ID	2NNHA	STANDARD;	PRT;	476	AA.
DT	CONVERTED FROM PDB (SEQRES) 2NNH
DE	Cytochrome P450 2C8
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.600
CC	R-Factor	0.244
FT	#SUB	194	 212 	TRP	A	207	 225 	CYS	B	Protein	S	5
FT	#SUB	194	 212 	TRP	A	208	 226 	PHE	B	Protein	S	5
FT	#SUB	207	 225 	CYS	A	194	 212 	TRP	B	Protein	A	5
FT	#SUB	208	 226 	PHE	A	194	 212 	TRP	B	Protein	S	5
FT	#SUB	208	 226 	PHE	A	208	 226 	PHE	B	Protein	S	1
FT	#SUB	209	 227 	PRO	A	456	 474 	LYS	B	Protein	S	3
FT	#SUB	456	 474 	LYS	A	209	 227 	PRO	B	Protein	S	4
FT	#HET	79	  97 	ARG	A	2	500 	HEM	A	S	9
FT	#HET	79	  97 	ARG	A	3	501 	9CR	A	A	3
FT	#HET	80	  98 	GLY	A	3	501 	9CR	A	B	9
FT	#HET	81	  99 	ASN	A	3	501 	9CR	A	B	5
FT	#HET	82	 100 	SER	A	3	501 	9CR	A	A	3
FT	#HET	82	 100 	SER	A	4	502 	9CR	A	S	2
FT	#HET	84	 102 	ILE	A	4	502 	9CR	A	S	2
FT	#HET	84	 102 	ILE	A	10	503 	PLM	B	S	4
FT	#HET	85	 103 	SER	A	3	501 	9CR	A	S	2
FT	#HET	85	 103 	SER	A	4	502 	9CR	A	A	2
FT	#HET	87	 105 	ARG	A	10	503 	PLM	B	S	2
FT	#HET	88	 106 	ILE	A	4	502 	9CR	A	S	1
FT	#HET	88	 106 	ILE	A	10	503 	PLM	B	S	2
FT	#HET	94	 112 	ILE	A	2	500 	HEM	A	A	4
FT	#HET	95	 113 	ILE	A	2	500 	HEM	A	A	3
FT	#HET	95	 113 	ILE	A	3	501 	9CR	A	S	6
FT	#HET	96	 114 	SER	A	3	501 	9CR	A	S	1
FT	#HET	102	 120 	TRP	A	2	500 	HEM	A	S	5
FT	#HET	106	 124 	ARG	A	2	500 	HEM	A	S	3
FT	#HET	114	 132 	ARG	A	1	505 	SO4	A	A	7
FT	#HET	115	 133 	ASN	A	1	505 	SO4	A	A	3
FT	#HET	160	 178 	ILE	A	2	500 	HEM	A	S	1
FT	#HET	186	 204 	ASN	A	4	502 	9CR	A	S	1
FT	#HET	187	 205 	PHE	A	4	502 	9CR	A	S	1
FT	#HET	190	 208 	LEU	A	4	502 	9CR	A	A	9
FT	#HET	191	 209 	ASN	A	4	502 	9CR	A	S	1
FT	#HET	194	 212 	TRP	A	10	503 	PLM	B	S	5
FT	#HET	198	 216 	CYS	A	10	503 	PLM	B	S	2
FT	#HET	199	 217 	ASN	A	4	502 	9CR	A	S	3
FT	#HET	208	 226 	PHE	A	5	503 	PLM	A	A	10
FT	#HET	208	 226 	PHE	A	10	503 	PLM	B	S	3
FT	#HET	209	 227 	PRO	A	5	503 	PLM	A	A	8
FT	#HET	210	 228 	GLY	A	5	503 	PLM	A	B	7
FT	#HET	211	 229 	THR	A	5	503 	PLM	A	A	8
FT	#HET	211	 229 	THR	A	10	503 	PLM	B	S	2
FT	#HET	212	 230 	HIS	A	10	503 	PLM	B	S	2
FT	#HET	216	 234 	LEU	A	10	503 	PLM	B	S	1
FT	#HET	219	 237 	VAL	A	4	502 	9CR	A	S	1
FT	#HET	223	 241 	ARG	A	4	502 	9CR	A	S	4
FT	#HET	278	 296 	VAL	A	3	501 	9CR	A	B	1
FT	#HET	278	 296 	VAL	A	4	502 	9CR	A	S	7
FT	#HET	279	 297 	ALA	A	2	500 	HEM	A	A	14
FT	#HET	279	 297 	ALA	A	3	501 	9CR	A	S	1
FT	#HET	280	 298 	GLY	A	2	500 	HEM	A	B	5
FT	#HET	283	 301 	THR	A	2	500 	HEM	A	A	7
FT	#HET	283	 301 	THR	A	3	501 	9CR	A	S	2
FT	#HET	284	 302 	THR	A	2	500 	HEM	A	A	7
FT	#HET	287	 305 	THR	A	2	500 	HEM	A	S	1
