ID	2H2QA	STANDARD;	PRT;	521	AA.
DT	CONVERTED FROM PDB (SEQRES) 2H2Q
DE	Bifunctional dihydrofolate reductase-thymidylate synthase
OS	Trypanosoma cruzi
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.400
CC	R-Factor	0.208
FT	#SUB	166	 166 	PRO	A	166	 166 	PRO	B	Protein	S	3
FT	#SUB	170	 170 	HIS	A	199	 199 	GLU	B	Protein	A	6
FT	#SUB	192	 192 	ARG	A	413	 413 	ASN	B	Protein	S	7
FT	#SUB	192	 192 	ARG	A	414	 414 	GLY	B	Protein	S	1
FT	#SUB	192	 192 	ARG	A	452	 452 	ARG	B	Protein	S	4
FT	#SUB	195	 195 	GLU	A	275	 275 	ARG	B	Protein	S	3
FT	#SUB	195	 195 	GLU	A	412	 412 	SER	B	Protein	S	1
FT	#SUB	195	 195 	GLU	A	413	 413 	ASN	B	Protein	S	4
FT	#SUB	195	 195 	GLU	A	415	 415 	GLU	B	Protein	S	3
FT	#SUB	198	 198 	THR	A	275	 275 	ARG	B	Protein	S	4
FT	#SUB	199	 199 	GLU	A	170	 170 	HIS	B	Protein	A	4
FT	#SUB	199	 199 	GLU	A	276	 276 	ASN	B	Protein	S	1
FT	#SUB	199	 199 	GLU	A	278	 278 	ARG	B	Protein	S	4
FT	#SUB	202	 202 	ALA	A	202	 202 	ALA	B	Protein	A	11
FT	#SUB	202	 202 	ALA	A	203	 203 	GLY	B	Protein	B	2
FT	#SUB	203	 203 	GLY	A	202	 202 	ALA	B	Protein	B	2
FT	#SUB	203	 203 	GLY	A	203	 203 	GLY	B	Protein	B	4
FT	#SUB	275	 275 	ARG	A	195	 195 	GLU	B	Protein	S	2
FT	#SUB	275	 275 	ARG	A	198	 198 	THR	B	Protein	S	1
FT	#SUB	412	 412 	SER	A	195	 195 	GLU	B	Protein	S	2
FT	#SUB	413	 413 	ASN	A	192	 192 	ARG	B	Protein	A	11
FT	#SUB	413	 413 	ASN	A	195	 195 	GLU	B	Protein	S	4
FT	#SUB	415	 415 	GLU	A	195	 195 	GLU	B	Protein	S	1
FT	#HET	27	  27 	VAL	A	1	523 	NAP	A	A	3
FT	#HET	28	  28 	ALA	A	1	523 	NAP	A	A	8
FT	#HET	35	  35 	ILE	A	1	523 	NAP	A	A	7
FT	#HET	36	  36 	GLY	A	1	523 	NAP	A	B	1
FT	#HET	37	  37 	ASP	A	1	523 	NAP	A	B	1
FT	#HET	38	  38 	GLY	A	1	523 	NAP	A	B	4
FT	#HET	39	  39 	ARG	A	1	523 	NAP	A	B	8
FT	#HET	40	  40 	SER	A	1	523 	NAP	A	B	9
FT	#HET	41	  41 	ILE	A	1	523 	NAP	A	A	6
FT	#HET	77	  77 	GLY	A	1	523 	NAP	A	B	4
FT	#HET	78	  78 	ARG	A	1	523 	NAP	A	A	12
FT	#HET	79	  79 	LYS	A	1	523 	NAP	A	A	11
FT	#HET	80	  80 	THR	A	1	523 	NAP	A	A	8
FT	#HET	99	  99 	LEU	A	1	523 	NAP	A	B	4
FT	#HET	100	 100 	SER	A	1	523 	NAP	A	A	6
FT	#HET	101	 101 	SER	A	1	523 	NAP	A	A	7
FT	#HET	102	 102 	THR	A	1	523 	NAP	A	A	7
FT	#HET	130	 130 	GLY	A	1	523 	NAP	A	B	14
FT	#HET	131	 131 	GLY	A	1	523 	NAP	A	B	6
FT	#HET	154	 154 	ILE	A	1	523 	NAP	A	B	2
FT	#HET	155	 155 	GLY	A	1	523 	NAP	A	B	3
FT	#HET	156	 156 	GLY	A	1	523 	NAP	A	B	10
FT	#HET	157	 157 	GLY	A	1	523 	NAP	A	B	6
FT	#HET	158	 158 	SER	A	1	523 	NAP	A	A	11
FT	#HET	159	 159 	VAL	A	1	523 	NAP	A	A	2
FT	#HET	160	 160 	TYR	A	1	523 	NAP	A	S	2
