SUB 338 772 VAL B 320 754 ALA A Protein S 1 FT #SUB 338 772 VAL B 337 771 ASN A Protein S 1 FT #SUB 338 772 VAL B 341 775 SER A Protein S 1 FT #SUB 374 808 GLY B 124 558 THR A Protein B 3 FT #SUB 377 811 LEU B 124 558 THR A Protein S 1 FT #SUB 378 812 LEU B 77 511 TYR A Protein A 3 FT #SUB 379 813 PRO B 77 511 TYR A Protein A 4 FT #SUB 379 813 PRO B 100 534 MET A Protein A 4 FT #SUB 379 813 PRO B 101 535 PRO A Protein S 1 FT #SUB 380 814 GLN B 100 534 MET A Protein A 9 FT #SUB 380 814 GLN B 101 535 PRO A Protein S 1 FT #SUB 380 814 GLN B 102 536 ILE A Protein S 1 FT #SUB 382 816 ALA B 74 508 SER A Protein A 4 FT #SUB 382 816 ALA B 78 512 LEU A Protein S 2 FT #SUB 383 817 CYS B 100 534 MET A Protein S 1 FT #SUB 385 819 GLN B 74 508 SER A Protein A 5 FT #SUB 386 820 MET B 65 499 LEU A Protein S 1 FT #SUB 386 820 MET B 69 503 LEU A Protein B 2 FT #SUB 386 820 MET B 74 508 SER A Protein B 1 FT #SUB 386 820 MET B 75 509 LEU A Protein S 2 FT #SUB 386 820 MET B 97 531 ILE A Protein S 2 FT #SUB 423 857 LEU B 247 681 LEU A Protein B 1 FT #SUB 423 857 LEU B 249 683 VAL A Protein S 1 FT #SUB 146 580 SER B 166 600 CYS C Protein S 1 FT #SUB 148 582 ARG B 166 600 CYS C Protein S 6 FT #SUB 148 582 ARG B 169 603 ALA C Protein S 1 FT #SUB 150 584 LEU B 169 603 ALA C Protein S 1 FT #SUB 150 584 LEU B 204 638 ILE C Protein S 3 FT #SUB 161 595 ARG B 348 782 GLU C Protein S 3 FT #SUB 164 598 ARG B 275 709 GLU C Protein A 6 FT #SUB 165 599 ALA B 273 707 VAL C Protein S 1 FT #SUB 165 599 ALA B 275 709 GLU C Protein A 10 FT #SUB 165 599 ALA B 358 792 TYR C Protein A 2 FT #SUB 166 600 CYS B 146 580 SER C Protein S 1 FT #SUB 166 600 CYS B 148 582 ARG C Protein S 5 FT #SUB 166 600 CYS B 275 709 GLU C Protein A 5 FT #SUB 169 603 ALA B 148 582 ARG C Protein S 1 FT #SUB 169 603 ALA B 150 584 LEU C Protein S 1 FT #SUB 199 633 LYS B 199 633 LYS C Protein S 5 FT #SUB 201 635 HIS B 265 699 ILE C Protein S 4 FT #SUB 201 635 HIS B 266 700 GLU C Protein S 2 FT #SUB 204 638 ILE B 150 584 LEU C Protein S 3 FT #SUB 204 638 ILE B 273 707 VAL C Protein S 1 FT #SUB 204 638 ILE B 362 796 THR C Protein B 2 FT #SUB 205 639 ALA B 346 780 LEU C Protein A 3 FT #SUB 205 639 ALA B 362 796 THR C Protein B 2 FT #SUB 206 640 GLY B 273 707 VAL C Protein B 2 FT #SUB 206 640 GLY B 360 794 SER C Protein B 2 FT #SUB 206 640 GLY B 362 796 THR C Protein B 2 FT #SUB 207 641 ARG B 348 782 GLU C Protein S 10 FT #SUB 207 641 ARG B 358 792 TYR C Protein A 2 FT #SUB 261 695 ALA B 261 695 ALA C Protein S 1 FT #SUB 261 695 ALA B 265 699 ILE C Protein A 2 FT #SUB 262 696 ILE B 265 699 ILE C Protein A 4 FT #SUB 265 699 ILE B 201 635 HIS C Protein A 3 FT #SUB 265 699 ILE B 261 695 ALA C Protein S 2 FT #SUB 265 699 ILE B 262 696 ILE C Protein S 4 FT #SUB 266 700 GLU B 201 635 HIS C Protein S 6 FT #SUB 266 700 GLU B 266 700 GLU C Protein S 5 FT #SUB 273 707 VAL B 165 599 ALA C Protein S 1 FT #SUB 273 707 VAL B 206 640 GLY C Protein S 2 FT #SUB 275 709 GLU B 164 598 ARG C Protein S 6 FT #SUB 275 709 GLU B 165 599 ALA C Protein S 10 FT #SUB 275 709 GLU B 166 600 CYS C Protein S 4 FT #SUB 346 780 LEU B 205 639 ALA C Protein S 3 FT #SUB 348 782 GLU B 207 641 ARG C Protein S 9 FT #SUB 358 792 TYR B 165 599 ALA C Protein S 2 FT #SUB 358 792 TYR B 207 641 ARG C Protein S 3 FT #SUB 360 794 SER B 206 640 GLY C Protein S 2 FT #SUB 362 796 THR B 204 638 ILE C Protein S 1 FT #SUB 362 796 THR B 205 639 ALA C Protein S 2 FT #SUB 362 796 THR B 206 640 GLY C Protein S 2 FT #SUB 264 698 TRP B 307 741 ALA D Protein S 4 FT #SUB 264 698 TRP B 308 742 MET D Protein S 6 FT #SUB 265 699 ILE B 308 742 MET D Protein S 1 FT #SUB 265 699 ILE B 309 743 ALA D Protein S 1 FT #SUB 299 733 ILE B 299 733 ILE D Protein S 1 FT #SUB 303 737 LEU B 304 738 VAL D Protein S 1 FT #SUB 304 738 VAL B 303 737 LEU D Protein S 1 FT #SUB 304 738 VAL B 344 778 ILE D Protein S 1 FT #SUB 304 738 VAL B 346 780 LEU D Protein S 1 FT #SUB 307 741 ALA B 264 698 TRP D Protein B 4 FT #SUB 307 741 ALA B 315 749 TYR D Protein A 6 FT #SUB 308 742 MET B 264 698 TRP D Protein A 5 FT #SUB 308 742 MET B 265 699 ILE D Protein B 1 FT #SUB 309 743 ALA B 265 699 ILE D Protein B 1 FT #SUB 310 744 GLY B 312 746 ILE D Protein B 3 FT #SUB 312 746 ILE B 310 744 GLY D Protein S 3 FT #SUB 312 746 ILE B 312 746 ILE D Protein S 3 FT #SUB 315 749 TYR B 307 741 ALA D Protein S 6 FT #SUB 315 749 TYR B 315 749 TYR D Protein S 4 FT #SUB 344 778 ILE B 304 738 VAL D Protein S 1 FT #SUB 346 780 LEU B 304 738 VAL D Protein S 1 FT #HET 125 559 GLU B 2 876 RIE A S 7 FT #HET 126 560 GLY B 2 876 RIE A B 1 FT #HET 127 561 CYS B 2 876 RIE A A 7 FT #HET 128 562 LEU B 2 876 RIE A B 2 FT #HET 130 564 ALA B 2 876 RIE A A 5 FT #HET 131 565 SER B 2 876 RIE A A 13 FT #HET 134 568 ARG B 2 876 RIE A S 2 FT #HET 156 590 ARG B 4 876 RIE B S 10 FT #HET 220 654 ALA B 3 2 SO4 B S 1 FT #HET 221 655 MET B 3 2 SO4 B A 4 FT #HET 222 656 GLY B 3 2 SO4 B B 5 FT #HET 223 657 MET B 3 2 SO4 B A 5 FT #HET 224 658 ASN B 3 2 SO4 B A 2 FT #HET 227 661 SER B 4 876 RIE B S 3 FT #HET 249 683 VAL B 4 876 RIE B S 3 FT #HET 250 684 SER B 4 876 RIE B S 6 FT #HET 252 686 ASN B 4 876 RIE B S 1 FT #HET 256 690 ASP B 4 876 RIE B S 6 FT #HET 257 691 LYS B 4 876 RIE B S 2 FT #HET 258 692 LYS B 4 876 RIE B S 3 FT #HET 301 735 LYS B 2 876 RIE A S 4 FT #HET 317 751 ALA B 2 876 RIE A B 3 FT #HET 318 752 HIS B 2 876 RIE A S 2 FT #HET 321 755 ASN B 2 876 RIE A S 4 FT #HET 419 853 LEU B 2 876 RIE A A 8 FT #HET 422 856 ALA B 2 876 RIE A S 5 FT #HET 423 857 LEU B 2 