ID 2HWHA STANDARD; PRT; 576 AA. DT CONVERTED FROM PDB (SEQRES) 2HWH DE RNA-directed RNA polymerase (NS5B) (p68) OS Hepatitis C virus CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.300 CC R-Factor 0.234 FT #SUB 7 1 HIS A 68 62 ASP B Protein S 1 FT #SUB 7 1 HIS A 72 66 ASP B Protein S 6 FT #SUB 63 57 LEU A 68 62 ASP B Protein A 4 FT #SUB 64 58 GLN A 66 60 LEU B Protein B 1 FT #SUB 64 58 GLN A 67 61 ASP B Protein B 2 FT #SUB 64 58 GLN A 68 62 ASP B Protein B 5 FT #SUB 64 58 GLN A 71 65 ARG B Protein A 6 FT #SUB 65 59 VAL A 66 60 LEU B Protein B 2 FT #SUB 66 60 LEU A 64 58 GLN B Protein B 1 FT #SUB 66 60 LEU A 65 59 VAL B Protein B 2 FT #SUB 66 60 LEU A 66 60 LEU B Protein B 7 FT #SUB 66 60 LEU A 71 65 ARG B Protein S 2 FT #SUB 67 61 ASP A 64 58 GLN B Protein B 2 FT #SUB 68 62 ASP A 63 57 LEU B Protein S 4 FT #SUB 68 62 ASP A 64 58 GLN B Protein A 5 FT #SUB 71 65 ARG A 64 58 GLN B Protein S 6 FT #SUB 71 65 ARG A 66 60 LEU B Protein S 2 FT #SUB 71 65 ARG A 237 231 ASN B Protein S 1 FT #SUB 72 66 ASP A 7 1 HIS B Protein S 4 FT #SUB 75 69 LYS A 236 230 GLU B Protein S 5 FT #SUB 236 230 GLU A 75 69 LYS B Protein S 5 FT #SUB 237 231 ASN A 71 65 ARG B Protein S 1 FT #SUB 240 234 ARG A 75 69 LYS B Protein S 1 FT #HET 425 419 LEU A 1 960 RNA A A 4 FT #HET 428 422 ARG A 1 960 RNA A S 2 FT #HET 429 423 MET A 1 960 RNA A B 1 FT #HET 480 474 LEU A 1 960 RNA A B 2 FT #HET 481 475 HIS A 1 960 RNA A B 1 FT #HET 482 476 SER A 1 960 RNA A B 8 FT #HET 483 477 TYR A 1 960 RNA A A 10 FT #HET 488 482 ILE A 1 960 RNA A S 4 FT #HET 503 497 LEU A 1 960 RNA A S 5 FT #HET 507 501 ARG A 1 960 RNA A S 3 FT #HET 534 528 TRP A 1 960 RNA A S 12 FT DISORDER 1 6 FT DISORDER 155 159 FT DISORDER 571 576 CC SEQUENCE 559 AA (ATOM); CC HHSYTWTGAL ITPCAAEESK LPINALSNSL LRHHNMVYAT TSRSAGLRQK KVTFDRLQVL CC DDHYRDVLKE MKAKASTVKA KLLSVEEACK LTPPHSAKSK FGYGAKDVRN LSSKAVNHIH CC SVWKDLLEDT VTPIDTTIMA KNEVFCVQRK PARLIVFPDL GVRVCEKMAL YDVVSTLPQV CC VMGSSYGFQY SPGQRVEFLV NTWKSKKNPM GFSYDTRCFD STVTENDIRV EESIYQCCDL CC APEARQAIKS LTERLYIGGP LTNSKGQNCG YRRCRASGVL TTSCGNTLTC YLKASAACRA CC AKLQDCTMLV NGDDLVVICE SAGVQEDAAS LRAFTEAMTR YSAPPGDPPQ PEYDLELITS CC CSSNVSVAHD ASGKRVYYLT RDPTTPLARA AWETARHTPV NSWLGNIIMY APTLWARMIL CC MTHFFSILLA QEQLEKALDC QIYGACYSIE PLDLPQIIER LHGLSAFSLH SYSPGEINRV CC ASCLRKLGVP PLRVWRHRAR SVRARLLSQG GRAATCGKYL FNWAVKTKLK LTPIPAASQL CC DLSGWFVAGY SGGDIYHSL CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES ASHHHHHHSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRS CC ATOM ------HHSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRS CC ******************************************** CC SEQRES AGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPP CC ATOM AGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPP CC ************************************************** CC SEQRES HSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEV CC ATOM HSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEV CC ************************************************** CC SEQRES FCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQ CC ATOM FCVQ-----RKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQ CC **** ***************************************** CC SEQRES YSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCD CC ATOM YSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCD CC ************************************************** CC SEQRES LAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLT CC ATOM LAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLT CC ************************************************** CC SEQRES CYLKASAACRAAKLQDCTMLVNGDDLVVICESAGVQEDAASLRAFTEAMT CC ATOM CYLKASAACRAAKLQDCTMLVNGDDLVVICESAGVQEDAASLRAFTEAMT CC ************************************************** CC SEQRES RYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLAR CC ATOM RYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLAR CC ************************************************** CC SEQRES AAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALD CC ATOM AAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALD CC ************************************************** CC SEQRES CQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGV CC ATOM CQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGV CC ************************************************** CC SEQRES PPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASQ CC ATOM PPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASQ CC ************************************************** CC SEQRES LDLSGWFVAGYSGGDIYHSLSRARPR CC ATOM LDLSGWFVAGYSGGDIYHSL------ CC ******************** SQ SEQUENCE 576 AA; MW; CN; ASHHHHHHSY TWTGALITPC AAEESKLPIN ALSNSLLRHH NMVYATTSRS AGLRQKKVTF DRLQVLDDHY RDVLKEMKAK ASTVKAKLLS VEEACKLTPP HSAKSKFGYG AKDVRNLSSK AVNHIHSVWK DLLEDTVTPI DTTIMAKNEV FCVQPEKGGR KPARLIVFPD LGVRVCEKMA LYDVVSTLPQ VVMGSSYGFQ YSPGQRVEFL VNTWKSKKNP MGFSYDTRCF DSTVTENDIR VEESIYQCCD LAPEARQAIK SLTERLYIGG PLTNSKGQNC GYRRCRASGV LTTSCGNTLT CYLKASAACR AAKLQDCTML VNGDDLVVIC ESAGVQEDAA SLRAFTEAMT RYSAPPGDPP QPEYDLELIT SCSSNVSVAH DASGKRVYYL TRDPTTPLAR AAWETARHTP VNSWLGNIIM YAPTLWARMI LMTHFFSILL AQEQLEKALD CQIYGACYSI EPLDLPQIIE RLHGLSAFSL HSYSPGEINR VASCLRKLGV PPLRVWRHRA RSVRARLLSQ GGRAATCGKY LFNWAVKTKL KLTPIPAASQ LDLSGWFVAG YSGGDIYHSL SRARPR // ID 2HWHB STANDARD; PRT; 576 AA. DT CONVERTED FROM PDB (SEQRES) 2HWH DE RNA-directed RNA polymerase (NS5B) (p68) OS Hepatitis C virus CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.300 CC R-Factor 0.234 FT #SUB 7 1 HIS B 72 66 ASP A Protein S 4 FT #SUB 63 57 LEU B 68 62 ASP A Protein A 4 FT #SUB 64 58 GLN B 66 60 LEU A Protein B 1 FT #SUB 64 58 GLN B 67 61 ASP A Protein B 2 FT #SUB 64 58 GLN B 68 62 ASP A Protein B 5 FT #SUB 64 58 GLN B 71 65 ARG A Protein A 6 FT #SUB 65 59 VAL B 66 60 LEU A Protein B 2 FT #SUB 66 60 LEU B 64 58 GLN A Protein B 1 FT #SUB 66 60 LEU B 65 59 VAL A Protein B 2 FT #SUB 66 60 LEU B 66 60 LEU A Protein A 7 FT #SUB 66 60 LEU B 71 65 ARG A Protein S 2 FT #SUB 67 61 ASP B 64 58 GLN A Protein B 2 FT #SUB 68 62 ASP B 7 1 HIS A Protein S 1 FT #SUB 68 62 ASP B 63 57 LEU A Protein S 4 FT #SUB 68 62 ASP B 64 58 GLN A Protein A 5 FT #SUB 71 65 ARG B 64 58 GLN A Protein S 6 FT #SUB 71 65 ARG B 66 60 LEU A Protein S 2 FT #SUB 71 65 ARG B 237 231 ASN A Protein S 1 FT #SUB 72 66 ASP B 7 1 HIS A Protein S 6 FT #SUB 75 69 LYS B 236 230 GLU A Protein S 5 FT #SUB 75 69 LYS B 240 234 ARG A Protein S 1 FT #SUB 236 230 GLU B 75 69 LYS A Protein S 5 FT #SUB 237 231 ASN B 71 65 ARG A Protein S 1 FT #HET 425 419 LEU B 2 960 RNA B A 4 FT #HET 428 422 ARG B 2 960 RNA B S 5 FT #HET 429 423 MET B 2 960 RNA B B 1 FT #HET 480 474 LEU B 2 960 RNA B B 2 FT #HET 482 476 SER B 2 960 RNA B B 8 FT #HET 483 477 TYR B 2 960 RNA B A 9 FT #HET 488 482 ILE B 2 960 RNA B S 3 FT #HET 503 497 LEU B 2 960 RNA B S 3 FT #HET 507 501 ARG B 2 960 RNA B S 3 FT #HET 534 528 TRP B 2 960 RNA B S 10 FT DISORDER 1 6 FT DISORDER 155 159 FT DISORDER 573 576 CC SEQUENCE 561 AA (ATOM); CC HHSYTWTGAL ITPCAAEESK LPINALSNSL