FT	#HET	403	 403 	CYS	A	2	611 	DU	A	S	9
FT	#HET	404	 404 	HIS	A	2	611 	DU	A	S	2
FT	#HET	422	 422 	GLN	A	2	611 	DU	A	S	4
FT	#HET	423	 423 	ARG	A	2	611 	DU	A	S	8
FT	#HET	424	 424 	SER	A	2	611 	DU	A	A	10
FT	#HET	425	 425 	CYS	A	2	611 	DU	A	B	1
FT	#HET	426	 426 	ASP	A	2	611 	DU	A	A	6
FT	#HET	430	 430 	GLY	A	2	611 	DU	A	B	2
FT	#HET	434	 434 	ASN	A	2	611 	DU	A	S	9
FT	#HET	464	 464 	HIS	A	2	611 	DU	A	S	7
FT	#HET	466	 466 	TYR	A	2	611 	DU	A	S	3
FT	DISORDER	1	1
FT	DISORDER	516	521
CC	SEQUENCE	514 AA (ATOM);
CC	SLFKIRMPET VAEGTRLALR AFSLVVAVDE RGGIGDGRSI PWNVPEDMKF FRDVTTKLRG
CC	KNVKPSPAKR NAVVMGRKTW DSIPPKFRPL PGRLNVVLSS TLTTQHLLDG LPDEEKRNLH
CC	ADSIVAVNGG LEQALQLLAS PNYTPSIETV YCIGGGSVYA EALRPPCVHL LQAIYRTTIR
CC	ASESSCSVFF RVPESGTEAA AGIEWQRETI SEELTSANGN ETKYYFEKLI PRNREEEQYL
CC	SLVDRIIREG NVKHDRTGVG TLSIFGAQMR FSLRNNRLPL LTTKRVFWRG VCEELLWFLR
CC	GETYAKKLSD KGVHIWDDNG SRAFLDSRGL TEYEEMDLGP VYGFQWRHFG AAYTHHDANY
CC	DGQGVDQIKA IVETLKTNPD DRRMLFTAWN PSALPRMALP PCHLLAQFYV SNGELSCMLY
CC	QRSCDMGLGV PFNIASYALL TILIAKATGL RPGELVHTLG DAHVYSNHVE PCNEQLKRVP
CC	RAFPYLVFRR EREFLEDYEE GDMEVIDYAP YPPI
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MSLFKIRMPETVAEGTRLALRAFSLVVAVDERGGIGDGRSIPWNVPEDMK
CC	ATOM   -SLFKIRMPETVAEGTRLALRAFSLVVAVDERGGIGDGRSIPWNVPEDMK
CC	        *************************************************
CC	SEQRES FFRDVTTKLRGKNVKPSPAKRNAVVMGRKTWDSIPPKFRPLPGRLNVVLS
CC	ATOM   FFRDVTTKLRGKNVKPSPAKRNAVVMGRKTWDSIPPKFRPLPGRLNVVLS
CC	       **************************************************
CC	SEQRES STLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLASPNYTPSIET
CC	ATOM   STLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLASPNYTPSIET
CC	       **************************************************
CC	SEQRES VYCIGGGSVYAEALRPPCVHLLQAIYRTTIRASESSCSVFFRVPESGTEA
CC	ATOM   VYCIGGGSVYAEALRPPCVHLLQAIYRTTIRASESSCSVFFRVPESGTEA
CC	       **************************************************
CC	SEQRES AAGIEWQRETISEELTSANGNETKYYFEKLIPRNREEEQYLSLVDRIIRE
CC	ATOM   AAGIEWQRETISEELTSANGNETKYYFEKLIPRNREEEQYLSLVDRIIRE
CC	       **************************************************
CC	SEQRES GNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELLWFL
CC	ATOM   GNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELLWFL
CC	       **************************************************
CC	SEQRES RGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHF
CC	ATOM   RGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHF
CC	       **************************************************