876 RIE A S 2 FT DISORDER 1 6 FT DISORDER 19 24 FT DISORDER 41 49 FT DISORDER 427 441 CC SEQUENCE 405 AA (ATOM); CC EPRPNEECLQ ILAKFLSDAE IIQLVNAKLI ETHERGVSIR RQLLSKKLSE PSSLQYLPYR CC DYNYSLVMGA CCENVIGYMP IPVGVAGPLC LDEKEFQVPM ATTEGCLVAS TNRGCRAIGL CC GGGASSRVLA DGMTRGPVVR LPRACDSAEV KAWLETSEGF AVIKEAFDST SRFARLQKLH CC TSIAGRNLYI RFQSRSGDAM GMNMISKGTE KALSKLHEYF PEMQILAVSG NYCTDKKPAA CC INWIEGRGKS VVCEAVIPAK VVREVLKTTT EAMIEVNINK NLVGSAMAGS IGGYNAHAAN CC IVTAIYIACG QDAAQNVGSS NCITLMEASG PTNEDLYISC TMPSIEIGTV GGGTNLLPQQ CC ACLQMLGVQG ACKDNPGENA RQLARIVCGT VMAGELSLMA ALAAG CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES HHHHHHEPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETL CC ATOM ------EPRPNEECLQIL------AKFLSDAEIIQLVNAK---------L CC ************ **************** * CC SEQRES IETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYM CC ATOM IETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYM CC ************************************************** CC SEQRES PIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVL CC ATOM PIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVL CC ************************************************** CC SEQRES ADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKL CC ATOM ADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKL CC ************************************************** CC SEQRES HTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVS CC ATOM HTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVS CC ************************************************** CC SEQRES GNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNIN CC ATOM GNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNIN CC ************************************************** CC SEQRES KNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEAS CC ATOM KNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEAS CC ************************************************** CC SEQRES GPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGEN CC ATOM GPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGEN CC ************************************************** CC SEQRES ARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKIN CC ATOM ARQLARIVCGTVMAGELSLMAALAAG--------------- CC ************************** SQ SEQUENCE 441 AA; MW; CN; HHHHHHEPRP NEECLQILGN AEKGAKFLSD AEIIQLVNAK HIPAYKLETL IETHERGVSI RRQLLSKKLS EPSSLQYLPY RDYNYSLVMG ACCENVIGYM PIPVGVAGPL CLDEKEFQVP MATTEGCLVA STNRGCRAIG LGGGASSRVL ADGMTRGPVV RLPRACDSAE VKAWLETSEG FAVIKEAFDS TSRFARLQKL HTSIAGRNLY IRFQSRSGDA MGMNMISKGT EKALSKLHEY FPEMQILAVS GNYCTDKKPA AINWIEGRGK SVVCEAVIPA KVVREVLKTT TEAMIEVNIN KNLVGSAMAG SIGGYNAHAA NIVTAIYIAC GQDAAQNVGS SNCITLMEAS GPTNEDLYIS CTMPSIEIGT VGGGTNLLPQ QACLQMLGVQ GACKDNPGEN ARQLARIVCG TVMAGELSLM AALAAGHLVK SHMIHNRSKI N // ID 2R4FC STANDARD; PRT; 441 AA. DT CONVERTED FROM PDB (SEQRES) 2R4F DE 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.700 CC R-Factor 0.215 FT #SUB 264 698 TRP C 307 741 ALA A Protein S 4 FT #SUB 264 698 TRP C 308 742 MET A Protein S 5 FT #SUB 265 699 ILE C 308 742 MET A Protein S 1 FT #SUB 265 699 ILE C 309 743 ALA A Protein S 1 FT #SUB 299 733 ILE C 299 733 ILE A Protein S 1 FT #SUB 303 737 LEU C 304 738 VAL A Protein S 1 FT #SUB 304 738 VAL C 303 737 LEU A Protein S 1 FT #SUB 304 738 VAL C 344 778 ILE A Protein S 1 FT #SUB 304 738 VAL C 346 780 LEU A Protein S 1 FT #SUB 307 741 ALA C 264 698 TRP A Protein B 4 FT #SUB 307 741 ALA C 315 749 TYR A Protein A 6 FT #SUB 308 742 MET C 264 698 TRP A Protein A 6 FT #SUB 308 742 MET C 265 699 ILE A Protein B 1 FT #SUB 309 743 ALA C 265 699 ILE A Protein B 1 FT #SUB 310 744 GLY C 312 746 ILE A Protein B 3 FT #SUB 311 745 SER C 312 746 ILE A Protein B 1 FT #SUB 312 746 ILE C 310 744 GLY A Protein S 3 FT #SUB 312 746 ILE C 312 746 ILE A Protein S 3 FT #SUB 315 749 TYR C 307 741 ALA A Protein S 6 FT #SUB 315 749 TYR C 315 749 TYR A Protein S 5 FT #SUB 344 778 ILE C 304 738 VAL A Protein S 1 FT #SUB 346 780 LEU C 304 738 VAL A Protein S 1 FT #SUB 348 782 GLU C 296 730 GLU A Protein S 1 FT #SUB 146 580 SER C 166 600 CYS B Protein S 1 FT #SUB 148 582 ARG C 166 600 CYS B Protein S 5 FT #SUB 148 582 ARG C 169 603 ALA B Protein S 1 FT #SUB 150 584 LEU C 169 603 ALA B Protein S 1 FT #SUB 150 584 LEU C 204 638 ILE B Protein S 3 FT #SUB 164 598 ARG C 275 709 GLU B Protein A 6 FT #SUB 165 599 ALA C 273 707 VAL B Protein S 1 FT #SUB 165 599 ALA C 275 709 GLU B Protein A 10 FT #SUB 165 599 ALA C 358 792 TYR B Protein A 2 FT #SUB 166 600 CYS C 146 580 SER B Protein S 1 FT #SUB 166 600 CYS C 148 582 ARG B Protein S 6 FT #SUB 166 600 CYS C 275 709 GLU B Protein A 4 FT #SUB 169 603 ALA C 148 582 ARG B Protein S 1 FT #SUB 169 603 ALA C 150 584 LEU B Protein S 1 FT #SUB 199 633 LYS C 199 633 LYS B Protein S 5 FT #SUB 201 635 HIS C 265 699 ILE B Protein S 3 FT #SUB 201 635 HIS C 266 700 GLU B Protein S 6 FT #SUB 204 638 ILE C 150 584 LEU B Protein S 3 FT #SUB 204 638 ILE C 362 796 THR B Protein B 1 FT #SUB 205 639 ALA C 346 780 LEU B Protein A 3 FT #SUB 205 639 ALA C 362 796 THR B Protein B 2 FT #SUB 206 640 GLY C 273 707 VAL B Protein B 2 FT #SUB 206 640 GLY C 360 794 SER B Protein B 2 FT #SUB 206 640 GLY C 362 796 THR B Protein B 2 FT #SUB 207 641 ARG C 348 782 GLU B Protein S 9 FT #SUB 207 641 ARG C 358 792 TYR B Protein A 3 FT #SUB 261 695 ALA C 261 695 ALA B Protein S 1 FT #SUB 261 695 ALA C 265 699 ILE B Protein A 2 FT #SUB 262 696 ILE C 265 699 ILE B Protein A 4 FT #SUB 265 699 ILE C 201 635 