LRHHNMVYAT TSRSAGLRQK KVTFDRLQVL CC DDHYRDVLKE MKAKASTVKA KLLSVEEACK LTPPHSAKSK FGYGAKDVRN LSSKAVNHIH CC SVWKDLLEDT VTPIDTTIMA KNEVFCVQRK PARLIVFPDL GVRVCEKMAL YDVVSTLPQV CC VMGSSYGFQY SPGQRVEFLV NTWKSKKNPM GFSYDTRCFD STVTENDIRV EESIYQCCDL CC APEARQAIKS LTERLYIGGP LTNSKGQNCG YRRCRASGVL TTSCGNTLTC YLKASAACRA CC AKLQDCTMLV NGDDLVVICE SAGVQEDAAS LRAFTEAMTR YSAPPGDPPQ PEYDLELITS CC CSSNVSVAHD ASGKRVYYLT RDPTTPLARA AWETARHTPV NSWLGNIIMY APTLWARMIL CC MTHFFSILLA QEQLEKALDC QIYGACYSIE PLDLPQIIER LHGLSAFSLH SYSPGEINRV CC ASCLRKLGVP PLRVWRHRAR SVRARLLSQG GRAATCGKYL FNWAVKTKLK LTPIPAASQL CC DLSGWFVAGY SGGDIYHSLS R CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES ASHHHHHHSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRS CC ATOM ------HHSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRS CC ******************************************** CC SEQRES AGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPP CC ATOM AGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPP CC ************************************************** CC SEQRES HSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEV CC ATOM HSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEV CC ************************************************** CC SEQRES FCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQ CC ATOM FCVQ-----RKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQ CC **** ***************************************** CC SEQRES YSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCD CC ATOM YSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCD CC ************************************************** CC SEQRES LAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLT CC ATOM LAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLT CC ************************************************** CC SEQRES CYLKASAACRAAKLQDCTMLVNGDDLVVICESAGVQEDAASLRAFTEAMT CC ATOM CYLKASAACRAAKLQDCTMLVNGDDLVVICESAGVQEDAASLRAFTEAMT CC ************************************************** CC SEQRES RYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLAR CC ATOM RYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLAR CC ************************************************** CC SEQRES AAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALD CC ATOM AAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALD CC ************************************************** CC SEQRES CQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGV CC ATOM CQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGV CC ************************************************** CC SEQRES PPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASQ CC ATOM PPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASQ CC ************************************************** CC SEQRES LDLSGWFVAGYSGGDIYHSLSRARPR CC ATOM LDLSGWFVAGYSGGDIYHSLSR---- CC ********************** SQ SEQUENCE 576 AA; MW; CN; ASHHHHHHSY TWTGALITPC AAEESKLPIN ALSNSLLRHH NMVYATTSRS AGLRQKKVTF DRLQVLDDHY RDVLKEMKAK ASTVKAKLLS VEEACKLTPP HSAKSKFGYG AKDVRNLSSK AVNHIHSVWK DLLEDTVTPI DTTIMAKNEV FCVQPEKGGR KPARLIVFPD LGVRVCEKMA LYDVVSTLPQ VVMGSSYGFQ YSPGQRVEFL VNTWKSKKNP MGFSYDTRCF DSTVTENDIR VEESIYQCCD LAPEARQAIK SLTERLYIGG PLTNSKGQNC GYRRCRASGV LTTSCGNTLT CYLKASAACR AAKLQDCTML VNGDDLVVIC ESAGVQEDAA SLRAFTEAMT RYSAPPGDPP QPEYDLELIT SCSSNVSVAH DASGKRVYYL TRDPTTPLAR AAWETARHTP VNSWLGNIIM YAPTLWARMI LMTHFFSILL AQEQLEKALD CQIYGACYSI EPLDLPQIIE RLHGLSAFSL HSYSPGEINR VASCLRKLGV PPLRVWRHRA RSVRARLLSQ GGRAATCGKY LFNWAVKTKL KLTPIPAASQ LDLSGWFVAG YSGGDIYHSL SRARPR //