CC	SEQRES GAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMAL
CC	ATOM   GAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMAL
CC	       **************************************************
CC	SEQRES PPCHLLAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATG
CC	ATOM   PPCHLLAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATG
CC	       **************************************************
CC	SEQRES LRPGELVHTLGDAHVYSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDYE
CC	ATOM   LRPGELVHTLGDAHVYSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDYE
CC	       **************************************************
CC	SEQRES EGDMEVIDYAPYPPISMKMAV
CC	ATOM   EGDMEVIDYAPYPPI------
CC	       ***************      
SQ	SEQUENCE	521 AA;      MW;         CN;
	MSLFKIRMPE TVAEGTRLAL RAFSLVVAVD ERGGIGDGRS IPWNVPEDMK FFRDVTTKLR
	GKNVKPSPAK RNAVVMGRKT WDSIPPKFRP LPGRLNVVLS STLTTQHLLD GLPDEEKRNL
	HADSIVAVNG GLEQALQLLA SPNYTPSIET VYCIGGGSVY AEALRPPCVH LLQAIYRTTI
	RASESSCSVF FRVPESGTEA AAGIEWQRET ISEELTSANG NETKYYFEKL IPRNREEEQY
	LSLVDRIIRE GNVKHDRTGV GTLSIFGAQM RFSLRNNRLP LLTTKRVFWR GVCEELLWFL
	RGETYAKKLS DKGVHIWDDN GSRAFLDSRG LTEYEEMDLG PVYGFQWRHF GAAYTHHDAN
	YDGQGVDQIK AIVETLKTNP DDRRMLFTAW NPSALPRMAL PPCHLLAQFY VSNGELSCML
	YQRSCDMGLG VPFNIASYAL LTILIAKATG LRPGELVHTL GDAHVYSNHV EPCNEQLKRV
	PRAFPYLVFR REREFLEDYE EGDMEVIDYA PYPPISMKMA V
//
ID	2H2QB	STANDARD;	PRT;	521	AA.
DT	CONVERTED FROM PDB (SEQRES) 2H2Q
DE	Bifunctional dihydrofolate reductase-thymidylate synthase
OS	Trypanosoma cruzi
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.400
CC	R-Factor	0.208
FT	#SUB	166	 166 	PRO	B	166	 166 	PRO	A	Protein	S	3
FT	#SUB	170	 170 	HIS	B	199	 199 	GLU	A	Protein	A	4
FT	#SUB	192	 192 	ARG	B	413	 413 	ASN	A	Protein	S	11
FT	#SUB	195	 195 	GLU	B	275	 275 	ARG	A	Protein	S	2
FT	#SUB	195	 195 	GLU	B	412	 412 	SER	A	Protein	S	2
FT	#SUB	195	 195 	GLU	B	413	 413 	ASN	A	Protein	S	4
FT	#SUB	195	 195 	GLU	B	415	 415 	GLU	A	Protein	S	1
FT	#SUB	198	 198 	THR	B	275	 275 	ARG	A	Protein	S	1
FT	#SUB	199	 199 	GLU	B	170	 170 	HIS	A	Protein	A	6
FT	#SUB	202	 202 	ALA	B	202	 202 	ALA	A	Protein	A	11
FT	#SUB	202	 202 	ALA	B	203	 203 	GLY	A	Protein	B	2
FT	#SUB	203	 203 	GLY	B	202	 202 	ALA	A	Protein	B	2
FT	#SUB	203	 203 	GLY	B	203	 203 	GLY	A	Protein	B	4
FT	#SUB	275	 275 	ARG	B	195	 195 	GLU	A	Protein	S	3
FT	#SUB	275	 275 	ARG	B	198	 198 	THR	A	Protein	S	4
FT	#SUB	276	 276 	ASN	B	199	 199 	GLU	A	Protein	S	1
FT	#SUB	278	 278 	ARG	B	199	 199 	GLU	A	Protein	S	4