HIS B Protein A 4 FT #SUB 265 699 ILE C 261 695 ALA B Protein S 2 FT #SUB 265 699 ILE C 262 696 ILE B Protein S 4 FT #SUB 266 700 GLU C 201 635 HIS B Protein S 2 FT #SUB 266 700 GLU C 266 700 GLU B Protein S 5 FT #SUB 273 707 VAL C 165 599 ALA B Protein S 1 FT #SUB 273 707 VAL C 204 638 ILE B Protein S 1 FT #SUB 273 707 VAL C 206 640 GLY B Protein S 2 FT #SUB 275 709 GLU C 164 598 ARG B Protein S 6 FT #SUB 275 709 GLU C 165 599 ALA B Protein S 10 FT #SUB 275 709 GLU C 166 600 CYS B Protein S 5 FT #SUB 346 780 LEU C 205 639 ALA B Protein S 3 FT #SUB 348 782 GLU C 161 595 ARG B Protein S 3 FT #SUB 348 782 GLU C 207 641 ARG B Protein S 10 FT #SUB 358 792 TYR C 165 599 ALA B Protein S 2 FT #SUB 358 792 TYR C 207 641 ARG B Protein S 2 FT #SUB 360 794 SER C 206 640 GLY B Protein S 2 FT #SUB 362 796 THR C 204 638 ILE B Protein S 2 FT #SUB 362 796 THR C 205 639 ALA B Protein S 2 FT #SUB 362 796 THR C 206 640 GLY B Protein S 2 FT #SUB 65 499 LEU C 106 540 VAL D Protein S 1 FT #SUB 65 499 LEU C 118 552 GLN D Protein S 4 FT #SUB 65 499 LEU C 386 820 MET D Protein S 1 FT #SUB 68 502 LYS C 118 552 GLN D Protein S 1 FT #SUB 69 503 LEU C 118 552 GLN D Protein S 1 FT #SUB 69 503 LEU C 386 820 MET D Protein S 1 FT #SUB 74 508 SER C 382 816 ALA D Protein A 5 FT #SUB 74 508 SER C 385 819 GLN D Protein A 7 FT #SUB 74 508 SER C 386 820 MET D Protein S 3 FT #SUB 75 509 LEU C 386 820 MET D Protein S 1 FT #SUB 77 511 TYR C 378 812 LEU D Protein S 6 FT #SUB 77 511 TYR C 379 813 PRO D Protein B 4 FT #SUB 78 512 LEU C 382 816 ALA D Protein A 2 FT #SUB 78 512 LEU C 383 817 CYS D Protein S 1 FT #SUB 83 517 TYR C 101 535 PRO D Protein S 2 FT #SUB 83 517 TYR C 103 537 PRO D Protein S 1 FT #SUB 88 522 VAL C 103 537 PRO D Protein S 3 FT #SUB 91 525 ALA C 126 560 GLY D Protein B 2 FT #SUB 92 526 CYS C 123 557 THR D Protein B 1 FT #SUB 92 526 CYS C 124 558 THR D Protein A 11 FT #SUB 92 526 CYS C 125 559 GLU D Protein B 5 FT #SUB 92 526 CYS C 126 560 GLY D Protein B 5 FT #SUB 93 527 CYS C 103 537 PRO D Protein S 1 FT #SUB 93 527 CYS C 105 539 GLY D Protein S 2 FT #SUB 93 527 CYS C 123 557 THR D Protein S 1 FT #SUB 93 527 CYS C 129 563 VAL D Protein S 1 FT #SUB 94 528 GLU C 105 539 GLY D Protein B 1 FT #SUB 94 528 GLU C 126 560 GLY D Protein S 2 FT #SUB 94 528 GLU C 127 561 CYS D Protein S 8 FT #SUB 94 528 GLU C 128 562 LEU D Protein S 1 FT #SUB 94 528 GLU C 129 563 VAL D Protein A 6 FT #SUB 94 528 GLU C 130 564 ALA D Protein S 6 FT #SUB 95 529 ASN C 105 539 GLY D Protein B 3 FT #SUB 95 529 ASN C 106 540 VAL D Protein A 8 FT #SUB 95 529 ASN C 133 567 ASN D Protein S 2 FT #SUB 96 530 VAL C 104 538 VAL D Protein A 3 FT #SUB 97 531 ILE C 104 538 VAL D Protein A 4 FT #SUB 97 531 ILE C 106 540 VAL D Protein S 1 FT #SUB 97 531 ILE C 386 820 MET D Protein S 2 FT #SUB 98 532 GLY C 103 537 PRO D Protein B 2 FT #SUB 98 532 GLY C 104 538 VAL D Protein B 6 FT #SUB 99 533 TYR C 99 533 TYR D Protein S 2 FT #SUB 99 533 TYR C 101 535 PRO D Protein S 2 FT #SUB 99 533 TYR C 102 536 ILE D Protein A 3 FT #SUB 99 533 TYR C 104 538 VAL D Protein B 1 FT #SUB 100 534 MET C 100 534 MET D Protein B 2 FT #SUB 100 534 MET C 101 535 PRO D Protein B 2 FT #SUB 100 534 MET C 102 536 ILE D Protein A 11 FT #SUB 100 534 MET C 104 538 VAL D Protein A 2 FT #SUB 100 534 MET C 328 762 ILE D Protein S 1 FT #SUB 100 534 MET C 329 763 ALA D Protein S 2 FT #SUB 100 534 MET C 379 813 PRO D Protein S 4 FT #SUB 100 534 MET C 380 814 GLN D Protein S 8 FT #SUB 100 534 MET C 383 817 CYS D Protein S 1 FT #SUB 101 535 PRO C 83 517 TYR D Protein S 1 FT #SUB 101 535 PRO C 99 533 TYR D Protein S 1 FT #SUB 101 535 PRO C 100 534 MET D Protein B 2 FT #SUB 101 535 PRO C 379 813 PRO D Protein S 1 FT #SUB 101 535 PRO C 380 814 GLN D Protein B 1 FT #SUB 102 536 ILE C 99 533 TYR D Protein B 3 FT #SUB 102 536 ILE C 100 534 MET D Protein A 11 FT #SUB 102 536 ILE C 102 536 ILE D Protein S 1 FT #SUB 102 536 ILE C 328 762 ILE D Protein S 1 FT #SUB 102 536 ILE C 380 814 GLN D Protein S 1 FT #SUB 103 537 PRO C 83 517 TYR D Protein S 1 FT #SUB 103 537 PRO C 88 522 VAL D Protein S 1 FT #SUB 103 537 PRO C 93 527 CYS D Protein S 1 FT #SUB 103 537 PRO C 98 532 GLY D Protein B 2 FT #SUB 104 538 VAL C 96 530 VAL D Protein B 3 FT #SUB 104 538 VAL C 97 531 ILE D Protein A 5 FT #SUB 104 538 VAL C 98 532 GLY D Protein A 6 FT #SUB 104 538 VAL C 99 533 TYR D Protein S 1 FT #SUB 104 538 VAL C 100 534 MET D Protein S 2 FT #SUB 105 539 GLY C 93 527 CYS D Protein B 2 FT #SUB 105 539 GLY C 94 528 GLU D Protein B 1 FT #SUB 105 539 GLY C 95 529 ASN D Protein B 3 FT #SUB 106 540 VAL C 65 499 LEU D Protein S 1 FT #SUB 106 540 VAL C 95 529 ASN D Protein A 7 FT #SUB 106 540 VAL C 97 531 ILE D Protein S 1 FT #SUB 118 552 GLN C 65 499 LEU D Protein S 4 FT #SUB 118 552 GLN C 68 502 LYS D Protein S 1 FT #SUB 118 552 GLN C 69 503 LEU D Protein S 2 FT #SUB 123 557 THR C 92 526 CYS D Protein B 1 FT #SUB 123 557 THR C 93 527 CYS D Protein B 1 FT #SUB 124 558 THR C 92 526 CYS D Protein B 12 FT #SUB 124 558 THR C 374 808 GLY D Protein S 3 FT #SUB 124 558 THR C 377 811 LEU D Protein S 1 FT #SUB 125 559 GLU C 92 526 CYS D Protein B 5 FT #SUB 125 559 GLU C 257 691 LYS D Protein S 3 FT #SUB 125 559 GLU C 333 767 ASP D Protein S 2 FT #SUB 126 560 GLY C 91 525 ALA D Protein B 3 FT #SUB 126 560 GLY C 92 526 CYS D Protein B 5 FT #SUB 126 560 GLY C 94 528 GLU D Protein B 2 FT #SUB 127 561 CYS C 94 528 GLU D Protein B 8 FT #SUB 128 562 LEU C 94 528 GLU D Protein B 1 FT #SUB 129 563 VAL C 93 527 CYS D