FT	#HET	338	 356 	GLN	A	2	500 	HEM	A	S	1
FT	#HET	343	 361 	LEU	A	2	500 	HEM	A	S	1
FT	#HET	348	 366 	VAL	A	2	500 	HEM	A	S	1
FT	#HET	348	 366 	VAL	A	3	501 	9CR	A	S	2
FT	#HET	349	 367 	PRO	A	3	501 	9CR	A	A	3
FT	#HET	350	 368 	HIS	A	2	500 	HEM	A	S	6
FT	#HET	409	 427 	PRO	A	2	500 	HEM	A	B	3
FT	#HET	410	 428 	PHE	A	2	500 	HEM	A	A	8
FT	#HET	411	 429 	SER	A	2	500 	HEM	A	S	6
FT	#HET	415	 433 	ARG	A	2	500 	HEM	A	A	16
FT	#HET	417	 435 	CYS	A	2	500 	HEM	A	A	25
FT	#HET	418	 436 	ALA	A	2	500 	HEM	A	A	4
FT	#HET	419	 437 	GLY	A	2	500 	HEM	A	B	3
FT	#HET	422	 440 	LEU	A	2	500 	HEM	A	S	1
FT	#HET	423	 441 	ALA	A	2	500 	HEM	A	S	3
FT	#HET	458	 476 	ILE	A	3	501 	9CR	A	S	1
FT	#HET	458	 476 	ILE	A	4	502 	9CR	A	S	1
FT	DISORDER	1	9
FT	DISORDER	473	476
CC	SEQUENCE	463 AA (ATOM);
CC	KLPPGPTPLP IIGNMLQIDV KDICKSFTNF SKVYGPVFTV YFGMNPIVVF HGYEAVKEAL
CC	IDNGEEFSGR GNSPISQRIT KGLGIISSNG KRWKEIRRFS LTTLRNFGMG KRSIEDRVQE
CC	EAHCLVEELR KTKASPCDPT FILGCAPCNV ICSVVFQKRF DYKDQNFLTL MKRFNENFRI
CC	LNSPWIQVCN NFPLLIDCFP GTHNKVLKNV ALTRSYIREK VKEHQASLDV NNPRDFIDCF
CC	LIKMEQEKDN QKSEFNIENL VGTVADLFVA GTETTSTTLR YGLLLLLKHP EVTAKVQEEI
CC	DHVIGRHRSP CMQDRSHMPY TDAVVHEIQR YSDLVPTGVP HAVTTDTKFR NYLIPKGTTI
CC	MALLTSVLHD DKEFPNPNIF DPGHFLDKNG NFKKSDYFMP FSAGKRICAG EGLARMELFL
CC	FLTTILQNFN LKSVDDLKNL NTTAVTKGIV SLPPSYQICF IPV
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MAKKTSSKGKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVY
CC	ATOM   ---------KLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVY
CC	                *****************************************
CC	SEQRES FGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGK
CC	ATOM   FGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGK
CC	       **************************************************
CC	SEQRES RWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTF
CC	ATOM   RWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTF
CC	       **************************************************
CC	SEQRES ILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNN
CC	ATOM   ILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNN
CC	       **************************************************
CC	SEQRES FPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFL
CC	ATOM   FPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFL
CC	       **************************************************
CC	SEQRES IKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPE
CC	ATOM   IKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPE
CC	       **************************************************