FT	#SUB	412	 412 	SER	B	195	 195 	GLU	A	Protein	S	1
FT	#SUB	413	 413 	ASN	B	192	 192 	ARG	A	Protein	B	7
FT	#SUB	413	 413 	ASN	B	195	 195 	GLU	A	Protein	S	4
FT	#SUB	414	 414 	GLY	B	192	 192 	ARG	A	Protein	B	1
FT	#SUB	415	 415 	GLU	B	195	 195 	GLU	A	Protein	S	3
FT	#SUB	452	 452 	ARG	B	192	 192 	ARG	A	Protein	S	4
FT	#HET	27	  27 	VAL	B	3	524 	NAP	B	A	3
FT	#HET	28	  28 	ALA	B	3	524 	NAP	B	A	8
FT	#HET	35	  35 	ILE	B	3	524 	NAP	B	S	1
FT	#HET	77	  77 	GLY	B	3	524 	NAP	B	B	8
FT	#HET	78	  78 	ARG	B	3	524 	NAP	B	A	18
FT	#HET	79	  79 	LYS	B	3	524 	NAP	B	A	12
FT	#HET	80	  80 	THR	B	3	524 	NAP	B	A	9
FT	#HET	83	  83 	SER	B	3	524 	NAP	B	S	6
FT	#HET	99	  99 	LEU	B	3	524 	NAP	B	B	4
FT	#HET	100	 100 	SER	B	3	524 	NAP	B	A	10
FT	#HET	101	 101 	SER	B	3	524 	NAP	B	A	10
FT	#HET	102	 102 	THR	B	3	524 	NAP	B	A	6
FT	#HET	130	 130 	GLY	B	3	524 	NAP	B	B	14
FT	#HET	131	 131 	GLY	B	3	524 	NAP	B	B	5
FT	#HET	154	 154 	ILE	B	3	524 	NAP	B	B	2
FT	#HET	155	 155 	GLY	B	3	524 	NAP	B	B	3
FT	#HET	156	 156 	GLY	B	3	524 	NAP	B	B	12
FT	#HET	157	 157 	GLY	B	3	524 	NAP	B	B	5
FT	#HET	158	 158 	SER	B	3	524 	NAP	B	A	5
FT	#HET	160	 160 	TYR	B	3	524 	NAP	B	S	2
FT	#HET	403	 403 	CYS	B	4	612 	DU	B	S	8
FT	#HET	404	 404 	HIS	B	4	612 	DU	B	S	2
FT	#HET	422	 422 	GLN	B	4	612 	DU	B	S	4
FT	#HET	423	 423 	ARG	B	4	612 	DU	B	S	7
FT	#HET	424	 424 	SER	B	4	612 	DU	B	A	9
FT	#HET	425	 425 	CYS	B	4	612 	DU	B	B	2
FT	#HET	426	 426 	ASP	B	4	612 	DU	B	A	8
FT	#HET	430	 430 	GLY	B	4	612 	DU	B	B	4
FT	#HET	434	 434 	ASN	B	4	612 	DU	B	S	9
FT	#HET	464	 464 	HIS	B	4	612 	DU	B	S	7
FT	#HET	466	 466 	TYR	B	4	612 	DU	B	S	4
FT	DISORDER	36	42
FT	DISORDER	61	65
FT	DISORDER	113	116
FT	DISORDER	182	188
FT	DISORDER	516	521
CC	SEQUENCE	492 AA (ATOM);
CC	MSLFKIRMPE TVAEGTRLAL RAFSLVVAVD ERGGIWNVPE DMKFFRDVTT KLRPSPAKRN
CC	AVVMGRKTWD SIPPKFRPLP GRLNVVLSST LTTQHLLDGL KRNLHADSIV AVNGGLEQAL
CC	QLLASPNYTP SIETVYCIGG GSVYAEALRP PCVHLLQAIY RTTIRVFFRV PESGTEAAAG
CC	IEWQRETISE ELTSANGNET KYYFEKLIPR NREEEQYLSL VDRIIREGNV KHDRTGVGTL
CC	SIFGAQMRFS LRNNRLPLLT TKRVFWRGVC EELLWFLRGE TYAKKLSDKG VHIWDDNGSR
CC	AFLDSRGLTE YEEMDLGPVY GFQWRHFGAA YTHHDANYDG QGVDQIKAIV ETLKTNPDDR
CC	RMLFTAWNPS ALPRMALPPC HLLAQFYVSN GELSCMLYQR SCDMGLGVPF NIASYALLTI
CC	LIAKATGLRP GELVHTLGDA HVYSNHVEPC NEQLKRVPRA FPYLVFRRER EFLEDYEEGD
CC	MEVIDYAPYP PI
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MSLFKIRMPETVAEGTRLALRAFSLVVAVDERGGIGDGRSIPWNVPEDMK
CC	ATOM   MSLFKIRMPETVAEGTRLALRAFSLVVAVDERGGI-------WNVPEDMK
CC	       ***********************************       ********