Protein S 1 FT #SUB 129 563 VAL C 94 528 GLU D Protein A 7 FT #SUB 130 564 ALA C 94 528 GLU D Protein A 6 FT #SUB 133 567 ASN C 95 529 ASN D Protein S 3 FT #SUB 161 595 ARG C 296 730 GLU D Protein S 4 FT #SUB 161 595 ARG C 300 734 ASN D Protein S 1 FT #SUB 203 637 SER C 308 742 MET D Protein S 1 FT #SUB 204 638 ILE C 308 742 MET D Protein B 1 FT #SUB 205 639 ALA C 304 738 VAL D Protein S 1 FT #SUB 208 642 ASN C 300 734 ASN D Protein S 4 FT #SUB 210 644 TYR C 300 734 ASN D Protein S 5 FT #SUB 210 644 TYR C 304 738 VAL D Protein S 3 FT #SUB 210 644 TYR C 305 739 GLY D Protein S 5 FT #SUB 210 644 TYR C 308 742 MET D Protein S 1 FT #SUB 247 681 LEU C 296 730 GLU D Protein S 1 FT #SUB 247 681 LEU C 297 731 VAL D Protein A 2 FT #SUB 247 681 LEU C 300 734 ASN D Protein S 3 FT #SUB 247 681 LEU C 423 857 LEU D Protein B 1 FT #SUB 249 683 VAL C 423 857 LEU D Protein S 1 FT #SUB 250 684 SER C 301 735 LYS D Protein A 7 FT #SUB 250 684 SER C 423 857 LEU D Protein B 1 FT #SUB 251 685 GLY C 301 735 LYS D Protein B 4 FT #SUB 251 685 GLY C 305 739 GLY D Protein B 2 FT #SUB 252 686 ASN C 301 735 LYS D Protein A 14 FT #SUB 252 686 ASN C 302 736 ASN D Protein S 2 FT #SUB 252 686 ASN C 305 739 GLY D Protein B 1 FT #SUB 252 686 ASN C 306 740 SER D Protein S 4 FT #SUB 252 686 ASN C 309 743 ALA D Protein B 1 FT #SUB 252 686 ASN C 316 750 ASN D Protein S 4 FT #SUB 253 687 TYR C 308 742 MET D Protein S 2 FT #SUB 255 689 THR C 309 743 ALA D Protein S 1 FT #SUB 257 691 LYS C 125 559 GLU D Protein S 3 FT #SUB 257 691 LYS C 320 754 ALA D Protein B 1 FT #SUB 257 691 LYS C 321 755 ASN D Protein S 6 FT #SUB 258 692 LYS C 314 748 GLY D Protein S 4 FT #SUB 258 692 LYS C 316 750 ASN D Protein S 8 FT #SUB 258 692 LYS C 317 751 ALA D Protein S 5 FT #SUB 259 693 PRO C 311 745 SER D Protein B 4 FT #SUB 259 693 PRO C 312 746 ILE D Protein S 1 FT #SUB 260 694 ALA C 309 743 ALA D Protein A 3 FT #SUB 260 694 ALA C 310 744 GLY D Protein B 2 FT #SUB 261 695 ALA C 309 743 ALA D Protein A 4 FT #SUB 261 695 ALA C 310 744 GLY D Protein A 4 FT #SUB 262 696 ILE C 309 743 ALA D Protein A 5 FT #SUB 296 730 GLU C 161 595 ARG D Protein S 4 FT #SUB 296 730 GLU C 247 681 LEU D Protein B 1 FT #SUB 297 731 VAL C 247 681 LEU D Protein S 2 FT #SUB 300 734 ASN C 161 595 ARG D Protein S 1 FT #SUB 300 734 ASN C 208 642 ASN D Protein S 5 FT #SUB 300 734 ASN C 210 644 TYR D Protein B 5 FT #SUB 300 734 ASN C 247 681 LEU D Protein S 3 FT #SUB 301 735 LYS C 250 684 SER D Protein S 7 FT #SUB 301 735 LYS C 251 685 GLY D Protein A 4 FT #SUB 301 735 LYS C 252 686 ASN D Protein A 13 FT #SUB 302 736 ASN C 252 686 ASN D Protein A 3 FT #SUB 304 738 VAL C 205 639 ALA D Protein S 1 FT #SUB 304 738 VAL C 210 644 TYR D Protein A 4 FT #SUB 305 739 GLY C 210 644 TYR D Protein B 5 FT #SUB 305 739 GLY C 251 685 GLY D Protein B 2 FT #SUB 305 739 GLY C 252 686 ASN D Protein B 1 FT #SUB 306 740 SER C 252 686 ASN D Protein A 4 FT #SUB 308 742 MET C 204 638 ILE D Protein S 1 FT #SUB 308 742 MET C 210 644 TYR D Protein S 1 FT #SUB 308 742 MET C 253 687 TYR D Protein B 2 FT #SUB 309 743 ALA C 252 686 ASN D Protein S 1 FT #SUB 309 743 ALA C 255 689 THR D Protein S 1 FT #SUB 309 743 ALA C 260 694 ALA D Protein B 3 FT #SUB 309 743 ALA C 261 695 ALA D Protein B 4 FT #SUB 309 743 ALA C 262 696 ILE D Protein A 5 FT #SUB 310 744 GLY C 260 694 ALA D Protein B 2 FT #SUB 310 744 GLY C 261 695 ALA D Protein B 4 FT #SUB 311 745 SER C 259 693 PRO D Protein A 4 FT #SUB 312 746 ILE C 259 693 PRO D Protein B 1 FT #SUB 314 748 GLY C 258 692 LYS D Protein B 5 FT #SUB 316 750 ASN C 252 686 ASN D Protein B 4 FT #SUB 316 750 ASN C 258 692 LYS D Protein A 7 FT #SUB 317 751 ALA C 258 692 LYS D Protein B 4 FT #SUB 320 754 ALA C 257 691 LYS D Protein S 1 FT #SUB 320 754 ALA C 335 769 ALA D Protein A 3 FT #SUB 320 754 ALA C 338 772 VAL D Protein S 1 FT #SUB 321 755 ASN C 257 691 LYS D Protein S 6 FT #SUB 321 755 ASN C 335 769 ALA D Protein A 2 FT #SUB 324 758 THR C 334 768 ALA D Protein S 2 FT #SUB 324 758 THR C 335 769 ALA D Protein S 4 FT #SUB 328 762 ILE C 100 534 MET D Protein B 1 FT #SUB 328 762 ILE C 102 536 ILE D Protein S 1 FT #SUB 329 763 ALA C 100 534 MET D Protein B 2 FT #SUB 333 767 ASP C 125 559 GLU D Protein S 2 FT #SUB 334 768 ALA C 324 758 THR D Protein A 2 FT #SUB 334 768 ALA C 337 771 ASN D Protein B 2 FT #SUB 335 769 ALA C 320 754 ALA D Protein A 3 FT #SUB 335 769 ALA C 321 755 ASN D Protein S 2 FT #SUB 335 769 ALA C 324 758 THR D Protein A 4 FT #SUB 335 769 ALA C 337 771 ASN D Protein B 1 FT #SUB 337 771 ASN C 334 768 ALA D Protein S 2 FT #SUB 337 771 ASN C 335 769 ALA D Protein S 1 FT #SUB 337 771 ASN C 337 771 ASN D Protein S 9 FT #SUB 338 772 VAL C 320 754 ALA D Protein S 1 FT #SUB 338 772 VAL C 337 771 ASN D Protein S 1 FT #SUB 338 772 VAL C 341 775 SER D Protein S 1 FT #SUB 374 808 GLY C 124 558 THR D Protein B 4 FT #SUB 377 811 LEU C 124 558 THR D Protein S 1 FT #SUB 378 812 LEU C 77 511 TYR D Protein A 3 FT #SUB 379 813 PRO C 77 511 TYR D Protein A 4 FT #SUB 379 813 PRO C 100 534 MET D Protein A 4 FT #SUB 379 813 PRO C 101 535 PRO D Protein S 2 FT #SUB 380 814 GLN C 100 534 MET D Protein A 8 FT #SUB 380 814 GLN C 101 535 PRO D Protein S 1 FT #SUB 380 814 GLN C 102 536 ILE D Protein S 1 FT #SUB 382 816 ALA C 74 508 SER D Protein A 5 FT #SUB 382 816 ALA C 78 512 LEU D Protein S 2 FT #SUB 383 817 CYS C 78 512 LEU D Protein S 1 FT #SUB 383 817 CYS C 100 534 MET D Protein S 1 FT #SUB 385 819 GLN C 74 508 SER D Protein A 7 FT #SUB 386 820 MET C 65 499 