CC	SEQRES VTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPH
CC	ATOM   VTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPH
CC	       **************************************************
CC	SEQRES AVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGN
CC	ATOM   AVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGN
CC	       **************************************************
CC	SEQRES FKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLN
CC	ATOM   FKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLN
CC	       **************************************************
CC	SEQRES TTAVTKGIVSLPPSYQICFIPVHHHH
CC	ATOM   TTAVTKGIVSLPPSYQICFIPV----
CC	       **********************    
SQ	SEQUENCE	476 AA;      MW;         CN;
	MAKKTSSKGK LPPGPTPLPI IGNMLQIDVK DICKSFTNFS KVYGPVFTVY FGMNPIVVFH
	GYEAVKEALI DNGEEFSGRG NSPISQRITK GLGIISSNGK RWKEIRRFSL TTLRNFGMGK
	RSIEDRVQEE AHCLVEELRK TKASPCDPTF ILGCAPCNVI CSVVFQKRFD YKDQNFLTLM
	KRFNENFRIL NSPWIQVCNN FPLLIDCFPG THNKVLKNVA LTRSYIREKV KEHQASLDVN
	NPRDFIDCFL IKMEQEKDNQ KSEFNIENLV GTVADLFVAG TETTSTTLRY GLLLLLKHPE
	VTAKVQEEID HVIGRHRSPC MQDRSHMPYT DAVVHEIQRY SDLVPTGVPH AVTTDTKFRN
	YLIPKGTTIM ALLTSVLHDD KEFPNPNIFD PGHFLDKNGN FKKSDYFMPF SAGKRICAGE
	GLARMELFLF LTTILQNFNL KSVDDLKNLN TTAVTKGIVS LPPSYQICFI PVHHHH
//
ID	2NNHB	STANDARD;	PRT;	476	AA.
DT	CONVERTED FROM PDB (SEQRES) 2NNH
DE	Cytochrome P450 2C8
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.600
CC	R-Factor	0.244
FT	#SUB	194	 212 	TRP	B	207	 225 	CYS	A	Protein	S	5
FT	#SUB	194	 212 	TRP	B	208	 226 	PHE	A	Protein	S	5
FT	#SUB	207	 225 	CYS	B	194	 212 	TRP	A	Protein	A	5
FT	#SUB	208	 226 	PHE	B	194	 212 	TRP	A	Protein	S	5
FT	#SUB	208	 226 	PHE	B	208	 226 	PHE	A	Protein	S	1
FT	#SUB	209	 227 	PRO	B	456	 474 	LYS	A	Protein	S	4
FT	#SUB	456	 474 	LYS	B	209	 227 	PRO	A	Protein	S	3
FT	#HET	79	  97 	ARG	B	7	500 	HEM	B	S	7
FT	#HET	79	  97 	ARG	B	8	501 	9CR	B	A	5
FT	#HET	80	  98 	GLY	B	8	501 	9CR	B	B	8
FT	#HET	81	  99 	ASN	B	8	501 	9CR	B	B	3
FT	#HET	82	 100 	SER	B	8	501 	9CR	B	A	2
FT	#HET	82	 100 	SER	B	9	502 	9CR	B	S	2
FT	#HET	84	 102 	ILE	B	5	503 	PLM	A	S	4
FT	#HET	84	 102 	ILE	B	9	502 	9CR	B	S	1
FT	#HET	87	 105 	ARG	B	5	503 	PLM	A	S	2
FT	#HET	88	 106 	ILE	B	5	503 	PLM	A	S	2
FT	#HET	88	 106 	ILE	B	9	502 	9CR	B	S	1
FT	#HET	94	 112 	ILE	B	7	500 	HEM	B	A	4
FT	#HET	95	 113 	ILE	B	7	500 	HEM	B	B	2
FT	#HET	95	 113 	ILE	B	8	501 	9CR	B	S	4
FT	#HET	102	 120 	TRP	B	7	500 	HEM	B	S	5
FT	#HET	106	 124 	ARG	B	7	500 	HEM	B	S	4
FT	#HET	113	 131 	LEU	B	7	500 	HEM	B	S	1