CC	SEQRES FFRDVTTKLRGKNVKPSPAKRNAVVMGRKTWDSIPPKFRPLPGRLNVVLS
CC	ATOM   FFRDVTTKLR-----PSPAKRNAVVMGRKTWDSIPPKFRPLPGRLNVVLS
CC	       **********     ***********************************
CC	SEQRES STLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALQLLASPNYTPSIET
CC	ATOM   STLTTQHLLDGL----KRNLHADSIVAVNGGLEQALQLLASPNYTPSIET
CC	       ************    **********************************
CC	SEQRES VYCIGGGSVYAEALRPPCVHLLQAIYRTTIRASESSCSVFFRVPESGTEA
CC	ATOM   VYCIGGGSVYAEALRPPCVHLLQAIYRTTIR-------VFFRVPESGTEA
CC	       *******************************       ************
CC	SEQRES AAGIEWQRETISEELTSANGNETKYYFEKLIPRNREEEQYLSLVDRIIRE
CC	ATOM   AAGIEWQRETISEELTSANGNETKYYFEKLIPRNREEEQYLSLVDRIIRE
CC	       **************************************************
CC	SEQRES GNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELLWFL
CC	ATOM   GNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELLWFL
CC	       **************************************************
CC	SEQRES RGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHF
CC	ATOM   RGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHF
CC	       **************************************************
CC	SEQRES GAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMAL
CC	ATOM   GAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMAL
CC	       **************************************************
CC	SEQRES PPCHLLAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATG
CC	ATOM   PPCHLLAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATG
CC	       **************************************************
CC	SEQRES LRPGELVHTLGDAHVYSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDYE
CC	ATOM   LRPGELVHTLGDAHVYSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDYE
CC	       **************************************************
CC	SEQRES EGDMEVIDYAPYPPISMKMAV
CC	ATOM   EGDMEVIDYAPYPPI------
CC	       ***************      
SQ	SEQUENCE	521 AA;      MW;         CN;
	MSLFKIRMPE TVAEGTRLAL RAFSLVVAVD ERGGIGDGRS IPWNVPEDMK FFRDVTTKLR
	GKNVKPSPAK RNAVVMGRKT WDSIPPKFRP LPGRLNVVLS STLTTQHLLD GLPDEEKRNL
	HADSIVAVNG GLEQALQLLA SPNYTPSIET VYCIGGGSVY AEALRPPCVH LLQAIYRTTI
	RASESSCSVF FRVPESGTEA AAGIEWQRET ISEELTSANG NETKYYFEKL IPRNREEEQY
	LSLVDRIIRE GNVKHDRTGV GTLSIFGAQM RFSLRNNRLP LLTTKRVFWR GVCEELLWFL
	RGETYAKKLS DKGVHIWDDN GSRAFLDSRG LTEYEEMDLG PVYGFQWRHF GAAYTHHDAN
	YDGQGVDQIK AIVETLKTNP DDRRMLFTAW NPSALPRMAL PPCHLLAQFY VSNGELSCML
	YQRSCDMGLG VPFNIASYAL LTILIAKATG LRPGELVHTL GDAHVYSNHV EPCNEQLKRV
	PRAFPYLVFR REREFLEDYE EGDMEVIDYA PYPPISMKMA V
//