LEU D Protein S 1 FT #SUB 386 820 MET C 69 503 LEU D Protein B 1 FT #SUB 386 820 MET C 74 508 SER D Protein B 4 FT #SUB 386 820 MET C 75 509 LEU D Protein S 2 FT #SUB 386 820 MET C 97 531 ILE D Protein S 2 FT #SUB 423 857 LEU C 247 681 LEU D Protein B 1 FT #SUB 423 857 LEU C 249 683 VAL D Protein S 1 FT #SUB 423 857 LEU C 250 684 SER D Protein S 1 FT #HET 125 559 GLU C 8 876 RIE D S 7 FT #HET 126 560 GLY C 8 876 RIE D B 1 FT #HET 127 561 CYS C 8 876 RIE D A 6 FT #HET 128 562 LEU C 8 876 RIE D B 2 FT #HET 130 564 ALA C 8 876 RIE D A 5 FT #HET 131 565 SER C 8 876 RIE D A 11 FT #HET 134 568 ARG C 8 876 RIE D S 2 FT #HET 156 590 ARG C 6 876 RIE C S 10 FT #HET 220 654 ALA C 5 3 SO4 C S 1 FT #HET 221 655 MET C 5 3 SO4 C A 4 FT #HET 222 656 GLY C 5 3 SO4 C B 6 FT #HET 223 657 MET C 5 3 SO4 C A 4 FT #HET 224 658 ASN C 5 3 SO4 C A 6 FT #HET 227 661 SER C 6 876 RIE C S 4 FT #HET 249 683 VAL C 6 876 RIE C S 3 FT #HET 250 684 SER C 6 876 RIE C S 6 FT #HET 252 686 ASN C 6 876 RIE C S 1 FT #HET 256 690 ASP C 6 876 RIE C S 7 FT #HET 257 691 LYS C 6 876 RIE C S 2 FT #HET 258 692 LYS C 6 876 RIE C S 3 FT #HET 301 735 LYS C 8 876 RIE D S 4 FT #HET 317 751 ALA C 8 876 RIE D B 3 FT #HET 318 752 HIS C 8 876 RIE D S 2 FT #HET 321 755 ASN C 8 876 RIE D S 4 FT #HET 419 853 LEU C 8 876 RIE D A 8 FT #HET 422 856 ALA C 8 876 RIE D S 5 FT #HET 423 857 LEU C 8 876 RIE D S 2 FT DISORDER 1 9 FT DISORDER 21 23 FT DISORDER 38 47 FT DISORDER 427 441 CC SEQUENCE 404 AA (ATOM); CC PNEECLQILG NGAKFLSDAE IIQLVETLIE THERGVSIRR QLLSKKLSEP SSLQYLPYRD CC YNYSLVMGAC CENVIGYMPI PVGVAGPLCL DEKEFQVPMA TTEGCLVAST NRGCRAIGLG CC GGASSRVLAD GMTRGPVVRL PRACDSAEVK AWLETSEGFA VIKEAFDSTS RFARLQKLHT CC SIAGRNLYIR FQSRSGDAMG MNMISKGTEK ALSKLHEYFP EMQILAVSGN YCTDKKPAAI CC NWIEGRGKSV VCEAVIPAKV VREVLKTTTE AMIEVNINKN LVGSAMAGSI GGYNAHAANI CC VTAIYIACGQ DAAQNVGSSN CITLMEASGP TNEDLYISCT MPSIEIGTVG GGTNLLPQQA CC CLQMLGVQGA CKDNPGENAR QLARIVCGTV MAGELSLMAA LAAG CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES HHHHHHEPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETL CC ATOM ---------PNEECLQILGN---GAKFLSDAEIIQLV----------ETL CC *********** ************** *** CC SEQRES IETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYM CC ATOM IETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYM CC ************************************************** CC SEQRES PIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVL CC ATOM PIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVL CC ************************************************** CC SEQRES ADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKL CC ATOM ADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKL CC ************************************************** CC SEQRES HTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVS CC ATOM HTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVS CC ************************************************** CC SEQRES GNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNIN CC ATOM GNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNIN CC ************************************************** CC SEQRES KNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEAS CC ATOM KNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEAS CC ************************************************** CC SEQRES GPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGEN CC ATOM GPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGEN CC ************************************************** CC SEQRES ARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKIN CC ATOM ARQLARIVCGTVMAGELSLMAALAAG--------------- CC ************************** SQ SEQUENCE 441 AA; MW; CN; HHHHHHEPRP NEECLQILGN AEKGAKFLSD AEIIQLVNAK HIPAYKLETL IETHERGVSI RRQLLSKKLS EPSSLQYLPY RDYNYSLVMG ACCENVIGYM PIPVGVAGPL CLDEKEFQVP MATTEGCLVA STNRGCRAIG LGGGASSRVL ADGMTRGPVV RLPRACDSAE VKAWLETSEG FAVIKEAFDS TSRFARLQKL HTSIAGRNLY IRFQSRSGDA MGMNMISKGT EKALSKLHEY FPEMQILAVS GNYCTDKKPA AINWIEGRGK SVVCEAVIPA KVVREVLKTT TEAMIEVNIN KNLVGSAMAG SIGGYNAHAA NIVTAIYIAC GQDAAQNVGS SNCITLMEAS GPTNEDLYIS CTMPSIEIGT VGGGTNLLPQ QACLQMLGVQ GACKDNPGEN ARQLARIVCG TVMAGELSLM AALAAGHLVK SHMIHNRSKI N // ID 2R4FD STANDARD; PRT; 441 AA. DT CONVERTED FROM PDB (SEQRES) 2R4F DE 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.700 CC R-Factor 0.215 FT #SUB 146 580 SER D 166 600 CYS A Protein S 1 FT #SUB 148 582 ARG D 166 600 CYS A Protein S 5 FT #SUB 148 582 ARG D 169 603 ALA A Protein S 1 FT #SUB 150 584 LEU D 169 603 ALA A Protein S 1 FT #SUB 150 584 LEU D 204 638 ILE A Protein S 3 FT #SUB 164 598 ARG D 275 709 GLU A Protein A 8 FT #SUB 164 598 ARG D 277 711 VAL A Protein S 2 FT #SUB 164 598 ARG D 358 792 TYR A Protein S 1 FT #SUB 165 599 ALA D 273 707 VAL A Protein S 1 FT #SUB 165 599 ALA D 275 709 GLU A Protein A 10 FT #SUB 165 599 ALA D 358 792 TYR A Protein A 2 FT #SUB 166 600 CYS D 146 580 SER A Protein S 1 FT #SUB 166 600 CYS D 148 582 ARG A Protein S 6 FT #SUB 166 600 CYS D 275 709 GLU A Protein A 4 FT #SUB 169 603 ALA D 148 582 ARG A Protein S 1 FT #SUB 169 603 ALA D 150 584 LEU A Protein S 1 FT #SUB 199 633 LYS D 199 633 LYS A Protein S 4 FT #SUB 201 635 HIS D 265 699 ILE A Protein S 3 FT #SUB 201 635 HIS D 266 700 GLU A Protein S 6 FT #SUB 203 637 SER D 265 699 ILE A Protein S 1 FT #SUB 204 638 ILE D 150 584 LEU A Protein S 3 FT #SUB 204 638 ILE D 362 796 THR A Protein B 1 FT #SUB 205 639 ALA D 346 780 LEU A Protein A 3 FT #SUB 205 639 ALA D 362 796 THR A Protein B 2 FT #SUB 206 640 GLY D 