FT	#HET	114	 132 	ARG	B	6	504 	SO4	B	A	10
FT	#HET	115	 133 	ASN	B	6	504 	SO4	B	A	6
FT	#HET	183	 201 	PHE	B	9	502 	9CR	B	S	3
FT	#HET	186	 204 	ASN	B	9	502 	9CR	B	S	6
FT	#HET	187	 205 	PHE	B	9	502 	9CR	B	A	2
FT	#HET	190	 208 	LEU	B	9	502 	9CR	B	A	15
FT	#HET	191	 209 	ASN	B	9	502 	9CR	B	A	3
FT	#HET	194	 212 	TRP	B	5	503 	PLM	A	S	5
FT	#HET	199	 217 	ASN	B	9	502 	9CR	B	S	2
FT	#HET	208	 226 	PHE	B	5	503 	PLM	A	S	6
FT	#HET	208	 226 	PHE	B	10	503 	PLM	B	A	9
FT	#HET	209	 227 	PRO	B	10	503 	PLM	B	A	5
FT	#HET	210	 228 	GLY	B	10	503 	PLM	B	B	7
FT	#HET	211	 229 	THR	B	5	503 	PLM	A	S	3
FT	#HET	211	 229 	THR	B	10	503 	PLM	B	A	7
FT	#HET	212	 230 	HIS	B	5	503 	PLM	A	A	7
FT	#HET	215	 233 	VAL	B	5	503 	PLM	A	S	2
FT	#HET	216	 234 	LEU	B	5	503 	PLM	A	S	3
FT	#HET	223	 241 	ARG	B	9	502 	9CR	B	S	5
FT	#HET	276	 294 	LEU	B	7	500 	HEM	B	S	1
FT	#HET	278	 296 	VAL	B	8	501 	9CR	B	B	1
FT	#HET	278	 296 	VAL	B	9	502 	9CR	B	S	6
FT	#HET	279	 297 	ALA	B	7	500 	HEM	B	A	15
FT	#HET	280	 298 	GLY	B	7	500 	HEM	B	B	6
FT	#HET	283	 301 	THR	B	7	500 	HEM	B	A	7
FT	#HET	283	 301 	THR	B	8	501 	9CR	B	S	1
FT	#HET	284	 302 	THR	B	7	500 	HEM	B	A	5
FT	#HET	287	 305 	THR	B	7	500 	HEM	B	S	2
FT	#HET	338	 356 	GLN	B	7	500 	HEM	B	S	1
FT	#HET	343	 361 	LEU	B	7	500 	HEM	B	S	2
FT	#HET	348	 366 	VAL	B	7	500 	HEM	B	S	2
FT	#HET	348	 366 	VAL	B	8	501 	9CR	B	S	3
FT	#HET	349	 367 	PRO	B	8	501 	9CR	B	A	4
FT	#HET	350	 368 	HIS	B	7	500 	HEM	B	S	6
FT	#HET	409	 427 	PRO	B	7	500 	HEM	B	B	3
FT	#HET	410	 428 	PHE	B	7	500 	HEM	B	A	12
FT	#HET	411	 429 	SER	B	7	500 	HEM	B	S	6
FT	#HET	415	 433 	ARG	B	7	500 	HEM	B	A	18
FT	#HET	417	 435 	CYS	B	7	500 	HEM	B	A	23
FT	#HET	418	 436 	ALA	B	7	500 	HEM	B	A	5
FT	#HET	419	 437 	GLY	B	7	500 	HEM	B	B	6
FT	#HET	423	 441 	ALA	B	7	500 	HEM	B	S	2
FT	#HET	426	 444 	GLU	B	7	500 	HEM	B	S	1
FT	#HET	458	 476 	ILE	B	8	501 	9CR	B	S	1
FT	#HET	458	 476 	ILE	B	9	502 	9CR	B	S	3
FT	#HET	459	 477 	VAL	B	8	501 	9CR	B	S	2
FT	DISORDER	1	9
FT	DISORDER	473	476
CC	SEQUENCE	463 AA (ATOM);
CC	KLPPGPTPLP IIGNMLQIDV KDICKSFTNF SKVYGPVFTV YFGMNPIVVF HGYEAVKEAL
CC	IDNGEEFSGR GNSPISQRIT KGLGIISSNG KRWKEIRRFS LTTLRNFGMG KRSIEDRVQE
CC	EAHCLVEELR KTKASPCDPT FILGCAPCNV ICSVVFQKRF DYKDQNFLTL MKRFNENFRI
CC	LNSPWIQVCN NFPLLIDCFP GTHNKVLKNV ALTRSYIREK VKEHQASLDV NNPRDFIDCF
CC	LIKMEQEKDN QKSEFNIENL VGTVADLFVA GTETTSTTLR YGLLLLLKHP EVTAKVQEEI
CC	DHVIGRHRSP CMQDRSHMPY TDAVVHEIQR YSDLVPTGVP HAVTTDTKFR NYLIPKGTTI
CC	MALLTSVLHD DKEFPNPNIF DPGHFLDKNG NFKKSDYFMP FSAGKRICAG EGLARMELFL
CC	FLTTILQNFN LKSVDDLKNL NTTAVTKGIV SLPPSYQICF IPV