273 707 VAL A Protein B 2 FT #SUB 206 640 GLY D 360 794 SER A Protein B 2 FT #SUB 206 640 GLY D 362 796 THR A Protein B 2 FT #SUB 207 641 ARG D 348 782 GLU A Protein S 10 FT #SUB 207 641 ARG D 358 792 TYR A Protein A 2 FT #SUB 261 695 ALA D 261 695 ALA A Protein S 1 FT #SUB 261 695 ALA D 265 699 ILE A Protein A 2 FT #SUB 262 696 ILE D 265 699 ILE A Protein A 3 FT #SUB 265 699 ILE D 201 635 HIS A Protein A 4 FT #SUB 265 699 ILE D 203 637 SER A Protein B 1 FT #SUB 265 699 ILE D 261 695 ALA A Protein S 2 FT #SUB 265 699 ILE D 262 696 ILE A Protein S 4 FT #SUB 266 700 GLU D 201 635 HIS A Protein S 2 FT #SUB 266 700 GLU D 266 700 GLU A Protein S 5 FT #SUB 273 707 VAL D 165 599 ALA A Protein S 1 FT #SUB 273 707 VAL D 204 638 ILE A Protein S 1 FT #SUB 273 707 VAL D 206 640 GLY A Protein S 2 FT #SUB 275 709 GLU D 164 598 ARG A Protein S 6 FT #SUB 275 709 GLU D 165 599 ALA A Protein S 10 FT #SUB 275 709 GLU D 166 600 CYS A Protein S 5 FT #SUB 346 780 LEU D 205 639 ALA A Protein S 3 FT #SUB 348 782 GLU D 207 641 ARG A Protein S 10 FT #SUB 358 792 TYR D 165 599 ALA A Protein S 2 FT #SUB 358 792 TYR D 207 641 ARG A Protein S 2 FT #SUB 360 794 SER D 206 640 GLY A Protein S 2 FT #SUB 362 796 THR D 204 638 ILE A Protein S 1 FT #SUB 362 796 THR D 205 639 ALA A Protein S 2 FT #SUB 362 796 THR D 206 640 GLY A Protein S 2 FT #SUB 264 698 TRP D 307 741 ALA B Protein S 4 FT #SUB 264 698 TRP D 308 742 MET B Protein S 5 FT #SUB 265 699 ILE D 308 742 MET B Protein S 1 FT #SUB 265 699 ILE D 309 743 ALA B Protein S 1 FT #SUB 299 733 ILE D 299 733 ILE B Protein S 1 FT #SUB 303 737 LEU D 304 738 VAL B Protein S 1 FT #SUB 304 738 VAL D 303 737 LEU B Protein S 1 FT #SUB 304 738 VAL D 344 778 ILE B Protein S 1 FT #SUB 304 738 VAL D 346 780 LEU B Protein S 1 FT #SUB 307 741 ALA D 264 698 TRP B Protein B 4 FT #SUB 307 741 ALA D 315 749 TYR B Protein A 6 FT #SUB 308 742 MET D 264 698 TRP B Protein A 6 FT #SUB 308 742 MET D 265 699 ILE B Protein B 1 FT #SUB 309 743 ALA D 265 699 ILE B Protein B 1 FT #SUB 310 744 GLY D 312 746 ILE B Protein B 3 FT #SUB 312 746 ILE D 310 744 GLY B Protein S 3 FT #SUB 312 746 ILE D 312 746 ILE B Protein S 3 FT #SUB 315 749 TYR D 307 741 ALA B Protein S 6 FT #SUB 315 749 TYR D 315 749 TYR B Protein S 4 FT #SUB 344 778 ILE D 304 738 VAL B Protein S 1 FT #SUB 346 780 LEU D 304 738 VAL B Protein S 1 FT #SUB 65 499 LEU D 106 540 VAL C Protein S 1 FT #SUB 65 499 LEU D 118 552 GLN C Protein S 4 FT #SUB 65 499 LEU D 386 820 MET C Protein S 1 FT #SUB 68 502 LYS D 118 552 GLN C Protein S 1 FT #SUB 69 503 LEU D 118 552 GLN C Protein S 2 FT #SUB 69 503 LEU D 386 820 MET C Protein S 1 FT #SUB 74 508 SER D 382 816 ALA C Protein A 5 FT #SUB 74 508 SER D 385 819 GLN C Protein A 7 FT #SUB 74 508 SER D 386 820 MET C Protein S 4 FT #SUB 75 509 LEU D 386 820 MET C Protein S 2 FT #SUB 77 511 TYR D 378 812 LEU C Protein S 3 FT #SUB 77 511 TYR D 379 813 PRO C Protein B 4 FT #SUB 78 512 LEU D 382 816 ALA C Protein A 2 FT #SUB 78 512 LEU D 383 817 CYS C Protein S 1 FT #SUB 83 517 TYR D 101 535 PRO C Protein S 1 FT #SUB 83 517 TYR D 103 537 PRO C Protein S 1 FT #SUB 88 522 VAL D 103 537 PRO C Protein S 1 FT #SUB 91 525 ALA D 126 560 GLY C Protein B 3 FT #SUB 92 526 CYS D 123 557 THR C Protein B 1 FT #SUB 92 526 CYS D 124 558 THR C Protein A 12 FT #SUB 92 526 CYS D 125 559 GLU C Protein B 5 FT #SUB 92 526 CYS D 126 560 GLY C Protein B 5 FT #SUB 93 527 CYS D 103 537 PRO C Protein S 1 FT #SUB 93 527 CYS D 105 539 GLY C Protein S 2 FT #SUB 93 527 CYS D 123 557 THR C Protein S 1 FT #SUB 93 527 CYS D 129 563 VAL C Protein S 1 FT #SUB 94 528 GLU D 105 539 GLY C Protein B 1 FT #SUB 94 528 GLU D 126 560 GLY C Protein S 2 FT #SUB 94 528 GLU D 127 561 CYS C Protein S 8 FT #SUB 94 528 GLU D 128 562 LEU C Protein S 1 FT #SUB 94 528 GLU D 129 563 VAL C Protein A 7 FT #SUB 94 528 GLU D 130 564 ALA C Protein S 6 FT #SUB 95 529 ASN D 105 539 GLY C Protein B 3 FT #SUB 95 529 ASN D 106 540 VAL C Protein A 7 FT #SUB 95 529 ASN D 133 567 ASN C Protein S 3 FT #SUB 96 530 VAL D 104 538 VAL C Protein A 3 FT #SUB 97 531 ILE D 104 538 VAL C Protein A 5 FT #SUB 97 531 ILE D 106 540 VAL C Protein S 1 FT #SUB 97 531 ILE D 386 820 MET C Protein S 2 FT #SUB 98 532 GLY D 103 537 PRO C Protein B 2 FT #SUB 98 532 GLY D 104 538 VAL C Protein B 6 FT #SUB 99 533 TYR D 99 533 TYR C Protein S 2 FT #SUB 99 533 TYR D 101 535 PRO C Protein S 1 FT #SUB 99 533 TYR D 102 536 ILE C Protein A 3 FT #SUB 99 533 TYR D 104 538 VAL C Protein B 1 FT #SUB 100 534 MET D 100 534 MET C Protein B 2 FT #SUB 100 534 MET D 101 535 PRO C Protein B 2 FT #SUB 100 534 MET D 102 536 ILE C Protein A 11 FT #SUB 100 534 MET D 104 538 VAL C Protein A 2 FT #SUB 100 534 MET D 328 762 ILE C Protein S 1 FT #SUB 100 534 MET D 329 763 ALA C Protein S 2 FT #SUB 100 534 MET D 379 813 PRO C Protein S 4 FT #SUB 100 534 MET D 380 814 GLN C Protein S 8 FT #SUB 100 534 MET D 383 817 CYS C Protein S 1 FT #SUB 101 535 PRO D 83 517 TYR C Protein S 2 FT #SUB 101 535 PRO D 99 533 TYR C Protein S 2 FT #SUB 101 535 PRO D 100 534 MET C Protein B 2 FT #SUB 101 535 PRO D 379 813 PRO C Protein S 2 FT #SUB 101 535 PRO D 380 814 GLN C Protein B 1 FT #SUB 102 536 ILE D 99 533 TYR C Protein B 3 FT #SUB 102 536 ILE D 100 534 MET C Protein A 11 FT #SUB 102 536 ILE D 102 536 ILE C Protein S 1 FT #SUB 102 536 ILE D 328 762 ILE C Protein S 1 FT #SUB 102 536 ILE D 380 814 GLN C Protein S 1 FT #SUB 103 537 PRO D 83 517 TYR C Protein S 1 FT #SUB 103 537 PRO D 88 522 VAL C Protein S 3 FT #SUB 103 537 PRO D 93 527 CYS C Protein S 1 FT #SUB 103 537 PRO D 98 532 GLY C Protein B 2 FT #SUB 104 538 VAL D 96 530 VAL C Protein B 3 FT #SUB 104 538 VAL D 97 531 ILE C Protein A 4 FT #SUB 104 538 VAL D 98 532 GLY C Protein A 6 FT #SUB 104 538 VAL D 99 533 TYR C Protein S 1 FT #SUB 104 538 VAL D 100 534 MET C Protein S 2 FT #SUB 105 539 GLY D 93 527 CYS C Protein B 2 FT #SUB 105 539 GLY D 94 528 GLU C Protein B 1 FT #SUB 105 539 GLY D 95 529 ASN C Protein B 3 FT #SUB 106 540 VAL D 65 499 LEU C Protein S 1 FT #SUB 106 540 VAL D 95 529 ASN C Protein A 8 FT #SUB 106 540 VAL D 97 531 ILE C Protein S 1 FT #SUB 118 552 GLN D 65 499 LEU C Protein S 4 FT #SUB 118 552 GLN D 68 502 LYS C Protein S 1 FT #SUB 118 552 GLN D 69 503 LEU C Protein S 1 FT #SUB 123 557 THR D 92 526 CYS C Protein B 1 FT #SUB 123 557 THR D 93 527 CYS C Protein B 1 FT #SUB 124 558 THR D 92 526 CYS C Protein B 11 FT #SUB 124 558 THR D 374 808 GLY C Protein S 4 FT #SUB 124 558 THR D 377 811 LEU C Protein S 1 FT #SUB 125 559 GLU D 92 526 CYS C Protein B 5 FT #SUB 125 559 GLU D 257 691 LYS C Protein S 3 FT #SUB 125 559 GLU D 333 767 ASP C Protein S 2 FT #SUB 126 560 GLY D 91 525 ALA C Protein B 2 FT #SUB 126 560 GLY D 92 526 CYS C Protein B 5 FT #SUB 126 560 GLY D 94 528 GLU C Protein B 2 FT #SUB 127 561 CYS D 94 528 GLU C Protein B 8 FT #SUB 128 562 LEU D 94 528 GLU C Protein B 1 FT #SUB 129 563 VAL D 93 527 CYS C Protein S 1 FT #SUB 129 563 VAL D 94 528 GLU C Protein A 6 FT #SUB 130 564 ALA D 94 528 GLU C Protein A 6 FT #SUB 133 567 ASN D 95 529 ASN C Protein S 2 FT #SUB 161 595 ARG D 296 730 GLU C Protein S 4 FT #SUB 161 595 ARG D 300 734 ASN C Protein S 1 FT #SUB 204 638 ILE D 308 742 MET C Protein B 1 FT #SUB 205 639 ALA D 304 738 VAL C Protein S 1 FT #SUB 208 642 ASN D 300 734 ASN C Protein S 5 FT #SUB 210 644 TYR D 300 734 ASN C Protein S 5 FT #SUB 210 644 TYR D 304 738 VAL C Protein S 4 FT #SUB 210 644 TYR D 305 739 GLY C Protein S 5 FT #SUB 210 644 TYR D 308 742 MET C Protein S 1 FT #SUB 247 681 LEU D 296 730 GLU C Protein S 1 FT #SUB 247 681 LEU D 297 731 VAL C Protein A 2 FT #SUB 247 681 LEU D 300 734 ASN C Protein S 3 FT #SUB 247 681 LEU D 423 857 LEU C Protein B 1 FT #SUB 249 683 VAL D 423 857 LEU C Protein S 1 FT #SUB 250 684 SER D 301 735 LYS C Protein A 7 FT #SUB 250 684 SER D 423 857 LEU C Protein B 1 FT #SUB 251 685 GLY D 301 735 LYS C Protein B 4 FT #SUB 251 685 GLY D 305 739 GLY C Protein B 2 FT #SUB 252 686 ASN D 301 735 LYS C Protein A 13 FT #SUB 252 686 ASN D 302 736 ASN C Protein S 3 FT #SUB 252 686 ASN D 305 739 GLY C Protein B 1 FT #SUB 252 686 ASN D 306 740 SER C Protein S 4 FT #SUB 252 686 ASN D 309 743 ALA C Protein B 1 FT #SUB 252 686 ASN D 316 750 ASN C Protein S 4 FT #SUB 253 687 TYR D 308 742 MET C Protein S 2 FT #SUB 255 689 THR D 309 743 ALA C Protein S 1 FT #SUB 257 691 LYS D 125 559 GLU C Protein S 3 FT #SUB 257 691 LYS D 320 754 ALA C Protein B 1 FT #SUB 257 691 LYS D 321 755 ASN C Protein S 6 FT #SUB 258 692 LYS D 314 748 GLY C Protein S 5 FT #SUB 258 692 LYS D 316 750 ASN C Protein S 7 FT #SUB 258 692 LYS D 317 751 ALA C Protein S 4 FT #SUB 259 693 PRO D 311 745 SER C Protein B 4 FT #SUB 259 693 PRO D 312 746 ILE C Protein S 1 FT #SUB 260 694 ALA D 309 743 ALA C Protein A 3 FT #SUB 260 694 ALA D 310 744 GLY C Protein B 2 FT #SUB 261 695 ALA D 309 743 ALA C Protein A 4 FT #SUB 261 695 ALA D 310 744 GLY C Protein A 4 FT #SUB 262 696 ILE D 309 743 ALA C Protein A 5 FT #SUB 296 730 GLU D 161 595 ARG C Protein S 4 FT #SUB 296 730 GLU D 247 681 LEU C Protein B 1 FT #SUB 297 731 VAL D 247 681 LEU C Protein S 2 FT #SUB 300 734 ASN D 161 595 ARG C Protein S 1 FT #SUB 300 734 ASN D 208 642 ASN C Protein S 4 FT #SUB 300 734 ASN D 210 644 TYR C Protein B 5 FT #SUB 300 734 ASN D 247 681 LEU C Protein S 3 FT #SUB 301 735 LYS D 250 684 SER C Protein S 7 FT #SUB 301 735 LYS D 251 685 GLY C Protein A 4 FT #SUB 301 735 LYS D 252 686 ASN C Protein A 14 FT #SUB 302 736 ASN D 252 686 ASN C Protein A 2 FT #SUB 304 738 VAL D 205 639 ALA C Protein S 1 FT #SUB 304 738 VAL D 210 644 TYR C Protein A 3 FT #SUB 305 739 GLY D 210 644 TYR C Protein B 5 FT #SUB 305 739 GLY D 251 685 GLY C Protein B 2 FT #SUB 305 739 GLY D 252 686 ASN C Protein B 1 FT #SUB 306 740 SER D 252 686 ASN C Protein A 4 FT #SUB 308 742 MET D 203 637 SER C Protein S 1 FT #SUB 308 742 MET D 204 638 ILE C Protein S 1 FT #SUB 308 742 MET D 210 644 TYR C Protein S 1 FT #SUB 308 742 MET D 253 687 TYR C Protein B 2 FT #SUB 309 743 ALA D 252 686 ASN C Protein S 1 FT #SUB 309 743 ALA D 255 689 THR C Protein S 1 FT #SUB 309 743 ALA D 260 694 ALA C Protein B 3 FT #SUB 309 743 ALA D 261 695 ALA C Protein B 4 FT #SUB 309 743 ALA D 262 696 ILE C Protein A 5 FT #SUB 310 744 GLY D 260 694 ALA C Protein B 2 FT #SUB 310 744 GLY D 261 695 ALA C Protein B 4 FT #SUB 311 745 SER D 259 693 PRO C Protein A 4 FT #SUB 312 746 ILE D 259 693 PRO C Protein B 1 FT #SUB 314 748 GLY D 258 692 LYS C Protein B 4 FT #SUB 316 750 ASN D 252 686 ASN C Protein B 4 FT #SUB 316 750 ASN D 258 692 LYS C Protein A 8 FT #SUB 317 751 ALA D 258 692 LYS C Protein B 5 FT #SUB 320 754 ALA D 257 691 LYS C Protein S 1 FT #SUB 320 754 ALA D 335 769 ALA C Protein A 3 FT #SUB 320 754 ALA D 338 772 VAL C Protein S 1 FT #SUB 321 755 ASN D 257 691 LYS C Protein S 6 FT #SUB 321 755 ASN D 335 769 ALA C Protein A 2 FT #SUB 324 758 THR D 334 768 ALA C Protein S 2 FT #SUB 324 758 THR D 335 769 ALA C Protein S 4 FT #SUB 328 762 ILE D 100 534 MET C Protein B 1 FT #SUB 328 762 