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MAKKTSSKGKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVY
CC	ATOM   ---------KLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVY
CC	                *****************************************
CC	SEQRES FGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGK
CC	ATOM   FGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGK
CC	       **************************************************
CC	SEQRES RWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTF
CC	ATOM   RWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTF
CC	       **************************************************
CC	SEQRES ILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNN
CC	ATOM   ILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNN
CC	       **************************************************
CC	SEQRES FPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFL
CC	ATOM   FPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFL
CC	       **************************************************
CC	SEQRES IKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPE
CC	ATOM   IKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPE
CC	       **************************************************
CC	SEQRES VTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPH
CC	ATOM   VTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPH
CC	       **************************************************
CC	SEQRES AVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGN
CC	ATOM   AVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGN
CC	       **************************************************
CC	SEQRES FKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLN
CC	ATOM   FKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLN
CC	       **************************************************
CC	SEQRES TTAVTKGIVSLPPSYQICFIPVHHHH
CC	ATOM   TTAVTKGIVSLPPSYQICFIPV----
CC	       **********************    
SQ	SEQUENCE	476 AA;      MW;         CN;
	MAKKTSSKGK LPPGPTPLPI IGNMLQIDVK DICKSFTNFS KVYGPVFTVY FGMNPIVVFH
	GYEAVKEALI DNGEEFSGRG NSPISQRITK GLGIISSNGK RWKEIRRFSL TTLRNFGMGK
	RSIEDRVQEE AHCLVEELRK TKASPCDPTF ILGCAPCNVI CSVVFQKRFD YKDQNFLTLM
	KRFNENFRIL NSPWIQVCNN FPLLIDCFPG THNKVLKNVA LTRSYIREKV KEHQASLDVN
	NPRDFIDCFL IKMEQEKDNQ KSEFNIENLV GTVADLFVAG TETTSTTLRY GLLLLLKHPE
	VTAKVQEEID HVIGRHRSPC MQDRSHMPYT DAVVHEIQRY SDLVPTGVPH AVTTDTKFRN
	YLIPKGTTIM ALLTSVLHDD KEFPNPNIFD PGHFLDKNGN FKKSDYFMPF SAGKRICAGE
	GLARMELFLF LTTILQNFNL KSVDDLKNLN TTAVTKGIVS LPPSYQICFI PVHHHH
//