ILE D 102 536 ILE C Protein S 1 FT #SUB 329 763 ALA D 100 534 MET C Protein B 2 FT #SUB 333 767 ASP D 125 559 GLU C Protein S 2 FT #SUB 334 768 ALA D 324 758 THR C Protein A 2 FT #SUB 334 768 ALA D 337 771 ASN C Protein B 2 FT #SUB 335 769 ALA D 320 754 ALA C Protein A 3 FT #SUB 335 769 ALA D 321 755 ASN C Protein S 2 FT #SUB 335 769 ALA D 324 758 THR C Protein A 4 FT #SUB 335 769 ALA D 337 771 ASN C Protein B 1 FT #SUB 337 771 ASN D 334 768 ALA C Protein S 2 FT #SUB 337 771 ASN D 335 769 ALA C Protein S 1 FT #SUB 337 771 ASN D 337 771 ASN C Protein S 9 FT #SUB 337 771 ASN D 338 772 VAL C Protein B 1 FT #SUB 338 772 VAL D 320 754 ALA C Protein S 1 FT #SUB 341 775 SER D 338 772 VAL C Protein S 1 FT #SUB 374 808 GLY D 124 558 THR C Protein B 3 FT #SUB 377 811 LEU D 124 558 THR C Protein S 1 FT #SUB 378 812 LEU D 77 511 TYR C Protein A 6 FT #SUB 379 813 PRO D 77 511 TYR C Protein A 4 FT #SUB 379 813 PRO D 100 534 MET C Protein A 4 FT #SUB 379 813 PRO D 101 535 PRO C Protein S 1 FT #SUB 380 814 GLN D 100 534 MET C Protein A 8 FT #SUB 380 814 GLN D 101 535 PRO C Protein S 1 FT #SUB 380 814 GLN D 102 536 ILE C Protein S 1 FT #SUB 382 816 ALA D 74 508 SER C Protein A 5 FT #SUB 382 816 ALA D 78 512 LEU C Protein S 2 FT #SUB 383 817 CYS D 78 512 LEU C Protein S 1 FT #SUB 383 817 CYS D 100 534 MET C Protein S 1 FT #SUB 385 819 GLN D 74 508 SER C Protein A 7 FT #SUB 386 820 MET D 65 499 LEU C Protein S 1 FT #SUB 386 820 MET D 69 503 LEU C Protein B 1 FT #SUB 386 820 MET D 74 508 SER C Protein B 3 FT #SUB 386 820 MET D 75 509 LEU C Protein S 1 FT #SUB 386 820 MET D 97 531 ILE C Protein S 2 FT #SUB 423 857 LEU D 247 681 LEU C Protein B 1 FT #SUB 423 857 LEU D 249 683 VAL C Protein S 1 FT #SUB 423 857 LEU D 250 684 SER C Protein S 1 FT #HET 125 559 GLU D 6 876 RIE C S 7 FT #HET 126 560 GLY D 6 876 RIE C B 1 FT #HET 127 561 CYS D 6 876 RIE C A 7 FT #HET 128 562 LEU D 6 876 RIE C B 2 FT #HET 130 564 ALA D 6 876 RIE C A 5 FT #HET 131 565 SER D 6 876 RIE C A 12 FT #HET 134 568 ARG D 6 876 RIE C S 2 FT #HET 156 590 ARG D 8 876 RIE D S 10 FT #HET 220 654 ALA D 7 4 SO4 D S 1 FT #HET 221 655 MET D 7 4 SO4 D A 4 FT #HET 222 656 GLY D 7 4 SO4 D B 6 FT #HET 223 657 MET D 7 4 SO4 D A 5 FT #HET 224 658 ASN D 7 4 SO4 D A 7 FT #HET 227 661 SER D 8 876 RIE D S 4 FT #HET 249 683 VAL D 8 876 RIE D S 3 FT #HET 250 684 SER D 8 876 RIE D S 6 FT #HET 252 686 ASN D 8 876 RIE D S 1 FT #HET 256 690 ASP D 8 876 RIE D S 5 FT #HET 257 691 LYS D 8 876 RIE D S 2 FT #HET 258 692 LYS D 8 876 RIE D S 3 FT #HET 301 735 LYS D 6 876 RIE C S 4 FT #HET 317 751 ALA D 6 876 RIE C B 3 FT #HET 318 752 HIS D 6 876 RIE C S 2 FT #HET 321 755 ASN D 6 876 RIE C S 4 FT #HET 419 853 LEU D 6 876 RIE C S 8 FT #HET 422 856 ALA D 6 876 RIE C S 5 FT DISORDER 1 23 FT DISORDER 39 47 FT DISORDER 427 441 CC SEQUENCE 394 AA (ATOM); CC GAKFLSDAEI IQLVNETLIE THERGVSIRR QLLSKKLSEP SSLQYLPYRD YNYSLVMGAC CC CENVIGYMPI PVGVAGPLCL DEKEFQVPMA TTEGCLVAST NRGCRAIGLG GGASSRVLAD CC GMTRGPVVRL PRACDSAEVK AWLETSEGFA VIKEAFDSTS RFARLQKLHT SIAGRNLYIR CC FQSRSGDAMG MNMISKGTEK ALSKLHEYFP EMQILAVSGN YCTDKKPAAI NWIEGRGKSV CC VCEAVIPAKV VREVLKTTTE AMIEVNINKN LVGSAMAGSI GGYNAHAANI VTAIYIACGQ CC DAAQNVGSSN CITLMEASGP TNEDLYISCT MPSIEIGTVG GGTNLLPQQA CLQMLGVQGA CC CKDNPGENAR QLARIVCGTV MAGELSLMAA LAAG CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES HHHHHHEPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETL CC ATOM -----------------------GAKFLSDAEIIQLVN---------ETL CC *************** *** CC SEQRES IETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYM CC ATOM IETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYM CC ************************************************** CC SEQRES PIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVL CC ATOM PIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVL CC ************************************************** CC SEQRES ADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKL CC ATOM ADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKL CC ************************************************** CC SEQRES HTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVS CC ATOM HTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVS CC ************************************************** CC SEQRES GNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNIN CC ATOM GNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNIN CC ************************************************** CC SEQRES KNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEAS CC ATOM KNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEAS CC ************************************************** CC SEQRES GPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGEN CC ATOM GPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGEN CC ************************************************** CC SEQRES ARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKIN CC ATOM ARQLARIVCGTVMAGELSLMAALAAG--------------- CC ************************** SQ SEQUENCE 441 AA; MW; CN; HHHHHHEPRP NEECLQILGN AEKGAKFLSD AEIIQLVNAK HIPAYKLETL IETHERGVSI RRQLLSKKLS EPSSLQYLPY RDYNYSLVMG ACCENVIGYM PIPVGVAGPL CLDEKEFQVP MATTEGCLVA STNRGCRAIG LGGGASSRVL ADGMTRGPVV RLPRACDSAE VKAWLETSEG FAVIKEAFDS TSRFARLQKL HTSIAGRNLY IRFQSRSGDA MGMNMISKGT EKALSKLHEY FPEMQILAVS GNYCTDKKPA AINWIEGRGK SVVCEAVIPA KVVREVLKTT TEAMIEVNIN KNLVGSAMAG SIGGYNAHAA NIVTAIYIAC GQDAAQNVGS SNCITLMEAS GPTNEDLYIS CTMPSIEIGT VGGGTNLLPQ QACLQMLGVQ GACKDNPGEN ARQLARIVCG TVMAGELSLM AALAAGHLVK SHMIHNRSKI N //